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The site you are linking to is not controlled or endorsed by GSK, and GSK is not responsible for the content provided on that site.</p> 3907</div></div><div class="sc-keZlUN cIVhNf"><div rendertype="button" iconposition="left" icon="" text="Go Back" buttonoptions="[object Object]" linkoptions="[object Object]" textalignment="center" class="sc-dqLwBE hdnSiw ButtonContainerWrapper"><button renderType="button" iconPosition="left" text="Go Back" buttonOptions="[object Object]" linkOptions="[object Object]" textAlignment="center" data-link="true" data-link-name="Go Back" aria-label="Go Back" aria-disabled="false" role="button" tabindex="0" type="button" class="sc-eeufRq kvwOfi exitOverlayClose ButtonContainer closeBtn"><span class="sc-hDSWhm djXJlp">Go Back</span></button></div><div rendertype="buttonAsLink" iconposition="left" icon="" text="Continue" buttonoptions="[object Object]" linkoptions="[object Object]" textalignment="center" class="sc-dqLwBE hdnSiw ButtonContainerWrapper"><a 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gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 dark gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="left" class="sc-cQEGsf cOYBjS"><div width="none" test="true" contentalignment="left" class="sc-fByJgg fbUZmz richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="Dark"><h1>Safety</h1> 3908</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div scrollbarwidth="0" stickyheight="48" class="sc-hoMkd ilWVIE"><div id="sticky anchor links" data-component="sticky anchor links" data-component-id="sticky anchor links" class="sc-eEelSk fqykIe non_sticky_anchor_links bright " headeroffsettop="0" scrollbarwidth="0"><div scrollbarwidth="0" class="sc-fvfRmj fgHEWh"><button class="sc-dGVcAg cNbgiO"><span></span><i class="sc-kwjbRt fUibXr material-icons" size="24" color="secondary" weight="100"></i></button></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO dNbdXk default-class default-class rte-bg-alpha" scrollbarwidth="0" appliedclassnames="default-class default-class rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div class="sc-cQEGsf gSLDuy"><div test="true" class="sc-fByJgg lgFNkj richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div id="a1" class="sc-exWHUf lgMziP"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iCobsJ white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h2 class="rte-body-colored">Safety Profile</h2> 3909</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Divider" newstylesystemclass="" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/divider" background="noFill" scrollbarwidth="0" linestyle="solid" class="sc-htZDeQ cxRoya gsk-h-pt-20 gsk-h-pb-20 footer-divider"><div background="noFill" scrollbarwidth="0" class="sc-kNdzzL burgKR"><div parent="" linecolor="delta" class="sc-hSEhNS jbWfoB"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO ewXLuc white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3>PRIMA Clinical Study: An established safety and tolerability profile in 1L maintenance therapy of HRD-positive advanced ovarian cancer<sup>1,2</sup></h3> 3910</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iIKcvc white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3 class="rte-body-colored">ARs reported in â¥10% of all HRD-positive patients receiving ZEJULA in PRIMA<sup>1,a</sup></h3> 3911</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Content Card" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="item0,item1" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/content-card" al
3911ignment="center" class="sc-jnGlFn iOvhnB white " scrollbarwidth="0" appliedclassnames="white "><div alignment="center" scrollbarwidth="0" class="sc-gtgTTu kCPxiO"><div imagealignment="center" alignment="center" imageposition="belowTitle" class="sc-yAzml jCTBRV"><div alignment="center" imageposition="belowTitle" class="sc-iTwQZo dKOvfO"></div><div imageposition="belowTitle" imagesize="large" imagealignment="center" alignment="center" class="sc-fvXKBq dcHBsc"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-adverse-reactions-grades-1-4-and-3-4-mobile.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-adverse-reactions-grades-1-4%20and%203-4.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-adverse-reactions-grades-1-4%20and%203-4.jpg?auto=format" alt="Adverse reactions reported table" title="Adverse reactions reported table"/></picture></div><div alignment="center" class="sc-kQMZtd gpdZRP"></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO hNqzKI gsk-h-pt-48 gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-d-pt-80 rte-bg-alpha" scrollbarwidth="0" layoutalignment="left" appliedclassnames="gsk-h-pt-48 gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-d-pt-80 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="left" class="sc-cQEGsf cOYBjS"><div width="none" test="true" contentalignment="left" class="sc-fByJgg fDwqeL richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><h3 class="rte-heading-colored">11% of patients discontinued treatment with ZEJULA due to ARs<sup>1</sup></h3> 3912<h3 style="text-align:center;"> </h3> 3913<p><span class="rte-fs-body1 rte-body-colored">ARs resulting in discontinuation of ZEJULA in >1% of patients included thrombocytopenia (3.7%), nausea (1.6%), and anemia (1.2%)<sup>1</sup></span></p> 3914</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div class="sc-gwQtMM wORXp default-class gsk-h-d-pt-32 gsk-h-d-pb-80 gsk-h-pt-8 gsk-h-pb-48" data-component="Footnote" scrollbarwidth="0" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/footnote"><div scrollbarwidth="0" class="sc-jPUqhH jUkzqQ"><div parent="footnote" tagas="Body2" data-component="RTE" class="sc-gVuYvO jsaequ"><p class="rte-body-colored">ARs were managed with dose interruptions and modifications.<br> 3915<sup>a</sup>All ARs consist of grouped preferred terms except for nausea, vomiting, decreased appetite, headache, and insomnia, which are single preferred terms.<br> 3916<sup>b</sup>Common Terminology Criteria for Adverse Events version 4.02.<br> 3917<sup>c</sup>Includes neutropenia, neutropenic infection, neutropenic sepsis, febrile neutropenia.<br> 3918<sup>d</sup>Includes leukopenia, lymphocyte count decreased, lymphopenia, white blood cell count decreased.<br> 3919<sup>e</sup>Includes blood creatinine increased, blood urea increased, acute kidney injury, and renal failure.