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136"headline": ["Understanding ADPKD &amp; Progression","The truth about autosomal dominant polycystic kidney disease (ADPKD) progression is that it looks different for everyone—even within the same family","With rapidly progressing ADPKD, kidney function worsens and cysts grow more quickly, leading to early kidney failure","Why does kidney size matter?","Assessing your ADPKD progression","Is your eGFR rapidly declining? Your ADPKD could already be rapidly progressing.","Is your eGFR stable? You could still be at risk of rapidly progressing ADPKD.","Be Proactive","How is kidney size used to predict ADPKD progression?"],
137"abstract": "Rapidly progressing ADPKD vs being at risk for rapidly progressing ADPKD",
138"description": ["A parent with ADPKD has a 50% chance of passing it on to each child","It is important to know that ADPKD disease progression and symptoms vary amongst patients","According to the Mayo Clinic ADPKD study, out of 538 patients, ~2/3 of this group were at risk for rapid progression","In ADPKD, kidney growth caused by cysts often happens before your kidney function decline appears. Kidney function, measured by estimated glomerular filtration rate (eGFR), may remain stable while your kidneys continue to grow and can mask the irreversible damage. Because of this, kidney size, or total kidney volume (TKV), is the best predictor of ADPKD progression.","Your nephrologist can use an ultrasound, magnetic resonance imaging (MRI), or computed tomography (CT) to measure your kidney size and determine your risk of ADPKD progression.","Your nephrologist will take your total kidney volume (TKV) and adjust it based on your height to determine your risk of disease progression. This measurement is called a height-adjusted total kidney volume, or hTKV.","For example, two people may have the same size kidneys, but the shorter person may be at greater risk for rapid disease progression. Or, two people may have the same size kidneys and same height, but if one is younger, that person may be at risk for faster disease progression.","After determining your hTKV, your nephrologist may use your age and hTKV on a tool called the Mayo Imaging Classification chart to help predict your rate of disease progression.","A person with ADPKD is considered to be rapidly progressing when their eGFR, a test result that measures how well the kidneys work, declines quickly relative to their age.","If your current eGFR falls on the chart below and you are experiencing an eGFR decline ≥ 3 mL/min/1.73 m2 per year over a period of 4 years or more, your ADPKD is rapidly progressing.","There are a number of factors that may put someone already living with ADPKD at risk of rapid ADPKD progression.","These may include: Kidneys that are bigger than normal for a person's age with ADPKD (high total kidney volume), Certain types of genetic mutations, Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58, High blood pressure that started before the age of 35, Blood in urine (hematuria), cyst infections, or flank pain related to cysts, before age 35, Being overweight, with a body mass index ≥25 kg/m2, Protein and albumin in urine (proteinuria and albuminuria).","Wherever you are in your ADPKD journey, it's important to talk with your nephrologist to develop an appropriate treatment plan for your individual situation.","The sooner you start, the sooner you can help take control of your ADPKD and may start to experience the benefits of slowing down your disease progression. Don't wait, take the first step today. Make a plan to have a discussion about what you can do to help manage your ADPKD at your next appointment."],
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163"description": ["A person with ADPKD is considered to be already rapidly progressing when their eGFR (a test result that measures how well the kidneys work) declines quickly. eGFR is declining quickly when it drops: ≥5 mL/min/1.73 m2 within 1 year OR ≥2.5 mL/min/1.73 m2/year over a 5-year period","There are a number of factors that may put someone already living with ADPKD at risk of rapid ADPKD progression. These may include: A high total kidney volume (kidneys that are larger than normal for a person with ADPKD), Blood in urine (hematuria), cyst infections, or flank pai related to cysts, before age 35, Certain types of genetic mutations, Being overweight, with a body mass index ≥25 kg/m2, Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58, Protein and albumin in urine (proteinuria and albuminuria), and High blood pressure that started before the age of 35"],
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592
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594  </div>
595  <section aria-label="Header Information">
596    <div id="header-info" class="region--header-info">
597      <div class="container">
598          <div class="region region-header-info clearfix">
599    <div id="block-jynarque-hcc-2021-headertextdescription" class="block-content-header-text-description block-content-basic block block-block-content block-block-content855941ea-329b-4a19-bc10-2bd1df83da5c block-header-text-description">
