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26 27 28</head> 29 30 31 <body> 32 33 <div class="navbar navbar-default navbar-fixed-top" role="navigation"> 34 <div class="container-fluid"> 35 <div class="navbar-header"> 36 <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar-collapse-1" aria-expanded="false"> 37 <span class="sr-only">Toggle navigation</span> 38 <span class="icon-bar"></span> 39 <span class="icon-bar"></span> 40 <span class="icon-bar"></span> 41 </button> 42 43 <a class="navbar-brand" href="/">Sanders Lab @ UCSF</a> 44 </div> 45 46 <div class="collapse navbar-collapse" id="navbar-collapse-1"> 47 <ul class="nav navbar-nav navbar-right"> 48 <li><a href="/">Home</a></li> 49 <li><a href="/team">Team</a></li> 50 <li><a href="/research">Research</a></li> 51 <li><a href="/publications">Publications</a></li> 52 <li><a href="/code">Code</a></li> 53 <li><a href="/data">Data</a></li> 54 <li><a href="/contact">Contact</a></li> 55 </ul> 56 </div> 57 58 </div> 59</div> 60 61 62 <div class="container-fluid"> 63 <div class="row"> 64 <div id="homeid" class="col-sm-8"> 65 <!-- <h1>Welcome to the Allan Lab</h1> --> 66 67 <h1 id="welcome-to-sanders-lab-at-ucsf">Welcome to Sanders Lab at UCSF</h1> 68 69<p><img src="/images/Lab_Logo_v6c.png" alt="" style="width: 170px; float: left;margin-right: 20px; border: 10px" /></p> 70 71<p>The Sanders Lab aims to identify the etiology of developmental disorders through the discovery of genetic risk factors. Over the past few years there has been rapid progress in identifying the genes that play a role in autism spectrum disorder (ASD). We aim to continue this progress, leverage these findings to build a more complete understanding of ASD, and to extend this approach to other human disorders, including congenital malformations.</p> 72 73<p>There are five main areas of research:</p> 74 75<ol> 76 <li><strong>Gene discovery</strong>: Genomic analysis of DNA using high-throughput sequencing to identify genes associated with human disorders</li> 77 <li><strong>Understanding the noncoding genome</strong>: Using whole-genome sequencing to identify the elements of the noncoding genome that contribute to ASD</li> 78 <li><strong>The role of SCN2A in human disorders</strong>: SCN2A mutations are one of the most common causes of ASD; we aim to understand how this risk is mediated with the view to developing therapeutics</li> 79 <li><strong>Understanding neurodevelopment</strong>: Leveraging functional genomic data to understand physiological brain development and the pathology associated with neuropsychiatric disorders</li> 80 <li><strong>Sex bias in ASD</strong>: Identifying genes and gene networks that lead to the preponderance of males diagnosed with ASD</li> 81</ol> 82 83<h3 id="technologies-and-methods">Technologies and methods</h3> 84<p>The Sanders Lab is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including: whole-exome sequencing, whole-genome sequencing, de novo mutation detection, RNA-Seq, and ChIP-Seq.</p> 85 86<h3 id="collaborators">Collaborators</h3> 87<p>We work with closely with numerous collaborators, including the <a href="https://www.mstatelab.com/">State Lab</a> and <a href="https://benderlab.ucsf.edu/lab-members">Bender Lab</a> at UCSF, the <a href="https://www.psychiatry.pitt.edu/about-us/our-people/faculty/bernie-j-devlin-phd">Devlin Lab</a> at UPMC, the <a href="http://www.stat.cmu.edu/~roeder/">Roeder Lab</a> at Carnegie Mellon, the <a href="http://medicine.yale.edu/lab/sestan/index.aspx">Sestan Lab</a>, and the <a href="http://talkowski.mgh.harvard.edu/">Talkowski lab</a> at Harvard.