https://acaai.org/wp-content/plugins/pcipr-images-hotspots/js/pcipr-image-hotspots.js?ver=1790164902

1jQuery(document).ready(function(){
2
3    if(jQuery("#inflammation_connection").length){
4        jQuery("#inflammation_connection").hotspot({
5            mode: 'display',
6            data: [
7                {"x":52.4,"y":12.75,"Title":"Allergic rhinitis","Message":"<div class='one-column'><ul><li>Nasal symptoms, including congestion, rhinorrhea or postnasal drip, repetitive sneezing</li><li>Nasal, throat, eye itching</li><li>Red, puffy watery eyes</li></ul></div>"},
8                {"x":60.75,"y":16.1,"Title":"CRSwNP","Message":"<div class='one-column'><ul><li>Nasal symptoms, including congestion, rhinorrhea or postnasal drip, repetitive sneezing</li><li>Decreased or loss of sense of smell</li><li>Snoring</li></ul></div>"},
9                {"x":49.1,"y":40.8,"Title":"EoE","Message":"<span>Symptoms vary by age:</span><div class='two-column'><div class='left-column'>Infants and children:<br><ul><li>Feeding difficulties</li><li>Failure to thrive</li><li>Irritability</li><li>Regurgitation/emesis</li></ul></div><div class='right-column'>Adolescents and adults:<br><ul><li>Dysphagia</li><li>Esophageal food bolus impaction</li><li>Chest pain</li></ul></div></div>"},
10                {"x":40.4,"y":54.3,"Title":"Asthma","Message":"<div class='one-column'><ul><li>Frequent coughing and/or wheezing, especially nocturnal or exercise-induced</li><li>Dyspnea</li><li>Chest tightness</li></ul></div>"},
11                {"x":45.35,"y":82.8,"Title":"Food allergies","Message":"<div class='two-column'><div class='left-column'>Common<ul><li>Urticaria</li><li>Angioedema</li><li>Nausea, emesis, diarrhea</li><li>Rhinorrhea</li><li>Dyspnea</li><li>Bronchospasm</li><li>Dizziness</li></ul></div><div class='right-column'>Severe (Anaphylaxis)<ul><li>Tachycardia</li><li>Hypotension</li><li>Shock</li><li>Loss of consciousness</li></ul></div></div>"},
12                {"x":77.44,"y":87.9,"Title":"Atopic dermatitis","Message":"<div class='one-column'><ul><li>Erythema or erythematous maculopapular rash</li><li>Severe pruritis</li><li>Dry skin, which can crack and bleed</li></ul></div>"},
13            ],
14            interactivity: "hover",
15        });
16
17        jQuery("#inflammation_connection_mobile_view").hotspot({
18            mode: 'display',
19            data: [
20                {"x":52.4,"y":12.75,"Title":"Allergic rhinitis","Message":"<div class='one-column'><ul><li>Nasal symptoms, including congestion, rhinorrhea or postnasal drip, repetitive sneezing</li><li>Nasal, throat, eye itching</li><li>Red, puffy watery eyes</li></ul></div>"},
21                {"x":60.75,"y":16.1,"Title":"CRSwNP","Message":"<div class='one-column'><ul><li>Nasal symptoms, including congestion, rhinorrhea or postnasal drip, repetitive sneezing</li><li>Decreased or loss of sense of smell</li><li>Snoring</li></ul></div>"},
22                {"x":49.1,"y":40.8,"Title":"EoE","Message":"<span>Symptoms vary by age:</span><div class='two-column'><div class='left-column'>Infants and children:<br><ul><li>Feeding difficulties</li><li>Failure to thrive</li><li>Irritability</li><li>Regurgitation/emesis</li></ul></div><div class='right-column'>Adolescents and adults:<br><ul><li>Dysphagia</li><li>Esophageal food bolus impaction</li><li>Chest pain</li></ul></div></div>"},
23                {"x":40.4,"y":54.3,"Title":"Asthma","Message":"<div class='one-column'><ul><li>Frequent coughing and/or wheezing, especially nocturnal or exercise-induced</li><li>Dyspnea</li><li>Chest tightness</li></ul></div>"},
24                {"x":45.35,"y":82.8,"Title":"Food allergies","Message":"<div class='two-column'><div class='left-column'>Common<ul><li>Urticaria</li><li>Angioedema</li><li>Nausea, emesis, diarrhea</li><li>Rhinorrhea</li><li>Dyspnea</li><li>Bronchospasm</li><li>Dizziness</li></ul></div><div class='right-column'>Severe (Anaphylaxis)<ul><li>Tachycardia</li><li>Hypotension</li><li>Shock</li><li>Loss of consciousness</li></ul></div></div>"},
25                {"x":77.44,"y":87.9,"Title":"Atopic dermatitis","Message":"<div class='one-column'><ul><li>Erythema or erythematous maculopapular rash</li><li>Severe pruritis</li><li>Dry skin, which can crack and bleed</li></ul></div>"},
26            ],
27            interactivity: "click",
28        });
29
30        jQuery("#inflammation_casscade").hotspot({
31            mode: 'display',
32            data: [
33                {"x":48.42,"y":3.1,"Title":"Environment","Message":"Environmental triggers such as allergens (pollen, animal dander, dust mites), pollutants (smoke, ozone), weather changes, viruses and bacteria can interact with the epithelial layer, the physical barrier covering the skin, nose, lungs, sinuses and esophagus. The immune system responds to these insults with a variety of inflammatory responses."},
