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47<!-- End Google Tag Manager (noscript) --><div data-controller="InterstitialComponent" class="interstitial"><div popup><div close></div><div class="external"><h3>You are now leaving<br>www.veletri.com</h3><p>By clicking “CONTINUE” below, you will be taken to a website that may contain links or references to other websites to which our <a href="https://www.janssen.com/us/privacy-policy" target="_blank" style="color:#EC008C;" privacy-policy>Privacy Policy</a> may not apply. We encourage you to read the Privacy Policy of every website you visit.</p><p>You are solely responsible for your interactions with such websites.</p></div><div class="hcp"><p>The information contained in this section of the site is intended for US healthcare professionals only.</p><small>Click the appropriate link below.</small></div><div buttons><a style="" href="" target="_blank" continue>Continue<img src="/assets/images/patient/access_and_support/arrow.png" alt="arrow" width="39" height="39" loading="lazy"></a><a cancel>Cancel<img src="/assets/images/patient/access_and_support/close-dark.png" alt="cancel" width="39" height="39" loading="lazy"></a></div></div></div><div class="patient"><section data-controller="HeaderComponent" data-sticky="false" class="header"><header><div class="container"><a href="/index.html" class="header__logo"><img src="/assets/images/logoVeletri.png" alt="Brand Logo" width="671" height="254" loading="lazy"></a><div class="header__dsk_nav"><ul class="top-nav"><li><a href="https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/VELETRI-pi.pdf" target="_blank">Full Prescribing Information</a></li><li><a href="https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/VELETRI-pi-es.pdf" target="_blank">Información en Español</a></li><li><a href="/#ISI">Important Safety Information</a></li><li><a open-interstitial="https://www.janssen.com/us/legal-notice" href="">Legal Notice</a></li><li>

47<a open-interstitial="https://www.janssencarepath.com/patient/veletri/patient-support" href="">J&J withMe</a></li><li><a href="/contact-us.html">Contact Us</a></li><li><a open-interstitial-hcp="hcp/" href="">Healthcare Professionals</a></li></ul><nav><ul><li class="navMenu navMenu" data-navmenu="0"><a href="/patient-understanding-pah.html"><p>Understanding PAH</p></a><div class="navSubMenu" data-navsubmenu="0"></div></li><li class="navMenu navMenu" data-navmenu="1"><a href="/patient-what-is-veletri.html"><p>What is VELETRI<sup>&reg;</sup>?</p><img src="assets/images/arrow.svg" alt="arrow" class="only-mobile" loading="lazy"></a><div class="navSubMenu subTabs" data-navsubmenu="1"><a href="/patient-what-is-veletri.html#howWorks" class="subMenuLink">How VELETRI<sup>&reg;</sup> works </a><a href="/patient-what-is-veletri.html#sideEffects" class="subMenuLink">Side effects of VELETRI<sup>&reg;</sup></a></div></li><li class="navMenu navMenu" data-navmenu="2"><a href="/patient-taking-veletri.html"><p>Taking VELETRI<sup>&reg;</sup></p><img src="assets/images/arrow.svg" alt="arrow" class="only-mobile" loading="lazy"></a><div class="navSubMenu subTabs" data-navsubmenu="2"><a href="/patient-taking-veletri.html#startingVeletri" class="subMenuLink">Starting VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#preparingStoring" class="subMenuLink">Storing VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#usingVeletri" class="subMenuLink">Using VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#helpFul" class="subMenuLink">Helpful Tips – At a Glance</a></div></li><li class="navMenu navMenu" data-navmenu="3"><a href="/patient-FAQs.html"><p>FAQs</p></a><div class="navSubMenu" data-navsubmenu="3"></div></li><li class="navMenu navMenu" data-navmenu="4"><a href="/patient-access-and-support.html"><p>Access & Support</p></a><div class="navSubMenu" data-navsubmenu="4"></div></li></ul></nav></div><!-- Mobile Nav --><div class="header__mobile_nav" data-btn="mobile_menu_btn"><div></div></div></div></header><!