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70.ask-ia-faqs-item-expandable-container{color:var(--grey-1);font-family:var(--font-family-primary);font-size:1rem;font-style:normal;font-weight:400;letter-spacing:-.32px;line-height:24px;max-height:0;overflow:hidden;padding-bottom:0;transition:max-height .2s ease,padding-bottom .2s ease}.ask-ia-faqs-item-expandable-container a{color:var(--website-quaternary-color);text-decoration:none}.ask-ia-faqs-item.accordion-open .ask-ia-faqs-item-expandable-container{max-height:900px;padding-bottom:24px}.ask-ia-faqs-item-open-button{color:var(--grey-1);font-size:32px;font-style:normal;font-weight:500;letter-spacing:-.32px;line-height:27px}.ask-ia-faqs-item-open-button,.author{font-family:var(--font-family-primary)}.author{display:flex;margin:62px 0 42px}@media(min-width:769px)and (max-width:1058px){.author{flex-direction:column;gap:16px}}@media(max-width:768px){.author{flex-direction:column;gap:14px;margin:40px 0 32px;text-align:center}}.author-header{display:flex}@media(min-width:769px)and (max-width:1058px){.author-header{align-items:center}}@media(max-width:768px){.author-header{align-items:center;flex-direction:column;gap:14px}}.author-avatar{border-radius:50%;display:flex;height:130px;margin-right:20px;overflow:hidden;width:130px}.author-avatar .custom-image-placeholder{background-size:120px 25px}@media(min-width:769px)and (max-width:1058px){.author-avatar{height:96px;width:96px}.author-avatar .custom-image-placeholder{background-size:86px 18px}}@media(max-width:768px){.author-avatar{height:120px;margin-right:0;width:120px}.author-avatar .custom-image-placeholder{background-size:110px 23px}}.author-info{display:flex;flex-direction:column;gap:14px;margin-right:60px;width:225px}@media(min-width:769px)and 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70@media (max-height:550px),(max-width:400px){.react-datepicker__portal .react-datepicker__day,.react-datepicker__portal .react-datepicker__day-name,.react-datepicker__portal .react-datepicker__time-name{line-height:2rem;width:2rem}}.react-datepicker__portal .react-datepicker-time__header,.react-datepicker__portal .react-datepicker__current-month{font-size:1.44rem}.react-datepicker__children-container{height:auto;margin:.4rem;padding-left:.2rem;padding-right:.2rem;width:13.8rem}.react-datepicker__aria-live{border:0;clip-path:circle(0);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;white-space:nowrap;width:1px}.react-datepicker__calendar-icon{height:1em;vertical-align:-.125em;width:1em}.helper-links{background-color:#feffe2;border:1px solid var(--grey-5);display:flex;flex-direction:column;gap:10px;padding:5px 10px}.helper-links-item{align-items:flex-start;display:flex;gap:10px;line-height:1.5}.helper-links-item-label{font-weight:600;max-width:200px;min-width:25%}.helper-links-copy-button{cursor:pointer;min-width:25px}.helper-links-copy-button-success{transform:scaleX(.7)}.container{padding:24px 24px 20px}.container .header{align-items:flex-start;color:#2f2f2f;font-size:.875rem;justify-content:space-between;padding:24px 0 20px}.container .header,.container .title{display:flex;font-weight:400;line-height:1.5}.container .title{color:#000;flex-flow:column;font-size:1.5rem;margin-bottom:0;width:100%}.container .inputs{background-color:var(--white);border:1px solid var(--grey-7);margin-bottom:16px;padding:24px 16px 16px}.container .group{background-color:#f7f7f7;border:1px solid var(--grey-7);margin-bottom:32px;padding:16px}.container .group-legend{color:#2f2f2f;font-weight:700;padding-bottom:16px}.container .footer{display:flex;gap:16px;justify-content:end}.helper-links-toggle{margin-bottom:10px}.footer,.helper-links-toggle{display:flex;justify-content:flex-end}.footer{align-items:center;border:none;border-bottom-left-radius:3px;border-bottom-right-radius:3px;padding:20px 0 24px}.footer>:not(:last-child){margin-right:.25rem}.footer>:not(:first-child){margin-left:.25rem}.view-wrapper{display:contents}.campaign-label{background-color:rgba(255,204,0,.314);border-radius:2px;color:#9d7e00;padding:2px 6px;position:absolute;right:24px;top:24px}.react-datepicker-wrapper{border:none;color:#495057;font-size:1rem;font-weight:400;line-height:1.5;width:100%}.react-datepicker-wrapper:focus{background-color:var(--white);border-color:#ced4da;box-shadow:0 0 0 .2rem rgba(70,161,220,.25);color:#495057;outline:0}.react-datepicker-popper{z-index:2!important}.react-datepicker__navigation{top:7px}.datepicker{border:1px solid #ced4da;border-radius:3px;color:#495057;height:30px;padding:2px .75rem;width:100%}.datepicker:focus-visible{border:1px solid #ced4da}.category-content-block{margin-bottom:42px}@media(min-width:769px)and (max-width:1058px){.category-content-block{margin-bottom:35px}}@media(max-width:768px){.category-content-block{margin-bottom:35px}}.category-content-block .card-image{aspect-ratio:16/9;display:flex;position:relative}.category-content-block .card-image-supplier{align-items:center;border:1px solid var(--grey-3);justify-content:center;padding:8px}.category-content-block-header{align-items:center;border-bottom:2px solid;display:flex;justify-content:space-between;margin-bottom:24px;padding-bottom:10px}.category-content-block-header-link{align-self:end;color:var(--grey-1);display:flex;font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:500;gap:5px;letter-spacing:-.36px;line-height:normal;margin-left:20px;padding:0 0 2.3px;text-decoration:none;white-space:nowrap}@media(max-width:768px){.category-content-block-header-link{font-size:1.125rem;letter-spacing:-.18px}}.category-content-block-header-title{color:var(--grey-1);font-family:var(--font-family-primary);font-style:normal;font-weight:600}.category-content-block-header-title-md{font-size:1.625rem;letter-spacing:-.52px;line-height:31px}@media(max-width:768px){.category-content-block-header-title-md{line-height:30px}}.category-content-block-header-title-lg{font-size:1.875rem;letter-spacing:-.6px;line-height:36px}@media(max-width:768px){.category-content-block-header-title-lg{font-size:1.75rem;letter-spacing:-.28px;line-height:34px}}.category-content-block .card-text-date-author{display:inline-block}
70.category-content-block .card-text-date-author>*{display:inline}.category-content-block .card-text-date-author>:not(:last-child):after{color:var(--grey-3);content:" | ";font-size:14px;font-style:normal;font-weight:400;letter-spacing:-.14px;line-height:20px}.category-content-block .card-text-date-author,.category-content-block .card-text-info{color:var(--grey-5);font-family:var(--font-family-primary);font-size:.875rem;font-style:normal;font-weight:400;letter-spacing:-.14px;line-height:20px}.category-content-block-stories .card:first-child{grid-area:a}.category-content-block-stories .card:nth-child(2){grid-area:b}.category-content-block-stories .card:nth-child(3){grid-area:c}.category-content-block-stories .card:nth-child(4){grid-area:d}.category-content-block-stories-1{column-gap:24px;display:grid;grid-template-areas:"a a b b" "a a c c" "a a d d";grid-template-columns:repeat(4,1fr)}.category-content-block-stories-1 .card:first-child .card-text-headline{color:var(--grey-1);font-family:var(--font-family-primary);font-size:1.5rem;font-style:normal;font-weight:500;letter-spacing:-.48px;line-height:32px;margin-bottom:10px;margin-top:15px}.category-content-block-stories-1 .card:first-child .card-text-headline-lg{margin-top:17px}.category-content-block-stories-1 .card:first-child .card-text-headline-link{color:inherit}.category-content-block-stories-1 .card:first-child .card-text-headline .headline-with-icon{--headline-icon-top-spacing-default:3px;--headline-icon-top-spacing-mobile:3px}.category-content-block-stories-1 .card:nth-child(2) .card-text-headline .headline-with-icon,.category-content-block-stories-1 .card:nth-child(3) .card-text-headline .headline-with-icon{--headline-icon-top-spacing-default:0px;--headline-icon-top-spacing-mobile:-1px}.category-content-block-stories-1 .card:nth-child(n+2){display:flex;flex-direction:row-reverse}.category-content-block-stories-1 .card:nth-child(n+2) .card-image{flex:1}@media(max-width:768px){.category-content-block-stories-1 .card:nth-child(n+2) .card-image{align-items:unset}}.category-content-block-stories-1 .card:nth-child(n+2) .card-text{flex:2;margin-right:12px}.category-content-block-stories-1 .card:nth-child(n+2) .card-text-headline{color:#000;font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:500;line-height:24px;margin-bottom:10px}.category-content-block-stories-1 .card:nth-child(n+2) .card-text-headline-lg{margin-bottom:8px}.category-content-block-stories-1 .card:nth-child(n+2) .card-text-headline-link{color:inherit}.category-content-block-stories-1 .card:nth-child(3),.category-content-block-stories-1 .card:nth-child(4){border-top:1px solid var(--grey-3);margin-top:24px;padding-top:24px}@media(min-width:769px)and (max-width:1058px){.category-content-block-stories-1 .card:nth-child(n+2) .card-image{align-items:normal;flex:0;height:100px;width:100px}}.category-content-block-stories-2{column-gap:24px;display:grid;grid-template-areas:"a b c d";grid-template-columns:repeat(4,1fr)}.category-content-block-stories-2 .card{display:flex;flex-direction:column;gap:15px}.category-content-block-stories-2 .card-text-headline{color:#000;font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:500;letter-spacing:-.17px;line-height:24px;margin-bottom:9px}@media(max-width:768px){.category-content-block-stories-2 .card-text-headline{font-size:1.5rem;letter-spacing:-.48px;line-height:28px}.category-content-block-stories-2 .card-text-headline-lg{line-height:29px;margin-bottom:14px}}.category-content-block-stories-2 .card-text-headline-link{color:inherit}.category-content-block-stories-2 .card:first-child .headline-with-icon{--headline-icon-top-spacing-default:0px;--headline-icon-top-spacing-mobile:3px}.category-content-block-stories-2 .card:nth-child(2) .card-text-headline .headline-with-icon,.category-content-block-stories-2 .card:nth-child(3) .card-text-headline .headline-with-icon{--headline-icon-top-spacing-default:0px;--headline-icon-top-spacing-mobile:-1px}.category-content-block-stories-2 .card-image-supplier img{aspect-ratio:16/9;object-fit:contain;width:100%}
70.category-content-block-stories-2 .card-image-supplier .custom-image-placeholder{aspect-ratio:16/9}.category-content-block-stories-3{column-gap:24px;display:grid;grid-template-areas:"a b c";grid-template-columns:repeat(3,1fr)}.category-content-block-stories-3 .card{display:flex;flex-direction:column;gap:16px}@media(min-width:769px)and (max-width:1058px){.category-content-block-stories-3 .card{gap:15px}}.category-content-block-stories-3 .card-lg{gap:15px}@media(max-width:768px){.category-content-block-stories-3 .card-lg{gap:16px}}.category-content-block-stories-3 .card-text-headline{color:#000;font-family:var(--font-family-primary);font-style:normal;font-weight:500;letter-spacing:-.17px;line-height:24px;margin-bottom:9px}@media(max-width:768px){.category-content-block-stories-3 .card-text-headline{font-size:1.5rem;letter-spacing:-.48px;line-height:28px}}.category-content-block-stories-3 .card-text-headline-lg,.category-content-block-stories-3 .card-text-headline-md{font-size:1.25rem;line-height:26px}@media(max-width:768px){.category-content-block-stories-3 .card-text-headline-lg{line-height:29px}}.category-content-block-stories-3 .card-text-headline-link{color:inherit}.category-content-block-stories-3 .card:first-child .headline-with-icon{--headline-icon-top-spacing-default:0px;--headline-icon-top-spacing-mobile:3px}.category-content-block-stories-3 .card:nth-child(2) .card-text-headline .headline-with-icon,.category-content-block-stories-3 .card:nth-child(3) .card-text-headline .headline-with-icon{--headline-icon-top-spacing-default:0px;--headline-icon-top-spacing-mobile:-1px}.category-content-block-stories-3 .card:nth-child(4){display:none;grid-area:d}.category-content-block-stories .card-image-supplier img{aspect-ratio:16/9;object-fit:contain;width:100%}.category-content-block-stories .card-image-supplier .custom-image-placeholder{aspect-ratio:16/9}@media(min-width:769px)and (max-width:1058px){.category-content-block .custom-image-wrapper .custom-image-placeholder{background-size:88px 19px}}@media(max-width:768px){.category-content-block .custom-image-wrapper .custom-image-placeholder{background-size:64px 13px}.category-content-block-stories{display:flex;flex-direction:column}.category-content-block-stories .card-image-supplier{padding:4px}.category-content-block-stories .card{display:flex;flex-direction:column}.category-content-block-stories .card:first-child{gap:0}.category-content-block-stories .card:first-child .card-text-headline{color:var(--grey-1);font-family:var(--font-family-primary);font-style:normal;font-weight:500;letter-spacing:-.48px;margin-bottom:0;margin-top:15px}.category-content-block-stories .card:first-child .card-text-headline-md{font-size:1.125rem;letter-spacing:-.17px;line-height:24px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:first-child .card-text-headline-md{font-size:1.5rem;letter-spacing:-.48px;line-height:28px}}@media(max-width:768px){.category-content-block-stories .card:first-child .card-text-headline-lg{font-size:1.25rem;line-height:26px;margin-bottom:20px;margin-top:20px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:first-child .card-text-headline-lg{font-size:1.5rem;line-height:29px;margin-bottom:0;margin-top:15px}}@media(max-width:768px){.category-content-block-stories .card:first-child .card-text-headline-link{color:inherit}.category-content-block-stories .card:first-child .card-text-date-author,.category-content-block-stories .card:first-child .card-text-info{margin-top:10px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:first-child .card-text-date-author-lg,.category-content-block-stories .card:first-child .card-text-info-lg{margin-top:9px}}@media(max-width:768px){.category-content-block-stories .card:first-child .card-image-supplier img{aspect-ratio:16/9;object-fit:contain;width:100%}.category-content-block-stories .card:first-child .card-image-supplier .custom-image-placeholder{aspect-ratio:16/9}.category-content-block-stories .card:nth-child(n+2){border-top:1px solid var(--grey-3);display:flex;flex-direction:row;gap:16px;margin-top:18px;padding-top:24px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:nth-child(n+2):first-child{margin-top:20px;padding-top:20px}.category-content-block-stories .card:nth-child(n+2){margin-top:24px;padding-top:24px}}@media(max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-image{height:80px;width:80px}.category-content-block-stories .card:nth-child(n+2) .card-text{flex:0 1 calc(100% - 96px)}.category-content-block-stories .card:nth-child(n+2) .card-text-headline{color:#000;font-family:var(--font-family-primary);font-style:normal;font-weight:500;letter-spacing:-.17px;margin-bottom:0}.category-content-block-stories .card:nth-child(n+2) .card-text-headline-md{font-size:1.125rem;line-height:24px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-text-headline-md{font-size:1.0625rem;line-height:22px;margin-bottom:7px}}@media(max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-text-headline-lg{font-size:1.25rem;line-height:26px;margin-bottom:20px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-text-headline-lg{font-size:1.0625rem;line-height:22px;margin-bottom:0}}@media(max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-text-headline-link{color:inherit}.category-content-block-stories .card:nth-child(n+2) .card-text-date-author,.category-content-block-stories .card:nth-child(n+2) .card-text-info{margin-top:10px}}@media(max-width:768px)and (max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-text-date-author,.category-content-block-stories .card:nth-child(n+2) .card-text-info{margin-top:6px}}@media(max-width:768px){.category-content-block-stories .card:nth-child(n+2) .card-image-supplier .custom-image-placeholder{aspect-ratio:16/9}.category-content-block-stories .card:nth-child(n+2) .card-image-supplier img{aspect-ratio:1/1;object-fit:contain;width:100%}}.card-image{position:relative}.cross-publishing{background:#fff5d6;color:var(--grey-1);display:block;font-family:var(--font-family-primary);font-size:.875rem;font-weight:400;letter-spacing:-.28px;line-height:20px;margin-bottom:32px;margin-top:26px;padding:15px 19px}@media(min-width:769px)and (max-width:1058px){.cross-publishing{margin-bottom:28px}}@media(max-width:768px){.cross-publishing{margin-bottom:28px}}.cross-publishing a{color:var(--grey-1);text-decoration:none}.date-block{color:#70707b;font-family:var(--font-family-primary);font-size:.875rem;letter-spacing:-.084px;line-height:20px}@media(min-width:1059px)and (max-width:1439px){.editorial-promo{background-color:var(--grey-8);border-radius:4px;margin:auto 0 24px;padding:24px 18px}}@media(max-width:768px){.editorial-promo{background-color:var(--grey-8);border-radius:4px;margin:auto 0;padding:20px 14px}}.editorial-promo-header{align-items:baseline;display:flex;justify-content:space-between}@media(min-width:1059px)and (max-width:1439px){.editorial-promo-header{margin-bottom:24px}}@media(min-width:769px)and (max-width:1058px){.editorial-promo-header{align-items:flex-end;margin-bottom:15px}}@media(max-width:768px){.editorial-promo-header{margin:0 0 14px;padding-bottom:6px}}.editorial-promo-header-title{font-size:1rem;font-weight:700;line-height:1.4rem;text-transform:capitalize}@media(min-width:1059px)and (max-width:1439px){.editorial-promo-header-title{padding-bottom:6px}}@media(min-width:769px)and (max-width:1058px){.editorial-promo-header-title{padding-bottom:6px}}.editorial-promo-content{display:flex;flex-direction:column;justify-content:center}@media(min-width:769px)and (max-width:1058px){.editorial-promo-content{background-color:var(--grey-6);border-radius:4px;padding:14px 12px}}.editorial-promo-content-img{height:auto;max-width:100%;vertical-align:middle}@media(max-width:768px){.editorial-promo-content-img{align-self:center;max-width:300px}}.editor-info-content-email,.editor-info-content-label,.editor-info-content-phone,.editor-info-content-position{color:var(--grey-5);font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:400;line-height:24px}@media(max-width:768px){.editor-info-content-email,.editor-info-content-label,.editor-info-content-phone,.editor-info-content-position{font-size:1rem;font-style:normal;line-height:20px}}.editor-info-content-position{font-weight:500}.editor-info{display:flex;gap:24px;margin-bottom:20px;padding:4px 0 24px}@media(max-width:768px){.editor-info{gap:17px;margin-bottom:18px;padding:2px 0 20px}}.editor-info-separator{border-bottom:1px solid var(--grey-3)}.editor-info-image{flex-shrink:0;height:160px;width:160px}@media(max-width:768px){.editor-info-image{height:80px;width:80px}}.editor-info-image img{border-radius:4px}.editor-info-image .custom-image-placeholder{border-radius:4px;
70height:160px;width:160px}@media(max-width:768px){.editor-info-image .custom-image-placeholder{height:80px;width:80px}}.editor-info-content{display:flex;flex-direction:column;gap:6px}@media(max-width:768px){.editor-info-content{padding-top:0}}.editor-info-content-name{color:var(--grey-1);font-family:var(--font-family-primary);font-size:1.375rem;font-style:normal;font-weight:500;letter-spacing:-.22px;line-height:28px}@media(max-width:768px){.editor-info-content-name{font-size:1.25rem;letter-spacing:-.2px;line-height:24px}}.editor-info-content-email,.editor-info-content-phone{color:var(--grey-5);font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:400;line-height:24px}@media(max-width:768px){.editor-info-content-email,.editor-info-content-phone{font-size:1rem;font-style:normal;line-height:20px}}.editor-info-content-email{text-decoration-line:underline}@media(max-width:768px){.editors-choice{padding-top:16px}}.editors-choice-content-thumb{aspect-ratio:1/1;display:flex}@media(max-width:768px){.editors-choice-content-thumb{aspect-ratio:16/9}}.editors-choice-content-text-headline{color:var(--grey-1);font-family:var(--font-family-primary);font-size:1.3125rem;font-style:normal;font-weight:500;letter-spacing:-.21px;line-height:28px;margin:13px 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li{list-style-position:outside}@media(min-width:769px)and (max-width:1058px){.html-box-block-default ol,.html-box-block-default ul{margin-bottom:22px;margin-top:22px}}@media(max-width:768px){.html-box-block-default ol,.html-box-block-default ul{margin-bottom:22px;margin-top:22px}}.html-box-block-default ul{list-style-type:disc;margin-left:14px}.html-box-block-default ul li{margin-left:16px}.html-box-block-default ul ol,.html-box-block-default ul ul{margin-bottom:0;margin-left:28px;margin-top:0}.html-box-block-default ol{list-style-type:decimal;margin-left:14px}.html-box-block-default ol li{margin-left:21px}.html-box-block-default ol>ol{list-style-type:lower-latin}.html-box-block-default ol>ol>ol{list-style-type:disc}.html-box-block-default ol ol,.html-box-block-default ol ul{margin-bottom:0;margin-left:28px;margin-top:0}.html-box-block-default p{font-size:1.125rem;line-height:30px;margin-bottom:0;margin-top:25px!important;overflow:clip}.html-box-block-default 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70.html-box-block .Accordion_item .title_tab .title{font-weight:700}.html-css-box-block{font-family:inherit;font-size:inherit}.ia-answer-block{--miso-text-color:#18181b;--miso-text-color-gray:#666476;--miso-mark-background:none;--miso-border-color-light:#c1c8db;--miso-border-color-medium:#8f96a3;--miso-border-color-dark:#666476;--miso-box-shadow-hover:0 0 3px rgba(0,0,0,.1);--miso-transition:0.15s;--miso-collapsible-background:#f0f0f0;--miso-collapsible-body-max-height:12rem;--miso-collapsible-button-max-width:20rem;--miso-collapsible-border-radius:0.5rem;--miso-collapsible-content-spacing:0.75rem;--miso-loading-bar-color:#8f96a380;--miso-hybrid-search-combo-section-padding:2rem;--miso-hybrid-search-combo-section-spacing:4rem;--miso-hybrid-search-combo-content-max-width:none;--miso-hybrid-search-combo-content-padding:2rem;--miso-hybrid-search-combo-content-spacing:2rem;--miso-hybrid-search-combo-question-phrase-color:#a6a5bb;--miso-hybrid-search-combo-total-phrase-color:#a6a5bb;--miso-hybrid-search-combo-answer-box-background:#fff;--miso-hybrid-search-combo-answer-box-border-color:var(--miso-border-color-light);--miso-hybrid-search-combo-answer-box-phrase-color:var(--miso-text-color);--miso-hybrid-search-combo-answer-box-toggle-font-size:0.9rem;--miso-hybrid-search-combo-answer-box-toggle-padding:0.5rem;--miso-hybrid-search-combo-answer-box-toggle-max-width:20rem;--miso-hybrid-search-combo-answer-box-max-height:12rem;--miso-hybrid-search-combo-answer-box-toggle-color:var(--miso-text-color);--miso-hybrid-search-combo-answer-box-toggle-border-color:#a0a8be;--miso-hybrid-search-combo-answer-box-toggle-height:calc(var(--miso-hybrid-search-combo-answer-box-toggle-font-size)*2 + var(--miso-hybrid-search-combo-answer-box-toggle-padding)*2 + 2px);--miso-ask-combo-section-padding:2rem;--miso-ask-combo-section-spacing:4rem;--miso-ask-combo-content-max-width:none;--miso-ask-combo-content-padding:2rem;--miso-ask-combo-content-spacing:2rem;--miso-ask-combo-question-phrase-color:#a6a5bb;--miso-ask-combo-related-resources-background:#fffaf5;--miso-more-button-color:var(--miso-text-color);--miso-more-button-background:#fff;--miso-more-button-border-color:#a0a8be;--miso-more-button-max-width:20rem;--miso-select-width:7rem;--miso-select-border:1px solid #ccc;--miso-select-border-radius:9999px;--miso-select-background:#fff;--miso-select-border-color:#a0a8be;--miso-select-color:var(--miso-text-color);--miso-select-font-size:0.85rem;--miso-select-line-height-scale:1.5;--miso-select-line-height:calc(var(--miso-select-font-size)*var(--miso-select-line-height-scale));--miso-select-padding-x:1em;--miso-select-padding-y:0.5em;--miso-select-border-radius-computed:calc(var(--miso-select-padding-y) + var(--miso-select-font-size)*var(--miso-select-line-height)/2 + 1px);--miso-facet-color-unselected:var(--miso-text-color);--miso-facet-color-selected:#fff;--miso-facet-background-unselected:#fff;--miso-facet-background-selected:var(--miso-text-color);--miso-facet-border-color-unselected:#a0a8be;--miso-facet-border-color-selected:var(--miso-facet-color-unselected);--miso-feedback-color:#a0a8be;--miso-feedback-color-helpful:#1a4ce3;--miso-feedback-color-unhelpful:#ec5974;--miso-feedback-color-helpful-hover:rgba(26,76,227,.7);--miso-feedback-color-unhelpful-hover:rgba(236,89,116,.7);--miso-feedback-background-helpful-hover:rgba(44,141,237,.1);--miso-feedback-background-unhelpful-hover:rgba(236,89,116,.1);--miso-circled-citation-index-inverted-text-color:#fff;--miso-option-list-border-radius:9999px;--miso-option-list-item-padding:0.75rem;--miso-option-list-font-size:16px;--miso-option-list-line-height-scale:1.5;--miso-option-list-line-height:calc(var(--miso-option-list-font-size)*var(--miso-option-list-line-height-scale));--miso-option-list-item-gap:12px}@media(min-width:768px){.ia-answer-block{--miso-option-list-item-gap:15px}}.ia-answer-block{--miso-search-box-border-radius:9999px;--miso-search-box-font-size:1rem;--miso-search-box-line-height-scale:1.5;--miso-search-box-line-height:calc(var(--miso-search-box-font-size)*var(--miso-search-box-line-height-scale));--miso-search-box-icon-size:1.25rem;--miso-search-box-padding:0.75rem;--miso-search-box-padding-left:calc(var(--miso-search-box-padding) + var(--miso-search-box-line-height)*0.5 - 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0!important;padding:0;position:relative!important;right:0;top:0;width:640px}.pagination-container{display:flex;justify-content:center;margin-top:20px}
70.pagination-container .pagination{display:flex;gap:5px;list-style:none;padding:0}.pagination-container .page-number{margin:0}.pagination-container .page-number button{background-color:#007bff;border:none;border-radius:5px;color:#fff;cursor:pointer;display:inline-block;font-size:14px;padding:10px 15px;text-align:center;text-decoration:none;transition:background-color .3s ease}.pagination-container .page-number button:hover:not(:disabled){background-color:#0056b3}.pagination-container .page-number button:disabled{background-color:#ccc;cursor:not-allowed}.pagination-container .page-number button:focus{box-shadow:0 0 5px rgba(0,123,255,.5);outline:none}.jw-player .form{align-items:flex-start;display:flex;flex-direction:column}.jw-player .form>*{width:100%}.jw-player .form-row{display:flex;flex-direction:row;width:100%}.jw-player .selected-video{margin-bottom:20px}.jw-player .search-content{align-items:center;display:flex;flex-direction:column}.jw-player .search-result-item{align-items:center;background-color:var(--white);border:1px solid #ddd;border-radius:4px;box-shadow:0 2px 4px rgba(0,0,0,.1);display:flex;justify-content:space-between;margin-bottom:10px;padding:15px;transition:transform .3s ease;width:100%}.jw-player .search-result-item:hover{transform:translateY(-2px)}.jw-player .error-message{color:red}.jw-player .loading-message{color:#555}.jw-player-selected{display:flex;flex-direction:column;margin-bottom:20px}.lead-art{margin-bottom:16px}.megaphone-block{margin:40px 0;position:relative}.megaphone-block .custom-embed{height:200px}.megaphone-block.media-podcast.masked:before{background-color:hsla(0,0%,100%,.8);background-image:url(/pf/resources/images/masked-podcast.png?d=266&mxId=00000000);background-position:50%;background-size:cover;bottom:0;content:"";display:block;height:100%;left:0;position:absolute;right:0;top:0;width:100%;z-index:1}#pn-pv-counter{bottom:0;max-width:824px;position:fixed;width:100%;z-index:1}@media(min-width:1059px)and (max-width:1439px){#pn-pv-counter{left:calc(50% - 507px);width:589px}}@media(min-width:860px)and (max-width:1058px){#pn-pv-counter{left:calc(50% - 407px);width:459px}}@media(max-width:859px){#pn-pv-counter{left:0;max-width:859px;width:100%}}.most-read{border-bottom:none!important;margin-bottom:42px}@media(min-width:769px)and (max-width:1058px){.most-read{margin-bottom:35px}}@media(max-width:768px){.most-read{margin-bottom:35px}}.most-read-container{display:grid;gap:24px;grid-template-columns:repeat(3,1fr)}@media(min-width:769px)and (max-width:1058px){.most-read-container{grid-template-columns:repeat(2,1fr);row-gap:20px}}@media(max-width:768px){.most-read-container{grid-template-columns:repeat(1,1fr)}}.most-read-item{display:flex;flex:1;flex-direction:row;gap:20px}.most-read-item:not(:nth-child(-n+3)){border-top:1px solid var(--grey-3);margin-top:-5px;padding-top:20px}@media(max-width:768px){.most-read-item:not(:nth-child(-n+3)){margin-top:-8px}}@media(min-width:769px)and (max-width:1058px){.most-read-item:not(:nth-child(-n+2)){border-top:1px solid var(--grey-3);margin-top:0;padding-top:20px}}@media(max-width:768px){.most-read-item:not(:nth-child(-n+1)){border-top:1px solid var(--grey-3);margin-top:-5px;padding-top:20px}}.most-read-item-circle{align-items:center;background-color:var(--website-tertiary-color);border-radius:50%;color:var(--white);display:flex;font-family:var(--font-family-primary);font-size:24px;font-style:normal;font-weight:600;height:48px;justify-content:center;line-height:24px;width:48px}.most-read-item-circle:hover{background-color:var(--website-quaternary-color)}.most-read-item-info{width:calc(100% - 68px)}.most-read-item-info-headline{color:var(--grey-1);font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:500;letter-spacing:-.18px;line-height:24px}@media(max-width:768px){.most-read-item-info-headline{font-size:1.0625rem;letter-spacing:-.17px;line-height:22px}.most-read-item-info-headline .headline-with-icon{--headline-icon-top-spacing-mobile:-1px}}.most-read-item-info-headline-link{color:var(--grey-1)}.most-read-item-info-headline:hover{color:var(--website-quaternary-color)}.most-read-item-info-date{color:var(--grey-5);font-family:var(--font-family-primary);font-size:14px;font-style:normal;font-weight:400;letter-spacing:-.14px;line-height:20px;padding-top:8px}@media(min-width:769px)and (max-width:1058px){.most-read-item-info-date{padding-top:5px}}.not-found{font-family:var(--font-family-primary);margin-bottom:30px;margin-top:56px}
