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136"headline": ["Why JYNARQUE® (tolvaptan)?","Push back the progression of your ADPKD","With JYNARQUE, help slow the progression of your disease—across CKD stages","Patients taking JYNARQUE experienced less kidney pain"],
137"abstract": "For adults who are at risk for rapidly progressing ADPKD, JYNARQUE® (tolvaptan) is the only FDA-approved treatment that works to slow the decline of kidney function. Talk to your nephrologist to see how you can slow the progression of your ADPKD today.",
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166"guideline": ["It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver: before you start taking JYNARQUE, at 2 weeks and 4 weeks after you start treatment with JYNARQUE, then monthly for 18 months during treatment with JYNARQUE, and every 3 months from then on","Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the JYNARQUE Risk Evaluation and Mitigation Strategy (REMS) Program.","Do not take JYNARQUE if you: have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease, cannot feel if you are thirsty or cannot replace fluids by drinking, have been told that the amount of sodium (salt) in your blood is too high or too low, are dehydrated, are allergic to tolvaptan or any of the ingredients in JYNARQUE, are unable to urinate"],
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451                      </li>
452                      <li class="menu-item menu-item-2 menu-item--active-trail nav-item">
453                  <a href="why-jynarque.html" data-drupal-link-system-path="node/6" class="is-active" aria-current="page">Why JYNARQUE?</a>
454                      </li>
455                      <li class="menu-item menu-item-3 nav-item">
456                  <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a>
457                      </li>
458                      <li class="menu-item menu-item-4 nav-item">
459                  <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a>
460                      </li>
461                      <li class="menu-item menu-item-5 nav-item">
462                  <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a>
463                      </li>
464        </ul>
465  
466              </li>
467                      <li class="menu-item menu-item-2 menu-item--expanded nav-item">
468                  <a href="#"><span>Getting Started</span></a>
469                                        <ul class="menu nav">
470                          <li class="menu-item menu-item-1 nav-item">
471                  <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a>
472                      </li>
473                      <li class="menu-item menu-item-2 nav-item">
474                  <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a>
475                      </li>
476                      <li class="menu-item menu-item-3 nav-item">
477                  <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a>
478                      </li>
479                      <li class="menu-item menu-item-4 nav-item">
480                  <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a>
481                      </li>
482        </ul>
483  
484              </li>
485                      <li class="menu-item menu-item-3 nav-item">
486                  <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a>
487                      </li>
488                      <li class="menu-item menu-item-4 menu-item--expanded nav-item">
489                  <a href="#"><span>Resources</span></a>
490                                        <ul class="menu nav">
491                          <li class="menu-item menu-item-1 nav-item">
492                  <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a>
493                      </li>
494                      <li class="menu-item menu-item-2 nav-item">
495                  <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a>
496                      </li>
497        </ul>
498  
499              </li>
500        </ul>
501  
502
503
504  </nav>
505
506    <a href="#" class="mobile-menu-open-btn" data-test='mobile-menu-toggle'>
507      <span>Mobile menu</span>
508    </a>
509    <a href="#" class="mobile-menu-close-btn">
510      <span>Mobile menu</span>
511    </a>
512  </div>
513
514        </div>
515      </div>
516      </header>
517
518  <div id="mobile-menu" class="region--mobile-menu" data-analytics-position="header">
519    <div class="container">
520        <div class="region region-mobile-menu clearfix">
521    <nav role="navigation" aria-labelledby="block-mainnavigation-menu" id="block-mainnavigation">
522            
523  <h2 class="visually-hidden" id="block-mainnavigation-menu">Main navigation</h2>
524  
525
526        
527              <ul data-block="block-mainnavigation" data-test="main-menu" class="menu menu-main nav">
528                          <li class="menu-item menu-item-1 menu-item--expanded menu-item--active-trail nav
528-item">
529                  <a href="#"><span>About JYNARQUE</span></a>
530                                        <ul class="menu nav">
531                          <li class="menu-item menu-item-1 nav-item">
532                  <a href="understanding-adpkd-progression.html" data-drupal-link-system-path="node/37481">Understanding ADPKD & Progression</a>
533                      </li>
534                      <li class="menu-item menu-item-2 menu-item--active-trail nav-item">
535                  <a href="why-jynarque.html" data-drupal-link-system-path="node/6" class="is-active" aria-current="page">Why JYNARQUE?</a>
536                      </li>
537                      <li class="menu-item menu-item-3 nav-item">
538                  <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a>
539                      </li>
540                      <li class="menu-item menu-item-4 nav-item">
541                  <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a>
