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131<script type="application/ld+json">{"@context": "https://schema.org", 132"@type": "MedicalWebPage", 133"audience": "Patient", 134"specialty": "Renal", 135"url": "https://www.jynarque.com/", 136"headline": ["Now is the time to push back the progression of ADPKD with JYNARQUE® (tolvaptan)","Treating your ADPKD","Connect with the ADPKD community","SAVE on your JYNARQUE"], 137"abstract": "For adults who are at risk for rapidly progressing ADPKD, JYNARQUE is the only FDA-approved treatment proven to work over a period of years to slow the decline of kidney function.", 138"description": "Talk to your nephrologist and learn how JYNARQUE is proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD.", 139"name": "Homepage", 140"breadcrumb": 141{"@type": "BreadcrumbList", 142"itemListElement": [{ 143"@type": "ListItem", 144"position": 1, 145"item": { 146"@id": "https://www.jynarque.com/", 147"name": "Homepage"}}]}, 148"mainContentOfPage": 149{"@type": "WebPageElement", 150"potentialAction": [{ 151"@type": "Action", 152"name": "See if JYNARQUE is right for you", 153"description": "In a Mayo Clinic ADPKD study that included 538 patients, 2 out of 3 people with ADPKD were at risk for rapid progression. 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menu-item--expanded nav-item"> 470 <a href="#"><span>Getting Started</span></a> 471 <ul class="menu nav"> 472 <li class="menu-item menu-item-1 nav-item"> 473 <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a> 474 </li> 475 <li class="menu-item menu-item-2 nav-item"> 476 <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a> 477 </li> 478 <li class="menu-item menu-item-3 nav-item"> 479 <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a> 480 </li> 481 <li class="menu-item menu-item-4 nav-item"> 482 <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a> 483 </li> 484 </ul> 485 486 </li> 487 <li class="menu-item menu-item-3 nav-item"> 488 <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a> 489 </li> 490 <li class="menu-item 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509 <span>Mobile menu</span> 510 </a> 511 <a href="#" class="mobile-menu-close-btn"> 512 <span>Mobile menu</span> 513 </a> 514 </div> 515 516 </div> 517 </div> 518 </header> 519 520 <div id="mobile-menu" class="region--mobile-menu" data-analytics-position="header"> 521 <div class="container"> 522 <div class="region region-mobile-menu clearfix"> 523 <nav role="navigation" aria-labelledby="block-mainnavigation-menu" id="block-mainnavigation"> 524 525 <h2 class="visually-hidden" id="block-mainnavigation-menu">Main navigation</h2> 526 527 528 529 <ul data-block="block-mainnavigation" data-test="main-menu" class="menu menu-main nav"> 530 <li class="menu-item menu-item-1 menu-item--expanded nav-item"> 531 <a href="#"><span>About JYNARQUE</span></a> 532 <ul class="menu nav"> 533 <li class="menu-item menu-item-1 nav-item"> 534 <a href="understanding-adpkd-progression.html" data-drupal-link-system-path="node/37481">Understanding ADPKD & Progression</a> 535 </li> 536 <li class="menu-item menu-item-2 nav-item"> 537 <a href="why-jynarque.html" data-drupal-link-system-path="node/6">Why JYNARQUE?</a> 538 </li> 539 <li class="menu-item menu-item-3 nav-item"> 540 <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a> 541 </li> 542 <li class="menu-item menu-item-4 nav-item"> 543 <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a> 544 </li> 545 <li class="menu-item menu-item-5 nav-item"> 546 <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a> 547 </li> 548 </ul> 549 550 </li> 551 <li class="menu-item menu-item-2 menu-item--expanded nav-item"> 552 <a href="#"><span>Getting Started</span></a> 553 <ul class="menu nav"> 554 <li class="menu-item menu-item-1 nav-item"> 555 <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a> 556 </li> 557 <li class="menu-item menu-item-2 nav-item"> 558 <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a> 559 </li> 560 <li class="menu-item menu-item-3 nav-item"> 561 <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a> 562 </li> 563 <li class="menu-item menu-item-4 