70@media(max-width:768px){.not-found{background-color:var(--white);padding:10px 0}}.not-found-title{color:var(--grey-1);font-family:var(--font-family-primary);font-size:2.25rem;font-weight:600;letter-spacing:-.56px;line-height:32px}@media(min-width:769px)and (max-width:1058px){.not-found-title{font-size:2rem}}.not-found-title{line-height:44px;margin-bottom:24px}.not-found-description{font-size:1.125rem;line-height:28px;margin-bottom:20px}.not-found-links{font-style:italic;margin-bottom:30px;margin-top:10px}.not-found-links-link{background-color:transparent;color:inherit;opacity:.7;text-decoration:none}.partner-insight{border-bottom:none;margin-bottom:42px}@media(min-width:769px)and (max-width:1058px){.partner-insight{margin-bottom:35px}}@media(max-width:768px){.partner-insight{margin-bottom:35px}}.partner-insight .homepage-block-template-header-title{display:flex;justify-content:space-between;width:100%}.partner-insight .homepage-block-template-header-title .partner-insight-more-link{align-self:end;color:var(--grey-1);display:flex;font-family:var(--font-family-primary);font-size:1.125rem;font-style:normal;font-weight:500;gap:5px;letter-spacing:-.36px;line-height:normal;margin-left:20px;padding:0 0 2.3px;text-decoration:none;white-space:nowrap}@media(max-width:768px){.partner-insight .homepage-block-template-header-title .partner-insight-more-link{display:none}}.partner-insight-stories-container{display:flex;gap:24px}@media(min-width:769px)and (max-width:1058px){.partner-insight-stories-container{display:grid;grid-template-columns:1fr 1fr}.partner-insight-stories-container .partner-insight-item:first-child{grid-row:span 3}.partner-insight-stories-container .partner-insight-item:first-child .partner-insight-item-details{gap:24px}.partner-insight-stories-container .partner-insight-item:first-child .partner-insight-item-headline{font-size:1.5rem;letter-spacing:-.48px;line-height:32px}.partner-insight-stories-container 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70.related-topics-container{color:var(--grey-1);display:flex;flex-wrap:wrap;gap:12px;margin-bottom:57px}@media(max-width:768px){.related-topics-container{margin-bottom:42px}}.related-topics-item{background-color:var(--link-background-color);border-radius:100px;color:var(--grey-1);font-size:1rem;font-weight:500;line-height:normal;padding:8px 14px 9px;text-decoration:none}.related-topics-item:hover{background-color:var(--link-hover-background-color);color:var(--grey-1);cursor:pointer}.related-topics-item-mode-light:hover{color:var(--global-white)}.right-hand-ads-container{--ad-track-height:800px;--ad-track-gap:24px;display:flex;flex:1;flex-direction:column;gap:var(--ad-track-gap);min-height:0}.right-hand-ads-sticky-track{flex:0 0 var(--ad-track-height);height:var(--ad-track-height)}.right-hand-ads-sticky-track[data-empty]{display:none}.right-hand-ads-sticky-track--final{flex-grow:1;height:auto}.right-hand-ads-ad-slot{display:block;position:sticky;top:75px}.right-hand-ads-sentinel{flex:0 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94<script data-help="gam-consent"> 95 (function() { 96 const getCookie = (name) => { 97 try { 98 const value = '; ' + document.cookie; 99 const parts = value.split('; ' + name + '='); 100 if (parts.length === 2) { 101 return parts.pop().split(';').shift(); 102 } 103 return null; 104 } catch (error) { 105 console.warn('[GAM Consent] Error in getCookie:', error); 106 return null; 107 } 108 }; 109 110 const isTcfActive = () => { 111 try { 112 return typeof window.__tcfapi === 'function'; 113 } catch (error) { 114 return false; 115 } 116 }; 117 118 const hasTargetingConsent = () => { 119 try { 120 const groups = (window.OptanonActiveGroups || window.OnetrustActiveGroups || '') + ''; 121 return groups.indexOf(',C0004,') > -1; 122 } catch (error) { 123 console.warn('[GAM Consent] Error checking targeting consent:', error); 124 return false; 125 } 126 }; 127 128 const hasUserActuallyInteracted = () => { 129 try { 130 const cookieValue = getCookie('OptanonConsent'); 131 132 if (!cookieValue) { 133 return false; 134 } 135 136 const decodedValue = decodeURIComponent(cookieValue); 137 138 if (decodedValue === 'isGpcEnabled' || decodedValue === 'isIABGlobal=false&datestamp=') { 139 return false; 140 } 141 142 if (decodedValue.includes('groups=')) { 143 const groupsMatch = decodedValue.match(/groups=([^&]+)/); 144 if (groupsMatch) { 145 const groups = decodeURIComponent(groupsMatch[1]); 146 147 if (groups.includes('C0004:') || groups.includes('C0004%3A')) { 148 return true; 149 } 150 } 151 } 152 153 const banner = document.getElementById('onetrust-banner-sdk'); 154 const bannerVisible = banner && banner.style.display !== 'none' && !banner.classList.contains('ot-hide'); 155 156 if (bannerVisible) { 157 return false; 158 } 159 160 if (decodedValue.includes('datestamp=') && decodedValue.includes('version=')) { 161 return true; 162 } 163 164 return false; 165 } catch (error) { 166 console.warn('[GAM Consent] Error checking user interaction:', error); 167 return false; 168 } 169 }; 170 171 const getConsentFromCookie = () => { 172 try { 173 const cookieValue = getCookie('OptanonConsent'); 174 175 if (!cookieValue) { 176 return null; 177 } 178 179 const decodedValue = decodeURIComponent(cookieValue); 180 181 const groupsMatch = decodedValue.match(/groups=([^&]+)/); 182 if (!groupsMatch) { 183 return null; 184 } 185 186 const groupsEncoded = groupsMatch[1]; 187 const groups = decodeURIComponent(groupsEncoded); 188 189 const patterns = [ 190 new RegExp('C0004:(\\d)'), 191 new RegExp('C0004%3A(\\d)'), 192 new RegExp('C0004%253A(\\d)'), 193 ]; 194 195 for (let i = 0; i < patterns.length; i++) { 196 const pattern = patterns[i]; 197 const match = groups.match(pattern); 198 if (match) { 199 return match[1] === '1'; 200 } 201 } 202 203 return null; 204 } catch (error) { 205 console.warn('[GAM Consent] Error parsing OptanonConsent cookie:', error); 206 return null; 207 } 208 }; 209 210 const getRegion = () => { 211 try { 212 if (window.OneTrust && typeof window.OneTrust.getGeolocationData === 'function') { 213 const geoData = window.OneTrust.getGeolocationData(); 214 if (geoData && geoData.country) { 215 return geoData.country; 216 } 217 } 218 219 return null; 220 } catch (error) { 221 console.warn('[GAM Consent] Error determining region:', error); 222 return null; 223 } 224 }; 225 226 const isUSRegion = () => { 227 const region = getRegion(); 228 return region === 'US' || region === 'USA'; 229 }; 230 231 const setPrivacySettings = (consented, shouldRefresh = false, reason = 'unknown') => { 232 window.googletag = window.googletag || { cmd: [] }; 233 window.googletag.cmd.push(() => { 234 try { 235 const pubads = googletag.pubads(); 236 pubads.setPrivacySettings({ 237 nonPersonalizedAds: !consented, 238 restrictDataProcessing: !consented, 239 }); 240 241 if (shouldRefresh && (reason === 'user_consent_change' && consented)) { 242 pubads.refresh(); 243 } 244 } catch (error) { 245 console.warn('[GAM Consent] Error applying privacy settings:', error); 246 } 247 }); 248 }; 249 250 const processConsent = () => { 251 if (isTcfActive()) { 252 window.gamConsentReady = true; 253 window.dispatchEvent(new CustomEvent('gamConsentApplied')); 254 return; 255 } 256
257 const cookieConsent = getConsentFromCookie(); 258 259 if (cookieConsent !== null) { 260 setPrivacySettings(cookieConsent, false, 'cookie_load'); 261 window.gamConsentReady = true; 262 window.dispatchEvent(new CustomEvent('gamConsentApplied')); 263 return; 264 } 265 266 const userInteracted = hasUserActuallyInteracted(); 267 268 if (!userInteracted) { 269 const isUS = isUSRegion(); 270 271 if (isUS) { 272 setPrivacySettings(true, false, 'initial_load_no_interaction_us'); 273 } else { 274 setPrivacySettings(false, false, 'initial_load_no_interaction_row'); 275 } 276 277 window.gamConsentReady = true; 278 window.dispatchEvent(new CustomEvent('gamConsentApplied')); 279 return; 280 } 281 282 const currentConsent = hasTargetingConsent(); 283 const groups = (window.OptanonActiveGroups || window.OnetrustActiveGroups || '') + ''; 284 285 if (groups) { 286 setPrivacySettings(currentConsent, false, 'groups_load'); 287 window.gamConsentReady = true; 288 window.dispatchEvent(new CustomEvent('gamConsentApplied')); 289 } else { 290 setPrivacySettings(false, false, 'fallback_no_groups'); 291 window.gamConsentReady = true; 292 window.dispatchEvent(new CustomEvent('gamConsentApplied')); 293 } 294 }; 295 296 const handleConsentChange = () => { 297 if (isTcfActive()) { 298 return; 299 } 300 301 const consented = hasTargetingConsent(); 302 setPrivacySettings(consented, true, 'user_consent_change'); 303 }; 304 305 const wireConsentHandlers = () => { 306 if (window.OneTrust && typeof window.OneTrust.OnConsentChanged === 'function') { 307 window.OneTrust.OnConsentChanged(handleConsentChange); 308 } 309 }; 310 311 const prevOptanonWrapper = window.OptanonWrapper; 312 window.OptanonWrapper = () => { 313 if (window.OptanonWrapper?.executed) return; 314 315 window.OptanonWrapper.executed = true; 316 317 if (typeof prevOptanonWrapper === 'function') { 318 try { 319 prevOptanonWrapper(); 320 } catch (error) { 321 console.warn('[GAM Consent] Error calling previous OptanonWrapper:', error); 322 } 323 } 324 325 processConsent(); 326 wireConsentHandlers(); 327 }; 328 329 if (window.OneTrust && !window.OptanonWrapper?.executed) { 330 window.OptanonWrapper(); 331 } 332 })(); 333 </script>
333<script data-help="gpt" defer=""> 334 335 const setCookie = ({ key, value, expireInDays = 1 }) => { 336 if (key && value) { 337 const date = new Date(); 338 date.setTime(date.getTime() + expireInDays * 24 * 60 * 60 * 1000); 339 document.cookie = `${key}=${value}; expires=${date.toUTCString()}; path=/`; 340 } 341 } 342 343 if (window?.navigator?.userAgent?.toLowerCase()?.indexOf('cxensebot') === -1) { 344 345 const cX = window.cX || { callQueue: [], options: {campaignReporting: true } }; 346 window.cX = cX; 347 348 let gamInitialized = false; 349 350 const initializeGAMWithSegments = (segments = []) => { 351 if (gamInitialized) return; 352 gamInitialized = true; 353 354 googletag.cmd.push(() => { 355 const cXids = []; 356 const onlyContextualIds = []; 357 358 if (segments.length > 0) { 359 window.cX.Array.forEach(segments, (cxTypedSegment) => { 360 if (cxTypedSegment.type === "contextual") { 361 onlyContextualIds.push(cxTypedSegment.id); 362 } else { 363 cXids.push(cxTypedSegment.id); 364 } 365 }); 366 367 googletag.setConfig({ targeting: { CxSegments: cXids } }); 368 googletag.setConfig({ targeting: { CxContext: onlyContextualIds } }); 369 } 370 371 (async () => { 372 let isBlocked = false; 373 374 const __adblocker = getCookie('__adblocker'); 375 376 if (__adblocker !== undefined) { 377 isBlocked = __adblocker === 'true'; 378 } else if (typeof tp !== 'undefined' && tp.util && typeof tp.util.getAdblockStatus === 'function') { 379 const adblockStatus = tp.util.getAdblockStatus(); 380 isBlocked = adblockStatus !== 0; 381 } 382 383 cX.callQueue.push(['setCustomParameters', { 'adblocker': isBlocked ? 'true' : 'false' }]); 384 })(); 385 386 387 const isMobile = window.innerWidth < 768; 388 389 const enableGAMServices = () => { 390 googletag.cmd.push(() => { 391 googletag.setConfig({ collapseDiv: 'ON_NO_FILL', targeting: { 'ni_id': 'news' } }); 392 googletag.setConfig({ targeting: { loggedin: localStorage.getItem('loggedInStatus') === '1' ? 'True' : 'False' } }); 393 googletag.setConfig({ targeting: { 'ni_cat': "news" } }); 394 if (isMobile) { 395 396 (slot => slot?.setConfig({ targeting: { adslot: 'rectangle1' } }))( 397 googletag 398 .defineSlot( 399 '/269346476/ni/ni_mobile/ni_mobile_section_landing', 400 [[320,100],[320,50]], 401 'rectangle1' 402 ) 403 ?.addService(googletag.pubads()) 404 ); 405 406 } else { 407 408 window.prestitialCookie = getCookie('__prestitial'); 409 if (window.prestitialCookie !== '1') { 410 411 setTimeout(() => { 412 setCookie({ key: '__prestitial', value: '1', expireInDays: 1 }); 413 }, 5000); 414 415 (slot => slot?.setConfig({ targeting: { adslot: 'interstitial' } }))( 416 googletag 417 .defineSlot( 418 '/269346476/ni/ni_desktop/ni_desktop_section_landing', 419 [[640,480]], 420 'interstitial' 421 ) 422 ?.addService(googletag.pubads()) 423 ); 424 425 } 426 427 428 (slot => slot?.setConfig({ targeting: { adslot: 'wallpaper' } }))( 429 googletag 430 .defineOutOfPageSlot( 431 '/269346476/ni/ni_desktop/ni_desktop_section_landing', 432 433 'wallpaper' 434 ) 435 ?.addService(googletag.pubads()) 436 ); 437 438 439 (slot => slot?.setConfig({ targeting: { adslot: 'leaderboard' } }))( 440 googletag 441 .defineSlot( 442 '/269346476/ni/ni_desktop/ni_desktop_section_landing', 443 [[970,90],[970,250]], 444 'leaderboard' 445 ) 446 ?.addService(googletag.pubads()) 447 ); 448 449 } 450 451 if (undefined) { 452 googletag.setConfig({ 453 lazyLoad: { 454 fetchMarginPercent: 5, 455 renderMarginPercent: 5, 456 mobileScaling: 0, 457 }, 458 }); 459 } 460 googletag.enableServices(); 461 window.gamReady = true; 462 window.dispatchEvent(new CustomEvent('gamReady')); 463 }); 464 }; 465 466 467 if (window.gamConsentReady) { 468 enableGAMServices(); 469 } else {
470 let consentTimeout; 471 const enableWithConsent = () => { 472 if (consentTimeout) clearTimeout(consentTimeout); 473 enableGAMServices(); 474 }; 475 476 window.addEventListener('gamConsentApplied', enableWithConsent, { once: true }); 477 478 consentTimeout = setTimeout(() => { 479 window.removeEventListener('gamConsentApplied', enableWithConsent); 480 enableGAMServices(); 481 }, 10000); 482 } 483 484 485 }); 486 }; 487 488 const pianoTimeout = setTimeout(() => { 489 initializeGAMWithSegments(); 490 }, 2000); 491 492 const googleAdSetup = segments => { 493 clearTimeout(pianoTimeout); 494 initializeGAMWithSegments(segments); 495 }; 496 497 let cxCheckAttempts = 0; 498 const maxCxCheckAttempts = 20; 499 500 const waitForCX = () => { 501 cxCheckAttempts++; 502 503 if (window.cX && window.cX.getSegments && typeof window.cX.getSegments === 'function') { 504 window.cX.getSegments('8cb9cd7941f33790132d47625f0228166bf64163', googleAdSetup); 505 } else if (cxCheckAttempts < maxCxCheckAttempts) { 506 setTimeout(waitForCX, 100); 507 } else { 508 initializeGAMWithSegments(); 509 } 510 }; 511 512 waitForCX(); 513 514 } 515 </script>
515<script>window.digitalData = {"journey_data":{},"user_data":{"company":null,"company_type":null,"days_left_on_subscription":null,"end_date":null,"industry":null,"job_title":null,"registered_user_id":null,"responsibility":null,"start_date":null,"subscription_level":null,"subscription_level_name":null},"page_data":{"platform":"Arc XP","ad_blocker_present":false,"page_id":"/News","page_type":"Subject page","enableMegaphoneBlock":null},"search_data":{},"article_data":{},"miso_data":{"sticky_widget_view":null,"explore_question_view":null,"answer_page_view":null,"search_query":null,"question_asked":null,"search_query_source":null,"insufficient_information":null}}; 516 517 if (window.digitalData && window.digitalData.user_data) { 518 window.digitalData.user_data.logged_in_status = localStorage.getItem('loggedInStatus') === '1' ? 'Logged in' : 'Logged out'; 519 } 520 521 const ADBLOCK_REQUEST_URL = 'https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js'; 522 const ADBLOCK_REQUEST_CONFIG = { 523 method: 'HEAD', 524 mode: 'no-cors', 525 }; 526 (async () => { 527 try { 528 const response = await fetch(ADBLOCK_REQUEST_URL, ADBLOCK_REQUEST_CONFIG); 529 if (window.digitalData && window.digitalData.page_data) { 530 window.digitalData.page_data.ad_blocker_present = response.redirected; 531 } 532 } catch { 533 if (window.digitalData && window.digitalData.page_data) { 534 window.digitalData.page_data.ad_blocker_present = true; 535 } 536 } 537 })(); 538 539 const CONFIRM = "confirm=1"; 540 541 (function() { 542 document.addEventListener("DOMContentLoaded", (event) => { 543 const search = window?.location?.search ?? ''; 544 const hasConfirmation = search.includes(CONFIRM); 545 546 const cookie = document.cookie 547 .split('; ') 548 .find(item => item.startsWith('dnm_l')) 549 ?.split('=')[1]; 550 551 const hasCampaignCookie = cookie?.includes('undefined'); 552 const hasStoryCookie = cookie?.includes('/News'); 553 554 const urlParams = new URLSearchParams(window.location.search); 555 const defaultAccess = urlParams.get('default_access'); 556 const isDefaultAccess = defaultAccess === '/News-nutraingredients-v2'; 557 558 if (window.digitalData) { 559 if (!hasConfirmation || !(hasCampaignCookie || hasStoryCookie || isDefaultAccess)) { 560 delete window.digitalData.lead_data; 561 } else { 562 const nonParsed = window.digitalData.lead_data; 563 window.digitalData.lead_data = JSON.parse(nonParsed); 564 } 565 } 566 }) 567 })(); 568</script>
568<script data-ot-ignore="true" src="https://assets.adobedtm.com/eb2e22881c4a/eca1b21caf50/launch-d12cb4e80409.min.js"></script>
568<script data-ot-ignore="true" data-help="piano"> 569 (function(src) { 570 const startTime = performance.now(); 571 console.log('[Piano Debug] Initial script position:', document.scripts.length, 'Time:', new Date().toISOString()); 572 573 var a = document.createElement('script'); 574 a.type = 'text/javascript'; 575 a.async = true; 576 a.src = src; 577 var b = document.getElementsByTagName('script')[0]; 578 b.parentNode.insertBefore(a, b); 579 580 // Create mutation observer to track Piano script loading 581 const observer = new MutationObserver((mutations) => { 582 mutations.forEach((mutation) => { 583 mutation.addedNodes.forEach((node) => { 584 if (node.tagName === 'SCRIPT' && node.src) { 585 const currentTime = performance.now(); 586 const timeElapsed = (currentTime - startTime).toFixed(2); 587 588 if (node.src.includes('tinypass.min.js')) { 589 console.log('[Piano Debug] Tinypass script loaded at position', document.scripts.length, 'after', timeElapsed + 'ms'); 590 } 591 } 592 }); 593 }); 594 }); 595 596 observer.observe(document.head, { 597 childList: true, 598 subtree: true 599 }); 600 })("//experience.tinypass.com/xbuilder/experience/load?aid=ir89Y7o5pu"); 601 </script>
601<script defer=""> 602 tp = window["tp"] || []; 603 604 tp.push(['setContentSection', 'section landing']); 605 tp.push(['setTags', ["section-landing"]]); 606 tp.push(['setContentIsNative', false]); 607 </script>
607<script data-help="gtm-piano-analytics"> 608 (function(w,d,s,l,i){ 609 w[l]=w[l]||[]; 610 w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'}); 611 612 var f=d.getElementsByTagName(s)[0], 613 j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:''; 614 j.async=true; 615 j.src='https://wrss.nutraingredients.com/o1pft3fdew1z6wz.js?awl='+i.replace(/^GTM-/,'')+dl; 616 617 f.parentNode.insertBefore(j,f); 618 })(window,document,'script','dataLayer','GTM-KV8SCQPL'); 619 </script>
619<script data-ot-ignore="true" data-integration="gtm"> 620 (() => { 621 622 const sanitizeGtmValue = value => { 623 if (value === null || value === undefined || value === '') { 624 return undefined; 625 } 626 if (typeof value === 'number') { 627 return Number(value.toFixed(2)); 628 } 629 if (typeof value === 'string') { 630 return value.replace(/[&"'"']/g, '').trim() || undefined; 631 } 632 return value; 633}; 634 635 const isDigitalDataAvailableForPA = isGtmPaEnabled => { 636 // eslint-disable-next-line no-underscore-dangle 637 const enabled = isGtmPaEnabled ?? window.__isGtmPaEnabled; 638 return enabled && window?.dataLayer; 639}; 640 641 const extractUtmParameters = () => { 642 if (typeof document === 'undefined' || !document.location || !document.location.search) { 643 return {}; 644 } 645 const urlParams = new URLSearchParams(document.location.search); 646 return { 647 utm_source: sanitizeGtmValue(urlParams.get('utm_source')), 648 utm_medium: sanitizeGtmValue(urlParams.get('utm_medium')), 649 utm_campaign: sanitizeGtmValue(urlParams.get('utm_campaign')), 650 utm_term: sanitizeGtmValue(urlParams.get('utm_term')), 651 utm_content: sanitizeGtmValue(urlParams.get('utm_content')) 652 }; 653}; 654 655 const pushPianoRegisterEvent = () => { 656 if (!dataLayer_isDigitalDataAvailableForPA()) return; 657 window.dataLayer.push({ 658 event: sanitizeGtmValue('register') 659 }); 660}; 661 662 const pushPianoConnectionEvent = interactionTarget => { 663 if (!dataLayer_isDigitalDataAvailableForPA()) return; 664 window.dataLayer.push({ 665 event: sanitizeGtmValue('connection_interactions'), 666 interaction_target: sanitizeGtmValue(interactionTarget) 667 }); 668}; 669 670 const pushPianoPasswordResetEvent = () => { 671 if (!dataLayer_isDigitalDataAvailableForPA()) return; 672 window.dataLayer.push({ 673 event: sanitizeGtmValue('password_reset_interaction') 674 }); 675}; 676 677 const getRegwallData = () => { 678 try { 679 const meterValue = window?.meterValue; 680 const hasMeter = meterValue && typeof meterValue === 'object'; 681 682 // eslint-disable-next-line no-underscore-dangle 683 const experienceResult = window?.tp?.experience?._getLastExecutionResult?.(); 684 const showOfferEvent = experienceResult?.result?.events?.find(e => e.eventType === 'showOffer'); 685 const viewsLeft = hasMeter ? meterValue?.viewsLeft : 0; 686 const views = hasMeter ? meterValue?.views : undefined; 687 const maxViews = hasMeter ? meterValue?.maxViews : undefined; 688 const meterName = hasMeter ? meterValue?.meterName : undefined; 689 const templateIdFromExperience = showOfferEvent?.eventParams?.templateId; 690 const templateNameFromExperience = showOfferEvent?.eventModuleParams?.moduleName; 691 const dataLayerItem = window.dataLayer?.find(item => item.article_paywall_id && item.article_paywall_template); 692 const templateId = templateIdFromExperience || dataLayerItem?.article_paywall_id || ''; 693 const templateName = templateNameFromExperience || dataLayerItem?.article_paywall_template || ''; 694 const hit = viewsLeft === 0 || dataLayerItem?.article_paywall_hit || false; 695 return { 696 templateName, 697 templateId, 698 hit, 699 viewsLeft: viewsLeft !== null && viewsLeft !== undefined ? String(viewsLeft) : '', 700 views: views !== null && views !== undefined ? String(views) : '', 701 maxViews: maxViews !== null && maxViews !== undefined ? String(maxViews) : '', 702 meterName: meterName || '' 703 }; 704 } catch (error) { 705 console.warn('[GTM Regwall] Error getting regwall data:', error); 706 return { 707 templateName: '', 708 templateId: '', 709 hit: false, 710 viewsLeft: '', 711 views: '', 712 maxViews: '', 713 meterName: '' 714 }; 715 } 716}; 717 718 const pushRegwallInteraction = interactionTarget => { 719 if (!window.dataLayer) { 720 console.warn('[GTM Regwall] dataLayer not initialized'); 721 return; 722 } 723 const regwallData = getRegwallData(); 724 window.dataLayer.push({ 725 event: sanitizeGtmValue('regwall_interactions'), 726 article_regwall_template: sanitizeGtmValue(regwallData.templateName), 727 article_regwall_id: sanitizeGtmValue(regwallData.templateId), 728 article_regwall_hit: regwallData.hit, 729 article_number_remaining: sanitizeGtmValue(regwallData.viewsLeft),
730 interaction_target: sanitizeGtmValue(interactionTarget), 731 interaction_area: sanitizeGtmValue('regwall') 732 }); 733}; 734 735 const pushPaywallInteraction = interactionTarget => { 736 if (!dataLayer_isDigitalDataAvailableForPA()) { 737 return; 738 } 739 if (!window.dataLayer) { 740 return; 741 } 742 const meterValue = window?.meterValue; 743 const hasMeter = meterValue && typeof meterValue === 'object'; 744 const viewsLeft = hasMeter ? meterValue?.viewsLeft : 0; 745 const pageViewEvent = window.dataLayer.findLast(item => item?.event === 'page_view'); 746 const templateId = pageViewEvent?.article_paywall_id || ''; 747 const templateName = pageViewEvent?.article_paywall_template || ''; 748 const paywallHit = pageViewEvent?.article_paywall_hit ?? true; 749 const eventData = { 750 event: sanitizeGtmValue('paywall_interactions'), 751 article_paywall_template: sanitizeGtmValue(templateName), 752 article_paywall_id: sanitizeGtmValue(templateId), 753 article_paywall_hit: paywallHit, 754 article_number_remaining: sanitizeGtmValue(viewsLeft !== null && viewsLeft !== undefined ? String(viewsLeft) : ''), 755 interaction_target: sanitizeGtmValue(interactionTarget), 756 interaction_area: sanitizeGtmValue('paywall') 757 }; 758 window.dataLayer.push(eventData); 759}; 760 761 const pushSubscribeEvent = ({ 762 subscriptionLevelId, 763 subscriptionLevelName, 764 interactionArea 765}) => { 766 if (!dataLayer_isDigitalDataAvailableForPA()) return; 767 window.dataLayer.push({ 768 event: sanitizeGtmValue('subscribe'), 769 subscription_level_id: sanitizeGtmValue(subscriptionLevelId), 770 subscription_level_name: sanitizeGtmValue(subscriptionLevelName), 771 interaction_area: sanitizeGtmValue(interactionArea) 772 }); 773}; 774 775 const pushRegistrationFormError = interactionDetails => { 776 if (!window.dataLayer) { 777 window.dataLayer = []; 778 } 779 if (!window.registrationErrorsSent) { 780 window.registrationErrorsSent = new Set(); 781 } 782 if (window.registrationErrorsSent.has(interactionDetails)) { 783 return; 784 } 785 window.registrationErrorsSent.add(interactionDetails); 786 if (window.registrationErrorsTimer) { 787 clearTimeout(window.registrationErrorsTimer); 788 } 789 const sendAccumulatedErrors = () => { 790 if (!window.registrationErrorsSent || window.registrationErrorsSent.size === 0) { 791 return; 792 } 793 const errorsArray = Array.from(window.registrationErrorsSent); 794 const combinedErrors = errorsArray.join(' | '); 795 const errorData = { 796 event: sanitizeGtmValue('interaction_error'), 797 interaction_area: sanitizeGtmValue('form'), 798 interaction_target: sanitizeGtmValue('account creation'), 799 interaction_details: sanitizeGtmValue(combinedErrors), 800 interaction_value: sanitizeGtmValue('error') 801 }; 802 window.dataLayer.push(errorData); 803 window.registrationErrorsSent.clear(); 804 window.registrationErrorsTimer = null; 805 }; 806 window.registrationErrorsTimer = setTimeout(sendAccumulatedErrors, 2000); 807}; 808 809 const pushRestoreFormError = () => { 810 if (!window.dataLayer) { 811 window.dataLayer = []; 812 } 813 window.dataLayer.push({ 814 event: sanitizeGtmValue('interaction_error'), 815 interaction_area: sanitizeGtmValue('form'), 816 interaction_target: sanitizeGtmValue('restore password'), 817 interaction_details: sanitizeGtmValue('general error'), 818 interaction_value: sanitizeGtmValue('error') 819 }); 820}; 821 822 const pushSignInEvent = eventName => { 823 if (!dataLayer_isDigitalDataAvailableForPA()) return; 824 const eventObj = { 825 eventName: sanitizeGtmValue(eventName), 826 params: { 827 eventName: sanitizeGtmValue(eventName) 828 } 829 }; 830 if (eventName === 'Sign-In-Success') { 831 try { 832 localStorage.setItem('gtm_sign_in_event', JSON.stringify(eventObj)); 833 } catch (error) { 834 console.warn('[Data Layer] Error saving sign-in event to localStorage:', error); 835 } 836 return; 837 } 838 window.dataLayer.push(eventObj); 839}; 840 841 const pianoEventListener = allowedOrigins => { 842 const mmrRibbonSignInPattern = /^MMR-\d+\/\d+ - Ribbon Sign in - Click$/; 843 const mmrRegisterNowClickPattern = /^MMR-\d+\/\d+ - Register Now - Click( Desktop)?$/; 844 window.addEventListener('message', event => { 845 if (!allowedOrigins.includes(event.origin)) return; 846 const eventData = JSON.parse(event.data); 847 if (eventData?.event === 'pianoIdEvent') { 848 if (eventData?.params?.event === 'registrationSuccess') { 849 const hasRegisterEvent = window.dataLayer?.some(item => item?.event === 'register'); 850 if (!hasRegisterEvent) { 851 pushPianoRegisterEvent(); 852 } 853 return; 854 } 855 const eventCategory = eventData?.params?.params?.eventCategory; 856 if (eventCategory === 'loginDisplayed') { 857 pushLoginFormPageView(); 858 return; 859 } 860 if (eventCategory === 'registrationDisplayed') { 861 pushRegistrationFormPageView(); 862 return; 863 } 864 } 865 if (eventData?.event === 'emitGAEvent') { 866 const eventCategory = eventData?.params?.eventCategory; 867 if (eventCategory === 'loginDisplayed') { 868 pushLoginFormPageView(); 869 return; 870 } 871 if (eventCategory === 'registrationDisplayed') { 872 pushRegistrationFormPageView(); 873 return; 874 } 875 } 876 const eventName = eventData?.eventName || eventData?.params?.eventName || eventData?.params?.params?.eventName; 877 if (!eventName) return; 878 if (mmrRibbonSignInPattern.test(eventName)) { 879 pushRegwallInteraction('sign in'); 880 return; 881 } 882 if (mmrRegisterNowClickPattern.test(eventName)) { 883 pushRegwallInteraction('register now'); 884 return; 885 } 886 switch (eventName) { 887 case 'HRW - Register Now CTA - Click': 888 case 'Register Form - Submit - Click': 889 if (window.registrationErrorsTimer) { 890 clearTimeout(window.registrationErrorsTimer); 891 window.registrationErrorsTimer = null; 892 } 893 if (window.registrationErrorsSent) { 894 window.registrationErrorsSent.clear(); 895 } 896 break; 897 case 'ARW - Register Now CTA - Click': 898 pushRegwallInteraction('register now'); 899 break; 900 case 'ARW - Sign in - Click': 901 pushRegwallInteraction('sign in'); 902 break; 903 case 'ARW - Registration benefits - Click': 904 case 'MMR-Registration-Benefits': 905 pushRegwallInteraction('registration benefits'); 906 break; 907 case 'Sign_In_Clicked': 908 case 'PIDLP - Sign in - Click': 909 break; 910 case 'RR - Register Now CTA - Click': 911 pushRegwallInteraction('register now'); 912 break; 913 case 'RR - Sign in - Click': 914 pushRegwallInteraction('sign in'); 915 break; 916 case 'forgotten_password_submit_button_clicked': 917 pushPianoConnectionEvent('password reset'); 918 pushPianoPasswordResetEvent(); 919 break; 920 case 'forgotten_password_link_clicked': 921 pushPianoConnectionEvent('forgotten password'); 922 break; 923 case 'Registration-Form-Error': 924 pushRegistrationFormError('general error'); 925 break; 926 case 'Registration-Form-Email-Error': 927 pushRegistrationFormError('email'); 928 break; 929 case 'Registration-Form-Password-Error': 930 pushRegistrationFormError('password'); 931 break; 932 case 'Registration-Form-Company-Error': 933 pushRegistrationFormError('company'); 934 break; 935 case 'Registration-Form-Newsletter-Error': 936 pushRegistrationFormError('newsletter'); 937 break; 938 case 'Sign-In-Error': 939 pushSignInEvent('Sign-In-Error'); 940 break; 941 case 'Sign-In-Success': 942 pushPianoConnectionEvent('sign in'); 943 pushSignInEvent('Sign-In-Success'); 944 break; 945 case 'Restore-Form-Success': 946 pushPianoConnectionEvent('restore password'); 947 break; 948 case 'Restore-Form-Error': 949 pushRestoreFormError(); 950 break; 951 case 'Paywall - Sign in - Click': 952 pushPaywallInteraction('sign in'); 953 break; 954 case 'Restore-Password-Back-To-Login': 955 pushPianoConnectionEvent('restore-password-back-login'); 956 break; 957 case 'Subscribe-Ribbon-Clicked': 958 pushSubscribeEvent({ 959 subscriptionLevelId: undefined, 960 subscriptionLevelName: undefined, 961 interactionArea: 'paywall' 962 }); 963 break; 964 } 965 }); 966}; 967 968 const getCookiesAccepted = () => { 969 try { 970 const getOptanonConsentCookie = () => { 971 const cookies = document.cookie.split('; '); 972 const cookie = cookies.find(item => item.startsWith('OptanonConsent=')); 973 if (!cookie) return undefined; 974 const equalIndex = cookie.indexOf('='); 975 return equalIndex !== -1 ? cookie.substring(equalIndex + 1) : undefined; 976 }; 977 const cookieValue = getOptanonConsentCookie(); 978 if (!cookieValue) { 979 return undefined; 980 } 981 const decodedValue = decodeURIComponent(cookieValue); 982 const groupsMatch = decodedValue.match(/groups=([^&]+)/); 983 if (!groupsMatch) { 984 return undefined; 985 } 986 const groupsEncoded = groupsMatch[1]; 987 const groups = decodeURIComponent(groupsEncoded); 988 const groupPairs = groups.split(','); 989 const groupValues = groupPairs.map(pair => { 990 const parts = pair.split(':'); 991 return parts.length === 2 ? parseInt(parts[1], 10) : null; 992 }).filter(val => val !== null); 993 if (groupValues.length === 0) { 994 return undefined; 995 } 996 const allOnes = groupValues.every(val => val === 1); 997 const allZeros = groupValues.every(val => val === 0); 998 const firstIsOne = groupValues[0] === 1; 999 const restAreZeros = groupValues.slice(1).every(val => val === 0); 1000 if (allOnes) { 1001 return 'all'; 1002 } 1003 if (allZeros || firstIsOne && restAreZeros) { 1004 return 'none'; 1005 } 1006 return 'some'; 1007 } catch (error) { 1008 return undefined; 1009 } 1010}; 1011 1012 const getRegionVariant = (arcSite, consolidationWebsites) => { 1013 try { 1014 const isConsolidatedWebsite = consolidationWebsites.includes(arcSite); 1015 if (!isConsolidatedWebsite) { 1016 return undefined; 1017 } 1018 const validRegions = ['noam', 'emea', 'apac', 'latam']; 1019 const editionCookie = document.cookie.split('; ').find(item => item.startsWith('edition=')).split('=')[1]; 1020 if (editionCookie && validRegions.includes(editionCookie)) { 1021 return editionCookie; 1022 } 1023 return undefined; 1024 } catch (error) { 1025 console.warn('[Data Layer] Error in getRegionVariant: ', error); 1026 return undefined; 1027 } 1028}; 1029 1030 const getCookiesRegion = () => { 1031 try { 1032 const type = window?.OneTrust?.GetDomainData()?.ConsentIntegrationData?.consentPayload?.dsDataElements?.Country; 1033 return type ? sanitizeGtmValue(type) : undefined; 1034 } catch (error) { 1035 return undefined; 1036 } 1037}; 1038 1039 const initOptanonWrapper = () => { 1040 const prevOptanonWrapper = window.OptanonWrapper; 1041 window.OptanonWrapper = function () { 1042 if (typeof prevOptanonWrapper === 'function') {
