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xl:text-pretty body-small">Publicado em <!-- -->19 de setembro de 2026 à s<!-- --> <!-- -->05h32<!-- -->.</p></div><a href="https://google.com/preferences/source?q=exame.com" target="_blank" rel="noopener noreferrer" aria-label="Priorizar Exame nos meus resultados Google" class="bg-white inline-flex items-center gap-2 rounded-1 border border-solid border-[#747775] px-4 py-2 no-underline mt-2 lg:mt-0"><svg xmlns="http://www.w3.org/2000/svg" width="2443" height="2500" preserveAspectRatio="xMidYMid" viewBox="0 0 256 262" class="h-5 w-5 shrink-0"><path d="M255.878,133.451c0-10.734-.871-18.567-2.756-26.69H130.55v48.448h71.947c-1.45,12.04-9.283,30.172-26.69,42.356l-.244,1.622,38.755,30.023,2.685.268c24.659-22.774,38.875-56.282,38.875-96.027" fill="#4285F4"></path><path d="M130.55,261.1c35.248,0,64.839-11.605,86.453-31.622l-41.196-31.913c-11.024,7.688-25.82,13.055-45.257,13.055-34.523,0-63.824-22.773-74.269-54.25l-1.531.13-40.298,31.187-.527,1.465C35.393,231.798,79.49,261.1,130.55,261.1" fill="#34A853"></path><path d="M56.281,156.37c-2.756-8.123-4.351-16.827-4.351-25.82,0-8.994,1.595-17.697,4.206-25.82l-.073-1.73L15.26,71.312l-1.335.635C5.077,89.644,0,109.517,0,130.55s5.077,40.905,13.925,58.602l42.356-32.782" fill="#FBBC05"></path><path d="M130.55,50.479c24.514,0,41.05,10.589,50.479,19.438l36.844-35.974C195.245,12.91,165.798,0,130.55,0,79.49,0,35.393,29.301,13.925,71.947l42.211,32.783c10.59-31.477,39.891-54.251,74.414-54.251" fill="#EB4335"></path></svg><span class="whitespace-nowrap text-sm font-bold text-[#1f1f1f]">Priorizar nos meus resultados Google</span></a></div><div><section class="relative grid gap-6"><div class="flex items-center justify-between border border-x-0 border-solid border-colors-divider py-4 dark:border-colors-dark-divider"><div><span class="m-0 p-0 text-colors-text xl:text-pretty headline-extra-small mr-1 inline dark:text-colors-background lg:hidden">Tudo sobre</span><span class="m-0 p-0 text-colors-text xl:text-pretty headline-extra-small mr-1 hidden dark:text-colors-background lg:inline-block">Acompanhe tudo sobre</span><span class="m-0 p-0 text-colors-text xl:text-pretty headline-extra-small inline dark:text-colors-background">Ozempic</span></div><a class="items-center rounded-6 cursor-pointer flex justify-center py-3 px-6 border-solid border no-underline transition-all ease-in select-none bg-colors-background border-colors-divider [&>span]:text-colors-primary hover:bg-colors-exame10 active:border-colors-primary" aria-label="Saiba mais" href="https://exame.com/arquivo/ozempic/"><span class="m-0 p-0 text-colors-text xl:text-pretty label-large whitespace-nowrap">Saiba mais</span></a></div><div class="section-item relative w-full"><div class="relative grid" id="news-body"><div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Uma análise com <strong>inteligência artificial</strong> de mais de 400 mil postagens no Reddit identificou sintomas pouco relatados por usuários de medicamentos como <strong>Ozempic, Wegovy, Mounjaro </strong>e<strong> Zepbound</strong>. Entre eles estão alterações menstruais, calafrios, ondas de calor e fadiga.</p><div class="exm_paragraph_end" style="display:none"></div> 6<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Os resultados fazem parte de um estudo conduzido por pesquisadores da Universidade da Pensilvânia e publicado na revista <em><a href="https://www.nature.com/articles/s44360-026-00108-y" class="exm-hyperlink">Nature Health</a></em>. A equipe analisou mais de cinco anos de publicações feitas por quase 70 mil usuários do <strong>Reddit</strong>. Os pesquisadores concentraram atenção em relatos menos representados em estudos clÃnicos e informações regulatórias.</p><div class="exm_paragraph_end" style="display:none"></div> 7<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">
