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437 data-age="0" 438 title="Rani simptomi spinalne miÅ¡iÄne atrofije (SMA) tip 1" 439 data-titles="Rani simptomi spinalne miÅ¡iÄne atrofije (SMA) tip 1" 440 loop autoplay playsinline muted preload="auto"> 441 <source src="/sites/default/files/2021-10/Signs%20of%20SMA%20Website%20Header_HCP_Croatia_V1.mp4" type="video/mp4"> 442 </video> 443 <div class="video-overlay"> 444 <img src="/sites/default/files/2021-11/video-overlay-2.png" width="100%" alt="Scroll down" /> 445 </div> 446 <div class="page-header container px-0"> 447 <div class="row mt-xs-1 mt-lg-4"> 448 <div class="col-xs-12"> 449 <h1 class="heading-width-3">KAKO UOÄITI RANE SIMPTOME SPINALNE MIÅ IÄNE ATROFIJE (SMA)<sup>1â3</sup></h1> 450 </div> 451 </div> 452 </div> 453 </div> 454 455 456 </div> 457 </div> 458<div id="block-hcpwhatissma" class="block block-block-content block-block-content38bc904b-8b20-415a-8d2c-1c11439a0711"> 459 460 461 <div class="content"> 462 463 <div class="container px-0 page-container"> 464 465 <div class="row mt-xs-30 mx-xs-0"> 466 <div class="col-xs-12 centered"> 467 <img src="/sites/default/files/2021-10/Signs%20of%20SMA_Croatia_COLOUR.png" width="205" height="65" class="mx-auto d-block" alt="" title="" class="img-responsive ageContent age1"> 468 </div> 469 </div> 470 471 <div class="paragraph paragraph-medium paragraph-width-1 paragraph-blue mt-xs-20 row mx-xs-0"> 472 <div class="col-xs-12 centered"> 473 <p> 474 <div class="clearfix text-formatted field field--name-field-hcp-text1 field--type-text-long field--label-hidden field__item"><p>Za djecu koja boluju od SMA, pravovremena dijagnoza je od najveÄeg znaÄaja, jer se oÅ¡teÄenja donjeg motoriÄkog neurona do kojih dolazi prije pružanja medicinske pomoÄi ne mogu izlijeÄiti<sup>4,5</sup></p> 475</div> 476 </p> 477 </div> 478 </div> 479 480 481 482 <div class="paragraph paragraph-medium paragraph-width-1 paragraph-blue mt-xs-30 row mx-xs-0"> 483 <div class="col-xs-12 centered"> 484 <div class="top-hr bg-sma-turquoise-25"></div> 485 <h2 class="mb-xs-30"> 486 <div class="clearfix text-formatted field field--name-field-hcp-heading1 field--type-text field--label-hidden field__item">Å TO JE SMA?</div> 487 </h2> 488 <p> 489 <div class="clearfix text-formatted field field--name-field-hcp-text2 field--type-text-with-summary field--label-hidden field__item"><p>SMA je rijetka, progresivna, nasljedna monogenska bolest, koju karakterizira nepravilnost donjeg motoriÄkog neurona i miÅ¡iÄna slabost<sup>6â10</sup></p> 490</div> 491 </p> 492 </div> 493 </div> 494 495 <div class="paragraph paragraph-small paragraph-width-2 paragraph-black mt-xs-10 row mx-xs-0"> 496 <div class="col-xs-12 mx-md-auto centered"> 497 <p class="mb-10"> 498 <div class="clearfix text-formatted field field--name-field-hcp-text3 field--type-text-long field--label-hidden field__item"><p>Ako se ne lijeÄi, SMA je drugi najÄeÅ¡Äi smrtonosni autosomno recesivni poremeÄaj nakon cistiÄne fibroze.<sup>11</sup></p> 499</div> 500 </p> 501 <p> 502 <div class="clearfix text-formatted field field--name-field-hcp-text4 field--type-text-long field--label-hidden field__item"><p>SMA je vodeÄi genetski uzrok smrtnosti novoroÄenÄadi bez terapijske intervencije<sup>5,10</sup></p> 503</div> 504 </p> 505 </div> 506 </div> 507 508 <div class="fact-boxes w2 mt-xs-30 justify-content-center row mx-xs-0"> 509 <div class="col-xs-12 mx-md-auto"> 510 <div class="row d-flex justify-content-md-center"> 511 <div class="fact-box centered d-flex justify-content-md-center align-items-center col-md-3 col-xs-12 pl-xs-0 pl-md-4 text-sma-turquoise"> 512 <div data-animation-name="hcp-1in10k" data-loop="On" class="svg centered" title="Å to je spinalna miÅ¡iÄna atrofija (SMA)"></div> 513 <p> 514 <div class="clearfix text-formatted field