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436                  id="page-header-video"
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438                  title="Rani simptomi spinalne mišićne atrofije (SMA) tip 1"
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440                  loop autoplay playsinline muted preload="auto">
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449                        <h1 class="heading-width-3">KAKO UOČITI RANE SIMPTOME SPINALNE MIŠIĆNE ATROFIJE (SMA)<sup>1–3</sup></h1>
450                    </div>
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454
455      
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458<div id="block-hcpwhatissma" class="block block-block-content block-block-content38bc904b-8b20-415a-8d2c-1c11439a0711">
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467                <img src="/sites/default/files/2021-10/Signs%20of%20SMA_Croatia_COLOUR.png" width="205" height="65" class="mx-auto d-block" alt="" title="" class="img-responsive ageContent age1">
468            </div>
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470
471        <div class="paragraph paragraph-medium paragraph-width-1 paragraph-blue mt-xs-20 row mx-xs-0">
472            <div class="col-xs-12 centered">
473                <p>
474            <div class="clearfix text-formatted field field--name-field-hcp-text1 field--type-text-long field--label-hidden field__item"><p>Za djecu koja boluju od SMA, pravovremena dijagnoza je od najvećeg značaja, jer se oštećenja donjeg motoričkog neurona do kojih dolazi prije pružanja medicinske pomoći ne mogu izliječiti<sup>4,5</sup></p>
475</div>
476      </p>
477            </div>
478        </div>
479
480
481
482        <div class="paragraph paragraph-medium paragraph-width-1 paragraph-blue mt-xs-30 row mx-xs-0">
483            <div class="col-xs-12 centered">
484                <div class="top-hr bg-sma-turquoise-25"></div>
485                <h2 class="mb-xs-30">
486            <div class="clearfix text-formatted field field--name-field-hcp-heading1 field--type-text field--label-hidden field__item">Å TO JE SMA?</div>
487      </h2>
488                <p>
489            <div class="clearfix text-formatted field field--name-field-hcp-text2 field--type-text-with-summary field--label-hidden field__item"><p>SMA je rijetka, progresivna, nasljedna monogenska bolest, koju karakterizira nepravilnost donjeg motoričkog neurona i mišićna slabost<sup>6–10</sup></p>
490</div>
491      </p>
492            </div>
493        </div>
494
495        <div class="paragraph paragraph-small paragraph-width-2 paragraph-black mt-xs-10 row mx-xs-0">
496            <div class="col-xs-12 mx-md-auto centered">
497                <p class="mb-10">
498            <div class="clearfix text-formatted field field--name-field-hcp-text3 field--type-text-long field--label-hidden field__item"><p>Ako se ne liječi, SMA je drugi najčešći smrtonosni autosomno recesivni poremećaj nakon cistične fibroze.<sup>11</sup></p>
499</div>
500      </p>
501                <p>
502            <div class="clearfix text-formatted field field--name-field-hcp-text4 field--type-text-long field--label-hidden field__item"><p>SMA je vodeći genetski uzrok smrtnosti novorođenčadi bez terapijske intervencije<sup>5,10</sup></p>
503</div>
504      </p>
505            </div>
506        </div>
507
508        <div class="fact-boxes w2 mt-xs-30 justify-content-center row mx-xs-0">
509            <div class="col-xs-12 mx-md-auto">
510                <div class="row d-flex justify-content-md-center">
511                    <div class="fact-box centered d-flex justify-content-md-center align-items-center col-md-3 col-xs-12 pl-xs-0 pl-md-4 text-sma-turquoise">
512                        <div data-animation-name="hcp-1in10k" data-loop="On" class="svg centered" title="Što je spinalna mišićna atrofija (SMA)"></div>
513                        <p>