-- Mobile Menu --><div class="header__mobile_menu" data-menu="mobileNav"><nav><ul><li class="navMenu navMenu-mob" data-navmenu="0-mob"><a href="/patient-understanding-pah.html"><p>Understanding PAH</p></a><div class="navSubMenu" data-navsubmenu="0-mob"></div></li><li class="navMenu navMenu-mob" data-navmenu="1-mob"><a href="/patient-what-is-veletri.html"><p>What is VELETRI<sup>&reg;</sup>?</p><img src="assets/images/arrow.svg" alt="arrow" class="only-mobile" loading="lazy"></a><div class="navSubMenu subTabs" data-navsubmenu="1-mob"><a href="/patient-what-is-veletri.html#howWorks" class="subMenuLink">How VELETRI<sup>&reg;</sup> works </a><a href="/patient-what-is-veletri.html#sideEffects" class="subMenuLink">Side effects of VELETRI<sup>&reg;</sup></a></div></li><li class="navMenu navMenu-mob" data-navmenu="2-mob"><a href="/patient-taking-veletri.html"><p>Taking VELETRI<sup>&reg;</sup></p><img src="assets/images/arrow.svg" alt="arrow" class="only-mobile" loading="lazy"></a><div class="navSubMenu subTabs" data-navsubmenu="2-mob"><a href="/patient-taking-veletri.html#startingVeletri" class="subMenuLink">Starting VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#preparingStoring" class="subMenuLink">Storing VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#usingVeletri" class="subMenuLink">Using VELETRI<sup>&reg;</sup> </a><a href="/patient-taking-veletri.html#helpFul" class="subMenuLink">Helpful Tips – At a Glance</a></div></li><li class="navMenu navMenu-mob" data-navmenu="3-mob"><a href="/patient-FAQs.html"><p>FAQs</p></a><div class="navSubMenu" data-navsubmenu="3-mob"></div></li><li class="navMenu navMenu-mob" data-navmenu="4-mob"><a href="/patient-access-and-support.html"><p>Access & Support</p></a><div class="navSubMenu" data-navsubmenu="4-mob"></div></li><li class="extra-nav-mobile first"><a href="https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/VELETRI-pi.pdf" target="_blank">Full Prescribing Information</a></li><li class="extra-nav-mobile"><a href="https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/VELETRI-pi-es.pdf" target="_blank">Información en Español</a></li><li class="extra-nav-mobile"><a } href="#ISI">Important Safety Information</a></li><li class="extra-nav-mobile"><a open-interstitial="https://www.janssen.com/us/legal-notice" href="">Legal Notice</a></li><li class="extra-nav-mobile">

47<a open-interstitial="https://www.janssencarepath.com/patient/veletri/patient-support" href="">J&amp;J withMe</a></li><li class="extra-nav-mobile"><a } href="contact-us.html">Contact Us</a></li><li class="extra-nav-mobile"><a open-interstitial-hcp="hcp/" href="">Healthcare Professionals</a></li></ul></nav></div></section><header class="hero-content hero-content-alt"><div class="container"><h1>Treating PAH isn't easy. <span>VELETRI<sup class="r-ball">&reg;</sup> is an intravenous (IV) PAH medication that can be administered at home.</span></h1></div><img src="/assets/images/patient/home/bot_header.webp" alt="VELETRI intravenous delivery system for home-based PAH treatment" loading="lazy"></header></div><div class="patient"><!-- HTML GOES HERE --><div class="home-page"><main class="main-content"><div class="study-design"><div class="container"><h3>IV therapy administered at home</h3><p>VELETRI<sup>&reg;</sup> is a prescription medicine that is given intravenously (in a vein). It is used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH) (WHO Group 1), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. VELETRI<sup>&reg;</sup> may improve your ability to exercise as measured by how far you can walk in 6 minutes (6-minute walk test).</p><p>Studies showing VELETRI<sup>&reg;</sup> is effective mainly included patients with New York Heart Association (NYHA) Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors or connective tissue disease.</p><!--
48                    <p>Epoprostenol was studied in 2 prospective, <span class="nowrap">open-label</span>, randomized trials of 8 and <span class="nowrap">12 weeks</span> duration (pooled data results) in patients with idiopathic pulmonary arterial hypertension (IPAH) or heritable PAH (HPAH). Patients were New York Heart Association (NYHA) Functional Class III or IV, except for <span class="nowrap">2 patients</span> who were NYHA Functional <span class="nowrap">Class II.</span></p>