field--name-field-hcp-text5 field--type-text-long field--label-hidden field__item"><p>SMA pogaÄa približno 1 od <span style="white-space: nowrap;">10 000 â 12 000</span> novoroÄenÄadi i pojavnost je jednaka kod svih rasa i spolova<sup>6,12</sup></p> 515</div> 516 </p> 517 </div> 518 <div class="fact-box centered d-flex justify-content-md-center align-items-center col-md-3 col-xs-12 pl-xs-0 pl-md-4 text-sma-turquoise"> 519 <div data-animation-name="hcp-1in58" data-loop="On" class="svg centered" title="Å to je spinalna miÅ¡iÄna atrofija (SMA)"></div> 520 <p> 521 <div class="clearfix text-formatted field field--name-field-hcp-text6 field--type-text-long field--label-hidden field__item"><p>ViÅ¡e od 1 na 58 osoba su nositelji mutacije te bolesti<sup>13</sup></p> 522</div> 523 </p> 524 </div> 525 </div> 526 </div> 527 </div> 528 529 <div class="paragraph paragraph-small paragraph-width-2 paragraph-black my-xs-20 row mx-xs-0"> 530 <div class="col-12 mx-md-auto px-xs-4 centered"> 531 <p> 532 <div class="clearfix text-formatted field field--name-field-hcp-text7 field--type-text-long field--label-hidden field__item"><p>SMA se obiÄno klasificira prema 4 fenotipa (tip 1â4) teÅ¡kih bolesti. SMA tip 1 i 2 najteži su i najÄeÅ¡Äi oblici koji se pojavljuju izmeÄu roÄenja i 18 mjeseci<sup>3,5,10</sup></p> 533</div> 534 </p> 535 </div> 536 </div> 537 538 </div> 539 540 <div class="container-fluid px-xs-0"> 541
542 <div class="image ageContent age1 active mt-20 img1 row mx-xs-0"> 543 <div class="col-xs-12 px-xs-0"> 544 <img src="/sites/default/files/2021-01/signs-banner-1_0.png" height="270" alt="" title="" class="img-responsive ageContent age1 active"> 545 </div> 546 </div> 547 <div class="image ageContent age2 mt-20 img1 row mx-xs-0"> 548 <div class="col-xs-12 px-xs-0"> 549 <img src="/sites/default/files/2021-01/signs-banner-2.png" height="270" alt="" title="" class="img-responsive ageContent age2"> 550 </div> 551 </div> 552 </div> 553 554 555 </div> 556 </div> 557 558 </section> 559 560 561 562 563 <div class="container-fluid px-xs-0 bg-sma-turquoise-25"> 564 <div class="container px-xs-0"> 565 566 567 <section class="region region-hcp-sma-cause-top"> 568 <div id="block-causeofsma" class="block block-block-content block-block-content0cbf8c73-636e-4187-8f23-efd373a78351"> 569 570 571 <div class="content"> 572 573 <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue pt-xs-30 row mx-xs-0"> 574 <div class="col-xs-12 mx-md-auto centered"> 575 <div class="top-hr bg-sma-turquoise-50"></div> 576 <h2 class="mb-xs-30"> 577 <div class="clearfix text-formatted field field--name-field-cause-heading1 field--type-text field--label-hidden field__item">UZROK SMA</div> 578 </h2> 579 <p> 580 <div class="clearfix text-formatted field field--name-field-cause-text1 field--type-text-long field--label-hidden field__item"><p>SMA je uzrokovana odsutnoÅ¡Äu ili nefunkcionalnim genom za preživljavanje motoriÄkog neurona 1 (<em>PMN1</em>)<sup>14â18</sup></p> 581</div> 582 </p> 583 </div> 584 </div> 585 586 <div class="paragraph paragraph-small paragraph-width-2 paragraph-black py-xs-20 row mx-xs-0"> 587 <div class="col-xs-12 mx-md-auto centered"> 588 <p> 589 <div class="clearfix text-formatted field field--name-field-cause-text2 field--type-text-long field--label-hidden field__item"><p>Tijelo ima rezervni gen <em>SMN2</em>, koji, meÄutim, može proizvesti samo malu koliÄinu funkcionalnog SMN proteina, nedovoljnu za preživljavanje i rad motoriÄkih neurona<sup>6,14,15,17,18</sup></p> 590</div> 591 </p> 592 </div> 593 </div> 594 595 596 </div> 597 </div> 598 599 </section> 600 601 602 603 604 <div id="differenceTabs" class="tabgroup row mx-xs-0"> 605 606 607 <section class="region region-hcp-sma-cause-tab-header"> 608 <div id="block-effecteddifference" class="block block-block-content