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Real world results.â¢</p> 280 </div> 281 </div> 282 <img alt="933143" class="ew-media" src="https://www.ossdsign.com/upl/images/933948/933143_1900_0_1_thumb.webp?t=755623800" /> 283</section> 284 285<section class="text-section m-standard"> 286 <div class="content-standard"> 287 <div class="text-block-xl"> 288 <span class="title slide-from-bottom" data-inviewanimation>Bone healing is not a single event</span> 289 290 291 </div> 292 <div class="text-columns"> 293 294 <div class="ew-html slide-from-bottom" data-inviewanimation> 295 <div><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Successful outcomes depend on early, rapid bone formation as well as continued maturation and remodeling to form stable, integrated bone.</h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">That understanding is reflected in the design of OssDsign Catalyst®, engineered to support healing across the full bone healing cascade from formation through remodeling.<sup>1,2</sup></h5></div> 296 </div> 297 298 </div> 299 300 </div> 301</section> 302<section class="text-media-section m-standard"> 303 <div class="content-standard"> 304 <div class="text-media row direction-row-reverse reversed"> 305 <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z row justify-end"> 306 <figure class="media-content" data-inviewanimation> 307 <img alt="1029x685px_grey_blurbackground_textleft" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268625/1029x685px-grey-blurbackground-textleft_1060_550_2_thumb.webp?t=833886360" /> 308 </figure> 309 </div> 310 <div class="col-10 col-mdtablet-24 column justify-end"> 311 <div class="text-content slide-from-bottom" data-inviewanimation> 312 <h2 class="title">OssDsign Catalyst</h2> 313 <div><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">A nanosynthetic, silicate-substituted bone graft designed to upregulate cellular BMP-2, drive dual-pathway healing, including endochondral ossification, and cell-mediated coupled remodeling, enabling rapid, robust fusion in challenging environments.<sup>1,2*</sup></p></div> 314 <a class="btn btn-primary m-t-3" href="/clinical-evidence" target="_blank">View the evidence<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> 315 <g clip-path="url(#clip0_30_108)"> 316 <path d="M4.45753 12.0001H19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 317 <path d="M12 4.45758L19.5425 12.0001L12 19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 318 </g> 319 <defs> 320 <clipPath id="clip0_30_108"> 321 <rect width="16" height="16" fill="white" transform="translate(12 0.68634) rotate(45)" /> 322 </clipPath> 323 </defs> 324</svg> 325</a> 326 </div> 327 </div> 328 </div> 329 </div> 330</section> 331<section class="text-section m-standard"> 332 <div class="content-standard"> 333 <div class="text-block-xl"> 334 335 336 337 </div> 338 339 <div class="row m-t-4 m-xlphone-t-2 slide-from-bottom" data-inviewanimation> 340 341 <a class="btn btn-primary" href="/contact" target="_blank">Request a demonstration<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> 342 <g clip-path="url(#clip0_30_108)"> 343 <path d="M4.45753 12.0001H19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 344 <path d="M12 4.45758L19.5425 12.0001L12 19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 345 </g> 346 <defs> 347 <clipPath id="clip0_30_108"> 348 <rect width="16" height="16" fill="white" transform="translate(12 0.68634) rotate(45)" /> 349 </clipPath> 350 </defs> 351</svg> 352</a> 353 354 <a class="btn btn-secondary" href="/surgeon-testimonials" target="_blank">Hear what surgeons are saying<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> 355 <g clip-path="url(#clip0_30_108)"> 356 <path d="M4.45753 12.0001H19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 357 <path d="M12 4.45758L19.5425 12.0001L12 19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 358 </g> 359 <defs> 360 <clipPath id="clip0_30_108"> 361 <rect width="16" height="16" fill="white" transform="translate(12 0.68634) rotate(45)" /> 362 </clipPath> 363 </defs> 364</svg> 365</a> 366 367 </div> 368 </div> 369</section> 370 371<section class="m-standard" id=""> 372 <div class="content-standard"> 373 374 <div class="media-grid"> 375 376 <div class="media-row"> 377 378 <figure class="slide-from-bottom" data-inviewanimation> 379 <img src="https://www.ossdsign.com/upl/images/1272541/catalyst-moa-graphic-website-4_1600_0_2_thumb.webp?t=835441860" style="width: 500px; height: 400px;" alt="Catalyst MOA Graphic_website_4" /> 380 381 </figure> 382 383 </div> 384 385 </div> 386 </div> 387</section><section class="text-media-section m-standard"> 388 <div class="content-standard"> 389 <div class="text-media row direction-row-reverse reversed"> 390 <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z row justify-end"> 391 <figure class="media-content" data-inviewanimation> 392 <img alt="1029x685px_beige_blurbackground_textright" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268622/1029x685px-beige-blurbackground-textright_1060_550_2_thumb.webp?t=833886300" /> 