1<!DOCTYPE html> 2<html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# " class="no-js"> 3 4 5<meta http-equiv="content-type" content="text/html;charset=UTF-8" /> 6<head> 7
7<script type="text/javascript"> 8 var otsuka_dl = { 9 "page": { 10 "business_function": "commercial", 11 "therapeutic_area": "nephrology", 12 "business_affiliate": "oapi", 13 "site_language": "english", 14 "brand_name": "jynarque", 15 "side_of_brand": "dtc", 16 "indication": "autosomal dominant polycystic kidney disease (adpkd)", 17 "root_domain": "jynarque.com" 18 } 19}; 20 </script>
20 21 22 <meta charset="utf-8" /> 23<meta name="description" content="Learn about rapidly progressing & at risk of rapidly progressing ADPKD. See FULL PRESCRIBING INFORMATION, including BOXED WARNING and MEDICATION GUIDE." /> 24<link rel="canonical" href="understanding-adpkd-progression.html" /> 25<meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> 26<meta name="MobileOptimized" content="width" /> 27<meta name="HandheldFriendly" content="true" /> 28<meta name="viewport" content="width=device-width, initial-scale=1.0" />
29<script src="https://cdn.cookielaw.org/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="0191263f-61d3-7be6-925b-3177207e1849"></script>
vendor: 1 bytes, line 29
29
30<script type="text/javascript" defer="defer"> 31 function waitForElm(selector) { 32 return new Promise(function (resolve) { 33 if (document.querySelector(selector)) { 34 return resolve(document.querySelector(selector)); 35 } 36 37 const observer = new MutationObserver(function (mutations) { 38 if (document.querySelector(selector)) { 39 observer.disconnect(); 40 resolve(document.querySelector(selector)); 41 } 42 }); 43 44 observer.observe(document.body, { 45 childList: true, 46 subtree: true 47 }); 48 }); 49 } 50 51 function oneTrustAddFont() { 52 const link = document.createElement('link'); 53 link.rel = 'stylesheet'; 54 link.type = 'text/css'; 55 link.href = 'https://fonts.googleapis.com/css?family=Montserrat'; 56 document.getElementsByTagName('HEAD')[0].appendChild(link); 57 } 58 59 function addMeta() { 60 const meta = document.createElement('meta'); 61 meta.name = 'viewport'; 62 meta.content = 'width=device-width, initial-scale=1.0'; 63 document.getElementsByTagName('head')[0].appendChild(meta); 64 } 65 66 function oneTrustBannerFooterFix() { 67 const divSelector = document.querySelector('#onetrust-button-group-parent'); 68 const elementDiv = document.createElement('div'); 69 elementDiv.className = 'ontrust_logo'; 70 elementDiv.innerHTML = "<div class='green-logo'> onetrust</div><div class='text-logo'>Powered by</div>"; 71 divSelector.parentNode.insertBefore(elementDiv, divSelector.nextSibling); 72 73 document.getElementsByClassName('ot-pc-footer-logo')[0].children[0].removeAttribute('href'); 74 } 75 76 function oneTrustBannerOtherFix() { 77 var p = document.querySelectorAll('.ot-accordion-layout p'); 78 Array.prototype.forEach.call(p, function(el) { 79 el.innerHTML = el.innerHTML.replace(/ /gi, ''); 80 }); 81 82 let tabindex = 2; 83 document.querySelectorAll('#onetrust-button-group button, #onetrust-button-group input').forEach(function (element) { 84 element.setAttribute('tabindex', String(tabindex)); 85 if (tabindex === 2) { 86 tabindex = 1; 87 } else if (tabindex === 1) { 88 tabindex = 3; 89 } else { 90 tabindex++; 91 } 92 }); 93 document.querySelector('#onetrust-policy-text a').setAttribute('tabindex', 1); 94 } 95 96 function oneTrustSettingsButtonFix() { 97 const acceptBtn = document.getElementById('accept-recommended-btn-handler'); 98 const rejectBtn = document.getElementsByClassName('ot-pc-refuse-all-handler')[0]; 99 const container = document.getElementsByClassName('ot-btn-container')[0]; 100 container.prepend(acceptBtn, rejectBtn); 101 } 102 103 function oneTrustSettingsOtherFix() { 104 const modelElement = document.getElementById('onetrust-pc-sdk'); 105 document.addEventListener('focus', function (e) { 106 const focusableElements = modelElement.querySelectorAll('a[href], area[href], input:not([disabled]), select:not([disabled]), textarea:not([disabled]), button:not([disabled]), iframe, object, embed, *[tabindex], *[contenteditable]'); 107 if (!Array.from(focusableElements).includes(e.target)) { 108 Array.from(focusableElements)[0].focus(); 109 } 110 }, true); 111 } 112 113 oneTrustAddFont(); 114 addMeta(); 115 116 document.addEventListener('DOMContentLoaded', function () { 117 waitForElm('#onetrust-banner-sdk').then(function () { 118 oneTrustBannerFooterFix(); 119 oneTrustBannerOtherFix(); 120 }); 121 122 waitForElm('#onetrust-pc-sdk').then(function () { 123 oneTrustSettingsButtonFix(); 124 oneTrustSettingsOtherFix(); 125 }); 126 }); 127</script>
vendor: 1 bytes, line 127
127
128<script></script>
vendor: 1 bytes, line 128
128
129<script src="https://assets.adobedtm.com/3f0d2e2dbd42/313fd7baa8af/launch-bacdce8b01b7.min.js" type="text/javascript" async></script>
129 130<link rel="icon" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/favicon.ico" type="image/vnd.microsoft.icon" />
131<script type="application/ld+json">{"@context": "https://schema.org", 132"@type": "MedicalWebPage", 133"audience": "Patient", 134"specialty": "Renal", 135"url": "https://www.jynarque.com/understanding-adpkd-progression", 136"headline": ["Understanding ADPKD & Progression","The truth about autosomal dominant polycystic kidney disease (ADPKD) progression is that it looks different for everyoneâeven within the same family","With rapidly progressing ADPKD, kidney function worsens and cysts grow more quickly, leading to early kidney failure","Why does kidney size matter?","Assessing your ADPKD progression","Is your eGFR rapidly declining? Your ADPKD could already be rapidly progressing.","Is your eGFR stable? You could still be at risk of rapidly progressing ADPKD.","Be Proactive","How is kidney size used to predict ADPKD progression?"], 137"abstract": "Rapidly progressing ADPKD vs being at risk for rapidly progressing ADPKD", 138"description": ["A parent with ADPKD has a 50% chance of passing it on to each child","It is important to know that ADPKD disease progression and symptoms vary amongst patients","According to the Mayo Clinic ADPKD study, out of 538 patients, ~2/3 of this group were at risk for rapid progression","In ADPKD, kidney growth caused by cysts often happens before your kidney function decline appears. Kidney function, measured by estimated glomerular filtration rate (eGFR), may remain stable while your kidneys continue to grow and can mask the irreversible damage. Because of this, kidney size, or total kidney volume (TKV), is the best predictor of ADPKD progression.","Your nephrologist can use an ultrasound, magnetic resonance imaging (MRI), or computed tomography (CT) to measure your kidney size and determine your risk of ADPKD progression.","Your nephrologist will take your total kidney volume (TKV) and adjust it based on your height to determine your risk of disease progression. This measurement is called a height-adjusted total kidney volume, or hTKV.","For example, two people may have the same size kidneys, but the shorter person may be at greater risk for rapid disease progression. Or, two people may have the same size kidneys and same height, but if one is younger, that person may be at risk for faster disease progression.","After determining your hTKV, your nephrologist may use your age and hTKV on a tool called the Mayo Imaging Classification chart to help predict your rate of disease progression.","A person with ADPKD is considered to be rapidly progressing when their eGFR, a test result that measures how well the kidneys work, declines quickly relative to their age.","If your current eGFR falls on the chart below and you are experiencing an eGFR decline ⥠3 mL/min/1.73 m2 per year over a period of 4 years or more, your ADPKD is rapidly progressing.","There are a number of factors that may put someone already living with ADPKD at risk of rapid ADPKD progression.","These may include: Kidneys that are bigger than normal for a person's age with ADPKD (high total kidney volume), Certain types of genetic mutations, Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58, High blood pressure that started before the age of 35, Blood in urine (hematuria), cyst infections, or flank pain related to cysts, before age 35, Being overweight, with a body mass index â¥25 kg/m2, Protein and albumin in urine (proteinuria and albuminuria).","Wherever you are in your ADPKD journey, it's important to talk with your nephrologist to develop an appropriate treatment plan for your individual situation.","The sooner you start, the sooner you can help take control of your ADPKD and may start to experience the benefits of slowing down your disease progression. Don't wait, take the first step today. Make a plan to have a discussion about what you can do to help manage your ADPKD at your next appointment."], 139"name": "Understanding ADPKD & Progression", 140"breadcrumb": 141{"@type": "BreadcrumbList", 142"itemListElement": [{ 143"@type": "ListItem", 144"position": 1, 145"item": { 146"@id": "https://www.jynarque.com/", 147"name": "Homepage"}}, 148{"@type": "ListItem", 149"position": 2, 150"item": { 151"@id": "https://www.jynarque.com/understanding-adpkd-progression", 152"name": "Understanding ADPKD & Progression"}}]}, 153"mainContentOfPage": 154{"@type": "WebPageElement", 155"potentialAction": [{ 156"@type": "Action", 157"name": "See if JYNARQUE is right for you", 158"description": "If you have any of these risk factors", 159"url": "https://www.jynarque.com/is-jynarque-for-you"}]}, 160"about": [ 161{"@type": "MedicalCondition", 162"name": "autosomal dominant polycystic kidney disease", 163"description": ["A person with ADPKD is considered to be already rapidly progressing when their eGFR (a test result that measures how well the kidneys work) declines quickly. eGFR is declining quickly when it drops: â¥5 mL/min/1.73 m2 within 1 year OR â¥2.5 mL/min/1.73 m2/year over a 5-year period","There are a number of factors that may put someone already living with ADPKD at risk of rapid ADPKD progression. These may include: A high total kidney volume (kidneys that are larger than normal for a person with ADPKD), Blood in urine (hematuria), cyst infections, or flank pai related to cysts, before age 35, Certain types of genetic mutations, Being overweight, with a body mass index â¥25 kg/m2, Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58, Protein and albumin in urine (proteinuria and albuminuria), and High blood pressure that started before the age of 35"], 164"alternateName": "ADPKD"}, 165{"@type": "MedicalTherapy",
