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450}}" target="_blank" data-cmp-clickable>
451					<span translate="no" aria-hidden="true" class="material-symbols-rounded notranslate">arrow_back</span>
452					<span>BACK</span>
453					
454					
455					</a>
456				
457				
458			
459			
460			
461			
462
463			
464			
465            
466			
467			
468		</li>
469	</ul>
470</div>
471
472                </div>
473                <div class="hamburger-container-close">
474                    <div class="global-link cmp-global-link-link step--1 cmp-icon-size-s">
475	
476    
477
478    
479	<ul>
480		<li>
481			
482				
483				
484					<!--  Not dowload -->
485					<a href="#" data-cmp-data-layer="{&#34;global-link-73ee9e13cd-headerlink-item0null&#34;:{
486  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
487  &#34;xdm:linkType&#34; : &#34;internal&#34;,
488  &#34;xdm:linkURL&#34; : &#34;#&#34;,
489  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
490  &#34;dc:title&#34; : &#34;CLOSE&#34;
491}}" target="_blank" data-cmp-clickable>
492					
493					<span>CLOSE</span>
494					
495					<span translate="no" aria-hidden="true" class="material-symbols-rounded notranslate">close</span>
496					</a>
497				
498				
499			
500			
501			
502			
503
504			
505			
506            
507			
508			
509		</li>
510	</ul>
511</div>
512
513                </div>
514            </div>
515        </div>
516
517        <div class="nav above-brand-nav__rightnav cmp-desktop-show">
518            
519            
520            
521<div class="cmp-nav">
522    
523</div>
524
525        </div>
526        
527    </div>
528</div></div>
529<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
530    
531
532
533
534
535
536
537<div class="modal_bg ">
538</div>
539<div class="modal confirmation_modal ast-padding__inline--0  previewModel " id="hcp" data-cmp-data-layer="{&#34;hcp&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;hcp&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-02T16:33:22Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
540    <div class="u-container">
541         <div class="modal-dialog modal-dialog-centered ">
542            <div class="modal-dialog" role="document">
543                <div class="modal-content ast-information-card__container">
544                    <div class="ast-card__top ast-color__bg--surface">
545                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
546                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
547                        <div class="ast-color__bg--red ast-card__top-rec"></div>
548                    </div>
549                    
550                    
551                    <div class="ast-margin__inline--sm">
552                        
553                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
554                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="hcpHeading">
555                                <div class="text bottom-space-s bold-styling step-3">
556<div data-cmp-data-layer="{&#34;text-417dbaa4f0&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T19:38:51Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>This is a healthcare professional site&lt;/h2>\r\n&#34;}}" id="text-417dbaa4f0" class="cmp-text">
557    <h2>This is a healthcare professional site</h2>
558
559</div>
560
561    
562
563</div>
564
565                            </div>
566                        </div>
567                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
568                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
569                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
570<div data-cmp-data-layer="{&#34;text-fcbbeb1c0e&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T09:16:51Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>The information contained on the site is intended for&amp;nbsp;US healthcare professionals only. By selecting “Okay” below, you verify that you are a licensed&amp;nbsp;US healthcare professional.&lt;/p>\r\n&#34;}}" id="text-fcbbeb1c0e" class="cmp-text">
571    <p>The information contained on the site is intended for US healthcare professionals only. By selecting “Okay” below, you verify that you are a licensed US healthcare professional.</p>
572
573</div>
574
575    
576
577</div>
578
579                            </div>
580                        </div>
581                        
582                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
583
584                            <div>
585                                <div class="container responsivegrid">
586
587    
588    
589    
590    
591    
592    
593
594    <div id="container-b4ff6e55e3" class="cmp-container">
595    
596    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
597	
598    
599
600    
601	<ul>
602		<li>
603			
604			
605			
606			
607
608			
609				
610					
611						<a href="javascript:void(0);" class="actionStoreCookie" data-modal-id="hcp" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-b4e0d527d0-headerlink-item0null&#34;:{
612  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
613  &#34;xdm:linkType&#34; : &#34;internal&#34;,
614  &#34;xdm:linkURL&#34; : &#34;#&#34;,
615  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
616  &#34;dc:title&#34; : &#34;Okay&#34;
617}}" target="_self" data-cmp-clickable>
618							
619							<span>Okay</span>
620							 
621						</a>
622					
623					
624				
625				
626			
627			
628            
629			
630			
631		</li>
632	
633		<li>
634			
635			
636			
637			
638
639			
640				
641					
642						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="openpage" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-b4e0d527d0-headerlink-item1null&#34;:{
643  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
644  &#34;xdm:linkType&#34; : &#34;internal&#34;,
645  &#34;xdm:linkURL&#34; : &#34;#&#34;,
646  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
647  &#34;dc:title&#34; : &#34;No&#34;
648}}" target="_self" data-cmp-clickable>
649							
650							<span>No</span>
651							 
652						</a>
653					
654					
655				
656				
657			
658			
659            
660			
661			
662		</li>
663	</ul>
664</div>
665
666    
667    </div>
668
669</div>
670
671                            </div>
672
673                            
674                        </div>
675                    </div>
676                </div>
677            </div>
678        </div>
679    </div>
680</div>
681</div>
682<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
683    
684
685
686
687
688
689
690<div class="modal_bg modalHide">
691</div>
692<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-1" data-cmp-data-layer="{&#34;redirect-1&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-1&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:09:40Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
693    <div class="u-container">
694         <div class="modal-dialog modal-dialog-centered ">
695            <div class="modal-dialog" role="document">
696                <div class="modal-content ast-information-card__container">
697                    <div class="ast-card__top ast-color__bg--surface">
698                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
699                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
700                        <div class="ast-color__bg--red ast-card__top-rec"></div>
701                    </div>
702                    
703                    
704                    <div class="ast-margin__inline--sm">
705                        
706                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
707                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-1Heading">
708                                <div class="text bottom-space-s bold-styling step-3">
709<div data-cmp-data-layer="{&#34;text-2b96d59886&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-2b96d59886" class="cmp-text">
710    <h2>Thank you for visiting</h2>
711
712</div>
713
714    
715
716</div>
717
718                            </div>
719                        </div>
720                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
721                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
722                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
723<div data-cmp-data-layer="{&#34;text-a4247578e7&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-a4247578e7" class="cmp-text">
724    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
725
726</div>
727
728    
729
730</div>
731
732                            </div>
733                        </div>
734                        
735                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
736
737                            <div>
738                                <div class="container responsivegrid">
739
740    
741    
742    
743    
744    
745    
746
747    <div id="container-54679680fb" class="cmp-container">
748    
749    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
750	
751    
752
753    
754	<ul>
755		<li>
756			
757			
758			
759			
760
761			
762				
763				
764					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.astellas.com/en/privacy-policy" data-cmp-data-layer="{&#34;global-link-de60aa70e3-headerlink-item0null&#34;:{
765  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
766  &#34;xdm:linkType&#34; : &#34;external&#34;,
767  &#34;xdm:linkURL&#34; : &#34;https://www.astellas.com/en/privacy-policy&#34;,
768  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
769  &#34;dc:title&#34; : &#34;Continue&#34;
770}}" target="_blank" data-cmp-clickable>
771					
772					<span>Continue</span>
773					
774					
775					</a>
776				
777			
778			
779            
780			
781			
782		</li>
783	
784		<li>
785			
786			
787			
788			
789
790			
791				
792					
793						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-de60aa70e3-headerlink-item1null&#34;:{
794  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
795  &#34;xdm:linkType&#34; : &#34;internal&#34;,
796  &#34;xdm:linkURL&#34; : &#34;#&#34;,
797  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
798  &#34;dc:title&#34; : &#34;Cancel&#34;
799}}" target="_self" data-cmp-clickable>
800							
801							<span>Cancel</span>
802							 
803						</a>
804					
805					
806				
807				
808			
809			
810            
811			
812			
813		</li>
814	</ul>
815</div>
816
817    
818    </div>
819
820</div>
821
822                            </div>
823
824                            
825                        </div>
826                    </div>
827                </div>
828            </div>
829        </div>
830    </div>
831</div>
832</div>
833<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
834    
835
836
837
838
839
840
841<div class="modal_bg modalHide">
842</div>
843<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-2" data-cmp-data-layer="{&#34;redirect-2&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-2&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:21:30Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
844    <div class="u-container">
845         <div class="modal-dialog modal-dialog-centered ">
846            <div class="modal-dialog" role="document">
847                <div class="modal-content ast-information-card__container">
848                    <div class="ast-card__top ast-color__bg--surface">
849                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
850                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
851                        <div class="ast-color__bg--red ast-card__top-rec"></div>
852                    </div>
853                    
854                    
855                    <div class="ast-margin__inline--sm">
856                        
857                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
858                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-2Heading">
859                                <div class="text bottom-space-s bold-styling step-3">
860<div data-cmp-data-layer="{&#34;text-40c35d3100&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-40c35d3100" class="cmp-text">
861    <h2>Thank you for visiting</h2>
862
863</div>
864
865    
866
867</div>
868
869                            </div>
870                        </div>
871                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
872                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
873                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
874<div data-cmp-data-layer="{&#34;text-f142fbc27f&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-f142fbc27f" class="cmp-text">
875    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
876
877</div>
878
879    
880
881</div>
882
883                            </div>
884                        </div>
885                        
886                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
887
888                            <div>
889                                <div class="container responsivegrid">
890
891    
892    
893    
894    
895    
896    
897
898    <div id="container-6b037f644f" class="cmp-container">
899    
900    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
901	
902    
903
904    
905	<ul>
906		<li>
907			
908			
909			
910			
911
912			
913				
914				
915					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.astellas.com/en/contact-us" data-cmp-data-layer="{&#34;global-link-27fc94ad01-headerlink-item0null&#34;:{
916  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
917  &#34;xdm:linkType&#34; : &#34;external&#34;,
918  &#34;xdm:linkURL&#34; : &#34;https://www.astellas.com/en/contact-us&#34;,
919  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
920  &#34;dc:title&#34; : &#34;Continue&#34;
921}}" target="_blank" data-cmp-clickable>
922					
923					<span>Continue</span>
924					
925					
926					</a>
927				
928			
929			
930            
931			
932			
933		</li>
934	
935		<li>
936			
937			
938			
939			
940
941			
942				
943					
944						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-27fc94ad01-headerlink-item1null&#34;:{
945  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
946  &#34;xdm:linkType&#34; : &#34;internal&#34;,
947  &#34;xdm:linkURL&#34; : &#34;#&#34;,
948  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
949  &#34;dc:title&#34; : &#34;Cancel&#34;
950}}" target="_self" data-cmp-clickable>
951							
952							<span>Cancel</span>
953							 
954						</a>
955					
956					
957				
958				
959			
960			
961            
962			
963			
964		</li>
965	</ul>
966</div>
967
968    
969    </div>
970
971</div>
972
973                            </div>
974
975                            
976                        </div>
977                    </div>
978                </div>
979            </div>
980        </div>
981    </div>
982</div>
983</div>
984<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
985    
986
987
988
989
990
991
992<div class="modal_bg modalHide">
993</div>
994<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-3" data-cmp-data-layer="{&#34;redirect-3&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-3&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:09:56Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
995    <div class="u-container">
996         <div class="modal-dialog modal-dialog-centered ">
997            <div class="modal-dialog" role="document">
998                <div class="modal-content ast-information-card__container">
999                    <div class="ast-card__top ast-color__bg--surface">
1000                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1001                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1002                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1003                    </div>
1004                    
1005                    
1006                    <div class="ast-margin__inline--sm">
1007                        
1008                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1009                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-3Heading">
1010                                <div class="text bottom-space-s bold-styling step-3">
1011<div data-cmp-data-layer="{&#34;text-2ec8317930&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-2ec8317930" class="cmp-text">
1012    <h2>Thank you for visiting</h2>
1013
1014</div>
1015
1016    
1017
1018</div>
1019
1020                            </div>
1021                        </div>
1022                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
1023                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
1024                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1025<div data-cmp-data-layer="{&#34;text-0d6e88d9b9&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-0d6e88d9b9" class="cmp-text">
1026    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1027
1028</div>
1029
1030    
1031
1032</div>
1033
1034                            </div>
1035                        </div>
1036                        
1037                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1038
1039                            <div>
1040                                <div class="container responsivegrid">
1041
1042    
1043    
1044    
1045    
1046    
1047    
1048
1049    <div id="container-a9f4ead22b" class="cmp-container">
1050    
1051    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1052	
1053    
1054
1055    
1056	<ul>
1057		<li>
1058			
1059			
1060			
1061			
1062
1063			
1064				
1065				
1066					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.modernpathology.org/article/S0893-3952(24)00169-8/fulltext" data-cmp-data-layer="{&#34;global-link-dcbeedf9d0-headerlink-item0null&#34;:{
1067  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1068  &#34;xdm:linkType&#34; : &#34;external&#34;,
1069  &#34;xdm:linkURL&#34; : &#34;https://www.modernpathology.org/article/S0893-3952(24)00169-8/fulltext&#34;,
1070  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1071  &#34;dc:title&#34; : &#34;Continue&#34;
1072}}" target="_blank" data-cmp-clickable>
1073					
1074					<span>Continue</span>
1075					
1076					
1077					</a>
1078				
1079			
1080			
1081            
1082			
1083			
1084		</li>
1085	
1086		<li>
1087			
1088			
1089			
1090			
1091
1092			
1093				
1094					
1095						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-dcbeedf9d0-headerlink-item1null&#34;:{
1096  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
1097  &#34;xdm:linkType&#34; : &#34;internal&#34;,
1098  &#34;xdm:linkURL&#34; : &#34;#&#34;,
1099  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1100  &#34;dc:title&#34; : &#34;Cancel&#34;
1101}}" target="_self" data-cmp-clickable>
1102							
1103							<span>Cancel</span>
1104							 
1105						</a>
1106					
1107					
1108				
1109				
1110			
1111			
1112            
1113			
1114			
1115		</li>
1116	</ul>
1117</div>
1118
1119    
1120    </div>
1121
1122</div>
1123
1124                            </div>
1125
1126                            
1127                        </div>
1128                    </div>
1129                </div>
1130            </div>
1131        </div>
1132    </div>
1133</div>
1134</div>
1135<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1136    
1137
1138
1139
1140
1141
1142
1143<div class="modal_bg modalHide">
1144</div>
1145<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-4" data-cmp-data-layer="{&#34;redirect-4&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-4&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:10:03Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1146    <div class="u-container">
1147         <div class="modal-dialog modal-dialog-centered ">
1148            <div class="modal-dialog" role="document">
1149                <div class="modal-content ast-information-card__container">
1150                    <div class="ast-card__top ast-color__bg--surface">
1151                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1152                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1153                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1154                    </div>
1155                    
