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1<meta name="theme-color" content="#000000"/><meta name="next-size-adjust" content=""/><title>ONCONEX Community — community learning</title><meta name="description" content="The pan-cancer nexus. Staging, biomarkers, trials, genomics, navigation — composed. Every claim sourced. Every variant classified. Every trial cited. The community has the evidence"/><link rel="manifest" href="/manifest.webmanifest"/><meta name="canonic-scope" content="onconex"/><meta property="og:title" content="ONCONEX Community"/><meta property="og:description" content="The pan-cancer nexus. Staging, biomarkers, trials, genomics, navigation — composed. Every claim sourced. Every variant classified. Every trial cited. The community has the evidence"/><meta property="og:type" content="website"/><meta name="twitter:card" content="summary"/><meta name="twitter:title" content="ONCONEX Community"/><meta name="twitter:description" content="The pan-cancer nexus. Staging, biomarkers, trials, genomics, navigation — composed. Every claim sourced. Every variant classified. Every trial cited. The community has the evidence"/><link rel="shortcut icon" href="/icon.svg"/><link rel="icon" href="/icon.svg"/><link rel="apple-touch-icon" href="/icon.svg"/>
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17<div class="relative flex min-h-dvh flex-col bg-background text-foreground" data-scope-accent="#00ff88" style="--scope-accent:#00ff88"><header data-role="surface-header" class="sticky top-0 z-10 flex h-12 shrink-0 items-center gap-3 border-b border-border/60 bg-background/90 px-3 backdrop-blur-md"><button type="button" aria-label="Open menu" aria-expanded="false" aria-controls="canonic-hamburger-drawer" title="Open menu" data-role="hamburger-trigger" class="inline-flex h-8 min-w-[32px] items-center justify-center rounded-md border border-border/60 bg-transparent text-base font-medium leading-none text-muted-foreground transition hover:bg-accent hover:text-foreground focus-visible:outline focus-visible:outline-2 focus-visible:outline-offset-2 focus-visible:outline-ring"><svg aria-hidden="true" width="16" height="12" viewBox="0 0 16 12" fill="none" xmlns="http://www.w3.org/2000/svg" class="pointer-events-none"><line x1="0" y1="1" x2="16" y2="1" stroke="currentColor" stroke-width="1.5" stroke-linecap="round"></line><line x1="0" y1="6" x2="16" y2="6" stroke="currentColor" stroke-width="1.5" stroke-linecap="round"></line><line x1="0" y1="11" x2="16" y2="11" stroke="currentColor" stroke-width="1.5" stroke-linecap="round"></line></svg></button><div class="ml-auto flex items-center gap-2"><button type="button" aria-label="Open LAUDE" aria-expanded="false" aria-controls="canonic-laude-rail" title="Open LAUDE (live)" data-role="laude-trigger" class="relative inline-flex items-center justify-center rounded-md border text-base font-medium leading-none transition focus-visible:outline focus-visible:outline-2 focus-visible:outline-offset-2 focus-visible:outline-ring bg-transparent text-muted-foreground border-border/60 hover:bg-accent hover:text-foreground h-8 min-w-[32px] laude-glow"><span aria-hidden="true">λ</span><span class="absolute -right-0.5 -top-0.5 inline-flex h-2 w-2" aria-hidden="true"><span class="absolute inline-flex h-full w-full animate-ping rounded-full bg-success opacity-75"></span><span class="relative inline-flex h-2 w-2 rounded-full bg-success"></span></span></button></div></header><div class="relative flex flex-1 overflow-hidden"><main id="main" class="flex min-h-screen w-full flex-1 flex-col"><div class="flex flex-1 flex-col"><div class="community-root"><div class="community-topbar"><a class="community-back" href="/chat/onconex">← <!-- -->ONCONEX</a></div><header class="community-hero"><div class="community-hero-content"><div class="community-hero-badge"><span class="community-badge-dot"></span>ONCONEX</div><h1 class="community-hero-title">OncoNex</h1><p class="community-hero-desc">The pan-cancer nexus. Staging, biomarkers, trials, genomics, navigation — composed. Every claim sourced. Every variant classified. Every trial cited. The community has the evidence at 3 AM.