1043 try { 1044 prevOptanonWrapper(); 1045 } catch (error) { 1046 console.warn('[Data Layer] Error calling previous OptanonWrapper:', error); 1047 } 1048 } 1049 updateDataLayerWithCookiesRegion(); 1050 }; 1051 window.OptanonConsentChanged = function () { 1052 updateDataLayerWithCookiesRegion(); 1053 }; 1054 const handleOneTrustEvent = () => { 1055 updateDataLayerWithCookiesRegion(); 1056 }; 1057 if (window.dataLayer && Array.isArray(window.dataLayer)) { 1058 const originalPush = window.dataLayer.push; 1059 window.dataLayer.push = function (...args) { 1060 const result = originalPush.apply(this, args); 1061 if (args.length > 0 && args[0]) { 1062 const event = args[0].event; 1063 if (event === 'OneTrustGroupsUpdated' || event === 'OptanonLoaded') { 1064 setTimeout(() => { 1065 handleOneTrustEvent(); 1066 }, 100); 1067 } 1068 } 1069 return result; 1070 }; 1071 } 1072 if (window.OneTrust && window.OptanonWrapper && !window.OptanonWrapper.executed) { 1073 window.OptanonWrapper(); 1074 } 1075}; 1076 1077 const scrollTracking = () => { 1078 if (typeof window === 'undefined' || typeof document === 'undefined') return; 1079 const scrollThresholds = [0, 25, 50, 75, 100]; 1080 let triggeredThresholds = new Set(); 1081 let scrollBasePosition = 0; 1082 let isTrackingNewContent = false; 1083 let hasUserScrolled = false; 1084 const getDocHeight = () => { 1085 return Math.max(document.body.scrollHeight, document.documentElement.scrollHeight, document.body.offsetHeight, document.documentElement.offsetHeight, document.body.clientHeight, document.documentElement.clientHeight); 1086 }; 1087 const requiresScroll = () => { 1088 const docHeight = getDocHeight(); 1089 const winHeight = window.innerHeight || document.documentElement.clientHeight; 1090 return docHeight > winHeight; 1091 }; 1092 const checkForResetFlag = () => { 1093 if (typeof localStorage === 'undefined') return false; 1094 try { 1095 const resetFlag = localStorage.getItem('gtm_scroll_reset_needed'); 1096 if (resetFlag === 'true') { 1097 localStorage.removeItem('gtm_scroll_reset_needed'); 1098 return true; 1099 } 1100 } catch (error) { 1101 console.warn('[Data Layer] Error checking reset flag:', error); 1102 } 1103 return false; 1104 }; 1105 const initializeNewContentTracking = () => { 1106 const currentScrollTop = window.scrollY || document.documentElement.scrollTop; 1107 scrollBasePosition = currentScrollTop; 1108 isTrackingNewContent = true; 1109 hasUserScrolled = false; 1110 triggeredThresholds = new Set(); 1111 if (!triggeredThresholds.has(0)) { 1112 triggeredThresholds.add(0); 1113 pushScrollEvent(0); 1114 } 1115 }; 1116 const getScrollDepthForNewContent = () => { 1117 if (!isTrackingNewContent) return null; 1118 const currentScrollTop = window.scrollY || document.documentElement.scrollTop; 1119 const winHeight = window.innerHeight || document.documentElement.clientHeight; 1120 const currentDocHeight = getDocHeight(); 1121 const remainingHeight = currentDocHeight - scrollBasePosition; 1122 const visibleBottom = currentScrollTop + winHeight; 1123 const scrolledHeight = visibleBottom - scrollBasePosition; 1124 if (remainingHeight <= 0) return null; 1125 const scrollPercent = scrolledHeight / remainingHeight * 100; 1126 return Math.min(Math.max(Math.round(scrollPercent), 0), 100); 1127 }; 1128 const pushScrollEvent = depth => { 1129 try { 1130 window.dataLayer = window.dataLayer || []; 1131 window.dataLayer.push({ 1132 event: 'scroll', 1133 interaction_value: sanitizeGtmValue(`${depth}%`) 1134 }); 1135 } catch (error) { 1136 console.warn('[Data Layer] Scroll tracking error:', error); 1137 } 1138 }; 1139 const checkScroll = () => { 1140 if (checkForResetFlag()) { 1141 initializeNewContentTracking(); 1142 } 1143 if (!requiresScroll()) { 1144 if (!isTrackingNewContent && !triggeredThresholds.has(0)) { 1145 triggeredThresholds.add(0); 1146 pushScrollEvent(0); 1147 } 1148 return; 1149 } 1150 if (isTrackingNewContent) { 1151 const currentScrollTop = window.scrollY || document.documentElement.scrollTop; 1152 if (!hasUserScrolled && Math.abs(currentScrollTop - scrollBasePosition) < 1) { 1153 return; 1154 } 1155 hasUserScrolled = true; 1156 const relativeDepth = getScrollDepthForNewContent(); 1157 if (relativeDepth === null) return; 1158 scrollThresholds.forEach(threshold => { 1159 if (relativeDepth >= threshold && !triggeredThresholds.has(threshold)) { 1160 triggeredThresholds.add(threshold); 1161 pushScrollEvent(threshold); 1162 } 1163 }); 1164 } else { 1165 const scrollTop = window.scrollY || document.documentElement.scrollTop; 1166 const docHeight = getDocHeight(); 1167 const winHeight = window.innerHeight || document.documentElement.clientHeight; 1168 const scrollPercent = (scrollTop + winHeight) / docHeight * 100; 1169 const absoluteDepth = Math.min(Math.round(scrollPercent), 100); 1170 scrollThresholds.forEach(threshold => { 1171 if (absoluteDepth >= threshold && !triggeredThresholds.has(threshold)) { 1172 triggeredThresholds.add(threshold); 1173 pushScrollEvent(threshold); 1174 } 1175 }); 1176 } 1177 }; 1178 window.addEventListener('load', () => { 1179 if (!triggeredThresholds.has(0)) { 1180 triggeredThresholds.add(0); 1181 pushScrollEvent(0); 1182 } 1183 }); 1184 let ticking = false;
1185 window.addEventListener('scroll', () => { 1186 if (!ticking) { 1187 window.requestAnimationFrame(() => { 1188 checkScroll(); 1189 ticking = false; 1190 }); 1191 ticking = true; 1192 } 1193 }); 1194}; 1195 1196 const updateDataLayerWithCookiesRegion = () => { 1197 const tryUpdate = (attempts = 0) => { 1198 const cookiesRegion = getCookiesRegion(); 1199 if (cookiesRegion) { 1200 window.dataLayer = window.dataLayer || []; 1201 for (let i = window.dataLayer.length - 1; i >= 0; i--) { 1202 if (window.dataLayer[i] && window.dataLayer[i].event === 'page_view') { 1203 window.dataLayer[i].env_cookies_region = cookiesRegion; 1204 break; 1205 } 1206 } 1207 return; 1208 } 1209 if (attempts < 10) { 1210 setTimeout(() => { 1211 tryUpdate(attempts + 1); 1212 }, 200); 1213 } 1214 }; 1215 tryUpdate(); 1216}; 1217 1218 const updateArticleClickDataForGTM = () => { 1219 try { 1220 if (typeof window === 'undefined' || typeof localStorage === 'undefined') { 1221 return {}; 1222 } 1223 const result = {}; 1224 const updateJourneyData = (storageKey, gtmKey, allowUndefined = false) => { 1225 try { 1226 const storageValue = localStorage.getItem(storageKey); 1227 if (storageValue !== null) { 1228 if (allowUndefined && storageValue === 'undefined') { 1229 localStorage.removeItem(storageKey); 1230 result[gtmKey] = undefined; 1231 return true; 1232 } 1233 const value = storageKey === 'gtm_article_click_homepage_link_clicked' ? storageValue === 'true' ? true : storageValue : sanitizeGtmValue(storageValue); 1234 if (value !== undefined) { 1235 localStorage.removeItem(storageKey); 1236 result[gtmKey] = value; 1237 return true; 1238 } 1239 } 1240 } catch (error) { 1241 console.warn('[Data Layer] Error processing storage key:', storageKey, error); 1242 } 1243 return false; 1244 }; 1245 updateJourneyData('gtm_article_click_block_name', 'article_click_block_name'); 1246 updateJourneyData('gtm_article_click_page_type', 'article_click_page_type'); 1247 updateJourneyData('gtm_article_click_target_label', 'article_click_target_label'); 1248 updateJourneyData('gtm_article_click_homepage_heading', 'article_click_homepage_heading', true); 1249 updateJourneyData('gtm_article_click_homepage_link_clicked', 'article_click_homepage_link_clicked'); 1250 updateJourneyData('gtm_article_click_homepage_section', 'article_click_homepage_section', true); 1251 return Object.keys(result).length > 0 ? result : {}; 1252 } catch (error) { 1253 console.warn('[Data Layer] Error in updateArticleClickDataForGTM:', error); 1254 return {}; 1255 } 1256}; 1257 1258 const getAndClearStoredEvent = storageKey => { 1259 try { 1260 if (typeof window === 'undefined' || typeof localStorage === 'undefined') { 1261 return null; 1262 } 1263 const storedEvent = localStorage.getItem(storageKey); 1264 if (storedEvent) { 1265 try { 1266 const eventData = JSON.parse(storedEvent); 1267 localStorage.removeItem(storageKey); 1268 return eventData; 1269 } catch (error) { 1270 console.warn(`[Data Layer] Error parsing ${storageKey}:`, error); 1271 localStorage.removeItem(storageKey); 1272 } 1273 } 1274 } catch (error) { 1275 console.warn(`[Data Layer] Error in getAndClearStoredEvent for ${storageKey}:`, error); 1276 } 1277 return null; 1278}; 1279 1280 const updateFormSubmissionDataForGTM = () => getAndClearStoredEvent('gtm_form_submission_event'); 1281 1282 const updateSignInEventForGTM = () => getAndClearStoredEvent('gtm_sign_in_event'); 1283 1284 const checkAdBlocker = async () => { 1285 try { 1286 const ADBLOCK_REQUEST_URL = 'https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js'; 1287 const ADBLOCK_REQUEST_CONFIG = { 1288 method: 'HEAD', 1289 mode: 'no-cors' 1290 }; 1291 await fetch(ADBLOCK_REQUEST_URL, ADBLOCK_REQUEST_CONFIG); 1292 return false; 1293 } catch (error) { 1294 console.error('[GTM AdBlock] Check AdBlocker error:', error); 1295 return true; 1296 } 1297}; 1298 1299 const updateDataLayerWithAdBlocker = () => { 1300 checkAdBlocker().then(isBlocked => { 1301 try { 1302 window.dataLayer = window.dataLayer || []; 1303 for (let i = window.dataLayer.length - 1; i >= 0; i--) { 1304 if (window.dataLayer[i] && window.dataLayer[i].event === 'page_view') { 1305 window.dataLayer[i].env_ad_blocker = isBlocked; 1306 break; 1307 } 1308 } 1309 window.dataLayer.push({ 1310 env_ad_blocker: isBlocked 1311 }); 1312 } catch (error) { 1313 console.warn('[Data Layer] Error updating env_ad_blocker:', error); 1314 } 1315 }).catch(error => { 1316 console.warn('[Data Layer] Error in checkAdBlocker:', error); 1317 }); 1318}; 1319 1320 const updateDataLayerWithCurrency = currencyCode => { 1321 if (!currencyCode) return; 1322 try { 1323 window.dataLayer = window.dataLayer || []; 1324 for (let i = window.dataLayer.length - 1; i >= 0; i--) { 1325 if (window.dataLayer[i] && window.dataLayer[i].event === 'page_view') { 1326 window.dataLayer[i].env_currency = sanitizeGtmValue(currencyCode); 1327 break; 1328 } 1329 } 1330 } catch (error) { 1331 console.warn('[Data Layer] Error updating env_currency:', error); 1332 } 1333}; 1334 1335 const getCurrencyFromStorage = () => { 1336 try { 1337 if (typeof window === 'undefined' || typeof localStorage === 'undefined') { 1338 return undefined; 1339 } 1340 return localStorage.getItem('gtm_env_currency') || undefined; 1341 } catch (error) { 1342 console.warn('[Data Layer] Error in getCurrencyFromStorage:', error); 1343 return undefined; 1344 } 1345}; 1346 1347 const calculateDaysSince = dateStr => { 1348 if (!dateStr) return undefined; 1349 try { 1350 const parts = dateStr.split('/'); 1351 const date = new Date(parts[2], parts[1] - 1, parts[0]); 1352 const now = new Date(); 1353 const diff = now - date; 1354 return String(Math.floor(diff / (1000 * 60 * 60 * 24))); 1355 } catch (error) { 1356 return undefined; 1357 } 1358}; 1359 1360 const getUserType = () => { 1361 if (typeof window === 'undefined' || typeof localStorage === 'undefined') return 'visitor'; 1362 const loggedInStatus = localStorage.getItem('loggedInStatus'); 1363 if (!loggedInStatus || loggedInStatus === '0') return 'visitor'; 1364 try { 1365 const gtmUserData = localStorage.getItem('gtm_user_data'); 1366 if (!gtmUserData) return 'registered'; 1367 const userData = JSON.parse(gtmUserData); 1368 const subscriptionLevelName = userData.subscription_level_name; 1369 if (!subscriptionLevelName) return 'registered'; 1370 const lowerName = subscriptionLevelName.toLowerCase(); 1371 return lowerName.includes('subscription') ? 'subscriber' : 'registered'; 1372 } catch (error) { 1373 return 'registered'; 1374 } 1375}; 1376 1377 const mapUserDataToGTM = () => { 1378 if (typeof window === 'undefined' || typeof localStorage === 'undefined') { 1379 return {}; 1380 } 1381 const loggedInStatus = localStorage.getItem('loggedInStatus'); 1382 const isLoggedIn = loggedInStatus === '1'; 1383 if (!isLoggedIn) { 1384 return { 1385 user_logged: sanitizeGtmValue('logged out'), 1386 user_id: undefined, 1387 user_status: undefined,
1388 user_type: sanitizeGtmValue('visitor'), 1389 user_subscription: [], 1390 user_company_type: undefined, 1391 user_company_industry: undefined, 1392 user_department: undefined, 1393 user_company_responsibility: undefined, 1394 user_company_jobtitle: undefined, 1395 user_company_name: undefined, 1396 user_country: undefined 1397 }; 1398 } 1399 try { 1400 const gtmUserDataStr = localStorage.getItem('gtm_user_data'); 1401 if (!gtmUserDataStr) { 1402 return { 1403 user_logged: sanitizeGtmValue('logged in'), 1404 user_id: undefined, 1405 user_status: undefined, 1406 user_type: sanitizeGtmValue('registered'), 1407 user_subscription: [], 1408 user_company_type: undefined, 1409 user_company_industry: undefined, 1410 user_department: undefined, 1411 user_company_responsibility: undefined, 1412 user_company_jobtitle: undefined, 1413 user_company_name: undefined, 1414 user_country: undefined 1415 }; 1416 } 1417 const gtmUserData = JSON.parse(gtmUserDataStr); 1418 const subscriptionLevelNames = gtmUserData.subscription_level_name ? gtmUserData.subscription_level_name.split('|') : []; 1419 const subscriptionLevels = gtmUserData.subscription_level ? gtmUserData.subscription_level.split('|') : []; 1420 const startDates = gtmUserData.start_date ? gtmUserData.start_date.split('|') : []; 1421 const endDates = gtmUserData.end_date ? gtmUserData.end_date.split('|') : []; 1422 const daysLeft = gtmUserData.days_left_on_subscription ? gtmUserData.days_left_on_subscription.split('|') : []; 1423 const userSubscriptions = subscriptionLevelNames.map((name, index) => ({ 1424 level_id: sanitizeGtmValue(subscriptionLevels[index]), 1425 level_name: sanitizeGtmValue(name), 1426 start_date: sanitizeGtmValue(startDates[index]), 1427 end_date: sanitizeGtmValue(endDates[index]), 1428 days_since_last: calculateDaysSince(startDates[index]), 1429 days_left: sanitizeGtmValue(daysLeft[index]) 1430 })); 1431 const userType = getUserType(); 1432 const isNew = subscriptionLevelNames.length <= 1; 1433 return { 1434 user_logged: sanitizeGtmValue('logged in'), 1435 user_id: sanitizeGtmValue(gtmUserData.registered_user_id), 1436 user_status: isNew, 1437 user_type: sanitizeGtmValue(userType), 1438 user_subscription: userSubscriptions, 1439 user_company_type: sanitizeGtmValue(gtmUserData.company_type), 1440 user_company_industry: sanitizeGtmValue(gtmUserData.industry), 1441 user_department: sanitizeGtmValue(gtmUserData.user_department), 1442 user_company_responsibility: sanitizeGtmValue(gtmUserData.responsibility), 1443 user_company_jobtitle: sanitizeGtmValue(gtmUserData.job_title), 1444 user_company_name: sanitizeGtmValue(gtmUserData.company), 1445 user_country: sanitizeGtmValue(gtmUserData.country) 1446 }; 1447 } catch (error) { 1448 console.warn('[GTM User Data] Error parsing user data from localStorage:', error); 1449 return { 1450 user_logged: sanitizeGtmValue('logged in'), 1451 user_id: undefined, 1452 user_status: undefined, 1453 user_type: sanitizeGtmValue('registered'), 1454 user_subscription: [], 1455 user_company_type: undefined, 1456 user_company_industry: undefined, 1457 user_department: undefined, 1458 user_company_responsibility: undefined, 1459 user_company_jobtitle: undefined, 1460 user_company_name: undefined, 1461 user_country: undefined 1462 }; 1463 } 1464}; 1465 1466 const findTargetSupplierSection = (sections = []) => { 1467 return sections.find(section => { 1468 const navigation = section.additional_properties?.original?.navigation ?? {}; 1469 return navigation.type === 'supplier' && navigation.root_section === 'false'; 1470 }); 1471}; 1472 1473 const findCurrentCampaign = (arcSite, basicItems) => { 1474 if (!basicItems || !Array.isArray(basicItems)) { 1475 return null; 1476 } 1477 return basicItems.find((item = {}) => { 1478 if (item.subtype !== 'campaign') return false; 1479 const { 1480 embed: { 1481 config: { 1482 startDate, 1483 endDate, 1484 site 1485 } = {} 1486 } = {} 1487 } = item; 1488 if (!startDate || !endDate) return false; 1489 const startTimestamp = new Date(startDate).getTime(); 1490 const endTimestamp = new Date(endDate).getTime(); 1491 const currentTimestamp = new Date().getTime(); 1492 return arcSite === site?.value && currentTimestamp >= startTimestamp && currentTimestamp <= endTimestamp; 1493 }); 1494}; 1495 1496 const determinePageTypeFromContent = globalContent => { 1497 const LEADGEN_PAGE = 'leadgen page';
1498 const COMPANY_PAGE = 'company page'; 1499 const INTERNAL_WEBINAR = 'event page - internal webinar'; 1500 const SUPPLIER_WEBINER = 'event page - supplier webinar'; 1501 const subtype = globalContent?.subtype; 1502 const hasInternalWebinar = globalContent?.promo_items?.event?.embed?.config?.internal_webinar; 1503 const hasSupplierWebinar = globalContent?.promo_items?.event?.embed?.config?.supplier_webinar; 1504 if (hasInternalWebinar) { 1505 return INTERNAL_WEBINAR; 1506 } 1507 if (hasSupplierWebinar) { 1508 return SUPPLIER_WEBINER; 1509 } 1510 if ([types_PRODUCT_FILE, types_PRODUCT_VIDEO, types_PRODUCT_LINK, types_PRODUCT_LONGREAD].includes(subtype)) { 1511 return LEADGEN_PAGE; 1512 } 1513 if ([types_SUPPLIER_TYPE].includes(subtype)) { 1514 return COMPANY_PAGE; 1515 } 1516 const sections = globalContent?.taxonomy?.sections ?? []; 1517 const targetSection = findTargetSupplierSection(sections); 1518 if (targetSection) { 1519 return COMPANY_PAGE; 1520 } 1521 return null; 1522}; 1523 1524 const buildFormSubmissionData = (globalContent, pageType) => { 1525 if (!globalContent || !pageType) return null; 1526 const LEADGEN_PAGE = 'leadgen page'; 1527 const COMPANY_PAGE = 'company page'; 1528 const INTERNAL_WEBINAR = 'event page - internal webinar'; 1529 const SUPPLIER_WEBINER = 'event page - supplier webinar'; 1530 const FORMAT_MAP = { 1531 [types_PRODUCT_FILE]: 'pdf', 1532 [types_PRODUCT_VIDEO]: 'video', 1533 [types_PRODUCT_LINK]: 'link', 1534 [types_PRODUCT_LONGREAD]: 'Long read', 1535 [types_SUPPLIER_WEBINAR]: 'External Webinar', 1536 [INTERNAL_WEBINAR]: 'Internal Webinar' 1537 }; 1538 const findTargetSupplierSectionLocal = sections => { 1539 if (!sections || !Array.isArray(sections)) return null; 1540 return sections.find(section => { 1541 const navigation = section?.additional_properties?.original?.navigation ?? {}; 1542 return navigation.type === 'supplier' && navigation.root_section === 'false'; 1543 }); 1544 }; 1545 const sections = globalContent?.taxonomy?.sections ?? []; 1546 const targetSection = findTargetSupplierSectionLocal(sections); 1547 const subtype = globalContent?.subtype; 1548 const format = FORMAT_MAP[subtype]; 1549 switch (pageType) { 1550 case LEADGEN_PAGE: 1551 { 1552 return { 1553 requested_content_company: sanitizeGtmValue(targetSection?.name), 1554 requested_content_format: sanitizeGtmValue(format ? format.toLowerCase() : format), 1555 requested_content_title: sanitizeGtmValue(globalContent?.headlines?.basic), 1556 requested_content_type: sanitizeGtmValue(globalContent?.label?.product_type?.text) 1557 }; 1558 } 1559 case COMPANY_PAGE: 1560 { 1561 return { 1562 requested_content_company: sanitizeGtmValue(targetSection?.name), 1563 requested_content_format: sanitizeGtmValue(format ? format.toLowerCase() : format), 1564 requested_content_title: sanitizeGtmValue(globalContent?.headlines?.basic), 1565 requested_content_type: sanitizeGtmValue(globalContent?.label?.product_type?.text) 1566 }; 1567 } 1568 case INTERNAL_WEBINAR: 1569 { 1570 return { 1571 requested_content_company: sanitizeGtmValue(globalContent?.canonical_website), 1572 requested_content_format: sanitizeGtmValue(format ? format.toLowerCase() : format), 1573 requested_content_title: sanitizeGtmValue(globalContent?.headlines?.basic), 1574 requested_content_type: sanitizeGtmValue(globalContent?.promo_items?.event?.embed?.config?.internal_webinar?.eventType) 1575 }; 1576 } 1577 case SUPPLIER_WEBINER: 1578 { 1579 return { 1580 requested_content_company: sanitizeGtmValue(targetSection?.name ?? 'Not available'), 1581 requested_content_format: sanitizeGtmValue(format ? format.toLowerCase() : format), 1582 requested_content_title: sanitizeGtmValue(globalContent?.headlines?.basic), 1583 requested_content_type: sanitizeGtmValue(globalContent?.promo_items?.event?.embed?.config?.supplier_webinar?.eventType) 1584 }; 1585 } 1586 default: 1587 return null; 1588 } 1589}; 1590 1591 const trackOutboundLinks = websiteDomain => { 1592 if (!websiteDomain) { 1593 return () => {}; 1594 } 1595 const handleOutboundClick = event => { 1596 if (!isDigitalDataAvailableForPA()) return; 1597 const target = event.target.closest('a'); 1598 if (!target || !target.href) return; 1599 try { 1600 const linkUrl = new URL(target.href); 1601 const currentDomain = new URL(websiteDomain).hostname; 1602 const linkDomain = linkUrl.hostname; 1603 const isExternal = linkDomain !== currentDomain; 1604 if (isExternal) { 1605 window.dataLayer.push({ 1606 event: 'outbound_link_click', 1607 interaction_details: target.href 1608 }); 1609 } 1610 } catch (error) { 1611 console.warn('[GTM Outbound Link] Invalid URL:', target.href, error); 1612 } 1613 }; 1614 document.addEventListener('click', handleOutboundClick); 1615 return () => { 1616 document.removeEventListener('click', handleOutboundClick); 1617 }; 1618}; 1619 1620 const waitForOneTrustReady = (timeout = 5000) => { 1621 return new Promise(resolve => { 1622 if (typeof window === 'undefined') { 1623 resolve(false); 1624 return; 1625 } 1626 const checkOneTrustReady = () => { 1627 const hasOneTrust = window.OneTrust && typeof window.OneTrust.GetDomainData === 'function'; 1628 const cookiesRegion = getCookiesRegion(); 1629 const isReady = hasOneTrust && cookiesRegion !== undefined; 1630 return isReady; 1631 }; 1632 if (checkOneTrustReady()) { 1633 resolve(true); 1634 return; 1635 } 1636 let resolved = false;
1637 const timeoutId = setTimeout(() => { 1638 if (!resolved) { 1639 resolved = true; 1640 resolve(false); 1641 } 1642 }, timeout); 1643 const checkOnEvent = () => { 1644 if (resolved) return; 1645 if (checkOneTrustReady()) { 1646 resolved = true; 1647 clearTimeout(timeoutId); 1648 resolve(true); 1649 } 1650 }; 1651 if (window.dataLayer && Array.isArray(window.dataLayer)) { 1652 const originalPush = window.dataLayer.push; 1653 const wrappedPush = function (...args) { 1654 const result = originalPush.apply(this, args); 1655 if (args.length > 0 && args[0]?.event) { 1656 const event = args[0].event; 1657 if (event === 'OneTrustLoaded' || event === 'OptanonLoaded' || event === 'OneTrustGroupsUpdated') { 1658 setTimeout(checkOnEvent, 100); 1659 } 1660 } 1661 return result; 1662 }; 1663 window.dataLayer.push = wrappedPush; 1664 } 1665 const intervalId = setInterval(() => { 1666 if (resolved) { 1667 clearInterval(intervalId); 1668 return; 1669 } 1670 if (checkOneTrustReady()) { 1671 resolved = true; 1672 clearTimeout(timeoutId); 1673 clearInterval(intervalId); 1674 resolve(true); 1675 } 1676 }, 100); 1677 }); 1678}; 1679 1680 const waitForComposerReady = (timeout = 3000) => { 1681 return new Promise(resolve => { 1682 if (typeof window === 'undefined') { 1683 resolve(false); 1684 return; 1685 } 1686 const checkReady = () => { 1687 return window.tp && window.tp.main && typeof window.tp.main.fetchPageViewId === 'function'; 1688 }; 1689 if (checkReady()) { 1690 resolve(true); 1691 return; 1692 } 1693 let resolved = false; 1694 const timeoutId = setTimeout(() => { 1695 if (!resolved) { 1696 resolved = true; 1697 resolve(false); 1698 } 1699 }, timeout); 1700 const intervalId = setInterval(() => { 1701 if (resolved) { 1702 clearInterval(intervalId); 1703 return; 1704 } 1705 if (checkReady()) { 1706 resolved = true; 1707 clearTimeout(timeoutId); 1708 clearInterval(intervalId); 1709 resolve(true); 1710 } 1711 }, 100); 1712 }); 1713}; 1714 1715 const getPianoIds = () => { 1716 const result = { 1717 env_composer_pageview_id: undefined, 1718 env_composer_browser_id: undefined 1719 }; 1720 try { 1721 if (window.tp?.main?.fetchPageViewId) { 1722 result.env_composer_pageview_id = window.tp.main.fetchPageViewId(); 1723 } 1724 } catch (e) { 1725 console.warn('[DataLayer] Failed to get pageview_id:', e); 1726 } 1727 try { 1728 if (window.tp?.util?.getBrowserId) { 1729 result.env_composer_browser_id = window.tp.util.getBrowserId(); 1730 } 1731 } catch (e) { 1732 console.warn('[DataLayer] Failed to get browser_id:', e); 1733 } 1734 return result; 1735}; 1736 1737 const detectGamLoaded = () => { 1738 try { 1739 return Boolean(window?.googletag && window.googletag['_loadStarted_']); 1740 } catch (error) { 1741 return false; 1742 } 1743}; 1744 1745 const getAdRenderedState = () => { 1746 if (window.gamAdRendered === undefined) { 1747 window.gamAdRendered = false; 1748 } 1749 return window.gamAdRendered === true; 1750}; 1751 1752 const pushAdRenderedUpdate = () => { 1753 if (!window.dataLayer) { 1754 window.dataLayer = []; 1755 } 1756 window.dataLayer.push({ 1757 event: 'ad_rendered', 1758 env_ad_rendered: true 1759 }); 1760 console.log('[GAM] env_ad_rendered pushed'); 1761}; 1762 1763 const initAdRenderedListener = () => { 1764 if (window.gamAdRenderListenerInitialized) { 1765 return; 1766 } 1767 window.gamAdRenderListenerInitialized = true; 1768 if (!window.googletag || !window.googletag.cmd) { 1769 console.log('[GAM] googletag not ready for slot listener'); 1770 return; 1771 } 1772 window.googletag.cmd.push(() => { 1773 const pubads = window.googletag?.pubads?.(); 1774 if (!pubads || !pubads.addEventListener || !pubads.removeEventListener) { 1775 console.log('[GAM] pubads not available for slot listener'); 1776 return; 1777 } 1778 const handleSlotRenderEnded = event => { 1779 if (!event || event.isEmpty !== false) { 1780 return; 1781 } 1782 if (window.gamAdRendered === true) { 1783 return; 1784 } 1785 window.gamAdRendered = true; 1786 console.log('[GAM] ad rendered'); 1787 pushAdRenderedUpdate(); 1788 pubads.removeEventListener('slotRenderEnded', handleSlotRenderEnded); 1789 }; 1790 pubads.addEventListener('slotRenderEnded', handleSlotRenderEnded); 1791 console.log('[GAM] slotRenderEnded listener attached'); 1792 }); 1793}; 1794 1795 const getBasePageViewData = () => { 1796 if (!window.dataLayer) return {}; 1797 const basePageView = window.dataLayer.find(item => item?.event === 'page_view'); 1798 if (!basePageView) return {}; 1799 const { 1800 env_work, 1801 env_language, 1802 env_country, 1803 env_platform, 1804 env_region_variant, 1805 env_ad_blocker, 1806 page_status, 1807 page_name, 1808 page_type, 1809 page_id 1810 } = basePageView; 1811 return { 1812 env_work, 1813 env_language, 1814 env_country, 1815 env_platform, 1816 env_region_variant, 1817 env_ad_blocker, 1818 page_status, 1819 page_name, 1820 page_type, 1821 page_id 1822 }; 1823}; 1824
1825 const getUpdatedEnvData = () => { 1826 const getCurrencyValue = () => { 1827 try { 1828 if (typeof localStorage === 'undefined') return undefined; 1829 return localStorage.getItem('gtm_env_currency') || undefined; 1830 } catch (error) { 1831 return undefined; 1832 } 1833 }; 1834 return { 1835 env_cookies_accepted: getCookiesAccepted(), 1836 env_cookies_region: getCookiesRegion(), 1837 env_currency: sanitizeGtmValue(getCurrencyValue()) 1838 }; 1839}; 1840 1841 const pushLoginFormPageView = () => { 1842 if (!dataLayer_isDigitalDataAvailableForPA()) return; 1843 const basePageView = getBasePageViewData(); 1844 const updatedEnvData = getUpdatedEnvData(); 1845 const userData = mapUserDataToGTM(); 1846 const pianoIds = getPianoIds(); 1847 window.dataLayer.push(Object.assign({}, basePageView, updatedEnvData, userData, pianoIds, { 1848 event: 'page_view', 1849 page_status: '200', 1850 page_name: sanitizeGtmValue('/login/login_form'), 1851 page_type: sanitizeGtmValue('login'), 1852 page_id: sanitizeGtmValue('login') 1853 })); 1854}; 1855 1856 const pushRegistrationFormPageView = () => { 1857 if (!dataLayer_isDigitalDataAvailableForPA()) return; 1858 1859 // Suppress when inside an active Piano checkout flow on the same pathname 1860 // (flag set by useCheckout.js on `checkoutStateChange`). Piano's inline 1861 // registration form fires `registrationDisplayed` during checkout state2, 1862 // which would duplicate the legitimate `registration and payment details` 1863 // page_view. Path comparison gives natural cleanup on navigation away. 1864 if (window.paInCheckoutFlowPath === window.location.pathname) return; 1865 const basePageView = getBasePageViewData(); 1866 const updatedEnvData = getUpdatedEnvData(); 1867 const userData = mapUserDataToGTM(); 1868 const pianoIds = getPianoIds(); 1869 window.dataLayer.push(Object.assign({}, basePageView, updatedEnvData, userData, pianoIds, { 1870 event: 'page_view', 1871 page_status: '200', 1872 page_name: sanitizeGtmValue('/registration/registration_form'), 1873 page_type: sanitizeGtmValue('registration'), 1874 page_id: undefined 1875 })); 1876}; 1877 1878 pianoEventListener(["https://experience.tinypass.com","https://id.tinypass.com","https://api.piano.io","https://buy.tinypass.com"]); 1879 1880 1881 initOptanonWrapper(); 1882 1883 scrollTracking(); 1884 1885 1886 const hasOneTrustScript = document.querySelector('script[data-domain-script]') !== null; 1887 1888 const sendPageView = () => { 1889 1890 const getCookie = (key) => { 1891 return document.cookie 1892 .split('; ') 1893 .find(item => item.startsWith(`${key}=`)) 1894 ?.split('=')[1]; 1895 } 1896 1897 1898 const utmParams = extractUtmParameters(); 1899 const hasUtmParams = Object.values(utmParams).some(value => value !== undefined); 1900 1901 const articleClickData = 'subject page' === 'article' ? updateArticleClickDataForGTM() : {}; 1902 const formSubmissionData = updateFormSubmissionDataForGTM(); 1903 const signInEventData = updateSignInEventForGTM(); 1904 const userData = mapUserDataToGTM(); 1905 1906 window.dataLayer = window.dataLayer || []; 1907 initAdRenderedListener(); 1908 1909 const gamLoaded = detectGamLoaded(); 1910 const adRendered = getAdRenderedState(); 1911 console.log('[GAM] env flags', gamLoaded, adRendered); 1912 1913 const articleData = {}; 1914 const leadgenData = {}; 1915 1916 const cookiesRegion = getCookiesRegion(); 1917 const cookiesAccepted = getCookiesAccepted(); 1918 const pianoIds = getPianoIds(); 1919 1920 const eventData = { 1921 event: 'page_view', 1922 env_work: sanitizeGtmValue('williamreed'), 1923 env_language: sanitizeGtmValue('en'), 1924 env_country: sanitizeGtmValue('no specific country'), 1925 env_region_variant: getRegionVariant('nutraingredients-v2', ["nutraingredients-v2","foodnavigator-v2"]), 1926 env_ad_blocker: undefined, 1927 env_deployment_id: window?.Fusion?.deployment,
1928 article_content_restriction_code: window?.Fusion?.globalContent?.content_restrictions?.content_code, 1929 env_cookies_region: cookiesRegion, 1930 env_cookies_accepted: cookiesAccepted, 1931 env_currency: sanitizeGtmValue(getCurrencyFromStorage()), 1932 env_platform: 'Arc XP', 1933 env_gam_loaded: sanitizeGtmValue(gamLoaded), 1934 env_ad_rendered: sanitizeGtmValue(adRendered), 1935 env_composer_pageview_id: pianoIds.env_composer_pageview_id, 1936 env_composer_browser_id: pianoIds.env_composer_browser_id, 1937 page_status: sanitizeGtmValue('200'), 1938 page_name: sanitizeGtmValue(document.location.pathname), 1939 page_type: sanitizeGtmValue('subject page'), 1940 page_id: sanitizeGtmValue('/news'), 1941 ...(hasUtmParams ? utmParams : {}), 1942 ...articleClickData, 1943 ...articleData, 1944 ...leadgenData, 1945 ...userData 1946 }; 1947 1948 const isSearchPage = '/news' === 'search'; 1949 if (isSearchPage) { 1950 window.addEventListener('searchDataReady', (e) => { 1951 window.dataLayer.push({ ...eventData, ...e.detail }); 1952 }); 1953 } else { 1954 window.dataLayer.push(eventData); 1955 } 1956 1957 if (formSubmissionData) { 1958 window.dataLayer.push(formSubmissionData); 1959 } 1960 1961 if (signInEventData) { 1962 window.dataLayer.push(signInEventData); 1963 } 1964 1965 updateDataLayerWithAdBlocker(); 1966 trackOutboundLinks('https://www.nutraingredients.com'); 1967 }; 1968 1969 const promises = [waitForComposerReady()]; 1970 if (hasOneTrustScript) { 1971 promises.push(waitForOneTrustReady()); 1972 } 1973 1974 Promise.all(promises).then(() => { 1975 sendPageView(); 1976 }); 1977 })(); 1978 </script>
