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277            
278            <h1 class="label-color-word slide-from-bottom" ews-color="word" data-inviewanimation>OssDsign Catalyst&#xAE;</h1>
279            <p class="m-b-z m-xlphone-t-1 slide-from-bottom" data-inviewanimation>Real world data. Real world results.™</p>
280        </div>
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285<section class="text-section  m-standard">
286    <div class="content-standard">
287        <div class="text-block-xl">
288            <span class="title slide-from-bottom" data-inviewanimation>Bone healing is not a single event</span>
289            
290            
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292        <div class="text-columns">
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295                    <div><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Successful outcomes depend on early, rapid bone formation as well as continued maturation and remodeling to form stable, integrated bone.</h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">That understanding is reflected in the design of OssDsign Catalyst®, engineered to support healing across the full bone healing cascade from formation through remodeling.<sup>1,2</sup></h5></div>
296                </div>
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299        
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308                </figure>
309            </div>
310            <div class="col-10 col-mdtablet-24 column justify-end">
311                <div class="text-content slide-from-bottom" data-inviewanimation>
312                    <h2 class="title">OssDsign Catalyst</h2>
313                    <div><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">A nanosynthetic, silicate-substituted bone graft designed to upregulate cellular BMP-2, drive dual-pathway healing, including endochondral ossification, and cell-mediated coupled remodeling, enabling rapid, robust fusion in challenging environments.<sup>1,2*</sup></p></div>
314                    <a class="btn btn-primary m-t-3" href="/clinical-evidence" target="_blank">View the evidence<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg">
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377                    
378                            <figure class="slide-from-bottom" data-inviewanimation>
379                                <img src="https://www.ossdsign.com/upl/images/1272541/catalyst-moa-graphic-website-4_1600_0_2_thumb.webp?t=835441860" style="width: 500px; height: 400px;" alt="Catalyst MOA Graphic_website_4" />
380                                
381                            </figure>
382                    
383                </div>
384            
385        </div>
386    </div>
387</section><section class="text-media-section m-standard">
388    <div class="content-standard">
389        <div class="text-media row direction-row-reverse reversed">
390            <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z row justify-end">
391                <figure class="media-content" data-inviewanimation>
392                    <img alt="1029x685px_beige_blurbackground_textright" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268622/1029x685px-beige-blurbackground-textright_1060_550_2_thumb.webp?t=833886300" />
393                </figure>
394            </div>
395            <div class="col-10 col-mdtablet-24 column justify-end">
396                <div class="text-content slide-from-bottom" data-inviewanimation>
397                    <h2 class="title">Bone formation starts with cellular signaling</h2>
398                    <div><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></h5><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><u>Cellular BMP-2 upregulation</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Silicate ions are substituted directly into Catalyst’s core chemistry, rather than coated on the surface or delivered via a carrier, enabling sustained silicate signaling from early healing through remodeling. Its high surface area mirrors native bone at the nanoscale, extending throughout the graft.<sup>1,2†</sup> Together, these features are designed to stimulate cellular BMP-2 activity, driving rapid bone formation.<sup>*†</sup></p></div>
399                    
400                </div>
401            </div>
402        </div>
403    </div>
404</section><section class="text-media-section m-standard">
405    <div class="content-standard">
406        <div class="text-media row ">
407            <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z ">
408                <figure class="media-content" data-inviewanimation>
409                    <img alt="1029x685px_blue_blurbackground_textleft" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268623/1029x685px-blue-blurbackground-textleft_1060_550_2_thumb.webp?t=833886300" />
410                </figure>
411            </div>
412            <div class="col-10 col-mdtablet-24 column justify-end">
413                <div class="text-content slide-from-bottom" data-inviewanimation>
414                    <h2 class="title">Cellular signaling drives how bone forms</h2>
415                    <div><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><br></p><h5 style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;"><u>Dual-pathway healing</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">Similar to rhBMP-2 and autograft, Catalyst activates endochondral ossification, the body’s primary fracture repair mechanism. Most synthetics rely solely on intramembranous bone formation. This facilitates fusion even in challenging avascular environments, such as the center of the fusion mass or large defects.<sup>2†</sup> By leveraging both pathways, Catalyst is designed to support bone formation in complex clinical scenarios.<sup>1,2†</sup></p></div>
