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403              <article class="post-79941 post type-post status-publish format-standard has-post-thumbnail hentry category-news tag-cancer-epidemiology-research-program tag-cancer-outcomes tag-cancer-prevention-and-control-research-program tag-cancer-therapeutics-research-program tag-carrie-lee tag-clinical-research-program tag-daniel-reuland tag-home-feature tag-louise-henderson odd">
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406      <h1 class="entry-title">UNC Lineberger launches study to evaluate multi-cancer detection tests</h1>
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410        <p class="entry-meta__time"><time class="published" datetime="2026-08-11T12:00:58-04:00">August 11, 2026</time></p>
411        <p class="entry-meta__author byline author vcard">By <a href="https://unclineberger.org/author/ckalnen/" rel="author" class="fn">ckalnen</a></p>
412    </div>
413    <div class="social-sharing"><a href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Funclineberger.org%2Fnews%2Func-lineberger-launches-study-to-evaluate-multi-cancer-detection-tests%2F" class="social-sharing__link social-sharing__link--fb" target="_blank"><img src="https://unclineberger.org/wp-content/themes/heelium-white-coat/images/icons/blue/facebook.svg" alt="Facebook" width=32 height=32></a><a href="https://twitter.com/intent/tweet?text=UNC%20Lineberger%20launches%20study%20to%20evaluate%20multi-cancer%20detection%20tests&url=https%3A%2F%2Funclineberger.org%2Fnews%2Func-lineberger-launches-study-to-evaluate-multi-cancer-detection-tests%2F" class="social-sharing__link social-sharing__link--tw" target="_blank"><img src="https://unclineberger.org/wp-content/themes/heelium-white-coat/images/icons/blue/twitter.svg" alt="Twitter" width=32 height=32></a><a href="https://pinterest.com/pin/create/button/?url=https%3A%2F%2Funclineberger.org%2Fnews%2Func-lineberger-launches-study-to-evaluate-multi-cancer-detection-tests%2F&media=https%3A%2F%2Funclineberger.org%2Fwp-content%2Fuploads%2Fsites%2F867%2F2025%2F09%2Fblood-test-vial.jpg&description=UNC%20Lineberger%20launches%20study%20to%20evaluate%20multi-cancer%20detection%20tests" class="social-sharing__link social-sharing__link--pi" target="_blank"><img src="https://unclineberger.org/wp-content/themes/heelium-white-coat/images/icons/blue/pinterest.svg" alt="Pinterest" width=32 height=32></a><a href="https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Funclineberger.org%2Fnews%2Func-lineberger-launches-study-to-evaluate-multi-cancer-detection-tests%2F&title=UNC%20Lineberger%20launches%20study%20to%20evaluate%20multi-cancer%20detection%20tests" class="social-sharing__link social-sharing__link--li" target="_blank"><img src="https://unclineberger.org/wp-content/themes/heelium-white-coat/images/icons/blue/linkedin.svg" alt="LinkedIn" width=32 height=32></a><a href="mailto:?subject=UNC%20Lineberger%20launches%20study%20to%20evaluate%20multi-cancer%20detection%20tests&body=UNC%20Lineberger%20launches%20study%20to%20evaluate%20multi-cancer%20detection%20tests%0Ahttps%3A%2F%2Funclineberger.org%2Fnews%2Func-lineberger-launches-study-to-evaluate-multi-cancer-detection-tests%2F" class="social-sharing__link social-sharing__link--em" target="_blank"><img src="https://unclineberger.org/wp-content/themes/heelium-white-coat/images/icons/blue/email.svg" alt="Email" width=32 height=32></a></div></div>    </header>
414    <div class="entry-content">
415      <div class = "alert alert-info  oscitas-bootstrap-container"><strong>For more information about the Vanguard Study at UNC Lineberger, contact the UNC ACCESS Hub study team at <a href="mailto:[email protected]">[email protected]</a> or <a href="tel:919-843-4863">
415(919) 843-4863</a>.</div></strong></p>
416<p>UNC Lineberger Comprehensive Cancer Center is recruiting participants for the <a href="https://prevention.cancer.gov/research-areas/networks-consortia-programs/csrn/vanguard-study">Vanguard Study</a>, a national study of a new type of blood test that screens for several types of cancer. Researchers will evaluate whether these Multi-Cancer Detection (MCD) tests will help people ages 45 to 75 find cancer early when it may be easier to treat.</p>
417<figure id="attachment_71860" class="thumbnail wp-caption alignright" style="width: 510px"><img fetchpriority="high" decoding="async" class="wp-image-71860" src="https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated.jpg" alt="National Cancer Institute Cancer Screening Research Network." width="500" height="357" srcset="https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated.jpg 1345w, https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated-400x286.jpg 400w, https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated-1024x731.jpg 1024w, https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated-768x548.jpg 768w, https://unclineberger.org/wp-content/uploads/sites/867/2024/02/Reuland-Henderson-Lee-CSRN-feature-updated-600x428.jpg 600w" sizes="(max-width: 500px) 100v
417w, 500px" /><figcaption class="caption wp-caption-text">From left: Daniel Reuland, MD, MPH; Louise Henderson, PhD, MSPH; and Carrie Lee, MD, MPH.</figcaption></figure>