600  
601    
602      <div class="content">
603      
604
605
606
607
608  
609                        <div  class="field field--name-body field--type-text-with-summary field--label-hidden">
610                          <div class="field--item"><p>Proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD</p></div>
611                      </div>
612              
613  
614    </div>
615  </div>
616
617  </div>
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623
624    <main role="main" class="main-content" id="main-content">
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630
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635  
636    
637      <div class="content">
638      
639
640<article data-history-node-id="37481" about="/understanding-adpkd-progression" class="node node-type-landing-page node--promoted node-view-mode-full">
641
642  
643    
644
645  
646            <div class="hero-section">
647        
648        
649      </div>
650    
651    <div class="node-content">
652      
653
654
655
656<div  class="field field--name-field-formatted-title field--type-text-long field--label-hidden container" data-test='paragraph'>
657      <div class="field--item">
658      <h1 class="title-inline-line"><span>Understanding</span> <span><strong>ADPKD &amp; PROGRESSION</strong></span></h1>
659
660    </div>
661  </div>
662
663
664
665
666
667  
668                        <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
669                          <div class="field--item">  <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4721" data-test='paragraph'>
670                            
671
672
673
674
675
676  
677    
678                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
679                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-4716" >
680          
681
682
683
684
685  
686                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
687                          <div class="field--item"><h2 class="pt-1 mb-0 mb-md-4">Rapidly progressing ADPKD vs being at risk for rapidly progressing ADPKD</h2></div>
688                      </div>
689              
690  
691      </div>
692</div>
693                          </div>
694                  
695      
696                    </div>
697</div>
698                          <div class="field--item">  
699  <div class="clearfix understanding-container" id="paragraph-4726"  data-test='paragraph'>
700          <div class="understanding-flex">
701        <article class="understanding understanding--one">
702          <div class="understanding__background">
703            <div>
704                            <figure class="understanding__figure">
705                <img src="sites/g/files/qhldwo12166/files/2025-04/dotted-kidney-yellow-icon.svg" alt="" >
706              </figure>
707                                            <h3 class="understanding__heading">The truth about autosomal dominant polycystic kidney disease (ADPKD) progression is that it looks different for everyone—even within the same family</h3>
708                            <div class="understanding__content">
709                <ul><li>A parent with ADPKD has a 50% chance of passing it on to each child</li><li>It is important to know that ADPKD disease progression and symptoms vary amongst patients</li></ul>
710              </div>
711            </div>
712          </div>
713        </article>
714        <article class="understanding understanding--two">
715          <div class="understanding__background">
716            <div>
717                          <figure class="understanding__figure">
718                <img src="sites/g/files/qhldwo12166/files/2025-04/kidney-volume-blue-icon.svg" alt="" >
719              </figure>
720                                      <h3 class="understanding__heading">With rapidly progressing ADPKD, kidney function worsens and cysts grow more quickly, leading to early kidney failure</h3>
721                        <div class="understanding__content">
722              <ul><li>According to the Mayo Clinic ADPKD study, out of 538 patients, ~2/3 of this group were at risk for rapid progression</li></ul>
723            </div>
724          </div>
725          </div>
726        </article>
727      </div>
728      </div>
729</div>
730                          <div class="field--item">  <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default gs-animation-paragraph" id="paragraph-5651" data-test='paragraph'>
731                            
732
733
734
735
736              <h2>Why does kidney size matter?</h2>
737      
738
739
740
741
742
743  
744    
745                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
746                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--block paragraph--view-mode--default" id="paragraph-5646" >
747          
748
749
750
751
752  
753                        <div  class="field field--name-field-block field--type-entity-reference field--label-hidden">
754                          <div class="field--item"><div class="gs-animation-wrapper">