514            <div class="clearfix text-formatted field field--name-field-hcp-text5 field--type-text-long field--label-hidden field__item"><p>SMA pogađa približno 1 od <span style="white-space: nowrap;">10 000 – 12 000</span> novorođenčadi i pojavnost je jednaka kod svih rasa i spolova<sup>6,12</sup></p>
515</div>
516      </p>
517                    </div>
518                    <div class="fact-box centered d-flex justify-content-md-center align-items-center col-md-3 col-xs-12 pl-xs-0 pl-md-4 text-sma-turquoise">
519                        <div data-animation-name="hcp-1in58" data-loop="On" class="svg centered" title="Što je spinalna mišićna atrofija (SMA)"></div>
520                        <p>
521            <div class="clearfix text-formatted field field--name-field-hcp-text6 field--type-text-long field--label-hidden field__item"><p>Više od 1 na 58 osoba su nositelji mutacije te bolesti<sup>13</sup></p>
522</div>
523      </p>
524                    </div>
525                </div>
526            </div>
527        </div>
528
529        <div class="paragraph paragraph-small paragraph-width-2 paragraph-black my-xs-20 row mx-xs-0">
530            <div class="col-12 mx-md-auto px-xs-4 centered">
531                <p>
532            <div class="clearfix text-formatted field field--name-field-hcp-text7 field--type-text-long field--label-hidden field__item"><p>SMA se obično klasificira prema 4 fenotipa (tip 1–4) teških bolesti. SMA tip 1 i 2 najteži su i najčešći oblici koji se pojavljuju između rođenja i 18 mjeseci<sup>3,5,10</sup></p>
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566
567                      <section class="region region-hcp-sma-cause-top">
568    <div id="block-causeofsma" class="block block-block-content block-block-content0cbf8c73-636e-4187-8f23-efd373a78351">
569  
570    
571      <div class="content">
572
573        <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue pt-xs-30 row mx-xs-0">
574            <div class="col-xs-12 mx-md-auto centered">
575                <div class="top-hr bg-sma-turquoise-50"></div>
576                <h2 class="mb-xs-30">
577            <div class="clearfix text-formatted field field--name-field-cause-heading1 field--type-text field--label-hidden field__item">UZROK SMA</div>
578      </h2>
579                <p>
580            <div class="clearfix text-formatted field field--name-field-cause-text1 field--type-text-long field--label-hidden field__item"><p>SMA je uzrokovana odsutnošću ili nefunkcionalnim genom za preživljavanje motoričkog neurona 1 (<em>PMN1</em>)<sup>14–18</sup></p>
581</div>
582      </p>
583            </div>
584        </div>
585
586        <div class="paragraph paragraph-small paragraph-width-2 paragraph-black py-xs-20 row mx-xs-0">
587            <div class="col-xs-12 mx-md-auto centered">
588                <p>
589            <div class="clearfix text-formatted field field--name-field-cause-text2 field--type-text-long field--label-hidden field__item"><p>Tijelo ima rezervni gen <em>SMN2</em>, koji, međutim, može proizvesti samo malu količinu funkcionalnog SMN proteina, nedovoljnu za preživljavanje i rad motoričkih neurona<sup>6,14,15,17,18</sup></p>
590</div>
591      </p>
592            </div>
593        </div>
594
595
596    </div>
597  </div>
598
599  </section>
600
601
602
603
604                <div id="differenceTabs" class="tabgroup row mx-xs-0">
605
606
607                          <section class="region region-hcp-sma-cause-tab-header">
608    <div id="block-effecteddifference" class="block block-block-content block-block-content8fb22ea4-d94f-4506-8521-e1954a56520e">
609  
610    
611      <div class="content">
612      
613        <div class="tabgroup-heading mt-30 col-xs-12">
614            
615            <div class="clearfix text-formatted field field--name-field-effect-text1 field--type-text-long field--label-hidden field__item"><p class="tabgroup-label mb-xs-10 text-sma-turquoise">Kliknite kako biste vidjeli razliku</p>