1156                    
1157                    <div class="ast-margin__inline--sm">
1158                        
1159                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1160                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-4Heading">
1161                                <div class="text bottom-space-s bold-styling step-3">
1162<div data-cmp-data-layer="{&#34;text-257d22833e&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-257d22833e" class="cmp-text">
1163    <h2>Thank you for visiting</h2>
1164
1165</div>
1166
1167    
1168
1169</div>
1170
1171                            </div>
1172                        </div>
1173                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
1174                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
1175                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1176<div data-cmp-data-layer="{&#34;text-5e01efa91e&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-5e01efa91e" class="cmp-text">
1177    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1178
1179</div>
1180
1181    
1182
1183</div>
1184
1185                            </div>
1186                        </div>
1187                        
1188                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1189
1190                            <div>
1191                                <div class="container responsivegrid">
1192
1193    
1194    
1195    
1196    
1197    
1198    
1199
1200    <div id="container-755e66480f" class="cmp-container">
1201    
1202    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1203	
1204    
1205
1206    
1207	<ul>
1208		<li>
1209			
1210			
1211			
1212			
1213
1214			
1215				
1216				
1217					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://link.springer.com/article/10.1007/s10120-024-01518-1" data-cmp-data-layer="{&#34;global-link-b78a772f86-headerlink-item0null&#34;:{
1218  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1219  &#34;xdm:linkType&#34; : &#34;external&#34;,
1220  &#34;xdm:linkURL&#34; : &#34;https://link.springer.com/article/10.1007/s10120-024-01518-1&#34;,
1221  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1222  &#34;dc:title&#34; : &#34;Continue&#34;
1223}}" target="_blank" data-cmp-clickable>
1224					
1225					<span>Continue</span>
1226					
1227					
1228					</a>
1229				
1230			
1231			
1232            
1233			
1234			
1235		</li>
1236	
1237		<li>
1238			
1239			
1240			
1241			
1242
1243			
1244				
1245					
1246						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-b78a772f86-headerlink-item1null&#34;:{
1247  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
1248  &#34;xdm:linkType&#34; : &#34;internal&#34;,
1249  &#34;xdm:linkURL&#34; : &#34;#&#34;,
1250  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1251  &#34;dc:title&#34; : &#34;Cancel&#34;
1252}}" target="_self" data-cmp-clickable>
1253							
1254							<span>Cancel</span>
1255							 
1256						</a>
1257					
1258					
1259				
1260				
1261			
1262			
1263            
1264			
1265			
1266		</li>
1267	</ul>
1268</div>
1269
1270    
1271    </div>
1272
1273</div>
1274
1275                            </div>
1276
1277                            
1278                        </div>
1279                    </div>
1280                </div>
1281            </div>
1282        </div>
1283    </div>
1284</div>
1285</div>
1286<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1287    
1288
1289
1290
1291
1292
1293
1294<div class="modal_bg modalHide">
1295</div>
1296<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-5" data-cmp-data-layer="{&#34;redirect-5&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-5&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:10:11Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1297    <div class="u-container">
1298         <div class="modal-dialog modal-dialog-centered ">
1299            <div class="modal-dialog" role="document">
1300                <div class="modal-content ast-information-card__container">
1301                    <div class="ast-card__top ast-color__bg--surface">
1302                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1303                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1304                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1305                    </div>
1306                    
1307                    
1308                    <div class="ast-margin__inline--sm">
1309                        
1310                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1311                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-5Heading">
1312                                <div class="text bottom-space-s bold-styling step-3">
1313<div data-cmp-data-layer="{&#34;text-382cf36d1b&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-382cf36d1b" class="cmp-text">
1314    <h2>Thank you for visiting</h2>
1315
1316</div>
1317
1318    
1319
1320</div>
1321
1322                            </div>
1323                        </div>
1324                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
1325                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
1326                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1327<div data-cmp-data-layer="{&#34;text-92f41987e4&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-92f41987e4" class="cmp-text">
1328    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1329
1330</div>
1331
1332    
1333
1334</div>
1335
1336                            </div>
1337                        </div>
1338                        
1339                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1340
1341                            <div>
1342                                <div class="container responsivegrid">
1343
1344    
1345    
1346    
1347    
1348    
1349    
1350
1351    <div id="container-085d39dc3d" class="cmp-container">
1352    
1353    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1354	
1355    
1356
1357    
1358	<ul>
1359		<li>
1360			
1361			
1362			
1363			
1364
1365			
1366				
1367				
1368					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.modernpathology.org/article/S0893-3952(25)00141-3/fulltext" data-cmp-data-layer="{&#34;global-link-66de1b0fd5-headerlink-item0null&#34;:{
1369  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1370  &#34;xdm:linkType&#34; : &#34;external&#34;,
1371  &#34;xdm:linkURL&#34; : &#34;https://www.modernpathology.org/article/S0893-3952(25)00141-3/fulltext&#34;,
1372  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1373  &#34;dc:title&#34; : &#34;Continue&#34;
1374}}" target="_blank" data-cmp-clickable>
1375					
1376					<span>Continue</span>
1377					
1378					
1379					</a>
1380				
1381			
1382			
1383            
1384			
1385			
1386		</li>
1387	
1388		<li>
1389			
1390			
1391			
1392			
1393
1394			
1395				
1396					
1397						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-66de1b0fd5-headerlink-item1null&#34;:{
1398  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
1399  &#34;xdm:linkType&#34; : &#34;internal&#34;,
1400  &#34;xdm:linkURL&#34; : &#34;#&#34;,
1401  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1402  &#34;dc:title&#34; : &#34;Cancel&#34;
1403}}" target="_self" data-cmp-clickable>
1404							
1405							<span>Cancel</span>
1406							 
1407						</a>
1408					
1409					
1410				
1411				
1412			
1413			
1414            
1415			
1416			
1417		</li>
1418	</ul>
1419</div>
1420
1421    
1422    </div>
1423
1424</div>
1425
1426                            </div>
1427
1428                            
1429                        </div>
1430                    </div>
1431                </div>
1432            </div>
1433        </div>
1434    </div>
1435</div>
1436</div>
1437<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1438    
1439
1440
1441
1442
1443
1444
1445<div class="modal_bg modalHide">
1446</div>
1447<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-6" data-cmp-data-layer="{&#34;redirect-6&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-6&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:10:18Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1448    <div class="u-container">
1449         <div class="modal-dialog modal-dialog-centered ">
1450            <div class="modal-dialog" role="document">
1451                <div class="modal-content ast-information-card__container">
1452                    <div class="ast-card__top ast-color__bg--surface">
1453                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1454                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1455                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1456                    </div>
1457                    
1458                    
1459                    <div class="ast-margin__inline--sm">
1460                        
1461                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1462                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-6Heading">
1463                                <div class="text bottom-space-s bold-styling step-3">
1464<div data-cmp-data-layer="{&#34;text-d9f022bd0d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-d9f022bd0d" class="cmp-text">
1465    <h2>Thank you for visiting</h2>
1466
1467</div>
1468
1469    
1470
1471</div>
1472
1473                            </div>
1474                        </div>
1475                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
1476                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
1477                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1478<div data-cmp-data-layer="{&#34;text-1cb98a3354&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-1cb98a3354" class="cmp-text">
1479    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1480
1481</div>
1482
1483    
1484
1485</div>
1486
1487                            </div>
1488                        </div>
1489                        
1490                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1491
1492                            <div>
1493                                <div class="container responsivegrid">
1494
1495    
1496    
1497    
1498    
1499    
1500    
1501
1502    <div id="container-8b33b24554" class="cmp-container">
1503    
1504    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1505	
1506    
1507
1508    
1509	<ul>
1510		<li>
1511			
1512			
1513			
1514			
1515
1516			
1517				
1518				
1519					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.sciencedirect.com/science/article/pii/S0023683723002271" data-cmp-data-layer="{&#34;global-link-9ad794dd0d-headerlink-item0null&#34;:{
1520  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1521  &#34;xdm:linkType&#34; : &#34;external&#34;,
1522  &#34;xdm:linkURL&#34; : &#34;https://www.sciencedirect.com/science/article/pii/S0023683723002271&#34;,
1523  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1524  &#34;dc:title&#34; : &#34;Continue&#34;
1525}}" target="_blank" data-cmp-clickable>
1526					
1527					<span>Continue</span>
1528					
1529					
1530					</a>
1531				
1532			
1533			
1534            
1535			
1536			
1537		</li>
1538	
1539		<li>
1540			
1541			
1542			
1543			
1544
1545			
1546				
1547					
1548						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-9ad794dd0d-headerlink-item1null&#34;:{
1549  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
1550  &#34;xdm:linkType&#34; : &#34;internal&#34;,
1551  &#34;xdm:linkURL&#34; : &#34;#&#34;,
1552  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1553  &#34;dc:title&#34; : &#34;Cancel&#34;
1554}}" target="_self" data-cmp-clickable>
1555							
1556							<span>Cancel</span>
1557							 
1558						</a>
1559					
1560					
1561				
1562				
1563			
1564			
1565            
1566			
1567			
1568		</li>
1569	</ul>
1570</div>
1571
1572    
1573    </div>
1574
1575</div>
1576
1577                            </div>
1578
1579                            
1580                        </div>
1581                    </div>
1582                </div>
1583            </div>
1584        </div>
1585    </div>
1586</div>
1587</div>
1588<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1589    
1590
1591
1592
1593
1594
1595
1596<div class="modal_bg modalHide">
1597</div>
1598<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-7" data-cmp-data-layer="{&#34;redirect-7&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-7&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:10:27Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1599    <div class="u-container">
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1608                    
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1611                        
1612                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
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1630    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1631
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1633
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1637
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1671  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1672  &#34;xdm:linkType&#34; : &#34;external&#34;,
1673  &#34;xdm:linkURL&#34; : &#34;https://www.nordiqc.org/epitope.php?id=123&#34;,
1674  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1675  &#34;dc:title&#34; : &#34;Continue&#34;
1676}}" target="_blank" data-cmp-clickable>
1677					
1678					<span>Continue</span>
1679					
1680					
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1682				
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1685            
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1688		</li>
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1700  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
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1702  &#34;xdm:linkURL&#34; : &#34;#&#34;,
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1707							<span>Cancel</span>
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1722
1723    
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1727
1728                            </div>
1729
1730                            
1731                        </div>
1732                    </div>
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1735        </div>
1736    </div>
1737</div>
1738</div>
1739<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1740    
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1748</div>
1749<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-8" data-cmp-data-layer="{&#34;redirect-8&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-8&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:10:34Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1750    <div class="u-container">
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1755                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1756                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1757                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1758                    </div>
1759                    
1760                    
1761                    <div class="ast-margin__inline--sm">
1762                        
1763                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1764                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-8Heading">
1765                                <div class="text bottom-space-s bold-styling step-3">
1766<div data-cmp-data-layer="{&#34;text-86b5d36347&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-86b5d36347" class="cmp-text">
1767    <h2>Thank you for visiting</h2>
1768
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1772
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1774
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1777                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
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1779                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1780<div data-cmp-data-layer="{&#34;text-8de804f11d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-8de804f11d" class="cmp-text">
1781    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1782
1783</div>
1784
1785    
1786
1787</div>
1788
1789                            </div>
1790                        </div>
1791                        
1792                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1793
1794                            <div>
1795                                <div class="container responsivegrid">
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1800    
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1804    <div id="container-d5ffcef4ca" class="cmp-container">
1805    
1806    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1807	
1808    
1809
1810    
1811	<ul>
1812		<li>
1813			
1814			
1815			
1816			
1817
1818			
1819				
1820				
1821					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://portal.cancerdiagnosticeducation.com/" data-cmp-data-layer="{&#34;global-link-a94e20e84d-headerlink-item0null&#34;:{
1822  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1823  &#34;xdm:linkType&#34; : &#34;external&#34;,
1824  &#34;xdm:linkURL&#34; : &#34;https://portal.cancerdiagnosticeducation.com/&#34;,
1825  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1826  &#34;dc:title&#34; : &#34;Continue&#34;
1827}}" target="_blank" data-cmp-clickable>
1828					
1829					<span>Continue</span>
1830					
1831					
1832					</a>
1833				
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1835			
1836            
1837			
1838			
1839		</li>
1840	
1841		<li>
1842			
1843			
1844			
1845			
1846
1847			
1848				
1849					
1850						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-a94e20e84d-headerlink-item1null&#34;:{
1851  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
1852  &#34;xdm:linkType&#34; : &#34;internal&#34;,
1853  &#34;xdm:linkURL&#34; : &#34;#&#34;,
1854  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1855  &#34;dc:title&#34; : &#34;Cancel&#34;
1856}}" target="_self" data-cmp-clickable>
1857							
1858							<span>Cancel</span>
1859							 
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1861					
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1867            
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1869			
1870		</li>
1871	</ul>
1872</div>
1873
1874    
1875    </div>
1876
1877</div>
1878
1879                            </div>
1880
1881                            
1882                        </div>
1883                    </div>
1884                </div>
1885            </div>
1886        </div>
1887    </div>
1888</div>
1889</div>
1890<div class="gdsmodal aem-GridColumn aem-GridColumn--default--12">
1891    
1892
1893
1894
1895
1896
1897
1898<div class="modal_bg modalHide">
1899</div>
1900<div class="modal exitmodalpopup ast-padding__inline--0 modalHide previewModel " id="redirect-9" data-cmp-data-layer="{&#34;redirect-9&#34;:{&#34;enableDescription&#34;:true,&#34;enableButtons&#34;:true,&#34;enableTitle&#34;:true,&#34;xdm:linkURL&#34;:&#34;&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/gdsmodal/v1/gdsmodal&#34;,&#34;xdm:description&#34;:&#34;&#34;,&#34;id&#34;:&#34;redirect-9&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-21T17:23:56Z&#34;,&#34;enableReferencesList&#34;:false}}" data-backdrop="static" data-keyboard="false" tabindex="0" role="dialog" aria-modal="true" aria-label="Leave your website alert message box is opened">
1901    <div class="u-container">
1902         <div class="modal-dialog modal-dialog-centered ">
1903            <div class="modal-dialog" role="document">
1904                <div class="modal-content ast-information-card__container">
1905                    <div class="ast-card__top ast-color__bg--surface">
1906                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1907                        <div class="ast-color__bg--darkRed ast-card__top-rec"></div>
1908                        <div class="ast-color__bg--red ast-card__top-rec"></div>
1909                    </div>
1910                    
1911                    
1912                    <div class="ast-margin__inline--sm">
1913                        