755  <div class="gs-animation-wrapper__animation">
756    <div id="desContainer_C2" class="des-container">
757      <div id="diseaseEducationSlider_C2" class="disease-education-sli
757der">
758        <div class="scene-wrapper" style="opacity: 0">
759          <div class="scene">
760
761            <div id="desPic1_C2" class="des-pic">
762              <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney1.png" alt="Kidney 1">
763            </div>
764            <div id="desPic2_C2" class="des-pic">
765              <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney2.png" alt="Kidney 2">
766            </div>
767            <div id="desPic3_C2" class="des-pic">
768              <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney3.png" alt="Kidney 3">
769            </div>
770            <div id="desPic4_C2" class="des-pic">
771              <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/gs-animation/kidney4.png" alt="Kidney 4">
772            </div>
773
774            <div class="des-text-under-line des-text-under-line-first">
775              <p>Kidney function (eGFR)</p>
776            </div>
777            <div class="des-text-under-line des-text-under-line-second">
778              <p>Kidney size <br />(total kidney <br />volume)</p>
779            </div>
780
781
782
783            <div id="desLineWrapper1_C2" class="des-line-wrapper">
784              <svg class="des-top-arrow-dot" width="11" height="11" viewB
784ox="0 0 11 11" fill="none" xmlns="http://www.w3.org/2000/svg">
785                <mask id="mask0_2003_504" style="mask-type:luminance" maskUnits="userSpaceOnUse" x="0" y="0" width="11" height="11">
786                  <path d="M0.659912 5.20875C0.659912 7.96875 2.88991 10.1988 5.64991 10.1988C8.40991 10.1988 10.6399 7.96875 10.6399 5.20875C10.6399 2.44875 8.40991 0.21875 5.64991 0.21875C2.88991 0.21875 0.659912 2.44875 0.659912 5.20875Z" fill="white"/>
787                </mask>
788                <g mask="url(#mask0_2003_504)">
789                  <path d="M10.6399 0.21875H0.659912V10.1988H10.6399V0.21875Z" fill="url(#paint0_linear_2003_504)"/>
790                </g>
791                <defs>
792                  <linearGradient id="paint0_linear_2003_504" x1="0.0799121" y1="3.12776" x2="393.067" y2="3.12776" gradientUnits="userSpaceOnUse">
793                    <stop stop-color="#4F9342"/>
794                    <stop offset="0.02" stop-color="#4F9342"/>
795                    <stop offset="1" stop-color="#FFC62F"/>
796                  </linearGradient>
797                </defs>
798              </svg>
799              <svg id="desLine1_C2" class="des-line" width="796" height="530" viewBox="0 0 796 530" fill="none" xmlns="http://www.w3.org/2000/svg">
800                <path id="desLine1Template_C2" class="des-line--template" d="M2 173.5L448.174 173.5C476.542 173.5 503.085 187.489 519.119 210.891L722 507" stroke="#444" stroke-width="1"/>
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806                    <stop offset="0.692708" stop-color="#D12229"/>
807                  </linearGradient>
808                </defs>
809                <g id="desLineArrow1_C2" class="des-line--arrow">
810                  <svg width="12" height="22" viewBox="0 0 12 22" fill="none" xmlns="http://www.w3.org/2000/svg">
811                    <path d="M0.579956 21.4775L11.62 11.2075L0.579956 0.9375V21.4775Z" fill="white"/>
812                  </svg>
813                </g>
814              </svg>
815            </div>
816
817            <div id="desLineWrapper2_C2" class="des-line-wrapper">
818              <svg class="des-bottom-arrow-dot" width="11" height="11" viewB
818ox="0 0 11 11" fill="none" xmlns="http://www.w3.org/2000/svg">
819                <mask id="mask0_2003_504" style="mask-type:luminance" maskUnits="userSpaceOnUse" x="0" y="0" width="11" height="11">
820                  <path d="M0.659912 5.20875C0.659912 7.96875 2.88991 10.1988 5.64991 10.1988C8.40991 10.1988 10.6399 7.96875 10.6399 5.20875C10.6399 2.44875 8.40991 0.21875 5.64991 0.21875C2.88991 0.21875 0.659912 2.44875 0.659912 5.20875Z" fill="#0D5362"/>
821                </mask>
822                <g mask="url(#mask0_2003_504)">
823                  <path d="M10.6399 0.21875H0.659912V10.1988H10.6399V0.21875Z" fill="#0D5362"/>
824                </g>
825              </svg>
826              <svg id="desLine2_C2" class="des-line" width="792" height="237" viewBox="0 0 792 237" fill="none" xmlns="http://www.w3.org/2000/svg">
827                <path id="desLine2Template_C2" class="des-line--template" d="M3.49998 210.5C257 187 553.5 99.5 782 2.50001" stroke="#444" stroke-width="1"/>
828                <path id="desLine2Path_C2" class="des-line--path" d="M3.49998 210.5C257 187 553.5 99.5 782 2.50001" stroke="#0D5362" stroke-width="2"/>
829                <g id="desLineArrow2_C2" class="des-line--arrow">
830                  <svg width="12" height="22" viewBox="0 0 12 22" fill="none" xmlns="http://www.w3.org/2000/svg">
831                    <path d="M0.579956 21.4775L11.62 11.2075L0.579956 0.9375V21.4775Z" fill="#0D5362"/>
832                  </svg>
833                </g>