616</div>
617      
618            <ul class="nav nav-tabs tab-turquoise" role="tablist">
619                <li role="presentation" class="tab-item tab1 active">
620                    <a data-tab="#diffTab1" aria-controls="tab1" role="tab" data-toggle="tab">
621            <div class="clearfix text-formatted field field--name-field-effect-link1 field--type-text field--label-hidden field__item">ZDRAVA OSOBA</div>
622      </a>
623                </li>
624                <li role="presentation" class="tab-item tab2">
625                    <a data-tab="#diffTab2" aria-controls="tab2" role="tab" data-toggle="tab">
626            <div class="clearfix text-formatted field field--name-field-effect-link2 field--type-text field--label-hidden field__item">OBOLJELA OSOBA</div>
627      </a>
628                </li>
629            </ul>
630        </div>
631      
632    </div>
633  </div>
634
635  </section>
636
637
638
639                    <div class="tabgroup-content mt-xs-10 col-xs-12 p-xs-4 bg-white">
640
641
642                              <section class="region region-hcp-sma-cause-tabs">
643    <div id="block-unaffectedindividuals" class="block block-block-content block-block-content61c8b258-139c-4685-b4da-e3c542870004">
644  
645    
646      <div class="content">
647      
648        <div id="diffTab1" class="row tab-padded tab-pane show active" role="tabpanel"
649			aria-labelledby="nav-difference-unaffected-tab">
650            <div class="col-ds-5 col-xs-12 pt-md-20 pl-md-50">
651                <h3 class="underline">Zdrava osoba</h3>
652				<div class="small-container styled-list-conainer">
653					<ul class="styled-list">
654	<li>
655	<p class="small">SMN protein je presudan za preživljavanje neurona i stvaranje neuromuskularnih spojeva<sup>15</sup></p>
656	</li>
657	<li>
658	<p class="small"><em>SMN1</em> je primarni gen koji kodira SMN protein, a <em>SMN2</em> je rezervni gen<sup>15,19</sup></p>
659	</li>
660</ul>
661
662				</div>
663                <div class="diff-key d-xs-none d-ds-block ml-ds-50">
664                    <div class="key-item">
665                        <div class="circle bg-sma-fuchsia"></div>
666                        <div class="circle bg-sma-turquoise"></div>
667                        <p class="small">Funkcionalni SMN protein</p>
668
669                    </div>
670                    <div class="key-item">
671                        <div class="circle bg-sma-fuchsia-25 q3"></div>
672                        <div class="circle bg-sma-turquoise-25 q3"></div>
673                        <p class="small">Nefunkcionalni SMN protein</p>
674
675                    </div>
676                </div>
677            </div>
678            <div class="col-lg-6 col-ds-7 mx-xs-0 mx-lg-auto pb-ds-30 col-xs-12">
679                <video poster="/sites/default/files/2021-10/Unaffected-Individual_0.jpg" alt="Uzrok spinalne mišićne atrofije (SMA) kod zdrave osobe" title="Uzrok spinalne mišićne atrofije (SMA) kod zdrave osobe" playsinline webkit-playsinline muted loop class="mb-30 video-js">
680                    <source src="/sites/default/files/2021-10/Unaffected%20Individual_Croatia_v1.mp4" type="video/mp4">
681                </video>
682            </div>
683        </div>
684      
685    </div>
686  </div>
687<div id="block-affectedindividuals" class="block block-block-content block-block-contentd61657ad-6075-4621-b1d0-d159f3a99922">
688  
689    
690      <div class="content">
691      
692        <div id="diffTab2" class="row tab-padded tab-pane p-xs-0" role="tabpanel"
693            aria-labelledby="nav-difference-affected-tab">
694            <div class="col-ds-5 col-xs-12 pt-md-20 pl-md-50">
695                <h3 class="underline">OBOLJELJA OSOBA</h3>
696                <div class="small-container styled-list-conainer">
697                    <ul class="styled-list">
698	<li>
699	<p class="small">Nema <em>PMN1 </em> gena ili je nefunkcionalan<sup>14–17</sup></p>
