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1<title>KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph)</title><meta name="description" content="Learn about KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph), an immunotherapy treatment. Talk to your doctor to find out more."/><meta name="keywords" content="injection, subcutaneous, qlex"/><link rel="canonical" href="https://www.keytruda.com/qlex/"/><link rel="apple-touch-icon" href="/apple-touch-icon.png"/><link rel="icon" type="image/png" sizes="32x32" href="/favicon-32x32.png"/><link rel="icon" type="image/png" sizes="16x16" href="/favicon-16x16.png"/>
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1<script type="application/ld+json">{"@context":"https://schema.org/","url":"https://www.keytruda.com/qlex/","@type":"FAQPage","mainEntity":[{"@type":"Question","name":"What is KEYTRUDA QLEX?","acceptedAnswer":{"@type":"Answer","text":"KEYTRUDA QLEX is an injectable immunotherapyânot a chemotherapyâwhich contains KEYTRUDA and berahyaluronidase alfa. Berahyaluronidase alfa allows KEYTRUDA to be absorbed into your body more easily when given as a subcutaneous injection. You and your healthcare provider can choose either your stomach area or thigh for the injection."}},{"@type":"Question","name":"If Iâve already started on KEYTRUDA, can I ask my doctor to switch to KEYTRUDA QLEX?","acceptedAnswer":{"@type":"Answer","text":"Your doctor can help you decide if switching from KEYTRUDA to KEYTRUDA QLEX is right for you at any time during your treatment."}},{"@type":"Question","name":"How is KEYTRUDA QLEX given?","acceptedAnswer":{"@type":"Answer","text":"Administered in 1 or 2 minutes* as an injection given just under the skin in the stomach area or thigh by a healthcare provider."}},{"@type":"Question","name":"How does subcutaneous injection work?","acceptedA
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41.2663 347.575 40.5681 349.026 40.5681C351.605 40.5681 352.408 42.292 352.408 44.5676V53.4414H350.978L350.983 53.4371Z" fill="#808184"></path><path d="M269.866 5.55966H268.471V4.62444H272.32V5.55966H270.925V9.279H269.862V5.55966H269.866ZM273.305 4.62013H274.424L275.65 6.58539L276.877 4.62013H277.97V9.27469H276.972V6.13286L275.685 8.17569H275.594L274.307 6.13286V9.27469H273.309V4.62013H273.305Z" fill="#7C02BB"></path></g><defs><clipPath id="clip0_247_66919"><rect width="352.927" height="76.0855" fill="white" transform="translate(0.00537109)"></rect></clipPath></defs></svg></a></div></div><div class="d-none d-lg-flex flex-row align-items-lg-center gap--40 "><div class="key-container d-flex flex-column align-items-center text-center"><p class="key-text mb-1">85-KEYTRUDA</p><a class="key-link" href="#">(855-398-7832)</a></div><nav><button class="globalNavigation__navWrapper--mobileIcon" data-design-category="top_nav_vd"><svg width="33" height="25" viewBox="0 0 33 25" fill="none" 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class="number">(855-398-7832)</span></a></li><div class="globalNavigation__navWrapper--navLinksContainer--closeNav"><button type="button" class="primary-button d-block d-lg-none " data-design-category="button_vd"><span>Close Menu</span></button></div></ul></div><div class="megaMenu hidePopup"><div class="container"><div class="globalFooter__wrapper__links-container container"><div class="row"><div class="col-lg-4 col-md-6 col-12 ps-0"><div class="globalFooter__wrapper__links-container--block"><h5 class="globalFooter__title">Treatment Overview</h5><ul><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="How treatment works" href="/how-do-keytruda-and-keytruda-qlex-work/"><span aria-hidden="false">How treatment works</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="How KEYTRUDA is administered" href="/taking-keytruda/"><span aria-hidden="false">How KEYTRUDA is administered</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="How KEYTRUDA QLEX is administered" href="/taking-qlex/"><span aria-hidden="false">How KEYTRUDA QLEX is administered</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="Get to know KEYTRUDA QLEX" href="/qlex/"><span aria-hidden="false">Get to know KEYTRUDA QLEX</span></a></li></ul></div></div><div class="col-lg-4 col-md-6 col-12"><div class="globalFooter__wrapper__links-container--block header-part"><h5 class="globalFooter__title">Results for KEYTRUDA</h5><ul><li><a target="_self" 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aria-labelledby="Cost, insurance & financial help for KEYTRUDA" href="/financial-support/"><span aria-hidden="false">Cost, insurance & financial help for KEYTRUDA</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="Cost, insurance & financial help for KEYTRUDA QLEX" href="/qlex/cost/"><span aria-hidden="false">Cost, insurance & financial help for KEYTRUDA QLEX</span></a></li></ul></div></div><div class="col-lg-4 col-md-6 col-12 pe-0 ps-md-0 ps-lg-2"><div class="globalFooter__wrapper__links-container--block"><h5 class="globalFooter__title">Resources & Support </h5><ul><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="Getting started with treatment" href="/getting-started-with-keytruda-or-keytruda-qlex/"><span aria-hidden="false">Getting started with treatment</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="What to know during treatment" href="/what-to-know-during-treatment-with-keytruda-and-keytruda-qlex/"><span aria-hidden="false">What to know during treatment</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="Patient and caregiver resource library" href="/patient-and-caregiver-resources/"><span aria-hidden="false">Patient and caregiver resource library</span></a></li><li><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="top_nav_vd" aria-labelledby="Frequently asked questions" href="/keytruda-and-keytruda-qlex-faq/"><span aria-hidden="false">Frequently asked questions</span></a></li></ul></div></div></div></div></div></div><div></div><div class="hiddenClinicalPopup opacity-0 visually-hidden">
5Hidden Link</div></header><main class="qsub-page main-header" id="main-content"><div class="qsub-homepage"><section class="spacer-24--b spacer-32__mob--b"><div class="headerHomepage__wrapper qsub-homepage"><div class="container"><picture><source media="(max-width: 992px)" srcSet="/banner/qsub-hero-banner-mob.png"/><img src="/banner/qlex-homepage.png?h=auto&w=800&q=100" alt="" class="headerHomepage__wrapper--bannerImg"/></picture><div class="row"><div class="col-lg-5"><div class="headerHomepage__wrapper__content"><h1 class="headerHomepage__wrapper__content--h1"><span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX</span>âgiven in 1 or 2 minutes*</h1><p class="headerHomepage__wrapper__content--p"><strong>A subcutaneous injection given just under the skin by your healthcare provider in 1 minute every 3 weeks or 2 minutes every 6 weeks in the stomach area or thigh.</strong><span class="d-block spacer-16--t astrick-qlex"><strong>Injection time only. Not total appointment time.</strong></span></p><p class="headerHomepage__wrapper__content--h3"><span>IT'S TRU. <span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX.</span></span></p></div></div></div></div></div></section><section class="spacer-24--b spacer-32__mob--b"><div class="layoutBox__wrapper "><div class="container"><div class="anchorLinks__wrapper"><h2 class="anchorLinks__wrapper--title">On this page:</h2><ul class="anchorLinks__wrapper--links"><li class="anchorLinks__wrapper--links__item"><a class="secondary-button secondary-button__anchor anchorLinks__wrapper--links__item--link " data-design-category="content_link_vd" aria-label="What is KEYTRUDA QLEX?" href="#what-is-keytruda-qlex"><span>What is KEYTRUDA QLEX?</span></a></li><li class="anchorLinks__wrapper--links__item"><a class="secondary-button secondary-button__anchor anchorLinks__wrapper--links__item--link " data-design-category="content_link_vd" aria-label="Getting started with KEYTRUDA QLEX" href="#getting-started-with-keytruda-qlex"><span>Getting started with KEYTRUDA QLEX</span></a></li><li class="anchorLinks__wrapper--links__item"><a class="secondary-button secondary-button__anchor anchorLinks__wrapper--links__item--link " data-design-category="content_link_vd" aria-label="Frequently asked questions about KEYTRUDA QLEX" href="#frequently-asked-questions"><span>Frequently asked questions about KEYTRUDA QLEX</span></a></li></ul></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><div class="textBlock__wrapper"><div class="textBlock__wrapper--content"><h2 class="heading-h2 qsub-flex spacer-8--b" id="what-is-keytruda-qlex"><span>What is <span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX?</span></span><div class="popover-wrapper"><i class="m-4 icons simple-icons info-default info-icon icon-margin " tabindex="0"></i></div></h2><p class="spacer-8--b spacer-0__mob--b"><strong>KEYTRUDA QLEX</strong> <span class="word-with-image " style="margin:0 2px;display:inline-flex;align-items:center" tabindex="0"><audio src="/Patient/Keytruda-Qlex-Pronunciation.wav" preload="auto"></audio></span> is an injectable immunotherapyânot a chemotherapyâwhich contains KEYTRUDA and berahyaluronidase alfa. Berahyaluronidase alfa allows KEYTRUDA to be absorbed into your body more easily when given as a subcutaneous injection. You and your healthcare provider can choose either your stomach area or thigh for the injection.</p><div class="SimpleIconBulletList__wrapper"><div class="SimpleIconBulletList__wrapper--lists"><div class="SimpleIconBulletList__wrapper--lists--list"><i class="icons simple-icons green-check-search"></i><p class="SimpleIconBulletList__wrapper--lists--list--content">What to know about <a class="ContentLink--link" data-design-category="content_link_vd" href="/side-effects/">side effects</a>. Consult your doctor right away if you experience any.</p></div></div></div></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><div class="qsubdosing-comparison false"><div class="gradient-image"><h2 class="qsub-dosing--title text-center padding-spacer-24--y">A faster way to receive your treatment compared to KEYTRUDA </h2></div><div class="border-qsub no-top-border"><div class="QsubGraphic__wrapper CustomStyleQsubGraphic"><h2 class="QsubGraphic__wrapper--heading"><span class="highlighted--greenSec">KEYTRUDA</span> <span class="highlighted--qsubPurple">QLEX</span> is</h2><h3 class="QsubGraphic__wrapper--subHeading">Administered in 1 or 2 minutes* as an injection given just under the skin in the stomach area or thigh by a healthcare provider.