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163 <div class="container"> 164 <div class="collapse navbar-collapse d-sm-none" id="navbarText"> 165 <ul class="navbar-nav ms-auto mb-2 mb-lg-0"> 166 167 <li class="nav-item dropdown"> 168 <a href="/home-2/" title="What is Early Check?" class="nav-link active dropdown-toggle" role="button" data-bs-toggle="dropdown" aria-expanded="false""> 169 What is Early Check? 170 </a> 171 172 <ul class="dropdown-menu bg-primary"> 173 <li> 174 175 176 <a href="/what-is-early-check/conditions-tested/" title="What Conditions are Tested by Early Check?" class="dropdown-item nav-item__child active">What Conditions are Tested by Early Check?</a> 177 178 <a href="/what-is-early-check/conditions-previously-screened/" title="Condition Screening History" class="dropdown-item nav-item__child">Condition Screening History</a> 179 180 <a href="/what-is-early-check/frequently-asked-questions/" title="Frequently Asked Questions" class="dropdown-item nav-item__child">Frequently Asked Questions</a> 181 182 <a href="/what-is-early-check/who-we-are/" title="Who We Are" class="dropdown-item nav-item__child">Who We Are</a> 183 184 <a href="/what-is-early-check/early-check-supporters/" title="Early Check Supporters" class="dropdown-item nav-item__child">Early Check Supporters</a> 185 186 </li> 187 </ul> 188 189 </li> 190 191 <li class="nav-item"> 192 <a href="/how-early-check-works/" title="How Early Check Works" class="nav-link"> 193 How Early Check Works 194 </a> 195 196 </li> 197 198 <li class="nav-item dropdown"> 199 <a href="/for-health-care-providers/what-healthcare-providers-need-to-know/" title="What Health Care Providers Need to Know" class="nav-link dropdown-toggle" role="button" data-bs-toggle="dropdown" aria-expanded="false""> 200 What Health Care Providers Need to Know 201 </a> 202 203 <ul class="dropdown-menu bg-primary"> 204 <li> 205 206 207 <a href="/for-health-care-providers/what-healthcare-providers-need-to-know/" title="What Healthcare Providers Need to Know" class="dropdown-item nav-item__child">What Healthcare Providers Need to Know</a> 208 209 <a href="/for-health-care-providers/type-1-diabetes-risk-screening/" title="Type 1 Diabetes Risk Screening" class="dropdown-item nav-item__child">Type 1 Diabetes Risk Screening</a> 210 211 </li> 212 </ul> 213 214 </li> 215 216 <li class="nav-item dropdown"> 217 <a href="/data-and-impact/early-check-facts-and-figures/" title="Data and Impact" class="nav-link dropdown-toggle" role="button" data-bs-toggle="dropdown" aria-expanded="false""> 218 Data and Impact 219 </a> 220 221 <ul class="dropdown-menu bg-primary"> 222 <li> 223 224 225 <a href="/data-and-impact/early-check-facts-and-figures/" title="Early Check Facts and Figures" class="dropdown-item nav-item__child">Early Check Facts and Figures</a> 226 227 <a href="/data-and-impact/early-check-in-the-news/" title="Early Check In the News" class="dropdown-item nav-item__child">Early Check In the News</a> 228 229 <a href="/data-and-impact/publications/" title="Publications" class="dropdown-item nav-item__child">Publications</a> 230 231 <a href="/data-and-impact/parent-stories/" title="Parent Stories" class="dropdown-item nav-item__child">Parent Stories</a> 232 233 </li> 234 </ul> 235 236 </li> 237 238 </ul> 239 </div> 240 </div> 241</nav 242 243 244<span> 245 <div class="herobar container-fluid px-0" style="background-image: url(/assets/Uploads/heroimages/What-is-Early-Check__ScaleMaxHeightWzM3MF0.jpg); background-position-x: 100%; background-color: #C8E0EA;"> 246 <div class="container h-100"> 247 <div class="row h-100 align-items-end mb-4"> 248 249 <h1 class="herobar__header col-12 col-lg-6 d-none d-md-block">What Conditions are Tested by Early Check?</h1> 250 251 </div> 252 </div> 253 </div> 254</span> 255 256 257 <span> 258 <main class="container-fluid flex-grow-1 py-3"> 259 <div class="container"> 260 <div class="row"> 261 <div class="col-12"> 262 263 <div class="breadcrumbs mb-5"> 264 265 266 <a href="/home-2/"> 267 What is Early Check? 268 269 270 271 272 </a> / 273 274 275 276 What Conditions are Tested by Early Check? 277 278 279 </div> 280 281 282 </div> 283 <div id="cms" class="col-12 col-lg-8 main__center"> 284 285 <h1 class="herobar__header d-md-none d-lg-none">What Conditions are Tested by Early Check?</h1> 286 287 288 <div class="page__header-wrapper mb-4"> 289 290 <h2 class="page__head">From September 2023-October 2025, Early Check offered screening for hun
