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4<aside class=search-results id=search><div class=container><section class=search-header><div class="row no-gutters justify-content-between mb-3"><div class=col-6><h1>Search</h1></div><div class="col-6 col-search-close"><a class=js-search href=#><i class="fas fa-times-circle text-muted" aria-hidden=true></i></a></div></div><div id=search-box><input name=q id=search-query placeholder=Search... autocapitalize=off autocomplete=off autocorrect=off spellcheck=false type=search class=form-control></div></section><section class=section-search-results><div id=search-hits></div></section></div></aside><div class=page-header><nav class="navbar navbar-expand-lg navbar-light compensate-for-scrollbar" id=navbar-main><div class=container><div class="d-none d-lg-inline-flex"><a class=navbar-brand href=/>John L. Daristotle</a></div><button type=button class=navbar-toggler data-toggle=collapse data-target=#navbar-content aria-controls=navbar aria-expanded=false aria-label="Toggle navigation">
5<span><i class="fas fa-bars"></i></span></button><div class="navbar-brand-mobile-wrapper d-inline-flex d-lg-none"><a class=navbar-brand href=/>John L. Daristotle</a></div><div class="navbar-collapse main-menu-item collapse justify-content-start" id=navbar-content><ul class="navbar-nav d-md-inline-flex"><li class=nav-item><a class=nav-link href=/#about data-target=#about><span>Home</span></a></li><li class=nav-item><a class=nav-link href=/#publications data-target=#publications><span>Publications</span></a></li><li class=nav-item><a class=nav-link href=/#talks data-target=#talks><span>Talks</span></a></li><li class=nav-item><a class=nav-link href=/#contact data-target=#contact><span>Contact</span></a></li></ul></div><ul class="nav-icons navbar-nav flex-row ml-auto d-flex pl-md-2"><li class=nav-item><a class="nav-link js-search" href=# aria-label=Search><i class="fas fa-search" aria-hidden=true></i></a></li><li class="nav-item dropdown theme-dropdown"><a href=# class=nav-link data-toggle=dropdown aria-haspopup=true aria-label="Display preferences"><i class="fas fa-moon" aria-hidden=true></i></a><div class=dropdown-menu><a href=# class="dropdown-item js-set-theme-light"><span>Light</span></a>
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7<a href=# class="dropdown-item js-set-theme-auto"><span>Automatic</span></a></div></li></ul></div></nav></div><div class=page-body><span class="js-widget-page d-none"></span><section id=about class="home-section wg-about"><div class=home-section-bg></div><div class=container><div class=row><div class="col-12 col-lg-4"><div id=profile><img class="avatar avatar-circle" src=/author/john-l.-daristotle/avatar_hud57950e77d39220dbb13595541319b6b_197207_270x270_fill_q75_lanczos_center.jpg alt="John L. Daristotle"><div class=portrait-title><h2>John L. Daristotle</h2><h3>Postdoctoral Associate</h3><h3><a href=http://jaklenecgroup.mit.edu/ target=_blank rel=noopener><span>Jaklenec Group + Langer Lab, Koch Institute for Integrative Cancer Research at MIT</span></a></h3></div><ul class=network-icon aria-hidden=true><li><a href=/#contact aria-label=envelope><i class="fas fa-envelope big-icon"></i></a></li><li><a href="https://scholar.google.com/citations?user=im4igz8AAAAJ&hl=en" target=_blank rel=noopener aria-label=graduation-cap><i class="fas fa-graduation-cap big-icon"></i></a></li><li><a href=https://www.researchgate.net/profile/John_Daristotle target=_blank rel=noopener aria-label=linkedin><i class="fab fa-linkedin big-icon"></i></a></li></ul></div></div><div class="col-12 col-lg-8"><h1>Biography</h1><p>I am a postdoctoral researcher in the Jaklenec Group at the Langer Lab. My research projects include:</p><ul><li>engineering biodegradable polymers for vaccine delivery</li><li>polymer processing for biomedical applications</li><li>drug delivery systems for nucleic acid-based therapeutics</li><li>immunomodulatory biomaterials</li></ul><div class=row><div class=col-md-5><h3>Interests</h3><ul