542                      </li>
543                      <li class="menu-item menu-item-5 nav-item">
544                  <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a>
545                      </li>
546        </ul>
547  
548              </li>
549                      <li class="menu-item menu-item-2 menu-item--expanded nav-item">
550                  <a href="#"><span>Getting Started</span></a>
551                                        <ul class="menu nav">
552                          <li class="menu-item menu-item-1 nav-item">
553                  <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a>
554                      </li>
555                      <li class="menu-item menu-item-2 nav-item">
556                  <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a>
557                      </li>
558                      <li class="menu-item menu-item-3 nav-item">
559                  <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a>
560                      </li>
561                      <li class="menu-item menu-item-4 nav-item">
562                  <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a>
563                      </li>
564        </ul>
565  
566              </li>
567                      <li class="menu-item menu-item-3 nav-item">
568                  <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a>
569                      </li>
570                      <li class="menu-item menu-item-4 menu-item--expanded nav-item">
571                  <a href="#"><span>Resources</span></a>
572                                        <ul class="menu nav">
573                          <li class="menu-item menu-item-1 nav-item">
574                  <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a>
575                      </li>
576                      <li class="menu-item menu-item-2 nav-item">
577                  <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a>
578                      </li>
579        </ul>
580  
581              </li>
582        </ul>
583  
584
585
586  </nav>
587
588  </div>
589
590    </div>
591  </div>
592  <section aria-label="Header Information">
593    <div id="header-info" class="region--header-info">
594      <div class="container">
595          <div class="region region-header-info clearfix">
596    <div id="block-jynarque-hcc-2021-headertextdescription" class="block-content-header-text-description block-content-basic block block-block-content block-block-content855941ea-329b-4a19-bc10-2bd1df83da5c block-header-text-description">
597  
598    
599      <div class="content">
600      
601
602
603
604
605  
606                        <div  class="field field--name-body field--type-text-with-summary field--label-hidden">
607                          <div class="field--item"><p>Proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD</p></div>
608                      </div>
609              
610  
611    </div>
612  </div>
613
614  </div>
615
616      </div>
617    </div>
618  </section>
619
620
621    <main role="main" class="main-content" id="main-content">
622                    <div class="container">
623            <div class="region region-highlighted clearfix">
624    <div data-drupal-messages-fallback class="hidden"></div>
625
626  </div>
627
628        </div>
629                    <div class="no-sidebar">
630            <div class="region region-content clearfix">
631    <div id="block-jynarque-hcc-2021-content" class="block block-system block-system-main-block">
632  
633    
634      <div class="content">
635      
636
637<article data-history-node-id="6" about="/why-jynarque" class="node node-type-landing-page node-view-mode-full">
638
639  
640    
641
642  
643            <div class="hero-section">
644        
645        
646      </div>
647    
648    <div class="node-content">
649      
650
651
652
653<div  class="field field--name-field-formatted-title field--type-text-long field--label-hidden container" data-test='paragraph'>
654      <div class="field--item">
655      <h1 class="title-inline-line"><span>Why</span> <span><strong>JYNARQUE<sup>®</sup> (tolvaptan)?</strong></span></h1>
656
657    </div>
658  </div>
659
660
661
662
663
664  
665                        <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
666                          <div class="field--item">  <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default why-jynarque-subtitle-block" id="paragraph-2646" data-test='paragraph'>
667                            
668
669
670
671
672              <h2><strong>Push back the progression of your ADPKD with JYNARQUE</strong></h2>
673      
674
675
676
677
678
679  
680    
681                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
682                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-2641" >
683          
684
685
686
687
688  
689                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
690                          <div class="field--item"><p>Tolvaptan is a <span class="blue-text font-weight-bold">recommended treatment</span> by the KDIGO Clinical Practice Guideline for the Evaluation, Management, and Treatment of ADPKD. The guidelines offer clear, research-based recommendations to help patients and doctors make informed decisions.</p></div>
691                      </div>
692              
693  
694      </div>
695</div>
696                          </div>
697                  
698      
699                    </div>
700</div>
701                          <div class="field--item">  <div class="clearfix paragraph paragraph--type--from-library paragraph--view-mode--default" id="paragraph-2281" data-test='paragraph'>
702          
703
704
705
706
707  
708                        <div  class="field field--name-paragraphs field--type-entity-reference-revisions field--label-hidden">