</p><div class="community-hero-ctas"><a class="community-btn-secondary" href="/chat/onconex">Open Chat →</a><a class="community-btn-primary" href="/onconex/community">Enter the Nexus</a><a class="community-btn-secondary" href="https://app.onconex.ai/">Try OncoNex</a></div><p class="community-hero-tagline">Every session evidenced · Every row ledgered · Zero PII stored</p></div><div class="community-hero-device"><div class="community-device-glow"></div><div class="community-iphone"><div class="community-iphone-shell"><div class="community-iphone-notch"></div><div class="community-iphone-screen"><div class="community-chat-header"><span class="community-chat-icon">🔬</span><span class="community-chat-name">OncoNex</span><span class="community-chat-status"></span></div><div class="community-iphone-chat"><div class="flex h-full min-h-0 flex-col overflow-hidden bg-background gap-1.5 rounded-md text-[10px]" data-scope="onconex" data-demo="true"><div role="log" aria-live="polite" aria-label="Chat transcript for onconex" aria-busy="false" class="flex-1 overflow-y-auto space-y-1.5 px-2 py-1.5"></div><div aria-hidden="true" class="flex items-end gap-1.5 border-t border-border bg-muted/40 px-2 py-1.5"><span data-autogrow="chat-input" class="flex-1 whitespace-pre-wrap break-words rounded-2xl px-2.5 py-1 text-[9px] leading-snug bg-muted text-muted-foreground">Ask <!-- -->onconex<!-- -->…</span><span class="grid h-4 w-4 place-items-center rounded-full bg-primary text-[8px] font-bold text-primary-foreground">↑</span></div></div></div></div><div class="community-iphone-home"></div></div></div></div></header><div class="community-body"><section class="community-section community-live"><h2 class="community-section-title">Live community</h2><p class="community-section-subtitle">
17Happening right now — every post ledgered, every upvote mints COIN.</p><div class="community-live-grid"><div class="community-live-threads"><div class="community-live-heading"><span>Recent threads</span><a class="community-live-all" href="/talk/onconex/community">View all →</a></div><div class="community-live-skel">Loading…</div><ul class="community-live-list"></ul></div><div class="community-live-leaders"><div class="community-live-heading"><span>Top contributors</span></div><div class="community-live-skel">Loading…</div><ul class="community-live-leaderlist"></ul></div></div></section><section class="community-section"><h2 class="community-section-title">Clinical Intelligence</h2><p class="community-section-subtitle">WHAT ONCONEX KNOWS</p><div class="community-metrics"><div class="community-metric"><div class="community-metric-value">6</div><div class="community-metric-label">specialized views</div></div><div class="community-metric"><div class="community-metric-value">3M+</div><div class="community-metric-label">pan-cancer records</div></div><div class="community-metric"><div class="community-metric-value">5,000+</div><div class="community-metric-label">active trials</div></div><div class="community-metric"><div class="community-metric-value">247/255</div><div class="community-metric-label">MAGIC governance</div></div></div></section><section class="community-section"><h2 class="community-section-title">Why the Nexus Exists</h2><p class="community-section-subtitle">THE FRAGMENTATION PROBLEM</p><p class="community-section-desc">Oncology is multidisciplinary by necessity and siloed in practice. Breast navigation lives in one system. Genomic pathology lives in another. Trial matching is a third. Resource-stratified care for Caribbean or community-practice settings is a fourth. OncoNex composes them — not as a dashboard over fragmented data, but as a governed intelligence layer where the evidence chain flows across specialty boundaries.</p><div class="community-grid community-grid-2"><article class="community-card"><div class="community-card-icon">🔎</div><p class="community-card-title">Staging is Incomplete Without Genomics</p><p class="community-card-text">AJCC 8th-edition pathologic stage is the anatomic skeleton. ACMG-classified variants, expression signatures, and molecular subtypes are the biology that actually drives therapy choice. OncoNex enriches every stage with the molecular context from OmicsChat — automatically.</p><div class="community-card-tags"><span class="community-tag community-tag-ajcc">AJCC</span><span class="community-tag community-tag-acmg">ACMG</span></div></article><article class="community-card"><div class="community-card-icon">🌹</div><p class="community-card-title">Breast Cancer Navigation is Local</p><p class="community-card-text">The same HR+/HER2- metastatic breast cancer patient gets different care pathways in Miami, Trinidad, Kingston, and rural Montana. OncoNex cross-references MammoChat&#x27;s BI-RADS + patient-navigation layer and CaribChat&#x27;s resource-stratified NCCN implementation with the staging logic.