290dreds of serious health conditions and the risk for type 1 diabetes.</h2> 291 292 293 </div> 294 295 <p><span class="NormalTextRun SCXW56308778 BCX0">All babies born in North Carolina are already screened </span><span class="NormalTextRun SCXW56308778 BCX0">shortly after birth </span><span class="NormalTextRun SCXW56308778 BCX0">for over 60</span> <span class="NormalTextRun SCXW56308778 BCX0">health conditions </span><span class="NormalTextRun SCXW56308778 BCX0">as part of standard </span><span class="NormalTextRun SCXW56308778 BCX0">newborn screening</span><span class="NormalTextRun SCXW56308778 BCX0">. </span></p><p><span class="NormalTextRun SCXW56308778 BCX0">Early Check </span><span class="NormalTextRun SCXW56308778 BCX0">provided</span><span class="NormalTextRun SCXW56308778 BCX0"> extra, optional testing for babies whose parents sign up for the </span><span class="NormalTextRun SCXW56308778 BCX0">study</span><span class="NormalTextRun SCXW56308778 BCX0">.⯠</span><span class="NormalTextRun SCXW56308778 BCX0">Conditions tested by</span><span class="NormalTextRun SCXW56308778 BCX0"> Early Check changed over time. Since Early Check began, conditions were added and removed as we learned more about them. </span></p><p><span class="NormalTextRun SCXW56308778 BCX0">Our team of experts reviewed and selected these conditions using a common set of guidelines. Below you can find </span><span class="NormalTextRun SCXW56308778 BCX0">brief </span><span class="NormalTextRun SCXW56308778 BCX0">descriptions of the kinds of </span><span class="NormalTextRun SCXW56308778 BCX0">conditions screened by Early Check</span>. </p><div class="question-wrapper"> 296<h3 class="main__head">Is Early Check screening perfect?</h3> 297<ul> 298<li data-leveltext="ï·" data-font="Symbol" data-listid="40" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Early Check screening does not find all health conditions in all babies.</span></li> 299<li data-leveltext="ï·" data-font="Symbol" data-listid="40" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">If Early Check found a potential health condition in a baby, follow-up testing was done to learn more.</span></li> 300<li data-leveltext="ï·" data-font="Symbol" data-listid="39" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">All babies are different. For babies with the health conditions screened through Early Check, the study team and doctors will not know exactly when their symptoms will start and how severe the symptoms will be.</span></li> 301</ul> 302<h3 class="main__head">Conditions Screened by Early Check<span class="TrackChangeTextInsertion TrackedChange SCXW55613783 BCX8"><span class="TextRun SCXW55613783 BCX8" data-contrast="auto"><span class="NormalTextRun SCXW55613783 BCX8"><span> </span>September 2023-</span></span></span><span class="TrackChangeTextInsertion TrackedChange SCXW55613783 BCX8"><span class="TextRun SCXW55613783 BCX8" data-contrast="auto"><span class="NormalTextRun SCXW55613783 BCX8">October</span></span></span><span class="TrackChangeTextInsertion TrackedChange SCXW55613783 BCX8"><span class="TextRun SCXW55613783 BCX8" data-contrast="auto"><span class="NormalTextRun SCXW55613783 BCX8"><span> </span>2025.