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https://www.jynarque.com/

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136"headline": ["Now is the time to push back the progression of ADPKD with JYNARQUE® (tolvaptan)","Treating your ADPKD","Connect with the ADPKD community","SAVE on your JYNARQUE"],
137"abstract": "For adults who are at risk for rapidly progressing ADPKD, JYNARQUE is the only FDA-approved treatment proven to work over a period of years to slow the decline of kidney function.",
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153"description": "In a Mayo Clinic ADPKD study that included 538 patients, 2 out of 3 people with ADPKD were at risk for rapid progression. It’s important that you work with your nephrologist to understand your risk for rapid progression.",
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160"name": "Learn more about copay savings",
161"description": "Eligible patients pay as little as $10 per month for a JYNARQUE prescription*",
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165"name": "autosomal dominant polycystic kidney disease",
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168"guideline": ["It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver: before you start taking JYNARQUE, at 2 weeks and 4 weeks after you start treatment with JYNARQUE, then monthly for 18 months during treatment with JYNARQUE, and every 3 months from then on","Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the JYNARQUE Risk Evaluation and Mitigation Strategy (REMS) Program.","Do not take JYNARQUE if you: have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease, cannot feel if you are thirsty or cannot replace fluids by drinking, have been told that the amount of sodium (salt) in your blood is too high or too low, are dehydrated, are allergic to tolvaptan or any of the ingredients in JYNARQUE, are unable to urinate"],
169"adverseOutcome": "The most common side effects of JYNARQUE are: thirst and increased fluid intake and making large amounts of urine, urinating often, and urinating at night",
170"seriousAdverseOutcome": "JYNARQUE may cause serious side effects, including: Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration). In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms: dizziness, fainting, weight loss, a change in the way your heart beats, feeling confused or weak",
171"contraindication": ["Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines. Do not start taking a new medicine without talking to your healthcare provider","Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood."],
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197"warning": "Please read FULL PRESCRIBING INFORMATION, including BOXED WARNING, and MEDICATION GUIDE.",
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202
203
204    <title>Rapidly Progressing ADPKD Treatment | JYNARQUE® (tolvaptan) tablets</title>
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458                  <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a>
459                      </li>
460                      <li class="menu-item menu-item-4 nav-item">
461                  <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a>
462                      </li>
463                      <li class="menu-item menu-item-5 nav-item">
464                  <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a>
465                      </li>
466        </ul>
467  
468              </li>
469                      <li class="menu-item menu-item-2 menu-item--expanded nav-item">
470                  <a href="#"><span>Getting Started</span></a>
471                                        <ul class="menu nav">
472                          <li class="menu-item menu-item-1 nav-item">
473                  <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a>
474                      </li>
475                      <li class="menu-item menu-item-2 nav-item">
476                  <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a>
477                      </li>
478                      <li class="menu-item menu-item-3 nav-item">
479                  <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a>
480                      </li>
481                      <li class="menu-item menu-item-4 nav-item">
482                  <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a>
483                      </li>
484        </ul>
485  
486              </li>
487                      <li class="menu-item menu-item-3 nav-item">
488                  <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a>
489                      </li>
490                      <li class="menu-item menu-item-4 menu-item--expanded nav-item">
491                  <a href="#"><span>Resources</span></a>
492                                        <ul class="menu nav">
493                          <li class="menu-item menu-item-1 nav-item">
494                  <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a>
495                      </li>
496                      <li class="menu-item menu-item-2 nav-item">
497                  <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a>
498                      </li>
499        </ul>
500  
501              </li>
502        </ul>
503  
504
505
506  </nav>
507
508    <a href="#" class="mobile-menu-open-btn" data-test='mobile-menu-toggle'>
