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137 --> 138<div class="container mx-auto" style="max-width: 700px;"> 139 <h3 class="fw-bold mt-4 border-bottom pb-2">Search Variant Data</h3> 140 <div class="mt-4"> 141 <!--
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141 --> 142<form method="GET" action="https://deafnessvariationdatabase.org/search" class="w-100"> 143 <div class="d-flex align-items-center gap-2 w-100"> 144 145 <input 146 type="text" 147 class="form-control flex-grow-1 search-hover h-100" 148 name="query" 149 placeholder="Search genes or coordinates by chr:pos, chr:pos-range, chr:pos:ref>alt" 150 value="" 151 > 152 <div class="flex-shrink:0;"> 153 <select name="build" class="form-select"> 154 <option value="GRCH38" >GRCh38</option> 155 <option value="GRCH37" >GRCh37</option> 156 </select> 157 </div> 158 159 <!-- <div x-data="{ build: 'GRCH38' }" class="flex-shrink-0 h-100"> 160 <input type="hidden" name="build" x-model="build"> 161 <button 162 title="Click to switch reference" 163 type="button" 164 class="btn h-100" 165 :class="build === 'GRCH38' ? 'btn-primary' : 'btn-outline-primary'" 166 @click="build = (build === 'GRCH38') ? 'GRCH37' : 'GRCH38'" 167 x-text="build" 168 ></button> 169 </div> --> 170 171 <button type="submit" class="btn btn-primary flex-shrink-0 h-100"> 172 <i class="bi bi-search"></i> 173 </button> 174 </div> 175</form> 176 <div class="mt-3"> 177 <h5>Browse by Gene</h5> 178 <div class="home-letters"> 179 <div class="letters"> 180 <div class="letter-flex"> 181 <a 182 href="https://deafnessvariationdatabase.org/genes/a" 183 class="letter " 184 > 185 A 186 </a> 187 <a 188 href="https://deafnessvariationdatabase.org/genes/b" 189 class="letter " 190 > 191 B 192 </a> 193 <a 194 href="https://deafnessvariationdatabase.org/genes/c" 195 class="letter " 196 > 197 C 198 </a> 199 <a 200 href="https://deafnessvariationdatabase.org/genes/d" 201 class="letter " 202 > 203 D 204 </a> 205 <a 206 href="https://deafnessvariationdatabase.org/genes/e" 207 class="letter " 208 > 209 E 210 </a> 211 <a 212 href="https://deafnessvariationdatabase.org/genes/f" 213 class="letter " 214 > 215 F 216 </a> 217 <a 218 href="https://deafnessvariationdatabase.org/genes/g" 219 class="letter " 220 > 221 G 222 </a> 223 <a 224 href="https://deafnessvariationdatabase.org/genes/h" 225 class="letter " 226 > 227 H 228 </a> 229 <a 230 href="https://deafnessvariationdatabase.org/genes/i" 231 class="letter " 232 > 233 I 234 </a> 235 <a 236 href="#" 237 class="letter disabled-letter" 238 > 239 J 240 </a> 241 <a 242 href="https://deafnessvariationdatabase.org/genes/k" 243 class="letter " 244 > 245 K 246 </a> 247 <a 248 href="https://deafnessvariationdatabase.org/genes/l" 249 class="letter " 250 > 251 L 252 </a> 253 <a 254 href="https://deafnessvariationdatabase.org/genes/m" 255 class="letter " 256 > 257 M 258 </a> 259 <a 260 href="https://deafnessvariationdatabase.org/genes/n" 261 class="letter " 262 > 263 N 264 </a> 265 <a 266 href="https://deafnessvariationdatabase.org/genes/o" 267 class="letter " 268 > 269 O 270 </a> 271 <a 272 href="https://deafnessvariationdatabase.org/genes/p" 273 class="letter " 274 > 275 P 276 </a> 277 <a 278 href="#" 279 class="letter disabled-letter" 280 > 281 Q 282 </a> 283 <a 284 href="https://deafnessvariationdatabase.org/genes/r" 285 class="letter " 286 > 287 R 288 </a> 289 <a 290 href="https://deafnessvariationdatabase.org/genes/s" 