block-block-content8fb22ea4-d94f-4506-8521-e1954a56520e"> 609 610 611 <div class="content"> 612 613 <div class="tabgroup-heading mt-30 col-xs-12"> 614 615 <div class="clearfix text-formatted field field--name-field-effect-text1 field--type-text-long field--label-hidden field__item"><p class="tabgroup-label mb-xs-10 text-sma-turquoise">Kliknite kako biste vidjeli razliku</p> 616</div> 617 618 <ul class="nav nav-tabs tab-turquoise" role="tablist"> 619 <li role="presentation" class="tab-item tab1 active"> 620 <a data-tab="#diffTab1" aria-controls="tab1" role="tab" data-toggle="tab"> 621 <div class="clearfix text-formatted field field--name-field-effect-link1 field--type-text field--label-hidden field__item">ZDRAVA OSOBA</div> 622 </a> 623 </li> 624 <li role="presentation" class="tab-item tab2"> 625 <a data-tab="#diffTab2" aria-controls="tab2" role="tab" data-toggle="tab"> 626 <div class="clearfix text-formatted field field--name-field-effect-link2 field--type-text field--label-hidden field__item">OBOLJELA OSOBA</div> 627 </a> 628 </li> 629 </ul> 630 </div> 631 632 </div> 633 </div> 634 635 </section> 636 637 638 639 <div class="tabgroup-content mt-xs-10 col-xs-12 p-xs-4 bg-white"> 640 641 642 <section class="region region-hcp-sma-cause-tabs"> 643 <div id="block-unaffectedindividuals" class="block block-block-content block-block-content61c8b258-139c-4685-b4da-e3c542870004"> 644 645 646 <div class="content"> 647 648 <div id="diffTab1" class="row tab-padded tab-pane show active" role="tabpanel" 649 aria-labelledby="nav-difference-unaffected-tab"> 650 <div class="col-ds-5 col-xs-12 pt-md-20 pl-md-50"> 651 <h3 class="underline">Zdrava osoba</h3> 652 <div class="small-container styled-list-conainer"> 653 <ul class="styled-list"> 654 <li> 655 <p class="small">SMN protein je presudan za preživljavanje neurona i stvaranje neuromuskularnih spojeva<sup>15</sup></p> 656 </li> 657 <li> 658 <p class="small"><em>SMN1</em> je primarni gen koji kodira SMN protein, a <em>SMN2</em> je rezervni gen<sup>15,19</sup></p> 659 </li> 660</ul> 661
662 </div> 663 <div class="diff-key d-xs-none d-ds-block ml-ds-50"> 664 <div class="key-item"> 665 <div class="circle bg-sma-fuchsia"></div> 666 <div class="circle bg-sma-turquoise"></div> 667 <p class="small">Funkcionalni SMN protein</p> 668 669 </div> 670 <div class="key-item"> 671 <div class="circle bg-sma-fuchsia-25 q3"></div> 672 <div class="circle bg-sma-turquoise-25 q3"></div> 673 <p class="small">Nefunkcionalni SMN protein</p> 674 675 </div> 676 </div> 677 </div> 678 <div class="col-lg-6 col-ds-7 mx-xs-0 mx-lg-auto pb-ds-30 col-xs-12"> 679 <video poster="/sites/default/files/2021-10/Unaffected-Individual_0.jpg" alt="Uzrok spinalne miÅ¡iÄne atrofije (SMA) kod zdrave osobe" title="Uzrok spinalne miÅ¡iÄne atrofije (SMA) kod zdrave osobe" playsinline webkit-playsinline muted loop class="mb-30 video-js"> 680 <source src="/sites/default/files/2021-10/Unaffected%20Individual_Croatia_v1.mp4" type="video/mp4"> 681 </video> 682 </div> 683 </div> 684 685 </div> 686 </div> 687<div id="block-affectedindividuals" class="block block-block-content block-block-contentd61657ad-6075-4621-b1d0-d159f3a99922"> 688 689 690 <div class="content"> 691 692 <div id="diffTab2" class="row tab-padded tab-pane p-xs-0" role="tabpanel" 693 aria-labelledby="nav-difference-affected-tab"> 694 <div class="col-ds-5 col-xs-12 pt-md-20 pl-md-50"> 695 <h3 class="underline">OBOLJELJA OSOBA</h3> 696 <div class="small-container styled-list-conainer"> 697 <ul class="styled-list"> 698 <li> 699 <p class="small">Nema <em>PMN1 </em> gena ili je nefunkcionalan<sup>14â17</sup></p> 700 </li> 701 <li> 702 <p class="small">Gen <em>PMN2</em> sam ne može proizvesti dovoljno PMN proteina<sup>6,14,15,18</sup></p> 703 </li> 704 <li> 705 <p class="small">Nedostatak PMN proteina