700	</li>
701	<li>
702	<p class="small">Gen <em>PMN2</em> sam ne može proizvesti dovoljno PMN proteina<sup>6,14,15,18</sup></p>
703	</li>
704	<li>
705	<p class="small">Nedostatak PMN proteina dovodi do nepovratnog oštećenja neurona i gubitka funkcije mišića kod oboljelih od SMA<sup>5,14,15</sup></p>
706	</li>
707</ul>
708
709                </div>
710                <div class="diff-key ml-ds-50 d-xs-none d-ds-block ml-ds-50">
711                    <div class="key-item">
712                        <div class="circle bg-sma-turquoise"></div>
713                        <p class="small">Funkcionalni PMN protein</p>
714
715                    </div>
716                    <div class="key-item">
717                        <div class="circle bg-sma-turquoise-25 q3"></div>
718                        <p class="small">Nefunkcionalni PMN protein</p>
719
720                    </div>
721                </div>
722            </div>
723            <div class="col-lg-6 col-ds-7 mx-xs-0 mx-lg-auto pb-ds-30 col-xs-12">
724                <video poster="/sites/default/files/2021-10/Affected-Individual_0.jpg" alt="Uzrok spinalne mišićne atrofije (SMA) u oboljelih osoba" title="Uzrok spinalne mišićne atrofije (SMA) u oboljelih osoba" playsinline webkit-playsinline muted loop class="mb-30 video-js">
725                    <source src="/sites/default/files/2021-10/Affected%20Individual_Croatia_v1.mp4" type="video/mp4">
726                </video>
727            </div>
728        </div>
729      
730    </div>
731  </div>
732
733  </section>
734
735
736
737                    </div>
738                </div>
739            </div>
740        </div>
741
742        <div class="container-fluid px-xs-0 overflow-hide">
743            <div class="container">
744
745
746                      <section class="region region-hcp-neuronal-top">
747    <div id="block-neuronalloss" class="block block-block-content block-block-content63459cc3-9ebb-426f-9365-382959c2ae64">
748  
749    
750      <div class="content">
751      
752        <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue mt-xs-30 mx-xs-0 row mx-xs-0">
753            <div class="col-xs-12 px-xs-0 centered">
754                <div class="top-hr bg-sma-turquoise-50"></div>
755                <h2 class="mb-30">
756            <div class="clearfix text-formatted field field--name-field-neuronal-heading field--type-text field--label-hidden field__item">PREVENCIJA TRAJNIH OŠTEĆENJA NEURONA</div>
757      </h2>
758                <p>
759            <div class="clearfix text-formatted field field--name-field-neuronal-text field--type-text-long field--label-hidden field__item"><p>Oštećenje motoričkih neurona je kod SMA neizlječivo<sup>4,5</sup></p>
760</div>
761      </p>
762            </div>
763        </div>
764      
765    </div>
766  </div>
767
768  </section>
769
770
771
772                <div id="ageTabs1" class="tabgroup row mx-xs-0 ageTabs">
773
774
775                          <section class="region region-hcp-neuronal-tabs-header">
776    <div id="block-ageselection" class="block block-block-content block-block-content4767c54f-f3e4-45f6-901e-6ba9615bc005">
777  
778    
779      <div class="content">
780      
781        <div class="tabgroup-heading mt-30 col-xs-12 px-xs-0">
782            <p class="tabgroup-label mb-xs-10 text-sma-fuchsia">Odaberite dob:</p>
783
784            <ul class="nav nav-tabs" role="tablist">
785                <li role="presentation" class="tab-item tab1 age1 active">
786                    <a data-tab=".age1" aria-controls="tab1" role="tab" data-toggle="tab">0–6 MJESECI</a>
787                </li>
788                <li role="presentation" class="tab-item tab2 age2">
789                    <a data-tab=".age2" aria-controls="tab2" role="tab" data-toggle="tab">6–18 MJESECI</a>
790                </li>
791            </ul>
792        </div>
793      
794    </div>
795  </div>