</span></span></span></h3> 303<p><div class="accordion mb-3 accordionOne" id="accordion-6"><div class="accordion-item"> 304 <h6 class="accordion-header" id="flush-heading-Group1-TreatableConditions"> 305 <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-14" aria-expanded="false" aria-controls="flush-14">Group 1 - Treatable Conditions</button> 306 </h6> 307 <div id="flush-14" class="accordion-collapse collapse" aria-labelledby="flush-heading-Group1-TreatableConditions" data-bs-parent="#accordion-6"> 308 <div class="accordion-body"> 309 <p></p><ul> 310<li data-leveltext="ï·" data-font="Symbol" data-listid="26" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span>Early Check </span><span>used DNA sequencing to screen for over</span> <span>100</span><span> rare genetic conditions that can be managed with </span><span>early treatment</span><span>.</span></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> 311<li data-leveltext="ï·" data-font="Symbol" data-listid="26" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span>These conditions usually cause serious symptoms or </span><span>d</span><span>eath</span> <span>if not treated early.</span></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> 312<li data-leveltext="ï·" data-font="Symbol" data-listid="26" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span>All babies signed up for Early Check were tested for </span><span>these treatable conditions</span><span>.</span></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> 313</ul><p><em><strong><span class="TextRun SCXW170220222 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW170220222 BCX0">What are some examples of </span><span class="NormalTextRun SCXW170220222 BCX0">health </span><span class="NormalTextRun SCXW170220222 BCX0">conditions in this group?</span></span></strong></em></p><ul> 314<li><span class="TextRun SCXW170220222 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW170220222 BCX0"><span class="TextRun SCXW63746876 BCX0" data-contrast="auto"><span class="NormalTextRun CommentStart SCXW63746876 BCX0">Examples include some types of childhood cancers, like retinoblastoma; genetic conditions that affect heart rhythm, like </span><span class="NormalTextRun SpellingErrorV2Themed SCXW63746876 BCX0">Jervell</span><span class="NormalTextRun SCXW63746876 BCX0"> and Lange-Nielsen syndrome; neonatal diabetes; genetic forms of bleeding disorders, like hemophilia; and many more.</span></span></span></span></li> 315</ul><p><em><strong><span class="TextRun SCXW170220222 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW170220222 BCX0"><span class="TextRun SCXW63746876 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW63746876 BCX0"><span class="TextRun SCXW171957262 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW171957262 BCX0">Why is early diagnosis important?</span></span></span></span></span></span></strong></em></p><ul> 316<li><span class="TextRun SCXW170220222 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW170220222 BCX0"><span class="TextRun SCXW63746876 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW63746876 BCX0"><span class="TextRun SCXW171957262 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW171957262 BCX0"><span class="TextRun SCXW12707291 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW12707291 BCX0">Early diagnosis and treatment </span><span class="NormalTextRun SCXW12707291 BCX0">can </span><span class="NormalTextRun SCXW12707291 BCX0">