7Os medicamentos avaliados incluÃram <a href="https://exame.com/ciencia/novo-efeito-do-ozempic-estudo-encontra-relacao-com-menos-crises-de-asma/" class="exm-hyperlink"><strong>semaglutida</strong></a>, princÃpio ativo de<strong><a href="https://exame.com/ciencia/como-o-ozempic-mantem-a-perda-de-peso-cientistas-encontram-nova-pista/" class="exm-hyperlink"> Ozempic</a>, Wegovy </strong>e<strong> Rybelsus</strong>, e <strong>tirzepatida</strong>, presente em <a href="https://exame.com/invest/mercados/em-um-ano-no-brasil-mounjaro-tem-3-milhoes-de-usuarios-e-soma-r-135-bi-em-vendas/" class="exm-hyperlink"><strong>Mounjaro</strong></a> e <strong>Zepbound</strong>.</p><div class="exm_paragraph_end" style="display:none"></div> 8<div class="exm_h2_start" style="display:none"></div><h2 class="m-0 p-0 xl:text-pretty headline-small py-3 text-colors-text dark:text-colors-background">Alterações menstruais chamaram atenção dos pesquisadores</h2><div class="exm_h2_end" style="display:none"></div> 9<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Cerca de <strong>44%</strong> dos usuários analisados relataram pelo menos um efeito colateral. Os <a href="https://exame.com/ciencia/ozempic-e-mounjaro-quem-pode-usar-canetas-emagrecedoras/" class="exm-hyperlink"><strong>problemas gastrointestinais</strong></a> foram os mais frequentes, resultado compatÃvel com sintomas já conhecidos desses medicamentos, como <strong>náusea</strong> e outras alterações digestivas.</p><div class="exm_paragraph_end" style="display:none"></div> 10<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Quase 4% dos usuários que mencionaram <strong>efeitos colaterais</strong> relataram sintomas reprodutivos, proporção ainda maior quando consideradas apenas mulheres. Entre os relatos estavam sangramentos entre<strong> perÃodos <a href="https://exame.com/ciencia/estudo-investiga-como-o-ciclo-menstrual-pode-influenciar-efeito-das-vacinas/" class="exm-hyperlink">menstruais</a>, fluxo intenso </strong>e<strong> ciclos irregulares</strong>.</p><div class="exm_paragraph_end" style="display:none"></div> 11<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Segundo Neil Sehgal, primeiro autor do estudo e doutorando em Ciência da Computação e Informação, esse padrão não permite afirmar que os medicamentos sejam responsáveis pelas alterações, mas indica um sinal que merece ser investigado.</p><div class="exm_paragraph_end" style="display:none"></div> 12<div class="exm_h2_start" style="display:none"></div><h2 class="m-0 p-0 xl:text-pretty headline-small py-3 text-colors-text dark:text-colors-background">Calafrios e ondas de calor também apareceram nos relatos</h2><div class="exm_h2_end" style="display:none"></div> 13<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Outro grupo de sintomas observado estava relacionado à <strong>regulação da <a href="https://exame.com/ciencia/calor-a-noite-faz-mais-mal-do-que-parece-entenda-os-riscos-para-a-saude/" class="exm-hyperlink">temperatura corporal</a></strong>. Usuários descreveram calafrios, sensação incomum de frio, ondas de calor e sintomas semelhantes aos de febre.</p><div class="exm_paragraph_end" style="display:none"></div> 14<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Os pesquisadores destacam que uma possÃvel explicação a ser investigada envolve o <strong>hipotálamo</strong>, região do cérebro que participa da regulação da<a href="https://exame.com/ciencia/novo-comprimido-para-perda-de-peso-age-na-gordura-nao-no-apetite/" class="exm-hyperlink"><strong> fome</strong></a>, dos hormônios, da reprodução e da temperatura corporal.</p><div class="exm_paragraph_end" style="display:none"></div> 15<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Jena Shaw Tronieri, pesquisadora do Centro de Distúrbios Alimentares e de Peso da Universidade da Pensilvânia e coautora do trabalho, afirma que essa possÃvel relação biológica não demonstra que os medicamentos tenham causado os sintomas. Para a equipe, os relatos apenas reforçam a necessidade de estudar alterações menstruais e de temperatura de forma mais sistemática.</p><div class="exm_paragraph_end" style="display:none"></div> 16<div class="exm_h2_start" style="display:none"></div><h2 class="m-0 p-0 xl:text-pretty headline-small py-3 text-colors-text dark:text-colors-background">Fadiga foi uma das queixas mais frequentes</h2><div class="exm_h2_end" style="display:none"></div> 17<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">A <a href="https://exame.com/ciencia/cansaco-constante-a-causa-pode-estar-na-falta-de-duas-vitaminas/" class="exm-hyperlink"><strong>fadiga</strong></a>