796
797  </section>
798
799
800
801                    <div class="tabgroup-content mb-30 col-xs-12 px-xs-0 bg-white">
802
803
804                              <section class="region region-hcp-neuronal-tabs">
805    <div id="block-hcpagerange1" class="block block-block-content block-block-content3fea1eb4-b37e-4e06-b12a-f9b607165eb6">
806  
807    
808      <div class="content">
809
810        <div id="ageTab1" class="age1 row mx-xs-0 tab-padded tab-pane show active" role="tabpanel">
811            <div class="col-xs-12 col-md-6 mb-xs-30 px-xs-0 centered">
812                <h3 class="underline mx-auto">Uznapredovalost bolesti</h3>
813                <p class="small mb-xs-10">Više od 90% bolesnika kojima nije pružena medicinska pomoć, a boluju od SMA tipa 1, ne preživi ili zahtijeva stalnu respiratornu njegu do 2. godine života<sup>20</sup></p>
814
815<p class="small mb-xs-10">Odgađanje dijagnoze SMA tipa 1 može uzrokovati trajno oštećenje donjeg motoričkog neurona<sup>4</sup> te tako izravno utjecati na živčano-mišićne funkcije pacijenta<sup>21</sup></p>
816
817<p class="small"><strong>Vaša brza reakcija i upućivanje na pružanje medicinske pomoći presudni 
817su za zaustavljanje ili odgodu uznapredovalosti bolesti te omogućuje pacijentu najbolju dostupnu njegu<sup>4,10,22</sup></strong></p>
818
819            </div>
820            <div class=" col-xs-12 mb-xs-30 px-xs-0">
821
822                                  <div data-animation-name="hcp-01-d-01"
823                       data-loop="Off"
824                       class="chart-img d-xs-none d-md-block my-xs-2 svg centered scroll-on-show is-visible"
825                       title="Napredovanje spinalne mišićne atrofije (SMA) tip 1 u dojenčadi 0-6 mjeseci">
826                      <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_1-CR_0.json">
827                  </div>
828                
829                                  <div data-animation-name="hcp-01-m-01"
830                       data-loop="Off"
831                       class="chart-img d-xs-block d-md-none my-xs-2 svg centered scroll-on-show is-visible"
832                       title="Napredovanje spinalne mišićne atrofije (SMA) tip 1 u dojenčadi 0-6 mjeseci">
833                      <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_MOBILE_Graph_1-CR_0.json">
834                  </div>
835                
836                
837                <div class="row mx-xs-0">
838                    <div class="col-md-4 col-xs-12 px-xs-0 mb-md-0 mb-xs-4">
839                        <div class="snr-key">
840                            <div>
841                                <div class="circle bg-sma-blue"></div>
842                                <p class="smaller">Neuromuskularna klinička istraživanja kod djece: Postotak preživljavanja oboljelih od SMA tipa 1*</p>
843
844                            </div>
845                            <div>
846                                <div class="circle bg-sma-fuchsia"></div>
847                                <p class="smaller">NeuroNext: Postotak preživljavanja oboljelih od SMA tipa 1*</p>
848
849                            </div>
850                        </div>
851                    </div>
852                    <div class="notes col-md-8 col-xs-12 px-xs-0 mb-xs-4">
853                        <p class="footnote pl-xs-0 pl-md-4">*Postotak preživljavanja bez težih posljedica prema neuromuskularnim kliničkim istraživanjima djece = nema smrtnosti i nema potrebe za ≥16 sati / dan neprekidnom respiratornom njegom u trajanju od 14 dana, ako se nije razvila akutna reverzibilna bolest;<sup>20</sup> n=23 (Pacijenti tipa 1 s 2 gena <em>SMN2</em>). Postotak preživljavanja prema NeuroNext = nema smrtnosti ni intubacije; n = 20<sup>21</sup></p>
854
855<p class="footnote pl-xs-0 pl-md-4">Izvori: Anderton RS i Mastaglia FL. 2015<sup>15</sup>, Finkel RS. 2013<sup>24</sup>, Finkel RS <em>i sur</em>. 2014<sup>20</sup> i Kolb SJ <em>i sur</em>. 2017<sup>21</sup></p>