1914                        <div class="modal-header justify-content-center border-bottom-0 ast-padding__inline--0">
1915                            <div class="modal-title ast__title-font ast__title--large ast-font__weight--bold ast-color__text--red" id="redirect-9Heading">
1916                                <div class="text bottom-space-s bold-styling step-3">
1917<div data-cmp-data-layer="{&#34;text-51a18d0dbc&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-08T20:16:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Thank you for visiting&lt;/h2>\r\n&#34;}}" id="text-51a18d0dbc" class="cmp-text">
1918    <h2>Thank you for visiting</h2>
1919
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1921
1922    
1923
1924</div>
1925
1926                            </div>
1927                        </div>
1928                        <div class="modal-body text-center border-bottom-0 ast-padding__top--xxs ast-padding__inline--0 ast-color__text--extraDarkGray">
1929                            <div class="ast__body-font ast__body--medium ast-color__text--extraDarkGray">
1930                                <div class="text bottom-space-xl text-styling step-1 cmp-weight-styles regular">
1931<div data-cmp-data-layer="{&#34;text-33faee1f27&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-11T14:46:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>By clicking &amp;quot;Continue,&amp;quot; you will leave this site.&lt;/p>\r\n&#34;}}" id="text-33faee1f27" class="cmp-text">
1932    <p>By clicking &#34;Continue,&#34; you will leave this site.</p>
1933
1934</div>
1935
1936    
1937
1938</div>
1939
1940                            </div>
1941                        </div>
1942                        
1943                        <div class="modal-footer border-top-0 justify-content-center ast-padding__inline--0">
1944
1945                            <div>
1946                                <div class="container responsivegrid">
1947
1948    
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1950    
1951    
1952    
1953    
1954
1955    <div id="container-c056932711" class="cmp-container">
1956    
1957    <div class="global-link cmp-global-link-primary cmp-horizantal-button">
1958	
1959    
1960
1961    
1962	<ul>
1963		<li>
1964			
1965			
1966			
1967			
1968
1969			
1970				
1971				
1972					<a href="javascript:void(0);" class="actionLinkRedirect" data-modal-link="https://www.astellas.com/en/about/privacy-center/privacy-policy.en-general-privacy-notice" data-cmp-data-layer="{&#34;global-link-6ef4516fdd-headerlink-item0null&#34;:{
1973  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
1974  &#34;xdm:linkType&#34; : &#34;external&#34;,
1975  &#34;xdm:linkURL&#34; : &#34;https://www.astellas.com/en/about/privacy-center/privacy-policy.en-general-privacy-notice&#34;,
1976  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
1977  &#34;dc:title&#34; : &#34;Continue&#34;
1978}}" target="_blank" data-cmp-clickable>
1979					
1980					<span>Continue</span>
1981					
1982					
1983					</a>
1984				
1985			
1986			
1987            
1988			
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1990		</li>
1991	
1992		<li>
1993			
1994			
1995			
1996			
1997
1998			
1999				
2000					
2001						<a href="javascript:void(0);" class="actionModalClose" data-modal-id="Cancel" data-modal-link="#" data-cmp-data-layer="{&#34;global-link-6ef4516fdd-headerlink-item1null&#34;:{
2002  &#34;xdm:linkTarget&#34; : &#34;_self&#34;,
2003  &#34;xdm:linkType&#34; : &#34;internal&#34;,
2004  &#34;xdm:linkURL&#34; : &#34;#&#34;,
2005  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
2006  &#34;dc:title&#34; : &#34;Cancel&#34;
2007}}" target="_self" data-cmp-clickable>
2008							
2009							<span>Cancel</span>
2010							 
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2017			
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2022	</ul>
2023</div>
2024
2025    
2026    </div>
2027
2028</div>
2029
2030                            </div>
2031
2032                            
2033                        </div>
2034                    </div>
2035                </div>
2036            </div>
2037        </div>
2038    </div>
2039</div>
2040</div>
2041
2042    
2043</div>
2044
2045    </div>
2046
2047    
2048</div>
2049</div>
2050
2051
2052    
2053</header>
2054<div class="container responsivegrid aem-GridColumn aem-GridColumn--default--12">
2055
2056    
2057    
2058    
2059    
2060    
2061    
2062
2063    <div id="container-838546b00f" class="cmp-container">
2064    
2065    <div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
2066<section style=";">
2067    
2068
2069    
2070    
2071    
2072    
2073    
2074    
2075
2076    <div id="container-24baee8fa9" class="cmp-container">
2077    
2078    <div class="hero3 bottom-space-s">
2079
2080
2081
2082<div class="cmp-teaser" id="hero3-667a9b983e" data-cmp-data-layer="{&#34;hero3-0e8cd78f48&#34;:{&#34;mediaType&#34;:&#34;Image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-02-25T12:53:53Z&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/heros/hero2/v1/hero2&#34;}}">
2083
2084   <div class="teasercontentblock cmp-teaser-content--variation1 cmp-teaser-content-block">
2085    
2086
2087
2088
2089
2090
2091
2092
2093<div class="cmp-teaser-content" id="teasercontentblock-cdc7d7f294">
2094  <div class="tagcallout text">
2095 <div class="cmp-tagcallout" id="tagcallout-9b67f7ded8" data-cmp-data-layer="{&#34;tagcallout-9b67f7ded8&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/tagcallout/v1/tagcallout&#34;,&#34;xdm:text&#34;:&#34;&#34;}}">
2096     <div class="text">
2097         <div class="cmp-text">
2098            
2099          </div>
2100      </div>
2101 </div>
2102
2103
2104    
2105</div>
2106
2107    
2108    <div class="text cmp-teaser-content--title">
2109         <div class="text bold-styling step-5 cmp-weight-styles bold cmp-element__colorcode--card-title">
2110<div data-cmp-data-layer="{&#34;text-ed27c790d2&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-05T17:52:07Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h1>Preparing and testing for CLDN18.2&lt;/h1>\r\n&#34;}}" id="text-ed27c790d2" class="cmp-text">
2111    <h1>Preparing and testing for CLDN18.2</h1>
2112
2113</div>
2114
2115    
2116
2117</div>
2118
2119		    
2120    </div>
2121	        
2122
2123    <div class="text cmp-teaser-content--description1">
2124
2125	        <div class="text bold-styling step-1 cmp-weight-styles semi-bold cmp-element__colorcode--primary-card-subtitle subtitle-styling">
2126<div data-cmp-data-layer="{&#34;text-72b70f300c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:04:17Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>&lt;span class=\&#34;cmp-weight-styles semi-bold bold-styling step-1\&#34;>Learn more about testing for CLDN18.2, including the impact of preanalytical factors on staining, the importance of antibody selection, and the significance of reflexive CLDN18.2 testing upon diagnosis.&lt;sup>1, 2&lt;/sup>&lt;/span>&lt;/h3>\r\n&#34;}}" id="text-72b70f300c" class="cmp-text">
2127    <h3><span class="cmp-weight-styles semi-bold bold-styling step-1">Learn more about testing for CLDN18.2, including the impact of preanalytical factors on staining, the importance of antibody selection, and the significance of reflexive CLDN18.2 testing upon diagnosis.<sup>1, 2</sup></span></h3>
2128
2129</div>
2130
2131    
2132
2133</div>
2134
2135		    
2136    </div>
2137    
2138    
2139    
2140
2141    
2142
2143    
2144
2145</div></div>
2146
2147
2148
2149
2150            <div class="cmp-hero-mediablock">
2151                <div class="image cmp-hero-mediablock--img">
2152                    <div class="cmp-image">
2153                        <div class="image rounded-corner cmp-desktop cmp-border-radius--s">
2154 
2155
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2246                                <a href="#why-ihc" target="_blank" data-cmp-clickable data-cmp-data-layer="{&#34;anchor-links-31936debfb-headerlink-item0null&#34;:{
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2253                                
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2255
2256                            </div>
2257                            
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2267
2268                                <a href="#preanalytics" target="_self" data-cmp-clickable data-cmp-data-layer="{&#34;anchor-links-31936debfb-headerlink-item1null&#34;:{
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2273  &#34;dc:title&#34; : &#34;Sample Preparation and Preanalytics&#34;
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2275                                
2276                                
2277
2278                            </div>
2279                            
2280						  
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2289
2290                                <a href="#ihc-testing" target="_self" data-cmp-clickable data-cmp-data-layer="{&#34;anchor-links-31936debfb-headerlink-item2null&#34;:{
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2295  &#34;dc:title&#34; : &#34;IHC Testing&#34;
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2297                                
2298                                
2299
2300                            </div>
2301                            
2302						  
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2306                    
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2312                                <a href="#proficiency-evaluations" target="_self" data-cmp-clickable data-cmp-data-layer="{&#34;anchor-links-31936debfb-headerlink-item3null&#34;:{
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2317  &#34;dc:title&#34; : &#34;Proficiency Evaluations&#34;
2318}}"><span>Proficiency Evaluations</span></a>
2319                                
2320                                
2321
2322                            </div>
2323                            
2324						  
2325                        </li>
2326                        
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2328                    
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2330						   
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2332                            <div class="cmp-nav__menu--icon">
2333
2334                                <a href="#reflexive-testing" target="_self" data-cmp-clickable data-cmp-data-layer="{&#34;anchor-links-31936debfb-headerlink-item4null&#34;:{
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2339  &#34;dc:title&#34; : &#34;Reflexive Testing&#34;
2340}}"><span>Reflexive Testing</span></a>
2341                                
2342                                
2343
2344                            </div>
2345                            
2346						  
2347                        </li>
2348                        
2349
2350                    </ul>
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2395</section></div>
2396<div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l">
2397<section style=";">
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2411		<div class="card teaser bottom-space-l card-secondary-dark cmp-teaser-content--dark">
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2421<input type="hidden" name="resourcePath" id="resourcePath" value="/content/claudin/hcp/north-america/us/en/prepare-and-test-samples"/>
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2428<!-- Card starts here -->
2429
2430<div class="cmp-teaser" id="why-ihc" data-cmp-data-layer="{&#34;why-ihc&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/card/v1/card&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-24T21:18:26Z&#34;}}" data-video-card="false" data-video-has-transcript="false" data-video-plain-transcript="false" data-cmp-typechecked="false" data-cmp-subtypechecked="false" data-cmp-channelchecked="false" data-cmp-seatavailabilitychecked="false" data-cmp-Datechecked="false" data-cmp-Jobcodechecked="false">
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2440            
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2445                    
2446                    
2447                        
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2453
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2455
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2459                        
2460                        
2461                        <!-- Time & Date from comp dialog-->
2462                        
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2464                        
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2466                        
2467                        <!--description-->
2468                        
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2470
2471                    <div class="text bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
2472<div data-cmp-data-layer="{&#34;text-e02d55b9cb&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-11T15:25:41Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>&lt;b>IHC testing is the only clinically validated method to detect CLDN18.2 expression in G/GEJ adenocarcinoma.&lt;sup>1-3&lt;/sup> Other methods, including whole-transcriptome sequencing and liquid biopsy, while useful in other contexts, cannot directly evaluate protein expression or localization and are not suitable for assessing CLDN18.2 positivity in clinical practice.&lt;sup>4,5&lt;/sup>&lt;/b>&lt;/h2>\n&#34;}}" id="text-e02d55b9cb" class="cmp-text">
2473    <h2><b>IHC testing is the only clinically validated method to detect CLDN18.2 expression in G/GEJ adenocarcinoma.<sup>1-3</sup> Other methods, including whole-transcriptome sequencing and liquid biopsy, while useful in other contexts, cannot directly evaluate protein expression or localization and are not suitable for assessing CLDN18.2 positivity in clinical practice.<sup>4,5</sup></b></h2>
2474
2475</div>
2476
2477    
2478
2479</div>
2480
2481
2482                    
2483                    
2484                    <!-- Container -->
2485                    
2486                </div>
2487                <!-- Global Link Component-->
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2489            </div>
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2491        <!-- Card Reference Component-->
2492        
2493    
2494</div></div>
2495
2496		
2497		
2498	</div>
2499</div>
2500<div class="text bottom-space-m bold-styling step-4 cmp-weight-styles bold cmp-element__colorcode--page-title">
2501<div data-cmp-data-layer="{&#34;text-29439a6058&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-05-12T20:20:27Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>IHC testing: Using CLDN18 antibodies to detect CLDN18.2 in G/GEJ tumor samples&lt;/h2>&#34;}}" id="text-29439a6058" class="cmp-text">
2502    <h2>IHC testing: Using CLDN18 antibodies to detect CLDN18.2 in G/GEJ tumor samples</h2>
2503</div>
2504
2505    
2506
2507</div>
2508<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2509<div data-cmp-data-layer="{&#34;text-364953f0f2&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:20:39Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>CLDN18 antibodies can identify both CLDN18 isoforms—CLDN18.1 and CLDN18.2; however, when evaluating G/GEJ tumor tissue, &lt;span class=\&#34;cmp-weight-styles bold\&#34;>staining can be attributed to the presence of CLDN18.2 only, because&lt;sup>3&lt;/sup>:&lt;/span>&lt;/p>&#34;}}" id="text-364953f0f2" class="cmp-text">
2510    <p>CLDN18 antibodies can identify both CLDN18 isoforms—CLDN18.1 and CLDN18.2; however, when evaluating G/GEJ tumor tissue, <span class="cmp-weight-styles bold">staining can be attributed to the presence of CLDN18.2 only, because<sup>3</sup>:</span></p>
2511</div>
2512
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2514
2515</div>
2516<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2517<div data-cmp-data-layer="{&#34;text-a0792b557b&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:21:05Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>CLDN18.1 is the dominant isoform expressed in normal and malignant lung tissue, and its expression is negligible or absent in G/GEJ cancers&lt;sup>3&lt;/sup>&lt;/li>\n&lt;li>CLDN18.2 is normally expressed in gastric epithelium, and expression is often &lt;span class=\&#34;cmp-weight-styles bold\&#34;>retained in malignant gastric tissue&lt;/span>&lt;sup>3&lt;/sup>&lt;/li>\n&lt;/ul>&#34;}}" id="text-a0792b557b" class="cmp-text">
2518    <ul><li>CLDN18.1 is the dominant isoform expressed in normal and malignant lung tissue, and its expression is negligible or absent in G/GEJ cancers<sup>3</sup></li><li>CLDN18.2 is normally expressed in gastric epithelium, and expression is often <span class="cmp-weight-styles bold">retained in malignant gastric tissue</span><sup>3</sup></li></ul>
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2552    <div id="container-273f554061" class="cmp-container">
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2554    <div class="text bottom-space-m bold-styling step-4 cmp-weight-styles bold cmp-element__colorcode--page-title">
2555<div data-cmp-data-layer="{&#34;preanalytics&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-24T21:14:06Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Sample preparation and preanalytics&lt;/h2>\r\n&#34;}}" id="preanalytics" class="cmp-text">
2556    <h2>Sample preparation and preanalytics</h2>
2557
2558</div>
2559
2560    
2561
2562</div>
2563<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2564<div data-cmp-data-layer="{&#34;text-961239e51c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-05T13:38:04Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Appropriate specimen handling and preparation are essential to ensure the accuracy of biomarker results.&lt;sup>1&lt;/sup>&lt;/p>\r\n&#34;}}" id="text-961239e51c" class="cmp-text">
2565    <p>Appropriate specimen handling and preparation are essential to ensure the accuracy of biomarker results.<sup>1</sup></p>
2566
2567</div>
2568
2569    
2570
2571</div>
2572<div class="text bottom-space-xs bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2573<div data-cmp-data-layer="{&#34;text-87a304db6f&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T14:40:26Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Sample preparation&lt;/h2>\r\n&#34;}}" id="text-87a304db6f" class="cmp-text">
2574    <h2>Sample preparation</h2>
2575
2576</div>
2577
2578    
2579
2580</div>
2581<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2582<div data-cmp-data-layer="{&#34;text-a125ff3fde&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T14:41:17Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Guidelines recommend daily tissue processor maintenance per the manufacturer recommendations and rigorous quality maintenance of processor fluids, including formalin pH/purity and water contamination of alcohols.&lt;sup>1&lt;/sup>&lt;/p>\r\n&#34;}}" id="text-a125ff3fde" class="cmp-text">
2583    <p>Guidelines recommend daily tissue processor maintenance per the manufacturer recommendations and rigorous quality maintenance of processor fluids, including formalin pH/purity and water contamination of alcohols.<sup>1</sup></p>
2584
2585</div>
2586
2587    
2588
2589</div>
2590<div class="separator bottom-space-s top-space-s cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-f9ff730af6" class="cmp-separator">
2591    <hr class="cmp-separator__horizontal-rule"/>
2592</div>
2593</div>
2594<div class="text bottom-space-xs top-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2595<div data-cmp-data-layer="{&#34;text-7fcf71e970&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T15:10:27Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Cold ischemic time&lt;/h2>\r\n&#34;}}" id="text-7fcf71e970" class="cmp-text">
2596    <h2>Cold ischemic time</h2>
2597
2598</div>
2599
2600    
2601
2602</div>
2603<div class="text text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2604<div data-cmp-data-layer="{&#34;text-dba7b18b2b&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-16T19:24:05Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Cold ischemic time should be limited to ≤60 minutes according to current guidelines.&lt;sup>1&lt;/sup>&lt;/p>\r\n&#34;}}" id="text-dba7b18b2b" class="cmp-text">