17 também chamou atenção na análise e apareceu como a segunda queixa mais frequente nas postagens avaliadas. Segundo os pesquisadores, relativamente poucos ensaios clÃnicos registraram fadiga em frequência suficiente para atingir os critérios tradicionais de notificação.</p><div class="exm_paragraph_end" style="display:none"></div> 18<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Esse contraste é um dos exemplos de como relatos espontâneos em redes sociais podem revelar experiências que nem sempre aparecem com destaque em pesquisas clÃnicas ou sistemas formais de monitoramento. No entanto, a pesquisa destaca, porém, que isso não significa que essas plataformas substituam estudos controlados.</p><div class="exm_paragraph_end" style="display:none"></div> 19<div class="exm_h2_start" style="display:none"></div><h2 class="m-0 p-0 xl:text-pretty headline-small py-3 text-colors-text dark:text-colors-background">IA analisou linguagem cotidiana dos pacientes</h2><div class="exm_h2_end" style="display:none"></div> 20<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Um dos desafios da pesquisa foi transformar a maneira informal como os usuários descrevem sintomas em categorias médicas comparáveis. Uma pessoa pode escrever que sente frio constantemente, por exemplo, enquanto outra relata<strong> calafrios</strong>. Na prática clÃnica, essas descrições podem ser agrupadas em uma mesma categoria de sintomas.</p><div class="exm_paragraph_end" style="display:none"></div> 21<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Para fazer essa correspondência em grande escala, a equipe utilizou grandes modelos de linguagem, como <a href="https://exame.com/inteligencia-artificial/gpt-6-astra-como-aproveitar-ao-maximo-o-potencial-do-novo-lancamento-da-openai/" class="exm-hyperlink"><strong>GPT</strong></a> e <a href="https://exame.com/inteligencia-artificial/google-lanca-gemini-flash-3-8-e-chama-modelo-de-o-mais-inteligente-ate-agora/" class="exm-hyperlink"><strong>Gemini</strong></a>, para processar e organizar os textos.</p><div class="exm_paragraph_end" style="display:none"></div> 22<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Os sintomas foram relacionados a categorias padronizadas do Dicionário Médico para Atividades Regulatórias (MedDRA), sistema usado para classificar condições médicas, sintomas e eventos adversos.</p><div class="exm_paragraph_end" style="display:none"></div> 23<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Os pesquisadores chamam a abordagem de "escuta social computacional", na qual <strong><a href="https://exame.com/inteligencia-artificial/quase-ninguem-faz-isso-10-tecnicas-para-fazer-qualquer-ia-responder-muito-melhor/" class="exm-hyperlink">métodos computacionais</a></strong> procuram padrões em grandes volumes de conversas sobre saúde.</p><div class="exm_paragraph_end" style="display:none"></div> 24<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Apesar disso, a equipe reconhece limitações importantes. Os usuários do <a href="https://exame.com/inteligencia-artificial/ele-criou-um-forum-no-reddit-para-sabotar-o-negocio-bilionario-da-ia-no-google/" class="exm-hyperlink"><strong>Reddit</strong> </a>não representam toda a população que utiliza medicamentos <a href="https://exame.com/ciencia/ozempic-e-wegovy-podem-ter-efeito-inesperado-no-transtorno-bipolar-aponta-estudo/" class="exm-hyperlink"><strong>GLP-1</strong></a>. Segundo o estudo, eles tendem a ser mais jovens, incluem proporcionalmente mais homens e estão concentrados principalmente nos Estados Unidos.</p><div class="exm_paragraph_end" style="display:none"></div> 25<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Além disso, as postagens são relatos espontâneos e não registros médicos verificados. Ainda assim, vários sintomas encontrados pela ferramenta correspondiam a efeitos já conhecidos da semaglutida e da tirzepatida, o que, segundo os autores, indica que o método conseguiu detectar padrões reais presentes nas conversas.</p><div class="exm_paragraph_end" style="display:none"></div> 26<div class="exm_h2_start" style="display:none"></div><h2 class="m-0 p-0 xl:text-pretty headline-small py-3 text-colors-text dark:text-colors-background">