509      <span>Mobile menu</span>
510    </a>
511    <a href="#" class="mobile-menu-close-btn">
512      <span>Mobile menu</span>
513    </a>
514  </div>
515
516        </div>
517      </div>
518      </header>
519
520  <div id="mobile-menu" class="region--mobile-menu" data-analytics-position="header">
521    <div class="container">
522        <div class="region region-mobile-menu clearfix">
523    <nav role="navigation" aria-labelledby="block-mainnavigation-menu" id="block-mainnavigation">
524            
525  <h2 class="visually-hidden" id="block-mainnavigation-menu">Main navigation</h2>
526  
527
528        
529              <ul data-block="block-mainnavigation" data-test="main-menu" class="menu menu-main nav">
530                          <li class="menu-item menu-item-1 menu-item--expanded nav-item">
531                  <a href="#"><span>About JYNARQUE</span></a>
532                                        <ul class="menu nav">
533                          <li class="menu-item menu-item-1 nav-item">
534                  <a href="understanding-adpkd-progression.html" data-drupal-link-system-path="node/37481">Understanding ADPKD & Progression</a>
535                      </li>
536                      <li class="menu-item menu-item-2 nav-item">
537                  <a href="why-jynarque.html" data-drupal-link-system-path="node/6">Why JYNARQUE?</a>
538                      </li>
539                      <li class="menu-item menu-item-3 nav-item">
540                  <a href="how-jynarque-works.html" data-drupal-link-system-path="node/26">How JYNARQUE Works</a>
541                      </li>
542                      <li class="menu-item menu-item-4 nav-item">
543                  <a href="side-effects-rems.html" data-drupal-link-system-path="node/25741">JYNARQUE Side Effects and REMS</a>
544                      </li>
545                      <li class="menu-item menu-item-5 nav-item">
546                  <a href="is-jynarque-for-you.html" data-drupal-link-system-path="node/25746">See if JYNARQUE is Right for You</a>
547                      </li>
548        </ul>
549  
550              </li>
551                      <li class="menu-item menu-item-2 menu-item--expanded nav-item">
552                  <a href="#"><span>Getting Started</span></a>
553                                        <ul class="menu nav">
554                          <li class="menu-item menu-item-1 nav-item">
555                  <a href="how-to-get-started.html" data-drupal-link-system-path="node/36">How to Get Started</a>
556                      </li>
557                      <li class="menu-item menu-item-2 nav-item">
558                  <a href="risks-and-rems.html" data-drupal-link-system-path="node/25736">REMS: Lab Work and Monitoring</a>
559                      </li>
560                      <li class="menu-item menu-item-3 nav-item">
561                  <a href="specialty-pharmacy.html" data-drupal-link-system-path="node/15816">Working With a Specialty Pharmacy</a>
562                      </li>
563                      <li class="menu-item menu-item-4 nav-item">
564                  <a href="how-to-take-jynarque.html" data-drupal-link-system-path="node/25726">How to Take JYNARQUE</a>
565                      </li>
566        </ul>
567  
568              </li>
569                      <li class="menu-item menu-item-3 nav-item">
570                  <a href="tips-while-on-treatment.html" data-drupal-link-system-path="node/31">Tips While on Treatment</a>
571                      </li>
572                      <li class="menu-item menu-item-4 menu-item--expanded nav-item">
573                  <a href="#"><span>Resources</span></a>
574                                        <ul class="menu nav">
575                          <li class="menu-item menu-item-1 nav-item">
576                  <a href="online-resources.html" data-drupal-link-system-path="node/25831">Online Resources</a>
577                      </li>
578                      <li class="menu-item menu-item-2 nav-item">
579                  <a href="downloadable-resources.html" data-drupal-link-system-path="node/25721">Downloadable Resources</a>
580                      </li>
581        </ul>
582  
583              </li>
584        </ul>
585  
586
587
588  </nav>
589
590  </div>
591
592    </div>
593  </div>
594  <section aria-label="Header Information">
595    <div id="header-info" class="region--header-info">
596      <div class="container">
597          <div class="region region-header-info clearfix">
598    <div id="block-jynarque-hcc-2021-headertextdescription" class="block-content-header-text-description block-content-basic block block-block-content block-block-content855941ea-329b-4a19-bc10-2bd1df83da5c block-header-text-description">
599  
600    
601      <div class="content">
602      
603
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605
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607  
608                        <div  class="field field--name-body field--type-text-with-summary field--label-hidden">
609                          <div class="field--item"><p>Proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD</p></div>
610                      </div>
611              
612  
613    </div>
614  </div>
615
616  </div>
617
618      </div>
619    </div>
620  </section>
621
622
623    <main role="main" class="main-content" id="main-content">