709                          <div class="field--item">  <div class="clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default h-100 bigger-container" id="paragraph-2276" >
710                  <div class="container">
711                        <div class="row">
712                  
713
714
715
716
717
718              <div class="col-12 clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-2271" >
719                            
720
721
722
723
724              <h2 class="font-weight-normal">JYNARQUE slowed the decline of kidney function by</h2>
725      
726
727
728
729
730
731              <div class="clearfix paragraph paragraph--type--persentage-text-top paragraph--view-mode--default" id="paragraph-2266" >
732      <div class="percentage_text_top">
733    <div class="percentage_text_top__top_section">
734      
735
736
737
738
739  
740                        <div  class="field field--name-field-left-percentage field--type-text field--label-hidden">
741                          <div class="field--item">35<sup>%</sup></div>
742                      </div>
743              
744  
745      <div class="percentage_text_top__top_section--content">
746        
747
748
749
750
751  
752                        <div  class="field field--name-field-left-text field--type-text-long field--label-hidden">
753                          <div class="field--item"><p>as seen in REPRISE, a 1-year clinical study of patients with<br class="desktop-only">
754CKD stages 2 to 4, vs placebo*</p>
755</div>
756                      </div>
757              
758  
759
760        <div class="d-none d-md-block">
761          
762
763
764
765
766  
767                        <div  class="field field--name-field-left-footnote field--type-text-long field--label-hidden">
768                          <div class="field--item"><p class="footnote mt-lg-2 mb-0">Treatment effect: 1.3 mL/min/1.73 m<sup>2</sup>​/​year (95% Cl: 0.86-1.68, <em>P</em>&lt;.0001).<br class="desktop-only">
769-2.3 mL/min/1.73 m<sup>2</sup>‌​/year with JYNARQUE vs -3.6 mL/min/1.73 m<sup>2</sup>‌​/​year with placebo.</p>
770</div>
771                      </div>
772              
773  
774        </div>
775      </div>
776      <div class="d-md-none">
777        
778
779
780
781
782  
783                        <div  class="field field--name-field-left-footnote field--type-text-long field--label-hidden">
784                          <div class="field--item"><p class="footnote mt-lg-2 mb-0">Treatment effect: 1.3 mL/min/1.73 m<sup>2</sup>​/​year (95% Cl: 0.86-1.68, <em>P</em>&lt;.0001).<br class="desktop-only">
785-2.3 mL/min/1.73 m<sup>2</sup>‌​/year with JYNARQUE vs -3.6 mL/min/1.73 m<sup>2</sup>‌​/​year with placebo.</p>
786</div>
787                      </div>
788              
789  
790      </div>
791    </div>
792    <div class="percentage_text_top__bottom_section">
793      
794
795
796
797
798  
799                        <div  class="field field--name-field-right-percentage field--type-text field--label-hidden">
800                          <div class="field--item">26<sup>%</sup></div>
801                      </div>
802              
803  
804      <div class="percentage_text_top__bottom_section--content">
805        
806
807
808
809
810  
811                        <div  class="field field--name-field-right-text field--type-text-long field--label-hidden">
812                          <div class="field--item"><p>as seen in TEMPO 3:4, a 3-year clinical study of patients<br class="desktop-only">
813with CKD stages 1 to 3, vs placebo*</p>
814</div>
815                      </div>
816              
817  
818
819        <div class="d-none d-md-block">
820          
821
822
823
824
825  
826                        <div  class="field field--name-field-right-footnote field--type-text-long field--label-hidden">
827                          <div class="field--item"><p class="footnote mt-lg-2">Treatment effect: 1.0 mL/min/1.73 m<sup>2</sup>​/​year (95% CI: 0.6-1.4, <em>P</em>&lt;.001).<br class="desktop-only">
828-2.7 mL/min/1.73 m<sup>2</sup>‌​/year with JYNARQUE vs -3.7 mL/min/1.73 m<sup>2</sup>‌​/​year with placebo.</p>
829</div>
830                      </div>
831              
832  
833        </div>
834      </div>
835      <div class="d-md-none">
836        
837
838
839
840
841  
842                        <div  class="field field--name-field-right-footnote field--type-text-long field--label-hidden">
843                          <div class="field--item"><p class="footnote mt-lg-2">Treatment effect: 1.0 mL/min/1.73 m<sup>2</sup>​/​year (95% CI: 0.6-1.4, <em>P</em>&lt;.001).<br class="desktop-only">
844-2.7 mL/min/1.73 m<sup>2</sup>‌​/year with JYNARQUE vs -3.7 mL/min/1.73 m<sup>2</sup>‌​/​year with placebo.</p>
845</div>
846                      </div>
847              
848  
849      </div>
850    </div>
851    <div class="percentage_text_top__central-line"></div>
852    <div class="percentage_text_top__horizontal-line"></div>
853  </div>
854  </div>
855
856      
857                    </div>
858
859      
860                  </div>
861                      </div>
862            </div>
863</div>
864                      </div>
865              
866  
867      </div>
868</div>
869                          <div class="field--item">  <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-2636" data-test='paragraph'>
870                            
871
872
873
874
875              <h2 class="pt-2 pt-lg-0 mt-4 mt-lg-5">With JYNARQUE, help slow the progression of your disease—across CKD stages</h2>
876      
877
878
879
880
881
882  
883    
884                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
885                              <div class="field--item">  <div class="border-blue-block ckd-stages clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" style="background-color:#FFFBEF" id="paragraph-2181" >
886                            
887
888
889
890
891
892  
893    
894                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