</p> 3920</div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div id="a2" class="sc-exWHUf lgMziP"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iCobsJ white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h2 class="rte-body-colored">Monitoring and Managing Adverse Reactions</h2> 3921</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Divider" newstylesystemclass="" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/divider" background="noFill" scrollbarwidth="0" linestyle="solid" class="sc-htZDeQ cxRoya gsk-h-pt-20 gsk-h-pb-20 footer-divider"><div background="noFill" scrollbarwidth="0" class="sc-kNdzzL burgKR"><div parent="" linecolor="delta" class="sc-hSEhNS jbWfoB"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO dnwDyl white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3 class="rte-body-colored">Adverse events of ZEJULA may be managed with dose interruption and modification<sup>1,2</sup></h3> 3922<p>In PRIMA, adverse reactions led to dose reduction or interruption in 79% of patients, most frequently (>10%) from thrombocytopenia (53%), anemia (32%), and neutropenia (19%)<sup>1</sup></p> 3923</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iIKcvc white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 white gsk-h-pt-48 gsk-h-pb-16 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="8" test="true" contentalignment="left" class="sc-fByJgg jPiTb richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3 class="rte-heading-colored">Monitoring complete blood counts, blood pressure, and heart rate helps identify the need to dose modify<sup>1</sup></h3> 3924</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Content Card" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="item0,item1" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/content-card" al
3924ignment="center" class="sc-jnGlFn iOvhnB white " scrollbarwidth="0" appliedclassnames="white "><div alignment="center" scrollbarwidth="0" class="sc-gtgTTu kCPxiO"><div imagealignment="center" alignment="center" imageposition="belowTitle" class="sc-yAzml jCTBRV"><div alignment="center" imageposition="belowTitle" class="sc-iTwQZo dKOvfO"></div><div imageposition="belowTitle" imagesize="large" imagealignment="center" alignment="center" class="sc-fvXKBq dcHBsc"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/monitoring-blood-count-and-pressure-mobile.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/monitoring-blood-count-and-pressure.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/monitoring-blood-count-and-pressure.jpg?auto=format" alt="Monitoring requirements infographic" title="Monitoring requirements infographic"/></picture></div><div alignment="center" imageposition="belowTitle" class="sc-iqxcnj imjBtI"><div parent="content group block" tagas="Body1R" data-component="RTE" parenttheme="White" class="sc-gVuYvO bwOOuQ"><p><sup>f</sup>Monitor periodically. Per physician discretion.</p> 3925</div></div><div alignment="center" class="sc-kQMZtd gpdZRP"></div></div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div id="a3" class="sc-exWHUf lgMziP"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO jkyaQe gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><h2 class="rte-body-colored">Individualized Starting Dose</h2> 3926</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Divider" newstylesystemclass="gsk-h-d-pt-20 gsk-h-d-pb-20 gsk-h-pt-20 light gsk-h-pb-20" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/divider" background="fill" scrollbarwidth="0" linestyle="solid" class="sc-htZDeQ czQbe light footer-divider"><div background="fill" scrollbarwidth="0" class="sc-kNdzzL cEYYqA"><div parent="" linecolor="delta" class="sc-hSEhNS jbWfoB"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO hmfLhB gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><h3>An individualized starting dose in IL maintenance, giving your patients a tailored dose from the start<sup>1</sup></h3> 3927</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12 default-class"><div type="fluid" renderingas="data-highlight" scrollbarwidth="0" newstylesystemclass="" class="sc-eYQZus kKvlcQ"><div type="fluid" scrollbarwidth="0" columntype="componentLayout" class="sc-bhdiFL iJbRko"><div headeralignment="top" alignment="none" columntype="componentLayout" class="sc-kWfyEB bqigpW"><div itemcount="2" headeralignment="top" renderingas="data-highlight" maxwidth="Default" columntype="componentLayout" layoutcolumncount="2" iconwithtextlayoutalignment="none" class="sc-gLgbxS kpAkvj"><div headeralignment="top" columntype="componentLayout" rowgap="Default" class="sc-dNNPKj TYDBR"><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-6 c-gd__col-lg-6">
3927<div background="boxed" class="sc-bMNxcX iTazPK card"><div class="sc-jUyjMa bqdWPe card-part"><h3 id="If baseline weight <170 lb OR platelets <150,000/μl" headingas="h3" parent="content group block" parenttheme="light" class="sc-cxYBSk bHiJLY">If baseline weight <170 lb OR platelets <150,000/μl</h3></div><div class="sc-jhrnQV fBsgaj"></div><div class="sc-jUyjMa bqdWPe card-part"><div class="sc-fZGrbc fmhcbI"><div class="sc-edDLmV bYDdQY"><div class="sc-eMMvEe cFZjyl"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">200</p> 3928</div></div><div class="sc-bPujQv jdthnw"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"></div></div></div></div><div class="sc-haVXaE iJBEps"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">mg/day</p> 3929</div></div></div></div></div><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-6 c-gd__col-lg-6"><div background="boxed" class="sc-bMNxcX iTazPK card"><div class="sc-jUyjMa bqdWPe card-part"><h3 id="If baseline weight â¥170 lb AND platelets â¥150,000/μl" headingas="h3" parent="content group block" parenttheme="light" class="sc-cxYBSk bHiJLY">If baseline weight â¥170 lb AND platelets â¥150,000/μl</h3></div><div class="sc-jhrnQV fBsgaj"></div><div class="sc-jUyjMa bqdWPe card-part"><div class="sc-fZGrbc fmhcbI"><div class="sc-edDLmV bYDdQY"><div class="sc-eMMvEe cFZjyl"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">300</p> 3930</div></div><div class="sc-bPujQv jdthnw"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"></div></div></div></div><div class="sc-haVXaE iJBEps"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">mg/day</p> 3931</div></div></div></div></div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO kcvpjG white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pb-16 white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pb-16 white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><p><span class="rte-fs-body1 rte-body-colored">For patients with moderate hepatic impairment,<sup>g</sup> the recommended dosage of ZEJULA is 200 mg once daily, regardless of body weight or platelet count. Monitor patients for hematologic toxicity and reduce the dose, if needed.<sup>1</sup></span></p> 3932<p> </p> 3933<p><span class="rte-body-colored"><sup>g</sup>Total bilirubin â¥1.5 to 3 x ULN and any AST level.<sup>1</sup> As defined by the National Cancer Institute - Organ Dysfunction Working Group (NCI-ODWG) criteria.</span></p> 3934</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div alignment="center" avatarsize="extraLarge" columns="4" avatartype="image" mobileavatarsize="extraLarge" class="sc-hdyPSo kSyNDE"><img src="/content/dam/brs-pharma-us/zejula-hcp/en_US/icons/safety-icon.svg" alt="Safety icon" title="Safety icon" class="sc-iisglc fLuQdM"/><div class="sc-kgvduj copYrU"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><h3 style="text-align:center;">An individualized starting dose was observed to lower rates of select ARs while maintaining efficacy in an exploratory analysis<sup>1,3,4,h</sup></h3> 3935</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO eLyhQh white gsk-h-d-pt-80 gsk-h-d-pb-12 gsk-h-pt-48 gsk-h-pb-12white gsk-h-d-pt-80 gsk-h-d-pb-12 gsk-h-pt-48 gsk-h-pb-12 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-d-pt-80 gsk-h-d-pb-12 gsk-h-pt-48 gsk-h-pb-12white gsk-h-d-pt-80 gsk-h-d-pb-12 gsk-h-pt-48 gsk-h-pb-12 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="6" test="true" contentalignment="center" class="sc-fByJgg brHQzl richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3 class="rte-heading-colored" style="text-align:left;">PRIMA prospectively evaluated the safety and efficacy of an individualized starting dose of either 200 mg or 300 mg, selected based on baseline weight and platelet