393 </figure> 394 </div> 395 <div class="col-10 col-mdtablet-24 column justify-end"> 396 <div class="text-content slide-from-bottom" data-inviewanimation> 397 <h2 class="title">Bone formation starts with cellular signaling</h2> 398 <div><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><u>Cellular BMP-2 upregulation</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Silicate ions are substituted directly into Catalystâs core chemistry, rather than coated on the surface or delivered via a carrier, enabling sustained silicate signaling from early healing through remodeling. Its high surface area mirrors native bone at the nanoscale, extending throughout the graft.<sup>1,2â </sup> Together, these features are designed to stimulate cellular BMP-2 activity, driving rapid bone formation.<sup>*â </sup></p></div> 399 400 </div> 401 </div> 402 </div> 403 </div> 404</section><section class="text-media-section m-standard"> 405 <div class="content-standard"> 406 <div class="text-media row "> 407 <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z "> 408 <figure class="media-content" data-inviewanimation> 409 <img alt="1029x685px_blue_blurbackground_textleft" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268623/1029x685px-blue-blurbackground-textleft_1060_550_2_thumb.webp?t=833886300" /> 410 </figure> 411 </div> 412 <div class="col-10 col-mdtablet-24 column justify-end"> 413 <div class="text-content slide-from-bottom" data-inviewanimation> 414 <h2 class="title">Cellular signaling drives how bone forms</h2> 415 <div><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></p><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><u>Dual-pathway healing</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Similar to rhBMP-2 and autograft, Catalyst activates endochondral ossification, the bodyâs primary fracture repair mechanism. Most synthetics rely solely on intramembranous bone formation. This facilitates fusion even in challenging avascular environments, such as the center of the fusion mass or large defects.<sup>2â </sup> By leveraging both pathways, Catalyst is designed to support bone formation in complex clinical scenarios.<sup>1,2â </sup></p></div> 416 417 </div> 418 </div> 419 </div> 420 </div> 421</section><section class="text-media-section m-standard"> 422 <div class="content-standard"> 423 <div class="text-media row direction-row-reverse reversed"> 424 <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z row justify-end"> 425 <figure class="media-content" data-inviewanimation> 426 <img alt="1029x685px_pink_blurbackground_textright" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268628/1029x685px-pink-blurbackground-textright_1060_550_2_thumb.webp?t=833886360" /> 427 </figure> 428 </div> 429 <div class="col-10 col-mdtablet-24 column justify-end"> 430 <div class="text-content slide-from-bottom" data-inviewanimation> 431 <h2 class="title">Bone formation starts the process â remodeling completes it</h2> 432 <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><br></p><h5 style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><u>Cell-mediated coupled remodeling</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"> In clinically relevant, challenging preclinical models, Catalyst has demonstrated coupled remodeling as early as 6 weeks. Catalyst is replaced by new bone, reflecting cell-mediated active healing. The result is functional, robust bone that integrates with native bone.<sup>1,2â </sup></p></div> 433 434 </div> 435 </div> 436 </div> 437 </div> 438</section> 439<section class="text-section m-standard"> 440 <div class="content-standard"> 441 <div class="text-block-xl">
442 <span class="title slide-from-bottom" data-inviewanimation>First class handling</span> 443 444 445 </div> 446 <div class="text-columns"> 447 448 <div class="ew-html slide-from-bottom" data-inviewanimation> 449 <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Available for immediate use</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Easy intra-operative manipulation</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Mixes well 1:1 with local autograft</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Packs well into an interbody cage</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Pushes easily down a canula</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">â Cleared for standalone use in the extremities</p></div> 450 </div> 451 452 </div> 453 454 </div> 455</section> 456 457<section class="text-section m-standard"> 458 <div class="content-standard"> 459 <div class="text-block-xl"> 460 461 462 463 </div> 464 <div class="text-columns"> 465 466 <div class="ew-html slide-from-bottom" data-inviewanimation> 467 <div><table style="width: 100%;"><tbody><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);"><strong>Article