316prevent or improve most serious symptoms </span><span class="NormalTextRun SCXW12707291 BCX0">and </span><span class="NormalTextRun SCXW12707291 BCX0">can be </span><span class="NormalTextRun SCXW12707291 BCX0">life-saving</span><span class="NormalTextRun SCXW12707291 BCX0"> for some conditions</span><span class="NormalTextRun SCXW12707291 BCX0">.</span></span></span></span></span></span></span></span></li> 317</ul> 318 </div> 319 </div> 320 </div></div></p> 321<p><div class="accordion mb-3 accordionOne" id="accordion-7"><div class="accordion-item"> 322 <h6 class="accordion-header" id="flush-heading-Group2Optional-ConditionswithPotentialTreatments"> 323 <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-15" aria-expanded="false" aria-controls="flush-15">Group 2 Optional - Conditions with Potential Treatments</button> 324 </h6> 325 <div id="flush-15" class="accordion-collapse collapse" aria-labelledby="flush-heading-Group2Optional-ConditionswithPotentialTreatments" data-bs-parent="#accordion-7"> 326 <div class="accordion-body"> 327 <p></p><ul> 328<li data-leveltext="ï·" data-font="Symbol" data-listid="27" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Early Check used DNA sequencing to look for a smaller group of rare genetic conditions that currently have less effective treatments.</span></li> 329<li data-leveltext="ï·" data-font="Symbol" data-listid="27" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">These conditions usually cause babies or children to have serious symptoms that </span><strong>may not </strong><span data-contrast="auto">be prevented with existing treatments. For some, research studies to improve care for children with these conditions are happening now.</span></li> 330<li data-leveltext="ï·" data-font="Symbol" data-listid="27" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":1080,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Parents were able to choose if they wanted to sign their baby up to be screened for the conditions in Group 2.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> 331</ul><p><em><strong>What are some examples of health conditions in this group? </strong></em></p><ul> 332<li><span data-contrast="auto">Examples include some types of intellectual and developmental disability; some muscle disorders, like Duchenne muscular dystrophy; and many more.</span><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":160,"335559740":259}"> </span></li> 333</ul><p><em><strong>Why is early diagnosis helpful? </strong></em></p><ul> 334<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Early diagnosis, medicines, and special care may help to give children with these conditions the best possible start and may allow children to take part in studies that could lead to better treatments.</span><span data-ccp-props="{"201341983":0,"335559685":1080,"335559739":160,"335559740":259}"> </span></li> 335</ul> 336 </div> 337 </div> 338 </div></div></p> 339<p><div class="accordion mb-3 accordionOne" id="accordion-8"><div class="accordion-item"> 340 <h6 class="accordion-header" id="flush-heading-Group3OptionalâRiskforType1Diabetes(T1D)"> 341 <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-16" aria-expanded="false" aria-controls="flush-16">Group 3 Optional â Risk for Type 1 Diabetes (T1D)</button> 342 </h6> 343 <div id="flush-16" class="accordion-collapse collapse" aria-labelledby="flush-heading-Group3OptionalâRiskforType1Diabetes(T1D)" data-bs-parent="#accordion-8"> 344 <div class="accordion-body"> 345 <p></p><ul> 346<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Early Check provided parents the opportunity to learn their babyâs genetic </span><span data-contrast="auto">risk</span><span data-contrast="auto"> for type 1 diabetes. Type 1 diabetes is a fairly common and </span><span style="text-decoration: underline;">treatable</span><span data-contrast="auto"> health condition and is the most common form of diabetes in children. <span style="color: #005663;"><em>(</em></span></span><span style="color: #005663;"><em>Note: Type 1 Diabetes is <span style="text-decoration: underline;">not</span> the same as type 2 diabetes, which is more common in adults.)</em></span></li> 347<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Type 1 diabetes causes serious symptoms or death if not treated.</span></li> 348<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Babies are not born with type 1 diabetes, but it can show up later in childhood.</span></li> 349<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Early Check used information from DNA sequencing to calculate the baby's risk of getting T1D during their lifetime. This screening test does not give a âyesâ or ânoâ answer.</sp
