1// Shared data for all direction renderers 2window.LAB_DATA = { 3 pi: { 4 name: "Kok Hao Chen", 5 credentials: "Ph.D.", 6 role: "Principal Scientist II", 7 affiliation: "Genome Institute of Singapore", 8 photo: "pi.jpg", 9 bio: "Pioneered MERFISH (Multiplexed Error-Robust FISH) during postdoctoral work at Harvard, enabling spatially resolved, highly multiplexed RNA profiling in single cells. The lab continues to develop new in situ omics technologies at GIS.", 10 orcid: "https://orcid.org/0000-0001-7406-7919", 11 scholar: "https://scholar.google.com/citations?user=H28iJakAAAAJ&hl=en", 12 email: ["chenkh", "a-star.edu.sg"], 13 }, 14 15 members: [ 16 { name: "Shijie Nigel Chou", credentials: "Ph.D.", role: "Senior Scientist I", photo: "person-nigel.jpg", initial: "NC" }, 17 { name: "Xinrui Zhou", credentials: "Ph.D.", role: "Senior Scientist I", photo: "person-xinrui.png", initial: "XZ" }, 18 { name: "Yen Ling Lee", credentials: "", role: "Lead Research Officer II", photo: "person-yenling.jpg", initial: "YL" }, 19 { name: "Jiao Cao", credentials: "Ph.D.", role: "Scientist", photo: "person-caojiao.jpg", initial: "JC" }, 20 { name: "Kaiyu Jin", credentials: "Ph.D.", role: "Joint Research Fellow (NUS)", photo: "", initial: "KJ" }, 21 { name: "Jose Guijarro Nuez", credentials: "", role: "A*STAR ARAP-MRC DTP PhD Student", photo: "person-jose.jpg",initial: "JG" }, 22 { name: "Matthew Kwok", credentials: "", role: "A*STARâUniversity of Warwick ARAP Joint PhD Student", photo: "", initial: "MK" }, 23 ], 24 25 alumni: [ 26 { name: "Wan Yi Seow", years: "2018â2025", current: "Senior Research Officer, Genome Institute of Singapore" }, 27 { name: "Dao Duc Tu", years: "2023â2025", current: "Lecturer, Posts and Telecommunications Institute of Technology" }, 28 { name: "Maurice Lee Youzong", years: "2020â2025", current: "Senior Scientist, Illumina" }, 29 { name: "Vipul Singhal", years: "2018â2024", current: "Head of Computational Biology, Integrated Biosciences" }, 30 { name: "Lurong Wang", years: "2022â2024", current: "Research Officer, Genome Institute of Singapore" }, 31 { name: "Jiamin Toh", years: "2019â2024", current: "Research Officer, Genome Institute of Singapore" }, 32 { name: "Norbert Ha", years: "2019â2024", current: "Biomedical Scientist, Delta Electronics" }, 33 { name: "Jack Petts-Lewis", years: "2021â2023", current: "Graduate Student, University of Warwick" }, 34 { name: "Lingfan Jiang", years: "2019â2023", current: "Research Scientist, KLA" }, 35 { name: "Jazlynn Tan", years: "2022", current: "University of Toronto" }, 36 { name: "Jeeranan Boonruangkan",years: "2018â2022", current: "Biofourmis" }, 37 { name: "Jolene Goh", years: "2016â2022", current: "Veranome Biosystems" }, 38 { name: "Mike Jin-An Huang", years: "2018â2021", current: "1910 Genetics" }, 39 { name: "Paul Cheng", years: "2018â2021", current: "Veranome Biosystems" }, 40 { name: "Kaviya Selva Raju", years: "2018â2020", current: "Research Associate, Applied Materials" }, 41 { name: "Siyi Chen", years: "2018", current: "Senior Scientist, Maiden Therapeutics" }, 42 { name: "Christabelle Goh", years: "2018", current: "Scientist II, Applied Materials" }, 43 { name: "Ziqing Winston Zhao", years: "2018â2019", current: "Assistant Professor, National University of Singapore" }, 44 { name: "Teck Por Lim", years: "2018â2019", current: "" }, 45 { name: "Mei Lun Chow", years: "2018", current: "Project Officer, Nanyang Technological University" }, 46 ], 47 48 publications: [ 49 { 50 year: 2026, journal: "Nature Communications", key: true, 51 title: "Spatial perturb-seq: single-cell functional genomics within intact tissue architecture", 52 authors: "Shen K., Seow W. Y., Keng C. T., Lim M. G. L., Lim D. S., Guo K., Meliani A., Hajis M. I. B., Wang B., Prabhakar S., Chen K. H., Chew W. L.", 53 doi: "https://doi.org/10.1038/s41467-026-69677-6", 54 tag: "Spatial perturb-seq", 55 }, 56 { 57 year: 2024, journal: "Nature Communications", key: true, thumb: "pub-fishnchips.png", 58 title: "Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes", 59 authors: "Zhou X.