2605    <p>Cold ischemic time should be limited to ≤60 minutes according to current guidelines.<sup>1</sup></p>
2606
2607</div>
2608
2609    
2610
2611</div>
2612<div class="separator bottom-space-xl top-space-xl cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-12aa171ac9" class="cmp-separator">
2613    <hr class="cmp-separator__horizontal-rule"/>
2614</div>
2615</div>
2616<div class="text bottom-space-xs bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2617<div data-cmp-data-layer="{&#34;text-d60df238ea&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-16T19:24:14Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Fixation&lt;/h2>\r\n&#34;}}" id="text-d60df238ea" class="cmp-text">
2618    <h2>Fixation</h2>
2619
2620</div>
2621
2622    
2623
2624</div>
2625<div class="text text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2626<div data-cmp-data-layer="{&#34;text-60d7bd61e2&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-12T21:27:39Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Guidelines provide recommendations regarding dimensions and duration involved in sample fixation.&lt;sup>1&lt;/sup>&lt;/p>\r\n&#34;}}" id="text-60d7bd61e2" class="cmp-text">
2627    <p>Guidelines provide recommendations regarding dimensions and duration involved in sample fixation.<sup>1</sup></p>
2628
2629</div>
2630
2631    
2632
2633</div>
2634<div class="columncontainer responsivegrid">
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2667        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&ts=1790348524882&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=400&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=600&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=800&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=1000&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=1200&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=1400&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=1800&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-ruler-d?qlt=82&amp;wid=2000&amp;ts=1790348524882&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="528" height="528" alt/>
2668    
2669    
2670</div>
2671
2672    
2673
2674
2675
2676
2677     <!-- Code embed Component-->
2678</div>
2679
2680<div class="illustration-container__content" id="illustration-container-9dc3b1df51" data-cmp-data-layer="{&#34;illustration-container-9dc3b1df51&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/illustration-container/v1/illustration-container&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:31:29Z&#34;,&#34;dc:title&#34;:&#34;&lt;h4>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>Key dimensions&lt;sup>1&lt;/sup>&lt;/span>&lt;/h4>\r\n&#34;,&#34;dc:description&#34;:&#34;&lt;ul>&lt;li>Tissue should be completely submerged in fixative&lt;/li>&lt;li>Ensure a fixative volume-to-tissue mass ratio of no less than 4:1, with an optimal ratio of 10:1&lt;/li>&lt;/ul>\r\n&#34;}}">
2681   
2682   
2683      
2684   
2685   <!--jobcode-->
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2687   <!--kicker-->
2688   
2689   
2690   <div class="illustration-container__content--title " aria-label="&lt;h4>&lt;span class=&#34;cmp-weight-styles bold&#34;>Key dimensions&lt;sup>1&lt;/sup>&lt;/span>&lt;/h4>
2691"><span><h4><span class="cmp-weight-styles bold">Key dimensions<sup>1</sup></span></h4>
2692</span></div>
2693   
2694    
2695   <!-- Time & Date from comp dialog-->
2696      
2697   <!-- Time & Date from page Properties-->
2698      
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2700      <div class="illustration-container__content--description ">
2701         <p><ul><li>Tissue should be completely submerged in fixative</li><li>Ensure a fixative volume-to-tissue mass ratio of no less than 4:1, with an optimal ratio of 10:1</li></ul>
2702</p>
2703      </div>
2704   
2705    
2706    
2707   
2708   <!-- Card Reference Component-->
2709   
2710</div></div>
2711
2712		
2713		
2714		
2715	</div>
2716</div>
2717
2718    
2719</div>
2720</div>
2721        
2722            
2723            <div class="cmp-columncontainer-item">
2724
2725
2726<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
2727    
2728    <div class="illustrationset aem-GridColumn aem-GridColumn--default--12">
2729    
2730
2731
2732	<div class="cmp-illustration" data-cmp-data-layer="{&#34;illustrationset-a14e9de25a&#34;:{&#34;dc:description&#34;:&#34;&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T15:15:44Z&#34;,&#34;xdm:linkURL&#34;:&#34;/content/claudin/hcp/north-america/us/en/prepare-and-test-samples&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/illustrationset/v1/illustrationset&#34;,&#34;dc:title&#34;:&#34;&#34;}}">
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2735
2736
2737
2738
2739
2740
2741
2742<div class="illustration-container__imgwrapper">
2743
2744   
2745    
2746 
2747
2748<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off" data-asset-id="a1ee6f0e-b77a-4d38-8f21-dbca52b711bd" id="illustration-container-ae99000cdc-image" data-cmp-data-layer="{&#34;illustration-container-ae99000cdc-image&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:31:39Z&#34;,&#34;xdm:linkURL&#34;:&#34;/prepare-and-test-samples&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;a1ee6f0e-b77a-4d38-8f21-dbca52b711bd&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:00Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-icon-clock-d.png&#34;}}}" data-cmp-hook-image="imageV5" class="cmp-image" itemscope itemtype="http://schema.org/ImageObject">
2749        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&ts=1790348520123&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=400&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=600&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=800&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=1000&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=1200&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=1400&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=1800&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-icon-clock-d?qlt=82&amp;wid=2000&amp;ts=1790348520123&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="528" height="528" alt/>
2750    
2751    
2752</div>
2753
2754    
2755
2756
2757
2758
2759     <!-- Code embed Component-->
2760</div>
2761
2762<div class="illustration-container__content" id="illustration-container-ae99000cdc" data-cmp-data-layer="{&#34;illustration-container-ae99000cdc&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/illustration-container/v1/illustration-container&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:31:39Z&#34;,&#34;dc:title&#34;:&#34;&lt;h4>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>Key durations&lt;sup>1&lt;/sup>&lt;/span>&lt;/h4>\r\n&#34;,&#34;dc:description&#34;:&#34;&lt;ul>&lt;li>As part of stabilization, tissue should be fixed in 10% neutral phosphate-buffered formalin (pH 7.0) for at least 6 hours and no longer than 24 to 36 hours&lt;/li>&lt;li>If the tissue has high fat content, fixation may require up to 48 hours&lt;/li>&lt;/ul>\r\n&#34;}}">
2763   
2764   
2765      
2766   
2767   <!--jobcode-->
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2769   <!--kicker-->
2770   
2771   
2772   <div class="illustration-container__content--title " aria-label="&lt;h4>&lt;span class=&#34;cmp-weight-styles bold&#34;>Key durations&lt;sup>1&lt;/sup>&lt;/span>&lt;/h4>
2773"><span><h4><span class="cmp-weight-styles bold">Key durations<sup>1</sup></span></h4>
2774</span></div>
2775   
2776    
2777   <!-- Time & Date from comp dialog-->
2778      
2779   <!-- Time & Date from page Properties-->
2780      
2781   
2782      <div class="illustration-container__content--description ">
2783         <p><ul><li>As part of stabilization, tissue should be fixed in 10% neutral phosphate-buffered formalin (pH 7.0) for at least 6 hours and no longer than 24 to 36 hours</li><li>If the tissue has high fat content, fixation may require up to 48 hours</li></ul>
2784</p>
2785      </div>
2786   
2787    
2788    
2789   
2790   <!-- Card Reference Component-->
2791   
2792</div></div>
2793
2794		
2795		
2796		
2797	</div>
2798</div>
2799
2800    
2801</div>
2802</div>
2803        
2804    </div>
2805</div>
2806<div class="separator bottom-space-xl top-space-xl cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-a96d50e97a" class="cmp-separator">
2807    <hr class="cmp-separator__horizontal-rule"/>
2808</div>
2809</div>
2810<div class="text bottom-space-xs bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2811<div data-cmp-data-layer="{&#34;text-931de74943&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-15T16:56:06Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Specimen preparation&lt;sup>1,2&lt;/sup>&lt;/h2>\n&#34;}}" id="text-931de74943" class="cmp-text">
2812    <h2>Specimen preparation<sup>1,2</sup></h2>
2813
2814</div>
2815
2816    
2817
2818</div>
2819<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2820<div data-cmp-data-layer="{&#34;text-e8537dad5d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-01T21:29:47Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>Routinely processed, formalin-fixed, paraffin-embedded (FFPE) tissues are suitable for use with IHC testing&lt;ul>\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Low-melt paraffin should be melted at &amp;lt;60 °C&lt;/li>\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Specimen should contain sufficient tumor tissue for analysis&lt;/li>\n&lt;/ul>\n&lt;/li>\n&lt;li>Specimens that are fine-needle aspirate (FNA), cytology specimens, or metastatic bone lesion do not qualify for CLDN18 staining&lt;/li>\n&lt;li>Tissue sections should be cut at ~4 μm thick with a range from 3 μm to 5 μm*&lt;/li>\n&lt;li>It is recommended that slides are stained immediately, as antigenicity of cut tissue sections may diminish over time&lt;/li>\n&lt;/ul>\n&#34;}}" id="text-e8537dad5d" class="cmp-text">
2821    <ul><li>Routinely processed, formalin-fixed, paraffin-embedded (FFPE) tissues are suitable for use with IHC testing<ul><li style="	list-style-type: disc;
2822">Low-melt paraffin should be melted at &lt;60 °C</li><li style="	list-style-type: disc;
2823">Specimen should contain sufficient tumor tissue for analysis</li></ul>
2824</li><li>Specimens that are fine-needle aspirate (FNA), cytology specimens, or metastatic bone lesion do not qualify for CLDN18 staining</li><li>Tissue sections should be cut at ~4 μm thick with a range from 3 μm to 5 μm*</li><li>It is recommended that slides are stained immediately, as antigenicity of cut tissue sections may diminish over time</li></ul>
2825
2826</div>
2827
2828    
2829
2830</div>
2831<div class="text text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2832<div data-cmp-data-layer="{&#34;text-dc8df46a90&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-16T19:27:27Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>*CLDN18-specific.&lt;/p>\r\n&#34;}}" id="text-dc8df46a90" class="cmp-text">
2833    <p>*CLDN18-specific.</p>
2834
2835</div>
2836
2837    
2838
2839</div>
2840<div class="separator bottom-space-xl top-space-xl cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-e03d289548" class="cmp-separator">
2841    <hr class="cmp-separator__horizontal-rule"/>
2842</div>
2843</div>
2844<div class="text bottom-space-s bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2845<div data-cmp-data-layer="{&#34;text-bd570617b0&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:37:46Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Storage conditions&lt;sup>2,6&lt;/sup>&lt;/h2>&#34;}}" id="text-bd570617b0" class="cmp-text">
2846    <h2>Storage conditions<sup>2,6</sup></h2>
2847</div>
2848
2849    
2850
2851</div>
2852<div class="text bottom-space-xs text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2853<div data-cmp-data-layer="{&#34;text-acbb899e1c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T16:39:20Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Cut slides/FFPE tissue should be:&lt;/p>\r\n&#34;}}" id="text-acbb899e1c" class="cmp-text">
2854    <p>Cut slides/FFPE tissue should be:</p>
2855
2856</div>
2857
2858    
2859
2860</div>
2861<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2862<div data-cmp-data-layer="{&#34;text-94b0c8d20f&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T16:43:56Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\r\n&lt;li>Desiccated&lt;/li>\r\n&lt;li>Stored at room temperature&lt;/li>\r\n&lt;li>Stored out of direct sunlight&lt;/li>\r\n&lt;li>Kept away from an open flame or direct heat source&lt;/li>\r\n&lt;/ul>\r\n&#34;}}" id="text-94b0c8d20f" class="cmp-text">
2863    <ul><li>Desiccated</li><li>Stored at room temperature</li><li>Stored out of direct sunlight</li><li>Kept away from an open flame or direct heat source</li></ul>
2864
2865</div>
2866
2867    
2868
2869</div>
2870<div class="text bottom-space-xs text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--primary-page-subtitle">
2871<div data-cmp-data-layer="{&#34;text-7457ece7c0&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T16:45:34Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Environmental factors affect antigen stability, and antigenicity decreases over time; therefore:&lt;/p>&#34;}}" id="text-7457ece7c0" class="cmp-text">
2872    <p>Environmental factors affect antigen stability, and antigenicity decreases over time; therefore:</p>
2873</div>
2874
2875    
2876
2877</div>
2878<div class="text text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2879<div data-cmp-data-layer="{&#34;text-434cce1e04&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-16T19:34:13Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>The VENTANA method sheet (package insert) recommends that laboratories validate cut slide stability within their own environment beyond 45 days&lt;/li>\n&lt;li>Discovery Life Sciences recommends using slides within one calendar month from the date of sectioning&lt;/li>\n&lt;/ul>&#34;}}" id="text-434cce1e04" class="cmp-text">
2880    <ul><li>The VENTANA method sheet (package insert) recommends that laboratories validate cut slide stability within their own environment beyond 45 days</li><li>Discovery Life Sciences recommends using slides within one calendar month from the date of sectioning</li></ul>
2881</div>
2882
2883    
2884
2885</div>
2886<div class="separator bottom-space-xl top-space-xl cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-b98cf07df8" class="cmp-separator">
2887    <hr class="cmp-separator__horizontal-rule"/>
2888</div>
2889</div>
2890<div class="text bottom-space-2xs bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--primary-page-subtitle">
2891<div data-cmp-data-layer="{&#34;text-c215ad669c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-20T16:00:03Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Suboptimal tissue fixation&lt;sup>1&lt;/sup>&lt;/h3>\r\n&#34;}}" id="text-c215ad669c" class="cmp-text">
2892    <h3>Suboptimal tissue fixation<sup>1</sup></h3>
2893
2894</div>
2895
2896    
2897
2898</div>
2899<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2900<div data-cmp-data-layer="{&#34;text-84fa1c9378&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-13T14:18:39Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>It is important to optimize preanalytical variables to minimize staining artifacts.&lt;/p>\r\n&#34;}}" id="text-84fa1c9378" class="cmp-text">
2901    <p>It is important to optimize preanalytical variables to minimize staining artifacts.</p>
2902
2903</div>
2904
2905    
2906
2907</div>
2908<div class="image bottom-space-s">
2909 
2910
2911<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348524631&amp;dpr=off" data-asset-id="70dac984-84fb-4fcd-8551-9fc2f425b20d" id="image-b258000ae1" data-cmp-data-layer="{&#34;image-b258000ae1&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:32:04Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;70dac984-84fb-4fcd-8551-9fc2f425b20d&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:04Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
2912    
2913        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&ts=1790348524631&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=400&amp;ts=1790348524631&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=600&amp;ts=1790348524631&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=800&amp;ts=1790348524631&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=1000&amp;ts=1790348524631&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=1200&amp;ts=1790348524631&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=1400&amp;ts=1790348524631&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=1800&amp;ts=1790348524631&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-clyptophasmic-d?qlt=82&amp;wid=2000&amp;ts=1790348524631&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="5104" height="2868" alt="Cytoplasmic blushing due to suboptimal fixation"/>
2914    
2915    
2916    
2917</div>
2918
2919    
2920
2921</div>
2922<div class="text bottom-space-m bold-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
2923<div data-cmp-data-layer="{&#34;text-da28576f09&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T17:56:13Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p style=\&#34;text-align: center;\&#34;>Suboptimal tissue fixation can cause cytoplasmic blushing and interfere with accurate membranous scoring.&lt;/p>\r\n&#34;}}" id="text-da28576f09" class="cmp-text">
2924    <p style="	text-align: center;
2925">Suboptimal tissue fixation can cause cytoplasmic blushing and interfere with accurate membranous scoring.</p>
2926
2927</div>
2928
2929    
2930
2931</div>
2932
2933    
2934    </div>
2935
2936
2937</section></div>
2938
2939    
2940    </div>
2941
2942</div>
2943<div class="container responsivegrid">
2944
2945    
2946    
2947    
2948    
2949    
2950    
2951
2952    <div id="container-9b5239d917" class="cmp-container" style="background:#35373c;">
2953    
2954    <div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
2955<section style=";">
2956    
2957
2958    
2959    
2960    
2961    
2962    
2963    
2964
2965    <div id="container-1be9dc9fd4" class="cmp-container">
2966    
2967    <div class="text bottom-space-m bold-styling step-4 cmp-weight-styles bold cmp-element__colorcode--white-500">
2968<div data-cmp-data-layer="{&#34;ihc-testing&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-24T21:19:53Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Testing&lt;/h2>\r\n&#34;}}" id="ihc-testing" class="cmp-text">
2969    <h2>Testing</h2>
2970
2971</div>
2972
2973    
2974
2975</div>
2976<div class="text bottom-space-xs bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
2977<div data-cmp-data-layer="{&#34;text-ac0f53538d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-07T19:20:30Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Antibody options for evaluating CLDN18.2 expression via IHC&lt;sup>2,7,8&lt;/sup>&lt;/h3>\n&#34;}}" id="text-ac0f53538d" class="cmp-text">
2978    <h3>Antibody options for evaluating CLDN18.2 expression via IHC<sup>2,7,8</sup></h3>
2979
2980</div>
2981
2982    
2983
2984</div>
2985<div class="text bottom-space-l text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
2986<div data-cmp-data-layer="{&#34;text-9cf3f86895&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-06T18:37:20Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>A number of assays and antibodies are available to assess CLDN18.2 expression. The list below is not exhaustive. An appropriate, validated IHC antibody/assay with high performance should be used when guiding clinical decision-making.&lt;/p>\r\n&#34;}}" id="text-9cf3f86895" class="cmp-text">
2987    <p>A number of assays and antibodies are available to assess CLDN18.2 expression. The list below is not exhaustive. An appropriate, validated IHC antibody/assay with high performance should be used when guiding clinical decision-making.</p>
2988
2989</div>
2990
2991    
2992
2993</div>
2994<div class="image rounded-corner cmp-mobile">
2995 
2996