number</strong><br></td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);"><strong>Description</strong><br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);"><strong>Size</strong><br></td></tr><tr><td style="width: 20.2285%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">104010</td><td style="width: 62.6635%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">1 cc</td></tr><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);">104025</td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);">2.5 cc</td></tr><tr><td style="width: 20.2285%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">104050</td><td style="width: 62.6635%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">5 cc</td></tr><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);">104100</td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);">10 cc</td></tr></tbody></table><p><br></p></div> 468 </div> 469 470 </div> 471 <div class="row m-t-4 m-xlphone-t-2 slide-from-bottom" data-inviewanimation> 472 473 <a class="btn btn-primary" href="https://www.ossdsign.com/upl/files/257062/2021-2225-ossdsign-catalyst-ifu-rev04-original-layout.pdf?t=827244180" target="_blank">Download the OssDsign Catalyst IFU<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> 474 <g clip-path="url(#clip0_30_108)"> 475 <path d="M4.45753 12.0001H19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 476 <path d="M12 4.45758L19.5425 12.0001L12 19.5425" stroke="#020C01" stroke-width="1.5" stroke-linecap="round" stroke-linejoin="round" /> 477 </g> 478 <defs> 479 <clipPath id="clip0_30_108"> 480 <rect width="16" height="16" fill="white" transform="translate(12 0.68634) rotate(45)" /> 481 </clipPath> 482 </defs> 483</svg> 484</a> 485 486 </div> 487 </div> 488</section> 489 490<section class="text-section m-standard"> 491 <div class="content-standard"> 492 <div class="text-block-xl"> 493 494 495 496 </div> 497 <div class="text-columns"> 498 499 <div class="ew-html slide-from-bottom" data-inviewanimation> 500 <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>1. Gibson, I. R., Lopes, V. R., Oliver, R., Wang, T., Wills, D., Buckland, T., & Walsh, W. R. (2025b). Early new bone formation in ovine intramuscular defects: comparison between different silicate-containing calcium phosphate synthetic bone grafts. Journ
500al of Orthopaedic Surgery and Research, 20(1), 369. https://doi.org/10.1186/s13018-025-05740-0</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>2. Conway, J. C., Oliver, R. A., Wang, T., Wills, D. J., Herbert, J., Buckland, T., Walsh, W. R., & Gibson, I. R. (2021c). The efficacy of a nanosynthetic bone graft substitute as a bone graft extender in rabbit posterolateral fusion. The Spine Journal, 21(11), 1925â1937. https://doi.org/10.1016/j.spinee.2021.05.017</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>â Results from pre-clinical testing may not be predictive of clinical experience in humans</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>* Data on file</em></p></div> 501 </div> 502 503 </div> 504 505 </div> 506</section> 507 508 </div> 509 <footer> 510 <div class="content-wide bgcolor-main-dark"> 511 <div class="footer-main"> 512 513 <div class="footer-col col-xlphone-24 "> 514 <h4>Products</h4> 515 516 <a href="/bone-graft-substitute">OssDsign Catalyst®</a> 517 518 </div> 519 520 <div class="footer-col col-xlphone-24 m-xlphone-t-3"> 521 <h4>Company</h4> 522 523 <a href="/about-ossdsign">About us</a> 524 525 <a href="/board">Board of Directors</a> 526 527 <a href="/team">Management Team</a> 528 529 </div> 530 531 <div class="footer-col col-xlphone-24 m-xlphone-t-3"> 532 <h4>Investors</h4> 533 534 <a href="/share-english">Share</a> 535 536 <a href="/analysts">Analysts</a> 537 538 <a href="/reports-engelska">Financial Reports</a> 539 540 <a href="/presentations">Presentations</a> 541 542 <a href="/corporate-governance-engelska">Corporate Governance</a> 543 544 <a href="/calendar-engelska">Financial Calendar</a> 545 546 <a href="/owners">Owners</a> 547 548 </div> 549 550 <div class="footer-col col-xlphone-24 m-xlphone-t-3"> 551 <h4>Legal</h4> 552 553 <a href="/global/policy">Privacy Policy</a> 554 555 <a href="/cookie-policy">Cookie Policy</a> 556 557 </div> 558 559 <div class="footer-col col-tablet-24 m-xlphone-t-3"> 560 <h4>Follow us</h4> 561 <div class="social-media"> 562 563 <a class="icon" aria-label="OssDsign AB page on linkedin" target="_blank" href="https://www.linkedin.com/company/ossdsign-ab"> 564 <svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" viewBox="0 0 448 512" fill="currentColor"> 565 <path d="M100.28 448H7.4V148.9h92.88zM53.79 108.1C24.09 108.1 0 83.5 0 53.8a53.79 53.79 0 0 1 107.58 0c0 29.7-24.1 54.3-53.79 54.3zM447.9 448h-92.68V302.4c0-34.7-.7-79.2-48.29-79.2-48.29 0-55.69 37.7-55.69 76.7V448h-92.78V148.9h89.08v40.8h1.3c12.4-23.5 42.69-48.3 87.88-48.3 94 0 111.28 61.9 111.28 142.3V448z" /> 566</svg> 567 </a> 568 <a class="icon" aria-label="OssDsign AB page on twitter" target="_blank" href="https://twitter.com/OssDsign">
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