</h3><div class="QsubGraphic__wrapper--container"><div class="QsubGraphic__wrapper--leftContainer"><div><h3 class="heading-h3 spacer-16--y text-center"><span class="highlighted--qsubPurple d-block">1-minute</span> injection</h3><hr class="divider"/><img class="spacer-16--b" width="79" height="73" src="/svgIcons/week-3-calendar.svg" alt="Every 3 weeks"/></div></div><div class="QsubGraphic__wrapper--middleContainer">OR</div><div class="QsubGraphic__wrapper--rightContainer"><div><h3 class="heading-h3 spacer-16--y text-center"><span class="highlighted--qsubPurple d-block">2-minute</span> injection</h3><hr class="divider"/><img class="spacer-16--b" width="79" height="73" src="/svgIcons/week-6-calendar.svg" alt="Every 6 weeks"/></div> </div></div><div class="QsubGraphic__wrapper--content"><div class="d-flex flex-column justify-content-center align-items-center text-center"><p>*Injection time only. Not total appointment time.</p><p>Your doctor will decide how many treatments you need.</p></div><div class="qsub-divider"></div><div class="SimpleIconBulletList__wrapper"><div class="SimpleIconBulletList__wrapper--lists"><div class="SimpleIconBulletList__wrapper--lists--list"><i class="icons simple-icons green-iv"></i><p class="SimpleIconBulletList__wrapper--lists--list--content"><strong>For comparison, infusion with KEYTRUDA is given into your vein through an intravenous (IV) line by a healthcare provider over 30 minutes, every 3 or 6 weeks. In children, KEYTRUDA is usually given every 3 weeks.</strong></p></div></div></div></div></div></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><div class="textBlock__wrapper"><div class="textBlock__wrapper--content"><h3 class="heading-h3 spacer-8--b">In a clinical trial, <span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX</span> was comparable to <span class="highlighted">KEYTRUDA</span></h3><p class="spacer-8--b">In a clinical trial, 377 patients with advanced nonâsmall cell lung cancer (NSCLC) received either KEYTRUDA QLEX every 6 weeks + chemotherapy (251 patients) or KEYTRUDA every 6 weeks + chemotherapy (126 patients). All patients in the trial had no previous drug treatment and did not have an abnormal EGFR, ALK, or ROS1 gene.</p><ul class="base-ul spacer-0--b"><li>People who received either treatment were shown to have similar amounts of medicine in the blood. (This was studied to determine whether the subcutaneous injection is comparable to the infusion.)</li></ul><p>In that same clinical trial, results also found that:</p><ul class="base-ul mb-0"><li>KEYTRUDA QLEX had consistent safety with KEYTRUDA.</li></ul><p class="spacer-8--t">During treatment with KEYTRUDA QLEX, <a class="ContentLink--link" data-design-category="content_link_vd" href="/side-effects/">side effects can occur</a> and should be treated as early as possible. In clinical trials with KEYTRUDA QLEX, some patients stopped treatment due to side effects. Tell your doctor if you have any side effect that bothers you or that does not go away.</p></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><div class="text-center spacer-24--b spacer-16__mob--b"><img alt="" loading="lazy" width="210" height="78" decoding="async" data-nimg="1" style="color:transparent" srcSet="/svgIcons/injection-icon.svg?h=undefined&w=256&q=75 1x, /svgIcons/injection-icon.svg?h=undefined&w=640&q=75 2x" src="/svgIcons/injection-icon.svg?h=undefined&w=640&q=75"/></div><div class="textBlock__wrapper"><div class="textBlock__wrapper--content"><h3 class="heading-h3 "><span>If Iâve already started on <span class="highlighted"><span class="highlighted">KEYTRUDA</span></span>, can I ask my doctor to switch to <span class="highlighted"><span class="highlighted">KEYTRUDA</span></span> <span class="purplehighlighted">QLEX?</span></span></h3><p>Your doctor can help you decide if switching from KEYTRUDA to KEYTRUDA QLEX is right for you at any time during your treatment.</p></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><div class="textBlock__wrapper"><div class="textBlock__wrapper--content"><h2 class="heading-h2 spacer-24--b spacer-16__mob--b" id="getting-started-with-keytruda-qlex"><span>Getting started with <span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX</span></span></h2></div></div><div class="video-player-container"><div class="row"><div class="col-md-9 col-12 video-player"><h4 class="heading-h4">Questions to ask before your first treatment appointment</h4>
5<div class="brightcove-react-player-loader"></div></div><div class="col-md-3 col-12 video-list three-videos-layout"><h5 class="heading-h5">Watch next:</h5><ol><li data-video-id="6376871677112"><button type="button" class=""><img src="/videos/Thumbnail-Qlex-1.png" alt="Questions to Ask Before Your First Treatment Appointment With KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph)"/><p class="large-title" aria-hidden="true">Questions to ask before your first treatment appointment</p><span class="thumbnail-btn"></span></button></li><li data-video-id="6376872656112"><button type="button" class=""><img src="/videos/Thumbnail-Qlex-2.png" alt="Preparing for Your First Treatment Appointment With KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph)"/><p class="large-title" aria-hidden="true">Preparing for your first treatment appointment</p><span class="thumbnail-btn"></span></button></li><li data-video-id="6376870826112"><button type="button" class=""><img src="/videos/Thumbnail-Qlex-3.png" alt="Track How You Feel After the Administration of KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph)"/><p class="large-title" aria-hidden="true">Track how you feel after treatment</p><span class="thumbnail-btn"></span></button></li></ol></div></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper qsub-accordion"><div class="bg--gray-white"><div class="container"><div class="layoutBox__wrapper--container qsub-accordion"><h2 class="heading-h2 spacer-8--b" id="frequently-asked-questions"><span>Frequently asked questions about <span class="highlighted">KEYTRUDA</span> <span class="purplehighlighted">QLEX</span></span></h2><p class="spacer-24--b">Every patient is different. You should speak with your doctor to understand your treatment optionsâand find out if KEYTRUDA QLEX is right for you.</p><div class="accordion__wrapper"><div class="accordion"><div id="how-is-keytruda-qlex-given" class="accordion-item"><h2 class="qsub accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">How is KEYTRUDA QLEX given?</button></h2><div class="accordion-collapse collapse"><div class="accordion-body"><div class="d-flex flex-column gap--8"><div class="spacer-24--t spacer-8__mob--t spacer-24--b spacer-16__mob--b"><div class="qsubdosing-comparison false"><div class="QsubGraphic__wrapper CustomStyleQsubGraphic padding-0"><h2 class="QsubGraphic__wrapper--heading"><span class="highlighted--greenSec">KEYTRUDA</span> <span class="highlighted--qsubPurple">QLEX</span> is</h2><h3 class="QsubGraphic__wrapper--subHeading">Administered in 1 or 2 minutes* as an injection given just under the skin in the stomach area or thigh by a healthcare provider.</h3><div class="QsubGraphic__wrapper--container"><div class="QsubGraphic__wrapper--leftContainer"><div><h3 class="heading-h3 spacer-16--y text-center"><span class="highlighted--qsubPurple d-block">1-minute</span> injection</h3><hr class="divider"/><img class="spacer-16--b" width="79" height="73" src="/svgIcons/week-3-calendar.svg" alt="Every 3 Weeks"/></div></div><div class="QsubGraphic__wrapper--middleContainer">OR</div><div class="QsubGraphic__wrapper--rightContainer"><div><h3 class="heading-h3 spacer-16--y text-center"><span class="highlighted--qsubPurple d-block">2-minute</span> injection</h3><hr class="divider"/><img class="spacer-16--b" width="79" height="73" src="/svgIcons/week-6-calendar.svg" alt="Every 6 Weeks"/></div> </div></div><div class="QsubGraphic__wrapper--content"><div class="d-flex flex-column justify-content-center align-items-center text-center"><p>*Injection time only. Not total appointment time.</p><p>Your doctor will decide how many treatments you need.</p></div></div></div></div></div><p class="spacer-8--b">KEYTRUDA QLEX is given as an injection under the skin, not into a vein. That is why port surgery is not required. Itâs important to note that you may still need a port if your treatment plan involves another treatment, such as chemotherapy. </p><p class="spacer-24--b">KEYTRUDA QLEX also gives you the ability to choose where you get your injection: in the stomach area or thigh.</p><p class="spacer-8--b"><strong>KEYTRUDA QLEX is a faster way to receive your treatment compared to KEYTRUDA.</strong></p><ul class="base-ul custom-ul"><li>Your doctor will give you KEYTRUDA into your vein through an intravenous (IV) line. Treatments are <strong>given over 30 minutes</strong>. Treatments usually take place at your doctorâs office or an infusion clinic.</li><li class="mb-0">In adults with <a class="ContentLink--link" data-design-category="button_vd" href="">certain cancers</a>, KEYTRUDA is usually given every <strong>3 weeks or every 6 weeks,</strong> depending on the dose that you are receiving. In children, KEYTRUDA is usually given <strong>every 3 weeks</strong>.</li></ul><div class="dosingOptionsCallout__hourglass spacer-16--t"><i class="icons illustrative-icons ill-hourglass"></i><p><b>30 minutes per intravenous infusion</b></p></div><div class="dosingOptionsCallout__weeks spacer-16--b spacer-8__mob--b"><div class="dosingOptionsCallout__weeks__weekCount"><svg width="82" height="83" viewBox="0 0 82 83" fill="none" xmlns="http://www.w3.org/2000/svg"><title>Every 3 Weeks</title><path d="M69.5238 9H74.2348C77.7308 9 80.5652 12.1129 80.5652 15.9524V75.0476C80.5652 78.8871 77.7308 82 74.2348 82H7.76525C4.26927 82 1.43481 78.8871 1.43481 75.0476V15.9524C1.43481 12.1129 4.26927 9 7.76525 9H12.4763" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path d="M66.2645 25.5H80.5652" stroke="#444444" stroke-width="2"></path><path d="M1.43481 25.5H15.7355" stroke="#444444" stroke-width="2"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M19.549 12.6667C19.549 14.5067 17.8406 16 15.7355 16C13.6305 16 11.922 14.5067 11.922 12.6667V4.33333C11.922 2.49333 13.6305 1 15.7355 1C17.8406 1 19.549 2.49333 19.549 4.33333V12.6667Z" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M69.1247 12.6667C69.1247 14.5067 67.4163 16 65.3112 16C63.2061 16 61.4977 14.5067 61.4977 12.6667V4.33333C61.4977 2.49333 63.2061 1 65.3112 1C67.4163 1 69.1247 2.49333 69.1247 4.33333V12.6667Z" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path d="M41 59C36.7996 59 33.6821 57.4325 31.9429 55.3425L34.7978 51.2671C36.4058 52.9042 38.867 53.7054 40.7703 53.7054C43.1986 53.7054 44.4456 52.73 44.4456 51.4412C44.4456 50.1176 43.5268 49.4557 40.5406 49.4557C39.5889 49.4557 37.9153 49.4906 37.5871 49.5254V44.1959C38.0138 44.2308 39.7202 44.2308 40.5406 44.2308C42.8048 44.2308 44.0846 43.6386 44.0846 42.4194C44.0846 40.9565 42.5095 40.2946 40.4093 40.2946C38.4075 40.2946 36.5042 