349an></li> 350<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Parents were able to choose if they wanted to sign their baby up to be screened for the </span><span data-contrast="auto">risk</span><span data-contrast="auto"> of type 1 diabetes.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"> </span></li> 351<li data-leveltext="ï·" data-font="Symbol" data-listid="25" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"ï·","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">Learn more about screening for T1D <a rel="noopener" href="https://vimeo.com/900861702?share=copy" target="_blank">here</a>.</span></li> 352</ul><p><em><strong>Why is this information important?</strong></em></p><ul> 353<li><span data-contrast="auto">For babies with a higher risk for type 1 diabetes, parents and doctors can watch for signs of the condition as they grow. This could lead to earlier diagnosis, treatment, and better health for a child with type 1 diabetes.</span></li> 354</ul> 355 </div> 356 </div> 357 </div></div></p> 358<div thumbnail="https://i.vimeocdn.com/video/1779445183-3a6c1e28622e22663bdd48fd4178cd76c383dfbe34c43c703ae9016efacfbddf-d_295x166?region=us" class="leftAlone ss-htmleditorfield-file embed" style="width: 839px;"> 359 <iframe src="https://player.vimeo.com/video/900861702?app_id=122963" width="839" height="473" frameborder="0" allow="autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share" referrerpolicy="strict-origin-when-cross-origin" title="Video about T1D and Early Check Screening - English"></iframe> 360 361</div> 362 363<h3 class="main__head"><a id="Criteria"></a>How did Early Check select the conditions to include?</h3> 364<p><span class="NormalTextRun SCXW102475505 BCX9">Our team developed a set of guidelines for reviewing and selecting health conditions for screening by Early </span><span class="NormalTextRun SpellingErrorV2Themed SCXW102475505 BCX9">Check. </span><span class="NormalTextRun SpellingErrorV2Themed SCXW102475505 BCX9">For</span><span class="NormalTextRun SCXW102475505 BCX9"> these </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW102475505 BCX9">conditions,</span></p> 365<ul> 366<li><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW20236883 BCX9">signs</span><span class="NormalTextRun SCXW20236883 BCX9"> and symptoms</span> <span class="NormalTextRun SCXW20236883 BCX9">usually begin in </span><span class="NormalTextRun SCXW20236883 BCX9">early </span><span class="NormalTextRun SCXW20236883 BCX9">childhood,</span></li> 367<li><span class="TextRun SCXW8574020 BCX9" data-contrast="auto"><span class="NormalTextRun SCXW8574020 BCX9">s</span><span class="NormalTextRun SCXW8574020 BCX9">upport services</span><span class="NormalTextRun SCXW8574020 BCX9">, treatments in development, </span><span class="NormalTextRun SCXW8574020 BCX9">and/</span><span class="NormalTextRun SCXW8574020 BCX9">or approved tr</span><span class="NormalTextRun SCXW8574020 BCX9">e</span><span class="NormalTextRun SCXW8574020 BCX9">atments are </span><span class="NormalTextRun SCXW8574020 BCX9">available </span><span class="NormalTextRun SCXW8574020 BCX9">for affected children,</span></span></li> 368<li><span class="TextRun SCXW159567165 BCX9" data-contrast="auto"><span class="NormalTextRun SpellingErrorV2Themed SCXW159567165 BCX9">treatments</span><span class="NormalTextRun SCXW159567165 BCX9"> may be more effective when </span><span class="NormalTextRun SCXW159567165 BCX9">started</span> <span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW159567165 BCX9">very </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW159567165 BCX9">early</span><span class="NormalTextRun SCXW159567165 BCX9"> in the disease course,</span></span></li> 369<li>
