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1<script type="application/ld+json">{"@context":"http://schema.org","@type":"MedicalCondition","name":"Duchenne Muscular Dystrophy","sameAs":"https://www.wikidata.org/wiki/Q1648484","code":"G71.01","recognizingAuthority":{"@type":"Organization","name":"PTC Therapeutics, Inc.","description":"Since 1998, PTC has been a biopharmaceutical company focused on innovative small molecule and gene therapies for rare genetic disorders. We operate offices and/or research labs in more than 20 countries and occupy a business footprint in more than 50 countries around the world. We also enjoy strong commercial performance and a robust capital position. Recently, we've expanded into oncology and virology therapeutic research.","url":"https://www.ptcbio.com/","brand":{"@type":"Brand","name":"EMFLAZA® (deflazacort)","alternateName":["EMFLAZA","deflazacort"],"sameAs":["https://en.wikipedia.org/wiki/Deflazacort"],"url":"https://www.emflaza.com/","logo":"https://www.emflaza.com/images/social-sharing.jpg"}}}</script>
1<script type="application/ld+json">{"@context":"http://schema.org","@type":"Drug","name":"EMFLAZA® (deflazacort)","sameAs":"https://en.wikipedia.org/wiki/Deflazacort","manufacturer":{"@type":"Organization","name":"PTC Therapeutics, Inc.","description":"Since 1998, PTC has been a biopharmaceutical company focused on innovative small molecule and gene therapies for rare genetic disorders. We operate offices and/or research labs in more than 20 countries and occupy a business footprint in more than 50 countries around the world. We also enjoy strong commercial performance and a robust capital position. Recently, we've expanded into oncology and virology therapeutic research.","url":"https://www.emflaza.com/"},"proprietaryName":"EMFLAZA","prescribingInfo":"https://www.emflaza.com/prescribing-information.pdf","prescriptionStatus":"PrescriptionOnly","warning":["INDICATION & IMPORTANT SAFETY INFORMATION FOR EMFLAZA® (deflazacort)","INDICATION","EMFLAZA® is indicated for the treatment of Duchenne muscular dystrophy 
1in patients 2 years of age and older.","IMPORTANT SAFETY INFORMATION","Contraindication: Do not use if you are allergic to deflazacort or any of the inactive ingredients in EMFLAZA.","Do not stop taking EMFLAZA, or change the amount you are taking, without first checking with your healthcare provider, as there may be a need for gradual dose reduction to decrease the risk of adrenal insufficiency and steroid withdrawal syndrome. Acute adrenal insufficiency can occur if corticosteroids are withdrawn abruptly, and can be fatal. A steroid withdrawal syndrome seemingly unrelated to adrenocortical insufficiency, may also occur following abrupt discontinuance of corticosteroids. For patients already taking corticosteroids during times of stress, the dosage may need to be increased.","Hyperglycemia: Corticosteroids can increase blood glucose, worsen pre-existing diabetes, predispose those on long-term treatment to diabetes mellitus, and may reduce the effect of anti-diabetic drugs. Monitor blood glucose at regular intervals. For patients with hyperglycemia, anti-diabetic treatment should be initiated or adjusted accordingly.","Increased Risk of Infection: Tell your healthcare provider if you have had recent or ongoing infections or if you have recently received a vaccine or are scheduled for a vaccination. Seek medical advice at once should you develop fever or other signs of infection, as some infections can potentially be severe and fatal. Avoid exposure to chickenpox or measles, but if you are exposed, medical advice should be sought without delay.","Alterations in Cardiovascular/Kidney Function: EMFLAZA can cause an increase in blood pressure, salt and water retention, or a decrease in your potassium and calcium levels. If this occurs, dietary salt restriction and potassium supplementation may be needed.","Behavioral and Mood Disturbances: There is a potential for severe behavioral and mood changes with EMFLAZA and you should seek medical attention if psychiatric symptoms develop.","Effects on Bones: There is a risk of osteoporosis or decrease in bone mineral density with prolonged use of EMFLAZA, which can potentially lead to vertebral and long bone fractures.","Effects on Growth and Development: Long-term use of corticosteroids, including EMFLAZA may slow growth and development in children.","Opthalmic Effects: EMFLAZA may cause cataracts, ocular infections and glaucoma and you should be monitored if corticosteroid therapy is continued for more than 6 weeks.","Vaccination: The administration of live or live attenuated vaccines is not recommended in patients on EMFLAZA. Live-attenuated or live vaccines can be administered at least 4 to 6 weeks prior to starting EMFLAZA.","Serious Skin Rashes: Seek medical attention at the first sign of a rash.","Drug Interactions: Certain medications can cause an interaction with EMFLAZA. Tell your healthcare provider of all the medicines you are taking, including over-the-counter medicines (such as insulin, aspirin or other NSAIDS), dietary supplements, and herbal products. Alternate treatment, dosage adjustment, and/or special test(s) may be needed during the treatment.","Common side effects that could occur with EMFLAZA include: Facial puffiness or Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, frequent daytime urination, unwanted hair growth, central obesity, and colds.","Please see the accompanying full Prescribing Information.","To report SUSPECTED ADVERSE REACTIONS, contact PTC Therapeutics, Inc. at 1-866-562-4620 or [email protected] or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch."]}</script>
1<script type="application/ld+json">{"@context":"http://schema.org","@type":"MedicalIndication","name":"INDICATION for EMFLAZA® (deflazacort)","description":"EMFLAZA® is indicated for the treatment of Duchenne muscular dystrophy in patients 2 years of age and older."}</script>
