https://vitagram.manus.space/assets/DrugInteractions-2oT6sPWe.js

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49  <div class="header">
50    <div class="logo">Vitagram — Rapport Praticien</div>
51    <h1>Analyse des Interactions Médicamenteuses</h1>
52    <div class="subtitle">${n.title} &bull; Généré le ${new Date().toLocaleDateString("fr-FR",{day:"numeric",month:"long",year:"numeric"})} &bull; Bases de données : ANSM (France), BfArM (Allemagne), DrugBank/FDA (USA)</div>
53  </div>
54
55  <div class="section-title">Substances analysées (${n.substances.length})</div>
56  <div class="substances">
57    ${n.substances.map(_=>`<span class="substance-tag">${_.name.split(" (")[0]}</span>`).join("")}
58  </div>
59
60  <div class="section-title">Résumé des interactions</div>
61  <div class="summary-grid">
62    <div class="summary-card card-contraindicated">
63      <div class="count">${n.counts.contraindicated}</div>
64      <div class="label">Contre-indiquée(s)</div>
65    </div>
66    <div class="summary-card card-major">
67      <div class="count">${n.counts.major}</div>
68      <div class="label">Majeure(s)</div>
69    </div>
70    <div class="summary-card card-moderate">
71      <div class="count">${n.counts.moderate}</div>
72      <div class="label">Modérée(s)</div>
73    </div>
74    <div class="summary-card card-minor">
75      <div class="count">${n.counts.minor}</div>
76      <div class="label">Mineure(s)</div>
77    </div>
78  </div>
79
80  <div class="section-title">Détail des interactions (${k.length})</div>
81  ${k.length===0?'<div class="no-interactions">✓ Aucune interaction médicamenteuse connue détectée entre ces substances.</

81div>':k.map(_=>{const T=n.substances.find(E=>E.id===_.substance1),J=n.substances.find(E=>E.id===_.substance2);return`
82        <div class="interaction interaction-${_.severity}">
83          <div class="interaction-header">
84            <span class="severity-badge badge-${_.severity}">${B[_.severity]?.label??_.severity}</span>
85            <span class="interaction-title">${T?.name.split(" (")[0]??_.substance1} + ${J?.name.split(" (")[0]??_.substance2}</span>
86          </div>
87          <div class="field-label">Effet clinique</div>
88          <div class="field-value">${_.clinicalEffect}</div>
89          <div class="field-label">Mécanisme</div>
90          <div class="field-value">${_.mechanism}</div>
91          <div class="field-label">Recommandation</div>
92          <div class="field-value">${_.recommendation}</div>
93          ${_.alternatives?.length?`<div class="field-label">Alternatives</div><div class="field-value">${_.alternatives.join(", ")}</div>`:""}
94          <div class="field-label">Sources</div>
95          <div class="sources">${_.sources.map(E=>`<span class="source-tag">${E}</span>`).join("")}</div>
96        </div>`}).join("")}
97
98  ${n.aiAnalysis?`
99  <div class="ai-section">
100    <div class="ai-title">🧠 Analyse IA contextuelle</div>
101    <div class="ai-content">${n.aiAnalysis}</div>
102  </div>`:""}
103
104  <div class="footer">
105    Ce rapport est fourni à titre informatif pour les professionnels de santé. Il ne remplace pas l'avis d'un pharmacien ou d'un médecin.<br>
106    Sources : ANSM (Agence Nationale de Sécurité du Médicament), BfArM (Bundesinstitut für Arzneimittel und Medizinprodukte), DrugBank / FDA (Food and Drug Administration)<br>
107    Vitagram — ${new Date().getFullYear()}
108  </div>
109</body>