2997<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off" data-asset-id="be39315a-1e6e-4abb-99e1-037eac74ac9c" id="image-92d7eaea83" data-cmp-data-layer="{&#34;image-92d7eaea83&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:32:35Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;be39315a-1e6e-4abb-99e1-037eac74ac9c&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:00Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-table-testing-m.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
2998    
2999        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&ts=1790348520289&$transperant$&wid=400&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=400&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=600&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=800&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=1000&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=1200&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=1400&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=1800&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-m?qlt=82&amp;wid=2000&amp;ts=1790348520289&amp;$transperant$&amp;wid=400&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="1324" height="883" alt/>
3000    
3001    
3002    
3003</div>
3004
3005    
3006
3007</div>
3008<div class="image rounded-corner cmp-desktop cmp-border-radius--s">
3009 
3010
3011<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off" data-asset-id="366e8ff8-c6dc-4441-8ff0-b749bac72e6f" id="image-603bc95b8a" data-cmp-data-layer="{&#34;image-603bc95b8a&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:32:28Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;366e8ff8-c6dc-4441-8ff0-b749bac72e6f&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:06Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-table-testing-d.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
3012    
3013        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&ts=1790348526250&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=400&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=600&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=800&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=1000&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=1200&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=1400&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=1800&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-table-testing-d?qlt=82&amp;wid=2000&amp;ts=1790348526250&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="5104" height="3403" alt/>
3014    
3015    
3016    
3017</div>
3018
3019    
3020
3021</div>
3022
3023    
3024    </div>
3025
3026
3027</section></div>
3028
3029    
3030    </div>
3031
3032</div>
3033<div class="container responsivegrid">
3034
3035    
3036    
3037    
3038    
3039    
3040    
3041
3042    <div id="container-e72b65d720" class="cmp-container" style="background:#5D5F63;">
3043    
3044    <div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
3045<section style=";">
3046    
3047
3048    
3049    
3050    
3051    
3052    
3053    
3054
3055    <div id="container-b7b7e16a6a" class="cmp-container">
3056    
3057    <div class="text bottom-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
3058<div data-cmp-data-layer="{&#34;text-b73bf99309&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-13T14:43:14Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Select appropriate controls&lt;/h2>\r\n&#34;}}" id="text-b73bf99309" class="cmp-text">
3059    <h2>Select appropriate controls</h2>
3060
3061</div>
3062
3063    
3064
3065</div>
3066<div class="text bottom-space-l text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3067<div data-cmp-data-layer="{&#34;text-d90fa5d2a8&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:51:25Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Appropriate controls are essential for the detection of CLDN18.2 in G/GEJ tumor samples. Here are some key points on their selection and use.&lt;sup>2,9&lt;/sup>&lt;/p>&#34;}}" id="text-d90fa5d2a8" class="cmp-text">
3068    <p>Appropriate controls are essential for the detection of CLDN18.2 in G/GEJ tumor samples. Here are some key points on their selection and use.<sup>2,9</sup></p>
3069</div>
3070
3071    
3072
3073</div>
3074<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3075<div data-cmp-data-layer="{&#34;text-07b1fffd6d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-13T14:48:11Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Validation controls&lt;/h3>\r\n&#34;}}" id="text-07b1fffd6d" class="cmp-text">
3076    <h3>Validation controls</h3>
3077
3078</div>
3079
3080    
3081
3082</div>
3083<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3084<div data-cmp-data-layer="{&#34;text-62f963d82e&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:51:37Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Guidelines recommend that laboratories validate and/or verify immunohistochemical tests before placing them into clinical service. The
3084se tests should include positive, negative, and borderline tissue, reflecting the intended use of the assay.&lt;sup>10&lt;/sup>&lt;/p>&#34;}}" id="text-62f963d82e" class="cmp-text">
3085    <p>Guidelines recommend that laboratories validate and/or verify immunohistochemical tests before placing them into clinical service. These tests should include positive, negative, and borderline tissue, reflecting the intended use of the assay.<sup>10</sup></p>
3086</div>
3087
3088    
3089
3090</div>
3091<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3092<div data-cmp-data-layer="{&#34;text-197d946559&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-28T17:37:49Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Tissue controls are commercially available through various providers.&lt;/p>\r\n&#34;}}" id="text-197d946559" class="cmp-text">
3093    <p>Tissue controls are commercially available through various providers.</p>
3094
3095</div>
3096
3097    
3098
3099</div>
3100<div class="global-link cmp-global-link-primary step-0">
3101	
3102    
3103
3104    
3105	<ul>
3106		<li>
3107			
3108			
3109			
3110			
3111
3112			
3113				
3114				
3115					<a href="javascript:void(0);" class="actionModalOpen" data-modal-id="redirect-1" data-modal-link="https://dls.com/cldn182/" data-cmp-data-layer="{&#34;global-link-9863e80404-headerlink-item0null&#34;:{
3116  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
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3118  &#34;xdm:linkURL&#34; : &#34;https://dls.com/cldn182/&#34;,
3119  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
3120  &#34;dc:title&#34; : &#34;Learn More&#34;
3121}}" target="_blank" data-cmp-clickable>
3122					
3123					<span>Learn More</span>
3124					
3125					
3126					</a>
3127				
3128			
3129			
3130            
3131			
3132			
3133		</li>
3134	</ul>
3135</div>
3136<div class="separator bottom-space-xl top-space-xl cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-43d53a4381" class="cmp-separator">
3137    <hr class="cmp-separator__horizontal-rule"/>
3138</div>
3139</div>
3140<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3141<div data-cmp-data-layer="{&#34;text-137a2cccbd&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-16T19:45:23Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Run controls&lt;sup>2&lt;/sup>&lt;/h3>\r\n&#34;}}" id="text-137a2cccbd" class="cmp-text">
3142    <h3>Run controls<sup>2</sup></h3>
3143
3144</div>
3145
3146    
3147
3148</div>
3149<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3150<div data-cmp-data-layer="{&#34;text-e3bed2ad2c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-19T21:17:16Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>It is recommended to use optimal run controls, including positives and negatives&lt;/li>\n&lt;li>Gastric intestinal metaplasia tissue is an example of an appropriate positive and negative control as it demonstrates&lt;ul>\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Strong membranous staining in normal gastric epithelial cells&lt;/li>\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Weak-to-moderate membranous staining of epithelial cells in areas of metaplasia&lt;/li>\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Absence of staining in lamina propria, lymphocytes, smooth muscle, blood vessels, and peripheral nerve&lt;/li>\n&lt;/ul>\n&lt;/li>\n&lt;li>If the positive controls fail to demonstrate staining, results of the test specimen should be considered invali
3150d&lt;/li>\n&lt;li>Known positive tissue controls should be utilized only for monitoring performance of reagents and instruments, not as an aid in determining the specific diagnosis of test samples&lt;/li>\n&lt;/ul>\n&#34;}}" id="text-e3bed2ad2c" class="cmp-text">
3151    <ul><li>It is recommended to use optimal run controls, including positives and negatives</li><li>Gastric intestinal metaplasia tissue is an example of an appropriate positive and negative control as it demonstrates<ul><li style="	list-style-type: disc;
3152">Strong membranous staining in normal gastric epithelial cells</li><li style="	list-style-type: disc;
3153">Weak-to-moderate membranous staining of epithelial cells in areas of metaplasia</li><li style="	list-style-type: disc;
3154">Absence of staining in lamina propria, lymphocytes, smooth muscle, blood vessels, and peripheral nerve</li></ul>
3155</li><li>If the positive controls fail to demonstrate staining, results of the test specimen should be considered invalid</li><li>Known positive tissue controls should be utilized only for monitoring performance of reagents and instruments, not as an aid in determining the specific diagnosis of test samples</li></ul>
3156
3157</div>
3158
3159    
3160
3161</div>
3162
3163    
3164    </div>
3165
3166
3167</section></div>
3168
3169    
3170    </div>
3171
3172</div>
3173<div class="container responsivegrid">
3174
3175    
3176    
3177    
3178    
3179    
3180    
3181
3182    <div id="container-d781ef11de" class="cmp-container" style="background:#35373C;">
3183    
3184    <div class="section-container container responsivegrid cmp-full-width-section top-padding-l bottom-padding-m">
3185<section style=";">
3186    
3187
3188    
3189    
3190    
3191    
3192    
3193    
3194
3195    <div id="container-61ed121959" class="cmp-container">
3196    
3197    <div class="text bottom-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
3198<div data-cmp-data-layer="{&#34;text-f93dbdc018&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:52:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Considerations for laboratory-developed tests (LDTs)&lt;sup>11&lt;/sup>&lt;/h2>&#34;}}" id="text-f93dbdc018" class="cmp-text">
3199    <h2>Considerations for laboratory-developed tests (LDTs)<sup>11</sup></h2>
3200</div>
3201
3202    
3203
3204</div>
3205<div class="text bottom-space-l text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3206<div data-cmp-data-layer="{&#34;text-4680c62e49&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-29T18:54:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Companion diagnostic (CDx) assays are clinically validated and approved for use with specific therapies and indications;&lt;br />\r\nhowever, clinical laboratories may opt to use LDTs instead of a CDx assay due to limited resources or lack of access.&lt;/p>\r\n&#34;}}" id="text-4680c62e49" class="cmp-text">
3207    <p>Companion diagnostic (CDx) assays are clinically validated and approved for use with specific therapies and indications;<br />
3208however, clinical laboratories may opt to use LDTs instead of a CDx assay due to limited resources or lack of access.</p>
3209
3210</div>
3211
3212    
3213
3214</div>
3215<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3216<div data-cmp-data-layer="{&#34;text-f208884adc&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-26T21:11:53Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>CAP Guidelines for the use of LDTs include the following:&lt;/h3>\r\n&#34;}}" id="text-f208884adc" class="cmp-text">
3217    <h3>CAP Guidelines for the use of LDTs include the following:</h3>
3218
3219</div>
3220
3221    
3222
3223</div>
3224<div class="text bottom-space-l text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3225<div data-cmp-data-layer="{&#34;text-de09e8af7b&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-11T15:27:06Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>Laboratories must analytically validate all LDTs before reporting results on patient tissues&lt;/li>\n&lt;li>For initial analytic validation or verification of every assay used clinically, laboratories should achieve at least 90% overall concordance
between the new assay and the comparator assay or expected results&lt;/li>\n&lt;li>For initial analytic validation of all predictive LDTs, laboratories should test a minimum of 20 positive and 20 negative tissues&lt;/li>\n&lt;li>Laboratories should use validation tissues that have been processed using the same fixative and processing methods as cases that will be tested clinically, when possible&lt;/li>\n&lt;/ul>\n&#34;}}" id="text-de09e8af7b" class="cmp-text">
3226    <ul><li>Laboratories must analytically validate all LDTs before reporting results on patient tissues</li><li>For initial analytic validation or verification of every assay used clinically, laboratories should achieve at least 90% overall concordance
between the new assay and the comparator assay or expected results</li><li>For initial analytic validation of all predictive LDTs, laboratories should test a minimum of 20 positive and 20 negative tissues</li><li>Laboratories should use validation tissues that have been processed using the same fixative and processing methods as cases that will be tested clinically, when possible</li></ul>
3227
3228</div>
3229
3230    
3231
3232</div>
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3253
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3255    <!-- image text  -->
3256
3257    
3258
3259
3260
3261    
3262        <!-- Load when carousel link is not enabled -->
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3269                    
3270                    
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3278                    
3279
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3283                        
3284                        
3285                        <!-- Time & Date from comp dialog-->
3286                        
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3292                        
3293                    </div>
3294
3295                    <div class="text bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3296<div data-cmp-data-layer="{&#34;text-366aed396a&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-28T18:25:21Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>&lt;b>
3296CAP Guidelines provide direction on IHC assay validation to help ensure accuracy, reproducibility, and consistency of results&lt;sup>11&lt;/sup>&lt;/b>&lt;/h3>\n&#34;}}" id="text-366aed396a" class="cmp-text">
3297    <h3><b>CAP Guidelines provide direction on IHC assay validation to help ensure accuracy, reproducibility, and consistency of results<sup>11</sup></b></h3>
3298
3299</div>
3300
3301    
3302
3303</div>
3304
3305
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3313            </div>
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3317    
3318</div></div>
3319
3320		
3321		
3322	</div>
3323</div>
3324
3325    
3326    </div>
3327
3328
3329</section></div>
3330
3331    
3332    </div>
3333
3334</div>
3335<div class="container responsivegrid">
3336
3337    
3338    
3339    
3340    
3341    
3342    
3343
3344    <div id="container-d4f4d5bd14" class="cmp-container" style="background:#5D5F63;">
3345    
3346    <div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
3347<section style=";">
3348    
3349
3350    
3351    
3352    
3353    
3354    
3355    
3356
3357    <div id="container-69d5372e6b" class="cmp-container">
3358    
3359    <div class="text bottom-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
3360<div data-cmp-data-layer="{&#34;text-bc0407ae07&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:53:40Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>CLDN18.2 expression demonstrates intratumoral heterogeneity&lt;/h2>\n&#34;}}" id="text-bc0407ae07" class="cmp-text">
3361    <h2>CLDN18.2 expression demonstrates intratumoral heterogeneity</h2>
3362
3363</div>
3364
3365    
3366
3367</div>
3368<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3369<div data-cmp-data-layer="{&#34;text-64fecdf693&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-25T17:26:05Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>As with other biomarkers (such as HER2), CLDN18.2 expression in G/GEJ cancer exhibits intratumoral heterogeneity, which should be taken into account when sampling tumor tissue.&lt;sup>12,13&lt;/sup>&lt;/p>&#34;}}" id="text-64fecdf693" class="cmp-text">
3370    <p>As with other biomarkers (such as HER2), CLDN18.2 expression in G/GEJ cancer exhibits intratumoral heterogeneity, which should be taken into account when sampling tumor tissue.<sup>12,13</sup></p>
3371</div>
3372
3373    
3374
3375</div>
3376<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3377<div data-cmp-data-layer="{&#34;text-3997800a68&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-28T16:52:49Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>In a study showing high concordance between primary and metastatic tumor samples, &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>intratumoral heterogeneity in CLDN18.2 expression was observed in&lt;sup>12*&lt;/sup>:&lt;/span>&lt;/p>\n&#34;}}" id="text-3997800a68" class="cmp-text">
3378    <p>In a study showing high concordance between primary and metastatic tumor samples, <sp
3378an style="	color: rgb(85,236,141);
3379">intratumoral heterogeneity in CLDN18.2 expression was observed in<sup>12*</sup>:</span></p>
3380
3381</div>
3382
3383    
3384
3385</div>
3386<div class="image cmp-desktop">
3387 
3388
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3390    
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3392    
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3400<div class="image bottom-space-s cmp-mobile">
3401 
3402
3403<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off" data-asset-id="a108baa2-9f07-487b-9cb2-15892a319404" id="image-3c3ef5adec" data-cmp-data-layer="{&#34;image-3c3ef5adec&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-30T14:42:06Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;a108baa2-9f07-487b-9cb2-15892a319404&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:05Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-percentages-m.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
3404    
3405        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&ts=1790779326313&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=400&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=600&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=800&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=1000&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=1200&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=1400&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=1800&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-percentages-m?qlt=82&amp;wid=2000&amp;ts=1790779326313&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="1324" height="1324" alt/>
3406    
3407    
3408    
3409</div>
3410
3411    
3412
3413</div>
3414<div class="text bottom-space-l text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--white-500">
3415<div data-cmp-data-layer="{&#34;text-d6820133c8&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-24T16:46:20Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>*Data are from a single-institution study that assessed 523 archival cases of surgically treated gastric (n=408) and gastroesophageal (n=115) cancers. Intratumoral heterogeneity of CLDN18.2 was determined by assessing different samples from the same tumor for concomitant high and low CLDN18 expression.&lt;sup>12&lt;/sup>&lt;/p>\r\n&#34;}}" id="text-d6820133c8" class="cmp-text">