3935count<sup>1,2</sup></h3> 3936</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iCobsJ white white rte-bg-alpha" scrollbarwidth="0" layoutalignment="left" appliedclassnames="white white rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="left" class="sc-cQEGsf hQLuNx"><div width="none" test="true" contentalignment="left" class="sc-fByJgg fDwqeL richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3 style="text-align:center;">Rates of select grades 3-4 hematologic ARs in the HRD-positive population<sup>1</sup></h3> 3937</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Content Card" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="item0,item1" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/content-card" alignment="center" class="sc-jnGlFn hrvLcx white gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16" scrollbarwidth="0" appliedclassnames="white gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16"><div alignment="center" scrollbarwidth="0" class="sc-gtgTTu kCPxiO"><div imagealignment="center" alignment="center" imageposition="belowTitle" class="sc-yAzml jCTBRV"><div alignment="center" imageposition="belowTitle" class="sc-iTwQZo dKOvfO"></div><div imageposition="belowTitle" imagesize="large" imagealignment="center" alignment="center" class="sc-fvXKBq dcHBsc"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-hematologic-adverse-reactions-mobile.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-hematologic-adverse-reactions.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-hematologic-adverse-reactions.jpg?auto=format" alt="Bar graph showing hematologic adverse reactions in PRIMA" title="Bar graph showing hematologic adverse reactions in PRIMA"/></picture></div><div alignment="center" class="sc-kQMZtd gpdZRP"></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO khEmFu white gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-pb-16white gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-pb-16white gsk-h-d-pt-80 gsk-h-pt-48 gsk-h-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3>Rates of select grades 1-4 symptomatic gastrointestinal ARs in the HRD-positive population<sup>1</sup></h3> 3938</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Content Card" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="item0,item1" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/content-card" alignment="center" class="sc-jnGlFn iOvhnB white " scrollbarwidth="0" appliedclassnames="white "><div alignment="center" scrollbarwidth="0" class="sc-gtgTTu kCPxiO"><div imagealignment="center" alignment="center" imageposition="belowTitle" class="sc-yAzml jCTBRV"><div alignment="center" imageposition="belowTitle" class="sc-iTwQZo dKOvfO"></div><div imageposition="belowTitle" imagesize="large" imagealignment="center" alignment="center" class="sc-fvXKBq dcHBsc"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/rates-of-adverse-reactions-mobile.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-
3938hcp/en_US/safety/rates-of-adverse-reactions.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/rates-of-adverse-reactions.jpg?auto=format" alt="Gastrointestinal adverse reactions bar graph" title="Gastrointestinal adverse reactions bar graph"/></picture></div><div alignment="center" class="sc-kQMZtd gpdZRP"></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO jkyaQe gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 gsk-h-pt-48 gsk-h-pb-8 gsk-h-d-pt-80 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><h2><span class="rte-heading-colored">The efficacy of ZEJULA was maintained in the HRD-positive and <span class="selection-italic rte-heading-colored">BRCA</span>m population taking an individualized starting dose<sup>1,3,4,h</sup></span></h2> 3939</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12 default-class"><div type="fluid" renderingas="data-highlight" scrollbarwidth="0" newstylesystemclass="" class="sc-eYQZus kKvlcQ"><div type="fluid" scrollbarwidth="0" columntype="componentLayout" class="sc-bhdiFL iJbRko"><div headeralignment="top" alignment="none" columntype="componentLayout" class="sc-kWfyEB bqigpW"><div itemcount="2" headeralignment="top" renderingas="data-highlight" maxwidth="Default" columntype="componentLayout" layoutcolumncount="2" iconwithtextlayoutalignment="none" class="sc-gLgbxS kpAkvj"><div headeralignment="top" columntype="componentLayout" rowgap="Default" class="sc-dNNPKj TYDBR"><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-6 c-gd__col-lg-6"><div background="boxed" class="sc-bMNxcX iTazPK card"><div class="sc-jUyjMa bqdWPe card-part"><h3 id="HRD-positive population " headingas="h3" parent="content group block" parenttheme="light" class="sc-cxYBSk bHiJLY">HRD-positive population </h3></div><div class="sc-jhrnQV fBsgaj"></div><div class="sc-jUyjMa bqdWPe card-part"><div class="sc-fZGrbc fmhcbI"><div class="sc-edDLmV bYDdQY"><div class="sc-eMMvEe cFZjyl"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">61%</p> 3940</div></div><div class="sc-bPujQv jdthnw"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"></div></div></div></div><div class="sc-haVXaE iJBEps"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p><span class="rte-fs-body1 rte-body-colored"><b>reduction in risk of progression or death observed with ZEJULA in HRD-positive population taking an individualized starting dose based on weight and platelet count vs placebo.<sup>1,3</sup></b></span></p> 3941<p style="text-align:center;"><span class="rte-body-colored"><b>HR, 0.39</b></span> (95% CI, 0.22-0.72)</p> 3942</div></div></div></div></div><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-6 c-gd__col-lg-6"><div background="boxed" class="sc-bMNxcX iTazPK card"><div class="sc-jUyjMa bqdWPe card-part"><h3 id="<i>BRCA</i>m population" headingas="h3" parent="content group block" parenttheme="light" class="sc-cxYBSk bHiJLY"><i>BRCA</i>m population</h3></div><div class="sc-jhrnQV fBsgaj"></div><div class="sc-jUyjMa bqdWPe card-part"><div class="sc-fZGrbc fmhcbI"><div class="sc-edDLmV bYDdQY"><div class="sc-eMMvEe cFZjyl"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p class="rte-heading-colored">71%</p> 3943</div></div><div class="sc-bPujQv jdthnw"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"></div></div></div></div><div class="sc-haVXaE iJBEps"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="light" class="sc-gVuYvO hGJZDM"><p><span class="rte-fs-body1 rte-body-colored"><b>reduction in risk of progression or death observed with ZEJULA in <span class="selection-italic rte-body-colored rte-fs-body1"><b>BRCA</b></span>m population taking an individualized starting dose based on weight and platelet