856
857                    </div>
858                </div>
859            </div>
860        </div>
861
862    </div>
863  </div>
864<div id="block-hcpagerange2" class="block block-block-content block-block-content7e38a2a1-ed49-4660-a22f-73ef2cb6d856">
865  
866    
867      <div class="content">
868
869        <div id="ageTab2" class="age2 row mx-xs-0 tab-padded tab-pane" role="tabpanel">
870            <div class="col-lg-5 col-xs-12 pb-xs-20 px-xs-0 pr-md-4">
871                <h3 class="underline">Uznapredovalost bolesti</h3>
872                <p class="small mb-xs-10">Iako pacijenti kojima je dijagnosticiran SMA tip 2 (između 6–18 mjeseci života) u nekim slučajevima razviju motoričke sposobnosti u prvim godinama života, tijekom dugoročnijeg praćenja pokazuju jasan i progresivan pad<sup>8</sup></p>
873
874<p class="small mb-xs-10">Odgađanjem dijagnoze SMA dolazi do trajnog oštećenja nižih motoričkih neurona,<sup>4</sup> što izravno utječe na neuromuskularnu funkciju<sup>4,10,22</sup></p>
875
876<p class="small mb-xs-10"><strong>Pravovremeno upućivanje na liječenje presudno je za zaustavljanje ili odgađanje uznapredovalosti bolesti i omogućuje pacijentu pristup najboljoj dostupnoj njezi<sup>4,10,22</sup></strong></p>
877
878            </div>
879            <div class="col-lg-7 col-xs-12 pb-xs-30 px-xs-0 pt-lg-60 pl-md-4">
880
881                                    <div data-animation-name="hcp-02-d-01"
882                         data-loop="Off"
883                         class="chart-img d-xs-none d-md-block my-xs-2 svg centered scroll-on-show is-visible"
884                         title="Spinalna mišićna atrofija (SMA) tip 2 napredovanje bolesti u dojenčadi 6-18 mjeseci">
885                        <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_3-CR.json">
886                    </div>
887                
888                                    <div data-animation-name="hcp-02-m-01"
889                         data-loop="Off"
890                         class="chart-img d-xs-block d-md-none my-xs-2 svg centered scroll-on-show is-visible"
891                         title="Spinalna mišićna atrofija (SMA) tip 2 napredovanje bolesti u dojenčadi 6-18 mjeseci">
892                        <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_MOBILE_Graph_3-CR.json">
893                    </div>
894                
895                
896                <div class="ml-xs-0 pl-md-9pc pl-xs-5pc">
897                    <p class="footnote mt-xs-10">
897TIMPSI: Test motoričkih sposobnosti novorođenčadi</p>
898
899<p class="footnote mt-xs-2">Preuzeto iz Kolb SJ, <em>i sur</em>. 2017.<sup>21</sup></p>
900
901                </div>
902            </div>
903        </div>
904
905    </div>
906  </div>
907
908  </section>
909
910
911
912                    </div>
913                </div>
914            </div>
915        </div>
916
917
918        <div class="container-fluid px-xs-0 bg-sma-turquoise-10 overflow-hide-x">
919            <div class="container px-xs-0">
920
921
922                      <section class="region region-hcp-early-diag">
923    <div id="block-importance" class="block block-block-content block-block-content33acb831-424f-40b6-af06-41fce39c7c6d">
924  
925    
926      <div class="content">
927     
928     <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue py-xs-30 pb-xs-0 pb-md-30 row">
929        <div class="col-xs-12 centered">
930            <div class="top-hr bg-sma-turquoise-50"></div>
931            <h2 class="mb-md-30">
932            <div class="clearfix text-formatted field field--name-field-importance-heading field--type-text field--label-hidden field__item">ZNAČAJ RANE DIJAGNOZE</div>
933      </h2>
934            <p>
935            <div class="clearfix text-formatted field field--name-field-importance-text field--type-text-long field--label-hidden field__item"><p>Pravovremena dijagnoza SMA je od najvećeg značaja, jer su oštećenja neurona do kojih dolazi prije pružanja medicinske pomoći neizliječiva<sup>4,5</sup></p>