41.061 34.9619 42.5239L32.2382 38.762C34.1087 36.5675 36.9637 35 41 35C46.5786 35 49.6961 37.5428 49.6961 41.3745C49.6961 44.0914 47.4975 46.1466 44.905 46.5994C47.2349 46.8433 50.0571 48.7591 50.0571 52.103C50.0571 56.1785 46.4474 59 41 59Z" fill="#449C44"></path><path d="M29.1503 30H21.3263V19.328H29.1503V21.728H24.0783V23.392H29.0383V25.792H24.0783V27.6H29.1503V30ZM35.3493 30H32.7253L29.6853 22.272H32.2773L34.0213 27.168L35.7813 22.272H38.3893L35.3493 30ZM42.9011 30.192C40.5171 30.192 38.6771 28.64 38.6771 26.128C38.6771 23.888 40.3731 22.08 42.7891 22.08C45.0771 22.08 46.7411 23.76 46.7411 26.384V26.912H41.2371C41.3811 27.632 42.0531 28.288 43.1731 28.288C43.7171 28.288 44.6611 28.048 45.0931 27.632L46.1331 29.168C45.3651 29.856 44.0851 30.192 42.9011 30.192ZM44.3891 25.312C44.3251 24.768 43.9251 23.984 42.7891 23.984C41.7171 23.984 41.3011 24.752 41.2051 25.312H44.3891ZM50.4759 30H48.0119V22.272H50.4759V23.216C50.9879 22.592 51.9639 22.064 52.8919 22.064V24.432C52.7479 24.4 52.5399 24.368 52.2839 24.368C51.6439 24.368 50.7959 24.64 50.4759 25.072V30ZM53.909 33.008L54.261 30.816C54.437 30.912 54.677 30.96 54.869 30.96C55.429 30.96 55.781 30.848 55.909 30.528L56.085 30.112L53.013 22.272H55.605L57.349 27.168L59.109 22.272H61.717L58.229 31.104C57.605 32.736 56.437 33.104 54.965 33.136C54.741 33.136 54.165 33.088 53.909 33.008Z" fill="#444444"></path><path d="M28.4158 74H25.7598L24.3038 69.216L22.8638 74H20.2078L17.9198 66.272H20.4478L21.6958 71.008L23.2158 66.272H25.4078L26.9278 71.008L28.1598 66.272H30.7038L28.4158 74ZM35.2747 74.192C32.8907 74.192 31.0507 72.64 31.0507 70.128C31.0507 67.888 32.7467 66.08 35.
51627 66.08C37.4507 66.08 39.1147 67.76 39.1147 70.384V70.912H33.6107C33.7547 71.632 34.4267 72.288 35.5467 72.288C36.0907 72.288 37.0347 72.048 37.4667 71.632L38.5067 73.168C37.7387 73.856 36.4587 74.192 35.2747 74.192ZM36.7627 69.312C36.6987 68.768 36.2987 67.984 35.1627 67.984C34.0907 67.984 33.6747 68.752 33.5787 69.312H36.7627ZM44.0975 74.192C41.7135 74.192 39.8735 72.64 39.8735 70.128C39.8735 67.888 41.5695 66.08 43.9855 66.08C46.2735 66.08 47.9375 67.76 47.9375 70.384V70.912H42.4335C42.5775 71.632 43.2495 72.288 44.3695 72.288C44.9135 72.288 45.8575 72.048 46.2895 71.632L47.3295 73.168C46.5615 73.856 45.2815 74.192 44.0975 74.192ZM45.5855 69.312C45.5215 68.768 45.1215 67.984 43.9855 67.984C42.9135 67.984 42.4975 68.752 42.4015 69.312H45.5855ZM57.1443 74H54.1043L52.4083 71.264L51.6723 72.144V74H49.2083V63.328H51.6723V69.36L54.0243 66.272H57.0003L54.1523 69.792L57.1443 74ZM60.9598 74.192C59.5838 74.192 58.1598 73.728 57.3438 73.008L58.3678 71.312C58.9438 71.824 60.1758 72.336 61.0878 72.336C61.8238 72.336 62.1278 72.096 62.1278 71.744C62.1278 70.736 57.6318 71.728 57.6318 68.624C57.6318 67.264 58.7998 66.08 60.9438 66.08C62.2398 66.08 63.3438 66.496 64.1758 67.104L63.2318 68.736C62.7678 68.288 61.8878 67.888 60.9598 67.888C60.3838 67.888 59.9838 68.128 59.9838 68.448C59.9838 69.344 64.4798 68.464 64.4798 71.632C64.4798 73.104 63.1838 74.192 60.9598 74.192Z" fill="#444444"></path><path d="M19.5491 9.5H62.4511" stroke="#444444" stroke-width="2"></path></svg></div><svg xmlns="http://www.w3.org/2000/svg" width="64" height="64" viewBox="0 0 64 64" fill="none"><title>Or</title><circle cx="32" cy="32" r="32" fill="#449C44"></circle><path fill-rule="evenodd" clip-rule="evenodd" d="M17.0001 32C17.0001 36.7072 20.3433 40 24.8009 40C29.2585 40 32.5798 36.7072 32.5798 32C32.5798 27.2928 29.2585 24 24.8009 24C20.3433 24 17.0001 27.2928 17.0001 32ZM28.9566 32.0001C28.9566 34.5582 27.3976 36.5716 24.9821 36.5716C22.5666 36.5716 20.9856 34.5582 20.9856 32.0001C20.9856 29.4183 22.5666 27.4287 24.9821 27.4287C27.3976 27.4287 28.9566 29.4183 28.9566 32.0001ZM47.4349 39.9999H43.0444L40.5483 34.7545H38.587V39.9999H34.7537V24.3809H42.1975C45.4959 24.3809 47.368 26.6757 47.368 29.5794C47.368 32.2958 45.8079 33.7476 44.4039 34.2628L47.4349 39.9999ZM43.4494 29.7036C43.4494 30.7052 42.6536 31.238 41.6643 31.238H38.7392V28.1904H41.6643C42.6536 28.1904 43.4494 28.7232 43.4494 29.7036Z" fill="white"></path></svg><div class="dosingOptionsCallout__weeks__weekCount"><svg width="82" height="83" viewBox="0 0 82 83" fill="none" xmlns="http://www.w3.org/2000/svg"><title>Every 6 Weeks</title><path d="M69.5238 9H74.2348C77.7308 9 80.5652 12.1129 80.5652 15.9524V75.0476C80.5652 78.8871 77.7308 82 74.2348 82H7.76525C4.26927 82 1.43481 78.8871 1.43481 75.0476V15.9524C1.43481 12.1129 4.26927 9 7.76525 9H12.4763" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path d="M66.2645 25.5H80.5652" stroke="#444444" stroke-width="2"></path><path d="M1.43481 25.5H15.7355" stroke="#444444" stroke-width="2"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M20.5024 12.6667C20.5024 14.5067 18.7939 16 16.6889 16C14.5838 16 12.8754 14.5067 12.8754 12.6667V4.33333C12.8754 2.49333 14.5838 1 16.6889 1C18.7939 1 20.5024 2.49333 20.5024 4.33333V12.6667Z" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M70.0781 12.6667C70.0781 14.5067 68.3696 16 66.2646 16C64.1595 16 62.451 14.5067 62.451 12.6667V4.33333C62.451 2.49333 64.1595 1 66.2646 1C68.3696 1 70.0781 2.49333 70.0781 4.33333V12.6667Z" stroke="#444444" stroke-width="2" stroke-linejoin="round"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M31.9429 47.0174C31.9429 53.6705 34.8717 59 41.5889 59C46.5234 59 50.0571 55.6212 50.0571 50.8491C50.0571 45.9028 46.5234 43.2206 42.7031 43.2206C40.5702 43.2206 38.5327 44.3353 37.4822 45.8679V45.5893C37.4822 42.3498 39.8698 40.2946 42.4803 40.2946C44.1994 40.2946 45.3773 40.7823 46.5552 41.8273L48.911 37.2293C47.3192 35.8708 44.9634 35 42.4803 35C36.0496 35 31.9429 39.598 31.9429 47.0174ZM44.5617 51.0516C44.5617 52.3247 43.3046 53.6667 41.2417 53.6667C38.6308 53.6667 37.5994 51.7398 37.4382 49.8817C38.373 48.8151 39.6945 48.3333 41.0483 48.3333C42.7245 48.3333 44.5617 49.1247 44.5617 51.0516Z" fill="#449C44"></path><path d="M30.09 30H22.266V19.328H30.09V21.728H25.018V23.392H29.978V25.792H25.018V27.6H30.09V30Z
5M36.289 30H33.665L30.625 22.272H33.217L34.961 27.168L36.721 22.272H39.329L36.289 30ZM43.8408 30.192C41.4568 30.192 39.6168 28.64 39.6168 26.128C39.6168 23.888 41.3128 22.08 43.7288 22.08C46.0168 22.08 47.6808 23.76 47.6808 26.384V26.912H42.1768C42.3208 27.632 42.9928 28.288 44.1128 28.288C44.6568 28.288 45.6008 28.048 46.0328 27.632L47.0728 29.168C46.3048 29.856 45.0248 30.192 43.8408 30.192ZM45.3288 25.312C45.2648 24.768 44.8648 23.984 43.7288 23.984C42.6568 23.984 42.2408 24.752 42.1448 25.312H45.3288ZM51.4156 30H48.9516V22.272H51.4156V23.216C51.9276 22.592 52.9036 22.064 53.8316 22.064V24.432C53.6876 24.4 53.4796 24.368 53.2236 24.368C52.5836 24.368 51.7356 24.64 51.4156 25.072V30ZM54.8487 33.008L55.2007 30.816C55.3767 30.912 55.6167 30.96 55.8087 30.96C56.3687 30.96 56.7207 30.848 56.8487 30.528L57.0247 30.112L53.9527 22.272H56.5447L58.2887 27.168L60.0487 22.272H62.6567L59.1687 31.104C58.5447 32.736 57.3767 33.104 55.9047 33.136C55.6807 33.136 55.1047 33.088 54.8487 33.008Z" fill="#444444"></path><path d="M29.3555 74H26.6995L25.2435 69.216L23.8035 74H21.1475L18.8595 66.272H21.3875L22.6355 71.008L24.1555 66.272H26.3475L27.8675 71.008L29.0995 66.272H31.6435L29.3555 74ZM36.2144 74.192C33.8304 74.192 31.9904 72.64 31.9904 70.128C31.9904 67.888 33.6864 66.08 36.1024 66.08C38.3904 66.08 40.0544 67.76 40.0544 70.384V70.912H34.5504C34.6944 71.632 35.3664 72.288 36.4864 72.288C37.0304 72.288 37.9744 72.048 38.4064 71.632L39.4464 73.168C38.6784 73.856 37.3984 74.192 36.2144 74.192ZM37.7024 69.312C37.6384 68.768 37.2384 67.984 36.1024 67.984C35.0304 67.984 34.6144 68.752 34.5184 69.312H37.7024ZM45.0372 74.192C42.6532 74.192 40.8132 72.64 40.8132 70.128C40.8132 67.888 42.5092 66.08 44.9252 66.08C47.2132 66.08 48.8772 67.76 48.8772 70.384V70.912H43.3732C43.5172 71.632 44.1892 72.288 45.3092 72.288C45.8532 72.288 46.7972 72.048 47.2292 71.632L48.2692 73.168C47.5012 73.856 46.2212 74.192 45.0372 74.192ZM46.5252 69.312C46.4612 68.768 46.0612 67.984 44.9252 67.984C43.8532 67.984 43.4372 68.752 43.3412 69.312H46.5252ZM58.084 74H55.044L53.348 71.264L52.612 72.144V74H50.148V63.328H52.612V69.36L54.964 66.272H57.94L55.092 69.792L58.084 74ZM61.8995 74.192C60.5235 74.192 59.0995 73.728 58.2835 73.008L59.3075 71.312C59.8835 71.824 61.1155 72.336 62.0275 72.336C62.7635 72.336 63.0675 72.096 63.0675 71.744C63.0675 70.736 58.5715 71.728 58.5715 68.624C58.5715 67.264 59.7395 66.08 61.8835 66.08C63.1795 66.08 64.2835 66.496 65.1155 67.104L64.1715 68.736C63.7075 68.288 62.8275 67.888 61.8995 67.888C61.3235 67.888 60.9235 68.128 60.9235 68.448C60.9235 69.344 65.4195 68.464 65.4195 71.632C65.4195 73.104 64.1235 74.192 61.8995 74.192Z" fill="#444444"></path><path d="M19.549 9.5H62.451" stroke="#444444" stroke-width="2"></path></svg></div></div><p class="text-center">Your doctor will decide how many treatments you need, based on your experience with KEYTRUDA.</p></div></div></div></div><div id="how-does-subcutaneous-injection-work" class="accordion-item"><h2 class="qsub accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">How does subcutaneous injection work?</button></h2><div class="accordion-collapse collapse"><div class="accordion-body"><div class="d-flex flex-column gap--8"><p>KEYTRUDA QLEX is a subcutaneous immunotherapy that is injected under the skin by a healthcare provider.</p><p class="spacer-8--t">In this type of injection, a short needle is used to inject the medication just under the skin, into the fatty tissue layer between the skin and the muscle in the stomach area or thigh.</p><div class=""><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="How KEYTRUDA QLEX is administered" href="/taking-qlex/"><span aria-hidden="false">How KEYTRUDA QLEX is administered</span></a></div></div></div></div></div><div id="what-are-the-subcutaneous-injection-sites" class="accordion-item"><h2 class="qsub accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">What are the subcutaneous injection sites?</button></h2><div class="accordion-collapse collapse"><div class="accordion-body"><div class="d-flex flex-column gap--8"><p>KEYTRUDA QLEX is a subcutaneous (under the skin) injection that is injected in the stomach area or thigh.</p><p class="spacer-8--t">KEYTRUDA QLEX is given as an injection under the skin, not into a vein. That is