291 class="letter " 292 > 293 S 294 </a> 295 <a 296 href="https://deafnessvariationdatabase.org/genes/t" 297 class="letter " 298 > 299 T 300 </a> 301 <a 302 href="https://deafnessvariationdatabase.org/genes/u" 303 class="letter " 304 > 305 U 306 </a> 307 <a 308 href="#" 309 class="letter disabled-letter" 310 > 311 V 312 </a> 313 <a 314 href="https://deafnessvariationdatabase.org/genes/w" 315 class="letter " 316 > 317 W 318 </a> 319 <a 320 href="#" 321 class="letter disabled-letter" 322 > 323 X 324 </a> 325 <a 326 href="#" 327 class="letter disabled-letter" 328 > 329 Y 330 </a> 331 <a 332 href="#" 333 class="letter disabled-letter" 334 > 335 Z 336 </a> 337 </div> 338</div> </div> 339 </div> 340 </div> 341</div> 342<br> 343<div class="container w-100" > 344<h3 class="fw-bold mt-4 border-bottom pb-2"> About</h3> 345<div class="width500"> 346 <p> 347 The <strong>Deafness Variation Database (DVD)</strong> is a public, expert-curated resource of genetic 348 variation in genes associated with hearing loss, built and maintained by the <a href="https://morl.lab.uiowa.edu" class="ui-links" target=_blank>Molecular 349 Otolaryngology & Renal Research Laboratories (MORL)</a> 350 at the University of Iowa and launched in 2011. 351 </p> 352 <p> 353 Our mission is to advance accurate classification of deafness-associated genetic variation by rigorously collating, annotating, classifying, 354 and openly sharing evidence. We aim to reduce uncertainty and enable accurate diagnosis and informed clinical decision-making. 355 </p> 356 <p> 357 <strong>Current release DVD v9.2</strong> summarizes all known variants across 224 358 deafness-associated genes represented on 359 <a href="https://morl.lab.uiowa.edu/otoscope-panel-genes" class="ui-links" target=_blank>OtoSCOPE®</a>, MORLâs comprehensive 360 genetic screening platform for deafness. 361 The DVD collates data from major public resources, annotates with gene/transcript, population, functional, and clinical context, and classifies 362 each variant to produce a single, evidence-based assessment. Classifications are reviewed by genetic hearing-loss experts at the MORL. See 363 <a href="sources" class="ui-links" target=_blank>sources</a> and our landmark paper, 364 <a href="https://doi.org/10.1016/j.ajhg.2018.08.006" class="ui-links" target=_blank>Genomic Landscape and Mutational Signatures of Deafness-Associated Genes</a> for details. 365 </p> 366 The DVD is <strong>continually curated</strong>. This version reflects our most recent interpretations. 367 </p> 368 <p> 369 The data are freely available. When using the DVD, please review our
369<a href="references" class="ui-links" target=_blank>citation policy</a>. 370 </p> 371 <p> 372 All content is copyrighted by the MORL at The University of Iowa. 373 </p> 374 <p> 375 To suggest an update or add a gene or variant, <a href="/contact" class="ui-links" target=_blank>contact us</a>. 376 </p> 377 <p> 378 Supported in part by R01 DC012049 379 </p> 380 381 <br> 382 <p>Supported in part by</br></br><a href="https://www.nidcd.nih.gov/">R01 DC012049</a></p></br> 383 <a href="https://www.nidcd.nih.gov/"> 384 <img 385 src="https://deafnessvariationdatabase.org/assets/img/logo-NIDCD.png" 386 style="max-height:50px;" 387 title="National Institute on Deafness and Other Communication Disorders" 388 alt="NIDCD Logo" 389 > 390 </a> 391</div> 392</div> 393<div class="mx-auto" style="width: 600px"> 394 </br> 395 <p> 396 <b>Follow Us!