https://hayes-lab.github.io/research/

1<!DOCTYPE html>
2<html>
3
4  <head>
5  
6  <link rel="apple-touch-icon" sizes="180x180" href="/apple-touch-icon.png">
7  <link rel="icon" type="image/png" sizes="32x32" href="/favicon-32x32.png">
8  <link rel="icon" type="image/png" sizes="16x16" href="/favicon-16x16.png">
9  <link rel="manifest" href="/site.webmanifest">
10  <link rel="mask-icon" href="/safari-pinned-tab.svg" color="#5bbad5">
11  <meta name="msapplication-TileColor" content="#da532c">
12  <meta name="theme-color" content="#ffffff">
13
14  <meta charset="utf-8">
15  <meta http-equiv="X-UA-Compatible" content="IE=edge">
16  <meta name="viewport" content="width=device-width, initial-scale=1">
17  <title>Hayes Lab - Research</title>
18  <meta name="description" content="Hayes Lab -- Research">
19  <link rel="stylesheet" href="/css/main.css">
20  <link rel="canonical" href="/research/">
21
22

23<script>

23
24  (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){
25  (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o),
26  m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m)
27  })(window,document,'script','https://www.google-analytics.com/analytics.js','ga');
28
29  ga('create', '

29UA-82472331-1

29', 'auto');
30  ga('send', 'pageview');
31

32</script>

32
33
34
35</head>
36
37
38  <body>
39
40    <div class="navbar navbar-default navbar-fixed-top" role="navigation">
41  <div class="container-fluid">
42	<div class="navbar-header">
43	  <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar-collapse-1" aria-expanded="false">
44		<span class="sr-only">Toggle navigation</span>
45		<span class="icon-bar"></span>
46		<span class="icon-bar"></span>
47		<span class="icon-bar"></span>
48	  </button>
49	
50    <a class="navbar-brand" href="/">Hayes Lab @ OUHC</a>
51	</div>
52	<div class="collapse navbar-collapse" id="navbar-collapse-1">
53	  <ul class="nav navbar-nav navbar-right">
54		<li><a href="/">Home</a></li>
55		<li><a href="/research">Research</a></li>
56		<li><a href="/projects">Links</a></li>
57		<li><a href="/team">Lab Members</a></li>
58		<li><a href="/publications">Publications</a></li>
59		<li><a href="/values">Philosophy</a></li>
60		<li><a href="/resources">Resources</a></li>
61		<li><a href="/vacancies">Join Us</a></li>
62	  </ul>
63	</div>
64  </div>
65</div>
66
67
68    <div class="container-fluid">
69      <div class="row">
70        <div id="textid" class="col-sm-12">
71  <h1 id="research-projects">Research Projects</h1>
72
73<p><img src="/images/respic/2021_Carloni.png" alt="" style="width: 50%; float: left; margin: 0px" /><br /><br /></p>
74
75<h4 id="imprinting-of-microglia-by-developmental-stressors">Imprinting of Microglia by Developmental Stressors</h4>
76<p>This project will explore the molecular mechanisms of how microglia “remember” early life stress exposures leading to an adaptation in their life-long response to future stimuli. We will evaluate mechanisms of innate immune memory including metabolic adaptations and epigenetic marks induced by maternal immune activation that persist across the lifespan of microglia from early development to aging.</p>
77
78<p><br /><br /></p>
79
80<p><br /><br /></p>
81
82<p><br /><br /></p>
83
84<p><img src="/images/respic/UMAP_MG.jpg" alt="" style="width: 20%; float: right; margin: 0px" /></p>
85
86<h4 id="microglia-heterogeneity-in-human-disease">Microglia heterogeneity in human disease</h4>
87<p>Microglia can polarize to many different immune activation states in both human and mouse models. We aim to determine which microglia states are prevalent in human neuroinflammatory disorders and can shape clinical pathology and disease risk.</p>
88
89<p><br /><br /></p>
90
91<p><br /><br /></p>
92
93<h4 id="microglia-mediated-regulation-of-striatal-circuit-development-and-activity">Microglia mediated regulation of striatal circuit development and activity</h4>
94<p>We showed microglia imprinted by maternal immune activation impaired the circuit actiivty of dopamine receptor type 2 medium spiny neurons in the ventral striatum. The project will evaluate how microglia shape the development and activity of this circuit.</p>
95
96<p><img src="/images/respic/Str.tif" alt="" style="width: 35%; float: center; margin: 0px" /></p>
97
98</div>
99
100      </div>
101    </div>
102
103    <div id="footer" class="panel">
104  <div class="panel-footer">
105	<div class="container-fluid">
106	  <div class="row">
107		<div class="col-sm-5">
108
109		  <p>&copy 2024 Hayes Lab. Site template from the  <a href="/aboutwebsite.html">Allan Lab</a></p>
110              <p>We are part of the <a href="https://basicsciences.ouhsc.edu/cb/">Department of Cell Biology</a> 
111              at the <a href="https://www.ouhsc.edu">University of Oklahoma Health Sciences Center</a></p>
112
113
114		   <p>  </p><p>
115
116		</div>
117		<div class="col-sm-6">
118		  Location:<br />
119      Department of Cell Biology<br />
120      University of Oklahoma Health Sciences Center<br />
121      940 Stanton L. Young Blvd, BMSB 103<br />
122      Oklahoma City, OK 73104<br />
123            (<a href="https://maps.app.goo.gl/EgJfoT5LSxLsPMG5A">Maps</a>)
124		</div>
125	  </div>
126	</div>
127  </div>
128</div>
129

130<script src="https://ajax.googleapis.com/ajax/libs/jquery/1.11.3/jquery.min.js"></script>

130

131<script src="/js/bootstrap.min.js"></script>

131
132
133
134  </body>
135
136</html>