5why port surgery is not required. Itâs important to note that you may still need a port if your treatment plan involves another treatment, such as chemotherapy.</p><div class=""><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="How KEYTRUDA QLEX is administered" href="/taking-qlex/"><span aria-hidden="false">How KEYTRUDA QLEX is administered</span></a></div></div></div></div></div><div id="if-ive-already-started-on-keytruda-can-i-ask-my-doctor-to-switch-to-keytruda-qlex" class="accordion-item"><h2 class="qsub accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">If Iâve already started on KEYTRUDA, can I ask my doctor to switch to KEYTRUDA QLEX?</button></h2><div class="accordion-collapse collapse"><div class="accordion-body"><div class="d-flex flex-column gap--8"><p>Your doctor can help you decide if switching from KEYTRUDA to KEYTRUDA QLEX is right for you at any time during your treatment.</p><p class="spacer-8--t">You may need to contact your insurance company for information about your coverage.</p><div class=""><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="Cost, insurance & financial help for KEYTRUDA" href="/financial-support/"><span aria-hidden="false">Cost, insurance & financial help for KEYTRUDA</span></a></div><div><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="Cost, insurance & financial help for KEYTRUDA QLEX" href="/qlex/cost/"><span aria-hidden="false">Cost, insurance & financial help for KEYTRUDA QLEX</span></a></div></div></div></div></div><div id="how-should-i-prepare-for-my-first-treatment-appointment" class="accordion-item"><h2 class="qsub accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">How should I prepare for my first treatment appointment?</button></h2><div class="accordion-collapse collapse"><div class="accordion-body"><div class="d-flex flex-column gap--8"><p>When starting a new medication, it can be reassuring to know what to expect. Preparing for your first subcutaneous (under the skin) injection appointment, including thinking through what to bring and what to keep in mind, may help. </p><p class="spacer-8--t">Explore practical tips to help you prepare before your appointment, during your appointment, and after your appointment. Learn more about how KEYTRUDA QLEX is given:</p><div class=""><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="How KEYTRUDA QLEX is administered" href="/taking-qlex/"><span aria-hidden="false">How KEYTRUDA QLEX is administered</span></a></div><div class=""><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="Patient and caregiver resource library" href="/patient-and-caregiver-resources/"><span aria-hidden="false">Patient and caregiver resource library</span></a></div></div></div></div></div></div></div></div></div></div></div></section><section class="section-spacing"><div class="layoutBox__wrapper "><div class="container"><h3 class="heading-h4 spacer-16--b">You also might be interested in:</h3><div class="row"><div class="col-lg-4 col-md-4"><div class="relatedLinksCards__wrapper"><ul class="listtypenone"><li><a target="_self" class="secondary-button relatedLinksCards__wrapper--secondaryBtn secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="How KEYTRUDA QLEX is administered" href="/taking-qlex/"><span aria-hidden="false">How KEYTRUDA QLEX is administered</span></a><br/>
5</li></ul></div></div><div class="col-lg-4 col-md-4"><div class="relatedLinksCards__wrapper"><ul class="listtypenone"><li><a target="_self" class="secondary-button relatedLinksCards__wrapper--secondaryBtn secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="Side effects" href="/side-effects/"><span aria-hidden="false">Side effects</span></a><br/></li></ul></div></div><div class="col-lg-4 col-md-4"><div class="relatedLinksCards__wrapper"><ul class="listtypenone"><li><a target="_self" class="secondary-button relatedLinksCards__wrapper--secondaryBtn secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="content_link_vd" aria-labelledby="Patient and caregiver resource library" href="/patient-and-caregiver-resources/"><span aria-hidden="false">Patient and caregiver resource library</span></a><br/></li></ul></div></div></div></div></div></section></div></main><section class="IndicationsAndSafety slideUp false"><div class="IndicationsAndSafety__wrapper global collapsed"><div class="cursor-pointer "><div class="IndicationsAndSafety__block firstContentHeading"><button class="IndicationsAndSafety__block__titleBlock" id="isi-expand-first-button" data-design-category="isi_ref_vd"><div class="row"><div class="col-lg-12 d-flex justify-content-between align-items-center"><p class="mb-0 IndicationsAndSafety__block__titleBlock__heroTitle">See Indications</p><i class="icons simple-icons blue-plus"></i></div></div></button></div><div class="IndicationsAndSafety__descBlock firstContent invisible d-none"><div class="row"><div class="col-lg-12"><p class="font-secondary spacer-14--y lh22">KEYTRUDA and KEYTRUDA QLEX are prescription medicines used to treat:</p><ul class="base-ul spacer-16--b"><li><span id="tray-expand-nonâsmall-cell-lung-cancer"><span>a kind of lung cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" href="/non-small-cell-lung-cancer/"> <!-- -->nonâsmall cell lung cancer (NSCLC)</a>.</span></span><ul><li>Each may be used in combination with chemotherapy that contains platinum and another chemotherapy medicine before surgery when you have early-stage NSCLC, which can be removed by surgery,<!-- --> <strong>and</strong> then continued alone after surgery to help prevent your lung cancer from coming back.<!-- --> </li><li>Each may be used with the chemotherapy medicines pemetrexed and a platinum as your first treatment when your lung cancer has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>)<!-- --> <strong>and</strong> is a type called â<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/combination-therapy-clinical-trial-results/">nonsquamous</a>â <strong>and</strong> your tumor does not have an abnormal âEGFRâ or âALKâ gene.</li><li>Each may be used with the chemotherapy medicines carboplatin and either paclitaxel or paclitaxel<!-- --> <span class="no-wrap">protein-bound</span> as your first treatment when your lung cancer has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>)<!-- --> <strong>and</strong> is a type called â<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/clinical-trial-results/">squamous</a>.â</li><li>Each may be used alone as your first treatment when your lung cancer has not spread outside your chest (stage III) and you cannot have surgery or chemotherapy with radiation, <strong>or</strong> your NSCLC has spread to other areas of your body<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>), <strong>and</strong> your tumor tests positive for<!-- --> <span class="no-line-break">âPDâL1â</span> <strong>and</strong> does not have an abnormal âEGFRâ or âALKâ gene.</li><li>Each may also be used alone for<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a> <!-- -->if you have tried chemotherapy that contains platinum and it did not work or is no longer working <strong>and</strong>, your tumor tests positive for âPD-L1â <strong>and</strong> if your tumor has an abnormal âEGFRâ or âALKâ gene, you have also received an âEGFRâ or âALKâ inhibitor medicine that did not work or is no longer working.</li><li>Each may be used as a treatment in adults for your lung cancer to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery and you have received platinum-based chemotherapy, <strong>and</strong> you have stage IB and your tumor(s) is 4 cm or greater in size, stage II, or stage IIIA NSCLC.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-melanoma"><span>
5a kind of skin cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="MEL" href="/melanoma/">melanoma</a>.</span></span><ul><li>Each may be used when your melanoma has spread or cannot be removed by surgery (advanced melanoma).</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective in children with advanced melanoma.</p></ul><ul><li>Each may be used in adults and children 12 years of age and older with stage IIB, stage IIC, or stage III melanoma, to help prevent melanoma from coming back after it and lymph nodes that contain cancer have been removed by surgery.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective in children younger than 12 years of age with melanoma.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-head-and-neck-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="HNSCC" href="/head-and-neck-cancer/">head and neck squamous cell cancer (HNSCC)</a>.</span></span><ul><li>Each may be used alone in adults with HNSCC before surgery when your cancer can be removed by surgery, has spread to nearby tissues, and your tumor tests positive for âPD-L1,â <strong>and</strong> then continued in combination with radiation with or without cisplatin after surgery, <strong>and</strong> then continued alone to help prevent your head and neck cancer from coming back.</li><li>Each may be used with the chemotherapy medicines fluorouracil and a platinum as your first treatment when your head and neck cancer has spread or returned and cannot be removed by surgery.</li><li>Each may be used alone as your first treatment when your head and neck cancer has spread or returned and cannot be removed by surgery, <strong>and</strong> your tumor tests positive for<!-- --> <span class="nowrap">âPDâL1.â</span></li><li>Each may be used alone when your head and neck cancer has spread or returned, <strong>and</strong> you have received chemotherapy that contains platinum and it did not work or is no longer working.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-urothelial-bladder-cancer"><span>a kind of bladder and urinary tract cancer called <a class="ContentLink--link" data-design-category="isi_ref_vd" href="/urothelial-bladder-cancer/">urothelial cancer</a>.</span></span><ul><li>Each may be used with the medicine enfortumab vedotin-ejfv in adults when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>).</li><li>Each may be used alone when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="UC" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>), <strong>and</strong> you are not able to receive chemotherapy that contains platinum (medicines called either cisplatin or carboplatin).</li><li>Each may be used alone when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="UC" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>), <strong>and</strong> you have received chemotherapy that contains platinum, and it did not work or is no longer working.</li><li>Each may be used with the medicine enfortumab vedotin-ejfv in adults before and after the surgical removal of your bladder when your bladder cancer has spread into the muscle layer of the bladder<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="MIBC" href="/muscle-invasive-bladder-cancer/">