834              </svg>
835            </div>
836
837          </div>
838
839          <div class="timeline-wrapper">
840            <form>
841              <label for="timeRange" class="hidden">Time Range</label>
842              <input type="range" min="0" max="1" step="0.01" value="0" id="timeRange" class="timeline" />
843            </form>
844          </div>
845
846          <div class="timeline-text">Time</div>
847        </div>
848      </div>
849    </div>
850    <div class="des-bottom-text">Slide the yellow dot above to see the growth of kidney size over time</div>
851  </div>
852  <div class="gs-animation-wrapper__text">
853    <p>In ADPKD, kidney growth caused by cysts often happens before your kidney function decline appears. Kidney function, measured by estimated glomerular filtration rate (eGFR), may remain stable while your kidneys continue to grow and can mask the irreversible damage. Because of this, kidney size, or total kidney volume (TKV), is the best predictor of ADPKD progression.</p>
854    <p>Your nephrologist can use an ultrasound, magnetic resonance imaging (MRI), or computed tomography (CT) to measure your kidney size and determine your risk of ADPKD progression.</p>
855  </div>
856</div>
857<div class="gs-animation-button-wrapper">
858  <button type="button" data-toggle="modal" data-target="#predictProgression">
859    Learn how kidney size is used to&nbsp;predict ADPKD progression
860  </button>
861</div>
862
863<!-- Modal -->
864<div class="modal fade predict-progression" id="predictProgression" tabindex="-1" role="dialog" aria-labelledby="predictProgressionModalLabel" aria-hidden="true">
865  <div class="modal-dialog content-dialog" role="document" data-test='modal'>
866    <div class="modal-content">
867      <button data-test='modal-close'
868        type="button"
869        class="close"
870        data-dismiss="modal"
871        aria-label="Close"
872        data-analytics-name="Close"
873      ></button>
874      <div class="modal-body" data-test='modal-body'>
875        <h2 data-test='modal-title'>How is kidney size used to predict ADPKD progression?</h2>
876        <p>Your nephrologist will take your total kidney volume (TKV) and adjust it based on your height to determine your risk of disease progression. This measurement is called a height-adjusted total kidney volume, or hTKV.</p>
877        <p>For example, two people may have the same size kidneys, but the shorter person may be at greater risk for rapid disease progression. Or, two people may have the same size kidneys and same height, but if one is younger, that person may be at risk for faster disease progression.</p>
878        <div class="predict-progression__patients">
879          <img class="d-md-none" alt="Patient 1, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-1.svg" />
880          <img class="d-md-none" alt="Patient 2, 70 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-2.svg" />
881          <img class="d-md-none" alt="Patient 3, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-3.svg" />
882          <img class="d-none d-md-block" alt="Patient 1, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-1-desktop.svg" />
883          <img class="d-none d-md-block" alt="Patient 2, 70 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-2-desktop.svg" />
884          <img class="d-none d-md-block" alt="Patient 3, 35 years old" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/patient-3-desktop.svg" />
885        </div>
886        <p>After determining your hTKV, your nephrologist may use your age and hTKV on a tool called the Mayo Imaging Classification chart to help predict your rate of disease progression.</p>
887        <img class="d-md-none" alt="Risk of Rapid Progression, Graph" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/TKV-Chart-Mobile.svg" />
888        <img class="d-none d-md-block" alt="Risk of Rapid Progression, Graph" src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/risk-of-rapid-progression-graph.svg" />
889      </div>
890    </div>
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904      
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917</div>
918                          <div class="field--item">  <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4746" data-test='paragraph'>
919                            
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924              <h2>Assessing your ADPKD progression</h2>
925      
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946          
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951  
952                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
953                          <div class="field--item"><h3>Is your eGFR rapidly declining?</h3><h4>Your ADPKD could already be rapidly progressing.</h4><p>A person with ADPKD is considered to be already rapidly progressing when their eGFR (a test result that measures how well the kidneys work) declines quickly.</p><p>eGFR is declining quickly when it drops: ≥ 3 mL/min/1.73 m<sup>2</sup> per year over a 3-5 year period.</p></div>
954                      </div>