class=ul-interests><li>drug delivery</li><li>polymer processing</li><li>immunoengineering</li><li>surgical materials</li></ul></div><div class=col-md-7><h3>Education</h3><ul class="ul-edu fa-ul"><li><i class="fa-li fas fa-graduation-cap"></i><div class=description><p class=course>PhD in Bioengineering, 2019</p><p class=institution>University of Maryland</p></div></li><li><i class="fa-li fas fa-graduation-cap"></i><div class=description><p class=course>BS in Chemical and Biomolecular Engineering, 2014</p><p class=institution>University of Maryland</p></div></li></ul></div></div></div></div></div></section><section id=experience class="home-section wg-experience"><div class=home-section-bg></div><div class=container><div class=row><div class="col-12 col-lg-4 section-heading"><h1>Experience</h1></div><div class="col-12 col-lg-8"><div class="row experience"><div class="col-auto text-center flex-column d-none d-sm-flex"><div class="row h-50"><div class=col>&nbsp;</div><div class=col>&nbsp;</div></div><div class=m-2><span class="badge badge-pill border exp-fill">&nbsp;</span></div><div class="row h-50"><div class="col border-right">&nbsp;</div><div class=col>&nbsp;</div></div></div><div class="col py-2"><div class=card><div class=card-body><h4 class="card-title exp-title text-muted mt-0 mb-1">Postdoctoral Associate</h4><h4 class="card-title exp-company text-muted my-0"><a href=http://jaklenecgroup.mit.edu/ target=_blank rel=noopener>Jaklenec Group + Langer Lab, Koch Institute for Integrative Cancer Research at MIT</a></h4><div class="text-muted exp-meta">Jan 2020 –
8Present
9<span class=middot-divider></span><span>Cambridge, MA</span></div><div class=card-text>Engineering drug delivery systems for vaccines using microfabricated polymers</div></div></div></div></div><div class="row experience"><div class="col-auto text-center flex-column d-none d-sm-flex"><div class="row h-50"><div class="col border-right">&nbsp;</div><div class=col>&nbsp;</div></div><div class=m-2><span class="badge badge-pill border">&nbsp;</span></div><div class="row h-50"><div class=col>&nbsp;</div><div class=col>&nbsp;</div></div></div><div class="col py-2"><div class=card><div class=card-body><h4 class="card-title exp-title text-muted mt-0 mb-1">Graduate Research Assistant</h4><h4 class="card-title exp-company text-muted my-0"><a href=http://fml.umd.edu target=_blank rel=noopener>Functional Macromolecular Lab @ University of Maryland, College Park</a></h4><div class="text-muted exp-meta">Aug 2014 –
10Jan 2020
11<span class=middot-divider></span><span>College Park, MD</span></div><div class=card-text>
11Sprayable, biodegradable polymer blends for tissue adhesion</div></div></div></div></div></div></div></div></section><section id=publications class="home-section wg-pages"><div class=home-section-bg></div><div class=container><div class=row><div class="col-12 col-lg-4 section-heading"><h1>Recent Publications</h1></div><div class="col-12 col-lg-8"><div class="alert alert-note"><div>Quickly discover relevant content by <a href=./publication/>filtering publications</a>.</div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/publication/barda/>A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines</a></h3><a href=/publication/barda/ class=summary-link><div class=article-style>Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP) format could enhance vaccine access in …</div></a><div class="stream-meta article-metadata"><div><span><a href=/author/aurelien-vander-straeten/>Aurélien vander Straeten</a></span>, <span><a href=/author/morteza-sarmadi/>Morteza Sarmadi</a></span>, <span><a href=/author/john-l.-daristotle/>John L. Daristotle</a></span>, <span><a href=/author/maria-kanelli/>Maria Kanelli</a></span>, <span><a href=/author/lisa-h.-tostanoski/>Lisa H. Tostanoski</a></span>, <span><a href=/author/joe-collins/>Joe Collins</a></span>, <span><a href=/author/apurva-pardeshi/>Apurva Pardeshi</a></span>, <span><a href=/author/jooli-han/>Jooli Han</a></span>, <span><a href=/author/dhruv-varshney/>Dhruv Varshney</a></span>, <span><a href=/author/behnaz-eshaghi/>Behnaz Eshaghi</a></span>, <span><a href=/author/johnny-garcia/>Johnny Garcia</a></span>, <span><a href=/author/timothy-a.