895                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-2171" >
896          
897
898
899
900
901  
902                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
903                          <div class="field--item"><p>JYNARQUE is appropriate for adults who are at risk for rapidly progressing ADPKD, throughout CKD stages 1 to 4</p></div>
904                      </div>
905              
906  
907      </div>
908</div>
909                              <div class="field--item">  <div class="classy-desktop-only clearfix paragraph paragraph--type--inline-svg-image paragraph--view-mode--default" id="paragraph-2176" >
910          
911
912
913
914
915              <h3 class="text-center">STAGES OF CKD</h3>
916      
917
918
919
920
921              <div>
922  
923  
924
925
926
927
928              <svg xmlns="http://www.w3.org/2000/svg" width="501" height="90" viewBox="0 0 501 90" fill="none" aria-label="Stages of CKD">
929  <path d="M372.684 25.1133H254.776V65.7711H372.684V25.1133Z" fill="#003A70"></path>
930  <path d="M373.665 66.7535H253.935V24.1328H373.665V66.7535ZM255.758 64.9309H371.843V26.0956H255.758V64.9309Z" fill="#FCC531"></path>
931  <path d="M499.284 25.1133H381.376V65.7711H499.284V25.1133Z" fill="#003A70"></path>
932  <path d="M500.266 66.7535H380.535V24.1328H500.266V66.7535ZM382.358 64.9309H498.443V26.0956H382.358V64.9309Z" fill="#FCC531"></path>
933  <path d="M246.224 25.1133H128.316V65.7711H246.224V25.1133Z" fill="#003A70"></path>
934  <path d="M314.781 17.8242H312.959V8.85147H60.4596V17.8242H58.637V6.88867H314.781V17.8242Z" fill="#003A70"></path>
935  <path d="M239.074 0.298828H134.064V13.8982H239.074V0.298828Z" fill="#FFFCEF"></path>
936  <path d="M441.943 83.5781H185.798V72.6426H187.621V81.7555H440.12V72.6426H441.943
936V83.5781Z" fill="#003A70"></path>
937  <path d="M363.01 76.0059H269.217V89.6052H363.01V76.0059Z" fill="#FFFCEF"></path>
938  <path d="M141.635 13.0561V4.92449H139.112V1.2793H148.785V4.92449H146.262V13.0561H141.635Z" fill="#003A70"></path>
939  <path d="M149.907 1.14062C152.991 1.14062 156.216 1.14062 159.3 1.14062V4.64561H154.393V5.48681H159.02V8.7114H154.393V9.5526H159.3V13.0576C156.216 13.0576 152.991 13.0576 149.907 13.0576V1.14062Z" fill="#003A70"></path>
940  <path d="M165.609 10.3923V13.0561H161.123V1.2793C162.525 1.2793 164.067 1.2793 165.609 1.2793L167.993 4.64409L170.376 1.2793C171.778 1.2793 173.32 1.2793 174.862 1.2793V13.0561H170.376V10.3923L170.657 7.72848L168.834 10.3923H167.152L165.329 7.72848L165.609 10.3923Z" fill="#003A70"></path>
941  <path d="M176.405 13.0561V1.2793C178.367 1.2793 179.489 1.2793 181.452 1.2793C184.396 1.2793 187.06 2.26069 187.06 5.76568C187.06 9.27067 184.256 10.2521 181.452 10.2521H181.031V13.0561C179.489 13.0561 177.947 13.0561 176.405 13.0561ZM181.452 6.74708C182.153 6.74708 182.573 6.32648 182.573 5.76568C182.573 5.20488 182.153 4.78428 181.452 4.78428H180.891V6.74708H181.452Z" fill="#003A70"></path>
942  <path d="M200.659 7.02832C200.659 15.1599 187.901 15.3001 187.901 7.02832C188.041 -1.24345 200.659 -1.10325 200.659 7.02832ZM196.173 7.02832C196.173 4.22433 192.528 4.22433 192.528 7.02832C192.528 9.83231 196.173 9.69211 196.173 7.02832Z" fill="#003A70"></path>
943  <path d="M210.053 9.132C210.053 10.1134 211.455 10.1134 211.455 9.27219C211.455 8.8516 211.174 8.5712 210.754 8.5712H209.632V5.76721H210.613C211.034 5.76721 211.314 5.48681 211.314 5.20641C211.314 4.36522 210.193 4.36522 210.193 5.20641H205.987C205.987 2.54262 207.809 1.14062 210.894 1.14062C214.679 1.14062 215.941 3.10342 215.801 4.78581C215.801 5.76721 215.24 6.88881 214.399 7.029C215.52 7.4496 216.221 8.431 216.221 9.55259C216.221 12.4968 213.417 13.338 210.894 13.338C207.669 13.338 205.847 11.7958 205.847 9.132H210.053Z" fill="#003A70"></path>
944  <path d="M220.848 5.76658C220.848 6.60777 220.147 7.44897 219.025 7.44897C218.044 7.44897 217.343 6.60777 217.343 5.76658C217.343 4.78518 218.044 4.08418 219.025 4.08418C220.007 3.94398 220.848 4.64498 220.848 5.76658ZM220.848 11.5148C220.848 12.356 220.147 13.1972 219.025 13.1972C218.044 13.1972 217.343 12.356 217.343 11.5148C217.343 10.5334 218.044 9.83237 219.025 9.83237C220.007 9.69217 220.848 10.5334 220.848 11.5148Z" fill="#003A70"></path>
945  <path d="M226.736 1.14062H231.503V7.73H232.344C232.344 8.9918 232.344 10.1134 232.344 11.3752H231.503V13.0576H227.157V11.3752H221.969V7.4496L226.736 1.14062ZM227.297 7.73V6.74861L227.577 5.34661L225.895 7.73H227.297Z" fill="#003A70"></path>
946  <path d="M280.292 85.5385V88.7631C278.75 88.7631 277.208 88.7631 275.666 88.7631V76.9863C277.629 76.9863 278.89 76.9863 280.713 76.9863C283.657 76.9863 286.461 77.8275 286.461 81.3325C286.461 83.0149 285.76 84.1365 284.779 84.8375L286.742 88.4827V88.7631H282.115L280.573 85.6787H280.292V85.5385ZM280.853 82.0335C281.554 82.0335 281.975 81.8933 281.975 81.1923C281.975 80.6315 281.554 80.3511 280.853 80.3511H280.152V81.8933H280.853V82.0335Z" fill="#003A70"></path>
947  <path d="M288.144 76.8477C291.228 76.8477 294.453 76.8477 297.537 76.8477V80.3526H292.63V81.1938H297.257V84.4184H292.63V85.2596H297.537V88.7646C294.453 88.7646 291.228 88.7646 288.144 88.7646V76.8477Z" fill="#003A70"></path>
948  <path d="M299.36 88.7631V76.9863C301.322 76.9863 302.444 76.9863 304.407 76.9863C307.351 76.9863 310.015 77.9677 310.015 81.4727C310.015 84.9777 307.211 85.9591 304.407 85.9591H303.986V88.7631C302.444 88.7631 300.902 88.7631 299.36 88.7631ZM304.407 82.4541C305.108 82.4541 305.528 82.0335 305.528 81.4727C305.528 80.9119 305.108 80.4913 304.407 80.4913H303.846V82.4541H304.407Z" fill="#003A70"></path>
949  <path d="M315.763 85.5385V88.7631C314.221 88.7631 312.679 88.7631 311.136 88.7631V76.9863C313.099 76.9863 314.361 76.9863 316.184 76.9863C319.128 76.9863 321.932 77.8275 321.932 81.3325C321.932 83.0149 321.231 84.1365 320.249 84.8375L322.212 88.4827V88.7631H317.586L316.043 85.6787H315.763V85.5385ZM316.324 82.0335C317.025 82.0335 317.445 81.8933 317.445 81.1923C317.445 80.6315 317.025 80.3511 316.324 80.3511H315.763V81.8933H316.324V82.0335Z" fill="#003A70"></path>