nav-item"> 564 <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a> 565 </li> 566 </ul> 567 568 </li> 569 <li class="menu-item menu-item-3 nav-item"> 570 <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a> 571 </li> 572 <li class="menu-item menu-item-4 menu-item--expanded nav-item"> 573 <a href="#"><span>Resources</span></a> 574 <ul class="menu nav"> 575 <li class="menu-item menu-item-1 nav-item"> 576 <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a> 577 </li> 578 <li class="menu-item menu-item-2 nav-item"> 579 <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a> 580 </li> 581 </ul> 582 583 </li> 584 </ul> 585 586 587 588 </nav> 589 590 </div> 591 592 </div> 593 </div> 594 <section aria-label="Header Information"> 595 <div id="header-info" class="region--header-info"> 596 <div class="container"> 597 <div class="region region-header-info clearfix"> 598 <div id="block-jynarque-hcc-2021-headertextdescription" class="block-content-header-text-description block-content-basic block block-block-content block-block-content855941ea-329b-4a19-bc10-2bd1df83da5c block-header-text-description"> 599 600 601 <div class="content"> 602 603 604 605 606 607 608 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 609 <div class="field--item"><p>Proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD</p></div> 610 </div> 611 612 613 </div> 614 </div> 615 616 </div> 617 618 </div> 619 </div> 620 </section> 621 622 623 <main role="main" class="main-content" id="main-content"> 624 <div class="container"> 625 <div class="region region-highlighted clearfix"> 626 <div data-drupal-messages-fallback class="hidden"></div> 627 628 </div> 629 630 </div> 631 <div class="no-sidebar"> 632 <div class="region region-content clearfix">
633 <div id="block-jynarque-hcc-2021-content" class="block block-system block-system-main-block"> 634 635 636 <div class="content"> 637 638 639<article data-history-node-id="1" about="/node/1" class="node node-type-landing-page node--promoted node-view-mode-full"> 640 641 642 643 644 645 <div class="hero-section"> 646 647 648 649 650 651 652 <div class="field field--name-field-hero-media-mobile field--type-entity-reference field--label-hidden"> 653 <div class="field--item"><div> 654 655 656 657 658 659 660 <picture> 661 <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" type="image/webp" sizes="100vw" width="720" height="170"/> 662 <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" type="image/jpeg" sizes="100vw" width="720" height="170"/> 663 <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" sizes="100vw" width="720" height="170" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" alt="" typeof="foaf:Image" class="img-fluid" /> 664 665 </picture> 666 667 668 669</div> 670</div> 671 </div> 672 673 674 675 676 677 678 679 680 <div class="field field--name-field-hero-media-desktop field--type-entity-reference field--label-hidden"> 681 <div class="field--item"><div> 682 683 684 685 686 687 688 <picture> 689 <source srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" type="image/webp" sizes="100vw" width="2600" height="605"/> 690 <source srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" type="image/jpeg" sizes="100vw" width="2600" height="605"/> 691 <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" sizes="100vw" width="1440" height="335" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg" alt="" typeof="foaf:Image" class="img-fluid" /> 692 693 </picture> 694 695 696 697</div> 698</div> 699 </div> 700 701 702 </div> 703 704 <div class="node-content"> 705 706 707 708 709<div class="field field--name-field-formatted-title field--type-text-long field--label-hidden container" data-test='paragraph'> 710 <div class="field--item"> 711 <h1><span>Now is the time to</span> <span><strong>PUSH BACK THE PROGRESSION</strong></span> <span>of ADPKD with<br class="d-block d-md-none"> 712JYNARQUE<sup>®</sup> (tolvaptan)</span></h1> 713 714 </div> 715 </div> 716 717 718 719 720 721 722 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 723 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-2626" data-test='paragraph'> 724 725 726 727 728 729 730 731 732 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 733 <div class="field--item"> <div class="simple-text-option type-general type-a clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-1856" > 734 735 736 737 738 739 740 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 741 <div class="field--item"><p class="text-center text-md-left mb-md-3 pb-md-4">Talk to your nephrologist and learn how JYNARQUE is proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD.</p></div> 742 </div> 743 744 745 746 747 748 749 750 <div class="field field--name-field-link field--type-link field--label-hidden"> 751 <div class="field--item"><a href="why-jynarque.html">Why JYNARQUE?</a></div> 752 </div> 753 754 755 </div> 756</div> 757 <div class="field--item"> <div class="container footnote clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-1551" > 758 759 760 761 762 763 764 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 765 <div class="field--item"><p class="mb-md-3 pb-md-3">ADPKD=autosomal dominant polycystic kidney disease.</p></div> 766 </div> 767 768 769 </div> 770</div> 771 <div class="field--item"> <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-2621" > 772 773 </div> 774</div> 775 </div> 776 777 778 </div> 779</div> 780 <div class="field--item"> 781 782 783 <div class="clearfix hp-featured-group paragraph paragraph--type--homepage-feature-group paragraph--view-mode--default" id="paragraph-1681"> 784 785 786 787 788 789 790 <div class="field field--name-field-homepage-feature field--type-entity-reference-revisions field--label-hidden"> 791 <div class="field--item"> 792 793 <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1666" data-test='card'> 794 <div class="hp-featured__container"> 795 <div class="hp-featured__images"> 796 <h2 class="hp-featured__title"> How is your <strong>ADPKD <span>PROGRESSING?</span></strong> 797</h2> 798 <picture> 799 <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-desktop-3.jpg"/> 800 <img src="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-mobile.jpg" alt="" > 801 </picture> 802 <div class="hp-featured__disclaimer"> 803 804 805 806 807 808 <div class="field field--name-field-file-description field--type-string field--label-hidden"> 809 <div class="field--item">Patient image is AI-generated.</div> 810 </div> 811 812 </div> 813 </div> 814 <div class="hp-featured__content"> 815 <div class="container"> 816 <div class="hp-featured__content__contain"> 817 <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1666" aria-expanded="false" aria-controls="text-1666" data-analytics-name="toggle-button">
818 <span class="toggle-icon"></span> 819 </button> 820 <h2 class="hp-featured__title"> How is your <strong>ADPKD <span>PROGRESSING?</span></strong> 821</h2> 822 <div class="hp-featured__text"> 823 <div id="text-1666" class="d-md-block collapse"> 824 <p>ADPKD progression looks different for everyone. Do you know if you are at risk of rapidly progressing ADPKD or if your ADPKD is already rapidly progressing? It's important that you work with your nephrologist to understand your risk for rapid progression. The sooner you start, the sooner you can help take control of your ADPKD.</p> 825 </div> 826 <div class="hp-featured__link"> 827 <a href="understanding-adpkd-progression.html" class="button-primary">Learn about progression</a> 828 </div> 829 </div> 830 </div> 831 </div> 832 </div> 833 </div> 834 </div> 835 836</div> 837 <div class="field--item"> 838 839 <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1671" data-test='card'> 840 <div class="hp-featured__container"> 841 <div class="hp-featured__images"> 842 <h2 class="hp-featured__title"> Treating your <strong>ADPKD</strong> 843</h2> 844 <picture> 845 <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD.jpg"/> 846 <img src="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-mobile-0.jpg" alt="" > 847 </picture> 848 <div class="hp-featured__disclaimer"> 849 850 851 852 853 854 <div class="field field--name-field-file-description field--type-string field--label-hidden"> 855 <div class="field--item">Patient image is AI-generated.