369early identification would likely lead to an overall benefit for babies or families.</li> 370</ul> 371<p><span class="TextRun SCXW229892129 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW229892129 BCX0"><span class="TextRun SCXW86421066 BCX9" data-contrast="auto"><span class="NormalTextRun SCXW86421066 BCX9">Over time, </span><span class="NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW86421066 BCX9">Early</span><span class="NormalTextRun SCXW86421066 BCX9"> Check added more conditions. </span><span class="NormalTextRun SCXW86421066 BCX9">We</span><span class="NormalTextRun SCXW86421066 BCX9"> drew on our guidelines, the advice from our board of expert advisors, and the most up-to-date scientific evidence to find conditions that fit with the goals of Early Check.</span></span></span></span></p> 372<h3 class="main__head secondary__head tertiary__head">How did we decide which genes and conditions to include in Group 1 and Group 2?</h3> 373<p><span class="TextRun SCXW229892129 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW229892129 BCX0"><div class="accordion mb-3 accordionOne" id="accordion-10"><div class="accordion-item"> 374 <h6 class="accordion-header" id="flush-heading-Group1Framework"> 375 <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-29" aria-expanded="false" aria-controls="flush-29">Group 1 Framework</button> 376 </h6> 377 <div id="flush-29" class="accordion-collapse collapse" aria-labelledby="flush-heading-Group1Framework" data-bs-parent="#accordion-10"> 378 <div class="accordion-body"> 379 <p></p><p><strong>There are two ways a condition could be included in Group 1.</strong></p><ol> 380<li data-leveltext="%1." data-font="Calibri" data-listid="47" data-list-defn-props="{"335552541":0,"335559684":-1,"335559685":720,"335559991":360,"469769242":[65533,0],"469777803":"left","469777804":"%1.","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span>There are things a doctor can do (treatments) to improve the health of a child with the condition. We must know enough about the treatments to know that they work well for most children. The treatments need to start early in life, by the time a child is 2 years old.<br><br><strong>OR</strong><br></span><span data-ccp-props="{"134233118":true,"201341983":0,"335559739":160,"335559740":259}"> </span></li> 381<li data-leveltext="%1." data-font="Calibri" data-listid="47" data-list-defn-props="{"335552541":0,"335559684":-1,"335559685":720,"335559991":360,"469769242":[65533,0],"469777803":"left","469777804":"%1.","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span>The condition is screened for by standard newborn screening. Babies would be screened for these conditions twice â once by the state and once by Early Check - using different screening methods.</span></li> 382</ol> 383 </div> 384 </div> 385 </div></div></span></span></p> 386<p><span class="TextRun SCXW229892129 BCX0" data-contrast="auto"><span class="NormalTextRun SCXW229892129 BCX0"><div class="accordion mb-3 accordionOne" id="accordion-11"><div class="accordion-item"> 387 <h6 class="accordion-header" id="flush-heading-Group2Framework"> 388 <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-30" aria-expanded="false" aria-controls="flush-30">Group 2 Framework</button> 389 </h6> 390 <div id="flush-30" class="accordion-collapse collapse" aria-labelledby="flush-heading-Group2Framework" data-bs-parent="#accordion-11"> 391 <div class="accordion-body"> 392 <p></p><p><strong>There are two ways a condition could be included in Group 2.