5muscle invasive bladder cancer [MIBC]</a>) but not to other parts of the body.</li><li>Each may be used alone when your cancer has not spread to nearby tissue in the bladder, but is at high-risk for spreading (high-risk, non-muscle invasive bladder cancer [NMIBC]) and when your tumor is a type called âcarcinoma in situâ (CIS),<!-- --> <strong>and</strong> you have tried treatment with Bacillus Calmette-Guerin (BCG) and it did not work, <strong>and</strong> <!-- -->you are not able to or have decided not to have surgery to remove your bladder.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-msi-h-dmmr-colorectal-cancer"><span>a kind of cancer that is shown by a laboratory test to be a<!-- --> <!-- -->microsatellite instability-high<!-- --> <span class="no-line-break">(MSIâH)</span> <!-- -->or a mismatch repair deficient (dMMR) solid tumor. Each may be used in adults to treat:</span></span><ul><li>cancer that has spread or cannot be removed by surgery (advanced cancer), <strong>and</strong></li><li>has progressed following treatment, and you have no satisfactory treatment options.</li><p class="spacer-8--t">KEYTRUDA also may be used to treat children with this kind of cancer, and KEYTRUDA QLEX also may be used to treat children 12 years and older.</p><p class="spacer-8--t">It is not known if KEYTRUDA QLEX is safe and effective for this use in children younger than 12 years of age.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span>a kind of cancer called colon or rectal cancer. Each may be used when your cancer:</span><ul><li>has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="CRC" href="/msi-h-dmmr-colorectal-cancer/">advanced colon or rectal cancer</a>), <b>and</b></li><li>has been shown by a laboratory test to be microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-gastric-cancer"><span>a kind of stomach cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="GASTRIC" href="/gastric-cancer/">gastric or gastroesophageal junction (GEJ) adenocarcinoma</a>.</span></span><ul><li>Each may be used in adults in combination with fluoropyrimidine and platinum chemotherapy as your first treatment when your stomach cancer:<ul><li>is HER2-negative, <strong>and</strong> your tumor tests positive for âPD-L1,â <strong>and</strong></li><li>has spread or cannot be removed by surgery (advanced gastric cancer).</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-esophageal-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="ESO" href="/esophageal-cancer/">esophageal or certain gastroesophageal junction (GEJ) carcinomas</a> <!-- -->that cannot be cured by surgery or a combination of chemotherapy and radiation therapy.</span></span><ul><li>Each may be used in combination with platinum- and fluoropyrimidine-based chemotherapy medicines when your tumor tests positive for âPD-L1.â</li><li>Each may be used alone when:<ul><li>you have received one or more types of treatment, and it did not work or it is no longer working, <strong>and</strong></li><li>your tumor is a type called âsquamous,â <strong>and</strong></li><li>your tumor tests positive for â<span class="no-line-break">PD-L1</span>.â</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-cervical-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="CERVICAL" href="/cervical-cancer/">cervical cancer</a>.</span></span><ul><li>Each may be used with chemotherapy and radiation therapy when your cervical cancer has spread nearby to the lower part of your vagina or to pelvic organs or has affected your kidneys (Stage III to IVA FIGO 2014 classification).</li><li>Each may be used with chemotherapy medicines, with or without the medicine bevacizumab, when:<ul><li>your cervical cancer does not go away (persistent), has returned, or has spread (advanced cervical cancer),<!-- --> <b>and</b></li><li>your tumor tests positive for<!-- --> <span class="no-line-break">âPD-L1.â</span></li></ul></li><li>Each may be used alone when your cervical cancer:<ul><li>has returned, or has spread (advanced cervical cancer),<!-- --> <b>and</b></li><li>you have received chemotherapy, and it did not work or is no longer working, <b>and</b></li><li>your tumor tests positive for<!-- --> <span class="no-line-break">âPDâL1.â</span></li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-kidney-cancer"><span>
5a kind of kidney cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="RCC" href="/kidney-cancer/">renal cell carcinoma (RCC)</a>.</span></span><ul><li>Each may be used alone if you are at intermediate-high or high risk of your kidney cancer (RCC) coming back after surgery to:<ul><li>remove all or part of your kidney, <strong>or</strong></li><li>remove all or part of your kidney and also surgery to remove cancer that has spread to other parts of the body (metastatic lesions).</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-advanced-endometrial-cancer"><span>a kind of uterine cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="ENDO" href="/advanced-endometrial-cancer/">advanced endometrial carcinoma</a>.</span></span><ul><li>Each may be used with the chemotherapy medicines carboplatin and paclitaxel, and then may be used alone, in adults:<ul><li>when your cancer has spread (advanced), <strong>or</strong></li><li>if your cancer has returned.</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li>a kind of skin cancer called<!-- --> <!-- -->cutaneous squamous cell carcinoma (cSCC). Each may be used when your skin cancer has returned or spread,<!-- --> <b>and</b> cannot be cured by surgery or radiation.<ul><p class="spacer-8--t ">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-triple-negative-breast-cancer"><span>a kind of cancer called <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">triple-negative breast cancer (TNBC)</a>.</span></span><ul><li>Each may be used with chemotherapy medicines as treatment before surgery and then continued alone after surgery when you have early-stage breast cancer, <b>and</b> are at high risk of your breast cancer coming back<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">high-risk early-stage triple-negative breast cancer [TNBC]</a>).</li><li>Each may be used with the medicine sacituzumab govitecan-hziy in adults as your first treatment when your breast cancer cannot be removed by surgery, has spread to nearby tissues (locally advanced) or other parts of the body (metastatic), <strong>and</strong> tests positive for âPD-L1.â</li><li>Each may be used with chemotherapy medicines when your breast cancer has returned to nearby tissues and cannot be removed by surgery or has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">advanced TNBC</a>), <b>and</b> tests positive for âPD-L1.â</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="tray-expand-ovarian-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="OVARIAN" href="/ovarian-cancer/">ovarian cancer</a>.</span></span><ul><li>Each may be used in adults with the chemotherapy medicine paclitaxel, with or without the medicine bevacizumab, when your ovarian, fallopian tube, or primary peritoneal cancer:<ul><li>is resistant to chemotherapy that contains platinum, <strong>and</strong></li><li>tests positive for âPD-L1,â <strong>and</strong></li><li>you have received 1 or 2 types of treatment.</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><p><a class="ContentLink--link" data-design-category="isi_ref_vd" href="/keytruda-and-keytruda-qlex-faq/#what-are-pd1-and-pdl1">PD-L1</a> = programmed death ligand 1;</p><p>EGFR = epidermal growth factor receptor;</p><p>ALK = anaplastic lymphoma kinase;</p><p>FIGO = International Federation of Gynecology and Obstetrics;</p><p>HER2 = human epidermal growth factor receptor 2.</p></div></div></div></div><div class="cursor-pointer "><div class="IndicationsAndSafety__block lastContentHeading"><button class="IndicationsAndSafety__block__titleBlock" data-design-category="isi_ref_vd" id="expand-isi-safety"><div class="row"><div class="col-lg-12 d-flex justify-content-between align-items-center"><p class="IndicationsAndSafety__block__titleBlock__heroTitle mb-0">Important Safety Information</p><i class="icons simple-icons blue-plus"></i></div></div></button></div><div class="IndicationsAndSafety__descBlock lastContent secondDescBlock minimum-line collapsed"><div class="safety-information__content"><p class="spacer-16--b">Do not receive KEYTRUDA QLEX if you are allergic to berahyaluronidase, hyaluronidase or any of the inactive ingredients in KEYTRUDA QLEX.</p><p class="spacer-16--b">KEYTRUDA and KEYTRUDA QLEX are medicines that may treat certain cancers by working with your immune system. KEYTRUDA and KEYTRUDA QLEX can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen any time during treatment or even after your treatment has ended.</p><p class="spacer-16--b"><strong>Call or see your health care provider right away if you develop any signs or symptoms of the following problems or if they get worse. These are not all of the signs and symptoms of immune system problems that can happen with KEYTRUDA or KEYTRUDA QLEX:</strong></p><p class="spacer-16--b"><strong>Lung problems:</strong>
5 cough, shortness of breath, or chest pain.</p><p class="spacer-16--b"><strong>Intestinal problems:</strong> diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.</p><p class="spacer-16--b"><strong>Liver problems:</strong> yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); or bleeding or bruising more easily than normal.</p><p class="spacer-16--b"><strong>Hormone gland problems:</strong> headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness.</p><p class="spacer-16--b"><strong>Kidney problems:</strong> decrease in the amount of your urine; blood in your urine; swelling of your ankles; loss of appetite.</p><p class="spacer-16--b"><strong>Skin problems:</strong> rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes.</p><p class="spacer-16--b"><strong>Problems can also happen in other organs and tissues.</strong> Signs and symptoms of these problems may include: chest pain; irregular heartbeat; shortness of breath; swelling of ankles; confusion; sleepiness; memory problems; changes in mood or behavior; stiff neck; balance problems; tingling or numbness of the arms or legs; double vision; blurry vision; sensitivity to light; eye pain; changes in eyesight; persistent or severe muscle pain or weakness; muscle cramps; low red blood cells; bruising.</p><p class="spacer-16--b"><strong>Infusion, injection-related, and allergic reactions that can sometimes be severe or life-threatening.</strong> Signs and symptoms of infusion, injection-related, and allergic reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling like passing out, fever, and back pain.</p><p class="spacer-16--b"><strong>Rejection of a transplanted organ or tissue.</strong> Your health care provider should tell you what signs and symptoms you should report and they will monitor you, depending on the type of organ or tissue transplant that you have had.</p><p class="spacer-16--b"><strong>Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic).</strong> These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with KEYTRUDA or KEYTRUDA QLEX. Your health care provider will monitor you for these complications.</p><p class="spacer-16--b"><strong>Getting medical treatment right away may help keep these problems from becoming more serious.</strong> Your health care provider will check you for these problems during treatment with KEYTRUDA or KEYTRUDA QLEX. They may treat you with corticosteroid or hormone replacement medicines. They may also need to delay or completely stop treatment with KEYTRUDA and KEYTRUDA QLEX if you have severe side effects.</p><p class="spacer-16--b"><strong>Before you receive KEYTRUDA or KEYTRUDA QLEX, tell your health care provider if you</strong> have immune system problems such as Crohnâs disease, ulcerative colitis, or lupus; have had an organ or tissue transplant, including corneal transplant, or have had or plan to have a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic); have had radiation treatment in your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.</p><p class="spacer-16--b">If you are pregnant or plan to become pregnant, tell your health care provider. KEYTRUDA and KEYTRUDA QLEX can harm your unborn baby. If you are able to become pregnant, you will be given a pregnancy test before you start treatment. Use effective birth control during treatment with KEYTRUDA or KEYTRUDA QLEX and for 4 months after your last dose of KEYTRUDA or KEYTRUDA QLEX. Tell them right away if you think you may be pregnant or you become pregnant during treatment with KEYTRUDA or KEYTRUDA QLEX.</p><p class="spacer-16--b">Tell your health care provider if you are breastfeeding or plan to breastfeed. It is not known if KEYTRUDA or KEYTRUDA QLEX passes into your breast milk. Do not breastfeed during treatment with KEYTRUDA or KEYTRUDA QLEX and for 4 months after your last dose of KEYTRUDA or KEYTRUDA QLEX.</p><p class="spacer-16--b"><strong>Tell your health care provider about all the medicines you take,</strong> including prescription and over-the-counter medicines, vitamins, and herbal supplements.</p><p class="spacer-16--b">The most common side effects of KEYTRUDA QLEX when given with certain chemotherapy medicines include nausea; tiredness;
5 and muscle, bone, and joint pain.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when used alone, which may be experienced with KEYTRUDA QLEX, include feeling tired; pain, including pain in muscles; rash; diarrhea; fever; cough; decreased appetite; itching; shortness of breath; constipation; bones or joints and stomach-area (abdominal) pain; nausea; and low levels of thyroid hormone.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when used alone that are more common in children than adults, which may be experienced with KEYTRUDA QLEX, include fever, vomiting, headache, stomach area (abdominal) pain, and low levels of white blood cells and red blood cells (anemia).</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with certain chemotherapy or chemotherapy with radiation therapy medicines, which may be experienced with KEYTRUDA QLEX, include feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble breathing; fever; hair loss; inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight loss; stomach-area (abdominal) pain; joint and muscle pain; trouble sleeping; blisters or rash on the palms of your hands and soles of your feet; urinary tract infection; low levels of thyroid hormone; skin irritation in the radiation area; trouble swallowing; and dry mouth.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with enfortumab vedotin-ejfv, which may be experienced with KEYTRUDA QLEX, include rash; tingling or numbness of the arms or legs; feeling tired or weak; itching; diarrhea; hair loss; weight loss; decreased appetite; dry eye; nausea; constipation; changes in sense of taste; and urinary tract infection.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with chemotherapy and bevacizumab, which may be experienced with KEYTRUDA QLEX, include tingling or numbness of the arms or legs; hair loss; low red blood cell count; feeling tired or weak; nausea; low white blood cell count; diarrhea; high blood pressure; decreased platelet count; constipation; joint aches; vomiting; urinary tract infection; rash; low levels of thyroid hormone; decreased appetite; fever; mouth sores; and nosebleed.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with sacituzumab <span class="text-nowrap">govitecan-hziy,</span> which may be experienced with KEYTRUDA QLEX, include low red blood cell count, low white blood count, diarrhea, nausea, feeling tired or weak, hair loss, constipation, rash, vomiting, headache, and abdominal pain.</p><p class="spacer-16--b">These are not all the possible side effects of KEYTRUDA or KEYTRUDA QLEX. Talk to your health care provider for medical advice about side effects.</p><p class="spacer-16--b">You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a class="ContentLink--link" data-design-category="content_link_vd" href="/external-link/?continueUrl=https://www.fda.gov/Safety/MedWatch/default.htm">www.fda.gov/medwatch</a> or call <span class="call"><a class="ContentLink--link" data-design-category="content_link_vd" href="tel:800-332-1088">1-800-FDA-1088</a></span>.</p><p class="spacer-16--b"><strong>Please read the accompanying <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_mg.pdf">Medication Guide</a> for KEYTRUDA and discuss it with your doctor. The physician <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf">Prescribing Information</a> also is available.</strong></p><p class="spacer-16--b"><strong>Please read the accompanying <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda_qlex/keytruda_qlex_mg.pdf">
5Medication Guide</a> for KEYTRUDA QLEX and discuss it with your doctor. The physician <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda_qlex/keytruda_qlex_pi.pdf">Prescribing Information</a> also is available.</strong></p></div></div></div></div></section><div class="IndicationsAndSafety__expandssi "><div class="IndicationsAndSafety__expandssi__wrapper"><div class="d-flex justify-content-between align-item-center IndicationsAndSafety__expandssi__header"><button class="IndicationsAndSafety__block__titleBlock d-flex justify-content-between align-items-center" aria-label="Close indications panel"><p class="IndicationsAndSafety__block__titleBlock__heroTitle mb-0 d-block d-lg-none"></p><p class="IndicationsAndSafety__block__titleBlock__heroTitle mb-0 d-none d-lg-block"></p><i class="icons simple-icons blue-cancel d-block"></i></button></div><div></div></div></div><div class="layoutBox__wrapper globalIndication__wrapper spacer-64--b spacer-32__mob--b"><div class="container"><div class="row false" id="indication"><div class="col-lg-12"><section class="position-relative indication"><div class="indication-content"><div class="indication-heading"><h2 class="heading-h4 spacer-16--b" id="FDA-approved">FDA-Approved Indications for KEYTRUDA® (pembrolizumab) and KEYTRUDA QLEX⢠(pembrolizumab and berahyaluronidase alfa-pmph)</h2></div><div class="indication-list"><p class="font-secondary spacer-14--y lh22">KEYTRUDA and KEYTRUDA QLEX are prescription medicines used to treat:</p><ul class="base-ul spacer-16--b"><li><span id="expand-nonâsmall-cell-lung-cancer"><span>a kind of lung cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" href="/non-small-cell-lung-cancer/"> <!-- -->nonâsmall cell lung cancer (NSCLC)</a>.</span></span><ul><li>Each may be used in combination with chemotherapy that contains platinum and another chemotherapy medicine before surgery when you have early-stage NSCLC, which can be removed by surgery,<!-- --> <strong>and</strong> then continued alone after surgery to help prevent your lung cancer from coming back.<!-- --> </li><li>Each may be used with the chemotherapy medicines pemetrexed and a platinum as your first treatment when your lung cancer has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>)<!-- --> <strong>and</strong> is a type called â<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/combination-therapy-clinical-trial-results/">nonsquamous</a>â <strong>and</strong> your tumor does not have an abnormal âEGFRâ or âALKâ gene.</li><li>Each may be used with the chemotherapy medicines carboplatin and either paclitaxel or paclitaxel<!-- --> <span class="no-wrap">protein-bound</span> as your first treatment when your lung cancer has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>)<!-- --> <strong>and</strong> is a type called â<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/clinical-trial-results/">squamous</a>.â</li><li>Each may be used alone as your first treatment when your lung cancer has not spread outside your chest (stage III) and you cannot have surgery or chemotherapy with radiation, <strong>or</strong> your NSCLC has spread to other areas of your body<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a>), <strong>and</strong> your tumor tests positive for<!-- --> <span class="no-line-break">âPDâL1â</span> <strong>and</strong> does not have an abnormal âEGFRâ or âALKâ gene.</li><li>Each may also be used alone for<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="NSCLC" href="/non-small-cell-lung-cancer/">advanced NSCLC</a> <!-- -->if you have tried chemotherapy that contains platinum and it did not work or is no longer working <strong>and</strong>, your tumor tests positive for âPD-L1â <strong>and</strong> if your tumor has an abnormal âEGFRâ or âALKâ gene, you have also received an âEGFRâ or âALKâ inhibitor medicine that did not work or is no longer working.</li><li>Each may be used as a treatment in adults for your lung cancer to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery and you have received platinum-based chemotherapy, <strong>and</strong> you have stage IB and your tumor(s) is 4 cm or greater in size, stage II, or stage IIIA NSCLC.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-melanoma"><span>