1978<script>window.IS_MOBILE = window.IS_MOBILE ?? (window.innerWidth <= 768);</script>
1978</head><body style="--website-primary-color:#ef6820;--website-primary-color-rgb:239,104,32;--website-secondary-color:#eb5d10;--website-secondary-color-rgb:235,93,16;--website-button-background-color:#ffdd4a;--website-button-color:#fff;--website-button-label-color:#18181b;--website-button-mouse-over-color:#f5c800;--website-tertiary-color:#ef6820;--website-tertiary-color-rgb:239,104,32;--website-quaternary-color:#d9560f;--website-quaternary-color-rgb:217,86,15;--website-background-opacity:rgba(239, 104, 32, 0.05);--website-background-image:url(/pf/resources/no-image.svg?d=266);--website-plus-label-background:linear-gradient(245deg, #f48b56 14.18%, #ed467b 55.84%, #ed24d2 99.85%)"><noscript><iframe title="gtm" src="https://www.googletagmanager.com/ns.html?id=GTM-5M746TG6" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><noscript><iframe title="gtm-piano-analytics" src="https://wrss.nutraingredients.com/ns.html?id=GTM-KV8SCQPL" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
1978<script type="text/javascript"> 1979 clarity("set", "page_type", "Subject page"); 1980 </script>
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1989<header class="title-block"><h1 class="title-block-title title-block-lg">News</h1></header><div class="sub-categories-menu"><a class="sub-categories-menu-link" style="background-color:rgba(239,104,32,0.05);color:#18181b" href="/News/Brands-manufacturers/">Brands & manufacturers</a><a class="sub-categories-menu-link" style="background-color:rgba(239,104,32,0.05);color:#18181b" href="/News/Suppliers/">Suppliers</a><a class="sub-categories-menu-link" style="background-color:rgba(239,104,32,0.05);color:#18181b" href="/News/Research/">Research</a><a class="sub-categories-menu-link" style="background-color:rgba(239,104,32,0.05);color:#18181b" href="/News/Markets-trends/">Markets & trends</a><a class="sub-categories-menu-link" style="background-color:rgba(239,104,32,0.05);color:#18181b" href="/News/Regulation-policy/">Regulation & policy</a><button class="sub-categories-menu-link" style="background-color:#ef6820;color:#fff">+ Show All</button></div><div class="category-content-block"><header class="category-content-block-header" style="border-color:#ef6820"><h2 class="category-content-block-header-title category-content-block-header-title-lg">Brands & manufacturers</h2><a class="category-content-block-header-link" href="/News/Brands-manufacturers/" aria-label="Read more about Brands & manufacturers">More<p style="color:#ef6820">â</p></a></header><div class="category-content-block-stories category-content-block-stories-1"><article class="card card-lg"><a aria-label="Read more about Womenâs health boom puts science communication under the microscope" class="c-link card-image-link" href="/Article/2026/09/24/womens-health-boom-puts-science-communication-under-the-microscope/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/7MEE54DELFBEZFDRP3UQGBY4KE.png?auth=fda20f96dc180b674d617a2fdd4cfd0703eae02c0fdc54779af8d8e003520701&width=607&height=341&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/7MEE54DELFBEZFDRP3UQGBY4KE.png?auth=fda20f96dc180b674d617a2fdd4cfd0703eae02c0fdc54779af8d8e003520701&width=607&height=341&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/7MEE54DELFBEZFDRP3UQGBY4KE.png?auth=fda20f96dc180b674d617a2fdd4cfd0703eae02c0fdc54779af8d8e003520701&width=768&height=432&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Womenâs health boom puts science communication under the microscope" src="https://www.nutraingredients.com/resizer/v2/7MEE54DELFBEZFDRP3UQGBY4KE.png?auth=fda20f96dc180b674d617a2fdd4cfd0703eae02c0fdc54779af8d8e003520701&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Womenâs health boom puts science communication under the microscope" class="c-link card-text-headline-link" href="/Article/2026/09/24/womens-health-boom-puts-science-communication-under-the-microscope/">Womenâs health boom puts science communication under the microscope</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-24T12:26:42.916Z">24-Sep-2026</time><span>By<!-- -->Â <!-- -->Cassandra Stern</span></p></div></article><article class="card card-lg"><a aria-label="Read more about Elixinol Wellness to acquire Vitable amid global interest in personalized health" class="c-link card-image-link" href="/Article/2026/09/24/elixinol-wellness-plans-to-buy-personalized-nutrition-firm-vitable/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/YNNERZIEZVLKLKQHLL23V7EX54.jpg?auth=fc8580118d4b2a03f7a4160d92ce106dc61c2362c5340933493cea585f85e2ba&width=229&height=129&smart=true" media="(min-width: 1059px)"/>
1989<source srcSet="https://www.nutraingredients.com/resizer/v2/YNNERZIEZVLKLKQHLL23V7EX54.jpg?auth=fc8580118d4b2a03f7a4160d92ce106dc61c2362c5340933493cea585f85e2ba&width=100&height=100&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/YNNERZIEZVLKLKQHLL23V7EX54.jpg?auth=fc8580118d4b2a03f7a4160d92ce106dc61c2362c5340933493cea585f85e2ba&width=80&height=80&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Elixinol Wellness to acquire Vitable amid global interest in personalized health" src="https://www.nutraingredients.com/resizer/v2/YNNERZIEZVLKLKQHLL23V7EX54.jpg?auth=fc8580118d4b2a03f7a4160d92ce106dc61c2362c5340933493cea585f85e2ba&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Elixinol Wellness to acquire Vitable amid global interest in personalized health" class="c-link card-text-headline-link" href="/Article/2026/09/24/elixinol-wellness-plans-to-buy-personalized-nutrition-firm-vitable/">Elixinol Wellness to acquire Vitable amid global interest in personalized health</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-24T03:59:49.701Z">24-Sep-2026</time><span>By<!-- -->Â <!-- -->Tingmin Koe</span></p></div></article><article class="card card-lg"><a aria-label="Read more about Industry faces trust test as AI reshapes health information" class="c-link card-image-link" href="/Article/2026/09/23/nutrition-brands-must-rethink-trust-in-the-ai-era/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/BYDGMHMUQZEZFBETITS3MRMPOY.jpg?auth=c119bac93a2c07580b3ab64ca43b9f7caabc213e96894dbb611f5fcacc4d5c34&width=229&height=129&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/BYDGMHMUQZEZFBETITS3MRMPOY.jpg?auth=c119bac93a2c07580b3ab64ca43b9f7caabc213e96894dbb611f5fcacc4d5c34&width=100&height=100&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/BYDGMHMUQZEZFBETITS3MRMPOY.jpg?auth=c119bac93a2c07580b3ab64ca43b9f7caabc213e96894dbb611f5fcacc4d5c34&width=80&height=80&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Industry faces trust test as AI reshapes health information" src="https://www.nutraingredients.com/resizer/v2/BYDGMHMUQZEZFBETITS3MRMPOY.jpg?auth=c119bac93a2c07580b3ab64ca43b9f7caabc213e96894dbb611f5fcacc4d5c34&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Industry faces trust test as AI reshapes health information" class="c-link card-text-headline-link" href="/Article/2026/09/23/nutrition-brands-must-rethink-trust-in-the-ai-era/">Industry faces trust test as AI reshapes health information</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-23T10:34:24.909Z">23-Sep-2026</time><span>By<!-- -->Â <!-- -->Olivia Haslam</span></p></div></article><article class="card card-lg"><a aria-label="Read more about Lifestream sees vision-brain dual care as key innovation driver for eye supplements" class="c-link card-image-link" href="/Article/2026/09/23/lifestream-sees-vision-brain-dual-care-as-key-innovation-driver-for-eye-supplements/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source 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loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Lifestream sees vision-brain dual care as key innovation driver for eye supplements" class="c-link card-text-headline-link" href="/Article/2026/09/23/lifestream-sees-vision-brain-dual-care-as-key-innovation-driver-for-eye-supplements/">Lifestream sees vision-brain dual care as key innovation driver for eye supplements</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-23T02:27:42.465Z">23-Sep-2026</time><span>By<!-- -->Â <!-- -->Hui Ling Dang</span></p></div></article></div></div><div align="center" id="leaderboard-dynamic-0" class="ad-banner leaderboard-dynamic placeholder-leaderboard-dynamic" role="button" tabindex="0"></div>
1989<script> 1990 (function() { 1991 var el = document.getElementById('leaderboard-dynamic-0'); 1992 if (!el) return; 1993 el.classList.remove('leaderboard-dynamic', 'rectangle-dynamic', 'placeholder-leaderboard-dynamic', 'placeholder-rectangle-dynamic'); 1994 el.classList.add(window.IS_MOBILE ? 'rectangle-dynamic' : 'leaderboard-dynamic'); 1995 el.classList.add(window.IS_MOBILE ? 'placeholder-rectangle-dynamic' : 'placeholder-leaderboard-dynamic'); 1996 1997 })(); 1998 </script>
1998<div class="category-content-block"><header class="category-content-block-header" style="border-color:#ef6820"><h2 class="category-content-block-header-title category-content-block-header-title-lg">Partner Feature</h2><a class="category-content-block-header-link" href="/News/Promotional-features/North-America/" aria-label="Read more about Partner Feature">More<p style="color:#ef6820">â</p></a></header><div class="category-content-block-stories category-content-block-stories-2"><article class="card card-lg"><a aria-label="Read more about Omega-3âs emerging role in the GLP-1 nutrition conversation" class="c-link card-image-link" href="/News/Promotional-features/nu-mega-explores-omega-3-and-muscle-health-during-glp-1-use/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/MC56VTXEC5FBBHUOLXWMF46WNM.png?auth=186362d604669ea20698bc3fa42ce62b0e3f6d7a16780084e1627cd98e4849c2&width=294&height=165&focal=632%2C172" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/MC56VTXEC5FBBHUOLXWMF46WNM.png?auth=186362d604669ea20698bc3fa42ce62b0e3f6d7a16780084e1627cd98e4849c2&width=238&height=134&focal=632%2C172" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/MC56VTXEC5FBBHUOLXWMF46WNM.png?auth=186362d604669ea20698bc3fa42ce62b0e3f6d7a16780084e1627cd98e4849c2&width=768&height=432&focal=632%2C172" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Omega-3âs emerging role in the GLP-1 nutrition conversation" src="https://www.nutraingredients.com/resizer/v2/MC56VTXEC5FBBHUOLXWMF46WNM.png?auth=186362d604669ea20698bc3fa42ce62b0e3f6d7a16780084e1627cd98e4849c2&focal=632%2C172" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Omega-3âs emerging role in the GLP-1 nutrition conversation" class="c-link card-text-headline-link" href="/News/Promotional-features/nu-mega-explores-omega-3-and-muscle-health-during-glp-1-use/">Omega-3âs emerging role in the GLP-1 nutrition conversation</a></h2><p class="card-text-info">In paid partnership with<!-- --> <!-- -->Nu-Mega Ingredients</p></div></article><article class="card card-lg"><a aria-label="Read more about Ashwagandha: Why science, regulation and transparency matter more than ever" class="c-link card-image-link" href="/News/Promotional-features/ashwagandha-science-regulation-and-transparency/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/QBJEAL54A5HEDE52RGW7XWFZ6Y.jpg?auth=e943760046cbf4fe6bb9c52f4a4122abb5ec9f3915608f0e281dc262fca70356&width=294&height=165&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/QBJEAL54A5HEDE52RGW7XWFZ6Y.jpg?auth=e943760046cbf4fe6bb9c52f4a4122abb5ec9f3915608f0e281dc262fca70356&width=238&height=134&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/QBJEAL54A5HEDE52RGW7XWFZ6Y.jpg?auth=e943760046cbf4fe6bb9c52f4a4122abb5ec9f3915608f0e281dc262fca70356&width=80&height=80&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Ashwagandha: Why science, regulation and transparency matter more than ever" src="https://www.nutraingredients.com/resizer/v2/QBJEAL54A5HEDE52RGW7XWFZ6Y.jpg?auth=e943760046cbf4fe6bb9c52f4a4122abb5ec9f3915608f0e281dc262fca70356&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Ashwagandha: Why science, regulation and transparency matter more than ever" class="c-link card-text-headline-link" href="/News/Promotional-features/ashwagandha-science-regulation-and-transparency/">Ashwagandha: Why science, regulation and transparency matter more than ever</a></h2><p class="card-text-info">In paid partnership with<!-- --> <!-- -->KSM-66 Ashwagandha & SRI-81 Shatavari</p></div></article><article class="card card-lg">
1998<a aria-label="Read more about Spotlight On... Ashwagandha: Understanding the Science, Scrutiny and Standards " class="c-link card-image-link" href="/News/Promotional-features/ashwagandha-industry-advocating-for-science-based-standard-to-address-regulatory-questions/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/IK53UBKVN5EWRDM4MWDQ3AHGOY.png?auth=3be1598da8bb3a830211f2d32130f373ba2c54df989a25807dee3fb525551d43&width=294&height=165&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/IK53UBKVN5EWRDM4MWDQ3AHGOY.png?auth=3be1598da8bb3a830211f2d32130f373ba2c54df989a25807dee3fb525551d43&width=238&height=134&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/IK53UBKVN5EWRDM4MWDQ3AHGOY.png?auth=3be1598da8bb3a830211f2d32130f373ba2c54df989a25807dee3fb525551d43&width=80&height=80&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Spotlight On... Ashwagandha: Understanding the Science, Scrutiny and Standards " src="https://www.nutraingredients.com/resizer/v2/IK53UBKVN5EWRDM4MWDQ3AHGOY.png?auth=3be1598da8bb3a830211f2d32130f373ba2c54df989a25807dee3fb525551d43&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Spotlight On... Ashwagandha: Understanding the Science, Scrutiny and Standards " class="c-link card-text-headline-link" href="/News/Promotional-features/ashwagandha-industry-advocating-for-science-based-standard-to-address-regulatory-questions/">
1998Spotlight On... Ashwagandha: Understanding the Science, Scrutiny and Standards </a></h2><p class="card-text-info">In paid partnership with<!-- --> <!-- -->Kerry</p></div></article><article class="card card-lg"><a aria-label="Read more about Personalized wellness solutions: Full-stack supplement innovation " class="c-link card-image-link" href="/News/Promotional-features/branded-ingredients-become-a-strategic-advantage-in-supplement-innovation/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/XKKNV7PUI5EXTMGPBUTWRWPBZ4.jpg?auth=047ff7595f84daf00dbf2c7c1c00f788560fef048fdea858805dbbe3f4522e06&width=294&height=165&focal=732%2C186" media="(min-width: 1059px)"/><source 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card-image-link" href="/Article/2026/09/23/how-ancient-nutrition-is-building-regenerative-supply-from-farm-to-shelf/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/MWSAVXHPKVCIFGQLF6EJY3VVNY.jpg?auth=f0fd82cd5f33348f2058e808c99ac4dadb3318b7cab2b1e941df90609f61018c&width=229&height=129&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/MWSAVXHPKVCIFGQLF6EJY3VVNY.jpg?auth=f0fd82cd5f33348f2058e808c99ac4dadb3318b7cab2b1e941df90609f61018c&width=100&height=100&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/MWSAVXHPKVCIFGQLF6EJY3VVNY.jpg?auth=f0fd82cd5f33348f2058e808c99ac4dadb3318b7cab2b1e941df90609f61018c&width=80&height=80&smart=true" media="(max-width: 768px)"/><img 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dateTime="2026-09-23T14:35:20.879Z">23-Sep-2026</time><span>By<!-- -->Â <!-- -->Asia Sherman</span></p></div></article></div></div><div align="center" id="leaderboard-dynamic-2" class="ad-banner leaderboard-dynamic placeholder-leaderboard-dynamic" role="button" tabindex="0"></div>
2007<script> 2008 (function() { 2009 var el = document.getElementById('leaderboard-dynamic-2'); 2010 if (!el) return; 2011 el.classList.remove('leaderboard-dynamic', 'rectangle-dynamic', 'placeholder-leaderboard-dynamic', 'placeholder-rectangle-dynamic'); 2012 el.classList.add(window.IS_MOBILE ? 'rectangle-dynamic' : 'leaderboard-dynamic'); 2013 el.classList.add(window.IS_MOBILE ? 'placeholder-rectangle-dynamic' : 'placeholder-leaderboard-dynamic'); 2014 2015 })(); 2016 </script>
2016<div class="category-content-block"><header class="category-content-block-header" style="border-color:#ef6820"><h2 class="category-content-block-header-title category-content-block-header-title-lg">Regulation & policy</h2><a class="category-content-block-header-link" href="/News/Regulation-policy/" aria-label="Read more about Regulation & policy">More<p style="color:#ef6820">â</p></a></header><div class="category-content-block-stories category-content-block-stories-3"><article class="card card-lg"><a aria-label="Read more about New Jersey legislator introduces restrictive supplements bill" class="c-link card-image-link" href="/Article/2026/09/24/new-jersey-legislator-introduces-restrictive-supplements-bill/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/WQBBGMZ6L5AHNA5PQMOBSSGMG4.jpg?auth=f4af278f8bdfdcc543013d691df3a0f9728fe2e6910db7f9987e2f32a3f1bd6f&width=400&height=225&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/WQBBGMZ6L5AHNA5PQMOBSSGMG4.jpg?auth=f4af278f8bdfdcc543013d691df3a0f9728fe2e6910db7f9987e2f32a3f1bd6f&width=326&height=183&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/WQBBGMZ6L5AHNA5PQMOBSSGMG4.jpg?auth=f4af278f8bdfdcc543013d691df3a0f9728fe2e6910db7f9987e2f32a3f1bd6f&width=768&height=432&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="New Jersey legislator introduces restrictive supplements bill" src="https://www.nutraingredients.com/resizer/v2/WQBBGMZ6L5AHNA5PQMOBSSGMG4.jpg?auth=f4af278f8bdfdcc543013d691df3a0f9728fe2e6910db7f9987e2f32a3f1bd6f&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: New Jersey legislator introduces restrictive supplements bill" class="c-link card-text-headline-link" href="/Article/2026/09/24/new-jersey-legislator-introduces-restrictive-supplements-bill/">New Jersey legislator introduces restrictive supplements bill</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-24T12:20:39.615Z">24-Sep-2026</time><span>By<!-- -->Â <!-- -->Stephen Daniells</span></p></div></article><article class="card card-lg"><a aria-label="Read more about Kiwi government proposes new rules for supplement exports, industry voices support" class="c-link card-image-link" href="/Article/2026/09/24/new-zealand-proposes-to-allow-therapeutic-claims-for-health-supplement-exports/"><div class="card-image"><div class="custom-image-wrapper"><div class="custom-image-placeholder" style="background-image:url(/pf/resources/no-image.svg?d=266)"><picture><source srcSet="https://www.nutraingredients.com/resizer/v2/JOZO6CY6Y5C2HBLDRQRT2JIIKI.jpg?auth=fab97278b3e52c7d4b84b4718758172bea7ebebec5fccf3b56838c315b40d105&width=400&height=225&smart=true" media="(min-width: 1059px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/JOZO6CY6Y5C2HBLDRQRT2JIIKI.jpg?auth=fab97278b3e52c7d4b84b4718758172bea7ebebec5fccf3b56838c315b40d105&width=326&height=183&smart=true" media="(min-width: 769px) and (max-width: 1058px)"/><source srcSet="https://www.nutraingredients.com/resizer/v2/JOZO6CY6Y5C2HBLDRQRT2JIIKI.jpg?auth=fab97278b3e52c7d4b84b4718758172bea7ebebec5fccf3b56838c315b40d105&width=80&height=80&smart=true" media="(max-width: 768px)"/><img data-chromatic="ignore" alt="Kiwi government proposes new rules for supplement exports, industry voices support" src="https://www.nutraingredients.com/resizer/v2/JOZO6CY6Y5C2HBLDRQRT2JIIKI.jpg?auth=fab97278b3e52c7d4b84b4718758172bea7ebebec5fccf3b56838c315b40d105&smart=true" loading="lazy"/></picture></div></div></div></a><div class="card-text"><h2 class="card-text-headline card-text-headline-lg" style="color:#000"><a aria-label="Read more: Kiwi government proposes new rules for supplement exports, industry voices support" class="c-link card-text-headline-link" href="/Article/2026/09/24/new-zealand-proposes-to-allow-therapeutic-claims-for-health-supplement-exports/">Kiwi government proposes new rules for supplement exports, industry voices support</a></h2><p class="card-text-date-author card-text-date-author-lg"><time dateTime="2026-09-24T09:25:23.293Z">24-Sep-2026</time><span>By<!-- -->Â <!-- -->
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Was the finished formulation tested, or only an individual ingredient? And how can companies communicate promising research without getting ahead of the evidence?</i>"},{"_id":"JI5O46RTZJEKLO5ARS354TH7LY","additional_properties":{},"type":"text","content":"Those questions are at the center of the Council for Responsible Nutritionâs inaugural SciComms Connect symposium, which will bring scientific, product development and communications professionals together Oct. 6 in Carlsbad, California. The program, themed âBridging Science and Marketing to Advance Womenâs Vitality,â is part of CRNâs Signature Events and precedes Innovation Exchange and CONVERGENCE â26."},{"_id":"AXUTB5JCSRDDNHDVRIA54FEJOE","additional_properties":{},"type":"text","content":"Andrea Wong, Ph.D., senior vice president and chief science officer at CRN, said increased attention to womenâs health comes as consumers navigate an increasingly crowded information environment."},{"_id":"OY4IFQDHX5FJRF7J6NIFYQG2VM","additional_properties":{},"type":"text","content":"âFinally, womenâs health is getting the attention it deserves in terms of the scientific researchâ being conducted by academia and industry, she told NutraIngredients."},{"_id":"A2TXKRO6DRH4HOZCGXVQNKU24Q","additional_properties":{},"type":"text","content":"At the same time, she said, women are encountering overhyped messaging around everything from menopause to other health concerns."},{"_id":"LO6Z7GKSSJDGPMB25SEJGIHHQI","additional_properties":{},"type":"text","content":"âWe want to give our audience really practical tools for them to navigate this area, to look at the research,â Wong said. âWhat does it actually say? Donât overhype it, but donât undersell it either.â
2039"},{"level":2,"_id":"BT2H74OKD5CIFJ2TPTQFWTP47M","additional_properties":{},"type":"header","content":"Women are not one consumer"},{"_id":"HFB5KFRWIVDRNGANC54NZESU74","additional_properties":{},"type":"text","content":"CRN built the SciComms Connect agenda around several areas of womenâs health, including menopause and healthy aging, active nutrition and maternal health."},{"_id":"O42D3S6GARDNZHUZZHWFSZ47MU","additional_properties":{},"type":"text","content":"Jeff Ventura, vice president of communications at CRN, said one potential trap is treating womenâs health as a catch-all category despite differences across adolescence, reproductive years, pregnancy, postpartum, menopause and healthy aging."},{"_id":"76TAIBZIUNFR5OWUKTFB5QHHPQ","additional_properties":{},"type":"text","content":"That distinction matters when companies decide not only what to formulate but what evidence can reasonably support their products."},{"_id":"U67OWBXAMBD47GSHLIJTNJW2WY","additional_properties":{},"type":"text","content":"âWomen are not one homogeneous group, and the science, and the way we communicate it, should reflect that,â Heather Woolery-Lloyd, MD, FAAD, board-certified dermatologist and chief medical advisor at Nutrafol and speaker at the upcoming symposium, told NI. "},{"_id":"5XZCZEDNJJENFAD5TMWFWCE7V4","additional_properties":{},"type":"text","content":"Dr. Woolery-Lloyd pointed to hair health as an example. Hormones, stress, nutrition, aging and lifestyle can all play a role, making evidence on a popular individual ingredient less informative than research demonstrating that a specific formulation improved a defined outcome in its intended population."},{"level":2,"_id":"LFJCL5KQBJARTLN5HJ4PN4KNKY","additional_properties":{},"type":"header","content":"What does âclinically studiedâ mean?"},{"_id":"WKQGMLRFIBEXBFJOJB7TZUJIMI","additional_properties":{},"type":"text","content":"Ryan Woodbury, co-founder and co-CEO of maternal nutrition company Needed, raised a similar concern around the way evidence is communicated."},{"_id":"UKJMSBBYN5GOBOHGXFSSMFQ3HM","additional_properties":{},"type":"text","content":"Growing investment in womenâs health has helped bring research and product innovation to previously overlooked areas, she said, but terms such as âclinically studiedâ and âclinically provenâ can obscure important distinctions."},{"_id":"BCXZDTE2XZHDXITF5VNISLETAA","additional_properties":{},"type":"text","content":"âSometimes only one ingredient was studied, rather than the finished product, or it was tested at a different dose, in a different population or for a different outcome than the product claims,â Woodbury told NI. "},{"_id":"YZNZQXRE25F43FEM5DCTVOSOOI","additional_properties":{},"type":"text","content":"For companies, that creates a communications challenge alongside the scientific one."},{"_id":"7KQUNPHDBJEGHLEEG2UYVZ2VYE","additional_properties":{},"type":"text","content":"âWe have learned that our job is to make the truth compelling...we can simplify the language without changing the evidence by remaining clear about who was studied, what was measured and how certain the conclusion is,â she added. "},{"level":2,"_id":"E5R2WE4POBDVVF4RLBRX4EFBLE","additional_properties":{},"type":"header","content":"Closing the distance between science and consumers"},{"_id":"F476NKRZGVEX7HM5ATA4PTKM5E","additional_properties":{},"type":"text","content":"SciComms Connect grew out of CRNâs previously separate Science in Session and WellComms programs. Ventura said CRN noticed attendees moving between the scientific and communications sessions when the programs were held side by side, pointing to a need for more interaction between the disciplines."},{"_id":"AZWAFIQ25RCETMRCCTRDGJFGV4","additional_properties":{},"type":"text","content":"The resulting symposium is intended to serve as what he called the âconnective tissueâ between the science itself and how it is ultimately communicated to consumers."},{"_id":"VUEQITTYAZF3LHQXRXIAJXS34E","additional_properties":{},"type":"text","content":"That connection has become more complicated as consumers increasingly turn to
2039social media, influencers and artificial intelligence for health information, according to Ventura."},{"_id":"KAWK76BPABHHBARTTQSBW3OM7A","additional_properties":{},"type":"text","content":"âI think SciComms Connect ultimately is [â¦] figuring out how to sort of shorten the distance between the laboratory and the women who are trying to make decisions about their health,â he said."},{"_id":"ZIYUCENZURBNLAJZGMN56Q5CA4","additional_properties":{},"type":"text","content":"Wong said that work also needs to begin earlier within companies. Rather than handing a finished innovation to communications teams after formulation and legal and regulatory work are complete, she said scientific, regulatory, innovation and communications functions should work together throughout the process."},{"_id":"B5BYZLS7XBDQZFDSK6Y2RRFXEQ","additional_properties":{},"type":"text","content":"And despite the growing attention to womenâs health, significant scientific gaps remain."},{"_id":"HNJNZ4XAZZBIFMH6JRASGFACHY","additional_properties":{},"type":"text","content":"Wong pointed particularly to nutrition during the perimenopause and menopause transition and maternal health, including support for women during pregnancy and postpartum."},{"_id":"COFM2VQTYJHQBJ5LH4MHN3H6RQ","additional_properties":{},"type":"text","content":"âWeâre just at the tip of the iceberg in terms of all the hormonal shifts that are happening during the perimenopause, menopause transition,â she said. "},{"_id":"ILR5D3LQQJDUDDCCBOE33QN5EM","additional_properties":{},"type":"text","content":"âWeâre starting to understand a little bit more, but I think thereâs just so much.â"},{"_id":"OUPNL5RUPBAL7P7AILGKKJHNBI","additional_properties":{},"type":"text","content":"<i>For more information and to register, please click </i><a href=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\" target=\"_blank\" rel=\"\" title=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\"><i>here</i></a><i>. </i>"}],"subheadlines":{"basic":"CRNâs upcoming SciComms Connect symposium will highlight how womenâs health is attracting more research, investment, and product development, but translating that momentum into credible supplement products and consumer messaging remains challenging."},"description":{"basic":"The Council for Responsible Nutritionâs inaugural SciComms Connect symposium will address the challenges of translating growing research and investment in womenâs health into credible supplement products and consumer messaging. 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2039play/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/08/04/pg-to-acquire-thorne-in-premium-wellness-play/\">P&G, which acquired Thorne</a> to boost its personalized health portfolio for US$3.8bn in August 2026, and US company Hims & Hers Health, which also acquired Australiaâs Eucalyptus for up to US$1.15 billion in June 2026 to bring its personalized care service to international markets. "},{"_id":"TQQQCWPHKVBDRC3VDKLBZ7AHNU","additional_properties":{},"type":"text","content":"Direct customer relationships, recurring revenue and personalization are at the center of these deals. "},{"content_elements":[{"_id":"SX3ZEDHQX5FQJO4D7YTUNX2UJM","additional_properties":{},"type":"text","content":"Right now, weâre seeing some of the biggest names in global consumer health: Procter and Gamble, Nestle, Unilever, deploying billions of dollars into precisely this category â personalized subscription-led wellness. "},{"_id":"4MI2IK42GJCHZBU6ZPLC2VJFFI","additional_properties":{},"type":"text","content":"Weâre leaning into that same wave early and on terms that are genuinely disciplined for our shareholders, because thatâs the other thing I want you to hear clearly today. This is a capital light, largely deferred, performance-based structure. It protects our existing shareholders and it aligns Vitableâs team directly with the outcomes weâre all chasing together."},{"_id":"LPFMQ2ZUTZEVTIMNOOBUR7BXLU","additional_properties":{},"type":"text","content":"After a really challenging period of financial reset and fixing the underlying P&L, the exit of the non-core and underperforming US CBD business, weâre now starting to scale via acquisition, just as we told the market we would."}],"citation":{"type":"text","content":"Gavin Evans, independent non-executive chairman of Elixinol Wellness "},"subtype":"pullquote","_id":"O4W2IDWKJBCGPFKYROBHIDAS6Y","additional_properties":{"language":{"code":"en","region":"GB"}},"type":"quote"},{"level":2,"_id":"5EBDHV3AB5FERONXP7J7Y5RFGY","additional_properties":{},"type":"header","content":"Vitable to add over $5m of revenue "},{"_id":"2UPSPVIXHFHR3DOMOPKGSYXFAI","additional_properties":{},"type":"text","content":"Elixinol added that Vitable could add over A$5m of revenue, enabling the company to exceed A$20m in annual revenue. "},{"_id":"TDXCVI7IOZG3PMUU3Y3UE4JWPQ","additional_properties":{},"type":"text","content":"This is supported by Vitableâs recurring subscription revenue and direct consumer capability. "},{"_id":"J6UUMJLRCFAI3AEGUVTP6EDE4I","additional_properties":{},"type":"text","content":"The combined business is targeting A$27m in revenue and approximately A$3m of EBITDA by 2028. "},{"_id":"WCS54F2TQRGRZKPOF3LILTDLUE","additional_properties":{},"type":"text","content":"âVitable brings Elixinol an established subscription-based consumer platform, proprietary personalization capability and direct consumer relationships. These capabilities are highly complementary to our existing Australian health and wellness brands and create clear opportunities to grow customer value across the Group,â said Elixinol Wellnessâ CEO and Executive Director Natalie Butler.