3416    <p>*Data are from a single-institution study that assessed 523 archival cases of surgically treated gastric (n&#61;408) and gastroesophageal (n&#61;115) cancers. Intratumoral heterogeneity of CLDN18.2 was determined by assessing different samples from the same tumor for concomitant high and low CLDN18 expression.<sup>12</sup></p>
3417
3418</div>
3419
3420    
3421
3422</div>
3423<div class="text bottom-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
3424<div data-cmp-data-layer="{&#34;text-50cacb83e7&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T18:04:36Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Navigating intratumoral heterogeneity&lt;sup>14&lt;/sup>&lt;/h2>&#34;}}" id="text-50cacb83e7" class="cmp-text">
3425    <h2>Navigating intratumoral heterogeneity<sup>14</sup></h2>
3426</div>
3427
3428    
3429
3430</div>
3431<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3432<div data-cmp-data-layer="{&#34;text-a8094661e3&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T18:10:49Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>A single-institution study in Italian patients with G/GEJ adenocarcinoma evaluated the sensitivity and specificity of CLDN18 testing according to the number of virtual biopsies scored on 93 surgically treated cases (77 GC and 16 GEJ), evaluated by two blinded pathologists.&lt;/p>\r\n&#34;}}" id="text-a8094661e3" class="cmp-text">
3433    <p>A single-institution study in Italian patients with G/GEJ adenocarcinoma evaluated the sensitivity and specificity of CLDN18 testing according to the number of virtual biopsies scored on 93 surgically treated cases (77 GC and 16 GEJ), evaluated by two blinded pathologists.</p>
3434
3435</div>
3436
3437    
3438
3439</div>
3440<div class="text bottom-space-3xs text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3441<div data-cmp-data-layer="{&#34;text-1137c4e116&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-09T17:02:45Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Using the CLDN18.2-positive cutoff of ≥75%:&lt;/p>\r\n&#34;}}" id="text-1137c4e116" class="cmp-text">
3442    <p>Using the CLDN18.2-positive cutoff of ≥75%:</p>
3443
3444</div>
3445
3446    
3447
3448</div>
3449<div class="text bottom-space-m text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3450<div data-cmp-data-layer="{&#34;text-4fb7df0fab&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-05T12:15:31Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\r\n&lt;li>Sensitivity increased steadily upon evaluating additional biopsies&lt;ul>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>From &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>92.9%&lt;/span> with 2 biopsies to &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>100%&lt;/span> with 9 biopsies&lt;/li>\r\n&lt;/ul>\r\n&lt;/li>\r\n&lt;li>After 6 biopsies, the increase was minimal&lt;ul>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>97.7% with 6 biopsies compared with 98.2% with 7 biopsies: &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>0.5% increase&lt;/span>&lt;/li>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>98.2% with 7 biopsies compared with 98.7% with 8 biopsies: &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>0.5% increase&lt;/span>&lt;/li>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>
345098.7% with 8 biopsies compared with 100% with 9 biopsies: &lt;span style=\&#34;color: rgb(85,236,141);\&#34;>1.3% increase&lt;/span>&lt;/li>\r\n&lt;/ul>\r\n&lt;/li>\r\n&lt;li>Similar results have been demonstrated for HER2 testing in G/GEJ adenocarcinoma&lt;/li>\r\n&lt;/ul>\r\n&#34;}}" id="text-4fb7df0fab" class="cmp-text">
3451    <ul><li>Sensitivity increased steadily upon evaluating additional biopsies<ul><li style="	list-style-type: disc;
3452">From <span style="	color: rgb(85,236,141);
3453">92.9%</span> with 2 biopsies to <span style="	color: rgb(85,236,141);
3454">100%</span> with 9 biopsies</li></ul>
3455</li><li>After 6 biopsies, the increase was minimal<ul><li style="	list-style-type: disc;
3456">97.7% with 6 biopsies compared with 98.2% with 7 biopsies: <span style="	color: rgb(85,236,141);
3457">0.5% increase</span></li><li style="	list-style-type: disc;
3458">98.2% with 7 biopsies compared with 98.7% with 8 biopsies: <span style="	color: rgb(85,236,141);
3459">0.5% increase</span></li><li style="	list-style-type: disc;
3460">98.7% with 8 biopsies compared with 100% with 9 biopsies: <span style="	color: rgb(85,236,141);
3461">1.3% increase</span></li></ul>
3462</li><li>Similar results have been demonstrated for HER2 testing in G/GEJ adenocarcinoma</li></ul>
3463
3464</div>
3465
3466    
3467
3468</div>
3469<div class="image cmp-mobile">
3470 
3471
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3487    
3488        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&ts=1790348523419&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=400&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=600&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=800&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=1000&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=1200&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=1400&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=1800&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphic-d?qlt=82&amp;wid=2000&amp;ts=1790348523419&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="5104" height="2552" alt="CLDN18.2-Positive Cutoff of ≥75%"/>
3489    
3490    
3491    
3492</div>
3493
3494    
3495
3496</div>
3497<div class="cardset">
3498	<div class="cmp-cardset single-card" data-cmp-data-layer="{&#34;cardset-963c6599a2&#34;:{&#34;dc:description&#34;:&#34;&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-04T17:19:09Z&#34;,&#34;xdm:linkURL&#34;:&#34;/content/claudin/hcp/north-america/us/en/prepare-and-test-samples&#34;,&#34;@type&#34;:&#34;global/components/globalcomponents/cardset/v1/cardset&#34;,&#34;dc:title&#34;:&#34;&#34;}}">
3499		<div class="card teaser card-secondary-dark cmp-teaser-content--dark">
3500    
3501
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3505
3506
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3508
3509<input type="hidden" name="resourcePath" id="resourcePath" value="/content/claudin/hcp/north-america/us/en/prepare-and-test-samples"/>
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3511<input type="hidden" name="subtype" id="subtype"/>
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3515<input type="hidden" name="jobcodeDetail" id="jobcodeDetail"/>
3516<!-- Card starts here -->
3517
3518<div class="cmp-teaser" id="card-6fd362700a" data-cmp-data-layer="{&#34;card-6fd362700a&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/card/v1/card&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T17:52:56Z&#34;}}" data-video-card="false" data-video-has-transcript="false" data-video-plain-transcript="false" data-cmp-typechecked="false" data-cmp-subtypechecked="false" data-cmp-channelchecked="false" data-cmp-seatavailabilitychecked="false" data-cmp-Datechecked="false" data-cmp-Jobcodechecked="false">
3519    <!-- image text  -->
3520
3521    
3522
3523
3524
3525    
3526        <!-- Load when carousel link is not enabled -->
3527        <div class="cmp-teaser__container no-image no-referencelist">
3528            
3529            <div class="cmp-teaser__content__wrapper">
3530                <!-- Content-->
3531                <div class="cmp-teaser__content">
3532                    <!--tags-->
3533                    
3534                    
3535                        
3536                    
3537                    <!-- Search Tags for Card -->
3538                    
3539
3540                    <!--kicker-->
3541
3542                    
3543
3544
3545                    <!--title-->
3546                    <div class="cmp-card__content__wrapper">
3547                        
3548                        
3549                        <!-- Time & Date from comp dialog-->
3550                        
3551                        <!-- Time & Date from page Properties-->
3552                        
3553                        <!-- Start & End Date from Response-->
3554                        
3555                        <!--description-->
3556                        
3557                    </div>
3558
3559                    <div class="text bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3560<div data-cmp-data-layer="{&#34;text-1d5aba3b78&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-07T19:21:13Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>&lt;b>Multiple biopsies (ideally, 6+, if tissue allows) should be obtained to more accurately evaluate CLDN18.2 expression.&lt;sup>14,15&lt;/sup>&lt;/b>&lt;/h3>\n&#34;}}" id="text-1d5aba3b78" class="cmp-text">
3561    <h3><b>Multiple biopsies (ideally, 6&#43;, if tissue allows) should be obtained to more accurately evaluate CLDN18.2 expression.<sup>14,15</sup></b></h3>
3562
3563</div>
3564
3565    
3566
3567</div>
3568
3569
3570                    
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3572                    <!-- Container -->
3573                    
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3577            </div>
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3580        
3581    
3582</div></div>
3583
3584		
3585		
3586	</div>
3587</div>
3588
3589    
3590    </div>
3591
3592
3593</section></div>
3594
3595    
3596    </div>
3597
3598</div>
3599<div class="container responsivegrid">
3600
3601    
3602    
3603    
3604    
3605    
3606    
3607
3608    <div id="container-46e1fdee8a" class="cmp-container" style="background:#35373C;">
3609    
3610    <div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
3611<section style=";">
3612    
3613
3614    
3615    
3616    
3617    
3618    
3619    
3620
3621    <div id="container-5df8232ed4" class="cmp-container">
3622    
3623    <div class="text bottom-space-m bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--white-500">
3624<div data-cmp-data-layer="{&#34;proficiency-evaluations&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-24T21:12:08Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Proficiency evaluations have identified variability in antibody and platform performance&lt;/h2>\r\n&#34;}}" id="proficiency-evaluations" class="cmp-text">
3625    <h2>Proficiency evaluations have identified variability in antibody and platform performance</h2>
3626
3627</div>
3628
3629    
3630
3631</div>
3632<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3633<div data-cmp-data-layer="{&#34;text-b1a54f6398&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:13:07Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Global concordance study&lt;sup>9&lt;/sup>&lt;/h3>&#34;}}" id="text-b1a54f6398" class="cmp-text">
3634    <h3>Global concordance study<sup>9</sup></h3>
3635</div>
3636
3637    
3638
3639</div>
3640<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3641<div data-cmp-data-layer="{&#34;text-9a2403f870&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-05-05T21:14:09Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>In the global concordance study, which assessed the reproducibility and comparability of three CLDN18 antibodies—VENTANA (43-14A), LSBio (LS-B16145), and Novus (NBP2-32002)—and IHC staining platforms across a cohort of 27 global laboratories, sensitivity, specificity, accuracy, and precision were analyzed.*&lt;sup>,†&lt;/sup>&lt;/p>&#34;}}" id="text-9a2403f870" class="cmp-text">
3642    <p>In the global concordance study, which assessed the reproducibility and comparability of three CLDN18 antibodies—VENTANA (43-14A), LSBio (LS-B16145), and Novus (NBP2-32002)—and IHC staining platforms across a cohort of 27 global laboratories, sensitivity, specificity, accuracy, and precision were analyzed.*<sup>,†</sup></p>
3643</div>
3644
3645    
3646
3647</div>
3648<div class="columncontainer responsivegrid">
3649    <div id="columncontainer-6d73717840" class="cmp-columncontainer  
3650         cmp-columncontainer--2col-2_1 cmp-columncontainer--spcol-1
3651         
3652         ">
3653        
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3656
3657
3658<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
3659    
3660    <div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500 aem-GridColumn aem-GridColumn--default--12">
3661<div data-cmp-data-layer="{&#34;text-b6d1f38dc6&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-19T22:05:45Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>Analytical performance of the VENTANA assay was &amp;gt;95% and reproducible across all of the 27 laboratories vs consensus reference results&lt;/li>\n&lt;li>Analytical performance was equivalent across the VENTANA (43-14A) IVD assay and the LSBio antibody when stained on the Dako or Leica platform; staining was also reproducible for the LSBio antibody&lt;/li>\n&lt;li>Performance was less consistent for the Novus antibody compared to the VENTANA assay&lt;/li>\n&lt;/ul>\n&#34;}}" id="text-b6d1f38dc6" class="cmp-text">
3662    <ul><li>Analytical performance of the VENTANA assay was &gt;95% and reproducible across all of the 27 laboratories vs consensus reference results</li><li>Analytical performance was equivalent across the VENTANA (43-14A) IVD assay and the LSBio antibody when stained on the Dako or Leica platform; staining was also reproducible for the LSBio antibody</li><li>Performance was less consistent for the Novus antibody compared to the VENTANA assay</li></ul>
3663
3664</div>
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3666    
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3681 
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3684    
3685        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&ts=1790720871259&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=400&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=600&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=800&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=1000&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=1200&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=1400&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=1800&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-d?qlt=82&amp;wid=2000&amp;ts=1790720871259&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="2508" height="1468" alt/>
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3697<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off" data-asset-id="ba26b74d-c4a2-4471-923f-350fc167f2a6" id="image-a5caa8e553" data-cmp-data-layer="{&#34;image-a5caa8e553&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-29T22:27:58Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;ba26b74d-c4a2-4471-923f-350fc167f2a6&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:05Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-95100-m.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
3698    
3699        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&ts=1790720878625&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=400&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=600&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=800&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=1000&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=1200&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=1400&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=1800&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-95100-m?qlt=82&amp;wid=2000&amp;ts=1790720878625&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="1324" height="744" alt/>
3700    
3701    
3702    
3703</div>
3704
3705    
3706
3707</div>
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3709    
3710</div>
3711</div>
3712        
3713    </div>
3714</div>
3715<div class="text bottom-space-s text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--white-500">
3716<div data-cmp-data-layer="{&#34;text-d4eec4825d&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-28T11:11:16Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>&lt;span class=\&#34;small-sup\&#34;>*&lt;/span>Antibodies in the study comprised the VENTANA CLDN18 (43-14A) IVD&amp;nbsp;Assay from Roche Tissue Diagnostics, the PathPlus™ CLDN18 Antibody from LSBio, and the Claudin-18 Antibody from Novus Biologicals. Platforms comprised BenchMark ULTRA, Dako Autostainer, and Leica Bond.&lt;/p>\r\n&#34;}}" id="text-d4eec4825d" class="cmp-text">
3717    <p><span class="small-sup">*</span>Antibodies in the study comprised the VENTANA CLDN18 (43-14A) IVD Assay from Roche Tissue Diagnostics, the PathPlus™ CLDN18 Antibody from LSBio, and the Claudin-18 Antibody from Novus Biologicals. Platforms comprised BenchMark ULTRA, Dako Autostainer, and Leica Bond.</p>
3718
3719</div>
3720
3721    
3722
3723</div>
3724<div class="text bottom-space-xl text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--white-500">
3725<div data-cmp-data-layer="{&#34;text-8445ad76bc&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-28T16:00:04Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>&lt;sup>†&lt;/sup>Consensus reference scores from all antibodies for each sample were determined by central pathology review. CLDN18.2 positivity was defined with a threshold of ≥75% of tumor cells expressing membranous CLDN18 with moderate-to-strong (≥2+) staining intensity. Accordingly, participating pathologists were required to submit a binary positive/negative call as well as an estimation of the percent of cells stained. Laboratory-submitted IHC scores were compared to the reference consensus score and considered discordant if the positive/negative binary result differed. Statistical analysis was performed for comparison, and an acceptance criteria of 85% (≥0.85) was applied.&lt;/p>&#34;}}" id="text-8445ad76bc" class="cmp-text">
3726    <p><sup>†</sup>Consensus reference scores from all antibodies for each sample were determined by central pathology review. CLDN18.2 positivity was defined with a threshold of ≥75% of tumor cells expressing membranous CLDN18 with moderate-to-strong (≥2&#43;) staining intensity. Accordingly, participating pathologists were required to submit a binary positive/negative call as well as an estimation of the percent of cells stained. Laboratory-submitted IHC scores were compared to the reference consensus score and considered discordant if the positive/negative binary result differed. Statistical analysis was performed for comparison, and an acceptance criteria of 85% (≥0.85) was applied.</p>
3727</div>
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3729    
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3731</div>
3732<div class="separator bottom-space-s top-space-s cmp-remove-margin-seperator cmp-separator--primary__mid"><div id="separator-4156359071" class="cmp-separator">
3733    <hr class="cmp-separator__horizontal-rule"/>
3734</div>
3735</div>
3736<div class="text bottom-space-m top-space-2xl bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3737<div data-cmp-data-layer="{&#34;text-56d26b24d5&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-13T15:51:51Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>NordiQC external quality assessment results from Run C17*&lt;/h3>\r\n&#34;}}" id="text-56d26b24d5" class="cmp-text">
3738    <h3>NordiQC external quality assessment results from Run C17*</h3>
3739
3740</div>
3741
3742    
3743
3744</div>
3745<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3746<div data-cmp-data-layer="{&#34;text-d3e7897b40&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-10T15:57:52Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>The objective of the NordiQC EQA was to evaluate the analytical accuracy of IHC assays for detecting CLDN18.2. 75 laboratories participated in this first assessment with ~87% (65/75) achieving a sufficient mark.&lt;sup>16&lt;/sup>&lt;/p>&#34;}}" id="text-d3e7897b40" class="cmp-text">
3747    <p>The objective of the NordiQC EQA was to evaluate the analytical accuracy of IHC assays for detecting CLDN18.2. 75 laboratories participated in this first assessment with ~87% (65/75) achieving a sufficient mark.<sup>16</sup></p>
3748</div>
3749
3750    
3751
3752</div>