624                    <div class="container">
625            <div class="region region-highlighted clearfix">
626    <div data-drupal-messages-fallback class="hidden"></div>
627
628  </div>
629
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631                    <div class="no-sidebar">
632            <div class="region region-content clearfix">
633    <div id="block-jynarque-hcc-2021-content" class="block block-system block-system-main-block">
634  
635    
636      <div class="content">
637      
638
639<article data-history-node-id="1" about="/node/1" class="node node-type-landing-page node--promoted node-view-mode-full">
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641  
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645            <div class="hero-section">
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652                        <div  class="field field--name-field-hero-media-mobile field--type-entity-reference field--label-hidden">
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660                  <picture>
661                  <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" type="image/webp" sizes="100vw" width="720" height="170"/>
662              <source srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" type="image/jpeg" sizes="100vw" width="720" height="170"/>
663                  <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" sizes="100vw" width="720" height="170" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1-mobile.jpg" alt="" typeof="foaf:Image" class="img-fluid" />
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689                  <source srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" type="image/webp" sizes="100vw" width="2600" height="605"/>
690              <source srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" type="image/jpeg" sizes="100vw" width="2600" height="605"/>
691                  <img loading="eager" srcset="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg, sites/g/files/qhldwo12166/files/styles/max_2600x2600/public/2025-10/OTSU_A070547_4C_v3_1.jpg" sizes="100vw" width="1440" height="335" src="sites/g/files/qhldwo12166/files/styles/max_1440x1440/public/2025-10/OTSU_A070547_4C_v3_1.jpg" alt="" typeof="foaf:Image" class="img-fluid" />
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693  </picture>
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695
696      
697</div>
698</div>
699                      </div>
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702      </div>
703    
704    <div class="node-content">
705      
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709<div  class="field field--name-field-formatted-title field--type-text-long field--label-hidden container" data-test='paragraph'>
710      <div class="field--item">
711      <h1><span>Now is the time to</span> <span><strong>PUSH BACK THE PROGRESSION</strong></span> <span>of ADPKD with<br class="d-block d-md-none">
712JYNARQUE<sup>®</sup> (tolvaptan)</span></h1>
713
714    </div>
715  </div>
716
717
718
719
720
721  
722                        <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
723                          <div class="field--item">  <div class="container clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-2626" data-test='paragraph'>
724                            
725
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730  
731    
732                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
733                              <div class="field--item">  <div class="simple-text-option type-general type-a clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-1856" >
734          
735
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739  
740                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
741                          <div class="field--item"><p class="text-center text-md-left mb-md-3 pb-md-4">Talk to your nephrologist and learn how JYNARQUE is proven to slow kidney function decline in adults who are at risk for rapidly progressing ADPKD.</p></div>
742                      </div>
743              
744  
745
746
747
748
749  
750                        <div  class="field field--name-field-link field--type-link field--label-hidden">
751                          <div class="field--item"><a href="why-jynarque.html">Why JYNARQUE?</a></div>
752                      </div>
753              
754  
755      </div>
756</div>
757                              <div class="field--item">  <div class="container footnote clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-1551" >
758          
759
760
761
762
763  
764                        <div  class="field field--name-field-text field--type-text-long field--label-hidden">
765                          <div class="field--item"><p class="mb-md-3 pb-md-3">ADPKD=autosomal dominant polycystic kidney disease.</p></div>
766                      </div>
767              
768  
769      </div>
770</div>
771                              <div class="field--item">  <div class="clearfix paragraph paragraph--type--text paragraph--view-mode--default" id="paragraph-2621" >
772          
773      </div>
774</div>
775                          </div>
776                  
777      
778                    </div>
779</div>
780                          <div class="field--item">
781
782