</strong></p><ol> 393<li data-leveltext="%1." data-font="Calibri" data-listid="47" data-list-defn-props="{"335552541":0,"335559684":-1,"335559685":720,"335559991":360,"469769242":[65533,0],"469777803":"left","469777804":"%1.","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="3" data-aria-level="1"><span>There are things a doctor can do (treatments) to improve the health of a child with the condition. The treatments may not make as much of a health improvement as those in Group 1. The treatments may be new or may have been given to fewer children with the condition, so we know less about how well they work. The treatments need to start early in life, by the time a child is 2 years old.<br><br><strong>OR</strong><br></span><span data-ccp-props="{"134233118":true,"201341983":0,"335559739":160,"335559740":259}"> </span></li> 394<li data-leveltext="%1." data-font="Calibri" data-listid="47" data-list-defn-props="{"335552541":0,"335559684":-1,"335559685":720,"335559991":360,"469769242":[65533,0],"469777803":"left","469777804":"%1.","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="4" data-aria-level="1"><span>Conditions without treatments can be included if signs of the conditions usually show up in children by the time a child is 2 years old and there are studies going on now that may result in new treatments in the future.</span></li> 395</ol> 396 </div> 397 </div> 398 </div></div></span></span></p> 399<p> </p> 400<p><span class="TextRun SCXW229892129 BCX0" style="color: #005663;" data-contrast="auto"><span class="NormalTextRun SCXW229892129 BCX0"><strong><a style="color: #005663;" rel="noopener" href="/assets/Uploads/Conditions-Tested/Figure1.pdf" target="_blank">Here</a> is our framework for inclusion.</strong></span></span></p> 401<p> </p> 402<div class="row align-items-center" style="background: #f9e2c5; font-style: italic; margin-bottom: 20px; margin-top: 20px; padding-bottom: 15px; padding-top: 15px; text-align: right; padding-right: 15px;"> 403<div class="col-9"> 404<p>"There are many health conditions that impact young children that are currently not screened for during standard newborn screening. We hope that, through Early Check, we can show that screening for these conditions is possible and leads to benefits for children and their parents."</p> 405<p>â Heidi Cope, MS, CGC</p> 406</div> 407<div class="col-3"><img src="/assets/Uploads/Who-We-Are-Headshots/Cope_Heidi_headshot.jpg" alt="Heidi Cope" width="200" class="center ss-htmleditorfield-file image" title="Heidi Cope"></div> 408</div> 409</div> 410 411 </div> 412 <aside class="col-12 col-lg-4 mt-5 mt-md-0"> 413 414 415 <div 416 417 class="widget 418 419 widget-ec-panel"> 420 <div class="card card2 mb-3"> 421 <div class="bg-secondary card-header widget__head">
422 <span class="text-center text-dark mb-0">Conditions Screened by Early Check</span> 423 </div> 424 <div class="card-body"> 425 426 <div class="row mt-3"> 427 <div class="col-3 text-center"> 428 <img src="https://earlycheck.org/assets/Uploads/widgets/ecpanel/foot_red_whiteBG_SM.png" class="img-fluid"> 429 </div> 430 <div class="col-9"> 431 432 <h6 class="homepage__ec-panel__item__head">Group 1</h6> 433 434 <div class="row"> 435<div class="col-12 col-lg-10"> 436<p>Rare conditions that are<span> </span><em><u>treatable</u></em>, meaning that early treatment can prevent the most serious symptoms.</p> 437<p><a rel="noopener" href="/assets/Uploads/Gene-Condition-Lists/ENG_G1_Jan2025_14920_Early_Check_NC_Gene_List.pdf" target="_blank">Here's a list of genes and conditions included in Group 1.</a></p> 438</div> 439</div> 440 </div> 441 </div> 442 443 <div class="row mt-3"> 444 <div class="col-3 text-center"> 445 <img src="https://earlycheck.org/assets/Uploads/widgets/ecpanel/foot_yellow_whiteBG_SM.png" class="img-fluid"> 446 </div> 447 <div class="col-9"> 448 449 <h6 class="homepage__ec-panel__item__head">Optional Group 2</h6> 450 451 <div class="row"> 452<div class="col-12 col-lg-10"> 453<p>Rare conditions that have<span> </span><em><u>potential treatments</u></em><u>,</u><span> </span>meaning that treatments may not be able to prevent the most serious symptoms or that new treatments are still being studied.