</p><div class="community-card-tags"><span class="community-tag community-tag-mammochat">MammoChat</span><span class="community-tag community-tag-caribchat">CaribChat</span></div></article><article class="community-card"><div class="community-card-icon">🔍</div><p class="community-card-title">Trials Are Mostly Not Where You Are</p><p class="community-card-text">5,000+ precision oncology trials are open. Most are at 20 comprehensive cancer centers. OncoNex surfaces trials by patient location + current accrual status + mCODE eligibility — not by marketing-friendly summaries that haven&#x27;t enrolled in six months.</p><div class="community-card-tags"><span class="community-tag community-tag-nct">NCT</span><span class="community-tag community-tag-mcode">mCODE</span></div></article><article class="community-card"><div class="community-card-icon">🕑</div><p class="community-card-title">NCCN Drifts Monthly. Tumor Boards Don&#x27;t.</p><p class="community-card-text">NCCN pushes minor-but-consequential revisions every few weeks. Most institutional tumor boards review updates quarterly. O
17ncoNex tracks version-to-version drift, flags the decisions your board last endorsed, and surfaces the community&#x27;s real-world debate on whether to adopt the new guidance today or wait.</p><div class="community-card-tags"><span class="community-tag community-tag-guidelines">Guidelines</span><span class="community-tag community-tag-governance">Governance</span></div></article></div></section><section class="community-section"><h2 class="community-section-title">Specialized Views</h2><p class="community-section-subtitle">SIX DIRECTED SURFACES FAN OUT FROM THE NEXUS</p><p class="community-section-desc">Each view is an audience-directed surface into the same governed INTEL graph. The nexus at onconex.ai composes them; users land on the view that matches their audience and workflow.</p><div class="community-grid community-grid-2"><a class="block" href="https://mammochat.ai"><article class="community-card"><p class="community-card-title">MAMMOCHAT</p><p class="community-card-text">MAMMOCHAT is community learning for patients navigating breast health:</p><div class="community-card-tags"><span class="community-tag community-tag-chat">CHAT</span><span class="community-tag community-tag-community">COMMUNITY</span></div></article></a><a class="block" href="https://caribchat.ai"><article class="community-card"><p class="community-card-title">CARIBCHAT</p><p class="community-card-text">CARIBCHAT is community learning for patients navigating Caribbean cancer care:</p><div class="community-card-tags"><span class="community-tag community-tag-chat">CHAT</span><span class="community-tag community-tag-community">COMMUNITY</span></div></article></a><a class="block" href="https://med.onconex.ai  # view of ONCONEX served at owned subdomain — medchat.ai UNOWNED (GoDaddy 2020, third-party; verified 2026-04-24 whois)"><article class="community-card"><p class="community-card-title">MEDCHAT</p><p class="community-card-text">MEDCHAT is community learning for internal medicine residents and overnight patients:</p><div class="community-card-tags"><span class="community-tag community-tag-chat">CHAT</span></div></article></a><a class="block" href="https://abopm.ai"><article class="community-card"><p class="community-card-title">ABOPM</p><p class="community-card-text">US precision medicine professionals</p><div class="community-card-tags"><span class="community-tag community-tag-chat">CHAT</span></div></article></a></div></section><section class="community-section"><h2 class="community-section-title">Evidence Chain</h2><p class="community-section-subtitle">WHERE ONCONEX GETS ITS ANSWERS</p><div class="community-grid community-grid-4"><article class="community-card"><div class="community-card-icon">📚</div><p class="community-card-title">NCCN</p><p class="community-card-text">National Comprehensive Cancer Network guidelines. The primary source for every staging decision, regimen choice, and biomarker gate. Version-tracked.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">📋</div><p class="community-card-title">AJCC 8th ed.</p><p class="community-card-text">American Joint Committee on Cancer staging manual, 8th edition. TNM by cancer type. Y-prefix for post-neoadjuvant pathologic staging.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">🧬</div><p class="community-card-title">ClinVar</p><p class="community-card-text">NCBI variant classification repository. ACMG/AMP evidence anchor routed via OmicsChat&#x27;s governed variant pipeline.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">🔬</div><p class="community-card-title">ClinicalTrials.gov</p><p class="community-card-text">5,000+ active precision-oncology trials. Matched by cancer type, biomarker profile, and mCODE eligibility — not by text search.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">🔧</div><p class="community-card-title">mCODE STU3</p><p class="community-card-text">Minimal Common Oncology Data Elements. FHIR-native structured oncology profile. Trial-matching backbone.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">💊</div><p class="community-card-title">CPIC</p><p class="community-card-text">