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957      </div>
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969</div>
970                          <div class="field--item">  <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default icon-with-text-group" id="paragraph-4856" data-test='paragraph'>
971                  <div class="container">
972                        <div class="row">
973                  
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982                              <div class="field--item">  <div class="container clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-4776" >
983          
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988  
989                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
990                          <div class="field--item"><h2 class="mb-3 mb-md-3">Is your eGFR stable?</h2><p class="mb-4 ff-lato-500-mobile">You could still be at risk of rapidly progressing ADPKD.</p><p class="ff-lato-500-mobile">There are a number of factors that may put someone already living with ADPKD at <strong>risk of rapid ADPKD progression</strong>. These may include:</p></div>
991                      </div>
992              
993  
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995</div>
996                              <div class="field--item">  <div class="container simple-text-options-wrapper columns 2-columns two-columns clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4851" >
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1016                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--simple-text-option paragraph--view-mode--default" id="paragraph-4781" >
1017      <div class="container">
1018    <div class="d-block d-lg-none d-xl-none">
1019      
1020    </div>
1021    <div class="sto">
1022      <div class="sto-image">
1023
1024
1025
1026
1027                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/kidney-volume-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1030      </div>
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1039
1040  
1041                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1042                          <div class="field--item"><p class="ff-lato-500-mobile">Kidneys that are bigger than normal for a person's age with ADPKD (high total kidney volume)</p></div>
1043                      </div>
1044              
1045  
1046                              </div>
1047    </div>
1048  </div>
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1050</div>
1051                          </div>
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1077                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/genetic-mutation-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1079
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1082        <div class="d-none d-lg-block d-xl-block">
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1090  
1091                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1092                          <div class="field--item"><p class="ff-lato-500-mobile">Certain types of genetic mutations</p></div>
1093                      </div>
1094              
1095  
1096                              </div>
1097    </div>
1098  </div>
1099  </div>
1100</div>
1101                          </div>
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1117      <div class="container">
1118    <div class="d-block d-lg-none d-xl-none">
1119      
1120    </div>
1121    <div class="sto">
1122      <div class="sto-image">
1123
1124
1125
1126
1127                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/family-history-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1130      </div>
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1132        <div class="d-none d-lg-block d-xl-block">
1133          
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1139
1140  
1141                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1142                          <div class="field--item"><p class="ff-lato-500-mobile">Family members with ADPKD and a history of kidney failure, such as the need for dialysis or a kidney transplant, before age 58</p></div>
1143                      </div>
1144              
1145  
1146                              </div>
1147    </div>
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1167      <div class="container">
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1177                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/high-blood-pressure-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1190  
1191                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1192                          <div class="field--item"><p class="ff-lato-500-mobile">High blood pressure that started before the age of 35</p></div>
1193                      </div>
1194              
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1196                              </div>
1197    </div>
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1199  </div>
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1218d-block d-lg-none d-xl-none">