783  <div class="clearfix hp-featured-group paragraph paragraph--type--homepage-feature-group paragraph--view-mode--default" id="paragraph-1681">
784        
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788
789  
790                        <div  class="field field--name-field-homepage-feature field--type-entity-reference-revisions field--label-hidden">
791                          <div class="field--item">
792
793  <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1666" data-test='card'>
794    <div class="hp-featured__container">
795          <div class="hp-featured__images">
796        <h2 class="hp-featured__title">  How is your <strong>ADPKD <span>PROGRESSING?</span></strong>
797</h2>
798                  <picture>
799            <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-desktop-3.jpg"/>
800            <img src="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-mobile.jpg" alt="" >
801          </picture>
802                <div class="hp-featured__disclaimer">
803
804
805
806
807  
808                        <div  class="field field--name-field-file-description field--type-string field--label-hidden">
809                          <div class="field--item">Patient image is AI-generated.</div>
810                      </div>
811              
812  </div>
813      </div>
814      <div class="hp-featured__content">
815        <div class="container">
816          <div class="hp-featured__content__contain">
817            <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1666" aria-expanded="false" aria-controls="text-1666" data-analytics-name="toggle-button">
818              <span class="toggle-icon"></span>
819            </button>
820            <h2 class="hp-featured__title">  How is your <strong>ADPKD <span>PROGRESSING?</span></strong>
821</h2>
822            <div class="hp-featured__text">
823            <div id="text-1666" class="d-md-block collapse">
824              <p>ADPKD progression looks different for everyone. Do you know if you are at risk of rapidly progressing ADPKD or if your ADPKD is already rapidly progressing? It's important that you work with your nephrologist to understand your risk for rapid progression. The sooner you start, the sooner you can help take control of your ADPKD.</p>
825            </div>
826                              <div class="hp-featured__link">
827                  <a href="understanding-adpkd-progression.html" class="button-primary">Learn about progression</a>
828                </div>
829                          </div>
830          </div>
831        </div>
832      </div>
833        </div>
834  </div>
835
836</div>
837                          <div class="field--item">
838
839  <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1671" data-test='card'>
840    <div class="hp-featured__container">
841          <div class="hp-featured__images">
842        <h2 class="hp-featured__title">  Treating your <strong>ADPKD</strong>
843</h2>
844                  <picture>
845            <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD.jpg"/>
846            <img src="sites/g/files/qhldwo12166/files/2025-10/TreatingYourADPKD-mobile-0.jpg" alt="" >
847          </picture>
848                <div class="hp-featured__disclaimer">
849
850
851
852
853  
854                        <div  class="field field--name-field-file-description field--type-string field--label-hidden">
855                          <div class="field--item">Patient image is AI-generated.</div>
856                      </div>
857              
858  </div>
859      </div>
860      <div class="hp-featured__content">
861        <div class="container">
862          <div class="hp-featured__content__contain">
863            <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1671" aria-expanded="false" aria-controls="text-1671" data-analytics-name="toggle-button">
864              <span class="toggle-icon"></span>
865            </button>
866            <h2 class="hp-featured__title">  Treating your <strong>ADPKD</strong>
867</h2>
868            <div class="hp-featured__text">
869            <div id="text-1671" class="d-md-block collapse">
870              <p><span class="d-inline d-lg-block">For adults who are at risk of rapidly progressing ADPKD,</span> JYNARQUE is proven to slow the decline of kidney function.</p>
871            </div>
872                              <div class="hp-featured__link">
873                  <a href="is-jynarque-for-you.html" class="button-primary">See if JYNARQUE is right for you</a>
874                </div>
875                          </div>
876          </div>
877        </div>
878      </div>
879        </div>
880  </div>
881
882</div>
883                          <div class="field--item">
884
885  <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-1676" data-test='card'>
886    <div class="hp-featured__container">
887          <div class="hp-featured__images">
888        <h2 class="hp-featured__title">  See if <strong>JYNARQUE IS RIGHT FOR YOU</strong>
889</h2>
890                  <picture>
891            <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/JYNARQUEISRIGHTFORYOU.jpg"/>
892            <img src="sites/g/files/qhldwo12166/files/2025-10/JYNARQUEISRIGHTFORYOU-mobile.jpg" alt="" >
893          </picture>
894                <div class="hp-featured__disclaimer">
895
896
897
898
899  