-forster/>Timothy A. Forster</a></span>, <span><a href=/author/gary-li/>Gary Li</a></span>, <span><a href=/author/nandita-menon/>Nandita Menon</a></span>, <span><a href=/author/sydney-l.-pyon/>Sydney L. Pyon</a></span>, <span><a href=/author/linzixuan-zhang/>Linzixuan Zhang</a></span>, <span><a href=/author/catherine-jacob-dolan/>Catherine Jacob-Dolan</a></span>, <span><a href=/author/olivia-c.-powers/>Olivia C. Powers</a></span>, <span><a href=/author/kevin-hall/>Kevin Hall</a></span>, <span><a href=/author/shahad-k.-alsaiari/>Shahad K. Alsaiari</a></span>, <span><a href=/author/morris-wolf/>Morris Wolf</a></span>, <span><a href=/author/mark-w.-tibbitt/>Mark W. Tibbitt</a></span>, <span><a href=/author/robert-farra/>Robert Farra</a></span>, <span><a href=/author/dan-h.-barouch/>Dan H. Barouch</a></span>, <span><a href=/author/robert-langer/>Robert Langer</a></span>, <span><a href=/author/ana-jaklenec/>Ana Jaklenec</a></span></div></div><div class=btn-links><a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1038/s41587-023-01774-z target=_blank rel=noopener>PDF</a>
12<button type=button class="btn btn-outline-primary my-1 mr-1 btn-sm js-cite-modal" data-filename=/publication/barda/cite.bib>
13Cite</button>
14<a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1038/s41587-023-01774-z target=_blank rel=noopener>DOI</a></div></div><div class=ml-3><a href=/publication/barda/><img src=/publication/barda/featured_hu20d7697e30cab3eaa2285680b6029acb_92951_ad137b170b38de25f6843ac681d3e2a9.jpg data-src=/publication/barda/featured_hu20d7697e30cab3eaa2285680b6029acb_92951_150x0_resize_q75_lanczos.jpg alt="A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines" class=lazyload></a></div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/publication/vita/>Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification</a></h3><a href=/publication/vita/ class=summary-link><div class=article-style>Food fortification is an effective strategy to address vitamin A (VitA) deficiency, which is the leading cause of childhood blindness …</div></a><div class="stream-meta article-metadata"><div><span><a href=/author/wen-tang/>Wen Tang</a></span>, <span><a href=/author/jia-zhuang/>Jia Zhuang</a></span>, <span><a href=/author/aaron-c.-anselmo/>Aaron C. Anselmo</a></span>, <span><a href=/author/xian-xu/>Xian Xu</a></span>, <span><a href=/author/aranda-duan/>Aranda Duan</a></span>, <span><a href=/author/ruojie-zhang/>Ruojie Zhang</a></span>, <span><a href=/author/james-l.-sugarman/>James L. Sugarman</a></span>, <span><a href=/author/yingying-zeng/>Yingying Zeng</a></span>, <span><a href=/author/evan-rosenberg/>Evan Rosenberg</a></span>, <span><a href=/author/tyler-graf/>Tyler Graf</a></span>, <span><a href=/author/kevin-j.-mchugh/>Kevin J. McHugh</a></span>, <span><a href=/author/stephany-t.-tzeng/>Stephany T. Tzeng</a></span>, <span>
14<a href=/author/adam-m.-behrens/>Adam M. Behrens</a></span>, <span><a href=/author/lisa-e.-freed/>Lisa E. Freed</a></span>, <span><a href=/author/lihong-jing/>Lihong Jing</a></span>, <span><a href=/author/surangi-jayawardena/>Surangi Jayawardena</a></span>, <span><a href=/author/shelly-b.-weinstock/>Shelly B. Weinstock</a></span>, <span><a href=/author/xiao-le/>Xiao Le</a></span>, <span><a href=/author/christopher-sears/>Christopher Sears</a></span>, <span><a href=/author/james-oxley/>James Oxley</a></span>, <span><a href=/author/john-l.-daristotle/>John L. Daristotle</a></span>, <span><a href=/author/joe-collins/>Joe Collins</a></span>, <span><a href=/author/robert-langer/>Robert Langer</a></span>, <span><a href=/author/ana-jaklenec/>Ana Jaklenec</a></span></div></div><div class=btn-links><a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1073/pnas.2211534119 target=_blank rel=noopener>PDF</a>