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1227                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/symptoms-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1230      </div>
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1241                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1242                          <div class="field--item"><p class="ff-lato-500-mobile">Blood in urine (hematuria), cyst infections, or flank pain related to cysts, before age 35</p></div>
1243                      </div>
1244              
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1247    </div>
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1277                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/weight-scale-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1291                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1292                          <div class="field--item"><p class="ff-lato-500-mobile">Being overweight, with a body mass index ≥25 kg/m<sup>2</sup></p></div>
1293                      </div>
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1327                <img loading="lazy" src="sites/g/files/qhldwo12166/files/2025-04/side-effects-yellow-icon.svg" alt="" typeof="foaf:Image" class="img-fluid" />
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1330      </div>
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1340  
1341                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1342                          <div class="field--item"><p class="ff-lato-500-mobile">Protein and albumin in urine (proteinuria and albuminuria)</p></div>
1343                      </div>
1344              
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1346                              </div>
1347    </div>
1348  </div>
1349  </div>
1350</div>
1351                          </div>
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1356                          </div>
1357                  
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1360</div>
1361                          </div>
1362                  
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1365                      </div>
1366            </div>
1367</div>
1368                          <div class="field--item">  
1369
1370  <div class="clearfix container" id="paragraph-4861" data-test='card'>
1371    <div class="border-box">
1372                          <h2 class="border-box__heading">Be Proactive</h2>
1373        
1374        <div class="border-box__text">
1375          <p class="mb-0 fw-900">
1375Wherever you are in your ADPKD journey, it's important to talk with your nephrologist to develop an appropriate treatment plan for your individual situation.</p><p class="fw-600 ff-lato-600-mobile">The sooner you start, the sooner you can help take control of your ADPKD and may start to experience the benefits of slowing down your disease progression. Don't wait, take the first step today. Make a plan to have a discussion about what you can do to help manage your ADPKD at your next appointment.</p>
1376        </div>
1377          </div>
1378  </div>
1379</div>
1380                          <div class="field--item">  <div class="container paragraph-link-bg type-b link-paragraph button clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-4876" data-test='paragraph'>
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1390                              <div class="field--item">  <div class="container clearfix paragraph paragraph--type--link paragraph--view-mode--default" id="paragraph-4871" >
1391          
1392
1393
1394
1395
1396              <h3 class="mb-md-4 pb-1">If you have any of these risk factors,</h3>
1397      
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1400
1401
1402  
1403                        <div  class="field field--name-field-link field--type-link field--label-hidden">
1404                          <div class="field--item"><a href="is-jynarque-for-you.html">See if JYNARQUE is right for you</a></div>
1405                      </div>
1406              
1407  
1408      </div>
1409</div>
1410                          </div>
1411                  
1412      
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1431  
1432                        <div  class="field field--name-field-link field--type-link field--label-hidden">
1433                          <div class="field--item"><a href="why-jynarque.html">Why JYNARQUE?</a></div>
1434                      </div>
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1437      </div>
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1468</span></div>
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1470      <div class="isi-inline-inner-wrap"><div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1470water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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1606<p>With the COVID-19 situation constantly developing, your health is our top priority. We hope that you and your families are staying safe and healthy during this unprecedented time.</p>
1607