*, Seow W. Y.*, Ha N., Cheng T. H., Jiang L. F., Boonruangkan J., Goh J. J. L., Prabhakar S., Chou N.#, Chen K. H.#", 60 doi: "https://www.nature.com/articles/s41467-024-46669-y", 61 tag: "FISHnCHIPs", 62 }, 63 { 64 year: 2024, journal: "Nature Genetics", key: true, thumb: "pub-banksy.png", 65 title: "BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis", 66 authors: "Singhal V.*, Chou N.*, Lee J., Yue Y., Liu J., Chock W. K., Lin Li, Chang Y., Teo E., Lee H. K., Chen K. H.#, Prabhakar S.#", 67 doi: "https://www.nature.com/articles/s41588-024-01664-3", 68 tag: "BANKSY", 69 }, 70 { 71 year: 2020, journal: "Nature Methods", key: true, thumb: "pub-splitfish.png",
72 title: "Highly specific multiplexed RNA imaging in tissues with split-FISH", 73 authors: "Goh J. J. L.*, Chou N.*, Seow W. Y., Ha N., Cheng C. P. P., Chang Y., Zhao Z. W., Chen K. H.", 74 doi: "https://www.nature.com/articles/s41592-020-0858-0", 75 tag: "split-FISH", 76 }, 77 { 78 year: 2017, journal: "Nature Genetics", 79 title: "Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors", 80 authors: "Li H., Courtois E. T., Sengupta D., Tan Y., Chen K. H., Goh J. J. L., et al.", 81 doi: "https://www.nature.com/articles/ng.3818", 82 }, 83 { 84 year: 2016, journal: "PNAS", 85 title: "High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization", 86 authors: "Moffitt J. R.*, Hao J.*, Wang G.*, Chen K. H., Babcock H. P. & Zhuang X.", 87 doi: "https://www.pnas.org/doi/10.1073/pnas.1612826113", 88 }, 89 { 90 year: 2015, journal: "Science", key: true, thumb: "pub-merfish.png", 91 title: "Spatially resolved, highly multiplexed RNA profiling in single cells", 92 authors: "Chen K. H.*, Boettiger A. N.*, Moffitt J. R.*, Wang S. & Zhuang X.", 93 doi: "https://www.science.org/doi/10.1126/science.aaa6090", 94 tag: "MERFISH", 95 }, 96 { year: 2012, journal: "ACS Nano", 97 title: "Understanding oligonucleotide-templated nanocrystals: Growth mechanisms and surface properties", 98 authors: "Cha T. G., Baker B. A., Salgado J., Bates C. J., Chen K. H., Chang A. C., Han J. C., Strano M. S. & Choi J. H.", 99 doi: "https://pubs.acs.org/doi/10.1021/nn302779m" }, 100 { year: 2012, journal: "ChemPhysChem", 101 title: "Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection", 102 authors: "Bates M., Dempsey G. T., Chen K. H. & Zhuang X.", 103 doi: "https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cphc.201100735" }, 104 { year: 2011, journal: "Lab on a Chip", 105 title: "Wide-field single metal nanoparticle spectroscopy for high throughput localized surface plasmon resonance sensing", 106 authors: "Chen K. H., Hobley J., Foo Y. L. & Su X.", 107 doi: "https://pubs.rsc.org/en/content/articlelanding/2011/lc/c0lc00644k" }, 108 { year: 2011, journal: "Nature Methods", 109 title: "Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging", 110 authors: "Dempsey G. T.*, Vaughan J. C.*, Chen K. H.*, Bates M. & Zhuang X.", 111 doi: "https://www.nature.com/articles/nmeth.1768" }, 112 { year: 2010, journal: "Analytical Chemistry", 113 title: "Temperature-independent porous nanocontainers for single-molecule fluorescence studies", 114 authors: "Ishitsuka Y., Okumus B., Arslan S., Chen K. H. & Ha T.", 115 doi: "https://pubs.acs.org/doi/10.1021/ac101714u" }, 116 { year: 2007, journal: "J. Phys. Chem. A", 117 title: "Dispersion of single-walled carbon nanotubes with an extended diazapentacene derivative", 118 authors: "Mateo-Alonso A., Ehli C., Chen K. H., Guldi D. M. & Prato M.", 119 doi: "https://pubs.acs.org/doi/10.1021/jp0765648" }, 120 { year: 2006, journal: "JACS", 121 title: "Aptamer-capped nanocrystal quantum dots: a new method for label-free protein detection", 122 authors: "Choi J. H., Chen