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.navigation ul li:nth-child(8){display:none}}header .navigation ul li:nth-child(6){--tw-bg-opacity:1;align-items:center;background-color:rgb(0 27 73/var(--tw-bg-opacity));flex-direction:row;position:relative}@media (min-width:1024px){header .navigation ul li:nth-child(6){justify-content:center}}@media(max-width:768px){header .navigation ul li:nth-child(6){margin-left:-1rem;margin-right:-1rem}}header .navigation ul li:nth-child(6) a{--tw-text-opacity:1;color:rgb(255 255 255/var(--tw-text-opacity));height:auto;position:relative}@media (min-width:1024px){header .navigation ul li:nth-child(6) a{position:static}}@media (min-width:768px){header .navigation ul li:nth-child(6) a{width:76%}}header .navigation ul li:nth-child(6) a.current-page-hover{--tw-bg-opacity:1;background-color:rgb(67 180 228/var(--tw-bg-opacity))}header .navigation ul li:nth-child(6) a.current-page-hover:before{left:0;right:0}@media (min-width:1024px){header .navigation ul li:nth-child(6) a.current-page-hover:before{bottom:0;display:block;margin:auto;padding-bottom:2.75rem;padding-top:2.75rem;top:0}}@media (min-width:768px){header .navigation ul li:nth-child(6) a:focus:before{bottom:0;display:block;left:-1.25rem;margin:auto;padding-bottom:2.75rem;padding-top:2.75rem;right:-1.25rem;top:0}}@media(max-width:1023px){header .navigation ul li:nth-child(6):after{display:none}}header .navigation ul li:nth-child(6):before{display:none}header .navigation ul li:nth-child(6):hover,header .navigation ul li:nth-child(6):hover:after{--tw-bg-opacity:1;background-color:rgb(67 180 228/var(--tw-bg-opacity))}header .navigation ul li:nth-child(6):hover a:after,header .navigation ul li:nth-child(6):hover a:before{display:none}header .navigation ul li a,header .navigation ul li button{display:inline-flex;font-family:Gotham,sans-serif;font-size:1rem;font-weight:700;height:100%;line-height:1.5rem;line-height:1.25;padding-top:.5rem;position:relative;z-index:10}@media (min-width:1024px){header .navigation ul li a,header .navigation ul li button{--tw-text-opacity:1;color:rgb(255 255 255/var(--tw-text-opacity))}}header .navigation ul li a.current-page-hover:before,header .navigation ul li a:focus:before,header .navigation ul li a:hover:before,header .navigation ul li a[aria-expanded=true]:before,header .navigation ul li button.current-page-hover:before,header .navigation ul li button:focus:before,header .navigation ul li button:hover:before,header .navigation ul li button[aria-expanded=true]:before{--tw-bg-opacity:1;background-color:rgb(67 180 228/var(--tw-bg-opacity));bottom:0;content:"";left:-1rem;position:absolute;right:-1rem;top:0;z-index:-5}@media (min-width:1024px){header .navigation ul li a.current-page-hover:before,header .navigation ul li a:focus:before,header .navigation ul li a:hover:before,header .navigation ul li a[aria-expanded=true]:before,header .navigation ul li button.current-page-hover:before,header .navigation ul li button:focus:before,header .navigation ul li button:hover:before,header .navigation ul li button[aria-expanded=true]:before{left:-.5rem;right:-.5rem}}@media (min-width:1200px){header .navigation ul li a.current-page-hover:before,header .navigation ul li a:focus:before,header .navigation ul li a:hover:before,header .navigation ul li a[aria-expanded=true]:before,header .navigation ul li button.current-page-hover:before,header .navigation ul li button:focus:before,header .navigation ul li button:hover:before,header .navigation ul li button[aria-expanded=true]:before{left:-1rem;right:-1rem}}@media (min-width:1280px){header .navigation ul li a.current-page-hover:before,header .navigation ul li a:focus:before,header .navigation ul li a:hover:before,header .navigation ul li a[aria-expanded=true]:before,header .navigation ul li button.current-page-hover:before,header .navigation ul li button:focus:before,header .navigation ul li button:hover:before,header .navigation ul li button[aria-expanded=true]:before{left:-1.5rem;right:-1.5rem}}header .navigation ul li button{--tw-text-opacity:1;color:rgb(2 117 168/var(--tw-text-opacity));padding-bottom:.5rem;padding-top:.5rem;text-align:left}@media (min-width:1024px){header .navigation ul li button{--tw-text-opacity:1;color:rgb(255 255 255/var(--tw-text-opacity));padding-left:.875rem;padding-right:.875rem}}@media (min-width:1280px){header .navigation ul li button{padding-left:0;padding-right:0}}header .navigation ul li button:after{border-left:7px solid transparent;border-right:7px solid transparent;border-top:8px solid #fff;content:"";height:0;position:absolute;right:0;top:.85rem;width:0}@media(max-width:1023px){header .navigation ul li button:after{--tw-border-opacity:1;border-top-color:rgb(2 117 168/var(--tw-border-opacity));border-top-width:8px}}header .navigation ul li button[aria-expanded=true]:after{transform:rotate(180deg)}@media(max-width:1023px){header .navigation ul li button.current-page-hover,header .navigation ul li button[aria-expanded=true]{--tw-text-opacity:1;color:rgb(255 255 255/var(--tw-text-opacity))}}@media(max-width:1194px){header .navigation ul li button{width:10rem}}header .navigation ul li ul{--tw-bg-opacity:1;align-items:flex-start;background-color:rgb(67 180 228/var(--tw-bg-opacity));display:flex;flex-direction:column;height:auto;justify-content:flex-start;left:-1rem;padding-left:0;padding-right:0;padding-top:.5rem;position:relative;width:100%;z-index:11}@media (min-width:1024px){header .navigation ul li ul{left:-.5rem;position:absolute;top:62px;width:calc(100% + .5rem - 2px)}}@media (min-width:1200px){header .navigation ul li ul{left:-1rem;width:calc(100% + 2rem)}}@media (min-width:1280px){header .navigation ul li ul{left:-1.5rem;width:calc(100% + 3rem)}}header .navigation ul li ul.kf-submenu--closed{display:none}header .navigation ul li ul.kf-submenu--open a{color:#fff}header .navigation ul li ul+li a.current-page-hover{background:red}header .navigation ul li ul li{margin-bottom:0;padding-left:1.5rem;padding-right:1.5rem}header .navigation ul li ul li:first-child,header .navigation ul li ul li:nth-child(2),header .navigation ul li ul li:nth-child(3),header .navigation ul li ul li:nth-child(4),header .navigation ul li ul li:nth-child(5),header .navigation ul li ul li:nth-child(6){min-height:auto;width:100%}header .navigation ul li ul li:after,header .navigation ul li ul li:before{display:none}header .navigation ul li ul li:hover{--tw-bg-opacity:1;background-color:rgb(2 117 168/var(--tw-bg-opacity))}header .navigation ul li ul li a{padding-bottom:.5rem;padding-top:.5rem;white-space:pre-wrap}header .navigation ul li ul li a sup{font-size:.5rem;top:0}header .navigation ul li ul li a:before{display:none}footer ul{padding-top:1.5rem}@media (min-width:768px){footer ul{display:grid;gap:1rem;grid-template-columns:repeat(4,minmax(0,1fr))}}@media (min-width:1280px){footer ul{align-items:center;display:flex;flex-wrap:wrap;gap:0;justify-content:space-between}}@media(max-width:767px){footer ul{display:flex;flex-direction:row;flex-wrap:wrap;justify-content:space-between}footer ul