Molecular changes linked to inflammation and how brain cells process proteins and genetic material may occur before the onset of amyotrophic lateral sclerosis (ALS) symptoms, a study in a mouse model of SOD1-related ALS suggests. The findings also point to changes in the hypothalamus, a brain region involved in…
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Researchers identified changes in 10 genes that may help diagnose or track amyotrophic lateral sclerosis (ALS), according to a computer analysis of thousands of genes. The study compared whole-blood samples from ALS patients and healthy individuals, uncovering nearly 1,000 genes with altered gene activity, along with related molecular pathways…
Acelot has dosed the first healthy volunteer in a Phase 1a clinical trial testing ACE-2223, its investigational oral treatment candidate designed to target aggregated TDP-43 in people with amyotrophic lateral sclerosis (ALS). In the vast majority of people with ALS, the TDP-43 protein moves to the wrong place in…
Geneuro has received a European patent for GNK-301, its experimental therapy designed to target a viral protein thought to contribute to amyotrophic lateral sclerosis (ALS), and plans to begin Phase 1 clinical trials in the second half of 2027. The antibody-based therapy was developed through a partnership between…
Paradromics’ investigational Connexus brain-computer interface (BCI) enabled a woman with a progressive motor neuron disease to generate her own words in real time, answer open-ended questions, and communicate with her family using synthesized speech. The woman, who had a severe impairment of her ability to speak, was the first…
Mindy Henderson has spent much of her life challenging the limits others have placed on her. When she was diagnosed with spinal muscular atrophy (SMA) — a genetic condition that causes muscles to weaken over time — as an infant, doctors told her parents that she might not live long…
Coya Therapeutics is approaching full enrollment in its main clinical trial for COYA 302, an experimental therapy for amyotrophic lateral sclerosis (ALS), having signed on its 100th participant. The Phase 2/3 ALSTARS trial (NCT07161999) aims to recruit 120 adults with ALS across sites in the U.S.
Five Canadian students personally affected by amyotrophic lateral sclerosis (ALS) will each receive $2,500 to support their studies in the 2026-2027 academic year. The ALS Canada Kevin Daly Bursary award winners were chosen for their contributions to the ALS community through caregiving, advocacy, fundraising, volunteering, or awareness efforts. The bursary…
Filmmaker and University of Virginia graduate Chris Farina had the idea for a documentary about death and dying about 10 years ago. Now he’s in the final stages of amyotrophic lateral sclerosis (ALS), and is relying on friends to help him complete the project. One of those friends is…
Among people living with amyotrophic lateral sclerosis (ALS), requests to be referred for medical assistance in dying, known as MAiD, may have more to do with individual preferences about life-sustaining interventions than disease severity. That’s according to a new Canadian study showing that people with ALS using noninvasive…
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