</b> 397 </p> 398 <a href="https://twitter.com/MORL_UIowa" title="MORL UIowa Twitter"> 399 <img src="https://deafnessvariationdatabase.org/assets/img/twitter.png" height="5%" width="5%" alt="Twitter" hspace="10" class="float-left" /> 400 </a> 401 <a href="https://www.facebook.com/UIMORL" title="MORL UIowa Facebook"> 402 <img src="https://deafnessvariationdatabase.org/assets/img/facebook.png" height="5%" width="5%" alt="Facebook" hspace="10" class="float-center" /> 403 </a> 404 <!-- <a href="https://morl.lab.uiowa.edu" title="MORL UIowa Website"> 405 <img src="https://deafnessvariationdatabase.org/assets/img/morl.png" height="20%" width="20%" alt="MORL" hspace="10" class="float-left" /> 406 </a> --> 407</div> 408 </main> 409</div> 410 411<div class="search-modal" id="searchModal"> 412 <div class="search-form-wrapper"> 413 <div class="mb-3"> 414 <!--
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414 --> 415<form method="GET" action="https://deafnessvariationdatabase.org/search" class="w-100"> 416 <div class="d-flex align-items-center gap-2 w-100"> 417 418 <input 419 type="text" 420 class="form-control flex-grow-1 search-hover h-100" 421 name="query" 422 placeholder="Search genes or coordinates by chr:pos, chr:pos-range, chr:pos:ref>alt" 423 value="" 424 > 425 <div class="flex-shrink:0;"> 426 <select name="build" class="form-select"> 427 <option value="GRCH38" >GRCh38</option> 428 <option value="GRCH37" >GRCh37</option> 429 </select> 430 </div> 431 432 <!-- <div x-data="{ build: 'GRCH38' }" class="flex-shrink-0 h-100"> 433 <input type="hidden" name="build" x-model="build"> 434 <button 435 title="Click to switch reference" 436 type="button" 437 class="btn h-100" 438 :class="build === 'GRCH38' ? 'btn-primary' : 'btn-outline-primary'" 439 @click="build = (build === 'GRCH38') ? 'GRCH37' : 'GRCH38'" 440 x-text="build" 441 ></button> 442 </div> --> 443 444 <button type="submit" class="btn btn-primary flex-shrink-0 h-100"> 445 <i class="bi bi-search"></i> 446 </button> 447 </div> 448</form> 449 </div> 450 <div class="d-flex justify-content-between"> 451 <button type="submit" class="btn btn-primary">Search</button> 452 <button type="button" class="btn btn-secondary" onclick="toggleSearchModal()">Cancel</button> 453 </div> 454 </div> 455</div> 456 457<div class="sidebar" id="sidebar"> 458 <div class="morl-image-wrapper"> 459 <a href="https://morl.lab.uiowa.edu" title="MORL UIowa Website" target="_blank"> 460 <img src="https://deafnessvariationdatabase.org/assets/img/morl_white_cropped.png" class="morl-image" alt="MORL Logo"/> 461 </a> 462 </div> 463 <div class="sidebar-contents mt-3"> 464 <div class="letter-table"> 465 <h6 class="border-bottom" style="color:white;">Browse by Gene</h6> 466 <div class="letters"> 467 <div class="letter-flex"> 468 <a 469 href="https://deafnessvariationdatabase.org/genes/a" 470 class="letter " 471 > 472 A 473 </a> 474 <a 475 href="https://deafnessvariationdatabase.org/genes/b" 476 class="letter " 477 > 478 B 479 </a> 480 <a 481 href="https://deafnessvariationdatabase.org/genes/c" 482 class="letter " 483 > 484 C 485 </a> 486 <a 487 href="https://deafnessvariationdatabase.org/genes/d" 488 class="letter " 489 > 490 D 491 </a> 492 <a 493 href="https://deafnessvariationdatabase.org/genes/e" 494 class="letter " 495 > 496 E 497 </a> 498 <a 499 href="https://deafnessvariationdatabase.org/genes/f" 