17Clinical Pharmacogenetics Implementation Consortium. Level A drug-gene dosing guidelines routed via OmicsChat.</p><div class="community-card-tags"><span class="community-tag community-tag-gold">GOLD</span></div></article><article class="community-card"><div class="community-card-icon">📊</div><p class="community-card-title">GEO / StarGEO</p><p class="community-card-text">NCBI Gene Expression Omnibus + StarGEO signature aggregation. Published in Nature Scientific Data 2017.</p><div class="community-card-tags"><span class="community-tag community-tag-silver">SILVER</span></div></article><article class="community-card"><div class="community-card-icon">🌎</div><p class="community-card-title">COSMIC</p><p class="community-card-text">Catalogue of Somatic Mutations in Cancer. Sanger Institute tumor-specific hotspots.</p><div class="community-card-tags"><span class="community-tag community-tag-silver">SILVER</span></div></article></div></section><section class="community-section"><h2 class="community-section-title">Partners</h2><p class="community-section-subtitle">THE INSTITUTIONS BEHIND ONCONEX</p><div class="community-grid community-grid-4"><article class="community-card"><div class="community-card-icon">🏛</div><p class="community-card-title">NIH / NCI</p><p class="community-card-text">National Institutes of Health, National Cancer Institute. StarGEO heritage (BD2K UH2CA203792). NCCN designation. TCGA + GDC.</p><div class="community-card-tags"><span class="community-tag community-tag-federal">Federal</span></div></article><article class="community-card"><div class="community-card-icon">🏫</div><p class="community-card-title">University of Central Florida</p><p class="community-card-text">Founding institution. Department of Internal Medicine, Clinical Medicine. AdventHealth Cancer Institute partnership.</p><div class="community-card-tags"><span class="community-tag community-tag-academic">Academic</span></div></article><article class="community-card"><div class="community-card-icon">👥</div><p class="community-card-title">AdventHealth</p><p class="community-card-text">51-hospital health system. Central Florida flagship. MammoChat deployment partner. Community-oncology footprint across the Southeast.</p><div class="community-card-tags"><span class="community-tag community-tag-health-system">Health system</span></div></article><article class="community-card"><div class="community-card-icon">∩</div><p class="community-card-title">CANONIC Foundation</p><p class="community-card-text">Governance framework. MAGIC 255 compliance. IRB oversight. Legal + ethical operating boundary. Community standards enforcement.</p><div class="community-card-tags"><span class="community-tag community-tag-governance">Governance</span></div></article><article class="community-card"><div class="community-card-icon">🧠</div><p class="community-card-title">ABOPM</p><p class="community-card-text">American Board of Precision Medicine. Certification framework. OmicsChat curriculum. Residents, fellows, attendings study here.</p><div class="community-card-tags"><span class="community-tag community-tag-credentialing">Credentialing</span></div></article><article class="community-card"><div class="community-card-icon">💭</div><p class="community-card-title">American Cancer Society</p><p class="community-card-text">ACS advocacy + patient-facing resource network. Community oncology programs. Survivorship + caregiver support infrastructure.</p><div class="community-card-tags"><span class="community-tag community-tag-advocacy">Advocacy</span></div></article><article class="community-card"><div class="community-card-icon">🎓</div><p class="community-card-title">Stanford Center for Biomedical Informatics</p><p class="community-card-text">Research affiliation. Butte Lab heritage — digital drug repositioning, biomedical data integration. Algorithmic evidence foundations.</p><div class="community-card-tags"><span class="community-tag community-tag-research">Research</span></div></article></div></section><section class="community-section"><h2 class="community-section-title">Access</h2><p class="community-section-subtitle">FREE FOR EDUCATION · FOUNDATION FOR PRACTICE · ENTERPRISE FOR INSTITUTIONS</p><div class="community-tiers"><div class="community-tier"><div class="community-tier-name">Free</div><div class="community-tier-price"><span class="community-tier-currency">$</span><span class="community-tier-amount">0</span><span class="community-tier-period">forever</span></div><p class="community-tier-sub">Forever. No sign-in.