dovodi do nepovratnog oÅ¡teÄenja neurona i gubitka funkcije miÅ¡iÄa kod oboljelih od SMA<sup>5,14,15</sup></p> 706 </li> 707</ul> 708 709 </div> 710 <div class="diff-key ml-ds-50 d-xs-none d-ds-block ml-ds-50"> 711 <div class="key-item"> 712 <div class="circle bg-sma-turquoise"></div> 713 <p class="small">Funkcionalni PMN protein</p> 714 715 </div> 716 <div class="key-item"> 717 <div class="circle bg-sma-turquoise-25 q3"></div> 718 <p class="small">Nefunkcionalni PMN protein</p> 719 720 </div> 721 </div> 722 </div> 723 <div class="col-lg-6 col-ds-7 mx-xs-0 mx-lg-auto pb-ds-30 col-xs-12"> 724 <video poster="/sites/default/files/2021-10/Affected-Individual_0.jpg" alt="Uzrok spinalne miÅ¡iÄne atrofije (SMA) u oboljelih osoba" title="Uzrok spinalne miÅ¡iÄne atrofije (SMA) u oboljelih osoba" playsinline webkit-playsinline muted loop class="mb-30 video-js"> 725 <source src="/sites/default/files/2021-10/Affected%20Individual_Croatia_v1.mp4" type="video/mp4"> 726 </video> 727 </div> 728 </div> 729 730 </div> 731 </div> 732 733 </section> 734 735 736 737 </div> 738 </div> 739 </div> 740 </div> 741 742 <div class="container-fluid px-xs-0 overflow-hide"> 743 <div class="container"> 744 745 746 <section class="region region-hcp-neuronal-top"> 747 <div id="block-neuronalloss" class="block block-block-content block-block-content63459cc3-9ebb-426f-9365-382959c2ae64"> 748 749 750 <div class="content"> 751 752 <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue mt-xs-30 mx-xs-0 row mx-xs-0"> 753 <div class="col-xs-12 px-xs-0 centered"> 754 <div class="top-hr bg-sma-turquoise-50"></div> 755 <h2 class="mb-30"> 756 <div class="clearfix text-formatted field field--name-field-neuronal-heading field--type-text field--label-hidden field__item">PREVENCIJA TRAJNIH OÅ TEÄENJA NEURONA</div> 757 </h2> 758 <p> 759 <div class="clearfix text-formatted field field--name-field-neuronal-text field--type-text-long field--label-hidden field__item"><p>OÅ¡teÄenje motoriÄkih neurona je kod SMA neizljeÄivo<sup>4,5</sup></p> 760</div> 761 </p> 762 </div> 763 </div> 764 765 </div> 766 </div> 767 768 </section> 769 770 771 772 <div id="ageTabs1" class="tabgroup row mx-xs-0 ageTabs"> 773 774 775 <section class="region region-hcp-neuronal-tabs-header"> 776 <div id="block-ageselection" class="block block-block-content block-block-content4767c54f-f3e4-45f6-901e-6ba9615bc005"> 777 778 779 <div class="content"> 780 781 <div class="tabgroup-heading mt-30 col-xs-12 px-xs-0"> 782 <p class="tabgroup-label mb-xs-10 text-sma-fuchsia">Odaberite dob:</p> 783 784 <ul class="nav nav-tabs" role="tablist"> 785 <li role="presentation" class="tab-item tab1 age1 active"> 786 <a data-tab=".age1" aria-controls="tab1" role="tab" data-toggle="tab">0â6 MJESECI</a> 787 </li> 788 <li role="presentation" class="tab-item tab2 age2"> 789 <a data-tab=".age2" aria-controls="tab2" role="tab" data-toggle="tab">6â18 MJESECI</a> 790 </li> 791 </ul> 792 </div> 793 794 </div> 795 </div> 796 797 </section> 798 799 800 801 <div class="tabgroup-content mb-30 col-xs-12 px-xs-0 bg-white"> 802 803 804 <section class="region region-hcp-neuronal-tabs"> 805 <div id="block-hcpagerange1" class="block block-block-content block-block-content3fea1eb4-b37e-4e06-b12a-f9b607165eb6"> 806 807 808 <div class="content"> 809 810 <div id="ageTab1" class="age1 row mx-xs-0 tab-padded tab-pane show active" role="tabpanel"> 811 <div class="col-xs-12 col-md-6 mb-xs-30 px-xs-0 centered"> 812 <h3 class="underline mx-auto">Uznapredovalost bolesti</h3> 813 <p class="small mb-xs-10">ViÅ¡e od 90% bolesnika kojima nije pružena medicinska pomoÄ, a boluju od SMA tipa 1, ne preživi ili zahtijeva stalnu respiratornu njegu do 2. godine života<sup>20</sup></p> 814 815<p class="small mb-xs-10">OdgaÄanje dijagnoze SMA tipa 1 može uzrokovati trajno oÅ¡teÄenje donjeg motoriÄkog neurona<sup>4</sup> te tako izravno utjecati na živÄano-miÅ¡iÄne funkcije pacijenta<sup>21</sup></p> 816 817<p class="small"><strong>VaÅ¡a brza reakcija i upuÄivanje na pružanje medicinske pomoÄi presudni