3943count vs placebo.<sup>4</sup></b></span></p> 3944<p style="text-align:center;"><span class="rte-body-colored"><b>HR, 0.29</b></span> (95% CI, 0.13-0.67)</p> 3945</div></div></div></div></div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO jllRoR gsk-h-pt-8 gsk-h-pb-48 gsk-h-d-pb-80 gsk-h-pt-8 gsk-h-pb-48 gsk-h-d-pb-80 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="gsk-h-pt-8 gsk-h-pb-48 gsk-h-d-pb-80 gsk-h-pt-8 gsk-h-pb-48 gsk-h-d-pb-80 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><p class="text-under-data-highlight"><sup>h</sup>Exploratory subgroup analysis, not powered to detect a statistically significant treatment effect. Interpret results with caution.</p> 3946</div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div id="a4" class="sc-exWHUf lgMziP"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO iCobsJ white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 white gsk-h-mt-48 gsk-h-mb-8 gsk-h-d-mt-80 gsk-h-d-mb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h2 class="rte-body-colored">Long-term Safety Data</h2> 3947</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Divider" newstylesystemclass="" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/divider" background="noFill" scrollbarwidth="0" linestyle="solid" class="sc-htZDeQ cxRoya gsk-h-pt-20 gsk-h-pb-20 footer-divider"><div background="noFill" scrollbarwidth="0" class="sc-kNdzzL burgKR"><div parent="" linecolor="delta" class="sc-hSEhNS jbWfoB"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO dnwDyl white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 white gsk-h-pt-8 gsk-h-pb-8 gsk-h-d-pt-16 gsk-h-d-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf quXeZ"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h3>In PRIMA, no new safety signals were reported in the 6.2-year median follow-up<sup>5,6</sup></h3> 3948</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Content Card" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="item0,item1" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/content-card" alignment="center" class="sc-jnGlFn cvqbxn white gsk-h-d-pt-56 gsk-h-pt-32" scrollbarwidth="0" appliedclassnames="white gsk-h-d-pt-56 gsk-h-pt-32"><div alignment="center" scrollbarwidth="0" class="sc-gtgTTu kCPxiO"><div imagealignment="center" alignment="center" imageposition="belowTitle" class="sc-yAzml jCTBRV"><div alignment="center" imageposition="belowTitle" class="sc-iTwQZo dKOvfO"><div parent="content group block" tagas="Body1R" data-component="RTE" parenttheme="White" class="sc-gVuYvO bwOOuQ"><h3 class="rte-heading-colored"><b>
3948TEAE overview from 6.2-year follow-up of the HRD-positive population<sup>6</sup></b></h3></div></div><div imageposition="belowTitle" imagesize="large" imagealignment="center" alignment="center" class="sc-fvXKBq dcHBsc"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/TEAE-Table-mobile.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/TEAE-Table.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/TEAE-Table.jpg?auto=format" alt="TEAE overview table" title="TEAE overview table"/></picture></div><div alignment="center" imageposition="belowTitle" class="sc-iqxcnj imjBtI"><div parent="content group block" tagas="Body1R" data-component="RTE" parenttheme="White" class="sc-gVuYvO bwOOuQ"><p><span class="rte-fs-body1 rte-body-colored">In the PRIMA trial, the most commonly reported TEAEs (grades 1â4) occurring in â¥20% of HRD-positive patients <br> 3949 receiving ZEJULA were thrombocytopenia (67.3%), anemia (66.5%), nausea (62.9%), leukopenia (53.5%), neutropenia (44.1%), constipation (42.4%), fatigue (38.8%), headache (30.6%), abdominal pain (26.1%), insomnia (26.1%), arthralgia (25.7%), vomiting (25.3%), diarrhea (22.9%), hypertension (24.1%), cough (21.6%), and decreased appetite (21.6%).<sup>6</sup></span></p> 3950</div></div><div alignment="center" class="sc-kQMZtd gpdZRP"></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO TbJBl gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24 gsk-h-d-pt-40 gsk-h-d-pb-40 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="light"><h3 class="rte-heading-colored">ARs were consistent with the primary analysis and the known safety profile of ZEJULA<sup>1,6</sup></h3> 3951<h3> </h3> 3952<h3 class="rte-heading-colored">The TEAE-related discontinuation rate was sustained with 6.2-year follow-up<sup>1,6,i</sup></h3> 3953</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO fryasA white gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24white gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24 rte-bg-alpha" scrollbarwidth="0" layoutalignment="center" appliedclassnames="white gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24white gsk-h-d-pt-40 gsk-h-d-pb-40 gsk-h-pt-24 gsk-h-pb-24 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="center" class="sc-cQEGsf iuawbm"><div width="none" test="true" contentalignment="center" class="sc-fByJgg dRDWQD richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><h5 class="rte-heading-colored"><sup>i</sup>At the time of the primary analysis of PRIMA, 11% of patients discontinued treatment with ZEJULA due to ARs<sup>1</sup></h5> 3954<h3> </h3> 3955<p><span class="rte-fs-body1 rte-body-colored">In the primary analysis, ARs resulting in discontinuation of ZEJULA in >1% of patients included thrombocytopenia (3.7%), nausea (1.6%), and anemia (1.2%).<sup>1</sup></span></p> 3956</div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><a data-component="more-links" data-link="true" id="more-links-1,more-links-1" data-link-name="ZEJULA DOSING" aria-label="ZEJULA DOSING" data-link-header="ZEJULA DOSING" href="https://zejulahcp.com/dosing/" target="_self" titlealignment="Left" appliedclassnames="gsk-h-mt-32 gsk-h-pt-4" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/more-links" class="sc-ixhCPY dUiRdn"><h5 headingas="h5" parent="content group block" parenttheme="light" class="sc-kyDMZS hrjYJq">ZEJULA DOSING</h5><i class="sc-kwjbRt fUibXr material-icons" size="24" color="brandBright" weight="100"></i></a></div><div class="aem-GridColumn aem-GridColumn--default--12"><div scrollbarwidth="0" class="sc-VacRR eRozeD white" newstylesystemclass="gsk-h-d-pt-20 gsk-h-d-pb-20 gsk-h-pt-20 gsk-h-pb-20"><div class="sc-jpWuEU kiXhWo MaxWidthContainer"><div id="5starVOC_ZejulaHCP_Safety" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/five-star-voc" data-component="Five Star VOC" class="sc-gPGxza hbUsuK"></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Rich Text Editor" data-component-id="Rich Text Editor" class="sc-fNWSfO bXNcEN white gsk-h-d-pt-40 gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16white gsk-h-d-pt-40 gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16 rte-bg-alpha" scrollbarwidth="0" layoutalignment="left" appliedclassnames="white gsk-h-d-pt-40 gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16white gsk-h-d-pt-40 gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16 rte-bg-alpha" newstylebgclass="rte-bg-alpha"><div layoutalignment="left" class="sc-cQEGsf cOYBjS"><div width="none" test="true" contentalignment="left" class="sc-fByJgg fDwqeL richTextEditorComponent" tagas="Body2" parent="content group block" parenttheme="White"><p>