950  <path d="M331.886 76.8477V80.3526H330.063C330.063 82.035 330.063 83.5772 330.063 85.3998H331.886V88.7646H323.474V85.3998H325.296C325.296 83.7174 325.296 82.1752 325.296 80.3526H323.474V76.9879H331.886V76.8477Z" fill="#003A70"></path>
951  <path d="M339.597 80.6322C339.597 80.2116 339.176 80.0714 338.615 80.0714C338.195 80.0714 337.634 80.2116 337.634 80.7724C337.634 81.193 337.914 81.3332 338.335 81.3332C340.859 81.4734 344.083 81.7538 344.083 84.9784C344.083 88.0628 341.139 89.0442 338.475 89.0442C335.531 89.0442 332.867 87.6422 332.867 84.698H337.494C337.494 85.2588 338.055 85.399 338.475 85.399C339.036 85.399 339.457 85.2588 339.457 84.8382C339.457 84.4176 339.176 84.2774 338.335 84.1372C335.812 83.8568 333.008 83.4362 333.008 80.3518C333.008 77.9684 335.531 76.5664 338.475 76.5664C341.56 76.5664 343.943 77.8282 343.943 80.6322H339.597Z" fill="#003A70"></path>
952  <path d="M345.625 76.8477C348.71 76.8477 351.934 76.8477 355.019 76.8477V80.3526H350.112V81.1938H354.738V84.4184H350.112V85.2596H355.019V88.7646C351.934 88.7646 348.71 88.7646 345.625 88.7646V76.8477Z" fill="#003A70"></path>
953  <path d="M247.065 66.7535H127.335V24.1328H247.065V66.7535ZM129.157 64.9309H245.243V26.0956H129.157V64.9309Z" fill="#FCC531"></path>
954  <path d="M119.624 25.1133H1.71606V65.7711H119.624V25.1133Z" fill="#003A70"></path>
955  <path d="M120.465 66.7535H0.734619V24.1328H120.465V66.7535ZM2.55721 64.9309H118.642V26.0956H2.55721V64.9309Z" fill="#FCC531"></path>
956  <path d="M58.7773 50.4897V46.5641L58.9175 43.9003L57.9361 44.8817L55.4125 41.9376L59.6185 37.4512H63.8244V50.6299H58.7773V50.4897Z" fill="white"></path>
957  <path d="M185.938 41.9382H181.171V41.798C181.171 38.4332 183.835 37.0312 186.639 37.0312C189.443 37.0312 191.967 38.4332 191.967 41.3774C191.967 43.7608 190.565 45.1628 189.023 46.5648H191.967V50.4904H181.171V47.1256C182.013 46.4246 186.779 42.3588 187.06 41.798C187.2 41.3774 187.06 41.097 186.779 41.097C186.499 40.9568 186.078 41.2372 186.078 41.798V41.9382H185.938Z" fill="white"></path>
958  <path d="M312.258 46.1446C312.258 47.2662 313.8 47.2662 313.8 46.2848C313.8 45.8642 313.52 45.4436 313.099 45.4436H311.837V42.3593H312.959C313.52 42.3593 313.66 41.9387 313.66 41.6583C313.66 40.8171 312.398 40.6769 312.398 41.6583H307.631C307.631 38.7141 309.734 37.1719 313.099 37.1719C317.305 37.1719 318.707 39.2749 318.567 41.2377C318.567 42.3593 318.006 43.4809 317.025 43.7613C318.287 44.1819 319.128 45.3034 319.128 46.7054C319.128 50.0702 316.043 50.9114 313.239 50.9114C309.734 50.9114 307.631 49.229 307.631 46.2848H312.258V46.1446Z" fill="white"></path>
959  <path d="M439.419 37.3105H444.606V44.6009H445.447C445.447 45.8627 445.447 47.2647 445.447 48.5265H444.746V50.4893H439.839V48.5265H434.091V44.3205L439.419 37.3105ZM440.12 44.6009V43.6195L440.4 42.0773L438.438 44.6009H440.12Z" fill="white"></path>
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967                              <div class="field--item">  <div class="classy-mobile-only clearfix paragraph paragraph--type--inline-svg-image paragraph--view-mode--default" id="paragraph-3411" >
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973              <h3 class="text-center">STAGES OF CKD</h3>
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978
979              <div>
980  
981  
982
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985
986              <svg xmlns="http://www.w3.org/2000/svg" width="304" height="88" viewBox="0 0 304 88" fill="none" aria-label="Stages of CKD">
987  <path d="M35 21.498V11.5273H60.7322" stroke="#103B71" stroke-width="2"></path>
988  <path d="M70.0727 17.2514V9.1198H67.5491V5.47461H77.2228V9.1198H74.6992V17.2514H70.0727Z" fill="#003A70"></path>
989  <path d="M78.3445 5.33594C81.4289 5.33594 84.6535 5.33594 87.7379 5.33594V8.84093H82.8309V9.68212H87.4574V12.9067H82.8309V13.7479H87.7379V17.2529C84.6535 17.2529 81.4289 17.2529 78.3445 17.2529V5.33594Z" fill="#003A70"></path>
990  <path d="M94.0467 14.5876V17.2514H89.5603V5.47461C90.9623 5.47461 92.5045 5.47461 94.0467 5.47461L96.4301 8.8394L98.8135 5.47461C100.215 5.47461 101.758 5.47461 103.3 5.47461V17.2514H98.8135V14.5876L99.0939 11.9238L97.2713 14.5876H95.5889L93.7663 11.9238L94.0467 14.5876Z" fill="#003A70"></path>
991  <path d="M104.842 17.2514V5.47461C106.805 5.47461 107.926 5.47461 109.889 5.47461C112.833 5.47461 115.497 6.45601 115.497 9.96099C115.497 13.466 112.693 14.4474 109.889 14.4474H109.469V17.2514C107.926 17.2514 106.384 17.2514 104.842 17.2514ZM109.889 10.9424C110.59 10.9424 111.011 10.5218 111.011 9.96099C111.011 9.4002 110.59 8.9796 109.889 8.9796H109.328V10.9424H109.889Z" fill="#003A70"></path>
992  <path d="M129.097 11.2236C129.097 19.3552 116.339 19.4954 116.339 11.2236C116.479 2.95186 129.097 3.09206 129.097 11.2236ZM124.61 11.2236C124.61 8.41964 120.965 8.41964 120.965 11.2236C120.965 14.0276 124.61 13.8874 124.61 11.2236Z" fill="#003A70"></path>
993  <path d="M138.49 13.3273C138.49 14.3087 139.892 14.3087 139.892 13.4675C139.892 13.0469 139.612 12.7665 139.191 12.7665H138.069V9.96252H139.051C139.471 9.96252 139.752 9.68212 139.752 9.40172C139.752 8.56053 138.63 8.56053 138.63 9.40172H134.424C134.424 6.73793 136.247 5.33594 139.331 5.33594C143.116 5.33594 144.378 7.29873 144.238 8.98112
993C144.238 9.96252 143.677 11.0841 142.836 11.2243C143.958 11.6449 144.659 12.6263 144.659 13.7479C144.659 16.6921 141.855 17.5333 139.331 17.5333C136.107 17.5333 134.284 15.9911 134.284 13.3273H138.49Z" fill="#003A70"></path>
994  <path d="M149.285 9.96189C149.285 10.8031 148.584 11.6443 147.463 11.6443C146.481 11.6443 145.78 10.8031 145.78 9.96189C145.78 8.98049 146.481 8.2795 147.463 8.2795C148.444 8.1393 149.285 8.84029 149.285 9.96189ZM149.285 15.7101C149.285 16.5513 148.584 17.3925 147.463 17.3925C146.481 17.3925 145.78 16.5513 145.78 15.7101C145.78 14.7287 146.481 14.0277 147.463 14.0277C148.444 13.8875 149.285 14.7287 149.285 15.7101Z" fill="#003A70"></path>