</div> 856 </div> 857 858 </div> 859 </div> 860 <div class="hp-featured__content"> 861 <div class="container"> 862 <div class="hp-featured__content__contain"> 863 <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1671" aria-expanded="false" aria-controls="text-1671" data-analytics-name="toggle-button"> 864 <span class="toggle-icon"></span> 865 </button> 866 <h2 class="hp-featured__title"> Treating your <strong>ADPKD</strong> 867</h2> 868 <div class="hp-featured__text"> 869 <div id="text-1671" class="d-md-block collapse"> 870 <p><span class="d-inline d-lg-block">For adults who are at risk of rapidly progressing ADPKD,</span> JYNARQUE is proven to slow the decline of kidney function.</p> 871 </div> 872 <div class="hp-featured__link"> 873 <a href="is-jynarque-for-you.html" class="button-primary">See if JYNARQUE is right for you</a> 874 </div> 875 </div> 876 </div> 877 </div> 878 </div> 879 </div> 880 </div> 881 882</div> 883 <div class="field--item"> 884 885 <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1676" data-test='card'> 886 <div class="hp-featured__container"> 887 <div class="hp-featured__images"> 888 <h2 class="hp-featured__title"> See if <strong>JYNARQUE IS RIGHT FOR YOU</strong> 889</h2> 890 <picture> 891 <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/JYNARQUEISRIGHTFORYOU.jpg"/> 892 <img src="sites/g/files/qhldwo12166/files/2025-10/JYNARQUEISRIGHTFORYOU-mobile.jpg" alt="" > 893 </picture> 894 <div class="hp-featured__disclaimer"> 895 896 897 898 899 900 <div class="field field--name-field-file-description field--type-string field--label-hidden"> 901 <div class="field--item">Patient image is AI-generated.</div> 902 </div> 903 904 </div> 905 </div> 906 <div class="hp-featured__content"> 907 <div class="container"> 908 <div class="hp-featured__content__contain"> 909 <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1676" aria-expanded="false" aria-controls="text-1676" data-analytics-name="toggle-button">
910 <span class="toggle-icon"></span> 911 </button> 912 <h2 class="hp-featured__title"> See if <strong>JYNARQUE IS RIGHT FOR YOU</strong> 913</h2> 914 <div class="hp-featured__text"> 915 <div id="text-1676" class="d-md-block collapse"> 916 <p>If you have autosomal dominant polycystic kidney disease (ADPKD) and are over the age of 18, see if you could be at risk for rapid progression. Answer a few questions to find out if you should ask your nephrologist about JYNARQUE.</p> 917 </div> 918 <div class="hp-featured__link"> 919 <a href="is-jynarque-for-you.html" class="button-primary">Take the quiz</a> 920 </div> 921 </div> 922 </div> 923 </div> 924 </div> 925 </div> 926 </div> 927 928</div> 929 <div class="field--item"> 930 931 <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-4691" data-test='card'> 932 <div class="hp-featured__container"> 933 <div class="hp-featured__images"> 934 <h2 class="hp-featured__title"> <strong>SAVE</strong> on your JYNARQUE 935</h2> 936 <picture> 937 <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/SaveOnYourJYNARQUE.jpg"/> 938 <img src="sites/g/files/qhldwo12166/files/2025-10/SaveOnYourJYNARQUE-mobile.jpg" alt="" > 939 </picture> 940 <div class="hp-featured__disclaimer"> 941 942 943 944 945 946 <div class="field field--name-field-file-description field--type-string field--label-hidden"> 947 <div class="field--item">Patient image is AI-generated.</div> 948 </div> 949 950 </div> 951 </div> 952 <div class="hp-featured__content"> 953 <div class="container"> 954 <div class="hp-featured__content__contain"> 955 <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-4691" aria-expanded="false" aria-controls="text-4691" data-analytics-name="toggle-button"> 956 <span class="toggle-icon"></span> 957 </button> 958 <h2 class="hp-featured__title"> <strong>SAVE</strong> on your JYNARQUE 959</h2> 960 <div class="hp-featured__text"> 961 <div id="text-4691" class="d-md-block collapse"> 962 <p>Eligible patients may pay as little as $0 per month.