li:nth-child(3n-2){min-width:92px}footer ul li:nth-child(3n+2){min-width:110px}footer ul li:nth-child(3n){min-width:98px}footer ul .footer--last-list-item-row1,footer ul .footer--second-last-list-item{max-width:100px}}@media(max-width:374px){footer ul li:nth-child(3n-2){max-width:79px;min-width:79px}}footer ul li{padding-bottom:2rem}@media (min-width:1280px){footer ul li{padding-right:2.5rem}}@media (min-width:1920px){footer ul li{padding-right:3.5rem}}footer ul li.footer--last-list-item,footer ul li.footer--last-list-item-row1{padding-right:0}footer ul li a.link--white{border-bottom:1px solid #fff;text-decoration:none}@media(min-width:1200px){footer ul li.footer--second-last-list-item{max-width:210px}}@media(min-width:1900px){footer ul li.footer--second-last-list-item{max-width:230px}}.isi .isi__safety-information .bulleted-list li{margin-bottom:.5rem;padding-left:.75rem;position:relative}.isi .isi__safety-information .bulleted-list li:before{left:0;padding-left:0;padding-right:0;position:absolute;top:0}.isi sup{font-size:1em;top:0}.isi-copy-border .isi-copy-border--inner{align-items:center;display:flex;flex-direction:row;justify-content:flex-end;max-width:100%;padding-left:.5rem}@media (min-width:1280px){.isi-copy-border .isi-copy-border--inner{padding-left:4rem}}.isi-copy{padding-bottom:3rem}.isi-copy h2,.isi-copy h3{--tw-text-opacity:1;color:rgb(2 117 168/var(--tw-text-opacity));font-size:.875rem;font-weight:700;line-height:1.25rem}.isi-copy h2{margin-bottom:1rem}.isi-copy h3{margin-bottom:.5rem}.isi-copy p,.isi-copy ul li{margin-bottom:1rem}.isi-copy ul li{list-style-type:disc;margin-left:1rem}.sidebar{min-height:100%;position:absolute}.sidebar .kf-sticky__inner{margin-top:1rem;width:340px}.sidebar .kf-sticky{width:100%}.sidebar .kf-sticky .isi{--tw-border-opacity:1;--tw-bg-opacity:1;background-color:rgb(255 255 255/var(--tw-bg-opacity));border-color:rgb(2 117 168/var(--tw-border-opacity));border-width:1px;margin-bottom:1rem;margin-left:5px;max-width:330px;overflow-y:scroll;padding:1.5rem 1.25rem}.sidebar .kf-sticky .isi h2{font-size:1.125rem;line-height:1.75rem;line-height:1.25}.sidebar .prescription-btn{--tw-bg-opacity:1;--tw-text-opacity:1;align-items:center;background-color:rgb(0 27 73/var(--tw-bg-opacity));color:rgb(255 255 255/var(--tw-text-opacity));display:flex;font-family:Gotham,sans-serif;font-size:1rem;font-weight:700;justify-content:flex-start;letter-spacing:.5px;line-height:1.5rem;margin-bottom:.5rem;margin-left:5px;margin-right:5px;padding:.5rem 1.5rem}.sidebar .prescription-btn:focus,.sidebar .prescription-btn:hover{--tw-bg-opacity:1;background-color:rgb(67 180 228/var(--tw-bg-opacity))}.sticky-tray,.sticky-tray-ss{bottom:0;height:226px;left:0;position:fixed;right:0;transition:height .3s ease;z-index:10}
1.sticky-tray .kf-button,.sticky-tray-ss .kf-button{--tw-bg-opacity:1;--tw-text-opacity:1;background-color:rgb(2 117 168/var(--tw-bg-opacity));background-image:url(data:image/png;base64,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);background-position-x:calc(100% - 28px);background-position-y:center;background-repeat:no-repeat;background-size:12px 8px;color:rgb(255 255 255/var(--tw-text-opacity));font-weight:700;height:28px;text-align:left}.sticky-tray h2,.sticky-tray-ss h2{font-size:1.125rem;line-height:1.75rem;line-height:1.25;padding-right:1rem}.sticky-tray-ss{display:none}.resource-banner{font-family:Gotham,sans-serif;overflow:hidden;padding-bottom:3.75rem;position:relative}@media (min-width:1024px){.resource-banner{padding-bottom:0}}.resource-banner__close-btn{cursor:pointer;position:absolute;right:.5rem;top:.375rem;z-index:10}.resource-banner-img-circle{min-height:250px;position:relative}@media (min-width:1024px){.resource-banner-img-circle{min-height:198px}}@media (min-width:1280px){.resource-banner-img-circle{min-height:250px}}.resource-banner__circle{background-color:rgba(67,180,228,.1);border-radius:9999px;display:block;height:697px;left:-14.125rem;position:absolute;top:-27.438rem;width:697px}@media (min-width:1024px){.resource-banner__circle{height:344px;left:-83px;top:-4.375rem;width:344px}}@media (min-width:1280px){.resource-banner__circle{height:418px;left:-3.625rem;top:-4.375rem;width:418px}}.resource-banner__kids-image{left:.125rem;position:absolute;top:0;width:373px}@media (min-width:1024px){.resource-banner__kids-image{left:0;top:.5rem;width:267px}}@media (min-width:1280px){.resource-banner__kids-image{width:370px}}.resource-banner__content{padding-left:1.875rem;padding-right:1.875rem;padding-top:1.5rem;position:relative}@media (min-width:1280px){.resource-banner__content{width:69%}}@media (min-width:1024px){.resource-banner__content{margin-top:-10px;padding-bottom:0;padding-left:0;padding-top:0;width:63%}}@media screen and (min-width:1110px){.resource-banner__content{width:65%}}@media screen and (min-width:1250px){.resource-banner__content{width:70%}}@media (min-width:1440px){.resource-banner__content{margin-top:-.938rem;width:69%}}@media (min-width:1800px){.resource-banner__content{padding-left:0;padding-right:0;width:70%}}@media (min-width:1024px){.resource-banner__text-content{align-items:center;display:flex;margin-left:-30px;position:relative}}@media screen and (min-width:1250px){.resource-banner__text-content{margin-left:0}}.resource-banner__heading{--tw-text-opacity:1;color:rgb(31 52 97/var(--tw-text-opacity));font-size:1.75rem;font-weight:900;letter-spacing:-1.27px;line-height:2rem;margin-bottom:.875rem;text-transform:uppercase}@media (min-width:1024px){.resource-banner__heading{font-size:34px;letter-spacing:-1.4px;line-height:33px;margin-bottom:0;margin-top:-8px;max-width:649px}}@media (min-width:1280px){.resource-banner__heading{font-size:2.813rem;line-height:2.813rem;max-width:669px}}@media (min-width:1536px){.resource-banner__heading{font-size:3.125rem;line-height:3.25rem}}@media (min-width:1800px){.resource-banner__heading{font-size:53px;line-height:52px}}.resource-banner__text{--tw-text-opacity:1;color:rgb(19 29 71/var(--tw-text-opacity));font-size:1.25rem;line-height:1.438rem;margin-bottom:3.625rem}@media (min-width:1024px){.resource-banner__text{font-size:16px;line-height:1.25rem;margin-bottom:0;max-width:500px}}@media screen and (min-width:1200px){.resource-banner__text{font-size:1.125rem;line-height:1.75rem;line-height:21px}}@media (min-width:1280px){.resource-banner__text{font-size:1.625rem;line-height:1.75rem;max-width:534px}}@media (min-width:1800px){.resource-banner__text{max-width:466px}}.resource-banner__link{--tw-bg-opacity:1;--tw-text-opacity:1;background-color:rgb(31 