49                <p class="dosage">Dosage of epoprostenol was determined as described under dosage and administration and averaged <span class="nowrap">9.2 ng/kg/min</span> at study's end. In the <span class="nowrap">12-week</span>, <span class="nowrap">open-label</span>, randomized, parallel study:</p>
50                <small><sup>†</sup>Conventional therapy could include anticoagulants, oral vasodilators, supplemental oxygen, digoxin, and/or diuretics.<sup>1,2</sup></small>
51                --></div></div><div class="veletri-offers"><div class="container"><h3>VELETRI<sup>&reg;</sup> offers:</h3><div class="box-img-text"><div left><img src="/assets/images/patient/home/circle_1.png" alt="" width="363" height="363" loading="lazy"></div><div right><p><b>The same active pharmaceutical ingredient as Flolan<sup>&reg;</sup> (epoprostenol sodium)<sup>1,2</sup></b></p><hr><p>The active ingredient of VELETRI<sup>&reg;</sup> (epoprostenol) for Injection is epoprostenol, which is a prostacyclin. VELETRI<sup>&reg;</sup> adds back the prostacyclin your body is missing. Epoprostenol opens up, or dilates, the blood vessels in the lungs. Once the blood vessels are open, oxygen-rich blood can flow more easily.<sup>3</sup></p><p>Unlike Flolan<sup>&reg;</sup>, VELETRI<sup>&reg;</sup> can be mixed (reconstituted) with either Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP, both of which are commercially available.<sup>1</sup> Flolan<sup>&reg;</sup> requires the use of its own diluent when preparing.<sup>2</sup></p><p>Important: VELETRI<sup>&reg;</sup> is stable only when reconstituted as directed using Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. VELETRI<sup>&reg;</sup> must not be reconstituted or mixed with any other intravenous medications or solutions prior to or during drug administration. The same solution must be used for both reconstituting and diluting VELETRI<sup>&reg;</sup>. Do not combine sterile water with normal saline when preparing VELETRI<sup>&reg;</sup>.</p></div></div><div class="box-img-text"><div left><img src="/assets/images/patient/home/circle_2.png" alt="" width="363" height="363" loading="lazy"></div><div right><p><b>24-hour room temperature (68°F to 77°F/20°C to 25°C) stability at all concentrations</b></p></div></div><div class="box-img-text"><div left><img src="/assets/images/patient/home/circle_3.png" alt="" width="363" height="363" loading="lazy"></div><div right><p><b>The option to prepare a week’s worth of doses (up to 8 cassettes) at one time to keep in the refrigerator (36°F to 46°F/2°C to 8°C)<sup>1</sup></b></p></div></div></div></div><div blue-line></div><div pink-line></div><div class="container"><div class="references"><p><span class="title">References:</span> <span class="reference_item"><b>&nbsp;1.</b> VELETRI<sup>&reg;</sup> (epoprostenol) for Injection Full Prescribing Information. Actelion Pharmaceuticals US, Inc.</span> <span class="reference_item"><b>2.</b> FLOLAN<sup>&reg;</sup> (epoprostenol) for Injection Full Prescribing Information. GlaxoSmithKline.</span> <span class="reference_item"><b>3.</b> McLaughlin V. Pulmonary hypertension. In: Goldman L, Schafer AI, eds. <i>Goldman’s Cecil Medicine.</i> 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:389-397.</span></p></div></div></main></div><div class="patient"><!-- ISI --><div class="isi-custom-content" id="ISI"><div class="container"><div data-controller="IsiComponent" data-source="api" data-isi-expand-cta="<span>+</span>" data-isi-close-cta="<span>-</span>" data-isi-scroll-on-expand="false" data-isi-lang="English" data-isi-country="unitedStates" data-isi-brand="VELETRI" data-isi-audience="Consumer" data-isi-env="prod"><!-- Static --><div class="isi-main" id="ISI"><div id="janssen-isi-content-wrapper" class="isi-main__container"></div></div><!-- /Static --><!-- Pinned --><div class="isi-main" id="pinned-isi"><div id="pinned-isi-content-wrapper" class="isi-main__container"></div><div id="expand-dsk-btn" class="isi-main__expand"><span>+</span></div></div><!-- /Pinned --></div></div></div><!-- /ISI --><footer data-controller="footer">

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