817su za zaustavljanje ili odgodu uznapredovalosti bolesti te omoguÄuje pacijentu najbolju dostupnu njegu<sup>4,10,22</sup></strong></p> 818 819 </div> 820 <div class=" col-xs-12 mb-xs-30 px-xs-0"> 821 822 <div data-animation-name="hcp-01-d-01" 823 data-loop="Off" 824 class="chart-img d-xs-none d-md-block my-xs-2 svg centered scroll-on-show is-visible" 825 title="Napredovanje spinalne miÅ¡iÄne atrofije (SMA) tip 1 u dojenÄadi 0-6 mjeseci"> 826 <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_1-CR_0.json"> 827 </div> 828 829 <div data-animation-name="hcp-01-m-01" 830 data-loop="Off" 831 class="chart-img d-xs-block d-md-none my-xs-2 svg centered scroll-on-show is-visible" 832 title="Napredovanje spinalne miÅ¡iÄne atrofije (SMA) tip 1 u dojenÄadi 0-6 mjeseci"> 833 <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_MOBILE_Graph_1-CR_0.json"> 834 </div> 835 836 837 <div class="row mx-xs-0"> 838 <div class="col-md-4 col-xs-12 px-xs-0 mb-md-0 mb-xs-4"> 839 <div class="snr-key"> 840 <div> 841 <div class="circle bg-sma-blue"></div> 842 <p class="smaller">Neuromuskularna kliniÄka istraživanja kod djece: Postotak preživljavanja oboljelih od SMA tipa 1*</p> 843 844 </div> 845 <div> 846 <div class="circle bg-sma-fuchsia"></div> 847 <p class="smaller">NeuroNext: Postotak preživljavanja oboljelih od SMA tipa 1*</p> 848 849 </div> 850 </div> 851 </div> 852 <div class="notes col-md-8 col-xs-12 px-xs-0 mb-xs-4"> 853 <p class="footnote pl-xs-0 pl-md-4">*Postotak preživljavanja bez težih posljedica prema neuromuskularnim kliniÄkim istraživanjima djece = nema smrtnosti i nema potrebe za â¥16 sati / dan neprekidnom respiratornom njegom u trajanju od 14 dana, ako se nije razvila akutna reverzibilna bolest;<sup>20</sup> n=23 (Pacijenti tipa 1 s 2 gena <em>SMN2</em>). Postotak preživljavanja prema NeuroNext = nema smrtnosti ni intubacije; n = 20<sup>21</sup></p> 854 855<p class="footnote pl-xs-0 pl-md-4">Izvori: Anderton RS i Mastaglia FL. 2015<sup>15</sup>, Finkel RS. 2013<sup>24</sup>, Finkel RS <em>i sur</em>. 2014<sup>20</sup> i Kolb SJ <em>i sur</em>. 2017<sup>21</sup></p> 856 857 </div> 858 </div> 859 </div> 860 </div> 861 862 </div> 863 </div> 864<div id="block-hcpagerange2" class="block block-block-content block-block-content7e38a2a1-ed49-4660-a22f-73ef2cb6d856"> 865 866 867 <div class="content"> 868 869 <div id="ageTab2" class="age2 row mx-xs-0 tab-padded tab-pane" role="tabpanel"> 870 <div class="col-lg-5 col-xs-12 pb-xs-20 px-xs-0 pr-md-4"> 871 <h3 class="underline">Uznapredovalost bolesti</h3> 872 <p class="small mb-xs-10">Iako pacijenti kojima je dijagnosticiran SMA tip 2 (izmeÄu 6â18 mjeseci života) u nekim sluÄajevima razviju motoriÄke sposobnosti u prvim godinama života, tijekom dugoroÄnijeg praÄenja pokazuju jasan i progresivan pad<sup>8</sup></p> 873 874<p class="small mb-xs-10">OdgaÄanjem dijagnoze SMA dolazi do trajnog oÅ¡teÄenja nižih motoriÄkih neurona,<sup>4</sup> Å¡to izravno utjeÄe na neuromuskularnu funkciju<sup>4,10,22</sup></p> 875 876<p class="small mb-xs-10"><strong>Pravovremeno upuÄivanje na lijeÄenje presudno je za zaustavljanje ili odgaÄanje uznapredovalosti bolesti i omoguÄuje pacijentu pristup najboljoj dostupnoj njezi<sup>4,10,22</sup></strong></p> 877 878 </div> 879 <div class="col-lg-7 col-xs-12 pb-xs-30 px-xs-0 pt-lg-60 pl-md-4"> 880 881 <div data-animation-name="hcp-02-d-01" 882 data-loop="Off" 883 class="chart-img d-xs-none d-md-block my-xs-2 svg centered scroll-on-show is-visible" 884 title="Spinalna miÅ¡iÄna atrofija (SMA) tip 2 napredovanje bolesti u dojenÄadi 6-18 mjeseci"> 885 <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_3-CR.json"> 886 </div> 887 888 <div data-animation-name="hcp-02-m-01" 889 data-loop="Off" 890 class="chart-img d-xs-block d-md-none my-xs-2 svg centered scroll-on-show is-visible" 891 title="Spinalna miÅ¡iÄna atrofija (SMA) tip 2 napredovanje bolesti u dojenÄadi 6-18 mjeseci"> 892 <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_MOBILE_Graph_3-CR.json"> 893 </div> 894 895 896 <div class="ml-xs-0 pl-md-9pc pl-xs-5pc"> 897 <p class="footnote mt-xs-10">