15<button type=button class="btn btn-outline-primary my-1 mr-1 btn-sm js-cite-modal" data-filename=/publication/vita/cite.bib>
16Cite</button>
17<a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1073/pnas.221153411 target=_blank rel=noopener>DOI</a></div></div><div class=ml-3><a href=/publication/vita/><img src=/publication/vita/featured_hu5b440f72c8a42fc9fea7851f38a770e1_2975021_fdd90acd68846737c6acfa807dd6b67e.jpg data-src=/publication/vita/featured_hu5b440f72c8a42fc9fea7851f38a770e1_2975021_150x0_resize_q75_lanczos.jpg alt="Enhanced stability and clinical absorption of a form of encapsulated vitamin A for food fortification" class=lazyload></a></div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/publication/sealmech/>Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles</a></h3><a href=/publication/sealmech/ class=summary-link><div class=article-style>Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A …</div></a><div class="stream-meta article-metadata"><div><span><a href=/author/morteza-sarmadi/>Morteza Sarmadi</a></span>, <span><a href=/author/christina-ta/>Christina Ta</a></span>, <span><a href=/author/abigail-m.-vanlonkhuyzen/>Abigail M. VanLonkhuyzen</a></span>, <span><a href=/author/dominique-c.-de-fiesta/>Dominique C. De Fiesta</a></span>, <span><a href=/author/maria-kanelli/>Maria Kanelli</a></span>, <span><a href=/author/ilin-sadeghi/>Ilin Sadeghi</a></span>, <span><a href=/author/adam-m.-behrens/>Adam M. Behrens</a></span>, <span><a href=/author/bailey-ingalls/>Bailey Ingalls</a></span>, <span><a href=/author/nandita-menon/>Nandita Menon</a></span>, <span><a href=/author/john-l.-daristotle/>John L. Daristotle</a></span>, <span><a href=/author/julie-yu/>Julie Yu</a></span>, <span><a href=/author/robert-langer/>Robert Langer</a></span>, <span><a href=/author/ana-jaklenec/>Ana Jaklenec</a></span></div></div><div class=btn-links><a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1126/sciadv.abn5315 target=_blank rel=noopener>PDF</a>
18<button type=button class="btn btn-outline-primary my-1 mr-1 btn-sm js-cite-modal" data-filename=/publication/sealmech/cite.bib>
19Cite</button>
20<a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1126/sciadv.abn531 target=_blank rel=noopener>DOI</a></div></div><div class=ml-3><a href=/publication/sealmech/><img src=/publication/sealmech/featured_huf8ad067d2e620e951165ca9302ec60ee_5080798_c7ccf41da195924f38f57c4af38a9393.jpg data-src=/publication/sealmech/featured_huf8ad067d2e620e951165ca9302ec60ee_5080798_150x0_resize_q75_lanczos.jpg alt="Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles" class=lazyload></a></div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/publication/adhesions/>Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions</a></h3><a href=/publication/adhesions/ class=summary-link><div class=article-style>Adhesions are dense, fibrous bridges that adjoin tissue surfaces due to uncontrolled inflammation following postoperative mesothelial …</div></a><div class="stream-meta article-metadata"><div><span><a href=/author/metecan-erdi/>Metecan Erdi</a></span>, <span><a href=/author/selim-rozyyev/>Selim Rozyyev</a></span>, <span><a href=/author/manogna-balabhadrapatrumi/>Manogna Balabhadrapatrumi</a></span>, <span><a href=/author/michele-s.-saruwatari/>Michele S. Saruwatari</a></span>, <span><a href=/author/john-l.-daristotle/>John L. Daristotle</a></span>, <span><a href=/author/omar-b.-ayyub/>Omar B. Ayyub</a></span>, <span><a href=/author/anthony-d.-sandler/>Anthony D. Sandler</a></span>, <span><a href=/author/peter-kofinas/>Peter Kofinas</a></span></div></div><div class=btn-links><a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1002/btm2.10335 target=_blank rel=noopener>PDF</a>
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23<a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1002/btm2.10335 target=_blank rel=noopener>DOI</a></div></div><div class=ml-3><a href=/publication/adhesions/><img src=/publication/adhesions/featured_huc11b7c8dc1d5234afa728f2820f