26Redes sociais podem funcionar como sinal precoce</h2><div class="exm_h2_end" style="display:none"></div> 27<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Os pesquisadores defendem que a análise de <strong>conversas online</strong> pode complementar os métodos tradicionais de acompanhamento da segurança de medicamentos.</p><div class="exm_paragraph_end" style="display:none"></div> 28<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Ensaios clÃnicos continuam sendo essenciais para determinar eficácia e segurança, mas envolvem grupos controlados e não conseguem necessariamente registrar todas as experiências que surgem quando milhões de pessoas passam a utilizar um medicamento.</p><div class="exm_paragraph_end" style="display:none"></div> 29<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">Nas redes sociais, pacientes também podem comentar <strong>sintomas</strong> que nunca chegam a ser relatados formalmente a médicos, fabricantes ou órgãos reguladores.</p><div class="exm_paragraph_end" style="display:none"></div> 30<div class="exm_paragraph_start" style="display:none"></div><p class="m-0 p-0 xl:text-pretty body-extra-large overflow-hidden py-3 text-colors-text dark:text-colors-background lg:py-4 [&_a]:text-colors-exame90 [&_a]:underline">A equipe agora pretende ampliar a análise para outras plataformas e para comunidades que não utilizam apenas o inglês. O objetivo é verificar se os mesmos padrões aparecem em diferentes populações e entender se os sinais identificados no Reddit também são observados entre outros grupos de usuários de medicamentos GLP-1.</p><div class="exm_paragraph_end" style="display:none"></div> 31</div></div><div><span class="m-0 p-0 xl:text-pretty headline-extra-small mr-2 text-colors-placeholder">Acompanhe tudo sobre:</span><a class="m-0 p-0 xl:text-pretty headline-extra-small comma-separator inline-block text-colors-placeholder hover:underline" href="https://exame.com/noticias-sobre/inteligencia-artificial/" target="_blank">Inteligência artificial</a><a class="m-0 p-0 xl:text-pretty headline-extra-small comma-separator inline-block text-colors-placeholder hover:underline" href="https://exame.com/noticias-sobre/ozempic/" target="_blank">Ozempic</a></div></section></div><div class="-mt-6 flex flex-col gap-6 lg:mt-7" data-cy="more-recent-category"><div class="z-1 m-0 flex flex-row justify-center transition-all duration-[900ms] ease-in relative"><div class="flex flex-col"><div class="min-h-[50px] rounded-3 transition-all duration-[900ms] ease-in relative top-0 ad-pos-4 h-[250px] lg:h-[90px]"></div></div></div><div class="relative col-span-12 grid" data-cy="section-divider"><div class="flex w-full items-center mb-6"><h2 class="m-0 p-0 text-colors-text xl:text-pretty headline-small dark:text-colors-dark-text">Mais de Ciência</h2><div class="ml-6 mt-1 flex-1 border-0 border-t border-solid border-colors-divider dark:border-colors-dark-divider"></div></div><div class="flex w-full flex-col"><div class="flex-col flex max-h-full relative no-underline" data-cy="card-container"><div class="relative flex flex-grow flex-col md:flex-row gap-4"><a href="https://exame.com/ciencia/cientistas-descobrem-nova-camada-do-alzheimer-escondida-no-dna/" class="hidden md:flex"><figure class="relative m-0 shrink-0 p-0 h-[203px] [&>img]:aspect-[3/2] w-[305px]"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27305%27%20height=%27203%27/%3e"/></span>
31<img alt="Cientistas descobrem nova 'camada' do Alzheimer escondida no DNA" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" class="placeholder-image h-auto w-full object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Cientistas descobrem nova 'camada' do Alzheimer escondida no DNA" loading="lazy" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="placeholder-image h-auto w-full object-cover" src="https://classic.exame.com/wp-content/uploads/2026/09/alzheimer.jpg?ims=305x/filters:quality(85):format(webp)"/></noscript></span></figure></a><div><a href="https://exame.com/ciencia/cientistas-descobrem-nova-camada-do-alzheimer-escondida-no-dna/"><h3 class="m-0 p-0 text-colors-text xl:text-pretty hover:underline dark:text-colors-dark-text headline-small">Cientistas descobrem nova 'camada' do Alzheimer escondida no DNA</h3></a><p class="m-0 p-0 text-colors-text xl:text-pretty line-clamp-3 dark:text-colors-dark-text title-medium mt-2 hidden md:flex">Estudo identificou mudanças na organização tridimensional do genoma em células cerebrais e relacionou essas alterações à atividade dos genes</p></div></div></div><span class="w-full h-[1px] bg-colors-divider dark:bg-colors-dark-divider flex my-6"></span><div class="flex-col flex max-h-full relative no-underline" data-cy="card-container"><div class="relative flex flex-grow flex-col md:flex-row gap-4"><a href="https://exame.com/ciencia/por-que-venus-nao-tem-lua-planeta-pode-ter-engolido-seu-satelite/" class="hidden md:flex"><figure class="relative