936</div>
937      </p>
938        </div>
939    </div>
940     
941    </div>
942  </div>
943<div id="block-hcpearliersignsofsma" class="block block-block-content block-block-content39248b85-1797-46dd-9128-55ac49ddee19">
944  
945    
946      <div class="content">
947
948        <div class="row mx-xs-0">
949            <div class="col-xs-12 p-md-4 pt-xs-20 pb-xs-0 mx-md-auto mb-xs-0 mb-md-30 bg-white">
950                <div class="row mx-auto mb-xs-0">
951                    <div class="col-lg-5 col-ds-6 col-xs-12 pt-md-20 pl-ds-50 pr-xs-0 pr-lg-4 small-container styled-list-container">
952                        <h3 class="underline">Pravovremena dijagnoza SMA presudna je za:<sup>25–27</sup></h3>
953                        <ul class="styled-list">
954	<li>
955	<p class="small">Određivanje optimalne terapije i strategije borbe s bolešću</p>
956	</li>
957	<li>
958	<p class="small">Oslobađanje pacijenta i njegovatelja od stresa i tereta</p>
959	</li>
960</ul>
961
962                        <p class="note small mt-xs-30 mb-xs-20"><strong>Istraživanja sugeriraju da je pravovremena medicinska pomoć od najveće koristi za pacijente oboljele od SMA<sup>10,22,28</sup></strong></p>
963
964                    </div>
965                    <div class="col-lg-7 col-ds-6 col-xs-12 pt-md-20 pr-ds-50">
966                                                    <div data-animation-name="hcp-03-d-01"
967                                 data-loop="Off"
968                                 class="chart-img d-xs-block my-xs-2 svg centered scroll-on-show is-visible"
969                                 title="Vremenski okvir dijagnoze spinalne mišićne atrofije (SMA) tipa 1 u dojenčadi 0-6 mjeseci">
970                                <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_2-CR.json">
971                            </div>
972                                                
973                        <p class="smallest mt-xs-10">Izvor: Serra-Juhe C i Tizzano EF, 2019<sup>19</sup></p>
974
975                    </div>
976                </div>
977                <div class="row clip mb-xs-0 pb-md-40 py-xs-0 py-md-30">
978                    <div class="cta-row col-xs-12 mx-xl-auto pb-xs-20 mx-xs-0 px-xs-0">
979                        <div class="call-to-action" title="Rano djelovanje moglo bi ograničiti nepovratna oštećenja povezana sa SMA (4,5,10,29)">
980                            <span>PRAVOVREMENIM DJELOVANJEM SPRIJEČIT ĆETE POJAVU NEIZLJEČIVIH OŠTEĆENJA KOJE UZROKUJE SMA<sup>4,5,10,29</sup></span>
981                            <div class="clock scroll-on-show"></div>
982                        </div>
983                    </div>
984                </div>
985            </div>
986        </div>
987
988    </div>
989  </div>
990
991  </section>
992
993
994
995            </div>
996        </div>
997
998
999          <section class="region region-hcp-about-footer">
1000    <div id="block-hcpaboutreferencesfooter" class="block block-block-content block-block-contentd9e8405c-7b4c-4c6d-b917-6ada19e2b704">
1001  
1002    
1003      <div class="content">
1004      
1005      <div class="container-fluid px-0 references-container">
1006        <div class="container">
1007            <div class="references row mx-xs-0">
1008                <div class="references-header col-xs-12 px-xs-0">
1009                    <div class="references-header-title">
1010                        <div class="references-toggle"></div>
1011                        <p>Literatura</p>
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1025            <div class="clearfix text-formatted field field--name-field-reference-header field--type-text field--label-hidden field__item">Literatura</div>
1026      </h6>
1027                            