*</p> 963 </div> 964 <div class="hp-featured__link"> 965 <a href="copay-assistance.html" class="button-primary">Learn more about copay savings</a> 966 </div> 967 </div> 968 </div> 969 </div> 970 </div> 971 </div> 972 </div> 973 974</div> 975 </div> 976 977 978 </div> 979</div> 980 <div class="field--item"> <div class="container homepage-wrapper-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-1576" data-test='paragraph'> 981 982 983 984 985 986 987 988 989 <div class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden"> 990 <div class="field--item"> <div class="image-center-simple-text clearfix paragraph paragraph--type--image paragraph--view-mode--default" id="paragraph-1571" > 991 992 993 994 995 996 <p>Start slowing your disease progression with</p> 997 998 999 1000 1001 1002 <div> 1003 1004 1005 1006 1007 1008 1009 <picture> 1010 <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2021-02/JYNARQUE_Logo_RGB.png" type="image/webp" sizes="100vw" width="936" height="253"/> 1011 <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2021-02/JYNARQUE_Logo_RGB.png" type="image/png" sizes="100vw" width="936" height="253"/> 1012 <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2021-02/JYNARQUE_Logo_RGB.png" sizes="100vw" width="936" height="253" src="sites/g/files/qhldwo12166/files/styles/max_1440
1012x1440/public/2021-02/JYNARQUE-Logo-RGB.png" alt="JYNARQUE®, Logo" typeof="foaf:Image" class="img-fluid" /> 1013 1014 </picture> 1015 1016 1017 1018</div> 1019 1020 1021 </div> 1022</div> 1023 <div class="field--item"> <div class="container footnote clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-1566" > 1024 1025 1026 1027 1028 1029 1030 <div class="field field--name-field-text field--type-text-long field--label-hidden"> 1031 <div class="field--item"><p><sup class="hang">* </sup>For eligible commercially insured patients who are prescribed JYNARQUE<sup>®</sup>. Benefits may apply to copays, co-insurance, and pharmacy deductibles. Maximum annual benefit and other restrictions apply. Click below for full terms and conditions.</p></div> 1032 </div> 1033 1034 1035 </div> 1036</div> 1037 </div> 1038 1039 1040 </div> 1041</div> 1042 <div class="field--item"> <div class="container clearfix paragraph paragraph--type--block paragraph--view-mode--default" id="paragraph-5741" data-test='paragraph'> 1043 1044 1045 1046 1047 1048 1049 <div class="field field--name-field-block field--type-entity-reference field--label-hidden"> 1050 <div class="field--item"><div id="block-jynarque-hcc-2021-savingscardtermsandconditions" class="block-content-savings-card-terms-and-conditions block-content-basic block block-block-content block-block-content948204b2-fc74-4e39-8fdf-feded6f16861 block-savings-card-terms-and-conditions"> 1051 1052 1053 <div class="content"> 1054 1055 1056 1057 1058 1059 1060 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 1061 <div class="field--item"><button type="button" data-toggle="modal" data-target="#savings-card-terms-and-conditions">See Savings Card Terms and Conditions</button> 1062<div class="modal fade" id="savings-card-terms-and-conditions" tabindex="-1" aria-labelledby="exampleModalLabel" aria-hidden="true"> 1063 <div class="modal-dialog"> 1064 <div class="modal-content"> 1065 <div class="modal-header"> 1066 <button type="button" class="close" data-dismiss="modal" aria-label="Close"> 1067 <span class="visually-hidden" aria-hidden="true">Close</span> 1068 </button> 1069 <h2>Eligibility Requirements</h2> 1070 </div> 1071 <div class="modal-body"> 1072 <p><strong>Patients may be eligible for the Commercial Copay Savings Program for JYNARQUE if:</strong></p> 1073 <p>The patient is insured by commercial insurance and the prescription insurance coverage does not cover the full cost of the patientâs JYNARQUE prescription; AND</p> 1074 <ol> 1075 <li>The patient is not covered by a state or federal healthcare program, including but not limited to Medicare Part D, Medicaid (including Medicaid managed care), Medigap, Veterans Affairs (VA), or Department of Defense (DOD) or TRICARE programs; AND</li> 1076 <li>The patient is 18 years of age or older; AND</li> 1077 <li>The patient is a resident of the United States or Puerto Rico; AND</li> 1078 <li>The patient has a prescription consistent with FDA-approved product labeling</li> 1079 </ol> 1080 <h2>Commercial Copay Savings Program Terms & Conditions</h2> 1081 <ol> 1082 <li>Eligible patients who have an activated Member Number under the Commercial Copay Savings Program, together with a valid prescription for JYNARQUE, may pay as little as $0 per 28-day supply of JYNARQUE. Benefit amount is subject to (1) a monthly maximum based on typical insurance reimbursement rates, including maximum annual out-of-pocket limits established by the Affordability Care Act, and (2) a separate annual maximum benefit of the Affordable Care Act Maximum Out-of-pocket ($10,600 for 2026). These maximums are set and may be changed at Otsukaâs sole discretion. Maximum benefits and copay assistance redemption methods may vary as necessary to ensure compliance with these Terms and Conditions. Other restrictions may apply.</li> 1083 <li>Offer not applicable to copays of $0 or less.</li> 1084 <li>This offer is non-transferable, no substitutions are permissible, and this offer is intended solely for the patientâs benefit and cannot be combined with any other rebate/coupon, free trial, or other offer for the specified prescription (including any pharmacy benefit manager or insurer program that adju
1084sts patientsâ out-of-pocket costs for their drugs, such as through âmaximizersâ or âaccumulatorsâ).</li> 1085 <li>Eligible patients must enroll in the Commercial Copay Savings Program, without the help of any insurer, pharmacy benefit manager, or agent to these entities. Pharmacy-assisted enrollment is permitted.</li> 1086 <li>Patient agrees, if required by their insurer, to notify the insurer of their participation in the Co-pay Assistance Program.</li> 1087 <li>Otsuka reserves the right to rescind, revoke, or amend this offer at any time without notice and for any reason, including to ensure that the offer is used solely for the patientâs benefit.</li> 1088 <li><strong>The Commercial Copay Savings Program for JYNARQUE is not insurance and is not intended to substitute for insurance.</strong></li> 1089 <li>No purchase necessary, other than of the prescription for JYNARQUE for which assistance is provided under the Copay Savings Program. AND</li> 1090 <li>The Copay Savings Program is void where taxed, restricted, or prohibited by law or patientâs insurance plan. Beginning May 13, 2025, patients residing in Massachusetts are prohibited from accessing or using the Copay Savings Program, per applicable state laws. Beginning August 13, 2025, patients residing in California are prohibited from accessing or using the Copay Savings Program, per applicable state laws. Notwithstanding the foregoing, patients residing in California may, in accordance with California law, continue to access and use the Copay Savings Program if (i) the applicable patient has completed any applicable step therapy or prior authorization requirements for JYNARQUE, as mandated by the patientâs health insurer, health care service plan, or other health coverage, or (ii) a generic alternative is not available through the patientâs insurance coverage at a lower cost tier.</li> 1091 </ol> 1092 </div> 1093 </div> 1094 </div> 1095</div></div> 1096 </div> 1097 1098 1099 </div> 1100 </div> 1101</div> 1102 </div> 1103 1104 1105 </div> 1106</div> 1107 </div> 1108 1109 1110 </div> 1111 1112</article> 1113 1114 </div> 1115 </div> 1116 1117 </div> 1118 1119 </div> 1120 <div class="isi-page-wrapper"> 1121 <div class="container"> 1122 <div class="region region-isi clearfix"> 1123 1124 1125 1126 <a id="isi-top" name="isi-top"></a> 1127 <section id="inline-isi-wrapper" class="section isi-section" data-test="isi"> 1128 1129 <div class="isi isi-block"> 1130 <div class="isi-inline-title-wrap"><span class="isi-block-title">ISI Block Title 1131</span></div> 1132 1133 <div class="isi-inline-inner-wrap"><div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink
1133water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1â800â438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p> 1134</div> 1135 </div> 1136 1137 </section> 1138 1139 </div> 1140 1141 </div> 1142 </div> 1143 </main> 1144 1145 </div> 1146 1147 1148<footer id="section-footer" role="contentinfo"> 1149 <div id="footer"> 1150 <div class="container"> 1151 <div class="row"> 1152 <div class="col-12 col-lg-7 col-xl-8"> 1153 <div class="logo-footer"> 1154 <a href="https://www.otsuka-us.com/" target="_blank" data-test='navbar-branding' data-analytics-name="Otsuka Logo"> 1155 <img src="sites/g/files/qhldwo12166/themes/site/themes/custom/jynarque_hcc_2021/assets/build/img/otsuka-logo.png" alt="Otsuka, Logo"> 1156 </a> 1157 </div> 1158 <div class="footer-inline-items"> <div class="region region-footer-1 clearfix"> 1159 <div id="block-otsukacopyright" class="block block-otsuka-prc-code block-otsuka-copyright"> 1160 1161 1162 <div class="content" data-test='copyright'> 1163 © 2026 Otsuka America Pharmaceutical, Inc. 1164 </div> 1165 </div> 1166<div id="block-footerinlinetext" class="block-content-footer-inline-text block-content-basic block block-block-content block-block-content7f8acdb7-b4f7-4e3a-b947-0371f92fc130 block-footer-inline-text"> 1167 1168 1169 <div class="content"> 1170 1171 1172 1173 1174 1175 1176 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 1177 <div class="field--item"><p>All rights reserved.</p></div> 1178 </div> 1179 1180 1181 </div> 1182 </div> 1183<div id="block-jynarque-hcc-2021-prcdate" class="block block-otsuka-prc-code block-prc-code-date"> 1184 1185 1186 <div class="content" data-test='prc-date'> 1187 May 2026 1188 </div> 1189 </div> 1190<div id="block-jynarque-hcc-2021-prccode" class="block block-otsuka-prc-code block-prc-code"> 1191 1192 1193 <div class="content" data-test='prc-code'> 1194 10US26EBC0002 1195 </div> 1196 </div> 1197 1198 </div> 1199</div> 1200 </div> 1201 <div class="col-12 col-lg-5 col-xl-4"> 1202 <div class="region region-footer-2 clearfix"> 1203 <nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-footer-menu" id="block-jynarque-hcc-2021-footer"> 1204 1205 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-footer-menu">Footer menu</h2> 1206 1207 1208 1209 <ul data-block="block-jynarque-hcc-2021-footer" data-test="footer-menu" class="menu menu-footer nav"> 1210 <li class="menu-item menu-item-1 nav-item">
1211 <a href="https://www.otsuka-us.com/oapi-privacy-policy" target="_blank">Privacy Policy</a> 1212 </li> 1213 <li class="menu-item menu-item-2 nav-item"> 1214 <a href="https://www.otsuka-us.com/terms-and-conditions" target="_blank">Terms of Use</a> 1215 </li> 1216 <li class="menu-item menu-item-3 nav-item"> 1217 <a href="site-map.html" data-drupal-link-system-path="sitemap">Site Map</a> 1218 </li> 1219 </ul> 1220 1221 1222 1223 </nav> 1224<nav role="navigation" aria-labelledby="block-jynarque-hcc-2021-footerlogos-menu" id="block-jynarque-hcc-2021-footerlogos"> 1225 1226 <h2 class="visually-hidden" id="block-jynarque-hcc-2021-footerlogos-menu">footer logos</h2> 1227 1228 1229 1230 <ul data-block="block-jynarque-hcc-2021-footerlogos" data-test="social-menu" class="menu menu-footer-logos nav"> 1231 <li class="menu-item menu-item-1 nav-item"> 1232 <a href="https://www.facebook.com/JYNARQUE" target="_blank" class="facebook">Facebook</a> 1233 </li> 1234 <li class="menu-item menu-item-2 nav-item"> 1235 <a href="https://www.instagram.com/jynarque_tolvaptan/" target="_blank" class="instagram">Instagram</a> 1236 </li> 1237 <li class="menu-item menu-item-3 nav-item"> 1238 <a href="https://x.com/JYNARQUE" class="twitter" target="_blank">X</a> 1239 </li> 1240 </ul> 1241 1242 1243 1244 </nav> 1245 1246 </div> 1247 1248 </div> 1249 </div> 1250 </div> 1251 </div> 1252 </footer> 1253 1254 1255 <div class="region region-visually-hidden clearfix"> 1256 <div id="block-covidpopupblock" class="block-content-covid-popup-block block-content-basic block block-block-content block-block-content70c8b744-13e7-4ccb-b65f-37b04443e87e block-covid-popup-block"> 1257 1258 1259 <div class="content"> 1260 1261 1262 1263 1264 1265 1266 <div class="field field--name-body field--type-text-with-summary field--label-hidden"> 1267 <div class="field--item"><h2>COVID-19 UPDATE</h2> 1268 1269<p>With the COVID-19 situation constantly developing, your health is our top priority. We hope that you and your families are staying safe and healthy during this unprecedented time.