900                        <div  class="field field--name-field-file-description field--type-string field--label-hidden">
901                          <div class="field--item">Patient image is AI-generated.</div>
902                      </div>
903              
904  </div>
905      </div>
906      <div class="hp-featured__content">
907        <div class="container">
908          <div class="hp-featured__content__contain">
909            <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-1676" aria-expanded="false" aria-controls="text-1676" data-analytics-name="toggle-button">
910              <span class="toggle-icon"></span>
911            </button>
912            <h2 class="hp-featured__title">  See if <strong>JYNARQUE IS RIGHT FOR YOU</strong>
913</h2>
914            <div class="hp-featured__text">
915            <div id="text-1676" class="d-md-block collapse">
916              <p>If you have autosomal dominant polycystic kidney disease (ADPKD) and are over the age of 18, see if you could be at risk for rapid progression. Answer a few questions to find out if you should ask your nephrologist about JYNARQUE.</p>
917            </div>
918                              <div class="hp-featured__link">
919                  <a href="is-jynarque-for-you.html" class="button-primary">Take the quiz</a>
920                </div>
921                          </div>
922          </div>
923        </div>
924      </div>
925        </div>
926  </div>
927
928</div>
929                          <div class="field--item">
930
931  <div class="clearfix hp-featured paragraph paragraph--type--homepage-feature paragraph--view-mode--default" id="paragraph-4691" data-test='card'>
932    <div class="hp-featured__container">
933          <div class="hp-featured__images">
934        <h2 class="hp-featured__title">  <strong>SAVE</strong> on your JYNARQUE
935</h2>
936                  <picture>
937            <source media="(min-width: 960px)" srcset="sites/g/files/qhldwo12166/files/2025-10/SaveOnYourJYNARQUE.jpg"/>
938            <img src="sites/g/files/qhldwo12166/files/2025-10/SaveOnYourJYNARQUE-mobile.jpg" alt="" >
939          </picture>
940                <div class="hp-featured__disclaimer">
941
942
943
944
945  
946                        <div  class="field field--name-field-file-description field--type-string field--label-hidden">
947                          <div class="field--item">Patient image is AI-generated.</div>
948                      </div>
949              
950  </div>
951      </div>
952      <div class="hp-featured__content">
953        <div class="container">
954          <div class="hp-featured__content__contain">
955            <button class="d-md-none btn toggle-button collapsed" data-toggle="collapse" data-target="#text-4691" aria-expanded="false" aria-controls="text-4691" data-analytics-name="toggle-button">
956              <span class="toggle-icon"></span>
957            </button>
958            <h2 class="hp-featured__title">  <strong>SAVE</strong> on your JYNARQUE
959</h2>
960            <div class="hp-featured__text">
961            <div id="text-4691" class="d-md-block collapse">
962              <p>Eligible patients may pay as little as $0 per month.*</p>
963            </div>
964                              <div class="hp-featured__link">
965                  <a href="copay-assistance.html" class="button-primary">Learn more about copay savings</a>
966                </div>
967                          </div>
968          </div>
969        </div>
970      </div>
971        </div>
972  </div>
973
974</div>
975                      </div>
976              
977  
978      </div>
979</div>
980                          <div class="field--item">  <div class="container homepage-wrapper-c clearfix paragraph paragraph--type--wrapper paragraph--view-mode--default" id="paragraph-1576" data-test='paragraph'>
981                            
982
983
984
985
986
987  
988    
989                              <div  class="field field--name-field-paragraphs field--type-entity-reference-revisions field--label-hidden">
990                              <div class="field--item">  <div class="image-center-simple-text clearfix paragraph paragraph--type--image paragraph--view-mode--default" id="paragraph-1571" >
991          
992
993
994
995
996              <p>Start slowing your disease progression with</p>
997      
998
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1031                          <div class="field--item"><p><sup class="hang">* </sup>For eligible commercially insured patients who are prescribed JYNARQUE<sup>®</sup>. Benefits may apply to copays, co-insurance, and pharmacy deductibles. Maximum annual benefit and other restrictions apply. Click below for full terms and conditions.</p></div>
1032                      </div>
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1069        <h2>Eligibility Requirements</h2>
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1071      <div class="modal-body">
1072        <p><strong>Patients may be eligible for the Commercial Copay Savings Program for JYNARQUE if:</strong></p>
1073        <p>The patient is insured by commercial insurance and the prescription insurance coverage does not cover the full cost of the patient’s JYNARQUE prescription; AND</p>
1074        <ol>