<b> </b>"},{"_id":"B6EBGIF6YBAYHMFNHCCSZSYLPA","additional_properties":{},"type":"text","content":"âHaving reset the business and sharpened our focus on Australia, this acquisition marks the next phase of Elixinolâs growth,â she added. âIt adds recurring revenue, a direct relationship with thousands of consumers and the ability to deliver increasingly personalised wellness offers.â"},{"level":2,"_id":"EIBIBKATTNHNJBEKVTJGAYTGDE","additional_properties":{},"type":"header","content":"Potential new services "},{"_id":"DALPQHZ7NNG7VDQGAUZRM5VSOQ","additional_properties":{},"type":"text","content":"Acquiring Vitable can also support cross-selling of Elixinolâs existing products to Vitableâs consumers and vice versa. 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2039plans-to-buy-personalized-nutrition-firm-vitable/"},{"content_elements":[{"_id":"4KKZDRQMTBF5JIFTVLY5INKBME","additional_properties":{},"type":"text","content":"Brands can no longer rely on a single approach; they need to understand different cultures, values and audience expectations, said Gillian Fish, business growth strategist and founder of The 6AM Agency, in a presentation on âBrand Trust in the Age of AI, Outrage and Infinite Noiseâ. "},{"_id":"AIPRONZKTVGD5DJU4TYZPIHVPA","additional_properties":{},"type":"text","content":"âGrowing insularity means that weâve got to rethink our business strategy,â she said. âIf you look at the evolution of the health information ecosystem over the last five years, now many young people feel that the average person can know as much as a doctor.â"},{"_id":"FYVQ6T3ZLNFV3ER6TTKJQWVOOQ","additional_properties":{},"type":"text","content":"As health information becomes more accessible, audiences are also more likely to scrutinize brandsâ claims, she said."},{"_id":"ORHOF7XT7RETRAESCDDSM77IFA","additional_properties":{},"type":"text","content":"Peers, family, scientists and online communities also influence purchasing decisions, making clear evidence and transparent communication increasingly important."},{"_id":"WOZS2SG76FCP3OKFDOZN2GNMKU","additional_properties":{},"type":"text","content":"âFor brands, the implication is clear: trust can no longer be assumed. It has to be deliberately earned, protected and sustained,â she said. "},{"level":2,"_id":"WNZ7332MT5CZVAF5VBN4UEVAEA","additional_properties":{},"type":"header","content":"AI is changing the health-information journey"},{"_id":"BWD5X7R6SFBBNM6TFE5SIKZV7Q","additional_properties":{},"type":"text","content":"Fish said the growing use of AI to access health information and receive immediate answers to general health questions is adding to this shift, noting that according to the 2026 <a href=\"https://www.edelman.com/sites/g/files/aatuss191/files/2026-04/2026%20Edelman%20Trust%20Barometer%20Special%20Report%20Trust%20and%20Health_Final.pdf\" target=\"_blank\" rel=\"\" title=\"https://www.edelman.com/sites/g/files/aatuss191/files/2026-04/2026%20Edelman%20Trust%20Barometer%20Special%20Report%20Trust%20and%20Health_Final.pdf\">Edelman Trust Barometer Global Report</a>, 81% of AI users will receive recommendations related to areas such as sleep, exercise and nutrition. "},{"_id":"P4K3OLX6LJA6VGFIWOUYR3B3IQ","additional_properties":{},"type":"text","content":"âWe know AI is playing a future role in search and discovery in many different ways,â she said."},{"_id":"7VBJ6WSOBNDGFETIYIJKVBX3OQ","additional_properties":{},"type":"text","content":"âOpenAI put out a statistic that 230 million people a week are asking health questions through its dedicated ChatGPT Health feature, so it simply cannot be ignored.â"},{"_id":"N5D3X6QDNNESXLBQARLCDTW36E","additional_properties":{},"type":"text","content":"On the other hand, only around 35% of people consult a GP for information on diet, nutrition, vitamins and minerals, while AI attracts a significantly higher level of engagement, Fish said."},{"level":2,"_id":"5BOOQCUKANCQLCTD4YE33P2HN4","additional_properties":{},"type":"header","content":"The trust gap"},{"_id":"KJMM5ULE7ZCFTNL3M2JJCNKFZU","additional_properties":{},"type":"text","content":"Fish highlighted a significant gap between executive perceptions and consumer reality, citing a <a href=\"https://www.pwc.com/us/en/library/trust-in-business-survey.html\" target=\"_blank\" rel=\"\" title=\"https://www.pwc.com/us/en/library/trust-in-business-survey.html\">PwC report</a> showing that 90% of business leaders believe people trust their companies and brands, compared with only 30% of consumers."},{"_id":"NJHO7L4G3VBUTLDL4G5DULM6ZU","additional_properties":{},"type":"text","content":"This makes trust a strategic business issue that belongs on the board and C-suite agenda, rather than being treated solely as a marketing responsibility."},{"_id":"IHLC2RUFUBFLFIAARMXJR5UPGA","additional_properties":{},"type":"text","content":"âForty-nine percent of consumers have started purchasing a brand or product from a company because of trust,â she said, citing <a href=\"https://business.adobe.com/uk/blog/the-latest/the-brands-putting-customer-trust-front-and-centre\" target=\"_blank\" rel=\"\" title=\"https://business.adobe.com/uk/blog/the-latest/the-brands-putting-customer-trust-front-and-centre\">recent data from Adobe</a>. "},{"_id":"J7JJEO4LNBHO5GM4RDQKBIEBHY","additional_properties":{},"type":"text","content":"Trust is also being threatened by misinformation, information overload and the growing influence of AI-generated authority, Fish said."},{"_id":"QI4ICIHJJ5AG3PRNWRQVA66JLQ","additional_properties":{},"type":"text","content":"âAnyone can be an expert. There is infinite noise, with every claim competing for attention,â she said. âSo consumers are starting to demand proof, not polish.â"}
2039,{"_id":"TI4WO6RZMRHCHLIMX7I6FWNVT4","additional_properties":{},"type":"text","content":"Evidence will therefore be central to building and maintaining trust, particularly in science and nutraceuticals, where withdrawn or retracted research can undermine credibility."},{"_id":"SFIS36OHDZA75PMBNODM3PG764","additional_properties":{},"type":"text","content":"âTrust is an asset and competitive advantage that attracts employees, investors and business opportunities,â she said."},{"_id":"MRASRENTWBAN3FJ7E4MA74LROY","additional_properties":{},"type":"text","content":"However, trust is not created through communications alone, but through a brand strategy that clearly defines what the organization stands for, who it serves, what matters to its audiences and what it will or will not do under pressure, Fish explained."},{"_id":"GEA5MVACBNAKFMMHBKLZFG3RRQ","additional_properties":{},"type":"text","content":"âTrust is born out of the strategy, not what you see communicated about that strategy,â she said."},{"_id":"4AP6OOVELJDUJKZJWNNQ73MTQU","additional_properties":{},"type":"text","content":"âNo amount of clever content, omnichannel execution or storytelling can compensate for a brand that has not really decided what it stands for.â"},{"level":2,"_id":"57BOUW2XCRH2XJ3R7PPBRDEZ3U","additional_properties":{},"type":"header","content":"Winning visibility in AI search"},{"_id":"GGFMF6NQ6ZD7BORACN3Y5RNLXI","additional_properties":{},"type":"text","content":"Fish noted that companies can apply several tactics for improving brand discoverability and trust, including third-party certification, collaboration with credible key opinion leaders, editorial coverage, published peer-reviewed evidence, and ensuring information online is consistent and easy for AI systems to access."},{"_id":"GZUYU4LI4NDIHMGJX45SEURM4Y","additional_properties":{},"type":"text","content":"She explained that a small number of influential websites provide a large share of the sources that AI systems use when generating answers, including platforms such as Reddit, Wikipedia, YouTube, LinkedIn and Forbes."},{"_id":"VZOBYCPA2ZHWTAXBOMRWQ5VHSY","additional_properties":{},"type":"text","content":"âReddit is increasingly important,â Fish said. âIf you look at the top 15 domains, they capture 68% of consolidated AI citation, with Reddit representing around 40% of multi-engine aggregate citations.â"},{"_id":"L2E3RPULEZETTDP6CMWAAGNV4Y","additional_properties":{},"type":"text","content":"Brands can be highly visible but poorly trusted, or highly trusted but difficult to find. For AI systems to find and understand a brand, its information must be credible enough for both systems and consumers to trust."},{"_id":"PQGPNCH3C5DSNPKDBQLXSKHVQM","additional_properties":{},"type":"text","content":"âTrustworthiness combined with discoverability is what makes an AI-ready brand,â she said, adding that in the age of AI, trust is about what can be verified. "},{"_id":"EEPQVKTN5VF47PWN4NL3ZIZZMM","additional_properties":{},"type":"text","content":"âThe companies that win will be the ones that can be checked â the ones that can stand up to scrutiny.â"},{"_id":"BRYWU4BOGZARVOKPRCYGYDRQCU","additional_properties":{},"type":"text","content":"Fish noted that to establish their validity, leadership teams can conduct audits to assess whether their brand strategy clearly defines what the organization stands for."},{"_id":"XTU5WBV42BCT3NMQW3VEWMFOVY","additional_properties":{},"type":"text","content":"âFor companies, this means asking: can we prove every claim we make? Do we have clear ownership of our AI systems and processes, and if not, what are we going to do about it? And is our story and narrative consistent across every channel and throughout the organization?â"}],"subheadlines":{"basic":"Consumer trust cannot be taken for granted as AI-generated information and increasingly informed audiences reshape how people assess brands and health claims, delegates heard at Vitafoods Asia in Bangkok."},"description":{"basic":"Brands must rethink brand trust as AI, misinformation, cultural shifts and changing health-information habits reshape how consumers evaluate health and nutrition products. Experts say evidence, transparency, credibility, AI search visibility and third-party validation will be essential for nutrition brands seeking to build trust and remain discoverable in the age of AI. 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2039,"created_date":"2026-09-09T18:59:41.435Z","publish_date":"2026-09-23T02:27:42.465Z","_id":"UQDLCJPWTVEZPFOFBUMBUHREO4","website":"nutraingredients-v2","website_url":"/Article/2026/09/23/lifestream-sees-vision-brain-dual-care-as-key-innovation-driver-for-eye-supplements/"}],"additional_properties":{"took":40,"timed_out":false},"count":10000,"next":4,"_id":"8272ab20ed97a67afc08632b87367d4a6cef18b67aa9e870b2a11eb2970430e7"},"expires":1790270434510,"lastModified":1790270134334},"{\"feedSize\":4,\"includeSections\":\"/News/Suppliers\",\"includeSubtypes\":\"news_text,news_video,news_audio,news_gallery,news_slider\"}":{"data":{"type":"results","version":"0.6.0","content_elements":[{"content_elements":[{"_id":"UYCJPTUCQRCJNOOR4HSEY2W5WY","additional_properties":{},"type":"text","content":"The study, funded by Spainâs Ministry of Science, sought to characterize the phenolic content of the by-products, extract the main phenolic compounds using industrial processes, and evaluate the antioxidant capacity of the resulting extracts."},{"_id":"GB3FBGF7ANA7RBSTVEPNYWAXOQ","additional_properties":{},"type":"text","content":"âThese effluents are ideal sources for obtaining antioxidant phenolic extracts for use in the food, cosmetics and nutraceutical industries, thereby improving the formulation of new functional foods and enabling the replacement of synthetic antioxidants,â the researchers wrote in the journal <i>Foods</i>."},{"level":2,"_id":"VLDV7POKONF5VKEBHIBW2FGFJA","additional_properties":{},"type":"header","content":"Spain explores new uses for olive by-products"},{"_id":"S2OJ7ICZYJEHNMUWZJS6DBJSFU","additional_properties":{},"type":"text","content":"Accounting for <a href=\"https://www.internationaloliveoil.org/wp-content/uploads/2023/12/IOC-Table-Olive-Dashboard.html\" target=\"_blank\" rel=\"\">45% of the global production of olive oil</a>
2039 and as the second largest producer of table olives, Spain generates large quantities of by-products such as alperujo (a mix of olive pulp, skin, stone fragments and vegetation water) and brine."},{"_id":"JNOSIEFNQ5E6JI2OKSBKVAHPGI","additional_properties":{},"type":"text","content":"âThe olive industry is experiencing significant growth, which is only held back by the environmental and management issues that its by-products can cause,â the researchers noted. âThe two most polluting effluents produced are a new aqueous phase, or âalpechÃn â, obtained from alperujo, which is the most important waste generated in the olive oil industry, and brine in the table olive industry.â"},{"_id":"IZ24STTYIRGGVD6XDNIVQCAX6M","additional_properties":{},"type":"text","content":"The high organic and phytotoxic loads of both by-products and the conductivity of the brines make their reuse difficult and pose a real technological challenge owing to the environmental problems they cause, the researchers explained. "},{"_id":"IJIV56OOLRGLVLBRORCXDTMI2Y","additional_properties":{},"type":"text","content":"These by-products also contain valuable bioactive compounds, particularly hydroxytyrosol (HT), tyrosol (Ty) and DHPG, that exhibit antioxidant activity and <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6571782/\" target=\"_blank\" rel=\"\" title=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6571782/\">have shown promise</a> as anti-inflammatory ingredients for cardiovascular, skin health and healthy aging product applications."},{"level":2,"_id":"REFR2ZCTGZBERLLRBH74SUSH2U","additional_properties":{},"type":"header","content":"A new source of natural antioxidants"},{"_id":"ZXTTCW7THNDXRI4TBTKM2RK4KA","additional_properties":{},"type":"text","content":"The researchers investigated three olive industry by-products: table olive brine, alperujo, and the new liquid alpechin fraction. "},{"_id":"AKEOSJOMTFCPPBMPQ4BFJI45W4","additional_properties":{},"type":"text","content":"They extracted phenolic compounds from the liquid by-products using ion-exchange chromatographic columnsâwhich act like a filter that traps the useful phenolic compounds while allowing other substances to pass throughâand analyzed the resulting extracts and treated effluents to determine their phenolic composition and potential for further use."},{"_id":"CNAWID3FDBGGDBGE5YWPBO77JE","additional_properties":{},"type":"text","content":"The researchers measured the phenolic compounds, sugars, pH and conductivity in the olive by-products. They then used multiple tests to determine how strong the antioxidant properties of the olive by-product extracts were."},{"_id":"2I2Q3J4RNVE7DE57ZZM3D67QSQ","additional_properties":{},"type":"text","content":"The chromatographic system successfully removed phenolic compounds from both alpechin and brine while producing concentrated phenolic extracts. "},{"_id":"N5L7E2WPOZA7BFHOKXUZZN5BF4","additional_properties":{},"type":"text","content":"In alpechin, the treatment reduced total phenolics by about 64%, making this olive-industry waste less environmentally problematic, while the main compoundsâHT, DHPG and Tyâdecreased by 82%, 63% and 70%, respectively."},{"_id":"QIO5HNIVAZDBDKACTW3TJ3DZOM","additional_properties":{},"type":"text","content":"The treatment also reduced phenolic compounds in brine. Two passes through the chromatographic column removed approximately 60% of the total phenolics, with HT and Ty decreasing by 88% and 84%, respectively."},{"_id":"6GXJ5DLEB5H5VFY3TSLZRXQTKE","additional_properties":{},"type":"text","content":"The alpechin extract showed stronger antioxidant activity than the brine extract, despite the brine extract containing more total phenolics. This result suggests that specific compounds, particularly HT and DHPG, contributed strongly to antioxidant activity, the researchers noted."},{"_id":"ONPRBE2AXVFN5K63KTVAE3BNLY","additional_properties":{},"type":"text","content":"âThe antioxidant activity data indicate that the extracts obtained have high potential, with HT being the main component,â the researchers wrote. âCompared with other extracts of the same nature, including olive oil by-products and table ol
2039ives, twice the scavenging activity was observed for the three free radicals studied, and twice the reducing power of these extracts.â"},{"_id":"TEIBAFF2ABADXPOHA5BHNKRGPE","additional_properties":{},"type":"text","content":"Overall, the chromatographic process reduced the harmful phenolic content of the waste liquids and recovered valuable phenolic extracts with strong antioxidant properties."},{"_id":"6VV4VZWMUNGRTJN7UNPWVY6JL4","additional_properties":{},"type":"text","content":"âThis demonstrates that the use of industrial technologies enables the production of extracts with high antioxidant activity for use in the food, cosmetics and nutraceutical industries, among others, which will add value to the system by not only allowing for the detoxification of by-products but also providing an additional benefit to the value chain,â the researchers concluded. 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2039we communicate it, should reflect that,â Heather Woolery-Lloyd, MD, FAAD, board-certified dermatologist and chief medical advisor at Nutrafol and speaker at the upcoming symposium, told NI. "},{"_id":"5XZCZEDNJJENFAD5TMWFWCE7V4","additional_properties":{},"type":"text","content":"Dr. Woolery-Lloyd pointed to hair health as an example. Hormones, stress, nutrition, aging and lifestyle can all play a role, making evidence on a popular individual ingredient less informative than research demonstrating that a specific formulation improved a defined outcome in its intended population."},{"level":2,"_id":"LFJCL5KQBJARTLN5HJ4PN4KNKY","additional_properties":{},"type":"header","content":"What does âclinically studiedâ mean?"},{"_id":"WKQGMLRFIBEXBFJOJB7TZUJIMI","additional_properties":{},"type":"text","content":"Ryan Woodbury, co-founder and co-CEO of maternal nutrition company Needed, raised a similar concern around the way evidence is communicated."},{"_id":"UKJMSBBYN5GOBOHGXFSSMFQ3HM","additional_properties":{},"type":"text","content":"Growing investment in womenâs health has helped bring research and product innovation to previously overlooked areas, she said, but terms such as âclinically studiedâ and âclinically provenâ can obscure important distinctions."},{"_id":"BCXZDTE2XZHDXITF5VNISLETAA","additional_properties":{},"type":"text","content":"âSometimes only one ingredient was studied, rather than the finished product, or it was tested at a different dose, in a different population or for a different outcome than the product claims,â Woodbury told NI. "},{"_id":"YZNZQXRE25F43FEM5DCTVOSOOI","additional_properties":{},"type":"text","content":"For companies, that creates a communications challenge alongside the scientific one."},{"_id":"7KQUNPHDBJEGHLEEG2UYVZ2VYE","additional_properties":{},"type":"text","content":"âWe have learned that our job is to make the truth compelling...we can simplify the language without changing the evidence by remaining clear about who was studied, what was measured and how certain the conclusion is,â she added. "},{"level":2,"_id":"E5R2WE4POBDVVF4RLBRX4EFBLE","additional_properties":{},"type":"header","content":"Closing the distance between science and consumers"},{"_id":"F476NKRZGVEX7HM5ATA4PTKM5E","additional_properties":{},"type":"text","content":"SciComms Connect grew out of CRNâs previously separate Science in Session and WellComms programs. Ventura said CRN noticed attendees moving between the scientific and communications sessions when the programs were held side by side, pointing to a need for more interaction between the disciplines."},{"_id":"AZWAFIQ25RCETMRCCTRDGJFGV4","additional_properties":{},"type":"text","content":"The resulting symposium is intended to serve as what he called the âconnective tissueâ between the science itself and how it is ultimately communicated to consumers."},{"_id":"VUEQITTYAZF3LHQXRXIAJXS34E","additional_properties":{},"type":"text","content":"That connection has become more complicated as consumers increasingly turn to social media, influencers and artificial intelligence for health information, according to Ventura."},{"_id":"KAWK76BPABHHBARTTQSBW3OM7A","additional_properties":{},"type":"text","content":"âI think SciComms Connect ultimately is [â¦] figuring out how to sort of shorten the distance between the laboratory and the women who are trying to make decisions about their health,â he said."},{"_id":"ZIYUCENZURBNLAJZGMN56Q5CA4","additional_properties":{},"type":"text","content":"Wong said that work also needs to begin earlier within companies. Rather than handing a finished innovation to communications teams after formulation and legal and regulatory work are complete, she said scientific, regulatory, innovation and communications functions should work together throughout the process."},{"_id":"B5BYZLS7XBDQZFDSK6Y2RRFXEQ","additional_properties":{},"type":"text","content":"And despite the growing attention to womenâs health, significant scientific gaps remain."},{"_id":"HNJNZ4XAZZBIFMH6JRASGFACHY","additional_properties":{},"type":"text","content":"Wong pointed particularly to nutrition during the perimenopause and menopause transition and maternal health, including support for women during pregnancy and postpartum."},{"_id":"COFM2VQTYJHQBJ5LH4MHN3H6RQ","additional_properties":{},"type":"text","content":"âWeâre just at the tip of the iceberg in terms of all the hormonal shifts that are happening during the perimenopause, menopause transition,â she said. "},{"_id":"ILR5D3LQQJDUDDCCBOE33QN5EM","additional_properties":{},"type":"text","content":"âWeâre starting to understand a little bit more, but I think thereâs just so much.â"},{"_id":"OUPNL5RUPBAL7P7AILGKKJHNBI","additional_properties":{},"type":"text","content":"<i>For more information and to register, please click </i><a href=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\" target=\"_blank\" rel=\"\" title=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\"><i>here</i></a><i>. </i>"}],"subheadlines":{"basic":"CRNâs upcoming SciComms Connect symposium will highlight how womenâs health is attracting more research, investment, and product development, but translating that momentum into credible supplement products and consumer messaging remains challenging."},"description":{"basic":"The Council for Responsible Nutritionâs inaugural SciComms Connect symposium will address the challenges of translating growing research and investment in womenâs health into credible supplement products and consumer messaging. 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2039,{"level":2,"_id":"QWSQC4MMFFF3VDGDG3QJZG2TLI","additional_properties":{},"type":"header","content":"Popular in Korea"},{"_id":"7UGUF3FY5NGE3AY3JOFW25FMRI","additional_properties":{},"type":"text","content":"DracoBelle is a water-soluble powder extract from organically grown Moldavian Dragonhead. It boosts collagen production in skin tissues by activating the anti-aging and longevity intrinsic pathway of AMPK/ FOXO, which is known to directly support the build-up of extracellular matrix."},{"_id":"QWRKUYQTG5GRTEKEYQ6LW5XXI4","additional_properties":{},"type":"text","content":"Studies have shown that it can increase the skinâs hydration, elasticity and density. A study <a href=\"https://www.nutraingredients.com/Article/2025/04/10/moldavian-dragonhead-extract-reduces-key-aging-skin-markers/\" target=\"_blank\" rel=\"\">published in 2025</a>, involving more than 100 female participants, showed that daily intake of 100mg of DracoBelle significantly increased skin thickness, particularly dermal density, along with continuous improvements in hydration compared to placebo."},{"_id":"6M7PZD7EZZCCVAW2CDTAJRLFOY","additional_properties":{},"type":"text","content":"Another well-performing ingredient in the Korean market is MintyBright, an extract derived from dried apple mint leaves. 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study, funded by Spainâs Ministry of Science, sought to characterize the phenolic content of the by-products, extract the main phenolic compounds using industrial processes, and evaluate the antioxidant capacity of the resulting extracts."},{"_id":"GB3FBGF7ANA7RBSTVEPNYWAXOQ","additional_properties":{},"type":"text","content":"âThese effluents are ideal sources for obtaining antioxidant phenolic extracts for use in the food, cosmetics and nutraceutical industries, thereby improving the formulation of new functional foods and enabling the replacement of synthetic antioxidants,â the researchers wrote in the journal
2039<i>Foods</i>."},{"level":2,"_id":"VLDV7POKONF5VKEBHIBW2FGFJA","additional_properties":{},"type":"header","content":"Spain explores new uses for olive by-products"},{"_id":"S2OJ7ICZYJEHNMUWZJS6DBJSFU","additional_properties":{},"type":"text","content":"Accounting for <a href=\"https://www.internationaloliveoil.org/wp-content/uploads/2023/12/IOC-Table-Olive-Dashboard.html\" target=\"_blank\" rel=\"\">45% of the global production of olive oil</a> and as the second largest producer of table olives, Spain generates large quantities of by-products such as alperujo (a mix of olive pulp, skin, stone fragments and vegetation water) and brine."},{"_id":"JNOSIEFNQ5E6JI2OKSBKVAHPGI","additional_properties":{},"type":"text","content":"âThe olive industry is experiencing significant growth, which is only held back by the environmental and management issues that its by-products can cause,â the researchers noted. âThe two most polluting effluents produced are a new aqueous phase, or âalpechÃn â, obtained from alperujo, which is the most important waste generated in the olive oil industry, and brine in the table olive industry.â"},{"_id":"IZ24STTYIRGGVD6XDNIVQCAX6M","additional_properties":{},"type":"text","content":"The high organic and phytotoxic loads of both by-products and the conductivity of the brines make their reuse difficult and pose a real technological challenge owing to the environmental problems they cause, the researchers explained. "},{"_id":"IJIV56OOLRGLVLBRORCXDTMI2Y","additional_properties":{},"type":"text","content":"These by-products also contain valuable bioactive compounds, particularly hydroxytyrosol (HT), tyrosol (Ty) and DHPG, that exhibit antioxidant activity and <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6571782/\" target=\"_blank\" rel=\"\" title=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6571782/\">have shown promise</a> as anti-inflammatory ingredients for cardiovascular, skin health and healthy aging product applications."},{"level":2,"_id":"REFR2ZCTGZBERLLRBH74SUSH2U","additional_properties":{},"type":"header","content":"A new source of natural antioxidants"},{"_id":"ZXTTCW7THNDXRI4TBTKM2RK4KA","additional_properties":{},"type":"text","content":"The researchers investigated three olive industry by-products: table olive brine, alperujo, and the new liquid alpechin fraction. "},{"_id":"AKEOSJOMTFCPPBMPQ4BFJI45W4","additional_properties":{},"type":"text","content":"They extracted phenolic compounds from the liquid by-products using ion-exchange chromatographic columnsâwhich act like a filter that traps the useful phenolic compounds while allowing other substances to pass throughâand analyzed the resulting extracts and treated effluents to determine their phenolic composition and potential for further use."},{"_id":"CNAWID3FDBGGDBGE5YWPBO77JE","additional_properties":{},"type":"text","content":"The researchers measured the phenolic compounds, sugars, pH and conductivity in the olive by-products. They then used multiple tests to determine how strong the antioxidant properties of the olive by-product extracts were."},{"_id":"2I2Q3J4RNVE7DE57ZZM3D67QSQ","additional_properties":{},"type":"text","content":"The chromatographic system successfully removed phenolic compounds from both alpechin and brine while producing concentrated phenolic extracts. "},{"_id":"N5L7E2WPOZA7BFHOKXUZZN5BF4","additional_properties":{},"type":"text","content":"In alpechin, the treatment reduced total phenolics by about 64%, making this olive-industry waste less environmentally problematic, while the main compoundsâHT, DHPG and Tyâdecreased by 82%, 63% and 70%, respectively."},{"_id":"QIO5HNIVAZDBDKACTW3TJ3DZOM","additional_properties":{},"type":"text","content":"The treatment also reduced phenolic compounds in brine. Two passes through the chromatographic column removed approximately 60% of the total phenolics, with HT and Ty decreasing by 88% and 84%, respectively."},{"_id":"6GXJ5DLEB5H5VFY3TSLZRXQTKE","additional_properties":{},"type":"text","content":"The alpechin extract showed stronger antioxidant activity than the brine extract, despite the brine extract containing more total phenolics. This result suggests that specific compounds, particularly HT and DHPG, contributed strongly to antioxidant activity, the researchers noted."},{"_id":"ONPRBE2AXVFN5K63KTVAE3BNLY","additional_properties":{},"type":"text","content":"âThe antioxidant activity data indicate that the extracts obtained have high potential, with HT being the main component,â the researchers wrote. âCompared with other extracts of the same nature, including olive oil by-products and table ol