500 class="letter " 501 > 502 F 503 </a> 504 <a 505 href="https://deafnessvariationdatabase.org/genes/g" 506 class="letter " 507 > 508 G 509 </a> 510 <a 511 href="https://deafnessvariationdatabase.org/genes/h" 512 class="letter " 513 > 514 H 515 </a> 516 <a 517 href="https://deafnessvariationdatabase.org/genes/i" 518 class="letter " 519 > 520 I 521 </a> 522 <a 523 href="#" 524 class="letter disabled-letter" 525 > 526 J 527 </a> 528 <a 529 href="https://deafnessvariationdatabase.org/genes/k" 530 class="letter " 531 > 532 K 533 </a> 534 <a 535 href="https://deafnessvariationdatabase.org/genes/l" 536 class="letter " 537 > 538 L 539 </a> 540 <a 541 href="https://deafnessvariationdatabase.org/genes/m" 542 class="letter " 543 > 544 M 545 </a> 546 <a 547 href="https://deafnessvariationdatabase.org/genes/n" 548 class="letter " 549 > 550 N 551 </a> 552 <a 553 href="https://deafnessvariationdatabase.org/genes/o" 554 class="letter " 555 > 556 O 557 </a> 558 <a 559 href="https://deafnessvariationdatabase.org/genes/p" 560 class="letter " 561 > 562 P 563 </a> 564 <a 565 href="#" 566 class="letter disabled-letter" 567 > 568 Q 569 </a> 570 <a 571 href="https://deafnessvariationdatabase.org/genes/r" 572 class="letter " 573 > 574 R 575 </a> 576 <a 577 href="https://deafnessvariationdatabase.org/genes/s" 578 class="letter " 579 > 580 S 581 </a> 582 <a 583 href="https://deafnessvariationdatabase.org/genes/t" 584 class="letter " 585 > 586 T 587 </a> 588 <a 589 href="https://deafnessvariationdatabase.org/genes/u" 590 class="letter " 591 > 592 U 593 </a> 594 <a 595 href="#" 596 class="letter disabled-letter" 597 > 598 V 599 </a> 600 <a 601 href="https://deafnessvariationdatabase.org/genes/w" 602 class="letter " 603 > 604 W 605 </a> 606 <a 607 href="#" 608 class="letter disabled-letter" 609 > 610 X 611 </a> 612 <a 613 href="#" 614 class="letter disabled-letter" 615 > 616 Y 617 </a> 618 <a 619 href="#" 620 class="letter disabled-letter" 621 > 622 Z 623 </a> 624 </div> 625</div> </div> 626 <br> 627 <dl class="nav flex-column"> 628 <dt class="nav-item"><a class="nav-link" href="/">Home</a></dt> 629 <dt class="nav-item"><a class="nav-link" href="/new">What's New</a></dt> 630 <dt class="nav-item"><a class="nav-link" href="/classification">Classification</a></dt> 631 <dt class="nav-item"><a class="nav-link" href="/nomenclature">Nomenclature</a></dt> 632 <dt class="nav-item"><a class="nav-link" href="/sources">Sources</a></dt> 633 <dt class="nav-item"><a class="nav-link" href="/references">Cite Us</a></dt> 634 <dt class="nav-item"><a class="nav-link" href="/downloads">Downloads</a></dt> 635 <dt class="nav-item"><a class="nav-link" href="/help">Help</a></dt> 636 <dt class="nav-item"><a class="nav-link" href="/contact">Contact Us</a></dt> 637 </dl> 638 </div> 639</div> 640 641<!-- <footer class="text-white bg-dark mt-5 pt-2 pb-1 small"> 642 <div class="container-fluid px-4"> 643 <div class="row align-items-center"> 644 <div class="col-md-10 text-center text-md-start"> 645 <p class="mb-0"> 646 <p><span>&copy; 2011&ndash;2026</span> <a href="http://www.medicine.uiowa.edu/morl/" title="MORL Homepage">The Molecular Otolaryngology and Renal Research Laboratories</a> at <a href="http://www.uiowa.edu" title="University of Iowa Homepage">The University of Iowa</a></p> 647 </p> 648 </div> 649 </div> 650 </div> 651</footer> 652 -->
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