5a kind of skin cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="MEL" href="/melanoma/">melanoma</a>.</span></span><ul><li>Each may be used when your melanoma has spread or cannot be removed by surgery (advanced melanoma).</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective in children with advanced melanoma.</p></ul><ul><li>Each may be used in adults and children 12 years of age and older with stage IIB, stage IIC, or stage III melanoma, to help prevent melanoma from coming back after it and lymph nodes that contain cancer have been removed by surgery.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective in children younger than 12 years of age with melanoma.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-head-and-neck-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="HNSCC" href="/head-and-neck-cancer/">head and neck squamous cell cancer (HNSCC)</a>.</span></span><ul><li>Each may be used alone in adults with HNSCC before surgery when your cancer can be removed by surgery, has spread to nearby tissues, and your tumor tests positive for âPD-L1,â <strong>and</strong> then continued in combination with radiation with or without cisplatin after surgery, <strong>and</strong> then continued alone to help prevent your head and neck cancer from coming back.</li><li>Each may be used with the chemotherapy medicines fluorouracil and a platinum as your first treatment when your head and neck cancer has spread or returned and cannot be removed by surgery.</li><li>Each may be used alone as your first treatment when your head and neck cancer has spread or returned and cannot be removed by surgery, <strong>and</strong> your tumor tests positive for<!-- --> <span class="nowrap">âPDâL1.â</span></li><li>Each may be used alone when your head and neck cancer has spread or returned, <strong>and</strong> you have received chemotherapy that contains platinum and it did not work or is no longer working.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-urothelial-bladder-cancer"><span>a kind of bladder and urinary tract cancer called <a class="ContentLink--link" data-design-category="isi_ref_vd" href="/urothelial-bladder-cancer/">urothelial cancer</a>.</span></span><ul><li>Each may be used with the medicine enfortumab vedotin-ejfv in adults when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>).</li><li>Each may be used alone when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="UC" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>), <strong>and</strong> you are not able to receive chemotherapy that contains platinum (medicines called either cisplatin or carboplatin).</li><li>Each may be used alone when your bladder or urinary tract cancer has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="UC" href="/advanced-urothelial-bladder-cancer/">locally advanced or metastatic urothelial cancer</a>), <strong>and</strong> you have received chemotherapy that contains platinum, and it did not work or is no longer working.</li><li>Each may be used with the medicine enfortumab vedotin-ejfv in adults before and after the surgical removal of your bladder when your bladder cancer has spread into the muscle layer of the bladder<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="MIBC" href="/muscle-invasive-bladder-cancer/">
5muscle invasive bladder cancer [MIBC]</a>) but not to other parts of the body.</li><li>Each may be used alone when your cancer has not spread to nearby tissue in the bladder, but is at high-risk for spreading (high-risk, non-muscle invasive bladder cancer [NMIBC]) and when your tumor is a type called âcarcinoma in situâ (CIS),<!-- --> <strong>and</strong> you have tried treatment with Bacillus Calmette-Guerin (BCG) and it did not work, <strong>and</strong> <!-- -->you are not able to or have decided not to have surgery to remove your bladder.</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-msi-h-dmmr-colorectal-cancer"><span>a kind of cancer that is shown by a laboratory test to be a<!-- --> <!-- -->microsatellite instability-high<!-- --> <span class="no-line-break">(MSIâH)</span> <!-- -->or a mismatch repair deficient (dMMR) solid tumor. Each may be used in adults to treat:</span></span><ul><li>cancer that has spread or cannot be removed by surgery (advanced cancer), <strong>and</strong></li><li>has progressed following treatment, and you have no satisfactory treatment options.</li><p class="spacer-8--t">KEYTRUDA also may be used to treat children with this kind of cancer, and KEYTRUDA QLEX also may be used to treat children 12 years and older.</p><p class="spacer-8--t">It is not known if KEYTRUDA QLEX is safe and effective for this use in children younger than 12 years of age.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span>a kind of cancer called colon or rectal cancer. Each may be used when your cancer:</span><ul><li>has spread or cannot be removed by surgery<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="CRC" href="/msi-h-dmmr-colorectal-cancer/">advanced colon or rectal cancer</a>), <b>and</b></li><li>has been shown by a laboratory test to be microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR).</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-gastric-cancer"><span>a kind of stomach cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="GASTRIC" href="/gastric-cancer/">gastric or gastroesophageal junction (GEJ) adenocarcinoma</a>.</span></span><ul><li>Each may be used in adults in combination with fluoropyrimidine and platinum chemotherapy as your first treatment when your stomach cancer:<ul><li>is HER2-negative, <strong>and</strong> your tumor tests positive for âPD-L1,â <strong>and</strong></li><li>has spread or cannot be removed by surgery (advanced gastric cancer).</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-esophageal-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="ESO" href="/esophageal-cancer/">esophageal or certain gastroesophageal junction (GEJ) carcinomas</a> <!-- -->that cannot be cured by surgery or a combination of chemotherapy and radiation therapy.</span></span><ul><li>Each may be used in combination with platinum- and fluoropyrimidine-based chemotherapy medicines when your tumor tests positive for âPD-L1.â</li><li>Each may be used alone when:<ul><li>you have received one or more types of treatment, and it did not work or it is no longer working, <strong>and</strong></li><li>your tumor is a type called âsquamous,â <strong>and</strong></li><li>your tumor tests positive for â<span class="no-line-break">PD-L1</span>.â</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-cervical-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="CERVICAL" href="/cervical-cancer/">cervical cancer</a>.</span></span><ul><li>Each may be used with chemotherapy and radiation therapy when your cervical cancer has spread nearby to the lower part of your vagina or to pelvic organs or has affected your kidneys (Stage III to IVA FIGO 2014 classification).</li><li>Each may be used with chemotherapy medicines, with or without the medicine bevacizumab, when:<ul><li>your cervical cancer does not go away (persistent), has returned, or has spread (advanced cervical cancer),<!-- --> <b>and</b></li><li>your tumor tests positive for<!-- --> <span class="no-line-break">âPD-L1.â</span></li></ul></li><li>Each may be used alone when your cervical cancer:<ul><li>has returned, or has spread (advanced cervical cancer),<!-- --> <b>and</b></li><li>you have received chemotherapy, and it did not work or is no longer working, <b>and</b></li><li>your tumor tests positive for<!-- --> <span class="no-line-break">âPDâL1.â</span></li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-kidney-cancer"><span>
5a kind of kidney cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="RCC" href="/kidney-cancer/">renal cell carcinoma (RCC)</a>.</span></span><ul><li>Each may be used alone if you are at intermediate-high or high risk of your kidney cancer (RCC) coming back after surgery to:<ul><li>remove all or part of your kidney, <strong>or</strong></li><li>remove all or part of your kidney and also surgery to remove cancer that has spread to other parts of the body (metastatic lesions).</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-advanced-endometrial-cancer"><span>a kind of uterine cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="ENDO" href="/advanced-endometrial-cancer/">advanced endometrial carcinoma</a>.</span></span><ul><li>Each may be used with the chemotherapy medicines carboplatin and paclitaxel, and then may be used alone, in adults:<ul><li>when your cancer has spread (advanced), <strong>or</strong></li><li>if your cancer has returned.</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li>a kind of skin cancer called<!-- --> <!-- -->cutaneous squamous cell carcinoma (cSCC). Each may be used when your skin cancer has returned or spread,<!-- --> <b>and</b> cannot be cured by surgery or radiation.<ul><p class="spacer-8--t ">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-triple-negative-breast-cancer"><span>a kind of cancer called <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">triple-negative breast cancer (TNBC)</a>.</span></span><ul><li>Each may be used with chemotherapy medicines as treatment before surgery and then continued alone after surgery when you have early-stage breast cancer, <b>and</b> are at high risk of your breast cancer coming back<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">high-risk early-stage triple-negative breast cancer [TNBC]</a>).</li><li>Each may be used with the medicine sacituzumab govitecan-hziy in adults as your first treatment when your breast cancer cannot be removed by surgery, has spread to nearby tissues (locally advanced) or other parts of the body (metastatic), <strong>and</strong> tests positive for âPD-L1.â</li><li>Each may be used with chemotherapy medicines when your breast cancer has returned to nearby tissues and cannot be removed by surgery or has spread<!-- --> <!-- -->(<a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="TNBC" href="/triple-negative-breast-cancer/">advanced TNBC</a>), <b>and</b> tests positive for âPD-L1.â</li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for these uses in children.</p></ul></li></ul><ul class="base-ul spacer-16--b"><li><span id="expand-ovarian-cancer"><span>a kind of cancer called<!-- --> <a class="ContentLink--link" data-design-category="isi_ref_vd" data-cancer-select-type="OVARIAN" href="/ovarian-cancer/">ovarian cancer</a>.</span></span><ul><li>Each may be used in adults with the chemotherapy medicine paclitaxel, with or without the medicine bevacizumab, when your ovarian, fallopian tube, or primary peritoneal cancer:<ul><li>is resistant to chemotherapy that contains platinum, <strong>and</strong></li><li>tests positive for âPD-L1,â <strong>and</strong></li><li>you have received 1 or 2 types of treatment.</li></ul></li><p class="spacer-8--t">It is not known if KEYTRUDA and KEYTRUDA QLEX are safe and effective for this use in children.</p></ul></li></ul><p><a class="ContentLink--link" data-design-category="isi_ref_vd" href="/keytruda-and-keytruda-qlex-faq/#what-are-pd1-and-pdl1">PD-L1</a> = programmed death ligand 1;</p><p>EGFR = epidermal growth factor receptor;</p><p>ALK = anaplastic lymphoma kinase;</p><p>FIGO = International Federation of Gynecology and Obstetrics;</p><p>HER2 = human epidermal growth factor receptor 2.</p><div id="isi"><h2 class="heading-h4 spacer-16--b spacer-32--t">Important Safety Information</h2><p class="spacer-16--b">Do not receive KEYTRUDA QLEX if you are allergic to berahyaluronidase, hyaluronidase or any of the inactive ingredients in KEYTRUDA QLEX.</p><p class="spacer-16--b">KEYTRUDA and KEYTRUDA QLEX are medicines that may treat certain cancers by working with your immune system. KEYTRUDA and KEYTRUDA QLEX can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen any time during treatment or even after your treatment has ended.</p><p class="spacer-16--b"><strong>Call or see your health care provider right away if you develop any signs or symptoms of the following problems or if they get worse. These are not all of the signs and symptoms of immune system problems that can happen with KEYTRUDA or KEYTRUDA QLEX:</strong></p><p class="spacer-16--b"><strong>Lung problems:</strong>