K. H. & Strano M. S.", 123 doi: "https://pubs.acs.org/doi/10.1021/ja066506k" }, 124 ], 125 126 research: [ 127 { tag: "MERFISH", title: "In situ transcriptomics", 128 desc: "We develop FISH-based methods â MERFISH, split-FISH, FISHnCHIPs â that image hundreds to thousands of RNA species simultaneously inside intact tissue, without dissociation." }, 129 { tag: "Spatial omics", title: "Spatial omics technology", 130 desc: "Our platforms capture gene expression, cell identity, and tissue architecture in the same measurement, producing a molecular cartography of living systems." }, 131 { tag: "BANKSY", title: "Computational analysis", 132 desc: "We build open-source tools â including BANKSY â to extract biological insight from complex, high-dimensional spatial datasets at scale." }, 133 { tag: "Biology", title: "Systems biology", 134 desc: "We integrate spatial measurements with systems-level modeling to understand how gene regulatory networks operate in tissue context, and how they break in disease." }, 135 ], 136 137 news: [ 138 { date: "Jan 2026", title: "Welcoming Matthew to the lab", 139 note: "Matthew Kwok joins us as an A*STARâUniversity of Warwick ARAP Joint PhD student." }, 140 { date: "Mar 2024", title: "FISHnCHIPs published in Nature Communications", 141 note: "A new method for highly sensitive spatial transcriptomics using co-expressed gene sets." }, 142 { date: "Apr 2024", title: "Welcoming Cao Jiao to the lab",
143 note: "Cao Jiao joins us as a Scientist." }, 144 { date: "Feb 2024", title: "BANKSY out in Nature Genetics", 145 note: "A unified framework for cell typing and tissue domain segmentation." }, 146 { date: "Sep 2024", title: "Welcoming Jose to the lab", 147 note: "Jose joins us as an A*STAR ARAP-MRC DTP PhD scholar." }, 148 { date: "Ongoing", title: "Positions available", 149 note: "We are hiring post-doctoral fellows and research officers. Get in touch." }, 150 ], 151 152 software: [ 153 { name: "split-fish", desc: "Multiplexed FISH image analysis pipeline used to analyze split-FISH data.", 154 lang: "Python", paper: "Nature Methods, 2020", 155 repo: "https://github.com/KHChenLab/split-fish", 156 paperUrl: "https://www.nature.com/articles/s41592-020-0858-0" }, 157 { name: "FISHnCHIPs", desc: "Software for FISHnCHIPs â highly sensitive spatial transcriptomics using co-expressed gene sets.", 158 lang: "Jupyter Notebook", paper: "Nature Communications, 2024", 159 repo: "https://github.com/KHChenLab/FISHnCHIPs", 160 paperUrl: "https://www.nature.com/articles/s41467-024-46669-y" }, 161 { name: "BANKSY", desc: "Unified framework for cell typing and tissue domain segmentation in spatial omics.", 162 lang: "R / Python", paper: "Nature Genetics, 2024", 163 repo: "https://github.com/prabhakarlab/Banksy", 164 paperUrl: "https://www.nature.com/articles/s41588-024-01664-3" }, 165 ], 166 167 gallery: [ 168 { src: "gallery-2026-02.jpg", date: "Feb 2026", caption: "Lo hei lunch" }, 169 { src: "gallery-2025-12.jpg", date: "Dec 2025", caption: "Christmas potluck" }, 170 { src: "gallery-2024-09.png", date: "Sep 2024", caption: "Lab outing" }, 171 { src: "gallery-2024-08.png", date: "Aug 2024", caption: "Group photo" }, 172 { src: "gallery-2023-07.png", date: "Jul 2023", caption: "Lab gathering" }, 173 { src: "gallery-2023-04.jpg", date: "Apr 2023", caption: "Windsor Nature Park" }, 174 { src: "gallery-2023-02.jpg", date: "Feb 2023", caption: "Hot pot night" }, 175 { src: "gallery-2022-11.png", date: "Nov 2022", caption: "Lab outing" }, 176 { src: "gallery-2022-04.jpg", date: "Apr 2022", caption: "Rail corridor walk" }, 177 { src: "gallery-2019-12.jpg", date: "Dec 2019", caption: "Year-end dinner" }, 178 { src: "gallery-2018-11.png", date: "Nov 2018", caption: "Halloween" }, 179 { src: "gallery-2018-10.jpg", date: "Oct 2018", caption: "Pizza lunch" }, 180 ], 181};
Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.