897TIMPSI: Test motoriÄkih sposobnosti novoroÄenÄadi</p> 898 899<p class="footnote mt-xs-2">Preuzeto iz Kolb SJ, <em>i sur</em>. 2017.<sup>21</sup></p> 900 901 </div> 902 </div> 903 </div> 904 905 </div> 906 </div> 907 908 </section> 909 910 911 912 </div> 913 </div> 914 </div> 915 </div> 916 917 918 <div class="container-fluid px-xs-0 bg-sma-turquoise-10 overflow-hide-x"> 919 <div class="container px-xs-0"> 920 921 922 <section class="region region-hcp-early-diag"> 923 <div id="block-importance" class="block block-block-content block-block-content33acb831-424f-40b6-af06-41fce39c7c6d"> 924 925 926 <div class="content"> 927 928 <div class="paragraph paragraph-medium paragraph-width-0 paragraph-blue py-xs-30 pb-xs-0 pb-md-30 row"> 929 <div class="col-xs-12 centered"> 930 <div class="top-hr bg-sma-turquoise-50"></div> 931 <h2 class="mb-md-30"> 932 <div class="clearfix text-formatted field field--name-field-importance-heading field--type-text field--label-hidden field__item">ZNAÄAJ RANE DIJAGNOZE</div> 933 </h2> 934 <p> 935 <div class="clearfix text-formatted field field--name-field-importance-text field--type-text-long field--label-hidden field__item"><p>Pravovremena dijagnoza SMA je od najveÄeg znaÄaja, jer su oÅ¡teÄenja neurona do kojih dolazi prije pružanja medicinske pomoÄi neizlijeÄiva<sup>4,5</sup></p> 936</div> 937 </p> 938 </div> 939 </div> 940 941 </div> 942 </div> 943<div id="block-hcpearliersignsofsma" class="block block-block-content block-block-content39248b85-1797-46dd-9128-55ac49ddee19"> 944 945 946 <div class="content"> 947 948 <div class="row mx-xs-0"> 949 <div class="col-xs-12 p-md-4 pt-xs-20 pb-xs-0 mx-md-auto mb-xs-0 mb-md-30 bg-white"> 950 <div class="row mx-auto mb-xs-0"> 951 <div class="col-lg-5 col-ds-6 col-xs-12 pt-md-20 pl-ds-50 pr-xs-0 pr-lg-4 small-container styled-list-container"> 952 <h3 class="underline">Pravovremena dijagnoza SMA presudna je za:<sup>25â27</sup></h3> 953 <ul class="styled-list"> 954 <li> 955 <p class="small">OdreÄivanje optimalne terapije i strategije borbe s boleÅ¡Äu</p> 956 </li> 957 <li> 958 <p class="small">OslobaÄanje pacijenta i njegovatelja od stresa i tereta</p> 959 </li> 960</ul> 961 962 <p class="note small mt-xs-30 mb-xs-20"><strong>Istraživanja sugeriraju da je pravovremena medicinska pomoÄ od najveÄe koristi za pacijente oboljele od SMA<sup>10,22,28</sup></strong></p> 963 964 </div> 965 <div class="col-lg-7 col-ds-6 col-xs-12 pt-md-20 pr-ds-50"> 966 <div data-animation-name="hcp-03-d-01" 967 data-loop="Off" 968 class="chart-img d-xs-block my-xs-2 svg centered scroll-on-show is-visible" 969 title="Vremenski okvir dijagnoze spinalne miÅ¡iÄne atrofije (SMA) tipa 1 u dojenÄadi 0-6 mjeseci"> 970 <img class="hidden" src="/sites/default/files/2021-10/107035_HCP_DESKTOP_Graph_2-CR.json"> 971 </div> 972 973 <p class="smallest mt-xs-10">Izvor: Serra-Juhe C i Tizzano EF, 2019<sup>19</sup></p> 974 975 </div> 976 </div> 977 <div class="row clip mb-xs-0 pb-md-40 py-xs-0 py-md-30"> 978 <div class="cta-row col-xs-12 mx-xl-auto pb-xs-20 mx-xs-0 px-xs-0"> 979 <div class="call-to-action" title="Rano djelovanje moglo bi ograniÄiti nepovratna oÅ¡teÄenja povezana sa SMA (4,5,10,29)"> 980 <span>PRAVOVREMENIM DJELOVANJEM SPRIJEÄIT ÄETE POJAVU NEIZLJEÄIVIH OÅ TEÄENJA KOJE UZROKUJE SMA<sup>4,5,10,29</sup></span> 