2039ives, twice the scavenging activity was observed for the three free radicals studied, and twice the reducing power of these extracts.â"},{"_id":"TEIBAFF2ABADXPOHA5BHNKRGPE","additional_properties":{},"type":"text","content":"Overall, the chromatographic process reduced the harmful phenolic content of the waste liquids and recovered valuable phenolic extracts with strong antioxidant properties."},{"_id":"6VV4VZWMUNGRTJN7UNPWVY6JL4","additional_properties":{},"type":"text","content":"âThis demonstrates that the use of industrial technologies enables the production of extracts with high antioxidant activity for use in the food, cosmetics and nutraceutical industries, among others, which will add value to the system by not only allowing for the detoxification of by-products but also providing an additional benefit to the value chain,â the researchers concluded. "},{"_id":"75JW6FDAGZCRDJLYPMEBSBEWHA","type":"divider"},{"_id":"EDF3WKL35RHI5FNMLRD4YRDZKA","additional_properties":{},"type":"text","content":"Source: <i>Foods;</i> doi: <a href=\"https://doi.org/10.3390/foods15193370\" target=\"_blank\" rel=\"\">https://doi.org/10.3390/foods15193370</a>; âExtraction of Antioxidant Phenolic Extracts from the Two Main Liquid Effluents of the Olive Industry.â Authors: Fernández Prior, et al. "}],"subheadlines":{"basic":"Olive waste could be utilized as a source of natural antioxidants in functional foods and nutraceuticals, according to researchers who recovered valuable compounds from olive brine and alpechin."},"description":{"basic":"Researchers in Spain found that olive industry by-products, including olive brine and alpechin, can be used to recover phenolic compounds with strong antioxidant activity. 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2039sports performance attract attention. The central question, however, is how nitrate produces these effects. The proposed mechanism involves a series of reduction steps: Nitrate is converted to nitrite, and nitrite is then converted to nitric oxide."},{"_id":"OYIDVDKRYRFAXOFBXRBSGQIBII","additional_properties":{},"type":"text","content":"Nitric oxide has been the focus of intense research since scientists discovered that it is generated from the amino acid L-arginine through three distinct enzymes known as nitric oxide synthases. That work helped lead to the <a href=\"https://www.nobelprize.org/prizes/medicine/1998/summary/\" target=\"_blank\" rel=\"\">1998 Nobel Prize in Physiology or Medicine</a> for the discovery that nitric oxide acts as a signaling molecule in the cardiovascular system. Long before the beet-juice debate, nitric oxide-delivering drugs were known to lower blood pressure because of their vasodilator properties. They do this by activating guanylate cyclase and elevating cGMP. It was not until the 1980s, however, that our research identified a lack of nitric oxide as a key driver of high blood pressure <a href=\"https://www.ahajournals.org/doi/10.1161/01.HYP.10.2.164\" target=\"_blank\" rel=\"\">endothelial nitric oxide and hypertension</a>."},{"_id":"Z3TFL5AEGBCETG5OF2ILQU2W4I","additional_properties":{},"type":"text","content":"That history makes enthusiasm for natural ways to raise vascular nitric oxide understandable. The problem is that the nitrate-nitrite-nitric oxide pathway operates independently of nitric oxide synthase, and its effects appear to be highly context-dependent."},{"_id":"WE3P6DBO5FDPTAJP5MZB7BHMYY","additional_properties":{},"type":"text","content":"The initial conversion of nitrate to nitrite is driven by nitrate reductase enzymes in specific bacteria in saliva. The next stepâthe conversion of nitrite to nitric oxideâcan occur under acidic conditions or through hypoxia-induced activation of xanthine oxidase. Those conditions are most likely to occur locally, in hard-working muscle, not systemically throughout the circulation."},{"_id":"5LNIBRIFE5G63EC7B6NVGV7XXE","additional_properties":{},"type":"text","content":"In extreme aerobic exercise, such as competitive cycling or marathon running, working muscles can create the low pH and relative ischemia needed to convert nitrite to nitric oxide. The likely result is a localized increase in blood flow that helps deliver oxygen and nutrients while removing metabolic byproducts such as lactic acid."},{"_id":"2E3SJ6X4EJABDL4REANFYGVKHA","additional_properties":{},"type":"text","content":"My research team tested whether this scenario was limited to aerobic exercise. <a href=\"https://doi.org/10.1080/07315724.2015.1081572\" target=\"_blank\" rel=\"\">In a strength-training study</a>, a bar product combining beets with antioxidants improved performance and muscle recruitment. Importantly, however, these benefits occurred without changes in blood pressure."},{"_id":"W7EBWCOEP5CQHNAKPYPO3X3TSE","additional_properties":{},"type":"text","content":"The lesson is that hard-working muscles can tap the nitrogen cycle to generate nitric oxide locally, but that does not mean beets produce a meaningful systemic effect on blood pressure. In the presence of hemoglobin, nitric oxide <a href=\"https://doi.org/10.1074/jbc.273.30.18709\" target=\"_blank\" rel=\"\">has a half-life of milliseconds before it is rapidly oxidized back to nitrate.</a> The effect is localized and mild, not body wide and sustained."},{"_id":"NJLYMW2UXZFFRJ2BKVWTYVVS7A","additional_properties":{},"type":"text","content":"That distinction matters. Some aerobic exercise studies show small reductions in systolic blood pressure, often around 2 to 4 mmHg, while others show no effect. <a href=\"https://doi.org/10.1016/j.numecd.2024.06.009\" target=\"_blank\" rel=\"\">A large meta-analysis of beet or beet-juice interventions</a> found a small effect on systolic blood pressure, but no effect on diastolic pressure, mean arterial pressure or 24-hour blood pressure measurements. The authors concluded: âThere is no evidence for a prolonged 24-h BP-reducing effect. Certainty of evidence is low.â"},{"_id":"L4Z5O2ZEOJBOJH7R7YCM725A74","additional_properties":{},"type":"text","content":"For sports performance, the nitrate story has value. For hypertension, it is often taken out of context."},{"level":2,"_id":"WPDNMO26FRHLZPUD7QR2CD2ZHM","additional_properties":{},"type":"header","content":"Nitric oxide and the circulation"},{"_id":"6KW5YUQMMFA5ZDIOZ6I7QJNJBU","additional_properties":{},"type":"text","content":"Beyond the issues with the accuracy of measuring blood pressure (systolic, diastolic and mean) we need to better place perspective on how nitric oxide works and where? Nitric oxide production in blood vessels has a half-life of a few milliseconds, as <a href=\"https://www.jbc.org/article/S0021-9258(18)80192-2/fulltext\" target=\"_blank\" rel=\"\" title=\"https://www.jbc.org/article/S0021-9258(18)80192-2/fulltext\">my team defined with a unique electrochemical probe</a>. Basically, all nitric oxide actions are local, and when it interacts with hemoglobin it is rapidly oxidized to nitrate and other reactive nitrogen species before it can circulate like a hormone. The furthest it can reach from sites of production is a few cells, certainly not like a circulating hormone. "},{"_id":"ATII6CHS7BFWHOJNA4UYST3XQI","additional_properties":{},"type":"text","content":"For increased nitric oxide production to lower blood pressure, one needs a substantially greater production of nitric oxide and it needs to be systemic, i.e., throughout the body and not just a working muscle. There can be a role for nitric oxide in controlling vascular resistance but also in septic shock. In the latter, excessive production of nitric oxide, activated by bacterial infections, greatly reduces vascular tone and limits organ perfusion as a result of the substantially reduced blood pressure. <a href=\"https://pubmed.ncbi.nlm.nih.gov/7714773/\" target=\"_blank\" rel=\"\">My research team showed</a> that capturing excess NO with vitamin B12 (via its bonding with the cobalt atom) could sequester excess nitric oxide and limit organ failure and mortality in sepsis. "},{"_id":"FE3NZY2EXJF45J4LELPRMDAISM","additional_properties":{},"type":"text","content":"From this it is clear that nitric oxide plays an important role in circulatory function, as seen with examples of excess and inadequacy."},{"level":2,"_id":"DRZPY5ABNZFEHIXGLU4MZMQ2HY","additional_properties":{},"type":"header","content":"Vascular resistance and systolic vs. diastolic blood pressure"},{"_id":"U5NF3RXBQRGILIKPNP3WGURVGI","additional_properties":{},"type":"text","content":"The other concept that needs to be accounted for, is that as a vasodilator, nitric oxide would primarily influence blood pressure by lowering vascular resistance, as opposed to cardiac output. "},{"_id":"VXBY5F6WK5HJNF5GUUSQAFTMYQ","additional_properties":{},"type":"text","content":"When we measure diastolic blood pressure, we are getting a window into the arterial resistance of the cardiovascular system because it is independent of the heart contractions. Conversely, systolic blood pressure reflects when the heart contracts and that impact is layered on top of overall systemic vascular resistance. "},{"_id":"ACJ6X6YCBJBYDM2CMFJ6CVI7EA","additional_properties":{},"type":"text","content":"When an intervention, like beets, does not alter diastolic (or mean) arterial pressure then there one can safely assume that vascular resistance is not altered. In other words, there is no evidence that ingestion of nitrate rich beets promotes systemic vasodilation. "},{"_id":"37SXUKRUKBFCBJWAGWOTS35VYU","additional_properties":{},"type":"text","content":"If nitric oxide was being produced systemically in amounts that cause widespread vasodilation, then diastolic blood pressure would fall. It doesnât in any of these studies with beets. "},{"level":2,"_id":"A7OWQZBC35GAFLOPCZFXQZKWZQ","additional_properties":{},"type":"header","content":"Food vs. supplements vs. drugs"},{"_id":"GQ27CIOSANE47HWCGSOTO7C7ZA","additional_properties":{},"type":"text","content":"Inherent in the rampant publicity that is associated with beets and blood pressure is the robust enthusiasm to manage a pervasive and critical healthcare issue, hypertension, with dietary driven solutions. "},{"_id":"V7WXLNNVXVBCHKVAAP4W7DYYRI","additional_properties":{},"type":"text","content":"Here there is a passionate abhorrence to using supplements and pharmaceuticals, after all âFood is they Medicineâ. Directed by that passion and amplified by a lack of understanding of the complexities of the biochemistry of nitric oxide and related nitrogen oxides, the impact of this combination is that a false narrative is generated and spread profusely. "},{"_id":"EAW4OB6RABHS5P3VQZO6UVV2IU","additional_properties":{},"type":"text","content":"Historical perspectives are tossed aside as being too confusing. Information like the vasodilators nitroprusside and nitroglycerin, the Nobel Prize for those actions and the nitric oxide generation from L-arginine, and the massive amount of research on nitric oxide in general, are not included as they are not food generated."},{"_id":"HPWUT4DUGVGZBJHDKIA67DNULY","type":"divider"},{"_id":"HZX6OHD7D5B4RFWDCQOUUJADXU","additional_properties":{},"type":"text","content":"<i>Dr. Mark JS Miller has extensive experience in entrepreneurship, M&A, manufacturing, R&D, marketing and brand building within the natural products industry. Prior to that transition he was a tenured professor of pharmacology, pediatrics and cardiovascular edicine in three different US-based medical schools. </i>"},{"_id":"VQ3A4RHGPVE4JBMM7CSP4XJE34","additional_properties":{},"type":"text","content":"<i>His contributions to our understanding of nitric oxide and related reactive nitrogen species has defined health and disease across a wide range of disciplines and systems. They include cardiovascular function, inflammation, gastroenterology, cancer, fetal development, neonatal nutrition, sports performance and biochemistry. </i>"}],"subheadlines":{"basic":"An increasingly common mainstream media narrative portrays beets as an effective approach to lowering high blood pressure, but this claim remains unsubstantiated and reflects a misguided understanding of the cardiovascular system and the role of nitric oxide."},"description":{"basic":""},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Research","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Research","description":"","_id":"/News/Research","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News","weekly-newsletter-sections":"/"},"website":"nutraingredients-v2","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"navigation":{"nav_title":"Research","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Research"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Research","_id":"/News/Research","ancestors":{"weekly-newsletter-sections":["/"]},"order":{"default":3,"main-navigation":3,"weekly-newsletter-sections":1001}}},"_website_section_id":"nutraingredients-v2./News/Research","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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Was the finished formulation tested, or only an individual ingredient? And how can companies communicate promising research without getting ahead of the evidence?</i>"},{"_id":"JI5O46RTZJEKLO5ARS354TH7LY","additional_properties":{},"type":"text","content":"Those questions are at the center of the Council for Responsible Nutritionâs inaugural SciComms Connect symposium, which will bring scientific, product development and communications professionals together Oct. 6 in Carlsbad, California. The program, themed âBridging Science and Marketing to Advance Womenâs Vitality,â is part of CRNâs Signature Events and precedes Innovation Exchange and CONVERGENCE â26."},{"_id":"AXUTB5JCSRDDNHDVRIA54FEJOE","additional_properties":{},"type":"text","content":"Andrea Wong, Ph.D., senior vice president and chief science officer at CRN, said increased attention to womenâs health comes as consumers navigate an increasingly crowded information environment."},{"_id":"OY4IFQDHX5FJRF7J6NIFYQG2VM","additional_properties":{},"type":"text","content":"âFinally, womenâs health is getting the attention it deserves in terms of the scientific researchâ being conducted by academia and industry, she told NutraIngredients."},{"_id":"A2TXKRO6DRH4HOZCGXVQNKU24Q","additional_properties":{},"type":"text","content":"At the same time, she said, women are encountering overhyped messaging around everything from menopause to other health concerns."},{"_id":"LO6Z7GKSSJDGPMB25SEJGIHHQI","additional_properties":{},"type":"text","content":"âWe want to give our audience really practical tools for them to navigate this area, to look at the research,â Wong said. âWhat does it actually say? Donât overhype it, but donât undersell it either.â"},{"level":2,"_id":"BT2H74OKD5CIFJ2TPTQFWTP47M","additional_properties":{},"type":"header","content":"Women are not one consumer"},{"_id":"HFB5KFRWIVDRNGANC54NZESU74","additional_properties":{},"type":"text","content":"CRN built the SciComms Connect agenda around several areas of womenâs health, including menopause and healthy aging, active nutrition and maternal health."},{"_id":"O42D3S6GARDNZHUZZHWFSZ47MU","additional_properties":{},"type":"text","content":"Jeff Ventura, vice president of communications at CRN, said one potential trap is treating womenâs health as a catch-all category despite differences across adolescence, reproductive years, pregnancy, postpartum, menopause and healthy aging."},{"_id":"76TAIBZIUNFR5OWUKTFB5QHHPQ","additional_properties":{},"type":"text","content":"That distinction matters when companies decide not only what to formulate but what evidence can reasonably support their products."},{"_id":"U67OWBXAMBD47GSHLIJTNJW2WY","additional_properties":{},"type":"text","content":"âWomen are not one homogeneous group, and the science, and the way
2039we communicate it, should reflect that,â Heather Woolery-Lloyd, MD, FAAD, board-certified dermatologist and chief medical advisor at Nutrafol and speaker at the upcoming symposium, told NI. "},{"_id":"5XZCZEDNJJENFAD5TMWFWCE7V4","additional_properties":{},"type":"text","content":"Dr. Woolery-Lloyd pointed to hair health as an example. Hormones, stress, nutrition, aging and lifestyle can all play a role, making evidence on a popular individual ingredient less informative than research demonstrating that a specific formulation improved a defined outcome in its intended population."},{"level":2,"_id":"LFJCL5KQBJARTLN5HJ4PN4KNKY","additional_properties":{},"type":"header","content":"What does âclinically studiedâ mean?"},{"_id":"WKQGMLRFIBEXBFJOJB7TZUJIMI","additional_properties":{},"type":"text","content":"Ryan Woodbury, co-founder and co-CEO of maternal nutrition company Needed, raised a similar concern around the way evidence is communicated."},{"_id":"UKJMSBBYN5GOBOHGXFSSMFQ3HM","additional_properties":{},"type":"text","content":"Growing investment in womenâs health has helped bring research and product innovation to previously overlooked areas, she said, but terms such as âclinically studiedâ and âclinically provenâ can obscure important distinctions."},{"_id":"BCXZDTE2XZHDXITF5VNISLETAA","additional_properties":{},"type":"text","content":"âSometimes only one ingredient was studied, rather than the finished product, or it was tested at a different dose, in a different population or for a different outcome than the product claims,â Woodbury told NI. "},{"_id":"YZNZQXRE25F43FEM5DCTVOSOOI","additional_properties":{},"type":"text","content":"For companies, that creates a communications challenge alongside the scientific one."},{"_id":"7KQUNPHDBJEGHLEEG2UYVZ2VYE","additional_properties":{},"type":"text","content":"âWe have learned that our job is to make the truth compelling...we can simplify the language without changing the evidence by remaining clear about who was studied, what was measured and how certain the conclusion is,â she added. "},{"level":2,"_id":"E5R2WE4POBDVVF4RLBRX4EFBLE","additional_properties":{},"type":"header","content":"Closing the distance between science and consumers"},{"_id":"F476NKRZGVEX7HM5ATA4PTKM5E","additional_properties":{},"type":"text","content":"SciComms Connect grew out of CRNâs previously separate Science in Session and WellComms programs. Ventura said CRN noticed attendees moving between the scientific and communications sessions when the programs were held side by side, pointing to a need for more interaction between the disciplines."},{"_id":"AZWAFIQ25RCETMRCCTRDGJFGV4","additional_properties":{},"type":"text","content":"The resulting symposium is intended to serve as what he called the âconnective tissueâ between the science itself and how it is ultimately communicated to consumers."},{"_id":"VUEQITTYAZF3LHQXRXIAJXS34E","additional_properties":{},"type":"text","content":"That connection has become more complicated as consumers increasingly turn to social media, influencers and artificial intelligence for health information, according to Ventura."},{"_id":"KAWK76BPABHHBARTTQSBW3OM7A","additional_properties":{},"type":"text","content":"âI think SciComms Connect ultimately is [â¦] figuring out how to sort of shorten the distance between the laboratory and the women who are trying to make decisions about their health,â he said."},{"_id":"ZIYUCENZURBNLAJZGMN56Q5CA4","additional_properties":{},"type":"text","content":"Wong said that work also needs to begin earlier within companies. Rather than handing a finished innovation to communications teams after formulation and legal and regulatory work are complete, she said scientific, regulatory, innovation and communications functions should work together throughout the process."},{"_id":"B5BYZLS7XBDQZFDSK6Y2RRFXEQ","additional_properties":{},"type":"text","content":"And despite the growing attention to womenâs health, significant scientific gaps remain."},{"_id":"HNJNZ4XAZZBIFMH6JRASGFACHY","additional_properties":{},"type":"text","content":"Wong pointed particularly to nutrition during the perimenopause and menopause transition and maternal health, including support for women during pregnancy and postpartum."},{"_id":"COFM2VQTYJHQBJ5LH4MHN3H6RQ","additional_properties":{},"type":"text","content":"âWeâre just at the tip of the iceberg in terms of all the hormonal shifts that are happening during the perimenopause, menopause transition,â she said. "},{"_id":"ILR5D3LQQJDUDDCCBOE33QN5EM","additional_properties":{},"type":"text","content":"âWeâre starting to understand a little bit more, but I think thereâs just so much.â"},{"_id":"OUPNL5RUPBAL7P7AILGKKJHNBI","additional_properties":{},"type":"text","content":"<i>For more information and to register, please click </i><a href=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\" target=\"_blank\" rel=\"\" title=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\"><i>here</i></a><i>. </i>"}],"subheadlines":{"basic":"CRNâs upcoming SciComms Connect symposium will highlight how womenâs health is attracting more research, investment, and product development, but translating that momentum into credible supplement products and consumer messaging remains challenging."},"description":{"basic":"The Council for Responsible Nutritionâs inaugural SciComms Connect symposium will address the challenges of translating growing research and investment in womenâs health into credible supplement products and consumer messaging. 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2039we communicate it, should reflect that,â Heather Woolery-Lloyd, MD, FAAD, board-certified dermatologist and chief medical advisor at Nutrafol and speaker at the upcoming symposium, told NI. "},{"_id":"5XZCZEDNJJENFAD5TMWFWCE7V4","additional_properties":{},"type":"text","content":"Dr. Woolery-Lloyd pointed to hair health as an example. Hormones, stress, nutrition, aging and lifestyle can all play a role, making evidence on a popular individual ingredient less informative than research demonstrating that a specific formulation improved a defined outcome in its intended population."},{"level":2,"_id":"LFJCL5KQBJARTLN5HJ4PN4KNKY","additional_properties":{},"type":"header","content":"What does âclinically studiedâ mean?"},{"_id":"WKQGMLRFIBEXBFJOJB7TZUJIMI","additional_properties":{},"type":"text","content":"Ryan Woodbury, co-founder and co-CEO of maternal nutrition company Needed, raised a similar concern around the way evidence is communicated."},{"_id":"UKJMSBBYN5GOBOHGXFSSMFQ3HM","additional_properties":{},"type":"text","content":"Growing investment in womenâs health has helped bring research and product innovation to previously overlooked areas, she said, but terms such as âclinically studiedâ and âclinically provenâ can obscure important distinctions."},{"_id":"BCXZDTE2XZHDXITF5VNISLETAA","additional_properties":{},"type":"text","content":"âSometimes only one ingredient was studied, rather than the finished product, or it was tested at a different dose, in a different population or for a different outcome than the product claims,â Woodbury told NI. "},{"_id":"YZNZQXRE25F43FEM5DCTVOSOOI","additional_properties":{},"type":"text","content":"For companies, that creates a communications challenge alongside the scientific one."},{"_id":"7KQUNPHDBJEGHLEEG2UYVZ2VYE","additional_properties":{},"type":"text","content":"âWe have learned that our job is to make the truth compelling...we can simplify the language without changing the evidence by remaining clear about who was studied, what was measured and how certain the conclusion is,â she added. "},{"level":2,"_id":"E5R2WE4POBDVVF4RLBRX4EFBLE","additional_properties":{},"type":"header","content":"Closing the distance between science and consumers"},{"_id":"F476NKRZGVEX7HM5ATA4PTKM5E","additional_properties":{},"type":"text","content":"SciComms Connect grew out of CRNâs previously separate Science in Session and WellComms programs. Ventura said CRN noticed attendees moving between the scientific and communications sessions when the programs were held side by side, pointing to a need for more interaction between the disciplines."},{"_id":"AZWAFIQ25RCETMRCCTRDGJFGV4","additional_properties":{},"type":"text","content":"The resulting symposium is intended to serve as what he called the âconnective tissueâ between the science itself and how it is ultimately communicated to consumers."},{"_id":"VUEQITTYAZF3LHQXRXIAJXS34E","additional_properties":{},"type":"text","content":"That connection has become more complicated as consumers increasingly turn to social media, influencers and artificial intelligence for health information, according to Ventura."},{"_id":"KAWK76BPABHHBARTTQSBW3OM7A","additional_properties":{},"type":"text","content":"âI think SciComms Connect ultimately is [â¦] figuring out how to sort of shorten the distance between the laboratory and the women who are trying to make decisions about their health,â he said."},{"_id":"ZIYUCENZURBNLAJZGMN56Q5CA4","additional_properties":{},"type":"text","content":"Wong said that work also needs to begin earlier within companies. Rather than handing a finished innovation to communications teams after formulation and legal and regulatory work are complete, she said scientific, regulatory, innovation and communications functions should work together throughout the process."},{"_id":"B5BYZLS7XBDQZFDSK6Y2RRFXEQ","additional_properties":{},"type":"text","content":"And despite the growing attention to womenâs health, significant scientific gaps remain."},{"_id":"HNJNZ4XAZZBIFMH6JRASGFACHY","additional_properties":{},"type":"text","content":"Wong pointed particularly to nutrition during the perimenopause and menopause transition and maternal health, including support for women during pregnancy and postpartum."},{"_id":"COFM2VQTYJHQBJ5LH4MHN3H6RQ","additional_properties":{},"type":"text","content":"âWeâre just at the tip of the iceberg in terms of all the hormonal shifts that are happening during the perimenopause, menopause transition,â she said. "},{"_id":"ILR5D3LQQJDUDDCCBOE33QN5EM","additional_properties":{},"type":"text","content":"âWeâre starting to understand a little bit more, but I think thereâs just so much.â"},{"_id":"OUPNL5RUPBAL7P7AILGKKJHNBI","additional_properties":{},"type":"text","content":"<i>For more information and to register, please click </i><a href=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\" target=\"_blank\" rel=\"\" title=\"https://web.cvent.com/event/b0d246c9-da8d-40b8-a1a9-72b27b92c8d7/summary?rp=1f9dc1c0-b307-4c86-97f7-c4a407c04bb2\"><i>here</i></a><i>. </i>"}],"subheadlines":{"basic":"CRNâs upcoming SciComms Connect symposium will highlight how womenâs health is attracting more research, investment, and product development, but translating that momentum into credible supplement products and consumer messaging remains challenging."},"description":{"basic":"The Council for Responsible Nutritionâs inaugural SciComms Connect symposium will address the challenges of translating growing research and investment in womenâs health into credible supplement products and consumer messaging. 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2039play/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/08/04/pg-to-acquire-thorne-in-premium-wellness-play/\">P&G, which acquired Thorne</a> to boost its personalized health portfolio for US$3.8bn in August 2026, and US company Hims & Hers Health, which also acquired Australiaâs Eucalyptus for up to US$1.15 billion in June 2026 to bring its personalized care service to international markets. "},{"_id":"TQQQCWPHKVBDRC3VDKLBZ7AHNU","additional_properties":{},"type":"text","content":"Direct customer relationships, recurring revenue and personalization are at the center of these deals. "},{"content_elements":[{"_id":"SX3ZEDHQX5FQJO4D7YTUNX2UJM","additional_properties":{},"type":"text","content":"Right now, weâre seeing some of the biggest names in global consumer health: Procter and Gamble, Nestle, Unilever, deploying billions of dollars into precisely this category â personalized subscription-led wellness. "},{"_id":"4MI2IK42GJCHZBU6ZPLC2VJFFI","additional_properties":{},"type":"text","content":"Weâre leaning into that same wave early and on terms that are genuinely disciplined for our shareholders, because thatâs the other thing I want you to hear clearly today. This is a capital light, largely deferred, performance-based structure. It protects our existing shareholders and it aligns Vitableâs team directly with the outcomes weâre all chasing together."},{"_id":"LPFMQ2ZUTZEVTIMNOOBUR7BXLU","additional_properties":{},"type":"text","content":"After a really challenging period of financial reset and fixing the underlying P&L, the exit of the non-core and underperforming US CBD business, weâre now starting to scale via acquisition, just as we told the market we would."}],"citation":{"type":"text","content":"Gavin Evans, independent non-executive chairman of Elixinol Wellness "},"subtype":"pullquote","_id":"O4W2IDWKJBCGPFKYROBHIDAS6Y","additional_properties":{"language":{"code":"en","region":"GB"}},"type":"quote"},{"level":2,"_id":"5EBDHV3AB5FERONXP7J7Y5RFGY","additional_properties":{},"type":"header","content":"Vitable to add over $5m of revenue "},{"_id":"2UPSPVIXHFHR3DOMOPKGSYXFAI","additional_properties":{},"type":"text","content":"Elixinol added that Vitable could add over A$5m of revenue, enabling the company to exceed A$20m in annual revenue. "},{"_id":"TDXCVI7IOZG3PMUU3Y3UE4JWPQ","additional_properties":{},"type":"text","content":"This is supported by Vitableâs recurring subscription revenue and direct consumer capability. "},{"_id":"J6UUMJLRCFAI3AEGUVTP6EDE4I","additional_properties":{},"type":"text","content":"The combined business is targeting A$27m in revenue and approximately A$3m of EBITDA by 2028. "},{"_id":"WCS54F2TQRGRZKPOF3LILTDLUE","additional_properties":{},"type":"text","content":"âVitable brings Elixinol an established subscription-based consumer platform, proprietary personalization capability and direct consumer relationships. 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"},{"_id":"LPTPF23GSVA7XNKF5LAMR5QN4U","additional_properties":{},"type":"text","content":"She explained that ârather than wait until all of those caught up to where we needed, we figured we would start to help the process by building the foundation.â "},{"_id":"UXEBTLRVZVGILHF3A2ZSTPKPSE","additional_properties":{},"type":"text","content":"Ancient Nutrition and Rodale Institute first partnered in 2021 and renewed the collaboration in early 2026. Rodaleâs Organic Consulting team is working directly with farmers, providing agronomic guidance, soil-health support and assistance preparing for organic and Regenerative Organic Certified certification."},{"level":2,"_id":"LHFTOJVXBVHM7LTK45UDHOS6FM","additional_properties":{},"type":"header","content":"From the farm to a usable ingredient"},{"_id":"JRANEGV3SBGWXEUITNQ7YEV2W4","additional_properties":{},"type":"text","content":"Working directly with farmers addresses only part of the sourcing equation."},{"_id":"OXKZHT5M5BEWNHV26EBVP72FHQ","additional_properties":{},"type":"text","content":"Ancient Nutrition has found farmers with crops it wants to source, as well as farmers willing to grow them. The harder part has been finding enough certified processing capacity to turn those crops into ingredients the company can use."},{"_id":"LBRXKEEF7RDZTGN5UILLVXDKGQ","additional_properties":{},"type":"text","content":"âIn one word: processing,â Cerutti said of the biggest challenge. "},{"_id":"TPKHPJ4MEBGDRNYX4N2A4LZN6E","additional_properties":{},"type":"text","content":"âWe have found several farmers who either have the ingredients, or are willing to grow them, but the crops are not in the form that we need them, and we have not found enough certified processors to help with this in a cost-effective way,â she shared. "},{"_id":"6WAN4EQU5FDCFOYWBI76FY7VJI","additional_properties":{},"type":"text","content":"Cost and demand further complicate the equation. Farmers have to consider the economics of certification and whether a premium market will exist for what they produce. Brands face uncertainty of their own around ingredient volumes, pricing and demand for products that may still be in development."},{"_id":"ULB744LBUZEPDMFNVAGK6E7FVU","additional_properties":{},"type":"text","content":"Scale presents another challenge. Cerutti said aggregating ingredients from multiple small farms requires significant work from a brandâs internal team, whereas relying on a single farm can create supply risk."},{"_id":"BOEB6KKTXRHPHAJUEKBMFF5XGY","additional_properties":{},"type":"text","content":"âThat is why we believe collaboration is so important...brands, farmers, ingredient suppliers, processors, nonprofits and certification organizations all have a role to play,â she said. "},{"level":2,"_id":"RB76KQUS3FDCZCDZIC3BTH6QBE","additional_properties":{},"type":"header","content":"Measuring progress upstream"},{"_id":"HLKTHDD4NRDZHPDVXDZ2QKHR4U","additional_properties":{},"type":"text","content":"The renewed partnership is expected to generate reporting on acres impacted, farmer profiles, certification milestones and project outcomes."},{"_id":"RQORHBDBJZARPE2POIV524BJSE","additional_properties":{},"type":"text","content":"Cerutti said Ancient Nutrition looks beyond the number of acres and farms transitioned when assessing its work. At the farm level, the company considers soil health, biodiversity, water and carbon. It also looks at farmer education, economic viability, community and access to resources."