34                {"x":70.35,"y":15.52,"Title":"Epithelium","Message":"The epithelium plays a key role in tissue homeostasis and serves as a structural and functional barrier between the environment and immune system. Changes to the epithelium over time can worsen these conditions or cause permanent damage."},
35                {"x":47.45,"y":25.7,"Title":"Alarmins","Message":"In response to triggers, the epithelium releases alarmins, such as TSLP, IL-25 and IL-33, which in turn activate downstream inflammatory responses. Epithelial alarmins initiate a cascade of processes, including:<ul><li>Activating downstream immune responses.</li><li>Activating type 2 inflammatory (Th2) cells which leads to adaptive immunity, the body's acquired or specific defense system involving antibody production.</li><li>Activating ILC2s (innate lymphoid cells) which leads to upregulation of innate immunity. This is the body's first line of defense and is non-specific, meaning it reacts generally to any foreign substance that enters the body.</li></ul>"},
36                {"x":58.1,"y":41.4,"Title":"Allergic pathway","Message":"In the allergic pathway, the alarmins activate Th2 cells to produce IL-4, IL-5 and IL-13. Il-4 and IL-13 – which are involved in B-cell production – activate production of IgE."},
37                {"x":21.9,"y":46.63,"Title":"IgE","Message":"IgE attaches to mast cells when exp

37osed to allergens, causing the mast cells to release several mediators, including histamines and leukotrienes."},
38                {"x":80.68,"y":47,"Title":"IL-13 Cells","Message":"IL-13 – which is produced by both Th2 cells and IL-C2 cells – is involved in driving mucous production, smooth muscle hyperreactivity and contraction, and the production of nitric oxide at the epithelial layer."},
39                {"x":48.77,"y":55.42,"Title":"IL-4 Cells","Message":"IL-4 is important for differentiation of T null cells to Th2 cells, the major lymphocyte involved in type 2 inflammation. Also, IL-4, with some effect by IL-13, is key for B cell isotype switching for IgE production. In addition, it plays a role for chemotaxis of eosinophils to the target organ."},
40                {"x":68.95,"y":54.7,"Title":"IL-5 Cells","Message":"In the eosinophilic pathway, IL-5 is produced by Th2 cells and IL-C2 cells. IL-5 is involved in the production of eosinophils from stem cells in bone marrow and surviving eosinophils in circulation. IL-4, IL-5 and IL-13 attract eosinophils to the targeted organ. When eosinophils are simulated, they produce a variety of mediators, including eosinophilic cationic protein and major basic protein, all of which result in eosinophilic inflammation."},
41            ],
42            interactivity: "hover"
43        });
44
45        setTimeout(function(){
46            jQuery("#inflammation_connection_mobile_view").find(".HotspotPlugin_Hotspot").each(function(k, v){
47               jQuery(this).addClass("inflammation_connection_mobile_hotspot_" + k);
48            });
49
50            jQuery("#inflammation_connection_mobile_view").on("click", ".HotspotPlugin_Hotspot", function(){
51                var hotspot_class = jQuery(this).attr("class").split(" ").filter(function(v){
52                    return v.indexOf("inflammation_connection_mobile_hotspot_") > -1;
53                })[0];
54                jQuery("#inflammation_connection_mobile_view").find("." + hotspot_class + ' > div').hide();
55                jQuery("#inflammation_connection_mobile_view_hotspots > div").removeClass("show");
56                jQuery("#inflammation_connection_mobile_view_hotspots").find("." + hotspot_class).toggleClass("show");
57            });
58        }, 2000);
59    }
60    show_acaai_content( 1 );
61
62    jQuery( '.acaai-btn-1' ).on('click', function(){
63        show_acaai_content( 1 );
64    }).hover(
65    function() {
66        show_acaai_content( 1 );
67    })
68
69    jQuery( '.acaai-btn-2' ).on('click', function(){
70        show_acaai_content( 2 );
71    }).hover(
72    function() {
73        show_acaai_content( 2 );
74    })
75
76    jQuery( '.acaai-btn-3' ).on('click', function(){
77        show_acaai_content( 3 );
78    }).hover(
79    function() {
80        show_acaai_content( 3 );
81    })
82
83    jQuery( '.acaai-btn-4' ).on('click', function(){
84        show_acaai_content( 4 );
85    }).hover(
86    function() {
87        show_acaai_content( 4 );
88    })
89
90    jQuery( '.acaai-btn-5' ).on('click', function(){
91        show_acaai_content( 5 );
92    }).hover(
93    function() {
94        show_acaai_content( 5 );
95    })
96
97    jQuery( '.acaai-btn-6' ).on('click', function(){
98        show_acaai_content( 6 );
99    }).hover(
100    function() {
101        show_acaai_content( 6 );
102    })
103
104    function show_acaai_content( item_number )
105    {
106        jQuery( '.acaai-ctn' ).each( function()
107        {
108            jQuery(this).hide();
109        });
110        jQuery( '.acaai-ctn-' + item_number ).show();
111    }
112
113});