52 97/var(--tw-bg-opacity));color:rgb(255 255 255/var(--tw-text-opacity));display:block;font-weight:700;padding:9px 1rem;text-align:center;text-transform:uppercase;width:232px}.resource-banner__link:focus,.resource-banner__link:hover{--tw-bg-opacity:1;background-color:rgb(67 180 228/var(--tw-bg-opacity))}@media (min-width:1024px){.resource-banner__link{margin-top:16px;padding:.625rem .75rem;width:187px}}@media (min-width:1440px){.resource-banner__link{margin-top:1.625rem;max-width:258px;padding-bottom:1rem;padding-top:1rem;width:100%}}.orange-horizontal-line{--tw-skew-x:60deg;--tw-bg-opacity:1;background-color:rgb(233 114 0/var(--tw-bg-opacity));bottom:0;height:1rem;left:0;position:absolute;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y));width:67.5%}@media (min-width:1024px){.orange-horizontal-line{max-width:1630px;width:83%}}@media (min-width:1800px){.orange-horizontal-line{max-width:1630px;width:1630px}}.orange-horizontal-line:before{--tw-bg-opacity:1;--tw-content:"";background-color:rgb(233 114 0/var(--tw-bg-opacity));bottom:0;content:var(--tw-content);display:block;height:1rem;left:-21px;position:absolute;width:100%}.modal{position:relative;z-index:99}.modal.modal_form ul li:before{--tw-text-opacity:1;color:rgb(233 114 0/var(--tw-text-opacity));content:"● ";display:inline-block;margin-left:-1em;width:1em}@media(max-width:375px){.modal.modal_form ul li:before{font-size:.65rem;position:relative;top:-.1rem}}.modal.modal_form .modal__overlay{background:rgba(0,0,0,.71);bottom:0;left:0;position:fixed;right:0;top:0;z-index:10}.modal.modal_form .modal__body{--tw-bg-opacity:1;background-color:rgb(255 255 255/var(--tw-bg-opacity));border-radius:10px;height:auto;max-height:90%;max-width:90%;overflow-y:auto;padding:19px 20px;position:fixed;right:50%;top:50%;transform:translate(50%,-50%);width:807px;z-index:20}.modal.modal_form .modal__body:focus{outline:1px dotted #000;outline-color:-webkit-focus-ring-color;outline-style:auto;outline-width:1px}.modal.modal_form .modal__body [data-close-modal]{background-color:transparent;border:2px solid #001b49;border-radius:100%;height:40px;position:absolute;right:20px;top:20px;width:40px}.modal.modal_form .modal__body [data-close-modal]:after,.modal.modal_form .modal__body 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var(--tw-space-x-reverse)));margin-right:calc(5rem*var(--tw-space-x-reverse))}.desktop\:space-x-0>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:calc(0px*(1 - var(--tw-space-x-reverse)));margin-right:calc(0px*var(--tw-space-x-reverse))}.desktop\:pt-0{padding-top:0}.desktop\:pl-8{padding-left:2rem}.desktop\:text-lg{font-size:1.125rem;line-height:1.75rem}.desktop\:leading-\[24px\]{line-height:24px}}@media (min-width:1536px){.\32xl\:mx-auto{margin-left:auto;margin-right:auto}}@media (min-width:1800px){.\33xl\:left-\[263px\]{left:263px}.\33xl\:-bottom-\[35px\]{bottom:-35px}.\33xl\:-right-5{right:-1.25rem}.\33xl\:mb-64{margin-bottom:16rem}.\33xl\:inline{display:inline}.\33xl\:w-\[184px\]{width:184px}}@media (min-width:1920px){.\34xl\:justify-start{justify-content:flex-start}.\34xl\:space-x-16>:not([hidden])~:not([hidden]){--tw-space-x-reverse:0;margin-left:calc(4rem*(1 - var(--tw-space-x-reverse)));margin-right:calc(4rem*var(--tw-space-x-reverse))}}.page--404 main{position:relative}.page--404 main .container{min-height:35rem}@media (min-width:768px){.page--404 main .container{min-height:40rem}}@media (min-width:1440px){.page--404 main .container{min-height:70rem}}.page--404 main .container .heading{font-size:1.875rem;line-height:2.25rem}@media (min-width:768px){.page--404 main .container .heading{font-size:4rem;line-height:4rem;padding-top:5rem}}.page--404 main .container .heading span{font-size:3.438rem}@media (min-width:768px){.page--404 main .container .heading span{font-size:7.813rem}}.page--404 main .bg--blue{bottom:0;min-height:15rem;position:absolute;width:100%;z-index:-5}@media (min-width:1024px){.page--404 main .bg--blue{min-height:30rem}}@media (min-width:1440px){.page--404 main .bg--blue{min-height:45rem}}.page--404 main .bg--blue{background-image:linear-gradient(167deg,transparent 49.8%,#e6f1f6 0)}.page--about-emflaza .section-help-boys .not-actual-patient{bottom:1rem;line-height:.75rem;position:absolute;right:25%}@media (min-width:640px){.page--about-emflaza .section-help-boys .not-actual-patient{bottom:1rem;max-width:4.188rem}}@media (min-width:768px){.page--about-emflaza .section-help-boys .not-actual-patient{max-width:none}}.page--about-emflaza .section-help-boys .heading-bg{background-image:url(data:image/png;base64,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.kf-accordion{margin-top:0}.page--about-emflaza .section-help-support .accordion .acc-inner .kf-accordion h3.kf-accordion__trigger{--tw-translate-x:7rem;--tw-translate-y:-4.5rem;display:inline-block;transform:translate(var(--tw-translate-x),var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}@media (min-width:768px){.page--about-emflaza .section-help-support .accordion .acc-inner .kf-accordion h3.kf-accordion__trigger{transform:none}}.page--about-emflaza .section-help-support .accordion .acc-inner .kf-accordion .kf-accordion__panel{background:rgba(67,180,228,.1);margin-top:0}@media (min-width:768px){.page--about-emflaza .section-help-support .accordion .acc-inner .kf-accordion .kf-accordion__panel{margin-top:1.25rem}}.page--about-emflaza .section-help-support .accordion .acc-inner .kf-accordion .kf-accordion__panel[data-state=expanded]{margin-bottom:5rem}@media 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.sitemap-poly{left:-.25rem;top:12.5rem}}@media (min-width:1024px){.page--sitemap main .sitemap-poly{height:28rem;top:11.5rem}}@media (min-width:1280px){.page--sitemap main .sitemap-poly{top:12rem}}.page--sitemap main .sitemap-poly .image,.page--sitemap main .sitemap-poly .image .gatsby-image-wrapper{height:100%}.page--sitemap main 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var(--tw-space-y-reverse)))}.page--safety-profile .section-1 .heading{padding-left:0;padding-right:0}@media (min-width:768px){.page--safety-profile .section-1 .heading{padding-left:0;padding-right:0}}.page--safety-profile .bulleted-list{font-family:Gotham,sans-serif}.page--safety-profile .bulleted-list .bullet-list-item{display:flex;font-weight:500;padding-bottom:.25rem;padding-top:.75rem}.page--safety-profile .bulleted-list.sublist-no-bullet>