3753<div class="text bottom-space-xs text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3754<div data-cmp-data-layer="{&#34;text-67e133c532&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-10T15:58:38Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\r\n&lt;li>“Sufficient” stains were defined as “optimal” +&amp;nbsp; “good”&lt;/li>\r\n&lt;/ul>\r\n&#34;}}" id="text-67e133c532" class="cmp-text">
3755    <ul><li>“Sufficient” stains were defined as “optimal” &#43;  “good”</li></ul>
3756
3757</div>
3758
3759    
3760
3761</div>
3762<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3763<div data-cmp-data-layer="{&#34;text-8bbf06a8d9&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-04-05T12:21:31Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\r\n&lt;li>100% of IHC stains submitted using the CE-IVD VENTANA CLDN18 (43-14A) Assay were marked as “sufficient,” of which ~89% (8/9) were “optimal”&lt;/li>\r\n&lt;li>For the assessment of 6 concentrated antibodies&lt;ul>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Only ~46% (6/13) of IHC stains submitted were marked as “sufficient”&lt;/li>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>The monoclonal antibody clone 43-14A was the most successful compared with other clones, with 80% (4/5) marked as “sufficient”&lt;/li>\r\n&lt;li style=\&#34;list-style-type: disc;\&#34;>Insufficient results were mainly caused by too weak or false negative staining reaction in gastric carcinomas expected to have ≥75% positivity&lt;/li>\r\n&lt;/ul>\r\n&lt;/li>\r\n&lt;/ul>\r\n&#34;}}" id="text-8bbf06a8d9" class="cmp-text">
3764    <ul><li>100% of IHC stains submitted using the CE-IVD VENTANA CLDN18 (43-14A) Assay were marked as “sufficient,” of which ~89% (8/9) were “optimal”</li><li>For the assessment of 6 concentrated antibodies<ul><li style="	list-style-type: disc;
3765">Only ~46% (6/13) of IHC stains submitted were marked as “sufficient”</li><li style="	list-style-type: disc;
3766">The monoclonal antibody clone 43-14A was the most successful compared with other clones, with 80% (4/5) marked as “sufficient”</li><li style="	list-style-type: disc;
3767">Insufficient results were mainly caused by too weak or false negative staining reaction in gastric carcinomas expected to have ≥75% positivity</li></ul>
3768</li></ul>
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3775<div class="image cmp-desktop">
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3779    
3780        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&ts=1790348525664&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=400&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=600&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=800&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=1000&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=1200&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=1400&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=1800&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-d?qlt=82&amp;wid=2000&amp;ts=1790348525664&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="5104" height="1880" alt="IHC Stains from VENTANA CLDN18.2(43-14A) Assay and Concentrated Antibodies"/>
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3792<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off" data-asset-id="8395d232-1fa8-4f7a-8f4b-2319b0a7a8ee" id="image-54e1b4a8ec" data-cmp-data-layer="{&#34;image-54e1b4a8ec&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:33:43Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;8395d232-1fa8-4f7a-8f4b-2319b0a7a8ee&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:01:59Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
3793    
3794        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&ts=1790348519806&$transperant$&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=400&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=600&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=800&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=1000&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=1200&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=1400&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=1800&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-graphics-ihc-m?qlt=82&amp;wid=2000&amp;ts=1790348519806&amp;$transperant$&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="1324" height="2316" alt="IHC Stains from VENTANA CLDN18.2(43-14A) Assay and Concentrated Antibodies"/>
3795    
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3798</div>
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3802</div>
3803<div class="text bottom-space-2xs text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--white-500">
3804<div data-cmp-data-layer="{&#34;text-ab8b0b4e1a&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-10T16:14:05Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>NordiQC is a professional scientific organization that conducts EQAs for immunohistochemistry proficiency.&lt;sup>17&lt;/sup>&lt;/p>&#34;}}" id="text-ab8b0b4e1a" class="cmp-text">
3805    <p>NordiQC is a professional scientific organization that conducts EQAs for immunohistochemistry proficiency.<sup>17</sup></p>
3806</div>
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3808    
3809
3810</div>
3811<div class="text text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--white-500">
3812<div data-cmp-data-layer="{&#34;text-084551dc0c&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-15T17:03:44Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>*NordiQC EQA sponsored by Astellas.&lt;/p>\r\n&#34;}}" id="text-084551dc0c" class="cmp-text">
3813    <p>*NordiQC EQA sponsored by Astellas.</p>
3814
3815</div>
3816
3817    
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3819</div>
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3821    
3822    </div>
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3824
3825</section></div>
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3828    </div>
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3830</div>
3831<div class="section-container container responsivegrid cmp-full-width-section bottom-padding-l top-padding-l">
3832<section style=";">
3833    
3834
3835    
3836    
3837    
3838    
3839    
3840    
3841
3842    <div id="container-1726e16d04" class="cmp-container">
3843    
3844    <div class="text bottom-space-l bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--page-title">
3845<div data-cmp-data-layer="{&#34;reflexive-testing&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-24T21:08:57Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>The G/GEJ adenocarcinoma landscape continues to evolve, with emerging considerations for testing approaches&lt;/h2>\r\n&#34;}}" id="reflexive-testing" class="cmp-text">
3846    <h2>The G/GEJ adenocarcinoma landscape continues to evolve, with emerging considerations for testing approaches</h2>
3847
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3852</div>
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3874<div class="cmp-teaser" id="card-f69952b730" data-cmp-data-layer="{&#34;card-f69952b730&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/card/v1/card&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:28:46Z&#34;}}" data-video-card="false" data-video-has-transcript="false" data-video-plain-transcript="false" data-cmp-typechecked="false" data-cmp-subtypechecked="false" data-cmp-channelchecked="false" data-cmp-seatavailabilitychecked="false" data-cmp-Datechecked="false" data-cmp-Jobcodechecked="false">
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3889                    
3890                    
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3903                        
3904                        
3905                        <!-- Time & Date from comp dialog-->
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3914
3915                    <div class="text bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--white-500">
3916<div data-cmp-data-layer="{&#34;text-dfd1256b46&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-19T21:49:37Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>&lt;b>Reflexive testing may improve patient care through timely availability of biomarker results and initiation of optimal systemic therapy&lt;sup>18&lt;/sup>&lt;/b>&lt;/h2>\n&#34;}}" id="text-dfd1256b46" class="cmp-text">
3917    <h2><b>Reflexive testing may improve patient care through timely availability of biomarker results and initiation of optimal systemic therapy<sup>18</sup></b></h2>
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3919</div>
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3923</div>
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3938</div></div>
3939
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3941		
3942	</div>
3943</div>
3944<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--neutral-500">
3945<div data-cmp-data-layer="{&#34;text-df87732ed2&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T22:21:50Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Rationale for Reflex Testing&lt;sup>18&lt;/sup>&lt;/h3>&#34;}}" id="text-df87732ed2" class="cmp-text">
3946    <h3>Rationale for Reflex Testing<sup>18</sup></h3>
3947</div>
3948
3949    
3950
3951</div>
3952<div class="text bottom-space-xl text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
3953<div data-cmp-data-layer="{&#34;text-7ea09877eb&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:30:26Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Expert consensus supports reflex biomarker testing in G/GEJ adenocarcinoma to ensure that clinically relevant biomarker results are available at the time of initial oncology consultation, helping to facilitate timely treatment decision‑making and improve overall patient care. &lt;/p>\n&#34;}}" id="text-7ea09877eb" class="cmp-text">
3954    <p>Expert consensus supports reflex biomarker testing in G/GEJ adenocarcinoma to ensure that clinically relevant biomarker results are available at the time of initial oncology consultation, helping to facilitate timely treatment decision‑making and improve overall patient care. </p>
3955
3956</div>
3957
3958    
3959
3960</div>
3961<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--neutral-500">
3962<div data-cmp-data-layer="{&#34;text-8e5ba431c7&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-19T22:08:29Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Initiation of Reflex Testing&lt;sup>18&lt;/sup>&lt;/h3>\n&#34;}}" id="text-8e5ba431c7" class="cmp-text">
3963    <h3>Initiation of Reflex Testing<sup>18</sup></h3>
3964
3965</div>
3966
3967    
3968
3969</div>
3970<div class="text bottom-space-l text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
3971<div data-cmp-data-layer="{&#34;text-c22226e1be&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:31:53Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Consensus recommendations favor a pathologist‑initiated reflex testing approach, activated once diagnostic histology is confirmed, rather than waiting for a separate clinician request. This model is intended to streamline the diagnostic pathway and reduce avoidable delays in care.&lt;/p>\n&#34;}}" id="text-c22226e1be" class="cmp-text">
3972    <p>Consensus recommendations favor a pathologist‑initiated reflex testing approach, activated once diagnostic histology is confirmed, rather than waiting for a separate clinician request. This model is intended to streamline the diagnostic pathway and reduce avoidable delays in care.</p>
3973
3974</div>
3975
3976    
3977
3978</div>
3979<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--neutral-500">
3980<div data-cmp-data-layer="{&#34;text-b0fcdb3cbc&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T22:22:05Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Biomarker Testing Approach&lt;sup>18&lt;/sup>&lt;/h3>&#34;}}" id="text-b0fcdb3cbc" class="cmp-text">
3981    <h3>Biomarker Testing Approach<sup>18</sup></h3>
3982</div>
3983
3984    
3985
3986</div>
3987<div class="text bottom-space-xl text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
3988<div data-cmp-data-layer="{&#34;text-44003ee900&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:32:58Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>Experts agreed that reflex testing should be considered based on tumor histology in patients with G/GEJ adenocarcinoma, with biomarker assessment coordinated as part of the initial diagnostic work‑up.&lt;/p>\n&#34;}}" id="text-44003ee900" class="cmp-text">
3989    <p>Experts agreed that reflex testing should be considered based on tumor histology in patients with G/GEJ adenocarcinoma, with biomarker assessment coordinated as part of the initial diagnostic work‑up.<
3989/p>
3990
3991</div>
3992
3993    
3994
3995</div>
3996<div class="text bottom-space-s bold-styling step-1 cmp-weight-styles bold cmp-element__colorcode--neutral-500">
3997<div data-cmp-data-layer="{&#34;text-ddfe085ecd&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T22:22:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Operational Principles for Reflex Testing&lt;sup>18&lt;/sup>&lt;/h3>&#34;}}" id="text-ddfe085ecd" class="cmp-text">
3998    <h3>Operational Principles for Reflex Testing<sup>18</sup></h3>
3999</div>
4000
4001    
4002
4003</div>
4004<div class="text bottom-space-s bold-styling step-0 cmp-weight-styles bold cmp-element__colorcode--neutral-500">
4005<div data-cmp-data-layer="{&#34;text-d9621bcbcd&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:34:41Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h3>Best‑practice implementation of reflex testing requires:&lt;/h3>\n&#34;}}" id="text-d9621bcbcd" class="cmp-text">
4006    <h3>Best‑practice implementation of reflex testing requires:</h3>
4007
4008</div>
4009
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4012</div>
4013<div class="text bottom-space-s text-styling step-0 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
4014<div data-cmp-data-layer="{&#34;text-e3edcceb56&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:35:12Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>Coordination across the full tissue pathway, from biopsy acquisition through testing and reporting&lt;/li>\n&lt;li>Use of standardized, quality‑assured laboratory processes to ensure accuracy and validity of results&lt;/li>\n&lt;li>Pathology reports that provide clear, sufficiently detailed biomarker results to support downstream clinical decision‑making &lt;/li>\n&lt;/ul>\n&#34;}}" id="text-e3edcceb56" class="cmp-text">
4015    <ul><li>Coordination across the full tissue pathway, from biopsy acquisition through testing and reporting</li><li>Use of standardized, quality‑assured laboratory processes to ensure accuracy and validity of results</li><li>Pathology reports that provide clear, sufficiently detailed biomarker results to support downstream clinical decision‑making </li></ul>
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4022<div class="container responsivegrid cmp-container-box-shadow cmp-container__padding cmp-corner-radius">
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4032    
4033    <div class="text bottom-space-xl bold-styling step-3 cmp-weight-styles bold cmp-element__colorcode--page-title">
4034<div data-cmp-data-layer="{&#34;text-79eba01916&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-04T20:36:35Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>&amp;quot;It’s critical that pathologists advocate for testing at diagnosis for all prevalent, actionable biomarkers.&amp;quot;&lt;/h2>\n&#34;}}" id="text-79eba01916" class="cmp-text">
4035    <h2>&#34;It’s critical that pathologists advocate for testing at diagnosis for all prevalent, actionable biomarkers.&#34;</h2>
4036
4037</div>
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4093        <img src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&ts=1790348523570&dpr=off" srcset="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=400&amp;ts=1790348523570&amp;dpr=off 400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=600&amp;ts=1790348523570&amp;dpr=off 600w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=800&amp;ts=1790348523570&amp;dpr=off 800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=1000&amp;ts=1790348523570&amp;dpr=off 1000w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=1200&amp;ts=1790348523570&amp;dpr=off 1200w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=1400&amp;ts=1790348523570&amp;dpr=off 1400w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=1800&amp;ts=1790348523570&amp;dpr=off 1800w,https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-prepare-and-test-samples-dr-matteo-fassan-d?qlt=82&amp;wid=2000&amp;ts=1790348523570&amp;dpr=off 2000w" loading="lazy" class="cmp-image__image" itemprop="contentUrl" width="408" height="408" alt="Profile photo of Dr. Matteo  Fassan "/>
4094    
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4102
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4105
4106<div class="illustration-container__content" id="illustration-container-e93faed395" data-cmp-data-layer="{&#34;illustration-container-e93faed395&#34;:{&#34;@type&#34;:&#34;/apps/global/components/globalcomponents/illustration-container/v1/illustration-container&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-04T01:34:04Z&#34;,&#34;dc:title&#34;:&#34;&lt;div class=\&#34;cmp-element__colorcode--secondary-card-title\&#34;>&lt;p> &lt;/p>\r\n&lt;h3>Matteo Fassan, MD, PhD&lt;/h3>\r\n&lt;/div>\r\n&#34;}}">
4107   
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4117&lt;h3>Matteo Fassan, MD, PhD&lt;/h3>
4118&lt;/div>
4119"><span><div class="cmp-element__colorcode--secondary-card-title"><p> </p>
4120<h3>Matteo Fassan, MD, PhD</h3>
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4165<section style=";">
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4176    
4177    <div class="text bottom-space-m bold-styling step-4 cmp-weight-styles bold cmp-element__colorcode--page-title">
4178<div data-cmp-data-layer="{&#34;text-330d0645b1&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-10T19:38:24Z&#34;,&#34;xdm:text&#34;:&#34;&lt;h2>Learn more about interpreting CLDN18.2&amp;nbsp;expression&lt;/h2>\r\n&#34;}}" id="text-330d0645b1" class="cmp-text">
4179    <h2>Learn more about interpreting CLDN18.2 expression</h2>
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4205					<span>Stain Interpretation</span>
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4236<section style=";">
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4248    <div class="text bottom-space-l text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--neutral-500">
4249<div data-cmp-data-layer="{&#34;text-6f90b99a5f&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-06-15T17:07:02Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>CAP, College of American Pathologists; CLDN18, claudin 18; CLDN18.1, claudin 18 isoform 1; CLDN18.2, claudin 18 isoform 2; EQA, external quality assessment; GC, gastric cancer; G/GEJ, gastric/gastroesophageal junction; HER2, human epidermal growth factor receptor-2; IHC, immunohistochemistry; IVD, in vitro diagnostic; RUO, research use only.&lt;/p>\r\n&#34;}}" id="text-6f90b99a5f" class="cmp-text">
4250    <p>CAP, College of American Pathologists; CLDN18, claudin 18; CLDN18.1, claudin 18 isoform 1; CLDN18.2, claudin 18 isoform 2; EQA, external quality assessment; GC, gastric cancer; G/GEJ, gastric/gastroesophageal junction; HER2, human epidermal growth factor receptor-2; IHC, immunohistochemistry; IVD, in vitro diagnostic; RUO, research use only.</p>
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4258<div data-cmp-data-layer="{&#34;text-937238250e&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-03-10T19:41:17Z&#34;,&#34;xdm:text&#34;:&#34;&lt;p>References:&lt;/p>\r\n&#34;}}" id="text-937238250e" class="cmp-text">
4259    <p>References:</p>
4260
4261</div>
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4266<div class="text text-styling step--1 cmp-weight-styles regular cmp-element__colorcode--neutral-500 cmp-reference--section cmp-reference--triple-number cmp-hyperlink--ondark cmp-custom-word-break">