39561L = first-line; ALT = alanine aminotransferase; AR = adverse reaction; AST = aspartate aminotransferase; <span class="selection-italic">BRCA</span> = breast cancer susceptibility gene; <span class="selection-italic">BRCA</span>m = <span class="selection-italic">BRCA</span>-mutated; CI = confidence interval; HR = hazard ratio; HRD = homologous recombination deficient; TEAE = treatment-emergent adverse event; ULN = upper limit of normal.</p> 3957</div></div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div class="sc-cFKFYw eUalYJ isi-expanded-visible" id="isi-component" scrollbarwidth="0" data-component="isi" data-component-id="ISI + Medwatch" data-collapsed="false" data-expanded="false" aria-label="important safety information" headerheight="0"><article class="sc-ctvTiz fUcfro"><div aria-label="ISI+Medwatch" class="sc-dZYIEs cjkhYu"><div aria-label="INDICATION & IMPORTANT SAFETY INFORMATION" data-link="true" data-link-name="peek-a-boo=expand" class="sc-dMvfzH hDxTwv"><h3 headingas="h3" parent="content group block" parenttheme="White" class="sc-cxYBSk bHiJLY">INDICATION & IMPORTANT SAFETY INFORMATION</h3></div><div data-link-name="peek-a-boo=expand" scrollbarwidth="0" data-link="true" class="sc-fXtVOD kQQgFb"><div scrollbarwidth="0" class="sc-kujvwK fkoJgN"><div class="sc-jyqPPl hpltwr leftTitle"><h3 headingas="h3" parent="content group block" parenttheme="White" class="sc-cxYBSk bHiJLY ISIDesktopTitle">INDICATION</h3></div><div class="sc-jyqPPl hpltwr rightTitle"><span><h3 headingas="h3" parent="content group block" parenttheme="White" class="sc-cxYBSk bHiJLY ISIDesktopTitle">IMPORTANT SAFETY INFORMATION</h3></span></div></div></div><div class="sc-fUsNjh doeMrf"><article class="sc-cwutml jtnLaV"><div class="sc-bUzBjj eLBbNm"><div group="groupA" class="sc-imjflA kMQNdZ"><div group="groupA" scrollbarwidth="0" class="sc-fwEu kJSuJM"><div class="sc-dPtFDt hVebib"><h3 headingas="h3" parent="content group block" parenttheme="White" class="sc-cxYBSk bHiJLY">INDICATION</h3></div></div></div></div><div group="groupA" class="sc-imjflA kMQNdZ content-container"><div class="sc-hrOxDu dxYeQy"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="White" class="sc-gVuYvO hGJZDM"><p class="rte-fs-body1">ZEJULA is indicated for first-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy and whose cancer is associated with homologous recombination deficiency (HRD) - positive status defined by either a deleterious or suspected deleterious <span class="selection-italic rte-fs-body1">BRCA</span> mutation, and/or genomic instability. Select patients for therapy based on an FDA-authorized companion diagnostic for ZEJULA.</p> 3958</div></div></div></article><article class="sc-cwutml jtnLaV"><div class="sc-bUzBjj eLBbNm"><div group="groupB" class="sc-imjflA hhSRpd"><div group="groupB" scrollbarwidth="0" class="sc-fwEu kJSuJM"><div class="sc-dPtFDt hVebib"><h3 headingas="h3" parent="content group block" parenttheme="White" class="sc-cxYBSk bHiJLY">IMPORTANT SAFETY INFORMATION</h3></div></div></div></div><div group="groupB" class="sc-imjflA hhSRpd content-container"><div class="sc-hrOxDu dxYeQy"><div parent="content group block" tagas="Body2" data-component="RTE" parenttheme="White" class="sc-gVuYvO hGJZDM"><p><span class="selection-bold">Myelodysplastic syndrome/acute myeloid leukemia</span> (MDS/AML), including cases with a fatal outcome, have been reported in patients who received ZEJULA. In PRIMA, of patients within the HRD-positive population, MDS/AML occurred in 8 out of 245 (3.3%) patients treated with ZEJULA, and in 3 out of 125 (2.4%) patients treated with placebo with a follow-up of 6.1 years. The duration of therapy with ZEJULA in patients who developed secondary MDS/cancer therapy-related AML varied from 5.5 months to 5 years. All patients who developed secondary MDS/cancer therapy-related AML had received previous chemotherapy with platinum agents and/or other DNA-damaging agents, including radiotherapy. For suspected MDS/AML or prolonged hematological toxicities, refer the patient to a hematologist for further evaluation. Discontinue ZEJULA if MDS/AML is confirmed.</p> 3959<p> </p> 3960<p><span class="selection-bold">Hematologic adverse reactions</span> (thrombocytopenia, anemia, neutropenia, and/or pancytopenia) have been reported in patients receiving ZEJULA. The overall incidence of Grade â¥3 thrombocytopenia, anemia, and neutropenia were reported, respectively, in 39%, 31%, and 21% of patients receiving ZEJULA in PRIMA. Discontinuation due to thrombocytopenia, anemia, and neutropenia occurred, respectively, in 4%, 2%, and 2% of patients in PRIMA. In patients who were administered a starting dose of ZEJULA based on baseline weight or platelet
3960count in PRIMA, Grade â¥3 thrombocytopenia, anemia, and neutropenia were reported, respectively, in 22%, 23%, and 15% of patients receiving ZEJULA. Discontinuation due to thrombocytopenia, anemia, and neutropenia occurred, respectively, in 3%, 3%, and 2% of patients. Do not start ZEJULA until patients have recovered from hematological toxicity caused by prior chemotherapy (â¤Grade 1). Monitor complete blood counts weekly for the first month, monthly for the next 11 months, and periodically thereafter. If hematological toxicities do not resolve within 28 days following interruption, discontinue ZEJULA, and refer the patient to a hematologist for further investigations.</p> 3961<p> </p> 3962<p><span class="selection-bold">Hypertension and cardiovascular effects</span> have been reported in patients receiving ZEJULA. Grade 3-4 hypertension occurred in 6% of patients receiving ZEJULA vs 1% of patients receiving placebo in PRIMA, with no reported discontinuations. Monitor blood pressure and heart rate at least weekly for the first two months, then monthly for the first year, and periodically thereafter during treatment with ZEJULA. Closely monitor patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. Manage hypertension with antihypertensive medications and adjustment of the ZEJULA dose if necessary.</p> 3963<p> </p> 3964<p><span class="selection-bold">Posterior reversible encephalopathy syndrome (PRES)</span> occurred in 0.1% of 2,165 patients treated with ZEJULA in clinical trials and has also been described in postmarketing reports. Monitor all patients for signs and symptoms of PRES, which include seizure, headache, altered mental status, visual disturbance, or cortical blindness, with or without associated hypertension. Diagnosis requires confirmation by brain imaging. If suspected, promptly discontinue ZEJULA and administer appropriate treatment. The safety of reinitiating ZEJULA is unknown.<