</p> 88 89<h3 id="joining-sanders-lab">Joining Sanders Lab</h3> 90<p>If you are interested in joining please go to the <a href="recruitment">recruitment</a> page.</p> 91 92<h3 id="funding">Funding</h3> 93<p>We are grateful for funding from the <a href="https://www.nimh.nih.gov/">National Institute of Mental Health</a> and the <a href="https://www.sfari.org/">The Simons Foundation Autism Research Initiative</a>, the <a href="https://autismsciencefoundation.org/">Autism Science Foundation</a>, and the <a href="https://www.bbrfoundation.org/">Brain & Behavior Research Foundation</a>.</p> 94 95<figure class="third"> 96 <p><img src="/images/logopic/Logo_NIMH.png" style="width: 200px" /> <img src="/images/logopic/Logo_SFARI.png" style="width: 200px" /></p> 97 98 <p><img src="/images/logopic/Logo_ASF.jpeg" style="width: 200px" /> <img src="/images/logopic/Logo_BBRF.png" style="width: 200px" /></p> 99</figure> 100 101 102 </div> 103 <div id="newsid" class="col-sm-4" > 104 105<div class="well"> 106<h4>News</h4> 107 108 109Aug 13, 2021 110<p><em>Welcome to <a href='team/nickpage'>Nick Page</a>, a graduate student who has joined the Sanders and Ahituv labs!</em></p> 111 112Feb 11 2021 113<p><em>New paper! <a href='https://elifesciences.org/articles/61408'>Young et al. 2021</a> published in eLife on 3D atlas construction, applied to the Allen Developing Mouse Brain Atlas.</em></p> 114 115Sept 27 2020 116<p><em>New paper! <a href='https://currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1002/cpns.104'>Young et al. 2020</a> published in Current Protocols in Neuroscience on using <a href='https://github.com/sanderslab/magellanmapper'>MagellanMapper</a> for image analysis.</em></p> 117 118Dec 13th 2018 119<p><em>New paper! <a href='http://science.sciencemag.org/content/362/6420/eaat6576.long'> An et al. 2018 </a> published in Science, highlights the role of promoters in autism.</em></p> 120 121Dec 1st 2018 122<p><em>Our work with the Autism Sequencing Consortium identifies 99 autism genes, paper submitted to <a href='https://www.bi
122orxiv.org/content/early/2018/12/01/484113'> BioRxiv </a>.</em></p> 123 124May 29th 2018 125<p><em>Donna presents the labâs recent work, <a href='https://youtu.be/zR608Q20jn8'>'Analytical Framework for WGS and its Implications for ASD'</a> at the PGC Statistical Genetics Group online meeting.</em></p> 126 127May 9th 2018 128<p><em>Stephan, Donna, Brooke and Joon travel to Rotterdam, Netherlands, to share our latest work at <a href='https://insar.confex.com/insar/2018/webprogram/start.html'>INSAR 2018</a>.</em></p> 129 130May 7th 2018 131<p><em>Donna and Joonâs latest works highlighted in <a href='https://autismsciencefoundation.org/news/wild-new-genetic-hot-spots/'>Autism Science Foundation Podcast</a>.</em></p> 132 133April 27th 2018 134<p><em>New paper! <a href='https://www.nature.com/articles/s41588-018-0107-y'> Werling et al. 2018 </a> published in Nature Genetics in collaboration with the Autism Sequencing Consortium.</em></p> 135 136 137<h4><a href="/allnews.html">... see all News</a></h4> 138 139 </div> 140 </div> 141 142 </div> 143 </div> 144 145 <div id="footer" class="panel"> 146 <div class="panel-footer"> 147 <div class="container-fluid"> 148 <div class="row"> 149 150 151 <ul class="nav navbar-nav navbar-right"> 152 <li><a href="https://psych.ucsf.edu/">Department of Psychiatry</a></li> 153 <li><a href="https://www.ucsf.edu/">UCSF</a></li> 154 <li><a href="/about">About</a></li> 155 <li><a href="/recruitment">Recruitment</a></li> 156 </ul> 157 158 159 </div> 160 </div> 161 </div> 162</div> 163
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