23cb3e5_166308_ca26c2cf7849663b79e1d01dffb84957.jpg data-src=/publication/adhesions/featured_huc11b7c8dc1d5234afa728f2820fcb3e5_166308_150x0_resize_q75_lanczos.jpg alt="Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions" class=lazyload></a></div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/publication/recell/>Evaluation of healing outcomes combining a novel polymer formulation with autologous skin cell suspension to treat deep partial and full thickness wounds in a porcine model: a pilot study</a></h3><a href=/publication/recell/ class=summary-link><div class=article-style><p>Autologous skin cell suspensions (ASCS) can treat burns of varying depths with the advantage of reduced donor site wound burden. The …</p></div></a><div class="stream-meta article-metadata"><div><span><a href=/author/bonnie-c.-carney/>Bonnie C. Carney</a></span>, <span><a href=/author/mary-a.-oliver/>Mary A. Oliver</a></span>, <span><a href=/author/metecan-erdi/>Metecan Erdi</a></span>, <span><a href=/author/liam-d.-kirkpatrick/>Liam D. Kirkpatrick</a></span>, <span><a href=/author/stephen-p.-tranchina/>Stephen P. Tranchina</a></span>, <span><a href=/author/selim-rozyyev/>Selim Rozyyev</a></span>, <span><a href=/author/john-w.-keyloun/>John W. Keyloun</a></span>, <span><a href=/author/michele-s.-saruwatari/>Michele S. Saruwatari</a></span>, <span><a href=/author/john-l.-daristotle/>John L. Daristotle</a></span>, <span><a href=/author/lauren-t.-moffatt/>Lauren T. Moffatt</a></span>, <span><a href=/author/peter-kofinas/>Peter Kofinas</a></span>, <span><a href=/author/anthony-d.-sandler/>Anthony D. Sandler</a></span>, <span><a href=/author/jeffrey-w.-shupp/>Jeffrey W. Shupp</a></span></div></div><div class=btn-links><a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1016/j.burns.2022.01.012 target=_blank rel=noopener>PDF</a>
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26<a class="btn btn-outline-primary my-1 mr-1 btn-sm" href=https://doi.org/10.1016/j.burns.2022.01.012 target=_blank rel=noopener>DOI</a></div></div><div class=ml-3></div></div><div class=see-all><a href=/publication/>See all publications
27<i class="fas fa-angle-right"></i></a></div></div></div></div></section><section id=talks class="home-section wg-pages"><div class=home-section-bg></div><div class=container><div class=row><div class="col-12 col-lg-4 section-heading"><h1>Recent & Upcoming Talks</h1></div><div class="col-12 col-lg-8"><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/talk/btm-2019/>Intrinsically Adhesive Polymer Wound Dressing with Antimicrobial Properties</a></h3><a href=/talk/btm-2019/ class=summary-link><div class=article-style>Conventional wound dressings are adhesive-coated thin films. They adhere primarily to healthy skin surrounding the wound, and have limited exudate absorption. Here, we demonstrate that polymer blend fibers can be sprayed directly into a partial-thickness skin wound using solution blow spinning, a fiber spinning technique. Due to a body temperature-mediated softening event, the fibrous wound dressing can stick immediately to the wound and skin. Within 3 days, the porous wound dressing has absorbed a significant amount of wound exudate, creating a polymer-scab hybrid material that is strongly bound to the wound. As a result, this wound dressing required 75% fewer dressing changes than a clinical control wound dressing. We tracked a number of additional wound healing metrics. Vascularization, as measured by blood vessel density in the healing wound, was significantly increased. Dermis and epidermis thickness, collagen content, and various gene and cytokine expression levels were comparable between dressings. We also engineered the controlled release of silver nitrate, a potent antimicrobial agent, without compromising adhesion or cytotoxicity.</div></a><div class="stream-meta article-metadata"><div><span>Oct 8, 2019 5:05 PM</span>
28<span class=middot-divider></span><span>Durham, NC, USA</span></div></div><div class=btn-links></div></div><div class=ml-3></div></div><div class="media stream-item"><div class=media-body>