1608<p>If you are currently taking JYNARQUE<sup>®</sup> (tolvaptan), we encourage you to stay in close contact with your healthcare professional team regarding regular appointments and treatment management plans.</p>
1609
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1611
1612<p>During the current COVID-19 <span class="text-nowrap">pandemic, the JYNARQUE<sup>®</sup> (tolvaptan)</span> REMS Program requirements remain in effect, as the health of patients who use this product is our top priority. Ongoing blood monitoring required by the REMS Program is extremely important due to the potential risk of serious liver injury from treatment with JYNARQUE. For these lab requirements during COVID-19 pandemic, we are able to temporarily offer our Mobile Phlebotomy Collection Service at no-cost for all patients taking JYNARQUE who prefer to have the REMS required blood work collected at home.</p>
1613
1614<p>In helping patients who have lost a job or health insurance coverage due to the COVID-19 pandemic and to get through these challenging times, we have extended our Patient Support Program to provide ‘no-cost’ access for patients in the U.S. who are taking JYNARQUE. Please call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a> for more information on both programs.</p>
1615
1616<p>For help accessing JYNARQUE, go to <a class="cta_exit" href="https://www.otsukapatientsupport.com/jynarque" target="_blank">www.otsukapatientsupport.com/jynarque</a> or call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a>. The nurses at Otsuka Patient Support can answer questions related to Product Accessibility, Reimbursement and connecting patients to local treatment sites in their community.</p>
1617
1618<p>Please read <a class="dummy external-link-popup-disabled" href="https://www.otsuka-u
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1619
1620<p class="covid-footnote"><span class="covid-prc-1">September&nbsp;2020</span><span class="covid-prc-2">10US20EBC0103</span></p>
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1647            <div class="drawer-title">IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)
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1657          <div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1657water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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1720<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.alert.js"></script>
vendor: 1 bytes, line 1720
1720
1721<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.button.js"></script>
vendor: 1 bytes, line 1721
1721
1722<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.dropdown.js"></script>
vendor: 1 bytes, line 1722
1722
1723<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/focus.advanced.js"></script>
vendor: 1 bytes, line 1723
1723
1724<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/otsuka-isi.js"></script>
vendor: 1 bytes, line 1724
1724
1725<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/interstitials.js"></script>
vendor: 1 bytes, line 1725
1725
1726<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/form-errors.js"></script>
vendor: 1 bytes, line 1726
1726
1727<script src="modules/custom/otsuka_facebook_api/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1727
1727
1728<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1728
1728
1729<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/src/js/opcm.js"></script>
vendor: 1 bytes, line 1729
1729
1730<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu-sticky.js"></script>
vendor: 1 bytes, line 1730
1730
1731<script src="modules/custom/pharma_isi/js/3rd-party/mCustomScrollbar/jquery.mCustomScrollbar.js"></script>
vendor: 1 bytes, line 1731
1731
1732<script src="modules/custom/pharma_isi/js/3rd-party/jquery.ba-throttle-debounce.min.js"></script>
vendor: 1 bytes, line 1732
1732
1733<script src="modules/custom/pharma_isi/js/pharma_isi_drawer.js"></script>
vendor: 1 bytes, line 1733
1733
1734<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/global.js"></script>
vendor: 1 bytes, line 1734
1734
1735<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu.main.js"></script>
vendor: 1 bytes, line 1735
1735
1736<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/node/node.landing-page.js"></script>
vendor: 1 bytes, line 1736
1736
1737<script src="modules/custom/otsuka_sfmc_registration/js/dist/otsuka_sfmc_preprocess.js"></script>
vendor: 1 bytes, line 1737
1737
1738<script src="modules/custom/pharma_isi/js/pharma_isi_inline.js"></script>
vendor: 1 bytes, line 1738
1738
1739<script src="modules/contrib/simple_popup_blocks/js/simple_popup_blocks.js"></script>
1739
1740
1741  
1741<script type="module" src="https://static.cloudflareinsights.com/beacon.min.js/v4bc70e2c01a94c73b74392e4234840661791215815920" integrity="sha512-L0ha0OXavK/8okipN9F8BtP84dg9DUhPERbBXzwI6dgTA55d2+yweo3pn5CSFYs45/r8md2+xvUPtTdvTNRfjA==" data-cf-beacon='{"version":"2024.11.0","token":"bf71ae886def4acf823e0389d7b92acb","spa":2}' crossorigin="anonymous"></script>
1741
1742</body>
1743
1744
1745</html>

Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.