981 <div class="clock scroll-on-show"></div> 982 </div> 983 </div> 984 </div> 985 </div> 986 </div> 987 988 </div> 989 </div> 990 991 </section> 992 993 994 995 </div> 996 </div> 997 998 999 <section class="region region-hcp-about-footer"> 1000 <div id="block-hcpaboutreferencesfooter" class="block block-block-content block-block-contentd9e8405c-7b4c-4c6d-b917-6ada19e2b704"> 1001 1002 1003 <div class="content"> 1004 1005 <div class="container-fluid px-0 references-container"> 1006 <div class="container"> 1007 <div class="references row mx-xs-0"> 1008 <div class="references-header col-xs-12 px-xs-0"> 1009 <div class="references-header-title"> 1010 <div class="references-toggle"></div> 1011 <p>Literatura</p> 1012 </div> 1013 </div> 1014 </div> 1015 </div> 1016 </div> 1017 1018 <div class="container-fluid px-0 bg-sma-turquoise-5 mb-xs-40"> 1019 <div class="container px-xs-0"> 1020 <div class="references row mx-xs-0"> 1021 <div class="col-xs-12"> 1022 <div class="row px-xs-0"> 1023 <div class="references-body col-xs-12 px-md-0 px-xs-0 text-sma-black-50"> 1024 <h6> 1025 <div class="clearfix text-formatted field field--name-field-reference-header field--type-text field--label-hidden field__item">Literatura</div> 1026 </h6> 1027 1028 <div class="clearfix text-formatted field field--name-field-reference-descri field--type-text-long field--label-hidden field__item"><ul> 1029 <li><strong>1.</strong> Kolb SJ i Kissel JT. <em>Klin. neurol.</em> 2015;33(4):831â46. </li> 1030 <li><strong>2.</strong> Prior TW, Leach ME, Finanger E. Spinalna miÅ¡iÄna atrofija. 24. veljaÄe 2000.g. [Ažurirano 14. studenoga 2019.g.]. Nalazi se u: Adam MP, Ardinger HH, Pagon RA, <em>i sur</em>. urednici. GeneReviews<sup>®</sup> [Internet]. Seattle (WA): SveuÄiliÅ¡te u Washingtonu, Seattle; 1993-2018.</li> 1031 <li><strong>3.</strong> Wang CH, <em>i sur</em>. <em>J DjeÄja neurol</em>. 2007;22(8):1027â49. </li> 1032 <li><strong>4.</strong> Govoni A <em>i sur</em>. <em>Mol Neurobiol</em>. 2018;55(8):6307â18. </li> 1033 <li><strong>5.</strong> Glascock J, <em>i sur</em>. <em>J Neuromuskularne bolesti</em> 2018;5(2):145â58. </li> 1034 <li><strong>6.</strong> Verhaart IEC <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2017;12:124. </li> 1035 <li><strong>7.</strong> Richter T, <em>i sur</em>. <em>Vrijednost zdravlja</em>. 2015;18(6):906â14. </li> 1036 <li><strong>8.</strong> Mercuri E <em>i sur</em>. <em>neurologija</em> 2019; 93 (13): e1241â7. </li> 1037 <li><strong>9.</strong> Mercuri E <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2020;15(1):84. </li> 1038 <li><strong>10.</strong> Schorling DC, <em>i sur</em>. <em>J Neuromuskularne bolesti</em> 2020;7:1â13.</li> 1039 <li><strong>11.</strong> D'Amico A <em>i sur</em>. <em>Orphanet J Rijetke bolesti</em> 2011;6:71. </li> 1040 <li><strong>12.</strong> Pobijedite SMA (2019). O SMA. Dostupno na: https://www.curesma.org/about-sma/. Pristupljeno: 19. listopad 2020.</li> 1041 <li><strong>13.</strong> Verhaart IEC <em>i sur</em>. <em>Dodatna datoteka</em> 2: Tablica S1. Pregled uÄestalosti pojavnosti SMA. Dodatak Verhaart IEC, i sur. Orphanet J Rijetke bolesti 2017;12:124. Dostupno na: https://ojrd.biomedcentral.com/articles/10.1186/s13023-017-0671-8. Pristupljeno: 19. listopad 2020.</li> 1042 <li><strong>14.</strong> Coovert DD, <em>i sur</em>. <em>Hum Mol Genet</em>. 1997;6(8):1205â14. </li> 1043 <li><strong>15.</strong> Anderton RS i Mastaglia FL. <em>StruÄna rev neuroter</em>. 2015;