</p> 1270 1271<p>If you are currently taking JYNARQUE<sup>®</sup> (tolvaptan), we encourage you to stay in close contact with your healthcare professional team regarding regular appointments and treatment management plans.</p> 1272 1273<p>At this time, there is no expected impact on medication supply.</p> 1274 1275<p>During the current COVID-19 <span class="text-nowrap">pandemic, the JYNARQUE<sup>®</sup> (tolvaptan)</span> REMS Program requirements remain in effect, as the health of patients who use this product is our top priority. Ongoing blood monitoring required by the REMS Program is extremely important due to the potential risk of serious liver injury from treatment with JYNARQUE. For these lab requirements during COVID-19 pandemic, we are able to temporarily offer our Mobile Phlebotomy Collection Service at no-cost for all patients taking JYNARQUE who prefer to have the REMS required blood work collected at home.</p> 1276 1277<p>In helping patients who have lost a job or health insurance coverage due to the COVID-19 pandemic and to get through these challenging times, we have extended our Patient Support Program to provide âno-costâ access for patients in the U.S. who are taking JYNARQUE. Please call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a> for more information on both programs.</p> 1278 1279<p>For help accessing JYNARQUE, go to <a class="cta_exit" href="https://www.otsukapatientsupport.com/jynarque" target="_blank">www.otsukapatientsupport.com/jynarque</a> or call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a>. The nurses at Otsuka Patient Support can answer questions related to Product Accessibility, Reimbursement and connecting patients to local treatment sites in their community.</p> 1280 1281<p>Please read <a class="dummy external-link-popup-disabled" href="https://www.otsuka-u
1281s.com/media/static/JYNARQUE-PI.pdf" target="_blank">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="dummy external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" target="_blank">MEDICATION GUIDE</a>.</p> 1282 1283<p class="covid-footnote"><span class="covid-prc-1">September 2020</span><span class="covid-prc-2">10US20EBC0103</span></p> 1284</div> 1285 </div> 1286 1287 1288 </div> 1289 </div> 1290 1291 </div> 1292 1293 1294 </div> 1295 1296 1297 1298 1299 1300 1301 1302 1303 1304<section id="drawer-isi" class="isi-tray jsIsiContainer isi-drawer-collapsed" aria-label="ISI"> 1305 1306 <!--<div id="isi-drawer-wrapper" class="isi-drawer-collapsed">--> 1307 1308 <div class="isi-header"> 1309 <div class="isi-header-wrap"> 1310 <div class="drawer-title">IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan) 1311</div> 1312 <button class="isi-btn jsIsiMinimize" data-oapigtmcategory="Button Clicks" data-oapigtmaction="ISI" data-oapigtmlabel="More +"><span class="jsSwapText jsSwapTextExpand">More +</span><span class="jsSwapText jsSwapTextCollapse hide">Less -</span><span class="isi-btn-icon"></span></button> 1313 </div> 1314 </div> 1315 1316 <div class="isi isi-block isi-drawer-content isi-content-wrap"> 1317 <div class="jcf-scrollable jcf-container mCustomScrollbar"> 1318 <div class="isi-drawer-content-heading">ISI Block Title 1319</div> 1320 <div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink
1320water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1â800â438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p> 1321 1322 </div> 1323 </div> 1324 1325 <!--</div>--><!--/#isi-drawer-wrapper--> 1326 1327</section> 1328<style> 1329 1330 .isi-tray { 1331 left: 0%; 1332 width: 100%; 1333 } 1334 .isi-drawer-expanded { 1335 height: 100px; 1336 } 1337 .isi-drawer-collapsed { 1338 height: 40px; 1339 } 1340 1341 .isi-tray.isi-drawer-expanded .isi-content-wrap, 1342 .isi-tray.isi-drawer-expanded .isi-content-wrap>div { 1343 height: calc(50vh - 220px); 1344 } 1345 @media all and (min-width: 768px) { 1346 .isi-tray.isi-drawer-expanded .isi-content-wrap, 1347 .isi-tray.isi-drawer-expanded .isi-content-wrap>div { 1348 height: calc(50vh - 60px); 1349 } 1350 } 1351</style> 1352 1353 1354
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