3964/p> 3965<p> </p> 3966<p><span class="selection-bold">Embryo-fetal toxicity and lactation:</span> Based on its mechanism of action, ZEJULA can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception during treatment and for 6 months after receiving their final dose of ZEJULA. Because of the potential for serious adverse reactions from ZEJULA in breastfed infants, advise lactating women not to breastfeed during treatment with ZEJULA and for 1 month after receiving the last dose.</p> 3967<p> </p> 3968<p><span class="selection-bold">First-line Maintenance Treatment of HRD-Positive Advanced Ovarian Cancer</span></p> 3969<p>Most common adverse reactions (Grades 1-4) in â¥10% of all patients who received ZEJULA in PRIMA were thrombocytopenia (66%), anemia (65%), nausea (62%), fatigue (52%), musculoskeletal pain (46%), neutropenia (43%), constipation (40%), leukopenia (29%), headache (27%), insomnia (25%), vomiting (23%), dyspnea (21%), decreased appetite (20%), dizziness (20%), cough (20%), hypertension (20%), AST/ALT elevation (14%), acute kidney injury (13%), and anxiety (12%).</p> 3970<p> </p> 3971<p>Common lab abnormalities (Grades 1-4) in â¥25% of all patients who received ZEJULA in PRIMA included: decreased hemoglobin (85%), decreased leukocytes (72%), decreased platelets (71%), decreased neutrophils (64%), increased glucose (62%), decreased lymphocytes (55%), increased alkaline phosphatase (48%), increased creatinine (40%), decreased magnesium (39%), increased AST (35%), increased ALT (32%), and increased calcium (31%).</p> 3972<p> </p> 3973<p><span class="selection-bold">Please see the full <a href="https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Zejula_Tablets/pdf/ZEJULA-TABLETS-PI-PIL.PDF">Prescribing Information</a> for ZEJULA.</span></p> 3974</div></div></div></article></div></div></article></div><div data-component="medwatch" scrollbarwidth="0" class="sc-gwqnNT fFTfgA"><div align="center" class="sc-kTfNwa fNcYbh"><h5 headingas="h5" parent="content group block" class="sc-kyDMZS hrjYJq">To report SUSPECTED ADVERSE REACTIONS, contact GSK at <a href="https://gsk.public.reportum.com" data-link="true" data-link-name="gsk.public.reportum.com">gsk.public.reportum.com</a> or <a href="tel:18888255249" data-link="true" data-link-name="1-888-825-5249">1-888-825-5249</a> or <br class="desktop-only"> FDA at <a href="tel:18003321088" data-link="true" data-link-name="1-800-FDA-1088">1-800-FDA-1088</a> or <a href="https://www.fda.gov/medwatch" data-link="true" data-link-name="www.fda.gov/medwatch">www.fda.gov/medwatch</a>.</h5></div></div><button tabindex="0" style="right:0;bottom:5vh" type="button" role="button" aria-hidden="true" aria-label="scroll to top" icon-Label="caret" class="sc-eGHeJU dHONEW isi-expanded-visible" data-component="back to top" data-visible="false" data-link="true" data-link-name="back to top"><i class="sc-kwjbRt ijlRLD material-icons material-symbols-rounded" size="20" color="brandBright" weight="100"></i></button></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div data-link-header="References" data-component="References" data-component-id="References" class="sc-bnRfdH eyKYiy default-class "><h2 headingas="h2" parent="content group block" class="sc-jlVhvo bYBfRt sc-jvBRMK ecyeIf">References</h2><div class="sc-hOsbzN gEittx"><div parent="content group block" tagas="Body1R" class="sc-gVuYvO bwOOuQ referncesRTE" data-component="RTE"><ol class="rte-fs-body1"> 3975<li><span class="selection-bold"></span>ZEJULA (niraparib). Prescribing Information. GSK; 2026.</li> 3976<li>González-MartÃn A et al. <span class="selection-italic">N Engl J Med</span>. 2019;381(25):2391-2402. doi:NEJMoa1910962</li> 3977<li>Mirza MR et al. <span class="selection-italic">
3977Cancer.</span> 2023;1-110. doi:10.1002/cncr.34706</li> 3978<li>Korach J et al.<span class="selection-italic"> Int J Gynecol Cancer</span>. 2020;30(suppl 4):A125-A126. doi:10.1136/ijgc-2020-ESGO.220</li> 3979<li>Monk BJ et al. <span class="selection-italic">Ann Oncol</span>. 2024;35(11):981-992. doi:10.1016/j.annonc.2024.08.2241</li> 3980<li>Data on file, GSK.</li> 3981</ol> 3982</div></div></div></div></div></div><div class="aem-GridColumn aem-GridColumn--default--12"><div class=" aem-container"><nav class="sc-gynQXr lnaWDa fab-icon isi-expanded-visible default-class" data-component="fab" componentResponse="[object Object]" cqItems="[object Object]" cqItemsOrder="" cqType="authorableComponents/core/components/brs-pharma-us/component-definitions/fab" style="right:0;bottom:5vh"><div class="sc-etVtso fwWArq"><span class="wizard-chatbot inbenta-chatbot"><span class="chatbot-container"><a isexpandstatus="true" target="_self" tabindex="0" role="button" data-link="true" data-link-name="chat" data-cta="chat" aria-label="chat" isfabmenutitleexist="false" class="sc-freCKs bLNbGW"><div label="" class="sc-ctMqWJ efdrFU"><i class="sc-kwjbRt ijlRLD material-icons material-symbols-rounded" size="20" color="brandBright" weight="100"></i></div></a></span></span></div></nav><div class="gsk-patient-grid"><div type="fluid" renderingas="container" scrollbarwidth="0" newstylesystemclass="" class="sc-eYQZus cMSuFS"><div type="fluid" scrollbarwidth="0" columntype="variable" class="sc-bhdiFL iJbRko"><div headeralignment="top" alignment="none" columntype="variable" class="sc-kWfyEB fuYckO"><div itemcount="2" headeralignment="top" renderingas="container" maxwidth="Default" columntype="variable" layoutcolumncount="4" iconwithtextlayoutalignment="none" class="sc-gLgbxS fwJCxv"><div headeralignment="top" columntype="variable" rowgap="None" class="sc-dNNPKj gRQIOL"><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-12 c-gd__col-lg-6"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"><div class="aem-GridColumn aem-GridColumn--default--12"><div data-component="Patient Support Card" data-component-id="main content" newstylesystemclass="" class="sc-lbzlIR ptNob default-class isi-expanded-visible" componentresponse="[object Object]" cqitems="[object Object]" cqitemsorder="" cqtype="authorableComponents/core/components/brs-pharma-us/component-definitions/patient-support-card"><a href="https://www.togetherwithgsk.com/zejula/hcp/" target="_self" aria-label="Together with ZEJULA" data-link-name="together with zejula" data-link-description="" data-link="true" data-component="Logo" class="sc-bAPsAg iesoIi"><picture><source media="(max-width:767.5px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/together-with-zejula-logo.jpg?auto=format"/><source media="(min-width:768px)" srcSet="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/together-with-zejula-logo.jpg?auto=format"/><img src="https://i-cf65.gskstatic.com/content/dam/brs-pharma-us/zejula-hcp/en_US/together-with-zejula-logo.jpg?auto=format" alt="Together with ZEJULA (niraparib) logo." title="Together with ZEJULA (niraparib) logo."