110</html>`;g.document.write(C),g.document.close(),setTimeout(()=>g.print(),500)},w=(()=>{if(!n)return null;const{contraindicated:g,major:y,moderate:k,minor:C,total:_}=n.counts;return g>0?{level:"Critique",color:"text-purple-700",bg:"bg-purple-50 border-purple-200"}:y>0?{level:"Élevé",color:"text-red-700",bg:"bg-red-50 border-red-200"}:k>0?{level:"Modéré",color:"text-amber-700",bg:"bg-amber-50 border-amber-200"}:C>0?{level:"Faible",color:"text-blue-700",bg:"bg-blue-50 border-blue-200"}:_===0?{level:"Aucun risque détecté",color:"text-green-700",bg:"bg-green-50 border-green-200"}:null})();return s.jsx(It,{"data-loc":"client/src/pages/DrugInteractions.tsx:704",children:s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:705",className:"max-w-5xl mx-auto px-4 py-6 space-y-6",children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:707",className:"flex items-start justify-between gap-4",children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:708",children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:709",className:"flex items-center gap-2 mb-1",children:[s.jsx(tt,{"data-loc":"client/src/pages/DrugInteractions.tsx:710",className:"h-6 w-6 text-cyan-600"}),s.jsx("h1",{"data-loc":"client/src/pages/DrugInteractions.tsx:711",className:"text-2xl font-bold text-slate-900",children:"Interactions Médicamenteuses"})]}),s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:713",className:"text-sm text-slate-500",children:["Analysez les interactions entre médicaments, plantes, compléments et aliments fonctionnels. Sources : ",s.jsx("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:715",className:"font-medium",children:"ANSM · BfArM · DrugBank/FDA"})]})]}),s.jsxs(V,{"data-loc":"client/src/pages/DrugInteractions.tsx:718",variant:"outline",size:"sm",className:"flex-shrink-0",onClick:()=>d(!f),children:[s.jsx(gt,{"data-loc":"client/src/pages/DrugInteractions.tsx:724",className:"h-4 w-4 mr-1.5"}),"Historique"]})]}),s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:730",className:"flex items-start gap-2.5 bg-amber-50 border border-amber-200 rounded-lg px-4 py-3 text-xs text-amber-800",children:[s.jsx(st,{"data-loc":"client/src/pages/DrugInteractions.tsx:731",className:"h-4 w-4 text-amber-500 flex-shrink-0 mt-0.5"}),s.jsxs("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:732",children:[s.jsx("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:733",className:"font-semibold",children:"Outil réservé aux professionnels de santé."}

110)," ","Les résultats sont générés par IA à partir des bases ANSM, BfArM et DrugBank/FDA. Ils ne remplacent pas l'avis d'un pharmacien ou d'un médecin. En cas de doute, consultez le Vidal ou un pharmacien avant toute décision thérapeutique."]})]}),f&&s.jsxs(O,{"data-loc":"client/src/pages/DrugInteractions.tsx:740",className:"border-slate-200",children:[s.jsx(Y,{"data-loc":"client/src/pages/DrugInteractions.tsx:741",className:"pb-3",children:s.jsxs(G,{"data-loc":"client/src/pages/DrugInteractions.tsx:742",className:"text-base flex items-center gap-2",children:[s.jsx(gt,{"data-loc":"client/src/pages/DrugInteractions.tsx:743",className:"h-4 w-4 text-slate-500"}),"Analyses précédentes"]})}),s.jsx(H,{"data-loc":"client/src/pages/DrugInteractions.tsx:747",children:!l||l.length===0?s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:749",className:"text-sm text-slate-400 text-center py-4",children:"Aucune analyse sauvegardée"}):s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:751",className:"space-y-2",children:l.map(g=>s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:753",className:"flex items-center justify-between p-3 rounded-lg border border-slate-100 hover:bg-slate-50 cursor-pointer",onClick:()=>{const y=(g.substanceNames??[]).map((k,C)=>({id:g.substances[C]??k,name:k,category:"medicament",description:"",commonUse:"",aliases:[]}));o(y),i({sessionId:g.id,substances:y,substanceNames:g.substanceNames??[],interactions:g.interactions??[],counts:{total:g.totalInteractions??0,contraindicated:g.contraindicatedInteractions??0,major:g.majorInteractions??0,moderate:g.moderateInteractions??0,minor:g.minorInteractions??0},aiAnalysis:g.aiAnalysis??"",title:g.title??""