1075            <li>The patient is not covered by a state or federal healthcare program, including but not limited to Medicare Part D, Medicaid (including Medicaid managed care), Medigap, Veterans Affairs (VA), or Department of Defense (DOD) or TRICARE programs; AND</li>
1076            <li>The patient is 18 years of age or older; AND</li>
1077            <li>The patient is a resident of the United States or Puerto Rico; AND</li>
1078            <li>The patient has a prescription consistent with FDA-approved product labeling</li>
1079        </ol> 
1080        <h2>Commercial Copay Savings Program Terms & Conditions</h2>
1081        <ol>
1082            <li>Eligible patients who have an activated Member Number under the Commercial Copay Savings Program, together with a valid prescription for JYNARQUE, may pay as little as $0 per 28-day supply of JYNARQUE. Benefit amount is subject to (1) a monthly maximum based on typical insurance reimbursement rates, including maximum annual out-of-pocket limits established by the Affordability Care Act, and (2) a separate annual maximum benefit of the Affordable Care Act Maximum Out-of-pocket ($10,600 for 2026). These maximums are set and may be changed at Otsuka’s sole discretion. Maximum benefits and copay assistance redemption methods may vary as necessary to ensure compliance with these Terms and Conditions. Other restrictions may apply.</li>
1083            <li>Offer not applicable to copays of $0 or less.</li>
1084            <li>This offer is non-transferable, no substitutions are permissible, and this offer is intended solely for the patient’s benefit and cannot be combined with any other rebate/coupon, free trial, or other offer for the specified prescription (including any pharmacy benefit manager or insurer program that adju
1084sts patients’ out-of-pocket costs for their drugs, such as through “maximizers” or “accumulators”).</li>
1085            <li>Eligible patients must enroll in the Commercial Copay Savings Program, without the help of any insurer, pharmacy benefit manager, or agent to these entities. Pharmacy-assisted enrollment is permitted.</li>
1086            <li>Patient agrees, if required by their insurer, to notify the insurer of their participation in the Co-pay Assistance Program.</li>
1087            <li>Otsuka reserves the right to rescind, revoke, or amend this offer at any time without notice and for any reason, including to ensure that the offer is used solely for the patient’s benefit.</li>
1088            <li><strong>The Commercial Copay Savings Program for JYNARQUE is not insurance and is not intended to substitute for insurance.</strong></li>
1089            <li>No purchase necessary, other than of the prescription for JYNARQUE for which assistance is provided under the Copay Savings Program. AND</li>
1090            <li>The Copay Savings Program is void where taxed, restricted, or prohibited by law or patient’s insurance plan.  Beginning May 13, 2025, patients residing in Massachusetts are prohibited from accessing or using the Copay Savings Program, per applicable state laws. Beginning August 13, 2025, patients residing in California are prohibited from accessing or using the Copay Savings Program, per applicable state laws. Notwithstanding the foregoing, patients residing in California may, in accordance with California law, continue to access and use the Copay Savings Program if (i) the applicable patient has completed any applicable step therapy or prior authorization requirements for JYNARQUE, as mandated by the patient’s health insurer, health care service plan, or other health coverage, or (ii) a generic alternative is not available through the patient’s insurance coverage at a lower cost tier.</li>
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1133      <div class="isi-inline-inner-wrap"><div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1133water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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1269<p>With the COVID-19 situation constantly developing, your health is our top priority. We hope that you and your families are staying safe and healthy during this unprecedented time.</p>
1270
1271<p>If you are currently taking JYNARQUE<sup>®</sup> (tolvaptan), we encourage you to stay in close contact with your healthcare professional team regarding regular appointments and treatment management plans.</p>
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1274
1275<p>During the current COVID-19 <span class="text-nowrap">pandemic, the JYNARQUE<sup>®</sup> (tolvaptan)</span> REMS Program requirements remain in effect, as the health of patients who use this product is our top priority. Ongoing blood monitoring required by the REMS Program is extremely important due to the potential risk of serious liver injury from treatment with JYNARQUE. For these lab requirements during COVID-19 pandemic, we are able to temporarily offer our Mobile Phlebotomy Collection Service at no-cost for all patients taking JYNARQUE who prefer to have the REMS required blood work collected at home.</p>
1276
1277<p>In helping patients who have lost a job or health insurance coverage due to the COVID-19 pandemic and to get through these challenging times, we have extended our Patient Support Program to provide ‘no-cost’ access for patients in the U.S. who are taking JYNARQUE. Please call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a> for more information on both programs.</p>