28<h3 class="article-title mb-0 mt-0"><a href=/talk/mrs-2018/>Adhesive Polymer Composite Wound Dressings: Silver and Silica for Antimicrobial and Hemostatic Applications</a></h3><a href=/talk/mrs-2018/ class=summary-link><div class=article-style>Wound closure devices prevent excessive blood loss and exposure to pathogens, whether for internal or external use. Conformal, adhesive dressings improve upon conventional wound closure devices such as sutures by minimizing collateral damage to tissue and providing a leak-proof seal. In this work, we demonstrate how solution blow spinning (SBS) can be used to spray-deliver polymer composite dressings in situ&ndash;and how the composite element delivers advanced functionality, either by (1) releasing silver ions to prevent infection or (2) by incorporating silica particles to reduce coagulation time. Both approaches utilize a body temperature-responsive biodegradable polymer blend of poly(lactic-co-glycolic acid) and poly(ethylene glycol) (PLGA/PEG) with minimal cytotoxicity.</div></a><div class="stream-meta article-metadata"><div><span>Nov 20, 2018 9:30 AM</span>
29<span class=middot-divider></span><span>Boston, MA, USA</span></div></div><div class=btn-links></div></div><div class=ml-3></div></div><div class="media stream-item"><div class=media-body><h3 class="article-title mb-0 mt-0"><a href=/talk/acs-2018/>Incorporating silica particles improves the adhesion, flexibility, and hemostatic efficacy of a polymer blend surgical sealant</a></h3><a href=/talk/acs-2018/ class=summary-link><div class=article-style>Surgical sealants are supplements to conventional wound closure devices that augment hemostasis and may reduce complication rate. However, commercially available surgical sealants adhere poorly to wet tissue and are difficult to apply precisely. Here, solution blow spinning (SBS) serves as a sprayable deposition method for easily depositing conformal surgical sealants directly to the wound. The objective of this research is to increase tissue adhesion by incorporating nano-to-microscale particles into a poly(lactic-co-glycolic) acid and poly(ethylene glycol) blend sealant (PLGA/PEG) whose deposition is compatible with SBS. Our experiments focus on understanding how the silica particles interact at the interface with tissue, measuring adhesive interactions, and determining possible mechanisms for adhesion improvement which may be of broader interest to the field of surface science. Adhesion increases dramatically by incorporating silica particles into the PLGA/PEG blend surgical sealant, but does not cause a significant decrease in cell viability. Composite PLGA/PEG/SiO2 sealants produce intestinal burst pressures that are comparable to cyanoacrylate glue (156 mmHg), ~2 times greater than PLGA/PEG (59 mmHg), and ~3 times greater than fibrin glue (48.6 mmHg). Adhesive force increases by 20% while adhesion energy, which takes into account work dissipated by the bulk of the sealant, is 20 times higher. Scanning electron microscopy shows silica particles sandwiched at the interface between tissue and sealant, where they create dense networks of physical bonds. These improvements demonstrate the potential of a simple composite design to increase adhesion through physical, noncovalent mechanisms.</div></a><div class="stream-meta article-metadata"><div><span>Aug 20, 2018 3:20 PM</span>
30<span class=middot-divider></span><span>Boston, MA, USA</span></div></div><div class=btn-links></div></div><div class=ml-3><a href=/talk/acs-2018/><img src=/talk/acs-2018/featured_huf20cc50b8dc05ff3799b6d07462cce2d_1088897_217159c908936f4b78b74f7fd3f4dcea.jpg data-src=/talk/acs-2018/featured_huf20cc50b8dc05ff3799b6d07462cce2d_1088897_150x0_resize_q75_lanczos.jpg alt="Incorporating silica particles improves the adhesion, flexibility, and hemostatic efficacy of a polymer blend surgical sealant" class=lazyload></a></div></div><div class=see-all><a href=/talk/>See all talks
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