1li:not(.bullet-list-item){padding-bottom:0}.page--safety-profile .bulleted-list.sublist-no-bullet>li:not(.bullet-list-item):before{content:"";padding:0}.page--safety-profile .circled-list li{display:flex;margin-left:2rem}.page--safety-profile .circled-list li:before{content:"◦"}.page--safety-profile .whizzbang{right:10px;top:-8px;transform-origin:bottom;width:160px}@media (min-width:1280px){.page--safety-profile .whizzbang{right:390px;top:0;width:330px}}@media (min-width:1800px){.page--safety-profile .whizzbang{right:275px}}.page--safety-profile .whizzbang .image{position:absolute}.page--safety-profile .accordion{margin-bottom:0}@media (min-width:768px){.page--safety-profile .accordion{margin-bottom:1.5rem;margin-top:3rem}}.page--safety-profile .accordion .acc-inner{display:flex;margin-top:.75rem}@media (min-width:640px){.page--safety-profile .accordion .acc-inner{margin-top:1.75rem}}.page--safety-profile .accordion .acc-inner .kf-accordion{margin-top:0}.page--safety-profile 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li:before{padding-left:0}.page--transcript.page--transcript-efficacydeepdives .script-content h2{--tw-text-opacity:1;color:rgb(233 114 0/var(--tw-text-opacity));font-size:1.125rem;font-weight:700;line-height:1.75rem;margin-bottom:1rem}.page--transcript.page--transcript-efficacydeepdives .script-content p:not(:last-of-type){margin-bottom:1rem}.page--transcript.page--transcript-efficacydeepdives .script-content .voice-title{--tw-text-opacity:1;color:rgb(2 117 168/var(--tw-text-opacity));font-family:Gotham,sans-serif;font-weight:700}.page--transcript.page--transcript-efficacydeepdives .script-content .script-blue-divider{--tw-bg-opacity:1;background-color:rgb(0 27 73/var(--tw-bg-opacity));height:1px;margin-bottom:2rem;margin-top:2rem;width:100%}@media (min-width:1024px){.page--transcript.page--transcript-efficacydeepdives .script-content .script-blue-divider{margin-bottom:3rem;margin-top:3rem}}.dosing-calc{border-color:#88888b}.dosing-calc-form h4,.dosing-calc-form 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1<a href="/understanding-dispense-as-written.pdf" class="resource-banner__link" target="_blank" rel="noopener noreferrer"><span class="text-center text-base leading-[0] lg:text-[17px]">SEE THE FAQ</span></a></div></div><img 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1Doctor Discussion Guide</a></li><li class="kf-submenu-li kf-menu-link-video-library"><a href="/video-library" aria-current="page">Video Library</a></li></ul></li><li class="kf-menu-link kf-menu-link-es"><a href="/es">Información en Español</a></li><li class="kf-menu-link "><a href="https://hcp.emflaza.com/">HCP Site</a></li><li class="kf-menu-link "><a href="/prescription-start-form.pdf">Prescription Start Form</a></li></ul></nav></div></div></div></header><main id="content"><section class="relative"><div class="bg-1-image"><div class="image"></div></div><div class="container container--inner"><div class="max-w-3xl"><div class="kf-heroUtility heading heading-hero-blue"><h1>Contact Us</h1></div><div class="mb-9"><h2 class="orange-heading uppercase my-5 md:my-0 md:mb-5 md:text-left">For inquiries pertaining to emflaza</h2><p class="mb-3 lg:mb-7">For medical information, product complains, or to report an adverse event, please call <a class="kf-anchorlink link underline" href="tel:18665624620" target="_blank" rel="">1‑866‑562‑4620</a> or email at <a class="kf-anchorlink link underline" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a>.</p><p>You may also report side effects to FDA at <a class="kf-anchorlink link underline" href="tel:18003321088" target="_blank" rel="">1‑800‑FDA‑1088</a> or at <a href="https://www.fda.gov/medwatch" target="_blank" rel="noreferrer" class="link underline">www.fda.gov/medwatch</a>.</p></div><div class=" mb-9"><h2 class="orange-heading uppercase my-5 md:my-0 md:mb-5 md:text-left">PTC <span class="italic">Cares</span><sup>™</sup> support program</h2><p class="mb-3 lg:mb-7">PTC <span class="italic">Cares</span> is a support program designed to help you get your child started on treatment, continue treatment uninterrupted, and support you throughout the treatment journey.</p><div class="flex flex-col"><div class="flex space-x-1"><span class="font-bold">Phone: </span> <a class="kf-anchorlink link underline" href="tel:18444782227" target="_blank" rel="">1‑844‑478‑2227</a></div><div class="flex space-x-1"><span class="font-bold">Site: </span> <a class="kf-anchorlink link underline" href="https://ptccares.com/" target="_blank" rel="">ptccares.com</a></div></div></div><div class=" mb-9"><h2 class="orange-heading uppercase my-5 md:my-0 md:mb-5 md:text-left">PTC peer navigator program</h2><p class="mb-3 lg:mb-7">This program connects you with other families familiar with EMFLAZA who can provide you with the support and guidance you need to better understand your child&#x27;s treatment options. To be connected with a PTC Peer Navigator, email <a class="kf-anchorlink link underline" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a> or call <a class="kf-anchorlink link underline" href="tel:18662825873" target="_blank" rel="">1‑866‑282‑5873</a>.</p></div><div class="pb-8  mb-9 md:pb-0"><h2 class="orange-heading uppercase my-5 md:my-0 md:mb-5 md:text-left">Corporate headquarters</h2><div class="mb-4"><span class="text-emflaza-blue-200 font-bold">PTC Therapeutics Inc.</span><br/><span>500 Warren Corporate Center Drive</span><br/><span>Warren, NJ 07059</span><br/><div class="flex space-x-1"><span class="font-bold">Phone: </span> <a class="kf-anchorlink link underline" href="tel:9082227000" target="_blank" rel="">908‑222‑7000</a></div><div class="flex space-x-1"><span class="font-bold">Fax: </span> <a class="kf-anchorlink link underline" href="tel:9082227231" target="_blank" rel="">908‑222‑7231</a></div></div><div><div class="flex space-x-1"><span class="font-bold">For general inquiries:</span> <a class="kf-anchorlink link underline" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a></div><div class="flex space-x-1"><span class="font-bold">For patients and families:</span> <a class="kf-anchorlink link underline" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a></div><div class="flex space-x-1"><span class="font-bold">For physicians:</span> <a class="kf-anchorlink link underline" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a></div></div></div></div></div><div class="bg-bottom hidden lg:block"><div class="image"></div></div></section></main><div class="opacity-0"><div class="sticky-tray block"><button class="kf-button container kf-button" type="button">Important Safety Information and Indication</button><div class="container pt-6 bg-white"><div class="isi font-gotham"><h2 class="mb-4 font-bold uppercase text-emflaza-blue-200">Indication &amp; Important Safety Information for EMFLAZA<sup>®</sup> <span class="lowercase">(deflazacort)</span></h2><div class="isi__safety-information"><h3 class="mb-1 font-bold text-emflaza-blue-200">When should I not take<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">Do not use if you have had hypersensitivity, including allergic reactions, to deflazacort or any of the inactive ingredients.