},{"_id":"DF66OH5M3ZDZDJWT6GFSODFFJ4","additional_properties":{},"type":"text","content":"Some of that work extends beyond farms that ultimately become Ancient Nutrition suppliers. Through its R.A.N.C.H. Project, the company has participated in research projects, planted perennial food forests, addressed food waste and supported seed bank concepts."},{"_id":"2YQ74KCRYFB2XNC5UPXZV4BV5U","additional_properties":{},"type":"text","content":"Greater involvement at the farm level also provides the company with more visibility into how ingredients are grown and the practices and certifications behind them. Cerutti said the environmental benefits remain important, but developing the supply chain itself is central to the work."},{"level":2,"_id":"MJ2NUX2BJ5DTLFSNR727WMIR4I","additional_properties":{},"type":"header","content":"Building supply before buying it"},{"_id":"VH6AIM2D5VC7PHD3ZBKNXDC27Q","additional_properties":{},"type":"text","content":"The model requires brands to take on a role that starts well before an ingredient is ready for procurement."},{"_id":"CRUOFRCL2ZF5FO5JOSU3ZJFQAM","additional_properties":{},"type":"text","content":"Cerutti said companies interested in regenerative sourcing may need to invest in farmer transitions, support research and education, develop longer-term relationships and help create demand for what farmers produce. 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2039cing the associationâs reputation as a trusted advocate grounded in science. The Boardâs search process for Melvilleâs replacement will be led by Greg Bradley, Chairman of Foundation Consumer Healthcare and Chair of the CHPA Board of Directors, and Chair-elect Phil McWaters, SVP and General Manager, North America Personal Health Care at Procter & Gamble, in collaboration with the CHPA Executive Committee."},{"content_elements":[{"_id":"SAXMQZ7VBRD3RKRYCOMXU5YC5Q","additional_properties":{},"type":"text","content":"I am incredibly proud of what we have accomplished together on behalf of our members and the consumers who rely on self-care products every day. As for whatâs next, Iâm looking forward to spending more time with my family while staying engaged in new ways â serving on boards and committees, volunteering for organizations I care deeply about, and becoming more active in civic and political life."}],"citation":{"type":"text","content":"Scott Melville, President and CEO, CHPA"},"subtype":"blockquote","_id":"GZRQIGB2SJAXJE3IWVUJKOB4N4","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"WYF444CH4ZHX7IFGRANEDTUH4U","additional_properties":{},"type":"text","content":"<b>The Vitamin Shoppe</b> promoted <b>Jack Gayton</b> to senior vice president of merchandising, reporting directly to CEO Sharon Leite. He assumes the top merchandising role from <b>Muriel Gonzalez</b>, president of The Vitamin Shoppe, who announced her retirement in August from a retail career spanning more than four decades. Since joining The Vitamin Shoppe in 2019 as a senior buyer, Gayton has taken on increasing responsibility across the merchant team and is now charged with advancing the The Vitamin Shoppeâs business priorities by anticipating changing customer needs, moving quickly on emerging trends, and working closely with brand partners to bring differentiated products and experiences to market."},{"_id":"J54NA3CU2JGB7KJWQQTKGNPCXQ","additional_properties":{},"type":"text","content":"As part of the new merchandising structure, <b>David DiTota </b>has been promoted to vice president, divisional merchandise manager, and will help lead the retailerâs third-party assortments and further opportunities across high-growth wellness categories."},{"_id":"IWR6XBIRKVB2BNZMKMM47NVE6M","additional_properties":{},"type":"text","content":"<b>The Vitamin Shoppe</b> also appointed <b>Kimberley Gardiner</b> as EVP, chief marketing and growth officer to oversee brand strategy and creative to oversee brand strategy and creative, performance marketing, e-commerce, CRM and personalization, loyalty, and corporate communications and public relations. Gardiner has held senior leadership roles at Tractor Supply Company, Volkswagen, Mitsubishi Motors North America and Kia Motors America. In her new role, she will contribute to the continued evolution of The Vitamin Shoppe as a more digitally connected and customer-centric wellness platform. "},{"content_elements":[{"_id":"JQMADWEUP5DK7LKHAGWLCHSMBI","additional_properties":{},"type":"text","content":"âKimberley is an exceptional marketing leader with a proven ability to reinvent established brands and turn customer insights into measurable growth,â Leite said. âAs The Vitamin Shoppe prepares to celebrate its 50th anniversary next year, we have an opportunity to build on decades of customer trust and loyalty while reimagining how we engage with the modern wellness consumer. "}],"citation":{"type":"text","content":"Sharon Leite, CEO, The Vitamin Shoppe"},"subtype":"blockquote","_id":"QCAUUCHZINGMJCENPG7NUIFNEY","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"OLMGEKAJ4FD3PD7SZTT2YEQVQU","additional_properties":{},"type":"text","content":"<b>ADM</b> created a new EVP & COO role for former Syngenta CEO <b>Jeff Rowe</b>, where he will oversee the companyâs commercial businesses, global manufacturing and R&D efforts. At Syngenta, Rowe led efforts to advance sustainable farming and AI-powered innovation and spent over 20 years in executive positions at DuPont Pioneer spanning strategy, international operations, biotech and regulatory affairs. He is also a fifth-generation farmer, helping to run his familyâs regenerative farm in Illinois and has a Bachelor of Science in Agricultural Economics from Iowa State University, a Juris Doctorate from Drake Law Sc
2039hool and a Global Executive MBA from the NYU Stern School of Business and the London School of Economics."},{"_id":"HG6J5DFZLREDJM5JICKMLESJFA","additional_properties":{},"type":"text","content":"<b>Freemen Nutra</b> named <b>Joseph Chiang</b> as its new global CEO to lead the companyâs next phase of global expansion and brand evolution. Chiang has held executive positions at Amway/Nutrilite, Glanbia and Howtian, with experience spanning strategic transformation, global sourcing and building high-performance organizations within complex international markets."},{"_id":"IECOIC3AOVDO5MDGB4EYADQHAY","additional_properties":{},"type":"text","content":"Contract manufacturer <b>Vitaquest International </b>appointed <b>Luigi Cappello</b> as chief commercial officer (CCO) to help drive the companyâs continued growth, customer engagement, innovation and market expansion. Cappello brings more than 20 years of leadership experience across consumer health, healthcare and branded businesses, most recently serving as chief commercial officer at Helen of Troy. His career also includes senior leadership roles at Sanofi, Bayer Consumer Care and Merck Consumer Care."},{"_id":"LRUQZ3KPDVDN5P5DGUCQI5JNTI","additional_properties":{},"type":"text","content":"<b>Saanroo</b> hired <b>Mukeshkumar Chauhan</b> as deputy general manager for the India & South West Asia region, a new position created as part of an expansion of operations to India. In his new role, Chahan will lead commercial initiatives for Saanroo India, strengthening customer relationships, expanding strategic partnerships, and supporting the companyâs continued regional growth. Chauhan joins Saanroo from Ashland, where he played a key role in establishing and scaling the companyâs film-coating business in India. He brings more than 15 years of experience in sales, marketing and business development across the pharmaceutical and nutraceutical industries, with extensive expertise in commercial strategy, customer engagement and market development. "},{"content_elements":[{"_id":"RYFKHNL74VELNJ6XNNXSCI7LMA","additional_properties":{},"type":"text","content":"âThis investment marks the next phase of Saanrooâs global growth strategy, By expanding our regional capabilities and deepening our presence in key markets, weâre positioning the company for long-term growth and strengthening our ability to work more closely with customers and support the future of science-driven wellness.â"}],"citation":{"type":"text","content":"John Quilter, CEO of Saanroo"},"subtype":"blockquote","_id":"VRWV67JIGFEQTMRZMB4GSSKMVA","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"UZWWPI32YFEG3O4XPLNL3IQXPE","additional_properties":{},"type":"text","content":"<b>STAUBER </b>appointed <b>Adam Adelmann</b> as vice president, commercial â food & health sciences to advance the ingredient supplierâs growth strategy and strength, customer and supplier relationships across its markets. Adelman has over 20 years of B2B industry experience in consumer health with 10 years in strategic and tactical leadership at companies including Capsugel, Capstone Nutrition, Lonza and most recently at OmniActive Health Technologies as chief commercial officer and president of core markets."},{"_id":"A7SDZVZYWZBPXBQ24E6SNIBUZM","additional_properties":{},"type":"text","content":"<b>Aaron Heidebreicht</b> joined Swiss nutrition company <b>KA-EX</b> as CEO, North America. Heidebreicht previously led Applied Nutritionâs North American business. "},{"_id":"OJGGXTIGK5GRFHVGPDD6Z7DNNY","additional_properties":{},"type":"text","content":"<b>Seppic</b> appointed <b>Virginie Cavalli</b> as CEO. With a degree from EMLyon school in business and financial strategy, Cavalli joined the parent company Air Liquide Group in 1992. She has since served across business units in France, the United States, Chile and Singapore. Most recently, she served as CEO for Air Liquide in Japan and has been deputy group vice president of human resources for the group since 2023."},{"_id":"ET2OV2DFLZC6HBG6YQTULOXYFY","additional_properties":{},"type":"text","content":"<b>
2039Mo Lababidi</b> rejoined <b>Alkemist Lab</b> as director of botanical identity to help drive innovation and operational excellence. He previously spent more than a decade at Alkemist, advancing through key laboratory and leadership positions, before spending over six years at Tentamus California as department manager and lab activities director. He holds an MBA from the University of Redlands and a degree in chemistry from California State University, Long Beach."},{"content_elements":[{"_id":"5WVWOKBIMJE3NNVH6ALJXUCKFI","additional_properties":{},"type":"text","content":"âMoâs return to Alkemist is meaningful on many levels. He spent 11 years helping build the culture of quality and scientific rigor that defines our company today. Since then, he has broadened his leadership experience and operational expertise and now returns with an even stronger perspective.â"}],"citation":{"type":"text","content":"Elan Sudberg, CEO of Alkemist Labs"},"subtype":"blockquote","_id":"DFOHW4PI75HG3I32ZFN6LKDJYA","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"TN7QAUDOJFCA3EJPIMKGF7STO4","additional_properties":{},"type":"text","content":"Danish microalgae ingredients startup <b>Algiecel </b>appointed <b>Mette Ingeman Pedersen</b> as chief financial officer and <b>Tove Feld</b> to chair its board of directors. The appointments strengthen a female-led leadership team headed by CEO Sus
2039anne Palsten Buchardt and support Algiecelâs next phase of growth, building the financial, operational and governance capabilities needed to scale its controlled marine bioactives platform for nutrition, pet food and personal care markets."},{"_id":"MMR5ACCY3ZHILMIT4GZAYSPIFE","additional_properties":{},"type":"text","content":"<b>Hannah Spencer Ackermann,</b> RDN, joined DMC Biotechnologies, Inc. as director of product management after six years at COMET, where she moved from marketing manager in 2020 to vice president of marketing and nutrition affairs. With a BA in Journalism and BS in Dietetics from Indiana University Bloomington, previous roles include consumer insights analyst at Mintel, food & nutrition specialist at Ketchum and food & nutrition communications at Edelman. In her new role, she will raise help awareness about DMCâs precision fermentation myo- and D-chiro inositols and the overall inositol category."},{"_id":"GB6CMI3KBVDRXNRYHEVMDBUJLQ","additional_properties":{},"type":"text","content":"<b>Barentz</b> appointed <b>Isabela Trad</b> as head of human nutrition South America to accelerate growth across its human nutrition business in the region. She has held key roles in multinational ingredient companies, including recent experiences at Ingredion and Tate & Lyle, where she focused on specialty ingredients and health-focused solutions across Latin America. "},{"_id":"3C2ZCTNNVBDBPA7TZISU77YLBA","additional_properties":{},"type":"text","content":"<b>Matt Schiffman</b> joined <b>Rho Nutrition</b> as VP of Retail Sales. Most recently, he helped lead retail growth at Bubble and Gainful, driving partnerships and expansion across major retailers. Previously, he held brand leadership roles at RSP Nutrition, where he helped build and grow a portfolio of performance nutrition products. At Rho, he is charged with leading retail strategy and expansion to bring Rhoâs liquid liposomal nutrition to more consumers."},{"_id":"AF3XMB4TXRE6ZF26L5SKWWGT5M","additional_properties":{},"type":"text","content":"<b>Bastyr University</b> appointed<b> Randy Frisch, PhD, JD, MBA, </b>as the universityâs seventh president in its 48-year history. He succeeds interim Bastyr University president and co-founder <b>Dr. Joseph Pizzorno</b>, who transitioned to a role as Bastyrâs first chancellor. Before joining Bastyr University, Dr. Frisch was president of City University (CityU) Seattle from 2013 to 2024 and served as general counsel for CityUâs parent organization, National University, a private, non-profit system of higher education with 25,000 students and 3,000 employees. In the coming academic year, Dr. Frisch will oversee the continued refinements to university operations and programs to lower cost barriers and help more students access excellent naturopathic medicine and aligned health sciences higher education."},{"content_elements":[{"_id":"YRMZJPIGDNAU3PHU5SG2S7N45U","additional_properties":{},"type":"text","content":"âDr. Randy Frisch is a brilliant leader with the knowledge and expertise to advance our beloved university in all the right ways. President Frisch and I have worked closely together, over the last year, to rebuild the universityâs finances and refine its academic programs. Dr. Frisch is the architect of the universityâs turnaround plan. With his guidance, we returned Bastyr to financial stability while reducing costs for our largest academic program, the naturopathic medicine doctorate.â"}],"citation":{"type":"text","content":"Dr. Joe Pizzorno, Co-found and Chancellor of Bastyr University"},"subtype":"blockquote","_id":"FDDAWX2OKVGIDAUUPCXP6WJRAQ","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"WEK2NENQ55C55N4MORFIMHAELA","additional_properties":{},"type":"text","content":"<b>Ritual </b>promoted <b>Brittany Cox</b> from senior manager of product development to director of product development. Prior to joining Ritual in 2024, she led product development at UST MFG, held senior product scientist and formulation roles within the industry, and earned her Bachelor of Science from Brigham Young University â Idaho, followed by an MBA from Western Governors University."},{"_id":"MO6ZJXWNC5DOTFX7YKFZTGANYE","additional_properties":{},"type":"text","content":"<b>Kyle Maurer</b> joined <b>resbiotic </b>as chief marketing officer to help showcase the companyâs rigorous science as it continues to expand across retail, e-commerce, healthcare practitioners and international markets. He brings experience in DTC and omnichannel strategy, subscription economics, incrementality-led media and mix modeling, influence and creator programs and AI marketing operations and has held senior marketing roles at Gorilla Mind and Monster Energy. He holds a BA in communication and media studies from The Ohio State University and an executive MBA from Vanderbilt University Owen Graduate School of Management."},{"_id":"2O7P4NNEBJCVZGCHJUDXQNXUPI","additional_properties":{},"type":"text","content":"<b>SIRIO Europe</b> appointed <b>Kasia Kortmann</b> as general manager of European business. She previously served as general manager for DACH (Germany, Austria & Switzerland), Benelux and the Nordics and VP of Commercial Transformation Europe at Ontex. Earlier in her career, Kortmann spent several years at Procter & Gamble, across local markets and EMEA HQ, where she managed multiple regions. She joins the business at a period of strong growth. SI
2039RIOâs European revenue reached â¬93.8 million in 2025, up 24.95% year on year, making Europe the companyâs fastest-growing region. In her new role, Kortmann is charged combining the companyâs pharmaceutical heritage and global scale to define a clear long-term strategy to build an organization that can execute consistently across every market and capitalizing on the momentum in longevity, active lifestyle nutrition, beauty from within, and womenâs and childrenâs health."},{"_id":"BXOOWI3LVVDPHGK4UHCMYL3JOA","additional_properties":{},"type":"text","content":"Model, entrepreneur and wellness advocate <b>Carolyn Murphy </b>joined <b>Infinity Wellness</b> as partner and chief brand officer. The appointment marks a defining moment for Infinity Wellness as it evolves from a pioneer in whole-food greens into a broader wellness platform. In this role, Murphy will lead the creative vision for Infinity Wellness, shaping brand storytelling, product positioning, creative direction and consumer experience while helping guide the companyâs long-term strategic growth. Founder Billy Merritt continues to serve as chief innovation officer, leading product formulation and education, and CEO Lars Hem will continue to oversee the companyâs strategic direction and operations."},{"_id":"XHJ7OCOONNGNBM2SF7TS24BPVQ","additional_properties":{},"type":"text","content":"Nestlé Coffee & Beverage Division President <b>Daniel Jhung</b> was promoted to president of <b>Nestlé Health Science US</b>, describing the appointment as a homecoming. His first role at Nestlé in 2007 was marketing manager for Carnation Breakfast Essentials, which would later become the Nestlé Health Science division. He holds a BA in economics from Stanford University and an MBA in general management from Harvard Business School."},{"content_elements":[{"_id":"S7UDSFKHSFDXBOZTLYKF3ATQRY","additional_properties":{},"type":"text","content":"Health Science holds a unique place within Nestlé. The work here matters in a very real wayâhelping patients and consumers live healthier, better lives through science and nutrition."}],"citation":{"type":"text","content":"Daniel Chung, President, Nestlé Health Science US"},"subtype":"blockquote","_id":"EBHP42KNKRA7HILRIEFVAWNBNU","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"DZCX6F6TQRB2PICV5XKJ3PVAB4","additional_properties":{},"type":"text","content":"<b>Courtney Jackson</b> was promoted to manager of regulatory & scientific affairs at <b>Nestlé Health Science</b>. Jackson joined the company full time as principal nutritionist in 2023 after serving as director of research & development and vice president of nutrition at Persona, then a Nestlé Health Science company. She earned her BA in nutrition sciences from Bastyr University and holds a Master of Public Health in nutrition from Liberty University."},{"_id":"U2S6MPKTEZHO7AABSX62YZI3JU","additional_properties":{},"type":"text","content":"<b>Rania Abou Samra</b> joined <b>Lesaffre International SARL</b> as chief research, development & innovation officer, working across the group and with the Lesaffre Institute of Science and Technology to expand the potential of fermentation to address major food, health and environmental challenges. Abou Samra, who hold a degree in nutrition from the University of Toronto, joined Nestlé in 2007 as a clinical research scientist in Switzerland and progressed through various R&
2039D roles over the next 18 years. More recently, she was appointed VP research & development for Vital Proteins before being named VP and global head of technology and product development, as well as head of R&D US at Nestlé Health Science. Since April 2024, she served as VP and head of innovation and R&D for Nestlé Middle East and North Africa."},{"content_elements":[{"_id":"6CU5DQS6INFXPETBYIIWXVIWFQ","additional_properties":{},"type":"text","content":"âI share Lesaffreâs conviction that fermentation is a key technology for sustainable innovation. RD&I is a driving force that enables us to support our customers, anticipate food and environmental transitions, and transform scientific knowledge into concrete, sustainable solutions.â"}],"citation":{"type":"text","content":"Rania Abou Samra, chief research, Chief Development & Innovation Officer, Lesaffre International"},"subtype":"blockquote","_id":"PZQOANBESZCXNOAMKLG2AS4EG4","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"V222RZDTOBFOBMFXL2WUZMJLCQ","additional_properties":{},"type":"text","content":"After eight years at Nestlé Health Science in Medical Nutrition, <b>Natalya Kirilyuk</b> started a new chapter as global category lead â weight management & GLP-1 at <b>Nestlé</b>. She began her career at Nestlé in 2013 as project leader on the strategic innovation team before joint Nestlé Health Science in 2018, where she built expertise across medical nutrition, category leadership, and global brand and business initiatives."},{"_id":"PITUHJ6AHFCF5NGAY7C7AWHJSA","additional_properties":{},"type":"text","content":"<b>Constanza Stocchi</b> started a new role as nutrition & scientific affairs manager at <b>Nestlé</b>. An HCPC-registered dietitian and nutrition scientist and graduate of Kingâs College London, Stocchi worked across pediatric dietetics in the National Health Service in the UK and medical nutrition roles in industry."},{"_id":"ESL4X4BIDVFU7M3ZDNZQSZNNSE","additional_properties":{},"type":"text","content":"<b>Ocean Spray Cranberries</b> welcomed <b>Abigail Buckwalter</b> as president and CEO. A leader at Nestlé Health Science U.S. since its inception 15 years ago, Buckwalter held roles across Europe, Oceania, and North America and most recently served as CEO for the past three years."},{"content_elements":[{"_id":"UWFJWR5AL5HJFA73BBWYB2P5SQ","additional_properties":{},"type":"text","content":"âOur industry finds itself at an incredibly dynamic tipping point in consumer behavior and buying habits. I believe Ocean Spray, with its iconic brand and global platform, is uniquely positioned to deliver against those expectations around taste and health benefits.â "}],"citation":{"type":"text","content":"Abigail Buckwalter, president and CEO, Ocean Spray Cranberries"},"subtype":"blockquote","_id":"DFOSU5CJIJD3BC7DEX64SXSP3Q","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"775SPAH77RA5DDWUUWP6ZRYPOE","additional_properties":{},"type":"text","content":"<b>Michael Messina</b> started a new position within the <b>Unilever Wellbeing Group</b> as vice president of quality & regulatory - VMS Co-Op, supporting OLLY PBC and SmartyPants Vitamins. He previously led quality initiatives at Kenvue and DSM and holds a MS in molecular biology from Montclair University and PhD in cell and developmental biology from Rutgers Robert Wood Johnson Medical School."},{"_id":"ZFK54O5ORREWXF57Z3IAUWLH2M","additional_properties":{},"type":"text","content":"<b>Aaron Jones</b> took over as marketing officer at <b>Grüns</b> to help scale growth after the greens gummy unicorn was acquired for $1.2 billion by Unilever a month prior. Jones previously served as chief digital officer at Liquid I.V. (also part of the Unilever Wellbeing Collective) where he specialized in e-commerce strategy, digital marketplace integration and multi-channel marketing campaigns, and held digital leadership roles with Unilever."},{"_id":"ZYY5I2XVYNFJNML3K4JLSDQ6OY","additional_properties":{},"type":"text","content":"Dutch ingredient supplier <b>IMCD Group </b>appointed <b>Walter Ripple</b> as executive vice president, commercial, US. With this newly created role, IMCD says it is focusing on deepening supplier and customer relationships, driving portfolio excellence and accelerating organic growth. Ripple joins from Avient Corporation, where he spent over 27 years in sales and senior leadership roles. He holds a Bachelorâs of Chemistry from Texas A&M University and an Executive MBA from the University of Michiganâs Ross School of Business."},{"content_elements":[{"_id":"XBF4WYIGN5CH7GKY2ETJTUL52E","additional_properties":{},"type":"text","content":"Walter Ripple is a strong addition to our team and his appointment reflects our ambition clearly. We have great suppliers and customers in the US, and our job is to make sure we are doing everything we can to help them grow. Walter brings the commercial depth and industry experience to help us do exactly that, and I am looking forward to what we will build together."}],"citation":{"type":"text","content":"Vlad Miller, President, US, IMCD"},"subtype":"blockquote","_id":"BNNFZGNGUBARDJEDPI3H3QH744","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"DOSFL6WMQNEQ3PWSVR6VIYJVOM","additional_properties":{},"type":"text","content":"<b>IMCD Group</b> also promoted long-time employee <b>Mary Lim</b> to global vice president of technical, food & nutrition. Lim joined the company as technical manager in 2010 and previously held a similar role at ingredient supplier Nealanders International before it was acquired by Caldic B.V. "},{"_id":"G2ZFKRK3TZBB3IIZUQDMORFR6Y","additional_properties":{},"type":"text","content":"<b>Helia Santos</b> stepped into the role CEO at <b>Double Wood Supplements. </b>With 20 years of experience spanning finance, marketing, sales, and general management, she joins from Opella, where she served as head of integrated commercial strategy and then driving growth as president & general manager- Qunol. "}
2039,{"_id":"TCT2RT4UMZFAFFF4IZRSHSPH74","additional_properties":{},"type":"text","content":"<b>Aker BioMarine</b> appointed <b>Margaret Ng</b> as its new West Coast sales director for human health ingredients to drive growth for the companyâs B2B ingredient portfolio including Superba Krill Oil, Revervia and Lysoveta and PL+. She brings over 15 years of nutraceutical and contract manufacturing experience cultivated through sales roles at PAT Vitamins, CAPTEK Softgel International and most recently at senior account manager for nutrition at Actylis."},{"_id":"XKIFNBMAWNEULKYHGDMFQPFQ6Y","additional_properties":{},"type":"text","content":"<b>Sabinsa </b>announced <b>Brandon Prenger</b> as the companyâs new director of business development. He previously held business development roles at INS/Innovative Natural Solutions, SpecNova, Nutragenesis/Innophos Nutrition, Deerland Enzymes and National Enzyme Company where he built and grew sales territories, cultivated strategic relationships with R&D and product development teams, and helped bring clinically supported branded ingredients to market. Prenger holds a Bachelor of Science in animal science from Southern Illinois University. "},{"content_elements":[{"_id":"Z7WZOSJEPVDPRCA546EHBGUHXE","additional_properties":{},"type":"text","content":"Brandonâs extensive industry experience across diverse market channels and health categories gives him a unique ability to help our customers identify innovative solutions from Sabinsaâs broad portfolio of science-backed ingredients."}],"citation":{"type":"text","content":"â said Shaheen Majeed, Global CEO & Managing Director, Sabinsa"},"subtype":"blockquote","_id":"BJ2CWBJDFRBTFN6DHGRQUP2DTA","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"},{"_id":"A756OVE2JFGDBBCQNX6RN7GD3E","additional_properties":{},"type":"text","content":"<b>BioTRUST Nutrition</b> named <b>Rachel Sexton</b> as president to spearhead a strategy to evolve BioTRUST from a product-led nutrition company into a trusted healthspan platform. A graduate of New York Universityâs Stern School of Business, Sexton spent more than a decade at Reckitt in leadership roles spanning innovation, strategy, portfolio management and brand transformation and later served as a senior executive at Wellbeam Consumer Health before most recently serving as chief marketing officer, North America, at Flora Food Group. She is also the creator of <i>Limitless Boundaries</i>, a platform dedicated to advancing human potential in an age of accelerating intelligence."},{"_id":"BSKTYRQRBBGSTM4CO2PYWJBG4I","additional_properties":{},"type":"text","content":"<b>Infinite Roots</b> promoted <b>Franziska Ploch </b>from head of supply chain to director of operations. A graduate of Hamburg University of Technology, Ploch previously held roles as junior specialist at McKinsey & Company, manager of digital industrial engineering at Beiersdorf before joining Infinite Roots as strategic operations manager of supply chain in 2023."},{"_id":"TT4VILUDCVBYNMA3ETTGMNCI5Y","additional_properties":{},"type":"text","content":"National Institutes of Health (NIH) Director Jay Bhattacharya, MD, PhD, announced <b>Wendy Weber</b>, ND, PhD, as director of <b>NIHâs National Center for Complementary and Integrative Health (NCCIH)</b>. Since October 2025, Dr. Weber has provided scientific leadership and strategic counsel and contributed to budget oversight to NCCIH as acting deputy director. As the head of NCCIH, Dr. Weber will manage the administration of the centerâs approximately $170 million budget. NCCIH supports research that aims to determine the fundamental science, usefulness and safety of complementary and integrative health approaches and their roles in improving health and health care. Prior to joining NIH as a program director in 2009, she led clinical investigations of complementary health interventions at Bastyr University, Kenmore, and Massachusetts General Hospital, Boston. As a faculty member at Bastyr University, Dr. Weber conducted clinical trials of botanical interventions, including echinacea for the common cold. She was the first naturopathic physician to receive an NIH career development (K) award, which supported her