166"description": ["Wherever you are in your ADPKD journey, it's important to talk with your nephrologist to develop an appropriate treatment plan for your individual situation.","The sooner you start, the sooner you can help take control of your ADPKD and may start to experience the benefits of slowing down your disease progression. Don't wait, take the first step today. Make a plan to have a discussion about what you can do to help manage your ADPKD at your next appointment."], 167"guideline": ["It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver: before you start taking JYNARQUE, at 2 weeks and 4 weeks after you start treatment with JYNARQUE, then monthly for 18 months during treatment with JYNARQUE, and every 3 months from then on","Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the JYNARQUE Risk Evaluation and Mitigation Strategy (REMS) Program.","Do not take JYNARQUE if you: have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease, cannot feel if you are thirsty or cannot replace fluids by drinking, have been told that the amount of sodium (salt) in your blood is too high or too low, are dehydrated, are allergic to tolvaptan or any of the ingredients in JYNARQUE, are unable to urinate"], 168"adverseOutcome": "The most common side effects of JYNARQUE are: thirst and increased fluid intake and making large amounts of urine, urinating often, and urinating at night", 169"seriousAdverseOutcome": "JYNARQUE may cause serious side effects, including: Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration). In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms: dizziness, fainting, weight loss, a change in the way your heart beats, feeling confused or weak", 170"contraindication": ["Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines. Do not start taking a new medicine without talking to your healthcare provider","Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood."], 171"recognizingAuthority": 172{"@type": "Organization", 173"name": "U.S. Food and Drug Administration", 174"alternateName": "FDA", 175"url": "https://www.fda.gov/"}}, 176{"@type": "Drug", 177"Name": "JYNARQUE®", 178"nonProprietaryName": ["JYNARQUE","tolvaptan"], 179"activeIngredient": "tolvaptan", 180"alternateName": "tolvaptan", 181"dosageForm": "tablet", 182"administrationRoute": "oral", 183"doseSchedule": [ 184{"@type": "DoseSchedule", 185"frequency": "twice daily", 186"doseUnit": "mg", 187"doseValue": ["60,90,120"], 188"targetPopulation": ["JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children."]}], 189"offers": { 190"@type": "Offer", 191"price": "10", 192"priceCurrency": "USD", 193"url": "https://www.jynarque.com/copay-assistance"}, 194"pregnancyWarning": "Tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant", 195"breastfeedingWarning": "Tell your healthcare provider about all your medical conditions, including if you: are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time", 196"warning": "Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.", 197"image": "https://www.jynarque.com/sites/g/files/qhldwo7701/themes/site/themes/custom/jynarque_hcc_2021/jynarque-logo.svg", 198"manufacturer":{ 199"@type": "Organization", 200"name": "Otsuka America Pharmaceutical, Inc.",
201"logo": "http://www.otsuka-us.com/"}}]}</script>
201 202 203 <title>Understanding ADPKD & Progression | JYNARQUE® (tolvaptan) tablets</title> 204 <link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/core.css" /> 205<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/controlgroup.css" /> 206<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/checkboxradio.css" /> 207<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/resizable.css" /> 208<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/button.css" /> 209<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/dialog.css" /> 210<link rel="stylesheet" media="all" href="core/misc/components/progress.module.css" /> 211<link rel="stylesheet" media="all" href="core/misc/components/ajax-progress.module.css" /> 212<link rel="stylesheet" media="all" href="core/modules/system/css/components/align.module.css" /> 213<link rel="stylesheet" media="all" href="core/modules/system/css/components/fieldgroup.module.css" /> 214<link rel="stylesheet" media="all" href="core/modules/system/css/components/container-inline.module.css" /> 215<link rel="stylesheet" media="all" href="core/modules/system/css/components/clearfix.module.css" /> 216<link rel="stylesheet" media="all" href="core/modules/system/css/components/details.module.css" /> 217<link rel="stylesheet" media="all" href="core/modules/system/css/components/hidden.module.css" /> 218<link rel="stylesheet" media="all" href="core/modules/system/css/components/item-list.module.css" /> 219<link rel="stylesheet" media="all" href="core/modules/system/css/components/js.module.css" /> 220<link rel="stylesheet" media="all" href="core/modules/system/css/components/nowrap.module.css" /> 221<link rel="stylesheet" media="all" href="core/modules/system/css/components/position-container.module.css" /> 222<link rel="stylesheet" media="all" href="core/modules/system/css/components/reset-appearance.module.css" /> 223<link rel="stylesheet" media="all" href="core/modules/system/css/components/resize.module.css" /> 224<link rel="stylesheet" media="all" href="core/modules/system/css/components/system-status-counter.css" /> 225<link rel="stylesheet" media="all" href="core/modules/system/css/components/system-status-report-counters.css" /> 226<link rel="stylesheet" media="all" href="core/modules/system/css/components/system-status-report-general-info.css" /> 227<link rel="stylesheet" media="all" href="core/modules/system/css/components/tablesort.module.css" /> 228<link rel="stylesheet" media="all" href="modules/contrib/jquery_ui/assets/vendor/jquery.ui/themes/base/core.css" /> 229<link rel="stylesheet" media="all" href="modules/contrib/jquery_ui/assets/vendor/jquery.ui/themes/base/datepicker.css" /> 230<link rel="stylesheet" media="all" href="core/modules/ckeditor5/css/ckeditor5.dialog.fix.css" /> 231<link rel="stylesheet" media="all" href="modules/custom/paragraph/otsuka_paragraphs/css/base.css" /> 232<link rel="stylesheet" media="all" href="modules/custom/paragraph/otsuka_paragraphs/modules/otsuka_paragraphs_block/css/components/block-paragraph.css" /> 233<link rel="stylesheet" media="all" href="modules/custom/paragraph/otsuka_paragraphs/modules/otsuka_paragraphs_link/css/components/link-paragraph.css" /> 234<link rel="stylesheet" media="all" href="modules/custom/paragraph/otsuka_paragraphs/modules/otsuka_paragraphs_text/css/components/text-paragraph.css" /> 235<link rel="stylesheet" media="all" href="modules/custom/paragraph/otsuka_paragraphs/modules/otsuka_paragraphs_wrapper/css/components/wrapper.css" /> 236<link rel="stylesheet" media="all" href="modules/custom/otsuka_privacy_compliant_media/css/otsuka_privacy_compliant_media.css" /> 237<link rel="stylesheet" media="all" href="core/assets/vendor/jquery.ui/themes/base/theme.css" /> 238<link rel="stylesheet" media="all" href="modules/contrib/extlink/extlink.css" /> 239<link rel="stylesheet" media="all" href="modules/contrib/jquery_ui/assets/vendor/jquery.ui/themes/base/theme.css" /> 240<link rel="stylesheet" media="all" href="modules/custom/pharma_isi/js/3rd-party/mCustomScrollbar/jquery.mCustomScrollbar.css" /> 241<link rel="stylesheet" media="all" href="modules/custom/otsuka_sfmc_registration/css/dist/otsuka_sfmc_registration.css" /> 242<link rel="stylesheet" media="all" href="modules/contrib/paragraphs/css/paragraphs.unpublished.css" /> 243<link rel="stylesheet" media="all" href="modules/contrib/simple_popup_blocks/css/simple_popup_blocks.css" />
244<link rel="stylesheet" media="all" href="modules/custom/pharma_isi/css/pharma_isi_drawer.css" /> 245<link rel="stylesheet" media="all" href="modules/custom/pharma_isi/css/pharma_isi_inline.css" /> 246<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.utility.css" /> 247<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.modal.css" /> 248<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.navigation.css" /> 249<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.alert.css" /> 250<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.button.css" /> 251<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/page/page.special.css" /> 252<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/lib/reset.css" /> 253<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.critical.css" /> 254<link rel="stylesheet" media="all" href="https://fonts.googleapis.com/css2?family=Lato:ital,wght@0,300;0,400;0,700;0,900;1,300;1,400&display=swap" /> 255<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/node/node.landing-page.css" /> 256<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/bootstrap/bootstrap.collapse.css" /> 257<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/block/gs-animation/block.gs-animation.css" /> 258<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.range.css" /> 259<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/block/block.system-branding-block.css" /> 260<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.simple-text-option.css" /> 261<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.simple-text-option-2024.css" /> 262<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.footnote.css" /> 263<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.link-paragraph.css" /> 264<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.percentage.css" /> 265<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.border-blue-block.css" /> 266<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.blue-rectangle-block.css" /> 267<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.border-two.css" /> 268<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.triangle-corners-2-subitems.css" /> 269<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.online-resources.css" /> 270<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.fw-image.css" /> 271<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.image-with-quote.css" /> 272<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/component.video-accordions.css" /> 273<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/otsuka-isi.css" /> 274<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/component/interstitials.css" /> 275<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/form.css" /> 276<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/form-errors.css" /> 277<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/menu/menu-sticky.css" /> 278<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/menu/menu.main.css" /> 279<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/paragraph/paragraph.border_box_text.css" /> 280<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/paragraph/paragraph.text.css" /> 281<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/paragraph/paragraph.understanding_adpkd.css" /> 282<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/paragraph/paragraph.wrapper.css" /> 283<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/region/region.header-bottom.css" /> 284<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/region/region.header-info.css" /> 285<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/region/region.header-middle.css" /> 286<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/region/region.mobile-menu.css" /> 287<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/region/region.visually-hidden.css" /> 288<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/base/focus.css" /> 289<link rel="stylesheet" media="all" href="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/css/global.css" /> 290 291