}),d(!1)},children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:785",children:[s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:786",className:"text-sm font-medium text-slate-800",children:g.title}),s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:787",className:"text-xs text-slate-400",children:[new Date(g.createdAt).toLocaleDateString("fr-FR")," •"," ",g.totalInteractions??0," interaction(s)"]})]}),s.jsx(V,{"data-loc":"client/src/pages/DrugInteractions.tsx:792",variant:"ghost",size:"sm",className:"h-7 w-7 p-0 text-slate-400 hover:text-red-500",onClick:y=>{y.stopPropagation(),v.mutate({id:g.id})},children:s.jsx(kt,{"data-loc":"client/src/pages/DrugInteractions.tsx:801",className:"h-3.5 w-3.5"})})]},g.id))})})]}),s.jsxs(O,{"data-loc":"client/src/pages/DrugInteractions.tsx:812",className:"border-slate-200",children:[s.jsx(Y,{"data-loc":"client/src/pages/DrugInteractions.tsx:813",className:"pb-3",children:s.jsxs(G,{"data-loc":"client/src/pages/DrugInteractions.tsx:814",className:"text-base flex items-center gap-2",children:[s.jsx(lt,{"data-loc":"client/src/pages/DrugInteractions.tsx:815",className:"h-4 w-4 text-slate-500"}),"Substances à analyser"]})}),s.jsxs(H,{"data-loc":"client/src/pages/DrugInteractions.tsx:819",className:"space-y-4",children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:821",className:"relative",children:[s.jsx(lt,{"data-loc":"client/src/pages/DrugInteractions.tsx:822",className:"absolute left-3 top-1/2 -translate-y-1/2 h-4 w-4 text-slate-400"}),s.jsx(ot,{"data-loc":"client/src/pages/DrugInteractions.tsx:823",ref:h,value:t,onChange:g=>e(g.target.value),placeholder:"Rechercher un médicament, plante, complément… (ex: millepertuis, warfarine)",className:"pl-9 pr-4"}),I&&s.jsx(dt,{"data-loc":"client/src/pages/DrugInteractions.tsx:831",className:"absolute right-3 top-1/2 -translate-y-1/2 h-4 w-4 text-slate-400 animate-spin"})]}),t.length>=2&&p&&p.length>0&&s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:837",className:"border border-slate-200 rounded-lg overflow-hidden shadow-sm",children:p.map(g=>{const y=a.some(k=>k.id===g.id);return s.jsxs("button",{"data-loc":"client/src/pages/DrugInteractions.tsx:841",className:`w-full text-left px-4 py-3 flex items-start gap-3 hover:bg-slate-50 border-b border-slate-100 last:border-0 transition-colors ${y?"o

110pacity-50 cursor-not-allowed":""}`,onClick:()=>!y&&N(g),disabled:y,children:[s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:847",className:"w-2 h-2 rounded-full mt-1.5 flex-shrink-0",style:{backgroundColor:K[g.category]??"#94a3b8"}}),s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:851",className:"min-w-0",children:[s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:852",className:"text-sm font-medium text-slate-800",children:g.name}),s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:853",className:"text-xs text-slate-500 mt-0.5",children:[be[g.category]??g.category," — ",g.commonUse]})]}),y?s.jsx("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:856",className:"text-xs text-slate-400 ml-auto flex-shrink-0",children:"Ajouté"}):s.jsx(jt,{"data-loc":"client/src/pages/DrugInteractions.tsx:858",className:"h-4 w-4 text-cyan-600 ml-auto flex-shrink-0"})]},g.id)})}),t.length>=2&&p?.length===0&&!I&&s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:867",className:"text-sm text-slate-400 text-center py-2",children:["Aucune substance trouvée pour « ",t," »"]}),a.length>0&&s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:872",children:[s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:873",className:"text-xs font-medium text-slate-500 mb-2",children:["Substances sélectionnées (",a.length,")"]}),s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:876",className:"flex flex-wrap gap-2",children:a.map(g=>s.jsxs("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:878",className:"inline-flex items-center gap-1.5 bg-white border border-slate-200 rounded-full px-3 py-1 text-sm text-slate-700 shadow-sm",children:[s.jsx("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:882",className:"w-2 h-2 rounded-full flex-shrink-0",style:{backgroundColor:K[g.category]??"