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What warnings should I know about<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><ul class="mt-3 mb-4 bulleted-list"><li>EMFLAZA can cause changes in endocrine function. Do not stop taking EMFLAZA, or change the amount you are taking, without first checking with your healthcare provider, as there may be a need for gradual dose reduction to decrease the risk of adrenal insufficiency and steroid “withdrawal syndrome”. Acute adrenal insufficiency can occur if corticosteroids are withdrawn abruptly, and can be fatal. A steroid “withdrawal syndrome,” seemingly unrelated to adrenocortical insufficiency, may al
1so occur following abrupt discontinuance of corticosteroids. For patients already taking corticosteroids during times of stress, the dosage may need to be increased.</li><li>There is an increased risk of infection when taking EMFLAZA. Tell the healthcare provider if the patient has had recent or ongoing infections or if they have recently received a vaccine. Medical advice should be sought immediately if the patient develops fever or other signs of infection. Patients and/or caregivers should be made aware that some infections can potentially be severe and fatal. Warn patients who are on corticosteroids to avoid exposure to chickenpox or measles and to alert their healthcare provider immediately if they are exposed.</li><li>EMFLAZA can cause an increase in blood pressure and water retention. If this occurs, dietary salt restriction and potassium supplementation may be needed.</li><li>There is an increased risk of developing a hole in the stomach or intestines in patients with certain stomach or intestine disorders when taking corticosteroids like EMFLAZA.<!-- --> </li><li>EMFLAZA can cause severe behavioral and mood changes. Seek medical attention from the health care provider if any behavioral or mood changes develop.</li><li>There is a risk of osteoporosis with prolonged use of EMFLAZA, which can lead to vertebral and long bone fractures.</li><li>EMFLAZA may cause cataracts or glaucoma and a health care provider should monitor for these conditions if corticosteroid therapy is continued for more than 6 weeks.</li><li>Immunizations should be up-to-date according to immunization guidelines prior to starting therapy with EMFLAZA. Live‑attenuated or live vaccines should be administered at least 4 to 6 weeks prior to starting EMFLAZA. Live‑attenuated or live vaccines should not be used in patients taking EMFLAZA.</li><li>EMFLAZA can cause serious skin rashes. Seek medical attention at the first sign of a rash.</li><li>Rare instances of anaphylaxis have occurred in patients receiving corticosteroid therapy, including EMFLAZA.</li></ul><h3 class="mb-1 font-bold text-emflaza-blue-200">What should I tell my health care provider?</h3><p>Tell the health care provider about all medical conditions, including if the patient:</p><ul class="mt-3 mb-4 bulleted-list"><li>is pregnant or planning to become pregnant. EMFLAZA<sup>®</sup> (deflazacort) can harm your unborn baby.<!-- --> </li><li>is breastfeeding or planning to breastfeed. EMFLAZA may appear in breastmilk and could affect a nursing child.</li></ul><p class="mb-4">Certain medications can cause an interaction with EMFLAZA. Tell your healthcare provider of all the medicines you are taking, including over-the-counter medicines (such as insulin, aspirin or other NSAIDS), dietary supplements, and herbal products. Alternate treatment, dosage adjustment, and/or special test(s) may be needed during the treatment.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What are the side effects of<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">The most common side effects of EMFLAZA include facial puffiness or Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, frequent daytime urination, unwanted hair growth, central obesity, and colds. These are not all of the possible side effects of EMFLAZA. Call your doctor for medical advice about side effects.</p><p><strong>To report an adverse event, please call<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18665624620" target="_blank" rel="">1-866-562-4620</a> <!-- -->or email at<!-- --> <a class="kf-anchorlink link link--light-blue" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a>. You may also report side effects to FDA at<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18003321088" target="_blank" rel="">1-800-FDA-1088</a> <!-- -->or at<!-- --> <a href="https://www.fda.gov/medwatch" target="_blank" rel="noreferrer" class="link link--light-blue">www.fda.gov/medwatch</a>.</strong></p></div></div></div></div><div class="sticky-tray-ss"><button class="kf-button container kf-button" type="button">Important Safety Information and Indication</button><div class="container pt-6 bg-white"><div class="isi font-gotham"><h2 class="mb-4 font-bold uppercase text-emflaza-blue-200">Indication &amp; Important Safety Information for EMFLAZA<sup>®</sup> <span class="lowercase">(deflazacort)</span></h2><div class="isi__safety-information"><h3 class="mb-1 font-bold text-emflaza-blue-200">When should I not take<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">Do not use if you have had hypersensitivity, including allergic reactions, to deflazacort or any of the inactive ingredients.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What warnings should I know about<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><ul class="mt-3 mb-4 bulleted-list"><li>EMFLAZA can cause changes in endocrine function. Do not stop taking EMFLAZA, or change the amount you are taking, without first checking with your healthcare provider, as there may be a need for gradual dose reduction to decrease the risk of adrenal insufficiency and steroid “withdrawal syndrome”. Acute adrenal insufficiency can occur if corticosteroids are withdrawn abruptly, and can be fatal. A steroid “withdrawal syndrome,” seemingly unrelated to adrenocortical insufficiency, may al