291<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/37481","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"ajaxPageState":{"libraries":"eJyFU-12wyAIfaEkbnshD0ZqbFWc6Nbs6Wc-dtqutv1jhHsDcgHQpFA6KGGcBFwZHZ4zpgBOOhtOMlIsUWgLjswCLU6hU4nght3sDJFxKDMYYerx3x7gCOdbp--Oc4D0WVBO4yg_3j7ehXI0ngbDPQTrIVsKD0k8c0bfqwRB22D61dtgG0cKXM95ru80DYLHUAYPtpXKk6462J_UwELFBrdnj2CwwYmQwCSIEw-KUo0lFZ1lrqI9J79mlFCjcd7SS9DxpJ__8F0_EVuFJDRV6GFCqCF7RTlTqze3NBsO9JLkrdaupctO86Ssw37pwGPSl-UCzs39VKNh6ChzOYG8lCYUMN675ToR27Q00HWI19G9xxb5xdqDe2zXUfzpuTP44Ee5vJhzWgdXPAL6mDAmGpG5uypi36ebFseinOUJdRcnSB6kZSsu146tj3Wf1v3cymXR8HXbrqw6_QLCtoKI","theme":"jynarque_hcc_2021","theme_token":null},"ajaxTrustedUrl":[],"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-K4DRM2S"]},"external_link_popup":{"whitelist":"","width":"85%","popups":[{"id":"leaving_the_patients_site","name":"3. Leaving the patients site","status":true,"weight":-10,"close":true,"title":"-","body":"\u003Ch2\u003EYou are now leaving the patient site.\u003C\/h2\u003E\n\n\u003Cp\u003EThe section you selected contains information intended for US healthcare professionals only. Please certify that you are a US healthcare professional by clicking the link below.\u0026nbsp;\u003C\/p\u003E","labelyes":"Yes, I am a US healthcare professional","labelno":"No, I am not a US healthcare professional","domains":"jynarquehcp.com","target":"_self"},{"id":"otsuka_controlled_website","name":"2. Otsuka Controlled Website","status":true,"weight":-9,"close":true,"title":"-","body":"\u003Ch2\u003EYou are now leaving JYNARQUE.com.\u003C\/h2\u003E\n\n\u003Cp\u003EClick \u2018I agree\u2019 to proceed to an Otsuka-controlled website.\u003C\/p\u003E","labelyes":"I agree","labelno":"","domains":"otsukapatientassistance.com\r\notsukapatientsupport.com\r\njynarquerems.com\r\nadpkdpeermentorprogram.com\r\notsuka-us.com","target":"_self"},{"id":"default","name":"1. Default","status":true,"weight":-8,"close":true,"title":"-","body":"\u003Ch2\u003EYou are now leaving JYNARQUE.com.\u003C\/h2\u003E\n\n\u003Cp\u003EOtsuka is not responsible for the content on a third-party website.\u003C\/p\u003E","labelyes":"OK","labelno":"","domains":"*","target":"_self"}]},"simple_popup_blocks":{"settings":[{"langcode":"en","uid":"covidpopupblock","type":0,"css_selector":"1","identifier":"block-covidpopupblock","layout":"4","visit_counts":"0","overlay":"1","trigger_method":"1","trigger_selector":".covid-popup","delay":0,"minimize":false,"close":"1","use_time_frequency":false,"width":"400","cookie_expiry":0,"status":"1","escape":"1"}]},"data":{"extlink":{"extTarget":true,"extTargetNoOverride":false,"extNofollow":false,"extNoreferrer":true,"extFollowNoOverride":false,"extClass":"0","extLabel":"(link is external)","extImgClass":false,"extSubdomains":true,"extExclude":"","extInclude":"","extCssExclude":"","extCssExplicit":"","extAlert":false,"extAlertText":"This link will take you to an external web site. We are not responsible for their content.","mailtoClass":"0","mailtoLabel":"(link sends email)","extUseFontAwesome":false,"extIconPlacement":"append","extFaLinkClasses":"fa fa-external-link","extFaMailtoClasses":"fa fa-envelope-o","whitelistedDomains":[]}},"privacy_compliant_media_settings":{"enabled":1,"general":{"error_cmp_not_found":"Consent management is currently disabled, website functionality may be affected. Please try reloading the page."},"youtube":{"enabled":1,"cat_id":"C0002","dependent_cat_id":"C0004","modal":{"description":"To start your video we need your permission to use YouTube cookies. These cookies help us make other video recommendations specific to your interests.","consent_label":"Allow YouTube cookies","morelink_label":"Learn more about cookies","morelink_url":"javascript:OneTrust.ToggleInfoDisplay();"},"overlay_image":null},"vimeo":{"enabled":1,"cat_id":"C0008","dependent_cat_id":"C0004","modal":{"description":"By clicking \u0027Accept\u0027, you will enable functional cookies that are necessary for the video\u0027s playback on this platform. These
291cookies can be reviewed \u003Ca href=\u0022javascript:OneTrust.ToggleInfoDisplay();\u0022\u003Ehere\u003C\/a\u003E and adjusted at any time by clicking the shield above. Want to know more? View our \u003Ca target=\u0022_blank\u0022 href=\u0022https:\/\/www.otsuka-us.com\/privacy-policy\u0022\u003EPrivacy Notice\u003C\/a\u003E.\r\n\u003Ca class=\u0022otsuka-pcm-consent-link\u0022 href=\u0022javascript:OneTrust.ToggleInfoDisplay();\u0022 role=\u0022button\u0022 aria-label=\u0022Privacy Notice\u0022\u003EPrivacy Notice\u003C\/a\u003E","consent_label":"Accept","morelink_label":"","morelink_url":""},"overlay_image":null},"buzzsprout_podcasts":{"enabled":1,"cat_id":"C0002","modal":{"description":"To start your podcast we need your permission to contact Buzzsprout. This allows us to place a podcast player widget on the page.","consent_label":"Allow Buzzsprout player","morelink_label":"","morelink_url":""},"overlay_image":null},"orbita_live_chat":{"enabled":1,"cat_id":"C0010","widget":{"wrapper_id":"chatbot-wrapper","html":"\u003Cbutton class=\u0022chat-icon show\u0022 aria-label=\u0022Show Chatbot\u0022\u003E\r\n\t\u003Cdiv\u003E\r\n\t\u003Csvg xmlns=\u0022http:\/\/www.w3.org\/2000\/svg\u0022 width=\u0022125.722\u0022 height=\u0022124.325\u0022 viewBox=\u00220 0 125.722 124.325\u0022\u003E\r\n \u003Cg data-name=\u0022Group 1412\u0022\u003E\r\n \u003Cpath data-name=\u0022Path 1000\u0022 d=\u0022M89.8 75.9v-.1a41.662 41.662 0 1 0-70.6 36.8l.9.9a24.062 24.062 0 0 1-8 12.9l-.1.1a4.741 4.741 0 0 0-1 1 2.784 2.784 0 0 0 .7 3.5l.2.2 1 .4a28.251 28.251 0 0 0 5 .5 23.368 23.368 0 0 0 19.3-9 42.871 42.871 0 0 0 27.4-1.5 41.323 41.323 0 0 0 25.2-45.7zM62.3 116a37.874 37.874 0 0 1-13.7 2.6 41.373 41.373 0 0 1-9.9-1.3l-4-1.1-2.5 3.2a17.642 17.642 0 0 1-11.5 6.6 31.827 31.827 0 0 0 5.2-11l.8-3.4-2.6-2.4a5.716 5.716 0 0 1-.8-.7 35.445 35.445 0 1 1 60.3-31.4v.1A34.833 34.833 0 0 1 62.3 116z\u0022 style=\u0022fill:#fff\u0022 transform=\u0022translate(-7.118 -7.793)\u0022\/\u003E\r\n \u003C\/g\u003E\r\n \u003Cpath data-name=\u0022Path 1001\u0022 d=\u0022m127.2 105.8-.2-.1a29.239 29.239 0 0 1-9.3-15 10.949 10.949 0 0 1 1.1-1 48.437 48.437 0 0 0 12.6-45.8 48.8 48.8 0 0 0-78.7-24.5 47.123 47.123 0 0 0-14.2 21 44.209 44.209 0 0 1 10.4-1.2 44.819 44.819 0 0 1 11.5 1.5 45.477 45.477 0 0 1 17.7 9.2 44.633 44.633 0 0 1 14.7 25.2v.1a44.388 44.388 0 0 1-4.2 28.1 50.124 50.124 0 0 0 9.4-1.7 27.114 27.114 0 0 0 22.4 10.5 27.841 27.841 0 0 0 5.8-.6l1.1-.4.3-.3a3.36 3.36 0 0 0 .8-4.1c-.3-.2-.7-.6-1.2-.9z\u0022 style=\u0022fill:#fff\u0022 transform=\u0022translate(-7.118 -7.793)\u0022\/\u003E\r\n \u003Cpath data-name=\u0022Path 1002\u0022 d=\u0022m127.2 105.8-.2-.1a29.239 29.239 0 0 1-9.3-15 10.949 10.949 0 0 1 1.1-1 48.437 48.437 0 0 0 12.6-45.8 48.8 48.8 0 0 0-78.7-24.5 47.524 47.524 0 0 0-15.9 27.3v.1c-.2 1.2-.4 2.4-.5 3.6a35.22 35.22 0 0 1 12.6-2.3 35.551 35.551 0 0 1 35 28.7v.1a34.871 34.871 0 0 1-5.7 26.2 50.989 50.989 0 0 0 19.8-1.4 27.114 27.114 0 0 0 22.4 10.5 27.841 27.841 0 0 0 5.8-.6l1.1-.4.3-.3a3.36 3.36 0 0 0 .8-4.1 6.343 6.343 0 0 0-1.2-1z\u0022 style=\u0022fill:#fff\u0022 transform=\u0022translate(-7.118 -7.793)\u0022\/\u003E\r\n \u003Cg data-name=\u0022Group 1414\u0022\u003E\r\n \u003Cg data-name=\u0022Group 1413\u0022 style=\u0022opacity:.4\u0022\u003E\r\n \u003Cpath data-name=\u0022Path 1003\u0022 d=\u0022M89.8 75.9v-.1a41.824 41.824 0 0 0-52.4-31.9c-.3 1-.5 2-.7 3v.1c-.2 1.2-.4 2.4-.5 3.6a35.22 35.22 0 0 1 12.6-2.3 35.551 35.551 0 0 1 35 28.7v.1a34.871 34.871 0 0 1-5.7 26.2 53.222 53.222 0 0 0 6.9.4 40.515 40.515 0 0 0 4.8-27.8z\u0022 style=\u0022fill:#103b71\u0022 transform=\u0022translate(-7.118 -7.793)\u0022\/\u003E\r\n \u003C\/g\u003E\r\n \u003C\/g\u003E\r\n\u003C\/svg\u003E\r\n\t\u003Cp\u003EChat\u003C\/p\u003E\r\n\t\u003C\/div\u003E\r\n\t\u003Cspan class=\u0022divider\u0022\u003E\u003C\/span\u003E\r\n\u003C\/button\u003E","css":".chat-icon {\r\n width: 97px;\r\n\tdisplay: flex;\r\n\tflex-direction: row;\r\n\talign-items: center;\r\n\tjustify-content: center;\r\n\tmargin: auto;\r\n\tcolor: #fff;\r\n\tcursor: pointer;\r\n\tz-index: 25;\r\n\tborder-color: transparent;\r\n\twidth: 97px;\r\n\theight: auto;\r\n\tposition: fixed;\r\n\tright: 0;\r\n\tbackground-color: rgba(16, 58, 113, .9);\r\n\tborder: 2px solid #fec52e;
291\r\n\tborder-right: none;\r\n\tborder-radius: 17px 0 0 17px;\r\n\tline-height: 1.1;\r\n\tfont-size: 15px;\r\n\tpadding: 10px 3px 5px 13px;\r\n\tz-index: 26;\r\n\tbottom: 120px\r\n}\r\n\r\n.chat-icon svg {\r\n\tmargin: auto;\r\n width: 30px;\r\n height: 30px;\r\n}\r\n\r\n.chat-icon div img {\r\n\twidth: 30px\r\n}\r\n\r\n.chat-icon div p {\r\n\tmargin: 0 0 3px 7px;\r\n\tline-height: 17px\r\n}\r\n\r\n.chat-icon span {\r\n\tborder-left: 1px solid #fec52e;\r\n\tmargin-left: 15px;\r\n\theight: 50px;\r\n\tdisplay: none;\r\n\tmargin-right: 10px\r\n}\r\n\r\n.chat-icon .helpText {\r\n\tdisplay: none;\r\n\ttext-align: left\r\n}\r\n\r\n.chat-icon .helpText img {\r\n\tmargin: 8px 6px;\r\n\theight: 20px\r\n}\r\n\r\n.chat-icon:focus {\r\n\toutline: 0;\r\n\tbox-shadow: 0 0 0 .25rem rgb(49 132 253 \/ 50%)\r\n}\r\n"},"modal":{"description":"By clicking \u0027Accept\u0027, you will enable functional cookies that are necessary for the chatbot functionality on this platform. These cookies can be reviewed \u003Ca href=\u0022javascript:OneTrust.ToggleInfoDisplay();\u0022\u003Ehere\u003C\/a\u003E and adjusted at any time by clicking the shield above. Want to know more? View our \u003Ca target=\u0022_blank\u0022 href=\u0022https:\/\/www.otsuka-us.com\/privacy-policy\u0022\u003EPrivacy Notice\u003C\/a\u003E.","consent_label":"Accept","morelink_label":"Cookie Settings","morelink_url":"javascript:OneTrust.ToggleInfoDisplay();"}}},"otsuka_sfmc_registration":{"ceid":"sfmc_interaction_details[media_campaign_i_d]","CEID":"sfmc_interaction_details[media_campaign_i_d]"},"jynarque_hcc_2021":{"menu_behavior":"Sticky"},"user":{"uid":0,"permissionsHash":"59dbf4cc59884d330624630f14edc2551ab0b788421a6596fabf2e0fa445d8c3"}}</script>