/></picture></a><div class="sc-jSVqRe kdbgFv"><div parent="content group block" tagas="Body2" data-component="RTE" class="sc-gVuYvO hGJZDM"><p class="rte-fs-body1">If your patients need help paying for their medicines or want to learn about other patient access and reimbursement services, please visit this <a class="rte-fs-body1" href="https://www.togetherwithgsk.com/zejula/hcp/" data-link="true" data-link-name="website" data-link-exit="true" data-link-download="false">website</a> or call <span class="rte-text-nowrap"><a class="rte-fs-body1" href="tel:18444475662" data-link="true" data-link-name="1-844-4GSK-ONC" data-link-exit="false" data-link-download="false">1-844-4GSK-ONC</a></span> <span class="rte-text-nowrap">(<a class="rte-fs-body1" href="tel:18444475662" data-link="true" data-link-name="1-844-447-5662" data-link-exit="false" data-link-download="false">1-844-447-5662</a>)</span>.</p> 3983</div></div></div></div></div></div><div class="sc-gyHSyk dpAXJK c-gd__col-12 c-gd__col-sm-12 c-gd__col-lg-6"><div class=" aem-Grid aem-Grid--12 aem-Grid--default--12 aem-container"></div></div></div></div></div></div></div></div><footer data-page-section="footer" data-component-id="footer" scrollbarWidth="0" id="footer-component" class="sc-jSDDAQ iYbTRM footer-visible isi-expanded-visible white "><div data-component="footer" scrollbarwidth="0" class="sc-kqtCJ hKKDgI footer"><div class="sc-cjWkmD eOsfGi"><ul class="sc-cIAOVF dOfvxj"><li><div rendertype="link" iconposition="left" icon="" text="Legal Notice" buttonoptions="[object Object]" linkoptions="[object Object]" textalignment="left" class="sc-dqLwBE hdnSiw ButtonContainerWrapper">
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Monitor patients for hematologic toxicity and reduce the dose, if needed.<sup>1</sup></span></p>\r\n<p> </p>\r\n<p><span class=\"rte-body-colored\"><sup>g</sup>Total bilirubin â¥1.5 to 3 x ULN and any AST level.<sup>1</sup> As defined by the National Cancer Institute - Organ Dysfunction Working Group (NCI-ODWG) criteria.</span></p>\r\n","contentAlignment":"center","enableSafePadding":"false","width":"none","isAuthorable":true,"layoutAlignment":"center","textIsRich":"true","appliedCssClassNames":"white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pb-16","analytics":{}},"success":true},":items":{},":itemsOrder":[],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/rte"},"icons_with_text":{"componentResponse":{"data":{"description":"<h3 style=\"text-align: center;\">An individualized starting dose was observed to lower rates of select ARs while maintaining efficacy in an exploratory analysis<sup>1,3,4,h</sup></h3>\r\n","materialIconStyle":"filled","imageLabel":"Safety icon","imageTitle":"Safety icon","avatarType":"image","image":"/content/dam/brs-pharma-us/zejula-hcp/en_US/icons/safety-icon.svg","isAuthorable":true,"textIsRich":"true","appliedCssClassNames":"white gsk-h-mt-64 gsk-h-mb-64"},"success":true},":items":{},":itemsOrder":[],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/icons-with-text"},"rte_107638104":{"componentResponse":{"data":{"fullWidth":"false","richText":"<h3 class=\"rte-heading-colored\" style=\"text-align: left;\">PRIMA prospectively evaluated the safety and efficacy of an individualized starting dose of either 200 mg or 300 mg, selected based on baseline weight and platelet count<sup>1,2</sup></h3>\r\n","contentAlignment":"center","enableSafePadding":"false","width":"6","isAuthorable":true,"layoutAlignment":"center","textIsRich":"true","appliedCssClassNames":"white gsk-h-pt-48 gsk-h-pb-12 gsk-h-d-pt-80 gsk-h-d-pb-12","analytics":{},"customAppliedCssClassNames":"gsk-h-d-pt-80 gsk-h-d-pb-12 gsk-h-pt-48 gsk-h-pb-12"},"success":true},":items":{},":itemsOrder":[],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/rte"},"rte_1969082475":{"componentResponse":{"data":{"fullWidth":"false","richText":"<h3 style=\"text-align: center;\">Rates of select grades 3-4 hematologic ARs in the HRD-positive population<sup>1</sup></h3>\r\n","contentAlignment":"left","enableSafePadding":"false","width":"none","isAuthorable":true,"layoutAlignment":"left","textIsRich":"true","appliedCssClassNames":"white","analytics":{}},"success":true},":items":{},":itemsOrder":[],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/rte"},"content_card":{"componentResponse":{"data":{"imageLabel":"Bar graph showing hematologic adverse reactions in PRIMA","imageTitle":"Bar graph showing hematologic adverse reactions in PRIMA","mobileImage":"/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-hematologic-adverse-reactions-mobile.jpg","titleAs":"h2","imageSize":"large","image":"/content/dam/brs-pharma-us/zejula-hcp/en_US/safety/prima-hematologic-adverse-reactions.jpg","isAuthorable":true,"imageAlignment":"center","textIsRich":["true","true"],"alignment":"center","imagePosition":"belowTitle","appliedCssClassNames":"white","analytics":{},"customAppliedCssClassNames":"gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16","accessibility":{}},"success":true},":items":{"item0":{"componentResponse":{"errorMessage":"No data available to export. 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3988 ULN = upper limit of normal.</p>\r\n","contentAlignment":"left","enableSafePadding":"false","width":"none","isAuthorable":true,"layoutAlignment":"left","textIsRich":"true","appliedCssClassNames":"white gsk-h-pt-16 gsk-h-pb-16 gsk-h-d-pt-40 gsk-h-d-pb-80","analytics":{},"customAppliedCssClassNames":"gsk-h-d-pt-40 gsk-h-d-pb-80 gsk-h-pt-16 gsk-h-pb-16"},"success":true},":items":{},":itemsOrder":[],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/rte"}},":itemsOrder":["rte_copy_copy_copy","divider_copy_copy_co","rte_copy","content_card","rte_1772518611_copy","rte_1772518611_copy_","more_links","five_star_voc_802907927","rte_434552855"],":type":"boreas/components/container"}},":itemsOrder":["item0"],":type":"authorableComponents/core/components/brs-pharma-us/component-definitions/sticky-anchor-container"},"experiencefragment_c":{"id":"experiencefragment-2994c61dfe","localizedFragmentVariationPath":"/content/experience-fragments/brs-pharma-us/zejula-hcp/en_US/isi/master/jcr:content","configured":true,"classNames":"aem-xf",":items":{"root":{"columnCount":12,"columnClassNames":{"isi":"aem-GridColumn aem-GridColumn--default--12"},"gridClassNames":"aem-Grid aem-Grid--12 aem-Grid--default--12",":items":{"isi":{"componentResponse":{"data":{"isMedwatch":"true","titleAs":"h3","medwatchAlign":"center","rightWarning":false,"titleA":"INDICATION","titleB":"IMPORTANT SAFETY INFORMATION","titleC":"INDICATION & IMPORTANT SAFETY INFORMATION","contentA":"<p class=\"rte-fs-body1\">ZEJULA is indicated for first-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy and whose cancer is associated with homologous recombination deficiency (HRD) - positive status defined by either a deleterious or suspected deleterious <span class=\"selection-italic rte-fs-body1\">BRCA</span> mutation, and/or genomic instability. Select patients for therapy based on an FDA-authorized companion diagnostic for ZEJULA.