1so occur following abrupt discontinuance of corticosteroids. For patients already taking corticosteroids during times of stress, the dosage may need to be increased.</li><li>There is an increased risk of infection when taking EMFLAZA. Tell the healthcare provider if the patient has had recent or ongoing infections or if they have recently received a vaccine. Medical advice should be sought immediately if the patient develops fever or other signs of infection. Patients and/or caregivers should be made aware that some infections can potentially be severe and fatal. Warn patients who are on corticosteroids to avoid exposure to chickenpox or measles and to alert their healthcare provider immediately if they are exposed.</li><li>EMFLAZA can cause an increase in blood pressure and water retention. If this occurs, dietary salt restriction and potassium supplementation may be needed.</li><li>There is an increased risk of developing a hole in the stomach or intestines in patients with certain stomach or intestine disorders when taking corticosteroids like EMFLAZA.<!-- --> </li><li>EMFLAZA can cause severe behavioral and mood changes. Seek medical attention from the health care provider if any behavioral or mood changes develop.</li><li>There is a risk of osteoporosis with prolonged use of EMFLAZA, which can lead to vertebral and long bone fractures.</li><li>EMFLAZA may cause cataracts or glaucoma and a health care provider should monitor for these conditions if corticosteroid therapy is continued for more than 6 weeks.</li><li>Immunizations should be up-to-date according to immunization guidelines prior to starting therapy with EMFLAZA. Live‑attenuated or live vaccines should be administered at least 4 to 6 weeks prior to starting EMFLAZA. Live‑attenuated or live vaccines should not be used in patients taking EMFLAZA.</li><li>EMFLAZA can cause serious skin rashes. Seek medical attention at the first sign of a rash.</li><li>Rare instances of anaphylaxis have occurred in patients receiving corticosteroid therapy, including EMFLAZA.</li></ul><h3 class="mb-1 font-bold text-emflaza-blue-200">What should I tell my health care provider?</h3><p>Tell the health care provider about all medical conditions, including if the patient:</p><ul class="mt-3 mb-4 bulleted-list"><li>is pregnant or planning to become pregnant. EMFLAZA<sup>®</sup> (deflazacort) can harm your unborn baby.<!-- --> </li><li>is breastfeeding or planning to breastfeed. EMFLAZA may appear in breastmilk and could affect a nursing child.</li></ul><p class="mb-4">Certain medications can cause an interaction with EMFLAZA. Tell your healthcare provider of all the medicines you are taking, including over-the-counter medicines (such as insulin, aspirin or other NSAIDS), dietary supplements, and herbal products. Alternate treatment, dosage adjustment, and/or special test(s) may be needed during the treatment.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What are the side effects of<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">The most common side effects of EMFLAZA include facial puffiness or Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, frequent daytime urination, unwanted hair growth, central obesity, and colds. These are not all of the possible side effects of EMFLAZA. Call your doctor for medical advice about side effects.</p><p><strong>To report an adverse event, please call<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18665624620" target="_blank" rel="">1-866-562-4620</a> <!-- -->or email at<!-- --> <a class="kf-anchorlink link link--light-blue" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a>. You may also report side effects to FDA at<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18003321088" target="_blank" rel="">1-800-FDA-1088</a> <!-- -->or at<!-- --> <a href="https://www.fda.gov/medwatch" target="_blank" rel="noreferrer" class="link link--light-blue">www.fda.gov/medwatch</a>.</strong></p></div></div></div></div><div id="isi" class="inner-isi"><a href="/prescription-start-form.pdf" target="_blank" class="prescription-btn"><img src="/images/icons/icon-prescription.png" alt="" class="icon_prescription" width="45" height="45"/>
1<span>Prescription Start Form</span></a><div class="container mt-4 mb-7"><div class="isi font-gotham"><h2 class="mb-4 font-bold uppercase text-emflaza-blue-200">Indication &amp; Important Safety Information for EMFLAZA<sup>®</sup> <span class="lowercase">(deflazacort)</span></h2><div class="isi__indication mb-4 block"><h3 class="mb-1 font-bold text-emflaza-blue-200">What is<!-- --> <span class="uppercase">EMFLAZA<sup>®</sup></span> <!-- -->(deflazacort) used for?</h3><p>EMFLAZA is a prescription medicine used to treat Duchenne muscular dystrophy (DMD) in patients 2 years of age and older.</p></div><div class="isi__safety-information"><h3 class="mb-1 font-bold text-emflaza-blue-200">When should I not take<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">Do not use if you have had hypersensitivity, including allergic reactions, to deflazacort or any of the inactive ingredients.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What warnings should I know about<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><ul class="mt-3 mb-4 bulleted-list"><li>EMFLAZA can cause changes in endocrine function. Do not stop taking EMFLAZA, or change the amount you are taking, without first checking with your healthcare provider, as there may be a need for gradual dose reduction to decrease the risk of adrenal insufficiency and steroid “withdrawal syndrome”. Acute adrenal insufficiency can occur if corticosteroids are withdrawn abruptly, and can be fatal. A steroid “withdrawal syndrome,” seemingly unrelated to adrenocortical insufficiency, may also occur following abrupt discontinuance of corticosteroids. For patients already taking corticosteroids during times of stress, the dosage may need to be increased.</li><li>There is an increased risk of infection when taking EMFLAZA. Tell the healthcare provider if the patient has had recent or ongoing infections or if they have recently received a vaccine. Medical advice should be sought immediately if the patient develops fever or other signs of infection. Patients and/or caregivers should be made aware that some infections can potentially be severe and fatal. Warn patients who are on corticosteroids to avoid exposure to chickenpox or measles and to alert their healthcare provider immediately if they are exposed.