vendor: 1 bytes, line 291
291
292<script src="core/assets/vendor/jquery/jquery.min.js"></script>
vendor: 1 bytes, line 292
292
293<script src="core/assets/vendor/once/once.min.js"></script>
vendor: 1 bytes, line 293
293
294<script src="core/misc/drupalSettingsLoader.js"></script>
vendor: 1 bytes, line 294
294
295<script src="core/misc/drupal.js"></script>
vendor: 1 bytes, line 295
295
296<script src="core/misc/drupal.init.js"></script>
vendor: 1 bytes, line 296
296
297<script src="core/assets/vendor/jquery.ui/ui/version-min.js"></script>
vendor: 1 bytes, line 297
297
298<script src="core/assets/vendor/jquery.ui/ui/data-min.js"></script>
vendor: 1 bytes, line 298
298
299<script src="core/assets/vendor/jquery.ui/ui/disable-selection-min.js"></script>
vendor: 1 bytes, line 299
299
300<script src="core/assets/vendor/jquery.ui/ui/jquery-patch-min.js"></script>
vendor: 1 bytes, line 300
300
301<script src="core/assets/vendor/jquery.ui/ui/scroll-parent-min.js"></script>
vendor: 1 bytes, line 301
301
302<script src="core/assets/vendor/jquery.ui/ui/unique-id-min.js"></script>
vendor: 1 bytes, line 302
302
303<script src="core/assets/vendor/jquery.ui/ui/focusable-min.js"></script>
vendor: 1 bytes, line 303
303
304<script src="core/assets/vendor/jquery.ui/ui/keycode-min.js"></script>
vendor: 1 bytes, line 304
304
305<script src="core/assets/vendor/jquery.ui/ui/plugin-min.js"></script>
vendor: 1 bytes, line 305
305
306<script src="core/assets/vendor/jquery.ui/ui/widget-min.js"></script>
vendor: 1 bytes, line 306
306
307<script src="core/assets/vendor/jquery.ui/ui/labels-min.js"></script>
vendor: 1 bytes, line 307
307
308<script src="core/assets/vendor/jquery.ui/ui/widgets/controlgroup-min.js"></script>
vendor: 1 bytes, line 308
308
309<script src="core/assets/vendor/jquery.ui/ui/form-reset-mixin-min.js"></script>
vendor: 1 bytes, line 309
309
310<script src="core/assets/vendor/jquery.ui/ui/widgets/mouse-min.js"></script>
vendor: 1 bytes, line 310
310
311<script src="core/assets/vendor/jquery.ui/ui/widgets/checkboxradio-min.js"></script>
vendor: 1 bytes, line 311
311
312<script src="core/assets/vendor/jquery.ui/ui/widgets/draggable-min.js"></script>
vendor: 1 bytes, line 312
312
313<script src="core/assets/vendor/jquery.ui/ui/widgets/resizable-min.js"></script>
vendor: 1 bytes, line 313
313
314<script src="core/assets/vendor/jquery.ui/ui/widgets/button-min.js"></script>
vendor: 1 bytes, line 314
314
315<script src="core/assets/vendor/jquery.ui/ui/widgets/dialog-min.js"></script>
vendor: 1 bytes, line 315
315
316<script src="core/assets/vendor/tabbable/index.umd.min.js"></script>
vendor: 1 bytes, line 316
316
317<script src="core/assets/vendor/tua-body-scroll-lock/tua-bsl.umd.min.js"></script>
vendor: 1 bytes, line 317
317
318<script src="modules/contrib/adobe_launch/js/adobe_launch_dtm_init.js"></script>
vendor: 1 bytes, line 318
318
319<script src="core/misc/debounce.js"></script>
vendor: 1 bytes, line 319
319
320<script src="core/misc/displace.js"></script>
vendor: 1 bytes, line 320
320
321<script src="core/misc/jquery.tabbable.shim.js"></script>
vendor: 1 bytes, line 321
321
322<script src="core/misc/position.js"></script>
vendor: 1 bytes, line 322
322
323<script src="core/misc/dialog/dialog-deprecation.js"></script>
vendor: 1 bytes, line 323
323
324<script src="core/misc/dialog/dialog.js"></script>
vendor: 1 bytes, line 324
324
325<script src="core/misc/dialog/dialog.position.js"></script>
vendor: 1 bytes, line 325
325
326<script src="core/misc/dialog/dialog.jquery-ui.js"></script>
vendor: 1 bytes, line 326
326
327<script src="core/modules/ckeditor5/js/ckeditor5.dialog.fix.js"></script>
vendor: 1 bytes, line 327
327
328<script src="modules/contrib/google_tag/js/gtag.js"></script>
vendor: 1 bytes, line 328
328
329<script src="core/misc/announce.js"></script>
vendor: 1 bytes, line 329
329
330<script src="modules/contrib/google_tag/js/gtm.js"></script>
vendor: 1 bytes, line 330
330
331<script src="core/misc/tabbingmanager.js"></script>
vendor: 1 bytes, line 331
331
332<script src="modules/custom/otsuka_privacy_compliant_media/js/otsuka_pcm_api.js"></script>
332 333 334 </head> 335 <body class="isi-enabled isi-drawer-enabled windows path-node node--type-landing-page"> 336 <a href="#main-content" class="visually-hidden focusable skip-link" tabindex="0"> 337 Skip to main content 338 </a> 339 <div class="accessible-overlay"></div>
vendor: 72 bytes, lines 339-340
339 340 <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=
340GTM-K4DRM2S
vendor: 108 bytes, lines 340-343
340" 341 height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> 342 343
343<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> 344 345 346 <div class="page-container" id="page-container"> 347 348 349 <header id="section-header" role="banner" class="header"> 350 <div id="header-middle" class="region--header-middle"> 351 <div class="container"> 352 <div class="region region-header-middle clearfix"> 353 <div id="block-jynarque-hcc-2021-fullpiheadertextblock" class="block-content-full-pi-header-text-block block-content-basic block block-block-content block-block-content23d37308-25c8-4a91-ba26-3b95fc1f0946 block-full-pi-header-text-block"> 354 355 356 <div class="content"> 357 358 359 360 361 362 363 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 364 <div class="field--item"><p><a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" target="_blank">FULL PRESCRIBING INFORMATION, including <strong>BOXED WARNING</strong></a></p> 365</div> 366 </div> 367 368 369 </div> 370 </div> 371<nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-headertopmenu-2-menu" id="block-jynarque-hcc-2021-headertopmenu-2"> 372 373 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-headertopmenu-2-menu">header top menu</h2> 374 375 376 377 <ul data-block="block-jynarque-hcc-2021-headertopmenu-2" data-test="top-menu" class="menu menu-header-top-menu nav"> 378 <li class="menu-item menu-item-1 nav-item"> 379 <a href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" target="_blank" class="external-link-popup-disabled">Medication Guide</a> 380 </li> 381 <li class="menu-item menu-item-2 nav-item"> 382 <a href="https://www.tolvaptanadpkdsharedrems.com/" target="_blank">REMS Program</a> 383 </li> 384 <li class="menu-item menu-item-3 nav-item"> 385 <a href="https://www.jynarquehcp.com/" target="_blank">HCP Site</a> 386 </li> 387 </ul> 388 389 390 391 </nav> 392<div id="block-jynarque-hcc-2021-copaysupportbutton" class="block-content-copay-support-button block-content-basic block block-block-content block-block-content8154085a-59d4-4744-8c49-bddc4f329f7f block-copay-support-button"> 393 394 395 <div class="content"> 396 397 398 399 400 401 402 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 403 <div class="field--item"><p><a href="copay-assistance.html"><span>Copay Assistance</span><span>Support</span></a></p></div> 404 </div> 405 406 407 </div> 408 </div> 409 410 </div> 411 412 </div> 413 </div> 414 <div id="header-bottom" class="region--header-bottom"> 415 <div class="container"> 416 <div class="region region-header-bottom clearfix"> 417 <div id="block-jynarque-hcc-2021-sitebranding" class="block block-system block-system-branding-block"> 418 419 420 <a href="index.html" rel="home" data-test='navbar-logo' data-analytics-name="JYNARQUE® Logo"> 421 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/jynarque-logo.svg" alt="JYNARQUE®, Logo" /> 422 </a> 423 424</div> 425<div id="block-copaysupportbutton" class="block-content-copay-support-button block-content-basic block block-block-content block-block-content8154085a-59d4-4744-8c49-bddc4f329f7f block-copay-support-button"> 426 427 428 <div class="content"> 429 430 431 432 433 434 435 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 436 <div class="field--item"><p><a href="copay-assistance.html"><span>Copay Assistance</span><span>Support</span></a></p></div> 437 </div> 438 439 440 </div> 441 </div> 442<nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-mainnavigation-menu" id="block-jynarque-hcc-2021-mainnavigation"> 443 444 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-mainnavigation-menu">Main navigation</h2> 445 446 447 448 <ul data-block="block-jynarque-hcc-2021-mainnavigation" data-test="main-menu" class="menu menu-main nav"> 449 <li class="menu-item menu-item-1 menu-item--expanded menu-item--active-trail nav
449-item"> 450 <a href="#"><span>About JYNARQUE</span></a> 451 <ul class="menu nav"> 452 <li class="menu-item menu-item-1 menu-item--active-trail nav-item"> 453 <a href="understanding-adpkd-progression.html" data-drupal-link-system-path="node/37481" class="is-active" aria-current="page">Understanding ADPKD & Progression</a> 454 </li> 455 <li class="menu-item menu-item-2 nav-item"> 456 <a href="why-jynarque.html" data-drupal-link-system-path="node/6">Why JYNARQUE?</a> 457 </li> 458 <li class="menu-item menu-item-3 nav-item"> 459 <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a> 460 </li> 461 <li class="menu-item menu-item-4 nav-item"> 462 <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a> 463 </li> 464 <li class="menu-item menu-item-5 nav-item"> 465 <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a> 466 </li> 467 </ul> 468 469 </li> 470 <li class="menu-item menu-item-2 menu-item--expanded nav-item"> 471 <a href="#"><span>Getting Started</span></a> 472 <ul class="menu nav"> 473 <li class="menu-item menu-item-1 nav-item"> 474 <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a> 475 </li> 476 <li class="menu-item menu-item-2 nav-item"> 477 <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a> 478 </li> 479 <li class="menu-item menu-item-3 nav-item"> 480 <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a> 481 </li> 482 <li class="menu-item menu-item-4 nav-item"> 483 <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a> 484 </li> 485 </ul> 486 487 </li> 488 <li class="menu-item menu-item-3 nav-item"> 489 <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a> 490 </li> 491 <li class="menu-item menu-item-4 menu-item--expanded nav-item"> 492 <a href="#"><span>Resources</span></a> 493 <ul class="menu nav"> 494 <li class="menu-item menu-item-1 nav-item"> 495 <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a> 496 </li> 497 <li class="menu-item menu-item-2 nav-item"> 498 <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a> 499 </li> 500 </ul> 501 502 </li> 503 </ul> 504 505 506 507 </nav> 508 509 <a href="#" class="mobile-menu-open-btn" data-test='mobile-menu-toggle'> 510 <span>Mobile menu</span> 511 </a> 512 <a href="#" class="mobile-menu-close-btn"> 513 <span>Mobile menu</span> 514 </a> 515 </div> 516 517 </div> 518 </div> 519 </header> 520 521 <div id="mobile-menu" class="region--mobile-menu" data-analytics-position="header"> 522 <div class="container"> 523 <div class="region region-mobile-menu clearfix"> 524 <nav role="navigation" aria-labelledby="block-mainnavigation-menu" id="block-mainnavigation"> 525 526 <h2 class="visually-hidden" id="block-mainnavigation-menu">Main navigation</h2> 527 528 529 530 <ul data-block="block-mainnavigation" data-test="main-menu" class="menu menu-main nav"> 531 <li class="menu-item menu-item-1 menu-item--expanded menu-item--active-trail nav