995  <path d="M155.174 5.33594H159.941V11.9253H160.782C160.782 13.1871 160.782 14.3087 160.782 15.5705H159.941V17.2529H155.594V15.5705H150.407V11.6449L155.174 5.33594ZM155.735 11.9253V10.9439L156.015 9.54192L154.333 11.9253H155.735Z" fill="#003A70"></path>
996  <path d="M193.464 21.498V11.5273H167.732" stroke="#103B71" stroke-width="2"></path>
997  <rect x="0.5" y="26.998" width="69" height="34" fill="#103B71"></rect>
998  <rect x="0.5" y="26.998" width="69" height="34" stroke="#FFC52E"></rect>
999  <path d="M34.1589 50.4468V46.5212L34.2991 43.8574L33.3177 44.8388L30.7941 41.8946L35.0001 37.4082H39.206V50.587H34.1589V50.4468Z" fill="white"></path>
1000  <rect x="78.5" y="26.998" width="69" height="34" fill="#103B71"></rect>
1001  <rect x="78.5" y="26.998" width="69" height="34" stroke="#FFC52E"></rect>
1002  <path d="M112.369 42.1755H107.602V42.0353C107.602 38.6706 110.266 37.2686 113.07 37.2686C115.874 37.2686 118.398 38.6705 118.398 41.6147C118.398 43.9981 116.996 45.4001 115.453 46.8021H118.398V50.7277H107.602V47.3629C108.443 46.6619 113.21 42.5961 113.491 42.0353C113.631 41.6147 113.491 41.3343 113.21 41.3343C112.93 41.1941 112.509 41.4745 112.509 42.0353V42.1755H112.369Z" fill="white"></path>
1003  <rect x="156.5" y="26.998" width="69" height="34" fill="#103B71"></rect>
1004  <rect x="156.5" y="26.998" width="69" height="34" stroke="#FFC52E"></rect>
1005  <path d="M189.878 46.1007C189.878 47.2223 191.421 47.2223 191.421 46.2409C191.421 45.8203 191.14 45.3997 190.72 45.3997H189.458V42.3153H190.579C191.14 42.3153 191.28 41.8947 191.28 41.6143C191.28 40.7731 190.019 40.6329 190.019 41.6143H185.252C185.252 38.6701 187.355 37.1279 190.72 37.1279C194.926 37.1279 196.328 39.2309 196.187 41.1937C196.187 42.3153 195.627 43.4369 194.645 43.7173C195.907 44.1379 196.748 45.2595 196.748 46.6615C196.748 50.0263 193.664 50.8675 190.86 50.8675C187.355 50.8675 185.252 49.1851 185.252 46.2409H189.878V46.1007Z" fill="white"></path>
1006  <rect x="234.5" y="26.998" width="69" height="34" fill="#103B71"></rect>
1007  <rect x="234.5" y="26.998" width="69" height="34" stroke="#FFC52E"></rect>
1008  <path d="M268.65 37.4082H273.837V44.6986H274.678C274.678 45.9604 274.678 47.3624 274.678 48.6242H273.977V50.587H269.07V48.6242H263.322V44.4182L268.65 37.4082ZM269.351 44.6986V43.7172L269.631 42.175L267.668 44.6986H269.351Z" fill="white"></path>
1009  <path d="M109.464 66.498V76.4688H144.232" stroke="#103B71" stroke-width="2"></path>
1010  <path d="M156.182 78.8334V82.058C154.64 82.058 153.097 82.058 151.555 82.058V70.2812C153.518 70.2812 154.78 70.2812 156.602 70.2812C159.547 70.2812 162.351 71.1224 162.351 74.6274C162.351 76.3098 161.65 77.4314 160.668 78.1324L162.631 81.7776V82.058H158.004L156.462 78.9736H156.182V78.8334ZM156.743 75.3284C157.444 75.3284 157.864 75.1882 157.864 74.4872C157.864 73.9264 157.444 73.646 156.743 73.646H156.042V75.1882H156.743V75.3284Z" fill="#003A70"></path>
1011  <path d="M164.033 70.1426C167.117 70.1426 170.342 70.1426 173.426 70.1426V73.6476H168.519V74.4888H173.146V77.7134H168.519V78.5545H173.426V82.0595C170.342 82.0595 167.117 82.0595 164.033 82.0595V70.1426Z" fill="#003A70"></path>
1012  <path d="M175.249 82.058V70.2812C177.212 70.2812 178.334 70.2812 180.296 70.2812C183.241 70.2812 185.904 71.2627 185.904 74.7676C185.904 78.2726 183.1 79.254 180.296 79.254H179.876V82.058C178.334 82.058 176.791 82.058 175.249 82.058ZM180.296 75.749C180.997 75.749 181.418 75.3284 181.418 74.7676C181.418 74.2068 180.997 73.7862 180.296 73.7862H179.736V75.749H180.296Z" fill="#003A70"></path>
1013  <path d="M191.653 78.8334V82.058C190.11 82.058 188.568 82.058 187.026 82.058V70.2812C188.989 70.2812 190.251 70.2812 192.073 70.2812C195.017 70.2812 197.821 71.1224 197.821 74.6274C197.821 76.3098 197.12 77.4314 196.139 78.1324L198.102 81.7776V82.058H193.475L191.933 78.9736H191.653V78.8334ZM192.213 75.3284C192.914 75.3284 193.335 75.1882 193.335 74.4872C193.335 73.9264 192.914 73.646 192.213 73.646H191.653V75.1882H192.213V75.3284Z" fill="#003A70"></path>
1014  <path d="M207.775 70.1426V73.6476H205.953C205.953 75.33 205.953 76.8721 205.953 78.6947H207.775V82.0595H199.363V78.6947H201.186C201.186 77.0123 201.186 75.4702 201.186 73.6476H199.363V70.2828H207.775V70.1426Z" fill="#003A70"></path>
1015  <path d="M215.486 73.9271C215.486 73.5065 215.066 73.3663 214.505 73.3663C214.084 73.3663 213.524 73.5065 213.524 74.0673C213.524 74.4879 213.804 74.6281 214.224 74.6281C216.748 74.7683 219.973 75.0487 219.973 78.2733C219.973 81.3577 217.028 82.3391 214.365 82.3391C211.421 82.3391 208.757 80.9371 208.757 77.9929H213.383C213.383 78.5537 213.944 78.6939 214.365 78.6939C214.925 78.6939 215.346 78.5537 215.346 78.1331C215.346 77.7125 215.066 77.5723 214.224 77.4321C211.701 77.1517 208.897 76.7311 208.897 73.6467C208.897 71.2633 211.421 69.8613 214.365 69.8613C217.449 69.8613 219.832 71.1231 219.832 73.9271H215.486Z" fill="#003A70"></path>
1016  <path d="M221.515 70.1426C224.599 70.1426 227.824 70.1426 230.908 70.1426V73.6476H226.001V74.4888H230.628V77.7134H226.001V78.5545H230.908V82.0595C227.824 82.0595 224.599 82.0595 221.515 82.0595V70.1426Z" fill="#003A70"></path>
1017  <path d="M273 66.498V76.4688H238.232" stroke="#103B71" stroke-width="2"></path>
1018</svg>
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1035                          <div class="field--item">  <div class="wrapper-oblique-line-back clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" style="background-color:#FFFBEF" id="paragraph-2581" data-test='paragraph'>
1036                  <div class="container">
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1069              <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/less-kidney-pain-desktop.png" type="image/png" sizes="100vw" width="790" height="642"/>
1070                  <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/less-kidney-pain-desktop.png" sizes="100vw" width="790" height="642" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/less-kidney-pain-desktop.png" alt="" typeof="foaf:Image" class="img-fluid" />