</p>\r\n","contentB":"<p><span class=\"selection-bold\">Myelodysplastic syndrome/acute myeloid leukemia</span> (MDS/AML), including cases with a fatal outcome, have been reported in patients who received ZEJULA. In PRIMA, of patients within the HRD-positive population, MDS/AML occurred in 8 out of 245 (3.3%) patients treated with ZEJULA, and in 3 out of 125 (2.4%) patients treated with placebo with a follow-up of 6.1 years. The duration of therapy with ZEJULA in patients who developed secondary MDS/cancer therapy-related AML varied from 5.5 months to 5 years. All patients who developed secondary MDS/cancer therapy-related AML had received previous chemotherapy with platinum agents and/or other DNA-damaging agents, including radiotherapy. For suspected MDS/AML or prolonged hematological toxicities, refer the patient to a hematologist for further evaluation. Discontinue ZEJULA if MDS/AML is confirmed.</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">Hematologic adverse reactions</span> (thrombocytopenia, anemia, neutropenia, and/or pancytopenia) have been reported in patients receiving ZEJULA. The overall incidence of Grade â¥3 thrombocytopenia, anemia, and neutropenia were reported, respectively, in 39%, 31%, and 21% of patients receiving ZEJULA in PRIMA. Discontinuation due to thrombocytopenia, anemia, and neutropenia occurred, respectively, in 4%, 2%, and 2% of patients in PRIMA. In patients who were administered a starting dose of ZEJULA based on baseline weight or platelet count in PRIMA, Grade â¥3 thrombocytopenia, anemia, and neutropenia were reported, respectively, in 22%, 23%, and 15% of patients receiving ZEJULA. Discontinuation due to thrombocytopenia, anemia, and neutropenia occurred, respectively, in 3%, 3%, and 2% of patients. Do not start ZEJULA until patients have recovered from hematological toxicity caused by prior chemotherapy (â¤Grade 1). Monitor complete blood counts weekly for the first month, monthly for the next 11 months, and periodically thereafter. If hematological toxicities do not resolve within 28 days following interruption, discontinue ZEJULA, and refer the patient to a hematologist for further investigations.</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">Hypertension and cardiovascular effects</span> have been reported in patients receiving ZEJULA. Grade 3-4 hypertension occurred in 6% of patients receiving ZEJULA vs 1% of patients receiving placebo in PRIMA, with no reported discontinuations. Monitor blood pressure and heart rate at least weekly for the first two months, then monthly for the first year, and periodically thereafter during treatment with ZEJULA. Closely monitor patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. Manage hypertension with antihypertensive medications and adjustment of the ZEJULA dose if necessary.</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">Posterior reversible encephalopathy syndrome (PRES)</span> occurred in 0.1% of 2,165 patients treated with ZEJULA in clinical trials and has also been described
3988in postmarketing reports. Monitor all patients for signs and symptoms of PRES, which include seizure, headache, altered mental status, visual disturbance, or cortical blindness, with or without associated hypertension. Diagnosis requires confirmation by brain imaging. If suspected, promptly discontinue ZEJULA and administer appropriate treatment. The safety of reinitiating ZEJULA is unknown.</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">Embryo-fetal toxicity and lactation:</span> Based on its mechanism of action, ZEJULA can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception during treatment and for 6 months after receiving their final dose of ZEJULA. Because of the potential for serious adverse reactions from ZEJULA in breastfed infants, advise lactating women not to breastfeed during treatment with ZEJULA and for 1 month after receiving the last dose.</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">First-line Maintenance Treatment of HRD-Positive Advanced Ovarian Cancer</span></p>\r\n<p>Most common adverse reactions (Grades 1-4) in â¥10% of all patients who received ZEJULA in PRIMA were thrombocytopenia (66%), anemia (65%), nausea (62%), fatigue (52%), musculoskeletal pain (46%), neutropenia (43%), constipation (40%), leukopenia (29%), headache (27%), insomnia (25%), vomiting (23%), dyspnea (21%), decreased appetite (20%), dizziness (20%), cough (20%), hypertension (20%), AST/ALT elevation (14%), acute kidney injury (13%), and anxiety (12%).</p>\r\n<p> </p>\r\n<p>Common lab abnormalities (Grades 1-4) in â¥25% of all patients who received ZEJULA in PRIMA included: decreased hemoglobin (85%), decreased leukocytes (72%), decreased platelets (71%), decreased neutrophils (64%), increased glucose (62%), decreased lymphocytes (55%), increased alkaline phosphatase (48%), increased creatinine (40%), decreased magnesium (39%), increased AST (35%), increased ALT (32%), and increased calcium (31%).</p>\r\n<p> </p>\r\n<p><span class=\"selection-bold\">Please see the full <a href=\"https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Zejula_Tablets/pdf/ZEJULA-TABLETS-PI-PIL.PDF\">Prescribing Information</a> for ZEJULA.</span></p>\r\n","cacheType":"none","combinedWarning":false,"leftWarning":false,"font":"Body-2","href":"https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Zejula_Tablets/pdf/ZEJULA-TABLETS-PI-PIL.PDF#nameddest=PIL","snippetA":"<p class=\"rte-fs-body1\">ZEJULA is indicated for first-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy and whose cancer is associated with homologous recombination deficiency (HRD) - positive status defined by either a deleterious or suspected deleterious <span class=\"selection-italic rte-fs-body1\">BRCA</span> mutation, and/or genomic instability. Select patients for therapy based on an FDA-authorized companion diagnostic for ZEJULA.</p>\r\n","snippetB":"<p><span class=\"selection-bold\">Myelodysplastic syndrome/acute myeloid leukemia</span> (MDS/AML), including cases with a fatal outcome, have been reported in patients who received ZEJULA. In PRIMA, of patients within the HRD-positive population, MDS/AML occurred in 8 out of 245 (3.3%) patients treated with ZEJULA, and in 3 out of 125 (2.4%) patients treated with placebo with a follow-up of 6.1 years. The duration of therapy with ZEJULA in patients who developed secondary MDS/cancer therapy-related AML varied from 5.5 months to 5 years. All patients who developed secondary MDS/cancer therapy-related AML had received previous chemotherapy with platinum agents and/or other DNA-damaging agents, including radiotherapy. For suspected MDS/AML or prolonged hematological toxicities, refer the patient to a hematologist for further evaluation. 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