418<p>This is the first study of the <a href="https://www.fredhutch.org/en/research/institutes-networks-ircs/cancer-screening-research-network.html">Cancer Screening Research Network</a>, a new national network of primary care sites devoted to cancer screening research that is funded by the National Cancer Institute (NCI), part of the National Institutes of Health. UNC Lineberger is <a href="https://unclineberger.org/news/unc-lineberger-named-as-a-national-research-hub-for-nih-cancer-screening-study/">one of nine national CSRN research sites</a>, which will evaluate promising and emerging cancer screening technologies.</p>
419<p>“We’re excited to be part of this national study to understand how multi-cancer detection tests perform for people in our community,” said <a href="https://unclineberger.org/directory/daniel-s-reuland/">Daniel Reuland, MD, MPH</a>, professor of medicine at the UNC School of Medicine and co-director of UNC Lineberger’s <a href="https://unclineberger.org/ccsi">Carolina Cancer Screening Initiative</a>. “We need to know more about how these tests function in patient populations. This includes understanding both the potential upsides of detecting some cancers earlier as well as the potential downsides that can come from screening tests, which are inevitably imperfect.”</p>
420<p>Reuland, <a href="https://unclineberger.org/directory/louise-m-henderson/">Louise Henderson, PhD, MSPH</a>, professor of radiology at UNC School of Medicine and co-director of UNC Lineberger’s Carolina Cancer Screening Initiative, and <a href="https://unclineberger.org/directory/carrie-lee/">Carrie Lee, MD, MPH</a>, professor of medicine at UNC School of Medicine and medical director of <a href="https://unclineberger.org/clinical-trials">UNC Lineberger’s Clinical Trials Office</a>, will lead the UNC Lineberger ACCESS Hub.</p>
421<p>MCD tests detect biological substances released in the bloodstream by cancer cells. Each MCD test screens for several kinds of cancer, and the MCD tests in the Vanguard Study will screen for bladder, breast, colorectal, esophageal, stomach, liver, lung, ovarian, pancreatic and prostate cancer.</p>
422<h2>About the study</h2>
423<p>The Vanguard Study is recruiting adults ages 45 to 75 with no cancer diagnosis in the past five years. The study will evaluate two tests: Avantect® MCD Test by ClearNote Health, and the Shield<sup>TM</sup> MCD Test by Guardant Health.</p>
424<p><img decoding="async" class="alignright wp-image-86706" src="https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial.jpg" alt="Gloved hands carefully handling a blood sample in a medical laboratory environment." width="420" height="280" srcset="https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial.jpg 1280w, https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial-400x267.jpg 400w, https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial-1024x682.jpg 1024w, https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial-768x512.jpg 768w, https://unclineberger.org/wp-content/uploads/sites/867/2025/09/blood-test-vial-600x400.jpg 600w" sizes="(max-width: 420px) 100vw, 420px" />Study participants will give two blood samples and complete regular cancer screening as recommended by clinicians. Participants will be randomized to one of three arms: two MCD arms where their blood will be tested by an MCD test or a control arm where the blood will be stored for potential future research. By joining this study, participants will help shape the future of cancer screening.</p>
425<p>“We need to rigorously evaluate multi-cancer detection tests to understand if they’re effective and accurate cancer screening tools for everyone, and learn how participants navigate receiving their test results,” said Scott Ramsey, MD, PhD, principal investigator of the CSRN and cancer researcher at Fred Hutch Cancer Center.</p>
426<p>The Vanguard Study is an important preliminary step in the larger plan to evaluate how well MCD tests work for reducing cancer mortality. The Vanguard study will provide information on how MCD tests work as cancer screening tools and explore the decisions that patients and their doctors make based on their results.</p>
427<p><em>Editor&#8217;s note: this story was originally published September 9, 2025.</em></p>
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432    <span class="cat-links"><span class="screen-reader-text">Categories: </span><a href="https://unclineberger.org/category/news/" rel="category tag">News from Lineberger</a></span><br/>
433   <span class="tags-links"><span class="screen-reader-text">Tags: </span><a href="https://unclineberger.org/tag/cancer-epidemiology-research-program/" rel="tag">Cancer Epidemiology Research Program</a>, <a href="https://unclineberger.org/tag/cancer-outcomes/" rel="tag">Cancer Outcomes</a>, <a href="https://unclineberger.org/tag/cancer-prevention-and-control-research-program/" rel="tag">Cancer Prevention and Control Research Program</a>, <a href="https://unclineberger.org/tag/cancer-therapeutics-research-program/" rel="tag">Cancer Therapeutics Research Program</a>, <a href="https://unclineberger.org/tag/carrie-lee/" rel="tag">Carrie Lee</a>, <a href="https://unclineberger.org/tag/clinical-research-program/" rel="tag">
433Clinical Research Program</a>, <a href="https://unclineberger.org/tag/daniel-reuland/" rel="tag">Daniel Reuland</a>, <a href="https://unclineberger.org/tag/home-feature/" rel="tag">Home Feature</a>, <a href="https://unclineberger.org/tag/louise-henderson/" rel="tag">Louise Henderson</a></span></div>
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