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1080</div>
1081                              <div class="field--item">  <div class="classy-mobile-only clearfix paragraph paragraph--type--image paragraph--view-mode--default" id="paragraph-5776" >
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1096              <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/less-kidney-pain-mobile.png" type="image/png" sizes="100vw" width="720" height="642"/>
1097                  <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/less-kidney-pain-mobile.png" sizes="100vw" width="720" height="642" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/less-kidney-pain-mobile.png" alt="" typeof="foaf:Image" class="img-fluid" />
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1131                          <div class="field--item"><h2 class="pt-1 pt-lg-0 mt-4 mt-lg-2 mb-lg-1 mb-xl-3 font-weight-normal">Patients taking JYNARQUE experienced less kidney pain</h2><p>In a clinical trial of patients with ADPKD, at CKD stages 1 to 3, those taking JYNARQUE were likely to experience</p></div>
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1137                              <div class="field--item">  <div class="percentage clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-2571" >
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1145                          <div class="field--item"><div class="percentage-primary">36<sup>%</sup></div><div class="percentage-text align-self-center"><h3><span class="blue-text font-weight-normal">fewer pain events</span></h3><p>9.9% of patients taking JYNARQUE had a pain event vs 16.2% of those taking placebo</p></div></div>
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1159                          <div class="field--item"><p><span style="white-space:pre-wrap;">Patient image is AI-generated.</span></p></div>
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1172                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
1173                          <div class="field--item"><h3 class="mt-3 pt-1 mt-lg-3 pt-lg-3 mb-3 mb-lg-0 text-center text-lg-left px-3 px-lg-0 font-weight-normal">Talk to your nephrologist to see how you can slow the progression of your ADPKD today</h3></div>
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1207                          <div class="field--item"><p class="mb-0 pb-1 mb-lg-3 footnote">CKD=chronic kidney disease; FDA=Food and Drug Administration; KDGIO=Kidney Disease Improving Global Outcomes.</p><p class="mb-2 footnote"><span class="hang">*</span>Kidney function was measured by the change in the average&nbsp;eGFR over time.</p></div>
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1236                          <div class="field--item"><a href="side-effects-rems.html">Learn about JYNARQUE side effects</a></div>
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1304      <div class="isi-inline-inner-wrap"><div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1304water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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1440<p>With the COVID-19 situation constantly developing, your health is our top priority. We hope that you and your families are staying safe and healthy during this unprecedented time.</p>
1441
1442<p>If you are currently taking JYNARQUE<sup>®</sup> (tolvaptan), we encourage you to stay in close contact with your healthcare professional team regarding regular appointments and treatment management plans.</p>
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1445
1446<p>During the current COVID-19 <span class="text-nowrap">pandemic, the JYNARQUE<sup>®</sup> (tolvaptan)</span> REMS Program requirements remain in effect, as the health of patients who use this product is our top priority. Ongoing blood monitoring required by the REMS Program is extremely important due to the potential risk of serious liver injury from treatment with JYNARQUE. For these lab requirements during COVID-19 pandemic, we are able to temporarily offer our Mobile Phlebotomy Collection Service at no-cost for all patients taking JYNARQUE who prefer to have the REMS required blood work collected at home.</p>
1447
1448<p>In helping patients who have lost a job or health insurance coverage due to the COVID-19 pandemic and to get through these challenging times, we have extended our Patient Support Program to provide ‘no-cost’ access for patients in the U.S. who are taking JYNARQUE. Please call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a> for more information on both programs.</p>
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1450<p>For help accessing JYNARQUE, go to <a class="cta_exit" href="https://www.otsukapatientsupport.com/jynarque" target="_blank">www.otsukapatientsupport.com/jynarque</a> or call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a>. The nurses at Otsuka Patient Support can answer questions related to Product Accessibility, Reimbursement and connecting patients to local treatment sites in their community.</p>
1451
1452<p>Please read <a class="dummy external-link-popup-disabled" href="https://www.otsuka-u
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1454<p class="covid-footnote"><span class="covid-prc-1">September&nbsp;2020</span><span class="covid-prc-2">10US20EBC0103</span></p>
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1481            <div class="drawer-title">IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)
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1491          <div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1491water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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1497
1498</section>
1499<style>
1500	
1501	.isi-tray {
1502		left: 0%;
1503		width: 100%;
1504	}