#94a3b8"}}),g.name.split(" (")[0],s.jsx("button",{"data-loc":"client/src/pages/DrugInteractions.tsx:887",onClick:()=>c(g.id),className:"ml-0.5 text-slate-400 hover:text-red-500 transition-colors",children:s.jsx(Dt,{"data-loc":"client/src/pages/DrugInteractions.tsx:891",className:"h-3.5 w-3.5"})})]},g.id))})]}),a.length>=2&&s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:901",children:s.jsx(ot,{"data-loc":"client/src/pages/DrugInteractions.tsx:902",value:b,onChange:g=>j(g.target.value),placeholder:"Titre de l'analyse (optionnel)",className:"text-sm"})}),s.jsx(V,{"data-loc":"client/src/pages/DrugInteractions.tsx:912",onClick:D,disabled:a.length<2||r.isPending,className:"w-full bg-cyan-600 hover:bg-cyan-700 text-white",children:r.isPending?s.jsxs(s.Fragment,{children:[s.jsx(dt,{"data-loc":"client/src/pages/DrugInteractions.tsx:919",className:"h-4 w-4 mr-2 animate-spin"}),"Analyse en cours…"]}):s.jsxs(s.Fragment,{children:[s.jsx(tt,{"data-loc":"client/src/pages/DrugInteractions.tsx:924",className:"h-4 w-4 mr-2"}),"Analyser les interactions",a.length>=2&&s.jsxs("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:927",className:"ml-2 bg-white/20 rounded-full px-2 py-0.5 text-xs",children:[a.length," substances"]})]})})]})]}),n&&s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:939",className:"space-y-4",children:[w&&s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:942",className:`rounded-xl border p-4 flex items-center justify-between ${w.bg}`,children:[s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:943",children:[s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:944",className:"text-xs font-semibold text-slate-500 uppercase tracking-wide",children:"Niveau de risque global"}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:945",className:`text-xl font-bold 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text-red-700",children:n.counts.major}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:960",className:"text-xs text-red-600",children:"Majeure"})]}),n.counts.moderate>0&&s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:964",children:[s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:965",className:"text-2xl font-bold text-amber-700",children:n.counts.moderate}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:966",className:"text-xs text-amber-600",children:"Modérée"})]}),n.counts.minor>0&&s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:970",children:[s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:971",className:"text-2xl font-bold text-blue-700",children:n.counts.minor}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:972",className:"text-xs text-blue-600",children:"Mineure"})]})]})]}),s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:980",className:"flex items-center gap-1 bg-slate-100 rounded-lg p-1 

110w-fit",children:[{key:"list",label:"Liste",icon:Mt},{key:"matrix",label:"Matrice",icon:tt},{key:"graph",label:"Graphe",icon:ut}].map(g=>{const y=g.icon;return s.jsxs("button",{"data-loc":"client/src/pages/DrugInteractions.tsx:988",onClick:()=>x(g.key),className:`flex items-center gap-1.5 px-3 py-1.5 rounded-md text-sm font-medium transition-colors ${u===g.key?"bg-white text-slate-900 shadow-sm":"text-slate-500 hover:text-slate-700"}`,children:[s.jsx(y,{"data-loc":"client/src/pages/DrugInteractions.tsx:997",className:"h-3.5 w-3.5"}),g.label]},g.key)})}),u==="list"&&s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:1006",className:"space-y-3",children:n.interactions.length===0?s.jsxs("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:1008",className:"rounded-xl border border-green-200 bg-green-50 p-6 text-center",children:[s.jsx(W,{"data-loc":"client/src/pages/DrugInteractions.tsx:1009",className:"h-10 w-10 text-green-500 mx-auto mb-3"}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:1010",className:"font-semibold text-green-800",children:"Aucune interaction connue détectée"}),s.jsx("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:1011",className:"text-sm text-green-600 mt-1",children:"Ces substances ne présentent pas d'interactions répertoriées dans nos bases de données."