m-0 shrink-0 p-0 h-[203px] [&>img]:aspect-[3/2] w-[305px]"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27305%27%20height=%27203%27/%3e"/></span><img alt="Por que Vênus não tem lua? Planeta pode ter 'engolido' seu satélite" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" class="placeholder-image h-auto w-full object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="Por que Vênus não tem lua? Planeta pode ter 'engolido' seu satélite" loading="lazy" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="placeholder-image h-auto w-full object-cover" src="https://classic.exame.com/wp-content/uploads/2026/09/venus.jpg?ims=305x/filters:quality(85):format(webp)"/></noscript></span></figure></a><div><a href="https://exame.com/ciencia/por-que-venus-nao-tem-lua-planeta-pode-ter-engolido-seu-satelite/"><h3 class="m-0 p-0 text-colors-text xl:text-pretty hover:underline dark:text-colors-dark-text headline-small">Por que Vênus não tem lua? Planeta pode ter 'engolido' seu satélite</h3></a><p class="m-0 p-0 text-colors-text xl:text-pretty line-clamp-3 dark:text-colors-dark-text title-medium mt
31-2 hidden md:flex">Simulações indicam que a rotação lenta poderia alterar a órbita de um antigo satélite natural até provocar uma colisão</p></div></div></div><span class="w-full h-[1px] bg-colors-divider dark:bg-colors-dark-divider flex my-6"></span><div class="flex-col flex max-h-full relative no-underline" data-cy="card-container"><div class="relative flex flex-grow flex-col md:flex-row gap-4"><a href="https://exame.com/ciencia/laticinios-aumentam-o-risco-de-cancer-de-prostata-o-que-mostram-os-estudos/" class="hidden md:flex"><figure class="relative m-0 shrink-0 p-0 h-[203px] [&>img]:aspect-[3/2] w-[305px]"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%27305%27%20height=%27203%27/%3e"/></span><img alt="LaticÃnios aumentam o risco de câncer de próstata? 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O que mostram os estudos" loading="lazy" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="placeholder-image h-auto w-full object-cover" src="https://classic.exame.com/wp-content/uploads/2026/06/Leite.jpg?ims=305x/filters:quality(85):format(webp)"/></noscript></span></figure></a><div><a href="https://exame.com/ciencia/laticinios-aumentam-o-risco-de-cancer-de-prostata-o-que-mostram-os-estudos/"><h3 class="m-0 p-0 text-colors-text xl:text-pretty hover:underline dark:text-colors-dark-text headline-small">LaticÃnios aumentam o risco de câncer de próstata? 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31-2 hidden md:flex">Análise de dados entre 1979 e 2024 mostra que tempestades sucessivas prolongam os danos e dificultam a recuperação do gelo marinho</p></div></div></div></div></div><div class="z-1 m-0 flex flex-row justify-center transition-all duration-[900ms] ease-in relative"><div class="flex flex-col"><div class="min-h-[50px] rounded-3 transition-all duration-[900ms] ease-in relative top-0 ad-pos-5 h-[250px] lg:h-[90px]"></div></div></div></div></div><div class="col-span-12 relative hidden 2xl:col-span-1 2xl:block"><div></div></div><aside class="col-span-12 relative xl:col-span-4 2xl:col-span-3"><div class="z-1 m-0 flex flex-row justify-center transition-all duration-[900ms] ease-in relative"><div class="flex flex-col"><div class="min-h-[50px] rounded-3 transition-all duration-[900ms] ease-in relative top-0 ad-pos-6 mb-6 h-[250px]"></div></div></div><section data-cy="most-read" class="flex w-full flex-col mb-6"><h2 class="m-0 p-0 text-colors-text xl:text-pretty headline-small dark:text-colors-background">Mais lidas</h2><div class="mt-6 flex w-full flex-col gap-4"><div class="flex items-start gap-4 border-0 border-b border-solid border-colors-divider pb-4 dark:border-colors-dark-divider"><p class="m-0 p-0 xl:text-pretty title-large text-colors-placeholder">01</p><a class="m-0 p-0 text-colors-text xl:text-pretty label-large flex-1 hover:underline dark:text-colors-background" href="https://exame.com/ciencia/cientistas-contestam-regra-de-quimica-ensinada-ha-quase-100-anos/">Cientistas contestam regra de quÃmica ensinada há quase 100 anos</a></div><div class="flex items-start gap-4 border-0 border-b border-solid border-colors-divider pb-4 dark:border-colors-dark-divider"><p class="m-0 p-0 xl:text-pretty title-large text-colors-placeholder">02</p><a class="m-0 p-0 text-colors-text xl:text-pretty label-large flex-1 hover:underline