531-item"> 532 <a href="#"><span>About JYNARQUE</span></a> 533 <ul class="menu nav"> 534 <li class="menu-item menu-item-1 menu-item--active-trail nav-item"> 535 <a href="understanding-adpkd-progression.html" data-drupal-link-system-path="node/37481" class="is-active" aria-current="page">Understanding ADPKD & Progression</a> 536 </li> 537 <li class="menu-item menu-item-2 nav-item"> 538 <a href="why-jynarque.html" data-drupal-link-system-path="node/6">Why JYNARQUE?</a> 539 </li> 540 <li class="menu-item menu-item-3 nav-item"> 541 <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a> 542 </li> 543 <li class="menu-item menu-item-4 nav-item"> 544 <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a> 545 </li> 546 <li class="menu-item menu-item-5 nav-item"> 547 <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a> 548 </li> 549 </ul> 550 551 </li> 552 <li class="menu-item menu-item-2 menu-item--expanded nav-item"> 553 <a href="#"><span>Getting Started</span></a> 554 <ul class="menu nav"> 555 <li class="menu-item menu-item-1 nav-item"> 556 <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a> 557 </li> 558 <li class="menu-item menu-item-2 nav-item"> 559 <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a> 560 </li> 561 <li class="menu-item menu-item-3 nav-item"> 562 <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a> 563 </li> 564 <li class="menu-item menu-item-4 nav-item"> 565 <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a> 566 </li> 567 </ul> 568 569 </li> 570 <li class="menu-item menu-item-3 nav-item"> 571 <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a> 572 </li> 573 <li class="menu-item menu-item-4 menu-item--expanded nav-item"> 574 <a href="#"><span>Resources</span></a> 575 <ul class="menu nav"> 576 <li class="menu-item menu-item-1 nav-item"> 577 <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a> 578 </li> 579 <li class="menu-item menu-item-2 nav-item"> 580 <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a> 581 </li> 582 </ul> 583 584 </li> 585 </ul> 586 587 588 589 </nav> 590 591 </div> 592 593 </div> 594 </div> 595 <section aria-label="Header Information"> 596 <div id="header-info" class="region--header-info"> 597 <div class="container"> 598 <div class="region region-header-info clearfix"> 599 <div id="block-jynarque-hcc-2021-headertextdescription" class="block-content-header-text-description block-content-basic block block-block-content block-block-content855941ea-329b-4a19-bc10-2bd1df83da5c block-header-text-description"> 600 601 602 <div class="content"> 603 604 605 606 607 608 609 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 610 <div class="field--item"><p>Proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD</p></div> 611 </div> 612 613 614 </div> 615 </div> 616 617 </div> 618 619 </div> 620 </div> 621 </section> 622 623 624 <main role="main" class="main-content" id="main-content"> 625 <div class="container"> 626 <div class="region region-highlighted clearfix"> 627 <div data-drupal-messages-fallback class="hidden"></div> 628 629 </div> 630 631 </div> 632 <div class="no-sidebar"> 633 <div class="region region-content clearfix">
634 <div id="block-jynarque-hcc-2021-content" class="block block-system block-system-main-block"> 635 636 637 <div class="content"> 638 639 640<article data-history-node-id="37481" about="/understanding-adpkd-progression" class="node node-type-landing-page node--promoted node-view-mode-full"> 641 642 643 644 645 646 <div class="hero-section"> 647 648 649 </div> 650 651 <div class="node-content"> 652 653 654 655 656<div class="field field--name-field-formatted-title field--type-text-long field--label-hidden container" data-test='paragraph'> 657 <div class="field--item"> 658 <h1 class="title-inline-line"><span>Understanding</span> <span><strong>ADPKD & PROGRESSION</strong></span></h1> 659 660 </div> 661 </div> 662 663 664 665 666 667 668 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 669 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4721" data-test='paragraph'> 670 671 672 673 674 675 676 677 678 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 679 <div class="field--item"> <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-4716" > 680 681 682 683 684 685 686 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 687 <div class="field--item"><h2 class="pt-1 mb-0 mb-md-4">Rapidly progressing ADPKD vs being at risk for rapidly progressing ADPKD</h2></div> 688 </div> 689 690 691 </div> 692</div> 693 </div> 694 695 696 </div> 697</div> 698 <div class="field--item"> 699 <div class="clearfix understanding-container" id="paragraph-4726" data-test='paragraph'> 700 <div class="understanding-flex"> 701 <article class="understanding understanding--one"> 702 <div class="understanding__background"> 703 <div> 704 <figure class="understanding__figure"> 705 <img src="sites/g/files/qhldwo12166/files/2025-04/dotted-kidney-yellow-icon.svg" alt="" > 706 </figure> 707 <h3 class="understanding__heading">The truth about autosomal dominant polycystic kidney disease (ADPKD) progression is that it looks different for everyoneâeven within the same family</h3> 708 <div class="understanding__content"> 709 <ul><li>A parent with ADPKD has a 50% chance of passing it on to each child</li><li>It is important to know that ADPKD disease progression and symptoms vary amongst patients</li></ul> 710 </div> 711 </div> 712 </div> 713 </article> 714 <article class="understanding understanding--two"> 715 <div class="understanding__background"> 716 <div> 717 <figure class="understanding__figure"> 718 <img src="sites/g/files/qhldwo12166/files/2025-04/kidney-volume-blue-icon.svg" alt="" > 719 </figure> 720 <h3 class="understanding__heading">With rapidly progressing ADPKD, kidney function worsens and cysts grow more quickly, leading to early kidney failure</h3> 721 <div class="understanding__content"> 722 <ul><li>According to the Mayo Clinic ADPKD study, out of 538 patients, ~2/3 of this group were at risk for rapid progression</li></ul> 723 </div> 724 </div> 725 </div> 726 </article> 727 </div> 728 </div> 729</div> 730 <div class="field--item"> <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default gs-animation-paragraph" id="paragraph-5651" data-test='paragraph'> 731 732 733 734 735 736 <h2>Why does kidney size matter?</h2> 737 738 739 740 741 742 743 744 745 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 746 <div class="field--item"> <div class="clearfix paragraph paragraph--type--block paragraph--view-mode--default" id="paragraph-5646" > 747 748 749 750 751 752 753 <div class="field field--name-field-block field--type-entity-reference field--label-hidden"> 754 <div class="field--item"><div class="gs-animation-wrapper"> 755 <div class="gs-animation-wrapper__animation"> 756 <div id="desContainer_C2" class="des-container"> 757 <div id="diseaseEducationSlider_C2" class="disease-education-sli
757der"> 758 <div class="scene-wrapper" style="opacity: 0"> 759 <div class="scene"> 760 761 <div id="desPic1_C2" class="des-pic"> 762 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney1.png" alt="Kidney 1"> 763 </div> 764 <div id="desPic2_C2" class="des-pic"> 765 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney2.png" alt="Kidney 2"> 766 </div> 767 <div id="desPic3_C2" class="des-pic"> 768 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney3.png" alt="Kidney 3"> 769 </div> 770 <div id="desPic4_C2" class="des-pic"> 771 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney4.png" alt="Kidney 4"> 772 </div> 773 774 <div class="des-text-under-line des-text-under-line-first"> 775 <p>Kidney function (eGFR)</p> 776 </div> 777 <div class="des-text-under-line des-text-under-line-second"> 778 <p>Kidney size <br />(total kidney <br />volume)</p> 779 </div> 780 781 782 783 <div id="desLineWrapper1_C2" class="des-line-wrapper"> 784 <svg class="des-top-arrow-dot" width="11" height="11" viewB
784ox="0 0 11 11" fill="none" xmlns="http://www.w3.org/2000/svg"> 785 <mask id="mask0_2003_504" style="mask-type:luminance" maskUnits="userSpaceOnUse" x="0" y="0" width="11" height="11"> 786 <path d="M0.659912 5.20875C0.659912 7.96875 2.88991 10.1988 5.64991 10.1988C8.40991 10.1988 10.6399 7.96875 10.6399 5.20875C10.6399 2.44875 8.40991 0.21875 5.64991 0.21875C2.88991 0.21875 0.659912 2.44875 0.659912 5.20875Z" fill="white"/> 787 </mask> 788 <g mask="url(#mask0_2003_504)"> 789 <path d="M10.6399 0.21875H0.659912V10.1988H10.6399V0.21875Z" fill="url(#paint0_linear_2003_504)"/> 790 </g> 791 <defs> 792 <linearGradient id="paint0_linear_2003_504" x1="0.0799121" y1="3.12776" x2="393.067" y2="3.12776" gradientUnits="userSpaceOnUse"> 793 <stop stop-color="#4F9342"/> 794 <stop offset="0.02" stop-color="#4F9342"/> 795 <stop offset="1" stop-color="#FFC62F"/> 796 </linearGradient> 797 </defs> 798 </svg> 799 <svg id="desLine1_C2" class="des-line" width="796" height="530" viewBox="0 0 796 530" fill="none" xmlns="http://www.w3.org/2000/svg"> 800 <path id="desLine1Template_C2" class="des-line--template" d="M2 173.5L448.174 173.5C476.542 173.5 503.085 187.489 519.119 210.891L722 507" stroke="#444" stroke-width="1"/> 801 <path id="desLine1Path_C2" class="des-line--path" d="M2 173.5L448.174 173.5C476.542 173.5 503.085 187.489 519.119 210.891L722 507" stroke="url(#paint0_linear_C2)" stroke-width="2"/> 802 <defs> 803 <linearGradient id="paint0_linear_C2" x1="12.0006" y1="119.499" x2="943.501" y2="637.499" gradientUnits="userSpaceOnUse"> 804 <stop offset="0.213542" stop-color="#489537"/> 805 <stop offset="0.432292" stop-color="#FAC031"/> 806 <stop offset="0.692708" stop-color="#D12229"/> 807 </linearGradient> 808 </defs> 809 <g id="desLineArrow1_C2" class="des-line--arrow"> 810 <svg width="12" height="22" viewBox="0 0 12 22" fill="none" xmlns="http://www.w3.org/2000/svg"> 811 <path d="M0.579956 21.4775L11.62 11.2075L0.579956 0.9375V21.4775Z" fill="white"/> 812 </svg> 813 </g> 814 </svg> 815 </div> 816 817 <div id="desLineWrapper2_C2" class="des-line-wrapper"> 818 <svg class="des-bottom-arrow-dot" width="11" height="11" viewB