</p><ul class="community-tier-features"><li class="community-tier-feature"><span class="community-tier-check">✓</span>Pan-cancer staging lookup</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>AJCC 8th-ed. TNM by cancer type</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Biomarker-context summaries</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Community reads (public threads)</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Federated feed from all six views</li></ul><a class="community-btn-secondary" href="/onconex/community">Start now</a></div><div class="community-tier community-tier-featured"><div class="community-tier-badge">Most Popular</div><div class="community-tier-name">Foundation</div><div class="community-tier-price"><span class="community-tier-currency">$</span><span class="community-tier-amount">0</span><span class="community-tier-period">forever</span></div><p class="community-tier-sub">Credentialed clinicians. Governed by the Foundation.</p><ul class="community-tier-features"><li class="community-tier-feature"><span class="community-tier-check">✓</span>Community posting + voting</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>COIN minting on every post (1-2 per action)</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Rank progression (listener → elder)</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Private institutional reads</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Tumor-board-session export</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>
17ACMG variant classification (via OmicsChat)</li></ul><a class="community-btn-primary" href="https://canonic.org/foundation">Credential via CANONIC</a></div><div class="community-tier"><div class="community-tier-name">Enterprise</div><div class="community-tier-price"><span class="community-tier-currency">$</span><span class="community-tier-amount">Contact</span></div><p class="community-tier-sub">Cancer centers + research consortia.</p><ul class="community-tier-features"><li class="community-tier-feature"><span class="community-tier-check">✓</span>ENTERPRISE-gated tags (case_conference)</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Multi-disciplinary tumor board protocol generation</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Federated authoring across all six views</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Dedicated onboarding + audit trail</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>Custom evidence-chain extensions</li><li class="community-tier-feature"><span class="community-tier-check">✓</span>SSO + role-based credentialing</li></ul><a class="community-btn-secondary" href="mailto:[email protected]">Talk to us</a></div></div></section><section class="community-section"><h2 class="community-section-title">Governance</h2><p class="community-section-subtitle">MAGIC 247/255 · RISING</p><div class="community-grid community-grid-2"><a class="block" href="https://canonic.org/magic/"><article class="community-card"><div class="community-card-icon">∩</div><p class="community-card-title">Every reply ledgered. Every claim sourced. Every variant classified.</p><p class="community-card-text">OncoNex operates under CANONIC governance. Every community write mints COIN per SERVICES/COIN/CANON.md § Mint Table. Every COIN mint writes a hash-chained row in SERVICES/LEDGER. Every thread&#x27;s scope, federation edges, and metadata schema are compiled from CANON.md — there is no ungoverned surface. The nexus is a governed surface, not an aggregator. The community has the evidence at 3 AM because the evidence was governed before the patient walked in.</p><div class="community-card-tags"><span class="community-tag community-tag-247-255">247/255</span></div></article></a></div></section><footer class="community-footer"><div class="community-footer-brand"><span class="community-footer-mark">∩</span><span>ONCONEX</span><span class="community-footer-tagline">· <!-- -->OncoNex | A Hadley Lab Production · The oncology forum at onconex.ai</span></div><div class="community-footer-meta"><code>onconex.ai</code></div></footer></div></div><!--$--><!--/$--></div></main></div></div><div data-role="hud-bar" class="fixed right-4 top-4 z-40 hidden items-center gap-1 rounded-lg border border-border/60 bg-background/90 p-1 shadow-lg backdrop-blur-md lg:flex"></div>
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