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1279<p>For help accessing JYNARQUE, go to <a class="cta_exit" href="https://www.otsukapatientsupport.com/jynarque" target="_blank">www.otsukapatientsupport.com/jynarque</a> or call Otsuka Patient Support at <a class="cta_phone" href="tel:1-855-242-7787">1-855-242-7787</a>. The nurses at Otsuka Patient Support can answer questions related to Product Accessibility, Reimbursement and connecting patients to local treatment sites in their community.</p>
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1281<p>Please read <a class="dummy external-link-popup-disabled" href="https://www.otsuka-u
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1310            <div class="drawer-title">IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)
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1320          <div class="isi-content-block"><h3>IMPORTANT SAFETY INFORMATION and INDICATION for JYNARQUE<sup>®</sup> (tolvaptan)</h3><ul class="list-style-dash"><li><strong>Serious liver problems.</strong> JYNARQUE can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. Stop taking JYNARQUE and call your healthcare provider right away if you get any of the following symptoms:<ul><li>feeling tired</li><li>loss of appetite</li><li>nausea</li><li>right upper stomach (abdomen) pain or tenderness</li><li>vomiting</li><li>fever</li><li>rash</li><li>itching</li><li>yellowing of the skin and white part of the eye (jaundice)</li><li>dark urine</li></ul></li></ul><p><strong>It is important that you have a blood test before you start JYNARQUE to help reduce your risk of liver problems. Your healthcare provider will do a blood test to check your liver:</strong></p><ul><li><strong>before you start taking JYNARQUE</strong></li><li><strong>at 2 weeks and 4 weeks after you start treatment with JYNARQUE</strong></li><li><strong>then monthly for 18 months during treatment with JYNARQUE</strong></li><li><strong>and every 3 months from then on</strong></li></ul><p><strong>Because of the risk of serious liver problems, JYNARQUE is only available through a restricted distribution program called the Tolvaptan for ADPKD Shared System Risk Evaluation and Mitigation Strategy (REMS).</strong></p><p><strong>Do not take JYNARQUE if you:</strong></p><ul><li>have a history of liver problems or have signs or symptoms of liver problems, excluding polycystic liver disease</li><li>cannot feel if you are thirsty or cannot replace fluids by drinking</li><li>have been told that the amount of sodium (salt) in your blood is too high or too low</li><li>are dehydrated</li><li>are allergic to tolvaptan or any of the ingredients in JYNARQUE</li><li>are unable to urinate</li></ul><p><strong>Tell your healthcare provider about all your medical conditions, including if you:</strong></p><ul><li>have a history of sodium (salt) levels that are too low</li><li>are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant</li><li>are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time</li></ul><p><strong>Tell your healthcare provider about all the medicines you take,</strong> including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.</p><ul><li>Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines</li><li>Do not start taking a new medicine without talking to your healthcare provider</li></ul><p><strong>JYNARQUE may cause serious side effects, including:</strong></p><ul><li><strong>Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration).</strong> In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink 
1320water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:<ul><li>dizziness</li><li>fainting</li><li>weight loss</li><li>a change in the way your heart beats</li><li>feeling confused or weak</li></ul></li></ul><p><strong>What should you avoid while taking JYNARQUE?</strong></p><p>Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much tolvaptan in your blood.</p><p>The <strong>most common side effects</strong> of JYNARQUE are:</p><ul><li>thirst and increased fluid intake</li><li>making large amounts of urine, urinating often, and urinating at night</li></ul><p>These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away. For more information, ask your healthcare provider or pharmacist.</p><p><strong>If you have any questions about your health or medicines, talk to your healthcare professional.</strong></p><p>To report SUSPECTED ADVERSE REACTIONS, contact Otsuka America Pharmaceutical, Inc. at 1‑800‑438-9927 or FDA at 1-800-FDA-1088 (<a href="https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program">www.fda.gov/medwatch</a>).</p></div><div class="isi-content-block"><h3>INDICATION:</h3><p><strong>What is JYNARQUE?</strong></p><p>JYNARQUE is a prescription medicine used to slow kidney function decline in adults who are at risk for rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It is not known if JYNARQUE is safe and effective in children.</p></div><p>Please read <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-PI.pdf" aria-label="FULL PRESCRIBING INFORMATION, Download PDF">FULL PRESCRIBING INFORMATION</a>, including <strong>BOXED WARNING</strong>, and <a class="external-link-popup-disabled" href="https://www.otsuka-us.com/media/static/JYNARQUE-Medguide.pdf" aria-label="MEDICATION GUIDE, Download PDF">MEDICATION GUIDE</a>.</p>
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