818ox="0 0 11 11" fill="none" xmlns="http://www.w3.org/2000/svg"> 819 <mask id="mask0_2003_504" style="mask-type:luminance" maskUnits="userSpaceOnUse" x="0" y="0" width="11" height="11"> 820 <path d="M0.659912 5.20875C0.659912 7.96875 2.88991 10.1988 5.64991 10.1988C8.40991 10.1988 10.6399 7.96875 10.6399 5.20875C10.6399 2.44875 8.40991 0.21875 5.64991 0.21875C2.88991 0.21875 0.659912 2.44875 0.659912 5.20875Z" fill="#0D5362"/> 821 </mask> 822 <g mask="url(#mask0_2003_504)"> 823 <path d="M10.6399 0.21875H0.659912V10.1988H10.6399V0.21875Z" fill="#0D5362"/> 824 </g> 825 </svg> 826 <svg id="desLine2_C2" class="des-line" width="792" height="237" viewBox="0 0 792 237" fill="none" xmlns="http://www.w3.org/2000/svg"> 827 <path id="desLine2Template_C2" class="des-line--template" d="M3.49998 210.5C257 187 553.5 99.5 782 2.50001" stroke="#444" stroke-width="1"/> 828 <path id="desLine2Path_C2" class="des-line--path" d="M3.49998 210.5C257 187 553.5 99.5 782 2.50001" stroke="#0D5362" stroke-width="2"/> 829 <g id="desLineArrow2_C2" class="des-line--arrow"> 830 <svg width="12" height="22" viewBox="0 0 12 22" fill="none" xmlns="http://www.w3.org/2000/svg"> 831 <path d="M0.579956 21.4775L11.62 11.2075L0.579956 0.9375V21.4775Z" fill="#0D5362"/> 832 </svg> 833 </g> 834 </svg> 835 </div> 836 837 </div> 838 839 <div class="timeline-wrapper"> 840 <form> 841 <label for="timeRange" class="hidden">Time Range</label> 842 <input type="range" min="0" max="1" step="0.01" value="0" id="timeRange" class="timeline" /> 843 </form> 844 </div> 845 846 <div class="timeline-text">Time</div> 847 </div> 848 </div> 849 </div> 850 <div class="des-bottom-text">Slide the yellow dot above to see the growth of kidney size over time</div> 851 </div> 852 <div class="gs-animation-wrapper__text"> 853 <p>In ADPKD, kidney growth caused by cysts often happens before your kidney function decline appears. Kidney function, measured by estimated glomerular filtration rate (eGFR), may remain stable while your kidneys continue to grow and can mask the irreversible damage. Because of this, kidney size, or total kidney volume (TKV), is the best predictor of ADPKD progression.</p> 854 <p>Your nephrologist can use an ultrasound, magnetic resonance imaging (MRI), or computed tomography (CT) to measure your kidney size and determine your risk of ADPKD progression.</p> 855 </div> 856</div> 857<div class="gs-animation-button-wrapper"> 858 <button type="button" data-toggle="modal" data-target="#predictProgression"> 859 Learn how kidney size is used to predict ADPKD progression 860 </button> 861</div> 862 863<!-- Modal --> 864<div class="modal fade predict-progression" id="predictProgression" tabindex="-1" role="dialog" aria-labelledby="predictProgressionModalLabel" aria-hidden="true"> 865 <div class="modal-dialog content-dialog" role="document" data-test='modal'> 866 <div class="modal-content"> 867 <button data-test='modal-close' 868 type="button" 869 class="close" 870 data-dismiss="modal" 871 aria-label="Close" 872 data-analytics-name="Close" 873 ></button> 874 <div class="modal-body" data-test='modal-body'> 875 <h2 data-test='modal-title'>How is kidney size used to predict ADPKD progression?</h2> 876 <p>Your nephrologist will take your total kidney volume (TKV) and adjust it based on your height to determine your risk of disease progression. This measurement is called a height-adjusted total kidney volume, or hTKV.</p> 877 <p>For example, two people may have the same size kidneys, but the shorter person may be at greater risk for rapid disease progression. Or, two people may have the same size kidneys and same height, but if one is younger, that person may be at risk for faster disease progression.</p> 878 <div class="predict-progression__patients"> 879 <img class="d-md-none" alt="Patient 1, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-1.svg" /> 880 <img class="d-md-none" alt="Patient 2, 70 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-2.svg" /> 881 <img class="d-md-none" alt="Patient 3, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-3.svg" /> 882 <img class="d-none d-md-block" alt="Patient 1, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-1-desktop.svg" /> 883 <img class="d-none d-md-block" alt="Patient 2, 70 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-2-desktop.svg" /> 884 <img class="d-none d-md-block" alt="Patient 3, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-3-desktop.svg" /> 885 </div> 886 <p>After determining your hTKV, your nephrologist may use your age and hTKV on a tool called the Mayo Imaging Classification chart to help predict your rate of disease progression.</p> 887 <img class="d-md-none" alt="Risk of Rapid Progression, Graph" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/TKV-Chart-Mobile.svg" /> 888 <img class="d-none d-md-block" alt="Risk of Rapid Progression, Graph" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/risk-of-rapid-progression-graph.svg" /> 889 </div> 890 </div> 891 </div> 892</div> 893</div> 894 </div> 895 896 897 </div> 898</div> 899 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option-2024 paragraph--view-mode--default" id="paragraph-5671" > 900 <div class="container"> 901 <div class="sto"> 902 903 <div class="sto-image"></div> 904 905 <div class="sto-content"> 906 907 </div> 908 909 </div> 910 </div> 911 </div> 912</div> 913 </div> 914 915 916 </div> 917</div> 918 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4746" data-test='paragraph'> 919 920 921 922 923 924 <h2>Assessing your ADPKD progression</h2> 925 926 927 928 929 930 931 932 933 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 934 <div class="field--item"> <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-5666" > 935 <div class="row"> 936 937 938 939 940 941 942 943 944 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 945 <div class="field--item"> <div class="col-12 clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-5656" > 946 947 948 949 950 951 952 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 953 <div class="field--item"><h3>Is your eGFR rapidly declining?</h3><h4>Your ADPKD could already be rapidly progressing.</h4><p>A person with ADPKD is considered to be already rapidly progressing when their eGFR (a test result that measures how well the kidneys work) declines quickly.</p><p>eGFR is declining quickly when it drops: ⥠3 mL/min/1.73 m<sup>2</sup> per year over a 3-5 year period.</p></div> 954 </div> 955 956 957 </div> 958</div> 959 </div> 960 961 962 </div> 963 </div> 964</div> 965 </div> 966 967 968 </div> 969</div> 970 <div class="field--item"> <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default icon-with-text-group" id="paragraph-4856" data-test='paragraph'> 971 <div class="container"> 972 <div class="row"> 973 974 975 976 977 978 979 980 981 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 982 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-4776" > 983 984 985 986 987 988 989 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 990 <div class="field--item"><h2 class="mb-3 mb-md-3">Is your eGFR stable?</h2><p class="mb-4 ff-lato-500-mobile">You could still be at risk of rapidly progressing ADPKD.</p><p class="ff-lato-500-mobile">There are a number of factors that may put someone already living with ADPKD at <strong>risk of rapid ADPKD progression</strong>. These may include:</p></div> 991 </div> 992 993 994 </div> 995</div> 996 <div class="field--item"> <div class="container simple-text-options-wrapper columns 2-columns two-columns clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4851" > 997 998 999 1000 1001 1002 1003 1004 1005 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1006 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4786" > 1007 1008 1009 1010 1011 1012 1013 1014 1015 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1016 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4781" > 1017 <div class="container"> 1018 <div class="d-block d-lg-none d-xl-none"> 1019 1020 </div> 1021 <div class="sto"> 1022 <div class="sto-image"> 1023 1024 1025 1026 1027 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/kidney-volume-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1028 1029 1030 </div> 1031 <div class="sto-content"> 1032 <div class="d-none d-lg-block d-xl-block"> 1033 1034 </div> 1035 1036 1037 1038 1039 1040 1041 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1042 <div class="field--item"><p class="ff-lato-500-mobile">Kidneys that are bigger than normal for a person's age with ADPKD (high total kidney volume)</p></div> 1043 </div> 1044 1045 1046 </div> 1047 </div> 1048 </div> 1049 </div> 1050</div> 1051 </div> 1052 1053 1054 </div> 1055</div> 1056 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4796" > 1057 1058 1059 1060 1061 1062 1063 1064 1065 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1066 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4791" > 1067 <div class="container"> 1068 <div class="d-block d-lg-none d-xl-none"> 1069 1070 </div> 1071 <div class="sto"> 1072 <div class="sto-image"> 1073 1074 1075 1076 1077 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/genetic-mutation-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1078 1079 1080 </div> 1081 <div class="sto-content"> 1082 <div class="d-none d-lg-block d-xl-block"> 1083 1084 </div> 1085 1086 1087 1088 1089 1090 1091 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1092 <div class="field--item"><p class="ff-lato-500-mobile">Certain types of genetic mutations</p></div> 1093 </div> 1094 1095 1096 </div> 1097 </div> 1098 </div> 1099 </div> 1100</div> 1101 </div> 1102 1103 1104 </div> 1105</div> 1106 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4806" > 1107 1108 1109 1110 1111 1112 1113 1114 1115 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1116 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4801" > 1117 <div class="container"> 1118 <div class="d-block d-lg-none d-xl-none"> 1119 1120 </div> 1121 <div class="sto"> 1122 <div class="sto-image"> 1123 1124 1125 1126 1127 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/family-history-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1128 1129 1130 </div> 1131 <div class="sto-content"> 1132 <div class="d-none d-lg-block d-xl-block"> 1133 1134 </div> 1135 1136 1137 1138 1139 1140 1141 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1142 <div class="field--item"><p class="ff-lato-500-mobile">Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58</p></div> 1143 </div> 1144 1145 1146 </div> 1147 </div> 1148 </div> 1149 </div> 1150</div> 1151 </div> 1152 1153 1154 </div> 1155</div> 1156 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4816" > 1157 1158 1159 1160 1161 1162 1163 1164 1165 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1166 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4811" > 1167 <div class="container"> 1168 <div class="d-block d-lg-none d-xl-none"> 1169 1170 </div> 1171 <div class="sto"> 1172 <div class="sto-image"> 1173 1174 1175 1176 1177 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/high-blood-pressure-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1178 1179 1180 </div> 1181 <div class="sto-content"> 1182 <div class="d-none d-lg-block d-xl-block"> 1183 1184 </div> 1185 1186 1187 1188 1189 1190 1191 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1192 <div class="field--item"><p class="ff-lato-500-mobile">High blood pressure that started before the age of 35</p></div> 1193 </div> 1194 1195 1196 </div> 1197 </div> 1198 </div> 1199 </div> 1200</div> 1201 </div> 1202 1203 1204 </div> 1205</div> 1206 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4826" > 1207 1208 1209 1210 1211 1212 1213 1214 1215 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1216 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4821" > 1217 <div class="container"> 1218 <div class="