1505	.isi-drawer-expanded {
1506		height: 100px;
1507	}
1508	.isi-drawer-collapsed {
1509		height: 40px;
1510	}
1511
1512  .isi-tray.isi-drawer-expanded .isi-content-wrap,
1513  .isi-tray.isi-drawer-expanded .isi-content-wrap>div {
1514      height: calc(50vh - 220px);
1515  }
1516  @media all and (min-width: 768px) {
1517      .isi-tray.isi-drawer-expanded .isi-content-wrap,
1518      .isi-tray.isi-drawer-expanded .isi-content-wrap>div {
1519          height: calc(50vh - 60px);
1520      }
1521  }
1522</style>
1523
1524
1525    
1525<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/modernizr-custom.js"></script>
vendor: 1 bytes, line 1525
1525
1526<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/version-min.js"></script>
vendor: 1 bytes, line 1526
1526
1527<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/keycode-min.js"></script>
vendor: 1 bytes, line 1527
1527
1528<script src="modules/contrib/jquery_ui/assets/vendor/jquery.ui/ui/widgets/datepicker-min.js"></script>
vendor: 1 bytes, line 1528
1528
1529<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/focus.js"></script>
vendor: 1 bytes, line 1529
1529
1530<script src="modules/contrib/external_link_popup/js/dialog.js"></script>
vendor: 1 bytes, line 1530
1530
1531<script src="modules/contrib/extlink/extlink.js"></script>
vendor: 1 bytes, line 1531
1531
1532<script src="core/misc/progress.js"></script>
vendor: 1 bytes, line 1532
1532
1533<script src="core/assets/vendor/loadjs/loadjs.min.js"></script>
vendor: 1 bytes, line 1533
1533
1534<script src="core/misc/message.js"></script>
vendor: 1 bytes, line 1534
1534
1535<script src="core/misc/ajax.js"></script>
vendor: 1 bytes, line 1535
1535
1536<script src="modules/contrib/google_tag/js/gtag.ajax.js"></script>
vendor: 1 bytes, line 1536
1536
1537<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.util.js"></script>
vendor: 1 bytes, line 1537
1537
1538<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/link_tagging.js"></script>
vendor: 1 bytes, line 1538
1538
1539<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form_ls_confirmation.js"></script>
vendor: 1 bytes, line 1539
1539
1540<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form.js"></script>
vendor: 1 bytes, line 1540
1540
1541<script src="modules/custom/otsuka_ds/otsuka_ds_tagging/js/form_modal.js"></script>
vendor: 1 bytes, line 1541
1541
1542<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/analytics/analytics-form.js"></script>
vendor: 1 bytes, line 1542
1542
1543<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/analytics/analytics-custom.js"></script>
vendor: 1 bytes, line 1543
1543
1544<script src="https://cdn.jsdelivr.net/npm/[email protected]/dist/loadjs.umd.min.js"></script>
vendor: 1 bytes, line 1544
1544
1545<script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script>
vendor: 1 bytes, line 1545
1545
1546<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.collapse.js"></script>
vendor: 1 bytes, line 1546
1546
1547<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.alert.js"></script>
vendor: 1 bytes, line 1547
1547
1548<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.button.js"></script>
vendor: 1 bytes, line 1548
1548
1549<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.dropdown.js"></script>
vendor: 1 bytes, line 1549
1549
1550<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/bootstrap/bootstrap.modal.js"></script>
vendor: 1 bytes, line 1550
1550
1551<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/focus.advanced.js"></script>
vendor: 1 bytes, line 1551
1551
1552<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/otsuka-isi.js"></script>
vendor: 1 bytes, line 1552
1552
1553<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/component/interstitials.js"></script>
vendor: 1 bytes, line 1553
1553
1554<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/base/form-errors.js"></script>
vendor: 1 bytes, line 1554
1554
1555<script src="modules/custom/otsuka_facebook_api/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1555
1555
1556<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/facebook-api.js"></script>
vendor: 1 bytes, line 1556
1556
1557<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/src/js/opcm.js"></script>
vendor: 1 bytes, line 1557
1557
1558<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu-sticky.js"></script>
vendor: 1 bytes, line 1558
1558
1559<script src="modules/custom/pharma_isi/js/3rd-party/mCustomScrollbar/jquery.mCustomScrollbar.js"></script>
vendor: 1 bytes, line 1559
1559
1560<script src="modules/custom/pharma_isi/js/3rd-party/jquery.ba-throttle-debounce.min.js"></script>
vendor: 1 bytes, line 1560
1560
1561<script src="modules/custom/pharma_isi/js/pharma_isi_drawer.js"></script>
vendor: 1 bytes, line 1561
1561
1562<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/global.js"></script>
vendor: 1 bytes, line 1562
1562
1563<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/menu/menu.main.js"></script>
vendor: 1 bytes, line 1563
1563
1564<script src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/js/node/node.landing-page.js"></script>
vendor: 1 bytes, line 1564
1564
1565<script src="modules/custom/otsuka_sfmc_registration/js/dist/otsuka_sfmc_preprocess.js"></script>
vendor: 1 bytes, line 1565
1565
1566<script src="modules/custom/pharma_isi/js/pharma_isi_inline.js"></script>
vendor: 1 bytes, line 1566
1566
1567<script src="modules/contrib/simple_popup_blocks/js/simple_popup_blocks.js"></script>
1567
1568
1569  
1569<script type="module" src="https://static.cloudflareinsights.com/beacon.min.js/v4bc70e2c01a94c73b74392e4234840661791215815920" integrity="sha512-L0ha0OXavK/8okipN9F8BtP84dg9DUhPERbBXzwI6dgTA55d2+yweo3pn5CSFYs45/r8md2+xvUPtTdvTNRfjA==" data-cf-beacon='{"version":"2024.11.0","token":"bf71ae886def4acf823e0389d7b92acb","spa":2}' crossorigin="anonymous"></script>
1569
1570</body>
1571
1572
1573</html>

Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.