</li><li>EMFLAZA can cause an increase in blood pressure and water retention. If this occurs, dietary salt restriction and potassium supplementation may be needed.</li><li>There is an increased risk of developing a hole in the stomach or intestines in patients with certain stomach or intestine disorders when taking corticosteroids like EMFLAZA.<!-- --> </li><li>EMFLAZA can cause severe behavioral and mood changes. Seek medical attention from the health care provider if any behavioral or mood changes develop.</li><li>There is a risk of osteoporosis with prolonged use of EMFLAZA, which can lead to vertebral and long bone fractures.</li><li>EMFLAZA may cause cataracts or glaucoma and a health care provider should monitor for these conditions if corticosteroid therapy is continued for more than 6 weeks.</li><li>Immunizations should be up-to-date according to immunization guidelines prior to starting therapy with EMFLAZA. Live‑attenuated or live vaccines should be administered at least 4 to 6 weeks prior to starting EMFLAZA. Live‑attenuated or live vaccines should not be used in patients taking EMFLAZA.</li><li>EMFLAZA can cause serious skin rashes. Seek medical attention at the first sign of a rash.</li><li>Rare instances of anaphylaxis have occurred in patients receiving corticosteroid therapy, including EMFLAZA.</li></ul><h3 class="mb-1 font-bold text-emflaza-blue-200">What should I tell my health care provider?</h3><p>Tell the health care provider about all medical conditions, including if the patient:</p><ul class="mt-3 mb-4 bulleted-list"><li>is pregnant or planning to become pregnant. EMFLAZA<sup>®</sup> (deflazacort) can harm your unborn baby.<!-- --> </li><li>is breastfeeding or planning to breastfeed. EMFLAZA may appear in breastmilk and could affect a nursing child.</li></ul><p class="mb-4">Certain medications can cause an interaction with EMFLAZA. Tell your healthcare provider of all the medicines you are taking, including over-the-counter medicines (such as insulin, aspirin or other NSAIDS), dietary supplements, and herbal products. Alternate treatment, dosage adjustment, and/or special test(s) may be needed during the treatment.</p><h3 class="mb-1 font-bold text-emflaza-blue-200">What are the side effects of<!-- --> <span class="uppercase">EMFLAZA</span>?</h3><p class="mb-4">The most common side effects of EMFLAZA include facial puffiness or Cushingoid appearance, weight increased, increased appetite, upper respiratory tract infection, cough, frequent daytime urination, unwanted hair growth, central obesity, and colds. These are not all of the possible side effects of EMFLAZA. Call your doctor for medical advice about side effects.</p><p><strong>To report an adverse event, please call<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18665624620" target="_blank" rel="">1-866-562-4620</a> <!-- -->or email at<!-- --> <a class="kf-anchorlink link link--light-blue" href="mailto:[email protected]" target="_blank" rel="">[email protected]</a>. You may also report side effects to FDA at<!-- --> <a class="kf-anchorlink link link--light-blue" href="tel:18003321088" target="_blank" rel="">1-800-FDA-1088</a> <!-- -->or at<!-- --> <a href="https://www.fda.gov/medwatch" target="_blank" rel="noreferrer" class="link link--light-blue">www.fda.gov/medwatch</a>.</strong></p></div></div></div></div></div><footer class="p-6 text-white bg-emflaza-blue-200" lang="en"><div class="md:container xl:pl-12 2xl:mx-auto"><ul><li><a class="link link--white font-gotham font-bold" href="/">Homepage</a></li><li><a class="link link--white font-gotham font-bold" href="/understanding-corticosteroids">Understanding<br class="sm:hidden"/> Corticosteroids</a></li><li><a class="link link--white font-gotham font-bold" href="/about-emflaza">About<br class="sm:hidden"/> EMFLAZA</a></li><li><a class="link link--white font-gotham font-bold" href="/safety">Safety</a></li><li><a class="link link--white font-gotham font-bold" href="/dosing">Dosing</a></li><li><a class="link link--white font-gotham font-bold" href="/ptc-cares-helps">PTC <span class="italic">Cares</span><sup>TM</sup></a></li><li><a class="link link--white font-gotham font-bold" href="/caregiver-resources">Caregiver<br class="sm:hidden"/> Resources</a></li><li class="footer--last-list-item-row1"><a class="link link--white font-gotham font-bold" href="/doctor-discussion-guide">
1Doctor Discussion Guide</a></li><li><a class="link link--white font-gotham font-bold" href="/video-library">Video Library</a></li><li><a lang="es" class="link link--white font-gotham font-bold" href="/es">Información<br class="sm:hidden"/> en Español</a></li><li><a class="link link--white font-gotham font-bold" href="/sign-up-for-updates">Sign up for<br class="sm:hidden"/> Updates</a></li><li><a aria-current="page" class="link link--white font-gotham font-bold" href="/contact-us">Contact Us</a></li><li><a class="kf-anchorlink link link--white font-gotham font-bold" href="https://www.ptcbio.com/terms-of-use" target="_blank" rel="noopener noreferrer">Terms of Use</a></li><li><a class="kf-anchorlink link link--white font-gotham font-bold" href="https://www.ptcbio.com/privacy-statement" target="_blank" rel="noopener noreferrer">Privacy Policy</a></li><li class="footer--second-last-list-item"><a class="link link--white font-gotham font-bold" href="/cookie-policy">Do Not Sell or Share My Personal Information</a></li><li class="footer--last-list-item"><a class="link link--white font-gotham font-bold" href="/sitemap">Sitemap</a></li></ul><div class="mt-3 mb-5 md:flex md:mt-0 items-end"><div class="text-xs font-gotham font-medium md:flex-1 md:pt-3"><p>This site is intended for US audiences only.</p><p class="mt-3">PTC <span class="italic">Cares</span>™ is a trademark of PTC Therapeutics, Inc.<br/>Emflaza<sup class="text-lg leading-3 top-0">®</sup> is a registered trademark of PTC Therapeutics, Inc.<br/>© 2023 PTC Therapeutics, Inc. All Rights Reserved.</p><p>US-EMF-0299v6 10/23</p></div><div class="md:flex-1 md:text-right"><a class="kf-anchorlink inline-block mt-12 md:mt-0 z-0 relative" href="https://www.ptcbio.com/our-company/about" target="_blank" rel="noopener noreferrer"><span class="sr-only">PTC Therapeutics homepage</span><span aria-hidden="true"><div class="image"></div></span></a></div></div></div></footer></div></div><div id="gatsby-announcer" style="position:absolute;top:0;width:1px;height:1px;padding:0;overflow:hidden;clip:rect(0, 0, 0, 0);white-space:nowrap;border:0" aria-live="assertive" aria-atomic="true"></div></div>
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