1218d-block d-lg-none d-xl-none"> 1219 1220 </div> 1221 <div class="sto"> 1222 <div class="sto-image"> 1223 1224 1225 1226 1227 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/symptoms-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1228 1229 1230 </div> 1231 <div class="sto-content"> 1232 <div class="d-none d-lg-block d-xl-block"> 1233 1234 </div> 1235 1236 1237 1238 1239 1240 1241 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1242 <div class="field--item"><p class="ff-lato-500-mobile">Blood in urine (hematuria), cyst infections, or flank pain related to cysts, before age 35</p></div> 1243 </div> 1244 1245 1246 </div> 1247 </div> 1248 </div> 1249 </div> 1250</div> 1251 </div> 1252 1253 1254 </div> 1255</div> 1256 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4836" > 1257 1258 1259 1260 1261 1262 1263 1264 1265 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1266 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4831" > 1267 <div class="container"> 1268 <div class="d-block d-lg-none d-xl-none"> 1269 1270 </div> 1271 <div class="sto"> 1272 <div class="sto-image"> 1273 1274 1275 1276 1277 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/weight-scale-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1278 1279 1280 </div> 1281 <div class="sto-content"> 1282 <div class="d-none d-lg-block d-xl-block"> 1283 1284 </div> 1285 1286 1287 1288 1289 1290 1291 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1292 <div class="field--item"><p class="ff-lato-500-mobile">Being overweight, with a body mass index â¥25 kg/m<sup>2</sup></p></div> 1293 </div> 1294 1295 1296 </div> 1297 </div> 1298 </div> 1299 </div> 1300</div> 1301 </div> 1302 1303 1304 </div> 1305</div> 1306 <div class="field--item"> <div class="simple-text-option type-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4846" > 1307 1308 1309 1310 1311 1312 1313 1314 1315 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1316 <div class="field--item"> <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4841" > 1317 <div class="container"> 1318 <div class="d-block d-lg-none d-xl-none"> 1319 1320 </div> 1321 <div class="sto"> 1322 <div class="sto-image"> 1323 1324 1325 1326 1327 <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/side-effects-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" /> 1328 1329 1330 </div> 1331 <div class="sto-content"> 1332 <div class="d-none d-lg-block d-xl-block"> 1333 1334 </div> 1335 1336 1337 1338 1339 1340 1341 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1342 <div class="field--item"><p class="ff-lato-500-mobile">Protein and albumin in urine (proteinuria and albuminuria)</p></div> 1343 </div> 1344 1345 1346 </div> 1347 </div> 1348 </div> 1349 </div> 1350</div> 1351 </div> 1352 1353 1354 </div> 1355</div> 1356 </div> 1357 1358 1359 </div> 1360</div> 1361 </div> 1362 1363 1364 </div> 1365 </div> 1366 </div> 1367</div> 1368 <div class="field--item"> 1369 1370 <div class="clearfix container" id="paragraph-4861" data-test='card'> 1371 <div class="border-box"> 1372 <h2 class="border-box__heading">Be Proactive</h2> 1373 1374 <div class="border-box__text"> 1375 <p class="mb-0 fw-900">
1375Wherever you are in your ADPKD journey, it's important to talk with your nephrologist to develop an appropriate treatment plan for your individual situation.</p><p class="fw-600 ff-lato-600-mobile">The sooner you start, the sooner you can help take control of your ADPKD and may start to experience the benefits of slowing down your disease progression. Don't wait, take the first step today. Make a plan to have a discussion about what you can do to help manage your ADPKD at your next appointment.</p> 1376 </div> 1377 </div> 1378 </div> 1379</div> 1380 <div class="field--item"> <div class="container paragraph-link-bg type-b link-paragraph button clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4876" data-test='paragraph'> 1381 1382 1383 1384 1385 1386 1387 1388 1389 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1390 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--link paragraph--view-mode--default" id="paragraph-4871" > 1391 1392 1393 1394 1395 1396 <h3 class="mb-md-4 pb-1">If you have any of these risk factors,</h3> 1397 1398 1399 1400 1401 1402 1403 <div class="field field--name-field-link field--type-link field--label-hidden"> 1404 <div class="field--item"><a href="is-jynarque-for-you.html">See if JYNARQUE is right for you</a></div> 1405 </div> 1406 1407 1408 </div> 1409</div> 1410 </div> 1411 1412 1413 </div> 1414</div> 1415 <div class="field--item"> <div class="link-paragraph line clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4891" data-test='paragraph'> 1416 1417 1418 1419 1420 1421 1422 1423 1424 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 1425 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--link paragraph--view-mode--default" id="paragraph-4886" > 1426 1427 1428 1429 1430 1431 1432 <div class="field field--name-field-link field--type-link field--label-hidden"> 1433 <div class="field--item"><a href="why-jynarque.html">Why JYNARQUE?</a></div> 1434 </div> 1435 1436 1437 </div> 1438</div> 1439 </div> 1440 1441 1442 </div> 1443</div> 1444 </div> 1445 1446 1447 </div> 1448 1449</article> 1450 1451 </div> 1452 </div> 1453 1454 </div> 1455 1456 </div> 1457 <div class="isi-page-wrapper"> 1458 <div class="container"> 1459 <div class="region region-isi clearfix"> 1460 1461 1462 1463 <a id="isi-top" name="isi-top"></a> 1464 <section id="inline-isi-wrapper" class="section isi-section" data-test="isi"> 1465 1466 <div class="isi isi-block"> 1467 <div class="isi-inline-title-wrap"><span class="isi-block-title">ISI Block Title 1468</span></div> 1469 1470 <div class="isi-inline-inner-wrap"><div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink
1470water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1â800â438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p> 1471</div> 1472 </div> 1473 1474 </section> 1475 1476 </div> 1477 1478 </div> 1479 </div> 1480 </main> 1481 1482 </div> 1483 1484 1485<footer id="section-footer" role="contentinfo"> 1486 <div id="footer"> 1487 <div class="container"> 1488 <div class="row"> 1489 <div class="col-12 col-lg-7 col-xl-8"> 1490 <div class="logo-footer"> 1491 <a href="https://www.otsuka-us.com/" target="_blank" data-test='navbar-branding' data-analytics-name="Otsuka Logo"> 1492 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/otsuka-logo.png" alt="Otsuka, Logo"> 1493 </a> 1494 </div> 1495 <div class="footer-inline-items"> <div class="region region-footer-1 clearfix"> 1496 <div id="block-otsukacopyright" class="block block-otsuka-prc-code block-otsuka-copyright"> 1497 1498 1499 <div class="content" data-test='copyright'> 1500 © 2026 Otsuka America Pharmaceutical, Inc. 1501 </div> 1502 </div> 1503<div id="block-footerinlinetext" class="block-content-footer-inline-text block-content-basic block block-block-content block-block-content7f8acdb7-b4f7-4e3a-b947-0371f92fc130 block-footer-inline-text"> 1504 1505 1506 <div class="content"> 1507 1508 1509 1510 1511 1512 1513 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 1514 <div class="field--item"><p>All rights reserved.</p></div> 1515 </div> 1516 1517 1518 </div> 1519 </div> 1520<div id="block-jynarque-hcc-2021-prcdate" class="block block-otsuka-prc-code block-prc-code-date"> 1521 1522 1523 <div class="content" data-test='prc-date'> 1524 May 2026 1525 </div> 1526 </div> 1527<div id="block-jynarque-hcc-2021-prccode" class="block block-otsuka-prc-code block-prc-code"> 1528 1529 1530 <div class="content" data-test='prc-code'> 1531 10US26EBC0002 1532 </div> 1533 </div> 1534 1535 </div> 1536</div> 1537 </div> 1538 <div class="col-12 col-lg-5 col-xl-4"> 1539 <div class="region region-footer-2 clearfix"> 1540 <nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-footer-menu" id="block-jynarque-hcc-2021-footer"> 1541 1542 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-footer-menu">Footer menu</h2> 1543 1544 1545 1546 <ul data-block="block-jynarque-hcc-2021-footer" data-test="footer-menu" class="menu menu-footer nav"> 1547 <li class="menu-item menu-item-1 nav-item">