dark:text-colors-background" href="https://exame.com/ciencia/lua-da-colheita-ilumina-o-ceu-em-setembro-veja-data-e-horario-do-fenomeno/">Lua da Colheita ilumina o céu em setembro; veja data e horário do fenômeno</a></div><div class="flex items-start gap-4 border-0 border-b border-solid border-colors-divider pb-4 dark:border-colors-dark-divider"><p class="m-0 p-0 xl:text-pretty title-large text-colors-placeholder">03</p><a class="m-0 p-0 text-colors-text xl:text-pretty label-large flex-1 hover:underline dark:text-colors-background" href="https://exame.com/ciencia/pilula-da-longevidade-para-caes-avanca-em-aprovacao-nos-eua/">âPÃlula da longevidadeâ para cães avança em aprovação nos EUA</a></div></div></section><div class="z-1 m-0 flex flex-row justify-center transition-all duration-[900ms] ease-in relative"><div class="flex flex-col"><div class="min-h-[50px] rounded-3 transition-all duration-[900ms] ease-in relative top-0 ad-pos-7 h-[250px] lg:h-[600px]"></div></div></div><div class="flex w-full flex-col rounded-3 border border-solid border-colors-divider px-6 py-8 dark:border-colors-dark-divider my-6" data-cy="whatsapp-subscription"><span class="flex w-fit rounded-1 p-1 bg-[#25D366] [&>p]:text-colors-background"><p class="m-0 p-0 text-colors-text xl:text-pretty uppercase label-small flex items-center gap-1 dark:text-colors-dark-text" href=""><svg xmlns="http://www.w3.org/2000/svg" focusable="false" aria-hidden="true" viewBox="0 0 24 24" width="24" height="24" stroke="currentColor" fill="currentColor" stroke-width="0" class="h-4 w-4 fill-colors-background"><path d="m0 0h24v24h-24z" fill="none"></path><path d="m2.004 22 1.352-4.968a9.954 9.954 0 0 1 -1.356-5.032c0-5.523 4.477-10 10-10s10 4.477 10 10-4.477 10-10 10a9.954 9.954 0 0 1 -5.03-1.355zm6.387-14.692a.961.961 0 0 0 -.371.1 1.293 1.293 0 0 0 -.294.228c-.12.113-.188.211-.261.306a2.729 2.729 0 0 0 -.565 1.678c.002.49.13.967.33 1.413.409.902 1.082 1.857 1.971 2.742.214.213.423.427.648.626a9.448 9.448 0 0 0 3.84 2.046l.569.087c.185.01.37-.004.556-.013a1.99 1.99 0 0 0 .833-.231c.166-.088.244-.132.383-.22 0 0 .043-.028.125-.09.135-.1.218-.171.33-.288.083-.086.155-.187.21-.302.078-.163.156-.474.188-.733.024-.198.017-.306.014-.373-.004-.107-.093-.218-.19-.265l-.582-.261s-.87-.379-1.401-.621a.498.498 0 0 0 -.177-.041.482.482
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31<script>self.__next_f.push([1,"\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eUma análise com \u003cstrong\u003einteligência artificial\u003c/strong\u003e de mais de 400 mil postagens no Reddit identificou sintomas pouco relatados por usuários de medicamentos como \u003cstrong\u003eOzempic, Wegovy, Mounjaro \u003c/strong\u003ee\u003cstrong\u003e Zepbound\u003c/strong\u003e. Entre eles estão alterações menstruais, calafrios, ondas de calor e fadiga.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs resultados fazem parte de um estudo conduzido por pesquisadores da Universidade da Pensilvânia e publicado na revista \u003cem\u003e\u003ca href=\"https://www.nature.com/articles/s44360-026-00108-y\" class=\"exm-hyperlink\"\u003eNature Health\u003c/a\u003e\u003c/em\u003e. A equipe analisou mais de cinco anos de publicações feitas por quase 70 mil usuários do \u003cstrong\u003eReddit\u003c/strong\u003e. Os pesquisadores concentraram atenção em relatos menos representados em estudos clÃnicos e informações regulatórias.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs medicamentos avaliados incluÃram \u003ca href=\"https://exame.com/ciencia/novo-efeito-do-ozempic-estudo-encontra-relacao-com-menos-crises-de-asma/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003esemaglutida\u003c/strong\u003e\u003c/a\u003e, princÃpio ativo de\u003cstrong\u003e\u003ca href=\"https://exame.com/ciencia/como-o-ozempic-mantem-a-perda-de-peso-cientistas-encontram-nova-pista/\" class=\"exm-hyperlink\"\u003e Ozempic\u003c/a\u003e, Wegovy \u003c/strong\u003ee\u003cstrong\u003e Rybelsus\u003c/strong\u003e, e \u003cstrong\u003etirzepatida\u003c/strong\u003e, presente em \u003ca href=\"https://exame.com/invest/mercados/em-um-ano-no-brasil-mounjaro-tem-3-milhoes-de-usuarios-e-soma-r-135-bi-em-vendas/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eMounjaro\u003c/strong\u003e\u003c/a\u003e e \u003cstrong\u003eZepbound\u003c/strong\u003e.