1028            <div class="clearfix text-formatted field field--name-field-reference-descri field--type-text-long field--label-hidden field__item"><ul>
1029	<li><strong>1.</strong> Kolb SJ i Kissel JT. <em>Klin. neurol.</em> 2015;33(4):831–46. </li>
1030	<li><strong>2.</strong> Prior TW, Leach ME, Finanger E. Spinalna mišićna atrofija. 24. veljače 2000.g. [Ažurirano 14. studenoga 2019.g.]. Nalazi se u: Adam MP, Ardinger HH, Pagon RA, <em>i sur</em>. urednici. GeneReviews<sup>®</sup> [Internet]. Seattle (WA): Sveučilište u Washingtonu, Seattle; 1993-2018.</li>
1031	<li><strong>3.</strong> Wang CH, <em>i sur</em>. <em>J Dječja neurol</em>. 2007;22(8):1027–49. </li>
1032	<li><strong>4.</strong> Govoni A <em>i sur</em>. <em>Mol Neurobiol</em>. 2018;55(8):6307–18. </li>
1033	<li><strong>5.</strong> Glascock J, <em>i sur</em>. <em>J Neuromuskularne bolesti</em> 2018;5(2):145–58. </li>
1034	<li><strong>6.</strong> Verhaart IEC <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2017;12:124. </li>
1035	<li><strong>7.</strong> Richter T, <em>i sur</em>. <em>Vrijednost zdravlja</em>. 2015;18(6):906–14. </li>
1036	<li><strong>8.</strong> Mercuri E <em>i sur</em>. <em>neurologija</em> 2019; 93 (13): e1241–7. </li>
1037	<li><strong>9.</strong> Mercuri E <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2020;15(1):84. </li>
1038	<li><strong>10.</strong> Schorling DC, <em>i sur</em>. <em>J Neuromuskularne bolesti</em> 2020;7:1–13.</li>
1039	<li><strong>11.</strong> D'Amico A <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2011;6:71. </li>
1040	<li><strong>12.</strong> Pobijedite SMA (2019). O SMA. Dostupno na: https://www.curesma.org/about-sma/. Pristupljeno: 19. listopad 2020.</li>
1041	<li><strong>13.</strong> Verhaart IEC <em>i sur</em>. <em>Dodatna datoteka</em> 2: Tablica S1. Pregled učestalosti pojavnosti SMA. Dodatak Verhaart IEC, i sur. Orphanet J Rijetke bolesti 2017;12:124. Dostupno na: https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0671-8. Pristupljeno: 19. listopad 2020.</li>
1042	<li><strong>14.</strong> Coovert DD, <em>i sur</em>. <em>Hum Mol Genet</em>. 1997;6(8):1205–14. </li>
1043	<li><strong>15.</strong> Anderton RS i Mastaglia FL. <em>Stručna rev neuroter</em>. 2015;
104315:895–908. </li>
1044	<li><strong>16.</strong> Lefebvre S <em>i sur</em>. Cell. 1995;80:155–65. </li>
1045	<li><strong>17.</strong> Državni institut za zdravlje (NIH) (2020a). Literatura o genetici. Vodič kroz genetiku. <em>PMN1</em> gen. Dostupno na: https://ghr.nlm.nih.gov/gene/SMN1. Pristupljeno: 19. listopada 2020. </li>
1046	<li><strong>18.</strong> NIH (2020b). Literatura o genetici Vodič kroz genetiku. <em>PMN2</em> gen. Dostupno na: https://ghr.nlm.nih.gov/gene/SMN2. Pristupljeno: 19. listopada 2020.</li>
1047	<li><strong>19.</strong> Serra-Juhe C i Tizzano EF. <em>Eur J Human Genet</em>. 2019;27(12):1774–82. </li>
1048	<li><strong>20.</strong> Finkel RS <em>i sur</em>. <em>Neurologija</em> 2014;83(9):810–7. </li>
1049	<li><strong>21.</strong> Kolb SJ, <em>i sur</em>. <em>Ann Neurol</em>. 2017;82(6):883–91.</li>
1050	<li><strong>22.</strong> Kirschner J, <em>i sur</em>. <em>Eur J Dječja neurol</em>. 9. srpnja 2020.g.: S1090–3798 (20) 30142–2. Objavljeno na mreži prije ispisa.</li>
1051	<li><strong>23.</strong> Swoboda KJ, <em>i sur</em>. <em>Ann Neurol</em>. 2005;57(5):704–12. </li>
1052	<li><strong>24.</strong> Finkel RS. <em>Neuromuskularni poremećaji</em> 2013;23(2):112–5. </li>
1053	<li><strong>25.</strong> Qian Y, <em>i sur</em>. <em>BMC neurologija</em>. 2015;15:217. </li>
1054	<li><strong>26.</strong> Mammas IN and Spandidos DA. <em>Stručna ter. med</em>. 2018;15:3673–9.</li>
1055	<li><strong>27.</strong> Lurio JG <em>i sur</em>. <em>Am Fam Liječnik</em>. 2015;91(1):38–44. </li>
1056	<li><strong>28.</strong> Waldrop MA i Elsheikh BH. <em>Klin. neurol</em>.  2020;38(3):505–18. </li>
1057	<li><strong>29.</strong> Lowes LP, <em>i sur</em>. <em>Dječja neurol</em>. 2019;98:39–45.</li>
1058</ul>
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