5 cough, shortness of breath, or chest pain.</p><p class="spacer-16--b"><strong>Intestinal problems:</strong> diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.</p><p class="spacer-16--b"><strong>Liver problems:</strong> yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); or bleeding or bruising more easily than normal.</p><p class="spacer-16--b"><strong>Hormone gland problems:</strong> headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness.</p><p class="spacer-16--b"><strong>Kidney problems:</strong> decrease in the amount of your urine; blood in your urine; swelling of your ankles; loss of appetite.</p><p class="spacer-16--b"><strong>Skin problems:</strong> rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; swollen lymph nodes.</p><p class="spacer-16--b"><strong>Problems can also happen in other organs and tissues.</strong> Signs and symptoms of these problems may include: chest pain; irregular heartbeat; shortness of breath; swelling of ankles; confusion; sleepiness; memory problems; changes in mood or behavior; stiff neck; balance problems; tingling or numbness of the arms or legs; double vision; blurry vision; sensitivity to light; eye pain; changes in eyesight; persistent or severe muscle pain or weakness; muscle cramps; low red blood cells; bruising.</p><p class="spacer-16--b"><strong>Infusion, injection-related, and allergic reactions that can sometimes be severe or life-threatening.</strong> Signs and symptoms of infusion, injection-related, and allergic reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling like passing out, fever, and back pain.</p><p class="spacer-16--b"><strong>Rejection of a transplanted organ or tissue.</strong> Your health care provider should tell you what signs and symptoms you should report and they will monitor you, depending on the type of organ or tissue transplant that you have had.</p><p class="spacer-16--b"><strong>Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic).</strong> These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with KEYTRUDA or KEYTRUDA QLEX. Your health care provider will monitor you for these complications.</p><p class="spacer-16--b"><strong>Getting medical treatment right away may help keep these problems from becoming more serious.</strong> Your health care provider will check you for these problems during treatment with KEYTRUDA or KEYTRUDA QLEX. They may treat you with corticosteroid or hormone replacement medicines. They may also need to delay or completely stop treatment with KEYTRUDA and KEYTRUDA QLEX if you have severe side effects.</p><p class="spacer-16--b"><strong>Before you receive KEYTRUDA or KEYTRUDA QLEX, tell your health care provider if you</strong> have immune system problems such as Crohnâs disease, ulcerative colitis, or lupus; have had an organ or tissue transplant, including corneal transplant, or have had or plan to have a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic); have had radiation treatment in your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.</p><p class="spacer-16--b">If you are pregnant or plan to become pregnant, tell your health care provider. KEYTRUDA and KEYTRUDA QLEX can harm your unborn baby. If you are able to become pregnant, you will be given a pregnancy test before you start treatment. Use effective birth control during treatment with KEYTRUDA or KEYTRUDA QLEX and for 4 months after your last dose of KEYTRUDA or KEYTRUDA QLEX. Tell them right away if you think you may be pregnant or you become pregnant during treatment with KEYTRUDA or KEYTRUDA QLEX.</p><p class="spacer-16--b">Tell your health care provider if you are breastfeeding or plan to breastfeed. It is not known if KEYTRUDA or KEYTRUDA QLEX passes into your breast milk. Do not breastfeed during treatment with KEYTRUDA or KEYTRUDA QLEX and for 4 months after your last dose of KEYTRUDA or KEYTRUDA QLEX.</p><p class="spacer-16--b"><strong>Tell your health care provider about all the medicines you take,</strong> including prescription and over-the-counter medicines, vitamins, and herbal supplements.</p><p class="spacer-16--b">The most common side effects of KEYTRUDA QLEX when given with certain chemotherapy medicines include nausea; tiredness;
5 and muscle, bone, and joint pain.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when used alone, which may be experienced with KEYTRUDA QLEX, include feeling tired; pain, including pain in muscles; rash; diarrhea; fever; cough; decreased appetite; itching; shortness of breath; constipation; bones or joints and stomach-area (abdominal) pain; nausea; and low levels of thyroid hormone.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when used alone that are more common in children than adults, which may be experienced with KEYTRUDA QLEX, include fever, vomiting, headache, stomach area (abdominal) pain, and low levels of white blood cells and red blood cells (anemia).</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with certain chemotherapy or chemotherapy with radiation therapy medicines, which may be experienced with KEYTRUDA QLEX, include feeling tired or weak; nausea; constipation; diarrhea; decreased appetite; rash; vomiting; cough; trouble breathing; fever; hair loss; inflammation of the nerves that may cause pain, weakness, and paralysis in the arms and legs; swelling of the lining of the mouth, nose, eyes, throat, intestines, or vagina; mouth sores; headache; weight loss; stomach-area (abdominal) pain; joint and muscle pain; trouble sleeping; blisters or rash on the palms of your hands and soles of your feet; urinary tract infection; low levels of thyroid hormone; skin irritation in the radiation area; trouble swallowing; and dry mouth.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with enfortumab vedotin-ejfv, which may be experienced with KEYTRUDA QLEX, include rash; tingling or numbness of the arms or legs; feeling tired or weak; itching; diarrhea; hair loss; weight loss; decreased appetite; dry eye; nausea; constipation; changes in sense of taste; and urinary tract infection.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with chemotherapy and bevacizumab, which may be experienced with KEYTRUDA QLEX, include tingling or numbness of the arms or legs; hair loss; low red blood cell count; feeling tired or weak; nausea; low white blood cell count; diarrhea; high blood pressure; decreased platelet count; constipation; joint aches; vomiting; urinary tract infection; rash; low levels of thyroid hormone; decreased appetite; fever; mouth sores; and nosebleed.</p><p class="spacer-16--b">The most common side effects observed with KEYTRUDA when given with sacituzumab <span class="text-nowrap">govitecan-hziy,</span> which may be experienced with KEYTRUDA QLEX, include low red blood cell count, low white blood count, diarrhea, nausea, feeling tired or weak, hair loss, constipation, rash, vomiting, headache, and abdominal pain.</p><p class="spacer-16--b">These are not all the possible side effects of KEYTRUDA or KEYTRUDA QLEX. Talk to your health care provider for medical advice about side effects.</p><p class="spacer-16--b">You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a class="ContentLink--link" data-design-category="content_link_vd" href="/external-link/?continueUrl=https://www.fda.gov/Safety/MedWatch/default.htm">www.fda.gov/medwatch</a> or call <span class="call"><a class="ContentLink--link" data-design-category="content_link_vd" href="tel:800-332-1088">1-800-FDA-1088</a></span>.</p><p class="spacer-16--b"><strong>Please read the accompanying <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_mg.pdf">Medication Guide</a> for KEYTRUDA and discuss it with your doctor. The physician <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf">Prescribing Information</a> also is available.</strong></p><p class="spacer-16--b"><strong>Please read the accompanying <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda_qlex/keytruda_qlex_mg.pdf">
5Medication Guide</a> for KEYTRUDA QLEX and discuss it with your doctor. The physician <a class="ContentLink--link" data-design-category="content_link_vd" target="_blank" href="https://www.merck.com/product/usa/pi_circulars/k/keytruda_qlex/keytruda_qlex_pi.pdf">Prescribing Information</a> also is available.</strong></p></div></div></div></section></div><div></div></div></div></div><footer class="footerContainer"><section class="globalFooter"><div class="container"><div class="globalFooter__wrapper"><div class="globalFooter__wrapper__logo-container d-flex"><div class="desktop-only"><a aria-label="Go to homepage" data-design-category="bottom_nav_vd" href="/"><svg width="180" height="57" viewBox="0 0 180 57" fill="none" xmlns="http://www.w3.org/2000/svg"><title>Homepage for Patient Site for KEYTRUDA® (pembrolizumab)</title><g clip-path="url(#clip0_357_2586)"><path d="M2.91174 34.1229C2.11991 37.5788 1.43702 41.106 1.43702 44.6793C1.43702 48.2527 2.01099 51.9267 2.91174 55.4077H1.83503C0.863049 52.0483 0.0293274 48.5924 0.0293274 45.0442C0.0293274 41.2989 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aria-hidden="true">Cost, insurance & financial help for KEYTRUDA QLEX</span><span id="sr-full-text" class="visually-hidden">Cost, insurance & financial help for KEYTRUDA Q-lecks</span></a></div><div class="globalFooter__wrapper__links-container--block"><h5 class="globalFooter__title">Indications & Safety</h5><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="bottom_nav_vd" aria-labelledby="Indications" href="#indication"><span aria-hidden="false">Indications</span></a><a target="_self" class="secondary-button secondary-button__iconRight secondary-button__iconRight secondary-button__iconRight" data-design-category="bottom_nav_vd" aria-labelledby="Important Safety Information" href="#isi"><span aria-hidden="false">Important Safety Information</span></a></div></div><div class="col-lg-4 col-md-6 col-12 ps-0 footer-tab"><div class="globalFooter__wrapper__links-container--block"><h5 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