416                    
417                </div>
418            </div>
419        </div>
420    </div>
421</section><section class="text-media-section m-standard">
422    <div class="content-standard">
423        <div class="text-media row direction-row-reverse reversed">
424            <div class="col-14 col-mdtablet-24 p-b-7 p-mdtablet-z row justify-end">
425                <figure class="media-content" data-inviewanimation>
426                    <img alt="1029x685px_pink_blurbackground_textright" class="ew-media" loading="lazy" src="https://www.ossdsign.com/upl/images/1268628/1029x685px-pink-blurbackground-textright_1060_550_2_thumb.webp?t=833886360" />
427                </figure>
428            </div>
429            <div class="col-10 col-mdtablet-24 column justify-end">
430                <div class="text-content slide-from-bottom" data-inviewanimation>
431                    <h2 class="title">Bone formation starts the process – remodeling completes it</h2>
432                    <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><br></p><h5 style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><u>Cell-mediated coupled remodeling</u></h5><p style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 0in; text-align: left; direction: ltr; unicode-bidi: embed; word-break: normal;">&nbsp;In clinically relevant, challenging preclinical models, Catalyst has demonstrated coupled remodeling as early as 6 weeks. Catalyst is replaced by new bone, reflecting cell-mediated active healing. The result is functional, robust bone that integrates with native bone.<sup>1,2†</sup></p></div>
433                    
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435            </div>
436        </div>
437    </div>
438</section>
439<section class="text-section  m-standard">
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442            <span class="title slide-from-bottom" data-inviewanimation>First class handling</span>
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447            
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449                    <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Available for immediate use</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Easy intra-operative manipulation</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Mixes well 1:1 with local autograft</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Packs well into an interbody cage</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Pushes easily down a canula</p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;">– Cleared for standalone use in the extremities</p></div>
450                </div>
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467                    <div><table style="width: 100%;"><tbody><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);"><strong>Article number</strong><br></td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);"><strong>Description</strong><br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);"><strong>Size</strong><br></td></tr><tr><td style="width: 20.2285%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">104010</td><td style="width: 62.6635%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">1 cc</td></tr><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);">104025</td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);">2.5 cc</td></tr><tr><td style="width: 20.2285%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">104050</td><td style="width: 62.6635%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; background-color: rgb(230, 230, 250); border-color: rgb(0, 0, 0);">5 cc</td></tr><tr><td style="width: 20.2285%; border-color: rgb(0, 0, 0);">104100</td><td style="width: 62.6635%; border-color: rgb(0, 0, 0);">OssDsign Catalyst Nanosynthetic Bone Graft Putty<br></td><td style="width: 17.0408%; border-color: rgb(0, 0, 0);">10 cc</td></tr></tbody></table><p><br></p></div>
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473                <a class="btn btn-primary" href="https://www.ossdsign.com/upl/files/257062/2021-2225-ossdsign-catalyst-ifu-rev04-original-layout.pdf?t=827244180" target="_blank">Download the OssDsign Catalyst IFU<svg width="24" height="24" viewBox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg">
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500                    <div><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>1. Gibson, I. R., Lopes, V. R., Oliver, R., Wang, T., Wills, D., Buckland, T., &amp; Walsh, W. R. (2025b). Early new bone formation in ovine intramuscular defects: comparison between different silicate-containing calcium phosphate synthetic bone grafts. Journ
500al of Orthopaedic Surgery and Research, 20(1), 369. https://doi.org/10.1186/s13018-025-05740-0</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>2. Conway, J. C., Oliver, R. A., Wang, T., Wills, D. J., Herbert, J., Buckland, T., Walsh, W. R., &amp; Gibson, I. R. (2021c). The efficacy of a nanosynthetic bone graft substitute as a bone graft extender in rabbit posterolateral fusion. The Spine Journal, 21(11), 1925–1937. https://doi.org/10.1016/j.spinee.2021.05.017</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>† Results from pre-clinical testing may not be predictive of clinical experience in humans</em></p><p style="language:en-SE;margin-top:0pt;margin-bottom:0pt;margin-left:0in; text-align:left;direction:ltr;unicode-bidi:embed;mso-line-break-override:none; word-break:normal;punctuation-wrap:hanging;"><em>* Data on file</em></p></div>
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