Compare substances

With an editorial comparison

• Modafinil vs Caffeine

  Eugeroic and adenosine-receptor stimulant: mechanism, half-life, legal status.

• Modafinil vs Armodafinil

  Modafinil and its R-enantiomer: half-life and the records for each.

• Modafinil vs Adrafinil

  A drug and its prodrug: conversion, recorded liver effects, legal status.

• Modafinil vs Methylphenidate

  Eugeroic and Schedule II stimulant: mechanism, graded evidence, legal status.

• Methylphenidate vs Amphetamine (Adderall)

  Two prescription ADHD stimulants: reuptake inhibition and release.

• L-Theanine vs Caffeine

  The pairing studied in combination trials, and each substance alone.

• Alpha-GPC vs CDP-Choline

  Two choline sources: structure, graded benefits, side effects.

• Alpha-GPC vs Acetyl-L-Carnitine (ALCAR)

  A choline donor and an acetyl-group donor: mechanism and evidence.

• Piracetam vs Aniracetam

  The first racetam and a fat-soluble one: graded benefits and history.

• Piracetam vs Noopept

  A racetam and a dipeptide: dose ranges and the evidence on file.

• Piracetam vs Phenylpiracetam

  Two racetams: graded benefits and recorded tolerance.

• Aniracetam vs Noopept

  Two compounds studied for anxiety and memory: mechanism and half-life.

• Bacopa Monnieri vs Huperzine A

  An Ayurvedic herb and an acetylcholinesterase inhibitor studied for memory.

• Bacopa Monnieri vs Lion's Mane

  An Ayurvedic herb and a medicinal mushroom: mechanism and evidence.

• Lion's Mane vs Noopept

  A mushroom and a dipeptide, both linked to nerve growth factors.

• Creatine vs Taurine

  Two amino-acid-derived supplements: mechanism and graded benefits.

• Ashwagandha vs Rhodiola Rosea

  Two adaptogens: cortisol, fatigue and the evidence behind each.

• Ashwagandha vs Kava

  An adaptogen and a GABAergic herb studied for anxiety: records and risks.

• Ashwagandha vs Tongkat Ali

  Two herbs studied for cortisol and testosterone.

• Rhodiola Rosea vs Panax Ginseng (Korean)

  Two adaptogens studied for fatigue: mechanism and evidence.

• L-Tyrosine vs L-Tryptophan

  Precursors of catecholamines and of serotonin.

• 5-HTP vs L-Tryptophan

  Two serotonin precursors, one and two steps from serotonin.

• Magnesium L-Threonate vs Magnesium Glycinate

  Two magnesium salts: brain magnesium and the graded evidence.

• Magnesium L-Threonate vs Apigenin

  A magnesium salt and a chamomile flavonoid studied for sleep.

• Nicotinamide Riboside (NR) vs NMN

  Two NAD+ precursors and the human trials on file.

• Resveratrol vs Pterostilbene

  Two related polyphenols: structure and the evidence for each.

• Metformin vs Rapamycin

  Two prescription drugs studied for ageing: mechanism and evidence.

• Fisetin vs Quercetin

  Two flavonoids studied as senolytics.

• CoQ10 vs PQQ

  Two mitochondrial cofactors: mechanism and graded benefits.

• Saffron vs 5-HTP

  Two substances studied for mood: evidence base and recorded risks.

• Qualia Mind vs Mind Lab Pro

  Two multi-ingredient blends: ingredients and evidence grades.

• Qualia Mind vs Alpha Brain

  Two multi-ingredient blends: ingredients and evidence grades.