4267<div data-cmp-data-layer="{&#34;text-bd9c72f038&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/text/v1/text&#34;,&#34;repo:modifyDate&#34;:&#34;2026-08-07T19:29:16Z&#34;,&#34;xdm:text&#34;:&#34;&lt;ul>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>1.&lt;/span>Compton CC, Robb JA, Anderson MW, et al. Preanalytics and precision pathology: pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine. &lt;i>Arch Pathol Lab Med.&lt;/i> 2019;143(11):1346-1363.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>2.&lt;/span>Ventana CLDN18 (43-14A) RxDx assay. Package insert. Tucson, AZ: Ventana Medical Systems, Inc; 2024.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>3.&lt;/span>Sahin U, Koslowski M, Dhaene K, et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. &lt;i>Clin Cancer Res.&lt;/i> 2008;14(23):7624-7634.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>4.&lt;/span>Hashimoto T, Iida N, Nakamura Y, et al. Landscape analysis of CLDN18 expression and isoform distribution in solid tumors: insights from MONSTAR-SCREEN-2 study. &lt;i>Cancer Sci.&lt;/i> 2025;116(8):2218-2231.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>5.&lt;/span>
4267Sun Y, Puspanathan P, Lim T, Lin D. Advances and challenges in gastric cancer testing: the role of biomarkers. &lt;i>Cancer Biol Med.&lt;/i> 2025;22(3):212-230.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>6.&lt;/span>Discovery Life Sciences. Recommended handling and storage for biological specimens. Published August 2023. Accessed June 30, 2026. https://dls.com/wp-content/uploads/2023/08/Recommended_Handling_and_Storage_for_Biological_Specimens_2020-2.pdf&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>7.&lt;/span>Abcam. Anti-claudin18 antibody [43-14A]. Accessed July 8, 2026. https://doc.abcam.com/datasheets/active/ab314690/en-us/claudin18-antibody-43-14a-ab314690.pdf&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>8.&lt;/span>LSBio. PathPlus CLDN18 Monoclonal Antibody Mouse IHC. Accessed July 15, 2026. https://www.lsbio.com/pathplus-antibodies/pathplus-cldn18-antibody-claudin-18-antibody-ihc-ls-b16145/789855#speci%EF%AC%81cations-section&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>9.&lt;/span>Jasani B, Taniere P, Schildhaus HU, et al. Global Ring Study to investigate the comparability of total assay performance of commercial claudin18 antibodies for evaluation in gastric cancer [published online November 8, 2023]. &lt;i>Lab Invest.&lt;/i> 2024. Accessed June 19, 2026. https://www.laboratoryinvestigation.org/action/showPdf?pii=S0023-6837%2823%2900227-1&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>10.&lt;/span>Fitzgibbons PL, Bradley LA, Fatheree LA, et al. Principles of analytic validation of immunohistochemical assays: guideline from the College of American Pathologists Pathology and Laboratory Quality Center. &lt;i>Arch Pathol Lab Med.&lt;/i> 2014;138(11):1432-1443.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>11.&lt;/span>Goldsmith JD, Troxell ML, Roy-Chowdhuri S, et al. Principles of analytic validation of immunohistochemical assays: guideline update. &lt;i>Arch Pathol Lab Med.&lt;/i> 2024;148(6):e111-e153.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>12.&lt;/span>Coati I, Lotz G, Fanelli GN, et al. Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. &lt;i>Br J Cancer.&lt;/i> 2019;121(3):257-263.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>13.&lt;/span>Grillo F, Fassan M, Sarocchi F, et al. HER2 heterogeneity in gastric/gastroesophageal cancers: from benchside to practice. &lt;i>World J Gastroenterol.&lt;/i> 2016;22(26):5879-5887.&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>14.&lt;/span>Pellino A, Brignola S, Riello E, et al. Association of CLDN18 protein expression with clinicopathological features and prognosis in advanced gastric and gastroesophageal junction adenocarcinomas [published online October 26, 2021]. &lt;i>J Pers Med.&lt;/i> 2021. Accessed April 3, 2026. https://www.mdpi.com/2075-4426/11/11/1095&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>15.&lt;/span>Pak S, Simon AG, Lyu SI, et al. The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric aden
4267ocarcinoma [published online August 7, 2025]. &lt;i>Sci Rep.&lt;/i> 2025. Accessed June 19, 2026. https://www.nature.com/articles/s41598-025-12337-4&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>16.&lt;/span>NordiQC. Assessment run C17 2025: Claudin 18.2 (CLDN18.2). Published April 7, 2025. Accessed June 19, 2026. https://www.nordiqc.org/downloads/assessments/206_123.pdf&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>17.&lt;/span>NordiQC. About NordiQC. Accessed August 4, 2025. https://www.nordiqc.org/about.php&lt;/li>\n&lt;li>&lt;span class=\&#34;cmp-weight-styles bold\&#34;>18.&lt;/span>West NP, Mansoor W, Taniere P, et al. Best-practice biomarker testing of oesophago-GC in the UK: expert consensus recommendations developed using a modified Delphi. &lt;i>Clin Oncol (R Coll Radiol).&lt;/i> 2024;36(11):701-709.&lt;/li>\n&lt;/ul>\n&#34;}}" id="text-bd9c72f038" class="cmp-text">
4268    <ul><li><span class="cmp-weight-styles bold">1.</span>Compton CC, Robb JA, Anderson MW, et al. Preanalytics and precision pathology: pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine. <i>Arch Pathol Lab Med.</i> 2019;143(11):1346-1363.</li><li><span class="cmp-weight-styles bold">2.</span>Ventana CLDN18 (43-14A) RxDx assay. Package insert. Tucson, AZ: Ventana Medical Systems, Inc; 2024.</li><li><span class="cmp-weight-styles bold">3.</span>Sahin U, Koslowski M, Dhaene K, et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. <i>Clin Cancer Res.</i> 2008;14(23):7624-7634.</li><li><span class="cmp-weight-styles bold">4.</span>Hashimoto T, Iida N, Nakamura Y, et al. Landscape analysis of CLDN18 expression and isoform distribution in solid tumors: insights from MONSTAR-SCREEN-2 study. <i>Cancer Sci.</i> 2025;116(8):2218-2231.</li><li><span class="cmp-weight-styles bold">5.</span>Sun Y, Puspanathan P, Lim T, Lin D. Advances and challenges in gastric cancer testing: the role of biomarkers. <i>Cancer Biol Med.</i> 2025;22(3):212-230.</li><li><span class="cmp-weight-styles bold">6.</span>Discovery Life Sciences. Recommended handling and storage for biological specimens. Published August 2023. Accessed June 30, 2026. https://dls.com/wp-content/uploads/2023/08/Recommended_Handling_and_Storage_for_Biological_Specimens_2020-2.pdf</li><li><span class="cmp-weight-styles bold">7.</span>Abcam. Anti-claudin18 antibody [43-14A]. Accessed July 8, 2026. https://doc.abcam.com/datasheets/active/ab314690/en-us/claudin18-antibody-43-14a-ab314690.pdf</li><li><span class="cmp-weight-styles bold">8.</span>LSBio. PathPlus CLDN18 Monoclonal Antibody Mouse IHC. Accessed July 15, 2026. https://www.lsbio.com/pathplus-antibodies/pathplus-cldn18-antibody-claudin-18-antibody-ihc-ls-b16145/789855#speci%EF%AC%81cations-section</li><li><span class="cmp-weight-styles bold">
42689.</span>Jasani B, Taniere P, Schildhaus HU, et al. Global Ring Study to investigate the comparability of total assay performance of commercial claudin18 antibodies for evaluation in gastric cancer [published online November 8, 2023]. <i>Lab Invest.</i> 2024. Accessed June 19, 2026. https://www.laboratoryinvestigation.org/action/showPdf?pii&#61;S0023-6837%2823%2900227-1</li><li><span class="cmp-weight-styles bold">10.</span>Fitzgibbons PL, Bradley LA, Fatheree LA, et al. Principles of analytic validation of immunohistochemical assays: guideline from the College of American Pathologists Pathology and Laboratory Quality Center. <i>Arch Pathol Lab Med.</i> 2014;138(11):1432-1443.</li><li><span class="cmp-weight-styles bold">11.</span>Goldsmith JD, Troxell ML, Roy-Chowdhuri S, et al. Principles of analytic validation of immunohistochemical assays: guideline update. <i>Arch Pathol Lab Med.</i> 2024;148(6):e111-e153.</li><li><span class="cmp-weight-styles bold">12.</span>Coati I, Lotz G, Fanelli GN, et al. Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases. <i>Br J Cancer.</i> 2019;121(3):257-263.</li><li><span class="cmp-weight-styles bold">13.</span>Grillo F, Fassan M, Sarocchi F, et al. HER2 heterogeneity in gastric/gastroesophageal cancers: from benchside to practice. <i>World J Gastroenterol.</i> 2016;22(26):5879-5887.</li><li><span class="cmp-weight-styles bold">14.</span>Pellino A, Brignola S, Riello E, et al. Association of CLDN18 protein expression with clinicopathological features and prognosis in advanced gastric and gastroesophageal junction adenocarcinomas [published online October 26, 2021]. <i>J Pers Med.</i> 2021. Accessed April 3, 2026. https://www.mdpi.com/2075-4426/11/11/1095</li><li><span class="cmp-weight-styles bold">15.</span>Pak S, Simon AG, Lyu SI, et al. The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric aden
4268ocarcinoma [published online August 7, 2025]. <i>Sci Rep.</i> 2025. Accessed June 19, 2026. https://www.nature.com/articles/s41598-025-12337-4</li><li><span class="cmp-weight-styles bold">16.</span>NordiQC. Assessment run C17 2025: Claudin 18.2 (CLDN18.2). Published April 7, 2025. Accessed June 19, 2026. https://www.nordiqc.org/downloads/assessments/206_123.pdf</li><li><span class="cmp-weight-styles bold">17.</span>NordiQC. About NordiQC. Accessed August 4, 2025. https://www.nordiqc.org/about.php</li><li><span class="cmp-weight-styles bold">18.</span>West NP, Mansoor W, Taniere P, et al. Best-practice biomarker testing of oesophago-GC in the UK: expert consensus recommendations developed using a modified Delphi. <i>Clin Oncol (R Coll Radiol).</i> 2024;36(11):701-709.</li></ul>
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4370<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
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4386<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-footer-logo-v2-d?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348523746&amp;$transperant$&amp;dpr=off" data-asset-id="1d4e30db-e4b6-4a57-af96-9b372cd8318a" id="image-c783caafda" data-cmp-data-layer="{&#34;image-c783caafda&#34;:{&#34;@type&#34;:&#34;core/wcm/components/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-08T16:23:41Z&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;1d4e30db-e4b6-4a57-af96-9b372cd8318a&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:03Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-footer-logo-v2-d.png&#34;}}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
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4389    
4390    
4391    
4392</div>
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4396</div>
4397
4398    
4399    </div>
4400
4401</div>
4402
4403    
4404</div>
4405</div>
4406        
4407            
4408            <div class="cmp-columncontainer-item">
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4410
4411<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
4412    
4413    
4414    
4415</div>
4416</div>
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4429
4430<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
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4432    <div class="global-nav cmp-footer-nav footer-font-color aem-GridColumn aem-GridColumn--default--12">
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4434
4435
4436
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4438
4439    
4440<link rel="stylesheet" href="/etc.clientlibs/global/components/globalcomponents/navigation/global-nav/v1/global-nav/clientlib.min.00c5b0695886693e98b8a8181bf8ae9f.css" type="text/css">
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4442
4443
4444
4445
4446<div class="clshidden">
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4451    <div class="primary-nav ">
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4456 
4457
4458<div data-cmp-is="image" data-cmp-widths="400,600,800,1000,1200,1400,1800,2000" data-cmp-dmimage data-cmp-src="https://s7d1.scene7.com/is/image/astellasuat/cldn182-hcp-footer-logo-v2?qlt=82&amp;wid=%7B.width%7D&amp;ts=1790348520250&amp;$transperant$&amp;wid=248&amp;dpr=off" data-asset-id="d0dd0f43-ccbf-4519-a5ad-fb1e8e0a9a2b" id="image-e32d412de4" data-cmp-data-layer="{&#34;image-e32d412de4&#34;:{&#34;@type&#34;:&#34;global/components/globalcomponents/image/v3/image&#34;,&#34;repo:modifyDate&#34;:&#34;2026-07-08T15:25:21Z&#34;,&#34;xdm:linkURL&#34;:&#34;https://www.astellas.com/en/&#34;,&#34;image&#34;:{&#34;repo:id&#34;:&#34;d0dd0f43-ccbf-4519-a5ad-fb1e8e0a9a2b&#34;,&#34;repo:modifyDate&#34;:&#34;2026-09-25T15:02:00Z&#34;,&#34;@type&#34;:&#34;image/png&#34;,&#34;repo:path&#34;:&#34;/content/dam/claudin/hcp/north-america/us/en/images/cldn182-hcp-footer-logo-v2.png&#34;},&#34;dc:title&#34;:&#34;cldn182-hcp-footer-logo-v2&#34;,&#34;xdm:linkType&#34;:&#34;external&#34;,&#34;xdm:linkTarget&#34;:&#34;_blank&#34;}}" data-cmp-hook-image="imageV3" class="cmp-image " itemscope itemtype="http://schema.org/ImageObject">
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4461    </a>
4462    
4463    
4464</div>
4465
4466    
4467
4468
4469
4470                </div>
4471            </div>
4472
4473            
4474            
4475        </div>
4476
4477
4478        
4479        <div class="primary-nav__middlenav">
4480            <div class="cmp-nav navigation">
4481
4482                
4483
4484
4485
4486                <!-- Added for right nav links in hamburger start code-->
4487
4488                
4489
4490                
4491
4492                
4493
4494
4495                <!-- Added for right nav links in hamburger End code-->
4496
4497                
4498                
4499            </div>
4500            <div class="primary-nav__middlenav--gradient"></div>
4501        </div>
4502        <div class="nav primary-nav__rightnav search">
4503            
4504            <div class="hamburger-container">
4505                <div class="hamburger-container__open">
4506                        <span translate="no" aria-hidden="true" class="material-symbols-rounded notranslate">
4507                            menu
4508                        </span>
4509                </div>
4510                <div class="hamburger-container__close">
4511                        <span translate="no" aria-hidden="true" class="material-symbols-rounded notranslate">
4512                            close
4513                        </span>
4514                </div>
4515            </div>
4516        </div>
4517        
4518        <!-- Edit Profile and child menus ofr right nav links changes-->
4519        <div class="nav above-brand-nav__rightnav">
4520            
4521            <div class="cmp-nav">
4522                
4523            </div>
4524            <!-- Edit Profile and child menus ofr right nav links changes-->
4525        </div>
4526    </div>
4527</div>
4528
4529    
4530
4531
4532</div>
4533
4534    
4535</div>
4536</div>
4537        
4538            
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4540
4541
4542<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
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4550            
4551            <div class="cmp-columncontainer-item">
4552
4553
4554<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
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4556    
4557    
4558</div>
4559</div>
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4562            <div class="cmp-columncontainer-item">
4563
4564
4565<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
4566    
4567    
4568    
4569</div>
4570</div>
4571        
4572            
4573            <div class="cmp-columncontainer-item">
4574
4575
4576<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
4577    
4578    
4579    
4580</div>
4581</div>
4582        
4583            
4584            <div class="cmp-columncontainer-item">
4585
4586
4587<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
4588    
4589    <div class="global-link cmp-global-link-link bottom-space-2xs step--1 cmp--link-color-white aem-GridColumn aem-GridColumn--default--12">
4590	
4591    
4592
4593    
4594	<ul>
4595		<li>
4596			
4597				
4598				
4599					<!--  Not dowload -->
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4607					
4608					<span>Site Map</span>
4609					
4610					
4611					</a>
4612				
4613				
4614			
4615			
4616			
4617			
4618
4619			
4620			
4621            
4622			
4623			
4624		</li>
4625	</ul>
4626</div>
4627<div class="global-link cmp-global-link-link bottom-space-2xs step--1 cmp--link-color-white aem-GridColumn aem-GridColumn--default--12">
4628	
4629    
4630
4631    
4632	<ul>
4633		<li>
4634			
4635			
4636			
4637			
4638
4639			
4640				
4641				
4642					<a href="javascript:void(0);" class="actionModalOpen" data-modal-id="redirect-1" data-modal-link="https://www.astellas.com/en/privacy-policy" data-cmp-data-layer="{&#34;global-link-b0e0e53968-headerlink-item0null&#34;:{
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4648}}" target="_self" data-cmp-clickable>
4649					
4650					<span>Privacy Policy</span>
4651					
4652					
4653					</a>
4654				
4655			
4656			
4657            
4658			
4659			
4660		</li>
4661	</ul>
4662</div>
4663<div class="global-link cmp-global-link-link bottom-space-2xs step--1 cmp--link-color-white aem-GridColumn aem-GridColumn--default--12">
4664	
4665    
4666
4667    
4668	<ul>
4669		<li>
4670			
4671				
4672				
4673					<!--  Not dowload -->
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4679  &#34;dc:title&#34; : &#34;Terms of Use&#34;
4680}}" target="_self" data-cmp-clickable>
4681					
4682					<span>Terms of Use</span>
4683					
4684					
4685					</a>
4686				
4687				
4688			
4689			
4690			
4691			
4692
4693			
4694			
4695            
4696			
4697			
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4699	</ul>
4700</div>
4701<div class="global-link cmp-global-link-link step--1 cmp--link-color-white aem-GridColumn aem-GridColumn--default--12">
4702	
4703    
4704
4705    
4706	<ul>
4707		<li>
4708			
4709			
4710			
4711			
4712
4713			
4714				
4715				
4716					<a href="javascript:void(0);" class="actionModalOpen" data-modal-id="redirect-2" data-modal-link="https://www.astellas.com/en/contact-us" data-cmp-data-layer="{&#34;global-link-03587df32b-headerlink-item0null&#34;:{
4717  &#34;xdm:linkTarget&#34; : &#34;_blank&#34;,
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4719  &#34;xdm:linkURL&#34; : &#34;https://www.astellas.com/en/contact-us&#34;,
4720  &#34;@type&#34; : &#34;global/components/globalcomponents/navigation/global-link/v1/global-link/link&#34;,
4721  &#34;dc:title&#34; : &#34;Contact Us&#34;
4722}}" target="_blank" data-cmp-clickable>
4723					
4724					<span>Contact Us</span>
4725					
4726					
4727					</a>
4728				
4729			
4730			
4731            
4732			
4733			
4734		</li>
4735	</ul>
4736</div>
4737
4738    
4739</div>
4740</div>
4741        
4742    </div>
4743</div>
4744
4745    
4746</div>
4747</div>
4748        
4749    </div>
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4757    
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4760    
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4762    
4763
4764    <div id="container-8af9ee9f8d" class="cmp-container">
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4768    <p><br />
4769Access to and use of this Site is subject to the Terms of Use available <a href="/content/claudin/hcp/north-america/us/en/terms-of-use" style="	color: rgb(255,255,255) !important;
4770	text-decoration: none !important;
4771">here</a>. This Site was developed and is maintained by Astellas. All trademarks are the property of their respective owners.</p>
4772<p>All case reviews and consensus scoring has been independently conducted by the members of the KEE Committee.<br />
4773©2026 Astellas Pharma, Inc. All rights reserved.</p>
4774<p>MAT-US-NON-2026-00363 | August 2026</p>
4775
4776</div>
4777
4778    
4779
4780</div>
4781
4782    
4783    </div>
4784
4785</div>
4786
4787    
4788    </div>
4789
4790
4791</section></div>
4792
4793    
4794</div>
4795
4796    </div>
4797
4798    
4799</div>
4800</div>
4801
4802
4803    
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4805
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4810
4811              
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4820
4821
4822
4823
4824
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4826
4827    
4828
4829    
4830
4831
4832
4833    
4834    
4835
4836          
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4840  

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