})]}):n.interactions.map(g=>s.jsx(Ie,{"data-loc":"client/src/pages/DrugInteractions.tsx:1017",interaction:g,substances:n.substances},g.id))}),u==="matrix"&&s.jsxs(O,{"data-loc":"client/src/pages/DrugInteractions.tsx:1028",className:"border-slate-200",children:[s.jsx(Y,{"data-loc":"client/src/pages/DrugInteractions.tsx:1029",className:"pb-3",children:s.jsx(G,{"data-loc":"client/src/pages/DrugInteractions.tsx:1030",className:"text-base",children:"Matrice des interactions"})}),s.jsx(H,{"data-loc":"client/src/pages/DrugInteractions.tsx:1032",children:s.jsx(ye,{"data-loc":"client/src/pages/DrugInteractions.tsx:1033",substances:n.substances,interactions:n.interactions})})]}),u==="graph"&&s.jsxs(O,{"data-loc":"client/src/pages/DrugInteractions.tsx:1042",className:"border-slate-200",children:[s.jsx(Y,{"data-loc":"client/src/pages/DrugInteractions.tsx:1043",className:"pb-3",children:s.jsx(G,{"data-loc":"client/src/pages/DrugInteractions.tsx:1044",className:"text-base",children:"Graphe d'interactions"})}),s.jsxs(H,{"data-loc":"client/src/pages/DrugInteractions.tsx:1046",children:[s.jsx(ve,{"data-loc":"client/src/pages/DrugInteractions.tsx:1047",substances:n.substances,interactions:n.interactions}),s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:1051",className:"flex flex-wrap gap-3 mt-3 text-xs text-slate-600",children:Object.entries(B).filter(([g])=>g!=="none").map(([g,y])=>s.jsxs("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:1055",className:"flex items-center gap-1.5",children:[s.jsx("span",{"data-loc":"client/src/pages/DrugInteractions.tsx:1056",className:"w-4 h-0.5 rounded",style:{backgroundColor:y.d3Color}}),y.label]},g))})]})]}),n.aiAnalysis&&s.jsxs(O,{"data-loc":"client/src/pages/DrugInteractions.tsx:1067",className:"border-cyan-200 bg-cyan-50/50",children:[s.jsx(Y,{"data-loc":"client/src/pages/DrugInteractions.tsx:1068",className:"pb-3",children:s.jsxs(G,{"data-loc":"client/src/pages/DrugInteractions.tsx:1069",className:"text-base flex items-center gap-2 text-cyan-800",children:[s.jsx(ut,{"data-loc":"client/src/pages/DrugInteractions.tsx:1070",className:"h-4 w-4"}),"Analyse IA contextuelle"]})}),s.jsx(H,{"data-loc":"client/src/pages/DrugInteractions.tsx:1074",children:s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:1075",className:"text-sm text-slate-700 leading-relaxed prose prose-sm max-w-none prose-headings:text-slate-800 prose-strong:text-slate-800",children:s.jsx(yt,{"data-loc":"client/src/pages/DrugInteractions.tsx:1076",children:n.aiAnalysis})})})]}),s.jsx("div",{"data-loc":"client/src/pages/DrugInteractions.tsx:1083",className:"flex justify-end",children:s.jsxs(V,{"data-loc":"client/src/pages/DrugInteractions.tsx:1084",variant:"outline",onClick:A,className:"flex items-center gap-2",children:[s.jsx(Ct,{"data-loc":"client/src/pages/DrugInteractions.tsx:1089",className:"h-4 w-4"}),"Rapport praticien (PDF)"]})}),s.jsxs("p",{"data-loc":"client/src/pages/DrugInteractions.tsx:1095",className:"text-xs text-slate-400 text-center",children:["Ce rapport est fourni à titre informatif pour les professionnels de santé. Il ne remplace pas l'avis d'un pharmacien ou d'un médecin.",s.jsx("br",{"data-loc":"client/src/pages/DrugInteractions.tsx:1096"}),"Sources : ANSM (France) · BfArM (Allemagne) · DrugBank/FDA (USA)"]})]})]})})}export{Ee as default};