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333 <div id="content" class="site-content"> 334 335 <section id="primary" class="content-area"> 336 <main id="main" class="site-main"> 337 338 339<article id="post-771" class="post-771 page type-page status-publish hentry entry"> 340 341 <header class="entry-header responsive-max-width"> 342 343<h1 class="entry-title">About us</h1> 344 </header> 345 346 347 <div class="entry-content"> 348 <nav class="is-responsive items-justified-center wp-block-navigation is-content-justification-center is-layout-flex wp-container-core-navigation-is-layout-3e41869c wp-block-navigation-is-layout-flex" aria-label="Navigation" 349 data-wp-interactive="core/navigation" data-wp-context='{"overlayOpenedBy":{"click":false,"hover":false,"focus":false},"type":"overlay","roleAttribute":"","ariaLabel":"Menu"}'><button aria-haspopup="dialog" aria-label="Open menu" class="wp-block-navigation__responsive-container-open" 350 data-wp-on--click="actions.openMenuOnClick" 351 data-wp-on--keydown="actions.handleMenuKeydown" 352 ><svg width="24" height="24" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" aria-hidden="true" focusable="false"><path d="M4 7.5h16v1.5H4z"></path><path d="M4 15h16v1.5H4z"></path></svg></button> 353 <div class="wp-block-navigation__responsive-container" id="modal-1" 354 data-wp-class--has-modal-open="state.isMenuOpen" 355 data-wp-class--is-menu-open="state.isMenuOpen" 356 data-wp-watch="callbacks.initMenu" 357 data-wp-on--keydown="actions.handleMenuKeydown" 358 data-wp-on--focusout="actions.handleMenuFocusout" 359 tabindex="-1" 360 > 361 <div class="wp-block-navigation__responsive-close" tabindex="-1"> 362 <div class="wp-block-navigation__responsive-dialog" 363 data-wp-bind--aria-modal="state.ariaModal" 364 data-wp-bind--aria-label="state.ariaLabel" 365 data-wp-bind--role="state.roleAttribute" 366 > 367 <button aria-label="Close menu" class="wp-block-navigation__responsive-container-close" 368 data-wp-on--click="actions.closeMenuOnClick" 369 ><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="24" height="24" aria-hidden="true" focusable="false"><path d="m13.06 12 6.47-6.47-1.06-1.06L12 10.94 5.53 4.47 4.47 5.53 10.94 12l-6.47 6.47 1.06 1.06L12 13.06l6.47 6.47 1.06-1.06L13.06 12Z"></path></svg></button> 370 <div class="wp-block-navigation__responsive-container-content" 371 data-wp-watch="callbacks.focusFirstElement" 372 id="modal-1-content"> 373 <ul class="wp-block-navigation__container is-responsive items-justified-center wp-block-navigation"><ul class="wp-block-page-list"><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/about-the-pi/">About the PI</a></li><li class="wp-block-pages-list__item current-menu-item wp-block-navigation-item open-on-hover-click menu-item-home"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/" aria-current="page">About us</a></li><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/our-research/">Our Research</a></li><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/publications/">Publications</a></li><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/recent-news/">Recent News</a></li><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/team/">Team</a></li><li class="wp-block-pages-list__item wp-block-navigation-item open-on-hover-click"><a class="wp-block-pages-list__item__link wp-block-navigation-item__content" href="https://brunklab.org/contact/">Contact</a></li></ul></ul> 374 375 </div> 376 </div> 377 </div>
378 </div></nav> 379 380 381<div style="height:100px" aria-hidden="true" class="wp-block-spacer"></div> 382 383 384 385<h2 class="wp-block-heading">Decoding Genetic Variation</h2> 386 387 388 389<p class="wp-block-paragraph">The Brunk Lab is a hybrid experimental and computational research group that studies how genetic variation shapes cellular systems. Our work sits at the intersection of cytogenetics, genome sciences and evolutionary biology and imaging where we integrate multiomic data, quantitative imaging, and computational modeling to understand how molecular and structural variation influence genome organization and cellular behavior. By combining experimental measurements with (big) data driven approaches, we aim to uncover how variants and chromosomal alterations propagate through regulatory networks to influence phenotype and cellular adaptation.</p> 390 391 392 393<p class="wp-block-paragraph">Our research spans multiple scales of biology. We investigate how protein variants alter molecular function, how structural changes in the genome reshape gene regulation, and how large scale genomic features such as extrachromosomal DNA contribute to cellular heterogeneity and evolutionary dynamics. Through this integrated approach, we seek to build a more complete understanding of how genetic variation drives biological function in health and disease. </p> 394 395 396 397<p class="wp-block-paragraph">The Brunk lab is located at the University of North Carolina at Chapel Hill, in the heart of a vibrant scientific community that brings together researchers from chemistry, biology, genetics, computational biology, pharmacology, and medicine. Our team reflects this interdisciplinary spirit, with trainees and collaborators spanning diverse scientific backgrounds including chemistry, biology, genetics, computer science, engineering, and systems pharmacology. This range of expertise allows us to approach complex biological questions from multiple perspectives and develop new tools for understanding genome function.</p> 398 399 400 401<p class="wp-block-paragraph">We are located walking distance from the UNC Medical Center and the Lineberger Comprehensive Cancer Center and a short drive from the Research Triangle Park, providing close connections to industry, clinicians and translational researchers. This environment fosters collaborations that allow our fundamental discoveries about genome structure and variation to inform new approaches to understanding disease and advancing single cell technologies.</p> 402 403 404 405<p class="wp-block-paragraph">Beyond research, we are deeply committed to training the next generation of scientists. Our lab emphasizes interdisciplinary learning, quantitative thinking, and open science, creating an environment where students and researchers can develop both experimental and computational expertise while tackling challenging problems in modern biology.</p> 406 407 408 409<div data-carousel-extra='{"blog_id":60109915,"permalink":"https://brunklab.org/"}' class="wp-block-jetpack-tiled-gallery aligncenter is-style-rectangular"><div class=""><div class="tiled-gallery__gallery"><div class="tiled-gallery__row"><div class="tiled-gallery__col" style="flex-basis:62.61559%"><figure class="tiled-gallery__item"><img data-attachment-id="1397" data-permalink="https://brunklab.org/fall_color_11_11_002m_0b66e623-9a64-49ab-b135-f17716769022/" data-orig-file="https://brunklab.org/wp-content/uploads/2021/03/fall_color_11_11_002m_0b66e623-9a64-49ab-b135-f17716769022.jpeg" data-orig-size="1200,818" data-comments-opened="0" data-image-title="fall_color_11_11_002m_0b66e623-9a64-49ab-b135-f17716769022" 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