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_h2_start\"\u003e\u003c/div\u003e\u003ch2\u003eAlterações menstruais chamaram atenção dos pesquisadores\u003c/h2\u003e\u003cdiv class=\"exm_h2_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eCerca de \u003cstrong\u003e44%\u003c/strong\u003e dos usuários analisados relataram pelo menos um efeito colateral. Os \u003ca href=\"https://exame.com/ciencia/ozempic-e-mounjaro-quem-pode-usar-canetas-emagrecedoras/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eproblemas gastrointestinais\u003c/strong\u003e\u003c/a\u003e foram os mais frequentes, resultado compatÃvel com sintomas já conhecidos desses medicamentos, como \u003cstrong\u003enáusea\u003c/strong\u003e e outras alterações digestivas.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eQuase 4% dos usuários que mencionaram \u003cstrong\u003eefeitos colaterais\u003c/strong\u003e relataram sintomas reprodutivos, proporção ainda maior quando consideradas apenas mulheres. Entre os relatos estavam sangramentos entre\u003cstrong\u003e perÃodos \u003ca href=\"https://exame.com/ciencia/estudo-investiga-como-o-ciclo-menstrual-pode-influenciar-efeito-das-vacinas/\" class=\"exm-hyperlink\"\u003emenstruais\u003c/a\u003e, fluxo intenso \u003c/strong\u003ee\u003cstrong\u003e ciclos irregulares\u003c/strong\u003e.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eSegundo Neil Sehgal, primeiro autor do estudo e doutorando em Ciência da Computação e Informação, esse padrão não permite afirmar que os medicamentos sejam responsáveis pelas alterações, mas indica um sinal que merece ser investigado.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_h2_start\"\u003e\u003c/div\u003e\u003ch2\u003eCalafrios e ondas de calor também apareceram nos relatos\u003c/h2\u003e\u003cdiv class=\"exm_h2_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOutro grupo de sintomas observado estava relacionado à \u003cstrong\u003eregulação da \u003ca href=\"https://exame.com/ciencia/calor-a-noite-faz-mais-mal-do-que-parece-entenda-os-riscos-para-a-saude/\" class=\"exm-hyperlink\"\u003etemperatura corporal\u003c/a\u003e\u003c/strong\u003e. Usuários descreveram calafrios, sensação incomum de frio, ondas de calor e sintomas semelhantes aos de febre.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs pesquisadores destacam que uma possÃvel explicação a ser investigada envolve o \u003cstrong\u003ehipotálamo\u003c/strong\u003e, região do cérebro que participa da regulação da\u003ca href=\"https://exame.com/ciencia/novo-comprimido-para-perda-de-peso-age-na-gordura-nao-no-apetite/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003e fome\u003c/strong\u003e\u003c/a\u003e, dos hormônios, da reprodução e da temperatura corporal.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eJena Shaw Tronieri, pesquisadora do Centro de Distúrbios Alimentares e de Peso da Universidade da Pensilvânia e coautora do trabalho, afirma que essa possÃvel relação biológica não demonstra que os medicamentos tenham causado os sintomas. Para a equipe, os relatos apenas reforçam a necessidade de estudar alterações menstruais e de temperatura de forma mais sistemática.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_h2_start\"\u003e\u003c/div\u003e\u003ch2\u003eFadiga foi uma das queixas mais frequentes\u003c/h2\u003e\u003cdiv class=\"exm_h2_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eA \u003ca href=\"https://exame.com/ciencia/cansaco-constante-a-causa-pode-estar-na-falta-de-duas-vitaminas/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003efadiga\u003c/strong\u003e\u003c/a\u003e também chamou atenção na análise e apareceu c
31omo a segunda queixa mais frequente nas postagens avaliadas. Segundo os pesquisadores, relativamente poucos ensaios clÃnicos registraram fadiga em frequência suficiente para atingir os critérios tradicionais de notificação.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eEsse contraste é um dos exemplos de como relatos espontâneos em redes sociais podem revelar experiências que nem sempre aparecem com destaque em pesquisas clÃnicas ou sistemas formais de monitoramento. No entanto, a pesquisa destaca, porém, que isso não significa que essas plataformas substituam estudos controlados.