1548 <a href="https://www.otsuka-us.com/oapi-privacy-policy" target="_blank">Privacy Policy</a> 1549 </li> 1550 <li class="menu-item menu-item-2 nav-item"> 1551 <a href="https://www.otsuka-us.com/terms-and-conditions" target="_blank">Terms of Use</a> 1552 </li> 1553 <li class="menu-item menu-item-3 nav-item"> 1554 <a href="site-map.html" data-drupal-link-system-path="sitemap">Site Map</a> 1555 </li> 1556 </ul> 1557 1558 1559 1560 </nav> 1561<nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-footerlogos-menu" id="block-jynarque-hcc-2021-footerlogos"> 1562 1563 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-footerlogos-menu">footer logos</h2> 1564 1565 1566 1567 <ul data-block="block-jynarque-hcc-2021-footerlogos" data-test="social-menu" class="menu menu-footer-logos nav"> 1568 <li class="menu-item menu-item-1 nav-item"> 1569 <a href="https://www.facebook.com/JYNARQUE" target="_blank" class="facebook">Facebook</a> 1570 </li> 1571 <li class="menu-item menu-item-2 nav-item"> 1572 <a href="https://www.instagram.com/jynarque_tolvaptan/" target="_blank" class="instagram">Instagram</a> 1573 </li> 1574 <li class="menu-item menu-item-3 nav-item"> 1575 <a href="https://x.com/JYNARQUE" class="twitter" target="_blank">X</a> 1576 </li> 1577 </ul> 1578 1579 1580 1581 </nav> 1582 1583 </div> 1584 1585 </div> 1586 </div> 1587 </div> 1588 </div> 1589 </footer> 1590 1591 1592 <div class="region region-visually-hidden clearfix"> 1593 <div id="block-covidpopupblock" class="block-content-covid-popup-block block-content-basic block block-block-content block-block-content70c8b744-13e7-4ccb-b65f-37b04443e87e block-covid-popup-block"> 1594 1595 1596 <div class="content"> 1597 1598 1599 1600 1601 1602 1603 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 1604 <div class="field--item"><h2>COVID-19 UPDATE</h2> 1605 1606<p>With the COVID-19 situation constantly developing, your health is our top priority. We hope that you and your families are staying safe and healthy during this unprecedented time.</p> 1607 1608<p>If you are currently taking JYNARQUE<sup>®</sup> (tolvaptan), we encourage you to stay in close contact with your healthcare professional team regarding regular appointments and treatment management plans.</p> 1609 1610<p>At this time, there is no expected impact on medication supply.</p> 1611 1612<p>During the current COVID-19 <span class="text-nowrap">pandemic, the JYNARQUE<sup>®</sup> (tolvaptan)</span> REMS Program requirements remain in effect, as the health of patients who use this product is our top priority. Ongoing blood monitoring required by the REMS Program is extremely important due to the potential risk of serious liver injury from treatment with JYNARQUE. For these lab requirements during COVID-19 pandemic, we are able to temporarily offer our Mobile Phlebotomy Collection Service at no-cost for all patients taking JYNARQUE who prefer to have the REMS required blood work collected at home.</p> 1613 1614<p>In helping patients who have lost a job or health insurance coverage due to the COVID-19 pandemic and to get through these challenging times, we have extended our Patient Support Program to provide âno-costâ access for patients in the U.S. who are taking JYNARQUE. Please call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a> for more information on both programs.</p> 1615 1616<p>For help accessing JYNARQUE, go to <a class="cta_exit" href="https://www.otsukapatientsupport.com/jynarque" target="_blank">www.otsukapatientsupport.com/jynarque</a> or call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a>. The nurses at Otsuka Patient Support can answer questions related to Product Accessibility, Reimbursement and connecting patients to local treatment sites in their community.</p> 1617 1618<p>Please read <a class="dummy external-link-popup-disabled" href="https://www.otsuka-u
1618s.com/media/static/JYNARQUE-PI.pdf" target="_blank">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="dummy external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" target="_blank">MEDICATION GUIDE</a>.</p> 1619 1620<p class="covid-footnote"><span class="covid-prc-1">September 2020</span><span class="covid-prc-2">10US20EBC0103</span></p> 1621</div> 1622 </div> 1623 1624 1625 </div> 1626 </div> 1627 1628 </div> 1629 1630 1631 </div> 1632 1633 1634 1635 1636 1637 1638 1639 1640 1641<section id="drawer-isi" class="isi-tray jsIsiContainer isi-drawer-collapsed" aria-label="ISI"> 1642 1643 <!--<div id="isi-drawer-wrapper" class="isi-drawer-collapsed">--> 1644 1645 <div class="isi-header"> 1646 <div class="isi-header-wrap"> 1647 <div class="drawer-title">IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan) 1648</div> 1649 <button class="isi-btn jsIsiMinimize" data-oapigtmcategory="Button Clicks" data-oapigtmaction="ISI" data-oapigtmlabel="More +"><span class="jsSwapText jsSwapTextExpand">More +</span><span class="jsSwapText jsSwapTextCollapse hide">Less -</span><span class="isi-btn-icon"></span></button> 1650 </div> 1651 </div> 1652 1653 <div class="isi isi-block isi-drawer-content isi-content-wrap"> 1654 <div class="jcf-scrollable jcf-container mCustomScrollbar"> 1655 <div class="isi-drawer-content-heading">ISI Block Title 1656</div> 1657 <div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink
1657water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1â800â438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p> 1658 1659 </div> 1660 </div> 1661 1662 <!--</div>--><!--/#isi-drawer-wrapper--> 1663 1664</section> 1665<style> 1666 1667 .isi-tray { 1668 left: 0%; 1669 width: 100%; 1670 } 1671 .isi-drawer-expanded { 1672 height: 100px; 1673 } 1674 .isi-drawer-collapsed { 1675 height: 40px; 1676 } 1677 1678 .isi-tray.isi-drawer-expanded .isi-content-wrap, 1679 .isi-tray.isi-drawer-expanded .isi-content-wrap>div { 1680 height: calc(50vh - 220px); 1681 } 1682 @media all and (min-width: 768px) { 1683 .isi-tray.isi-drawer-expanded .isi-content-wrap, 1684 .isi-tray.isi-drawer-expanded .isi-content-wrap>div { 1685 height: calc(50vh - 60px); 1686 } 1687 } 1688</style> 1689 1690 1691
1691<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/modernizr-custom.js"></script>
vendor: 1 bytes, line 1691
1691
1692<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/version-min.js"></script>
vendor: 1 bytes, line 1692
1692
1693<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/keycode-min.js"></script>
vendor: 1 bytes, line 1693
1693
1694<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/widgets/datepicker-min.js"></script>
vendor: 1 bytes, line 1694
1694
1695<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/focus.js"></script>
vendor: 1 bytes, line 1695
1695
1696<script src="modules/contrib/external_link_popup/js/dialog.js"></script>
vendor: 1 bytes, line 1696
1696
1697<script src="modules/contrib/extlink/extlink.js"></script>
vendor: 1 bytes, line 1697
1697
1698<script src="core/misc/progress.js"></script>
vendor: 1 bytes, line 1698
1698
1699<script src="core/assets/vendor/loadjs/loadjs.min.js"></script>
vendor: 1 bytes, line 1699
1699
1700<script src="core/misc/message.js"></script>
vendor: 1 bytes, line 1700
1700
1701<script src="core/misc/ajax.js"></script>
vendor: 1 bytes, line 1701
1701
1702<script src="modules/contrib/google_tag/js/gtag.ajax.js"></script>
vendor: 1 bytes, line 1702
1702
1703<script src="https://cdnjs.cloudflare.com/ajax/libs/gsap/3.5.1/gsap.min.js"></script>
vendor: 1 bytes, line 1703
1703
1704<script src="https://cdnjs.cloudflare.com/ajax/libs/gsap/3.5.1/MotionPathPlugin.min.js"></script>
vendor: 1 bytes, line 1704
1704
1705<script src="https://cdnjs.cloudflare.com/ajax/libs/rangeslider.js/2.3.3/rangeslider.min.js"></script>
vendor: 1 bytes, line 1705
1705
1706<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/src/js/block/gs-animation/CustomEase.min.js"></script>
vendor: 1 bytes, line 1706
1706
1707<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/src/js/block/gs-animation/DrawSVGPlugin.min.js"></script>
vendor: 1 bytes, line 1707
1707
1708<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.util.js"></script>
vendor: 1 bytes, line 1708
1708
1709<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.modal.js"></script>
vendor: 1 bytes, line 1709
1709
1710<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/block/gs-animation/gs-animation.settings.js"></script>
vendor: 1 bytes, line 1710
1710
1711<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/link_tagging.js"></script>
vendor: 1 bytes, line 1711
1711
1712<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form_ls_confirmation.js"></script>
vendor: 1 bytes, line 1712
1712
1713<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form.js"></script>
vendor: 1 bytes, line 1713
1713
1714<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form_modal.js"></script>
vendor: 1 bytes, line 1714
1714
1715<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/analytics/analytics-form.js"></script>
vendor: 1 bytes, line 1715
1715
1716<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/analytics/analytics-custom.js"></script>
vendor: 1 bytes, line 1716
1716
1717<script src="https://cdn.jsdelivr.net/npm/[email protected]/dist/loadjs.umd.min.js"></script>
vendor: 1 bytes, line 1717
1717
1718<script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script>
vendor: 1 bytes, line 1718
1718
1719<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.collapse.js"></script>
vendor: 1 bytes, line 1719
1719
1720<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.alert.js"></script>
vendor: 1 bytes, line 1720
1720
1721<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.button.js"></script>
vendor: 1 bytes, line 1721
1721
1722<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.dropdown.js"></script>
vendor: 1 bytes, line 1722
1722
1723<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/focus.advanced.js"></script>
vendor: 1 bytes, line 1723
1723
1724<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/otsuka-isi.js"></script>
vendor: 1 bytes, line 1724
1724
1725<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/interstitials.js"></script>
vendor: 1 bytes, line 1725
1725
1726<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/form-errors.js"></script>
vendor: 1 bytes, line 1726
1726
1727<script src="modules/custom/otsuka_facebook_api/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1727
1727
1728<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1728
1728
1729<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/src/js/opcm.js"></script>
vendor: 1 bytes, line 1729
1729
1730<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu-sticky.js"></script>
vendor: 1 bytes, line 1730
1730
1731<script src="modules/custom/pharma_isi/js/3rd-party/mCustomScrollbar/jquery.mCustomScrollbar.js"></script>
vendor: 1 bytes, line 1731
1731
1732<script src="modules/custom/pharma_isi/js/3rd-party/jquery.ba-throttle-debounce.min.js"></script>
vendor: 1 bytes, line 1732
1732
1733<script src="modules/custom/pharma_isi/js/pharma_isi_drawer.js"></script>
vendor: 1 bytes, line 1733
1733
1734<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/global.js"></script>
vendor: 1 bytes, line 1734
1734
1735<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu.main.js"></script>
vendor: 1 bytes, line 1735
1735
1736<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/node/node.landing-page.js"></script>
vendor: 1 bytes, line 1736
1736
1737<script src="modules/custom/otsuka_sfmc_registration/js/dist/otsuka_sfmc_preprocess.js"></script>
vendor: 1 bytes, line 1737
1737
1738<script src="modules/custom/pharma_isi/js/pharma_isi_inline.js"></script>
vendor: 1 bytes, line 1738
1738
1739<script src="modules/contrib/simple_popup_blocks/js/simple_popup_blocks.js"></script>
1739 1740 1741
1741<script type="module" src="https://static.cloudflareinsights.com/beacon.min.js/v4bc70e2c01a94c73b74392e4234840661791215815920" integrity="sha512-L0ha0OXavK/8okipN9F8BtP84dg9DUhPERbBXzwI6dgTA55d2+yweo3pn5CSFYs45/r8md2+xvUPtTdvTNRfjA==" data-cf-beacon='{"version":"2024.11.0","token":"bf71ae886def4acf823e0389d7b92acb","spa":2}' crossorigin="anonymous"></script>
1741 1742</body> 1743 1744 1745</html>
Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.