104315:895â908. </li> 1044 <li><strong>16.</strong> Lefebvre S <em>i sur</em>. Cell. 1995;80:155â65. </li> 1045 <li><strong>17.</strong> Državni institut za zdravlje (NIH) (2020a). Literatura o genetici. VodiÄ kroz genetiku. <em>PMN1</em> gen. Dostupno na: https://ghr.nlm.nih.gov/gene/SMN1. Pristupljeno: 19. listopada 2020. </li> 1046 <li><strong>18.</strong> NIH (2020b). Literatura o genetici VodiÄ kroz genetiku. <em>PMN2</em> gen. Dostupno na: https://ghr.nlm.nih.gov/gene/SMN2. Pristupljeno: 19. listopada 2020.</li> 1047 <li><strong>19.</strong> Serra-Juhe C i Tizzano EF. <em>Eur J Human Genet</em>. 2019;27(12):1774â82. </li> 1048 <li><strong>20.</strong> Finkel RS <em>i sur</em>. <em>Neurologija</em> 2014;83(9):810â7. </li> 1049 <li><strong>21.</strong> Kolb SJ, <em>i sur</em>. <em>Ann Neurol</em>. 2017;82(6):883â91.</li> 1050 <li><strong>22.</strong> Kirschner J, <em>i sur</em>. <em>Eur J DjeÄja neurol</em>. 9. srpnja 2020.g.: S1090â3798 (20) 30142â2. Objavljeno na mreži prije ispisa.</li> 1051 <li><strong>23.</strong> Swoboda KJ, <em>i sur</em>. <em>Ann Neurol</em>. 2005;57(5):704â12. </li> 1052 <li><strong>24.</strong> Finkel RS. <em>Neuromuskularni poremeÄaji</em> 2013;23(2):112â5. </li> 1053 <li><strong>25.</strong> Qian Y, <em>i sur</em>. <em>BMC neurologija</em>. 2015;15:217. </li> 1054 <li><strong>26.</strong> Mammas IN and Spandidos DA. <em>StruÄna ter. med</em>. 2018;15:3673â9.</li> 1055 <li><strong>27.</strong> Lurio JG <em>i sur</em>. <em>Am Fam LijeÄnik</em>. 2015;91(1):38â44. </li> 1056 <li><strong>28.</strong> Waldrop MA i Elsheikh BH. <em>Klin. neurol</em>. 2020;38(3):505â18. </li> 1057 <li><strong>29.</strong> Lowes LP, <em>i sur</em>. <em>DjeÄja neurol</em>. 2019;98:39â45.</li> 1058</ul> 1059</div> 1060 1061 </div> 1062 </div> 1063 </div> 1064 </div> 1065 </div> 1066 </div> 1067 1068 </div> 1069 </div> 1070 1071 </section> 1072 1073 1074 1075 1076 <section class="region region-sma-page-footer"> 1077 <div id="block-hcppagefooter" class="block block-block-content block-block-contentbecf047f-ac3f-4693-945a-99f6e34c1581"> 1078 1079 1080 <div class="content"> 1081 1082 1083 <div class="container px-0 page-container"> 1084 1085 <footer class="footer row pb-xs-30 mx-xs-0"> 1086 1087 <div class="col-md-7 col-xs-12 px-xs-4 text-sma-black-50"> 1088 <img width="134" height="42" alt="" title="" src="/sites/default/files/2021-10/Signs%20of%20SMA_Croatia_GRAYSCALE.png" class="mb-xs-30"> 1089 <p class="small mb-xs-20">© 2021 Novartis Gene Therapies. Sva prava pridržana.</p> 1090 <p class="small mb-xs-10 text-sma-turquoise"> 1091 <a href="/sites/default/files/2021-10/Uvjeti_koristenja_ver1_HR_Terms%20of%20use_0.pdf" target="_blank" data-download="" title="" class="small"> 1092 Uvjeti koriÅ¡tenja</a> | 1093 <a href="/sites/default/files/2021-10/Privatnost_VER1_HR_Privacy_and_cookie_policy_0.pdf" target="_blank" data-download="" title="" class="small"> 1094 Pravila o zaÅ¡titi privatnosti i koriÅ¡tenje kolaÄiÄa</a> | 1095 <a href="#" id="custom-ot-sdk-btn" class="ot-sdk-show-settings small"> 1096 Cookie Settings 1097 </a> 1098 </p> 1099 <p class="small">HR2110138662 | Datum pripreme: listopad 2021</p> 1100 </div> 1101 <div class="col-md-5 col-xs-12 px-xs-4 mt-xs-20 mt-md-0 d-xs-flex justify-content-md-end justify-content-xs-center align-items-md-end"> 1102 <img width="184" height="30" alt="" title="" src="/sites/default/files/2021-02/novartis_logo_pos_RGB.png" class="align-left"> 1103 </div> 1104 1105 </footer> 1106 1107 </div> 1108 1109 <div class="modal-container"> 1110 <div id="hcpConfirmation" class="modal confirm"> 1111 <p><p>Ova Internet stranica je osmiÅ¡ljena kako bi vam pomogla uoÄiti rane simptome spinalne miÅ¡iÄne atrofije (SMA) i Å¡to uÄiniti ako ih uoÄite</p> 1112 1113<p>Ova je Internet stranica namijenjena samo zdravstvenim djelatnicima u EU. Please confirm you are a Healthcare Professional</p></p> 1114 <div id="hcpConfirmButton" class="btn btn-link -double -compact-xs" data-hide="#hcpConfirm" title=""> 1115 <div class="slider"> 1116 <div class="reveal"></div> 1117 </div> 1118 <div class="cover"></div>
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