</p> 454<p><a rel="noopener" href="/assets/Uploads/Gene-Condition-Lists/ENG_G2_Jan2025_14920_Early_Check_NC_Gene_List.pdf" target="_blank">Here's a list of genes and conditions included in Group 2. </a></p> 455</div> 456</div> 457 </div> 458 </div> 459 460 <div class="row mt-3"> 461 <div class="col-3 text-center"> 462 <img src="https://earlycheck.org/assets/Uploads/widgets/ecpanel/foot_blue_whiteBG_SM.png" class="img-fluid"> 463 </div> 464 <div class="col-9"> 465 466 <h6 class="homepage__ec-panel__item__head">Optional Group 3</h6> 467 468 <p><em><u>Risk for Type 1 Diabetes</u></em><span>, a common childhood disease that is </span><em><u>treatable</u></em><span>. (<em>Note: Type 1 Diabetes is </em></span><em><u>not</u></em><span><em> the same as type 2 diabetes, which is more common in adults</em>.)</span></p><p> </p> 469 </div> 470 </div> 471 472 </div> 473 474 475 </div> 476 477 478 </aside> 479 480 </div> 481 </div> 482 </main> 483 </span> 484 485 486 <footer class="container-fluid"> 487 488 489 490 <div class="container footer__middle text-center footer__middle--no-top" 491 492 </div> 493 494 <div class="container"> 495 <div class="row align-items-between align-items-lg-center"> 496 <div class="col-12 col-md-4 col-lg-2 text-center"> 497 <p><strong class="text-primary">Led By</strong></p> 498 <a href="https://rti.org" target="_blank" rel="noopener"><img src="/themes/earlycheck/img/dist/rti-logo.png" alt="RTI International logo" class="footer__logos w-md-100 mb-5 mb-lg-3"></a> 499 </div> 500 501 <div class="col-12 col-md-8 col-lg-4 text-center"> 502 <p><strong class="text-primary">With Partners</strong></p> 503 <div class="row"> 504 <div class="col-12 col-md-6 col-lg-6"><a href="https://www.ncdhhs.gov/" target="_blank" rel="noopener"><img src="/themes/earlycheck/img/dist/ncslph-logo.png" alt="NC State Laboratory of Public Health logo" class="footer__logos w-md-100 mb-5 mb-lg-3"></a></div> 505 <div class="col-12 col-md-6 col-lg-6"><a href="http://www.unc.edu/" target="_blank" rel="noopener"><img src="/themes/earlycheck/img/dist/unc-logo.png" alt="UNC logo" class="footer__logos w-md-100 mb-5 mb-lg-3"></a></div> 506 </div> 507 </div> 508 <div class="col-12 col-lg-3 text-center"> 509 510 <a href="mailto:[email protected]" class="link-primary small d-block mb-2"><i data-feather="mail"></i> [email protected]</a> 511 512 513 <a href="tel:+1 (866) 881-2715" class="link-primary small d-block"><i data-feather="phone"></i> +1 (866) 881-2715</a> 514 515 </div> 516 <div class="col-12 col-lg-3 text-center"> 517 <a href="/contact-us/" class="link-primary small">Contact Us</a> 518 </div> 519 </div> 520 <div class="row align-items-between align-items-lg-center"> 521 <div class="col-12 text-center"> 522 <a href="https://www.linkedin.com/company/early-check-research-program/" class="footer__social-link link-primary small" title="Early Check on LinkedIn" target="_blank" rel="noopener"><i data-feather="linkedin"></i></a> 523 <a href="https://www.instagram.com/earlychecknc/" class="footer__social-link link-primary small" title="Early Check on Instagram" target="_blank" rel="noopener"><i data-feather="instagram"></i></a> 524 <a href="https://www.facebook.com/earlycheck/" class="footer__social-link link-primary small" title="Early Check on Facebook" target="_blank" rel="noopener"><i data-feather="facebook"></i></a> 525 </div> 526 </div> 527 </div> 528 </div> 529</footer> 530<div class="container-fluid bg-secondary py-1"> 531 <div class="container"> 532 <div class="row"> 533 <div class="col-12"> 534 <nav class="nav justify-content-center"> 535 536 <a class="nav-link link-dark" href="/home-2/" title="What is Early Check?"> 537 What is Early Check? 538 </a> 539 540 <a class="nav-link link-dark" href="/how-early-check-wor
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