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_h2_start\"\u003e\u003c/div\u003e\u003ch2\u003eIA analisou linguagem cotidiana dos pacientes\u003c/h2\u003e\u003cdiv class=\"exm_h2_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eUm dos desafios da pesquisa foi transformar a maneira informal como os usuários descrevem sintomas em categorias médicas comparáveis. Uma pessoa pode escrever que sente frio constantemente, por exemplo, enquanto outra relata\u003cstrong\u003e calafrios\u003c/strong\u003e. Na prática clÃnica, essas descrições podem ser agrupadas em uma mesma categoria de sintomas.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003ePara fazer essa correspondência em grande escala, a equipe utilizou grandes modelos de linguagem, como \u003ca href=\"https://exame.com/inteligencia-artificial/gpt-6-astra-como-aproveitar-ao-maximo-o-potencial-do-novo-lancamento-da-openai/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eGPT\u003c/strong\u003e\u003c/a\u003e e \u003ca href=\"https://exame.com/inteligencia-artificial/google-lanca-gemini-flash-3-8-e-chama-modelo-de-o-mais-inteligente-ate-agora/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eGemini\u003c/strong\u003e\u003c/a\u003e, para processar e organizar os textos.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs sintomas foram relacionados a categorias padronizadas do Dicionário Médico para Atividades Regulatórias (MedDRA), sistema usado para classificar condições médicas, sintomas e eventos adversos.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs pesquisadores chamam a abordagem de \"escuta social computacional\", na qual \u003cstrong\u003e\u003ca href=\"https://exame.com/inteligencia-artificial/quase-ninguem-faz-isso-10-tecnicas-para-fazer-qualquer-ia-responder-muito-melhor/\" class=\"exm-hyperlink\"\u003emétodos computacionais\u003c/a\u003e\u003c/strong\u003e procuram padrões em grandes volumes de conversas sobre saúde.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eApesar disso, a equipe reconhece limitações importantes. Os usuários do \u003ca href=\"https://exame.com/inteligencia-artificial/ele-criou-um-forum-no-reddit-para-sabotar-o-negocio-bilionario-da-ia-no-google/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eReddit\u003c/strong\u003e \u003c/a\u003enão representam toda a população que utiliza medicamentos \u003ca href=\"https://exame.com/ciencia/ozempic-e-wegovy-podem-ter-efeito-inesperado-no-transtorno-bipolar-aponta-estudo/\" class=\"exm-hyperlink\"\u003e\u003cstrong\u003eGLP-1\u003c/strong\u003e\u003c/a\u003e. Segundo o estudo, eles tendem a ser mais jovens, incluem proporcionalmente mais homens e estão concentrados principalmente nos Estados Unidos.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eAlém disso, as postagens são relatos espontâneos e não registros médicos verificados. Ainda assim, vários sintomas encontrados pela ferramenta correspondiam a efeitos já conhecidos da semaglutida e da tirzepatida, o que, segundo os autores, indica que o método conseguiu detectar padrões reais presentes nas conversas.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_h2_start\"\u003e\u003c/div\u003e\u003ch2\u003eRedes sociais podem funcionar como sinal prec
31oce\u003c/h2\u003e\u003cdiv class=\"exm_h2_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eOs pesquisadores defendem que a análise de \u003cstrong\u003econversas online\u003c/strong\u003e pode complementar os métodos tradicionais de acompanhamento da segurança de medicamentos.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eEnsaios clÃnicos continuam sendo essenciais para determinar eficácia e segurança, mas envolvem grupos controlados e não conseguem necessariamente registrar todas as experiências que surgem quando milhões de pessoas passam a utilizar um medicamento.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eNas redes sociais, pacientes também podem comentar \u003cstrong\u003esintomas\u003c/strong\u003e que nunca chegam a ser relatados formalmente a médicos, fabricantes ou órgãos reguladores.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n\u003cdiv class=\"exm_paragraph_start\"\u003e\u003c/div\u003e\u003cp\u003eA equipe agora pretende ampliar a análise para outras plataformas e para comunidades que não utilizam apenas o inglês. O objetivo é verificar se os mesmos padrões aparecem em diferentes populações e entender se os sinais identificados no Reddit também são observados entre outros grupos de usuários de medicamentos GLP-1.\u003c/p\u003e\u003cdiv class=\"exm_paragraph_end\"\u003e\u003c/div\u003e\n"])</script>
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