2039clinical trial of St. Johnâs Wort for attention-deficit/hyperactivity disorder. She received her N.D. from Bastyr University, Kenmore, and a Master of Public Health and PhD from the University of Washington, Seattle. "},{"content_elements":[{"_id":"DYQ7U5FOFFGJFAVVFG6YGDAU5U","additional_properties":{},"type":"text","content":"As the home of complex, multi-system health research, NCCIH is central in our mission to understand multifaceted chronic diseases and the role of nutritional interventions on health. Dr. Weberâs history of leadership in whole-person health, pain management research, and deep connection to NIH make her a natural fit to lead the center into a new chapter of rigorous scientific discovery."}],"citation":{"type":"text","content":"Jay Bhattacharya, director, National Institutes of Health"},"subtype":"blockquote","_id":"5BKDFUNIENCPXP67BWHVTA2L6A","additional_properties":{"language":{"code":"en","region":"US"}},"type":"quote"}],"subheadlines":{"basic":"The latest executive moves suggest a nutrition industry entering a more institutionalized and global phase of growth and professionalizing around scale, science and channel expansion."},"description":{"basic":""},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Markets-trends","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Markets & trends","description":"","_id":"/News/Markets-trends","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News","weekly-newsletter-sections":"/"},"website":"nutraingredients-v2","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"navigation":{"nav_title":"Markets & trends","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Markets-trends"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Markets & trends","_id":"/News/Markets-trends","ancestors":{"weekly-newsletter-sections":["/"]},"order":{"default":4,"main-navigation":4,"weekly-newsletter-sections":1005}}},"_website_section_id":"nutraingredients-v2./News/Markets-trends","type":"section","version":"0.6.0"},{"path":"/Regions/Europe","parent":{"default":"/Regions"},"_website":"nutraingredients-v2","parent_id":"/Regions","name":"Europe","description":"","_id":"/Regions/Europe","additional_properties":{"original":{"parent":{"default":"/Regions","main-navigation":"/Regions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Europe","root_section":"false","type":"region"},"_admin":{"alias_ids":["/Regions/Europe"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Europe","_id":"/Regions/Europe","regions_tabs":{"latam":"false","emea":"false","apac":"false","noam":"false"},"order":{"default":35,"main-navigation":35}}},"_website_section_id":"nutraingredients-v2./Regions/Europe","type":"section","version":"0.6.0"},{"path":"/Regions/Asia-Pacific","parent":{"default":"/Regions"},"_website":"nutraingredients-v2","parent_id":"/Regions","name":"Asia Pacific","description":"","_id":"/Regions/Asia-Pacific","additional_properties":{"original":{"parent":{"default":"/Regions","main-navigation":"/Regions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Asia Pacific","root_section":"false","type":"region"},"_admin":{"alias_ids":["/Regions/Asia-Pacific"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Asia Pacific","_id":"/Regions/Asia-Pacific","regions_tabs":{"latam":"false","emea":"false","apac":"false","noam":"false"},"order":{"default":36,"main-navigation":36}}},"_website_section_id":"nutraingredients-v2./Regions/Asia-Pacific","type":"section","version":"0.6.0"},{"path":"/Regions/Latin-America","parent":{"default":"/Regions"},"_website":"nutraingredients-v2","parent_id":"/Regions","name":"Latin America","description":"","_id":"/Regions/Latin-America","additional_properties":{"original":{"parent":{"default":"/Regions","main-navigation":"/Regions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Latin America","root_section":"false","type":"region"},"_admin":{"alias_ids":["/Regions/Latin-America"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Latin America","_id":"/Regions/Latin-America","regions_tabs":{"latam":"false","emea":"false","apac":"false","noam":"false"},"order":{"default":37,"main-navigation":37}}},"_website_section_id":"nutraingredients-v2./Regions/Latin-America","type":"section","version":"0.6.0"},{"path":"/Regions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Regions","description":"","_id":"/Regions","additional_properties":{"original":{"parent":{"
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href=\"https://www.njleg.state.nj.us/bill-search/2026/A5487/bill-text?f=A5500&n=5487_I1\" target=\"_blank\" rel=\"\">NJ Assembly Bill A5487</a> was introduced by Shanique Speight on September 14. Speight was co-sponsor on a similar unsuccessful bill that was introduced a couple of years ago. That older bill did pass the Assembly in New Jersey, but did not advance through the stateâs senate. "},{"_id":"R6ET2ZX7JJHJVF7B742FWN2YBQ","additional_properties":{},"type":"text","content":"The bill targets âcertain diet pills and dietary supplements for weight loss or muscle building to persons under 18 years of age under certain circumstances.â It requires age verification using government-issued identification for all in-person and virtual sales and allows for fines of not more than $750. "},{"_id":"OQ5ALONSVRH4PKWTIWOE266ZVM","additional_properties":{},"type":"text","content":"The bill also targets specific ingredients, including creatine, green tea extract, raspberry ketone, garcinia cambogia, or green coffee bean extract."},{"_id":"KYX6RYOO7JCQ3GGMZG275PPGJU","additional_properties":{},"type":"text","content":"Kyle Turk, vice president of government affairs at the Natural Products Association (NPA), said he does not anticipate any movement on the bill during the current legislative session but described A5487 as a âholding billâ that will carry over to the next year. "},{"_id":"4242ASRG7FHY7BGW5YK3EDX64M","additional_properties":{},"type":"text","content":"While Turk doesnât anticipate a public hearing on the bill any time soon, he said NPA will be visiting the NJ state capitol in Trenton to reinforce with legislators that this is a non-starter for the dietary supplements industry. "},{"level":2,"_id":"U24NYXLZQJFPTFQVDV4UOK3RYU","additional_properties":{},"type":"header","content":"STRIPED"},{"_id":"NCBSOPOETRAXHEPVQNEOITODN4","additional_properties":{},"type":"text","content":"The Rhode Island bill is the latest in a series of state proposals seeking to restrict youth access to certain dietary supplements, particularly those marketed for weight loss or muscle building."},{"_id":"MNWIV2L5ZRBJDNGLBVALKHPILU","additional_properties":{},"type":"text","content":"Similar measures have been introduced in multiple states in recent years, most recently in states like <a href=\"https://www.nutraingredients.com/Article/2026/02/03/hawaii-seeks-to-restrict-access-to-weight-loss-and-muscle-supplements/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/02/03/hawaii-seeks-to-restrict-access-to-weight-loss-and-muscle-supplements/\">Hawaii</a>, <a href=\"https://www.nutraingredients.com/Article/2026/01/15/alaskan-legislator-proposes-restrictive-supplements-bill/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/01/15/alaskan-legislator-proposes-restrictive-supplements-bill/\">Alaska</a>, <a href=\"https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202520260AB2030\" target=\"_blank\" rel=\"\" title=\"https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=202520260AB2030\">California</a>, <a href=\"https://www.nutraingredients.com/Article/2026/03/12/rhode-island-bill-proposes-age-restrictions-on-weight-loss-and-muscle-building-supplements/\" target=\"_blank\" rel=\"\">Rhode Island</a>, and <a href=\"https://www.cga.ct.gov/asp/cgabillstatus/cgabillstatus.asp?selBillType=Bill&bill_num=SB00227&which_year=2026\" target=\"_blank\" rel=\"\" title=\"https://www.cga.ct.gov/asp/cgabillstatus/cgabillstatus.asp?selBillType=Bill&bill_num=SB00227&which_year=2026\">Connecticut</a>, that would place age restrictions on certain supplement purchases and retail access."},{"_id":"KVI4FJXIYJCQVKUJASOXB7QQGU","additional_properties":{},"type":"text","content":"Many of these bills reportedly originate from the Strategic Training Initiative for the Prevention of Eating Disorders (STRIPED), which launched as a âpublic health incubatorâ based at the Harvard T.H. Chan School of Public Health and Boston Childrenâs Hospital."},{"_id":"KVEHSHEZFJGNBCUKDJUFZEBI6I","additional_properties":{},"type":"text","content":"Proponents of the restrictions cite a purported link between the use of such products and the worsening of eating disorders, even though <a href=\"https://doi.org/10.3390/nu15092076\" target=\"_blank\" rel=\"\" title=\"https://doi.org/10.3390/nu15092076\">a review of the scientific literature</a>
2039, funded by the Council for Responsible Nutrition, concluded that the âevidence to date does not support a causative role for dietary supplements in eating disorders."},{"_id":"6R6FT3FJXJAEZIHOZXE6M2AQEE","additional_properties":{},"type":"text","content":"âThe use of dietary supplements for weight management in both male and female teens appears to be declining, and the objective of weight loss is not observed as a common motivation for the use of dietary supplements among this age group,â wrote Susan Hewlings, PhD, RD, the author of the review, which was published in the journal <i>Nutrients</i>."},{"level":2,"_id":"5OVIIYTW5RGZTODUF6DAH5AEUE","additional_properties":{},"type":"header","content":"Federal preemption efforts"},{"_id":"RDHZKVV3LVE73HYZ7H65W34CPI","additional_properties":{},"type":"text","content":"In February, Rep. Nick Langworthy (R-NY) introduced <a href=\"https://www.congress.gov/bill/119th-congress/house-bill/7366/text?s=1&r=1&hl=hr7366\" target=\"_blank\" rel=\"\">H.R. 7366</a> in the U.S. House of Representatives to amend the Federal Food, Drug, and Cosmetic Act to clarify that the States cannot establish or continue any dietary supplement-related requirements that are different from the federal law."},{"_id":"ZBOR3KNEJNBNJEWGWT42GDP3SA","additional_properties":{},"type":"text","content":"The bill specifically aims to clarify federal preemption so that supplements meeting FDA requirements are not subjected to a patchwork of laws at the state level. To date, Langworthyâs home state of New York is the only place to pass a restrictive bill. "},{"_id":"KDZD47QVFFACPJN4HGSGTXNPU4","additional_properties":{},"type":"text","content":"âWhen states override science-based FDA determination, you end up in a situation where the same product is treated as safe in one state, but suspect in another state, just by crossing a state line,â stated Langworthy during an April 29 hearing titled Healthier America: Legislative Proposals on the Regulation and Oversight of Food. âThatâs regulation for regulationâs sake; it doesnât make any sense for businesses or the people that they serve. Thatâs why I have introduced H.R. 7366, the Dietary Supplement Regulatory Uniformity Act, to reaffirm that we should have one clear, science-based national standardânot a patchwork of conflicting state rules.â"},{"_id":"NWAZPUH3HBBCHDNHTPHPDIQGNA","additional_properties":{},"type":"text","content":"Despite vocal support from industry stakeholders, <a href=\"https://www.congress.gov/bill/119th-congress/house-bill/7366/text?s=1&r=1&hl=hr7366\" target=\"_blank\" rel=\"\">H.R. 7366</a> is unlikely to advance during this Congress, said Dr. Daniel Fabricant, NPAâs president and CEO. "},{"_id":"DKIZSMFZ5NBFLDRUYKBCF6NE6Y","additional_properties":{},"type":"text","content":"âItâs really important to keep pushing back on these state bills,â said Dr. Fabricant. âWeâve seen efforts in twenty-plus states now. What is going to take for industry to stand up to these?â"}],"subheadlines":{"basic":"A lawmaker in New Jersey has filed a bill to prohibit the sale of weight loss and muscle building products to minors, part of a broader trend of state-level efforts to restrict youth access to certain dietary supplements. "},"description":{"basic":"A New Jersey legislator has introduced Assembly Bill A5487 to prohibit the sale of certain weight loss and muscle building supplements, including those containing creatine and green tea extract, to minors, requiring age verification and imposing fines for violations. This measure is part of a broader trend of state-level proposals, many linked to the STRIPED initiative, aiming to restrict youth access to specific supplements, despite industry pushback and mixed scientific evidence regarding their link to eating disorders. Federal efforts, such as H.R. 7366, seek to prevent states from enacting stricter laws than federal regulations, but progress remains uncertain. 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"},{"_id":"IB2P6L5DWFAYLINCCXP352EXWM","additional_properties":{},"type":"text","content":"Exporters will also be exempt from New Zealandâs compositional requirements for food additives and maximum daily dose of vitamins and minerals. Currently, dietary supplement exporters must comply with both New Zealandâs labeling and composition requirements and those of countries to which they export. This is the case even if the products are not intended for sale in New Zealand. "},{"_id":"OCG6SRDOBVAFFGT3354JDAWZOU","additional_properties":{},"type":"text","content":"Hoggard explained that the current regulatory regime, which restricts product composition and prohibits therapeutic claims, limits the flexibility of New Zealand exports to compete in international markets, resulting in âlost commercial opportunities.â "},{"_id":"WE5V7CNXRNCN7DBHTSUXPV6WR4","additional_properties":{},"type":"text","content":"âThe changes would prevent unnecessary double-up by requiring exporters to only meet the rules of the importing country,â he stated. âItâs a common-sense change strongly supported by industry and would help to level the playing field for a rapidly growing industry, without compromising on consumer safety.â"},{"_id":"CFFHOIW6GFGZRH3J7WBKBPQOE4","additional_properties":{},"type":"text","content":"If implemented, the proposal would mean that dietary supplements complying only with the regulations of importing countries cout not be sold in New Zealand. "},{"_id":"4SGUQNN4ARHQTG2BSJMXXPIPCQ","additional_properties":{},"type":"text","content":"Commenting on the proposal, industry association Natural Health Products NZ (NHPNZ) Government Affairs Director Samantha Gray welcomed the move, highlighting that exporters can tap into opportunities in fast-growing markets, since it would allow businesses to tailor export-only products to international rules and market-driven demands. "},{"_id":"WI7FGLGBCBEWXB5JYMAURWW5BU","additional_properties":{},"type":"text","content":"âThis will be a game changer for our industry,â Gray said. âWithout a doubt, this will free up exporters from decades of red tape, saving time and money. It means New Zealand businessesâranging from innovative startups and SMEs to large enterprisesâcan better tap into fast-growing markets across Asia, the Middle East, North America and Europe.â"},{"level":2,"_id":"2DN2GOAIVBDBXGMFDTXMFYFSSE","additional_properties":{},"type":"header","content":"NZ$500M in additional export opportunities "},{"_id":"GWLTGWEL6FGDNFO4RR3QH2DHE4","additional_properties":{},"type":"text","content":"The reforms are projected to unlock up to NZ$500 million (US$283.5 million) a year in additional export opportunities, according to NHPNZ. The industry is currently worth about NZ$2.3 billion (US$1.3 billion) annually. "},{"_id":"CITGXQFWD5HOHF7ZKFZ7MRWC6Y","additional_properties":{},"type":"text","content":"The trade association highlighted a series of engagements with the government in the lead-up to Hoggardâs proposal. "},{"_id":"HYWOP5Z7BRAJ5HHEF7RNNMGXTA","additional_properties":{},"type":"text","content":"One such engagement involved demonstrating to Trade Minister Todd McClay how New Zealand brands have been excluded from Chemist Warehouseâs expansion into Dubai because export exemptions were unavailable. Chemist Warehouse has since opened four outlets in the UAE, the latest of which is located in Abu Dhabi Mall. "},{"_id":"T5ZZIP5SORB7ZOOLYQ7TBYLA2M","additional_properties":{},"type":"text","content":"It also developed a global market analysis comparing the natural health products sector with key trading partners and New Zealandâs wine and honey industries. "},{"_id":"2F6PTXWE35E5BPXXGN7DV3DZLU","additional_properties":{},"type":"text","content":"âThis work has helped position the sector as a growth opportunity and strengthened our engagement with the Ministry of Primary Industries (MPI) on its growth strategy,â NHPNZ shared in its response to Hoggardâs proposal. "},{"level":2,"_id":"P6NPV2LQCRH2VLTCHLCGIZ7L2M","additional_properties":{},"type":"header","content":"A first step, not the finish line"},{"_id":"T5EQYUT5Q5HEFLZOXVFTJLCCQM","additional_properties":{},"type":"text","content":"While expressing optimism about the proposal, Gray said it is crucial that the regulations are implemented effectively, without further delay. "},{"_id":"FIDVVH67UNF6RMYLMCRPVKJXOY","additional_properties":{},"type":"text","content":"She explained that, ultimately, exporters would need a clear, workable pathway covering the full range of dietary supplements to realized the benefits of the proposed regulatory change. "},{"_id":"FJY7IK3NMBCR3NE5XHOHNV7T3Q","additional_properties":{},"type":"text","content":"âA lack of regulatory reform over many years has left us lagging behind international trading partners,â she said. âThe fact that our sector has grown to its current scale is a credit to the people backing it. 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2039,{"_id":"3736LJXI4ZFMLIRGZMIMHLWN2E","additional_properties":{},"type":"text","content":"The complaint also alleged that Amway, WWG and LTD deceptively instructed IBOs to falsely report selling products that they, in fact, did not sell, to create the appearance that the Amway opportunity revolves around selling products rather than attempting to recruit new IBOs to purchase Amway products. "},{"_id":"QZN6P4ZJTRABRO3N5OA2K4DJYU","additional_properties":{},"type":"text","content":"âAmway and its affiliates misled prospective workers with false earnings claims and then pressured them to buy Amway products they were unlikely to be able to sell,â stated Christopher Mufarrige, director of the FTCâs Bureau of Consumer Protection, in a press release. â[This] action makes clear that the FTC will not tolerate any company deceiving workersâwhether through deceptive earnings claims or by promoting reports of false sales to make direct selling or multilevel marketing opportunities look appealing to consumers.â"},{"_id":"LJQHWAUSPRH5HCEMFMISAKDZ2A","additional_properties":{},"type":"text","content":"The two Amway licensees were also accused of selling training materials to IBOs that were allegedly marketed as being essential for success. However, according to the FTC and Washingtonâs joint complaint, the trainings were claimed to instruct IBOs to buy a set quantity of products every month regardless of whether they could be resold, and to focus their time on trying to recruit others to duplicate that behavior. "},{"level":2,"_id":"L66RHSJ2OBHIDEHHGFYMGHZSOU","additional_properties":{},"type":"header","content":"âCompromiseâ"},{"_id":"TG3KSVMNDJCQRFE3FYML2O72VU","additional_properties":{},"type":"text","content":"In a statement on its website, Amway said it fundamentally disagrees with the FTCâs and the state of Washingtonâs characterization of its business. "},{"_id":"IHN2T3KNPRDH7IXG5I64CYPZX4","additional_properties":{},"type":"text","content":"âAs part of their contract with Amway, all Independent Business Owners (IBOs) must follow robust standards of conduct. Amway rejects the agenciesâ assertion that the companyâs sales data is not accurate. In fact, Amway and the FTC have agreed to rely on our sales data to continue tracking and substantiating IBO customer sales,â stated the company. "},{"_id":"M34SOV3UE5BV5PKLDC6RGGSPPE","additional_properties":{},"type":"text","content":"âThis settlement, like all settlements, required compromise. Resolution positions us to move forward and focus our energy where it belongs: on our customers, IBOs and employees.â"},{"level":2,"_id":"6VAQ35CX7RCJ7GX2J5DGH3GYFY","additional_properties":{},"type":"header","content":"Details of the settlement"},{"_id":"WR2JOPUQ4BEABL4KQLVGLJL7UI","additional_properties":{},"type":"text","content":"The proposed order settling the FTC and Washingtonâs allegations imposes a $225 million judgment, the majority of which will go to IBOs recruited by WWG and LTD who lost money. "},{"_id":"XUADQ7KJ2JFGPBMQWHB5MGAXM4","additional_properties":{},"type":"text","content":"In addition, Amway, WWG and LTD agreed to change their practices, including: IBOs will be required to sell to others at least 70% of the products they purchase from Amway each month; reduced compensation for recruiters if the IBOs they recruit buy products but do not resell them; terminate IBOs who fake sales or teach others to do so; required training for IBOs on these new rules; and regular auditing of Amwayâs sales records by an independent outside auditor."},{"_id":"QCWIZD2ZEFCNPGDM5EHUB45EAA","additional_properties":{},"type":"text","content":"More details can be found <a href=\"https://www.ftc.gov/system/files/ftc_gov/pdf/Amway-StipulatedOrder.pdf?_sp=dbcd4278-afd5-4c26-b8ca-b54d98483e5c.1790114382894\" target=\"_blank\" rel=\"\"><b>HERE</b></a>. "}],"subheadlines":{"basic":"Multilevel marketing giant Amway and two Amway licensees will pay $225 million to resolve allegations from the Federal Trade Commission and the state of Washington for alleged unfair and deceptive tactics."},"description":{"basic":"Amway and two affiliates have agreed to pay $225 million to settle allegations from the FTC and the state of Washington of using deceptive and unfair tactics, including misleading earnings claims and pressuring recruits to buy products unlikely to be resold. The settlement, the largest ever against a multilevel marketing company, will compensate affected Independent Business Owners (IBOs) and requires Amway to implement reforms such as stricter sales requirements, reduced re
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beets and other nitrate-rich vegetables may provide benefits as a natural performance enhancerâand in athletes, some of that reputation is deservedâthe leap from better exercise performance to treating hypertension is not supported by the biology or by the evidence."},{"_id":"ZAQNY6TRZ5C3VIE6J7CQHBHUNQ","additional_properties":{}
2039,"type":"text","content":"The confusion begins with nitrate, a compound found in beets and other vegetables that can enter the bodyâs nitric oxide pathways. Nitric oxide is central to vascular biology, which makes the story sound simple: More dietary nitrate, more nitric oxide, lower blood pressure. "},{"_id":"7E7UJF733VDDDLA6BKP4AEGM6M","additional_properties":{},"type":"text","content":"The actual physiology is far more constrained. The benefits seen in exercise arise under specific local conditions in working muscle; they do not translate into a reliable systemic treatment for hypertension."},{"_id":"EZJAKEHHEJC2DEZXV4CJOZ3MOE","additional_properties":{},"type":"text","content":"The legitimate evidence begins in sports physiology."},{"level":2,"_id":"BVLGPCZT4FACFJ5E6QXMKEM6LQ","additional_properties":{},"type":"header","content":"Beets and beet juice for sports performance "},{"_id":"XBDMWJIRDRFMNJ5PZUMG2XUAW4","additional_properties":{},"type":"text","content":"<a href=\"https://doi.org/10.1152/japplphysiol.00372.2013\" target=\"_blank\" rel=\"\" title=\"https://doi.org/10.1152/japplphysiol.00372.2013\">Research initiated</a> by groups in the UK and Scandinavia has found that beets or beet juice can improve cardiovascular performance in sports, particularly in activities with intense aerobic demands, such as cycling, <a href=\"https://doi.org/10.3390/nu6020605\" target=\"_blank\" rel=\"\">swimming</a> and distance running."},{"_id":"DXSRXXX34FFF7LE3E2QVTHQ3DM","additional_properties":{},"type":"text","content":"Researchers identified organic nitrate in beets as the biochemical driver behind these benefits, but the findings are not universal. In one study of individuals with chronic obstructive pulmonary disease, a four-fold increase in plasma nitrate <a href=\"https://www.sciencedirect.com/science/article/abs/pii/S1089860315000038\" target=\"_blank\" rel=\"\">had no effect on blood pressure or performance.</a>"},{"_id":"BGMGOFKR45HKZN4HQI6HUA7YXI","additional_properties":{},"type":"text","content":"Exceptions to the rule are always insightful. "},{"_id":"VBKHAWHZS5FQXMJNJHGIWOJ6JY","additional_properties":{},"type":"text","content":"Natural product approaches to enhanced sports performance attract attention. The central question, however, is how nitrate produces these effects. The proposed mechanism involves a series of reduction steps: Nitrate is converted to nitrite, and nitrite is then converted to nitric oxide."},{"_id":"OYIDVDKRYRFAXOFBXRBSGQIBII","additional_properties":{},"type":"text","content":"Nitric oxide has been the focus of intense research since scientists discovered that it is generated from the amino acid L-arginine through three distinct enzymes known as nitric oxide synthases. That work helped lead to the <a href=\"https://www.nobelprize.org/prizes/medicine/1998/summary/\" target=\"_blank\" rel=\"\">1998 Nobel Prize in Physiology or Medicine</a> for the discovery that nitric oxide acts as a signaling molecule in the cardiovascular system. Long before the beet-juice debate, nitric oxide-delivering drugs were known to lower blood pressure because of their vasodilator properties. They do this by activating guanylate cyclase and elevating cGMP. It was not until the 1980s, however, that our research identified a lack of nitric oxide as a key driver of high blood pressure <a href=\"https://www.ahajournals.org/doi/10.1161/01.HYP.10.2.164\" target=\"_blank\" rel=\"\">endothelial nitric oxide and hypertension</a>."},{"_id":"Z3TFL5AEGBCETG5OF2ILQU2W4I","additional_properties":{},"type":"text","content":"That history makes enthusiasm for natural ways to raise vascular nitric oxide understandable. The problem is that the nitrate-nitrite-nitric oxide pathway operates independently of nitric oxide synthase, and its effects appear to be highly context-dependent."},{"_id":"WE3P6DBO5FDPTAJP5MZB7BHMYY","additional_properties":{},"type":"text","content":"The initial conversion of nitrate to nitrite is driven by nitrate reductase enzymes in specific bacteria in saliva. The next stepâthe conversion of nitrite to nitric oxideâcan occur under acidic conditions or through hypoxia-induced activation of xanthine oxidase. Those conditions are most likely to occur locally, in hard-working muscle, not systemically throughout the circulation."},{"_id":"5LNIBRIFE5G63EC7B6NVGV7XXE","additional_properties":{},"type":"text","content":"In extreme aerobic exercise, such as competitive cycling or marathon running, working muscles can create the low pH and relative ischemia needed to convert nitrite to nitric oxide. The likely result is a localized increase in blood flow that helps deliver oxygen and nutrients while removing metabolic byproducts such as lactic acid."},{"_id":"2E3SJ6X4EJABDL4REANFYGVKHA","additional_properties":{},"type":"text","content":"My research team tested whether this scenario was limited to aerobic exercise. <a href=\"https://doi.org/10.1080/07315724.2015.1081572\" target=\"_blank\" rel=\"\">In a strength-training study</a>, a bar product combining beets with antioxidants improved performance and muscle recruitment. Importantly, however, these benefits occurred without changes in blood pressure."},{"_id":"W7EBWCOEP5CQHNAKPYPO3X3TSE","additional_properties":{},"type":"text","content":"The lesson is that hard-working muscles can tap the nitrogen cycle to generate nitric oxide locally, but that does not mean beets produce a meaningful systemic effect on blood pressure. In the presence of hemoglobin, nitric oxide <a href=\"https://doi.org/10.1074/jbc.273.30.18709\" target=\"_blank\" rel=\"\">has a half-life of milliseconds before it is rapidly oxidized back to nitrate.</a> The effect is localized and mild, not body wide and sustained."},{"_id":"NJLYMW2UXZFFRJ2BKVWTYVVS7A","additional_properties":{},"type":"text","content":"That distinction matters. Some aerobic exercise studies show small reductions in systolic blood pressure, often around 2 to 4 mmHg, while others show no effect. <a href=\"https://doi.org/10.1016/j.numecd.2024.06.009\" target=\"_blank\" rel=\"\">A large meta-analysis of beet or beet-juice interventions</a> found a small effect on systolic blood pressure, but no effect on diastolic pressure, mean arterial pressure or 24-hour blood pressure measurements. The authors concluded: âThere is no evidence for a prolonged 24-h BP-reducing effect. Certainty of evidence is low.â"},{"_id":"L4Z5O2ZEOJBOJH7R7YCM725A74","additional_properties":{},"type":"text","content":"For sports performance, the nitrate story has value. For hypertension, it is often taken out of context."},{"level":2,"_id":"WPDNMO26FRHLZPUD7QR2CD2ZHM","additional_properties":{},"type":"header","content":"Nitric oxide and the circulation"},{"_id":"6KW5YUQMMFA5ZDIOZ6I7QJNJBU","additional_properties":{},"type":"text","content":"Beyond the issues with the accuracy of measuring blood pressure (systolic, diastolic and mean) we need to better place perspective on how nitric oxide works and where? Nitric oxide production in blood vessels has a half-life of a few milliseconds, as <a href=\"https://www.jbc.org/article/S0021-9258(18)80192-2/fulltext\" target=\"_blank\" rel=\"\" title=\"https://www.jbc.org/article/S0021-9258(18)80192-2/fulltext\">my team defined with a unique electrochemical probe</a>. Basically, all nitric oxide actions are local, and when it interacts with hemoglobin it is rapidly oxidized to nitrate and other reactive nitrogen species before it can circulate like a hormone. The furthest it can reach from sites of production is a few cells, certainly not like a circulating hormone. "},{"_id":"ATII6CHS7BFWHOJNA4UYST3XQI","additional_properties":{},"type":"text","content":"For increased nitric oxide production to lower blood pressure, one needs a substantially greater production of nitric oxide and it needs to be systemic, i.e., throughout the body and not just a working muscle. There can be a role for nitric oxide in controlling vascular resistance but also in septic shock. In the latter, excessive production of nitric oxide, activated by bacterial infections, greatly reduces vascular tone and limits organ perfusion as a result of the substantially reduced blood pressure. <a href=\"https://pubmed.ncbi.nlm.nih.gov/7714773/\" target=\"_blank\" rel=\"\">My research team showed</a> that capturing excess NO with vitamin B12 (via its bonding with the cobalt atom) could sequester excess nitric oxide and limit organ failure and mortality in sepsis. "},{"_id":"FE3NZY2EXJF45J4LELPRMDAISM","additional_properties":{},"type":"text","content":"From this it is clear that nitric oxide plays an important role in circulatory function, as seen with examples of excess and inadequacy."},{"level":2,"_id":"DRZPY5ABNZFEHIXGLU4MZMQ2HY","additional_properties":{},"type":"header","content":"Vascular resistance and systolic vs. diastolic blood pressure"},{"_id":"U5NF3RXBQRGILIKPNP3WGURVGI","additional_properties":{},"type":"text","content":"The other concept that needs to be accounted for, is that as a vasodilator, nitric oxide would primarily influence blood pressure by lowering vascular resistance, as opposed to cardiac output. "},{"_id":"VXBY5F6WK5HJNF5GUUSQAFTMYQ","additional_properties":{},"type":"text","content":"When we measure diastolic blood pressure, we are getting a window into the arterial resistance of the cardiovascular system because it is independent of the heart contractions. Conversely, systolic blood pressure reflects when the heart contracts and that impact is layered on top of overall systemic vascular resistance. "},{"_id":"ACJ6X6YCBJBYDM2CMFJ6CVI7EA","additional_properties":{},"type":"text","content":"When an intervention, like beets, does not alter diastolic (or mean) arterial pressure then there one can safely assume that vascular resistance is not altered. In other words, there is no evidence that ingestion of nitrate rich beets promotes systemic vasodilation. "},{"_id":"37SXUKRUKBFCBJWAGWOTS35VYU","additional_properties":{},"type":"text","content":"If nitric oxide was being produced systemically in amounts that cause widespread vasodilation, then diastolic blood pressure would fall. It doesnât in any of these studies with beets. "},{"level":2,"_id":"A7OWQZBC35GAFLOPCZFXQZKWZQ","additional_properties":{},"type":"header","content":"Food vs. supplements vs. drugs"},{"_id":"GQ27CIOSANE47HWCGSOTO7C7ZA","additional_properties":{},"type":"text","content":"Inherent in the rampant publicity that is associated with beets and blood pressure is the robust enthusiasm to manage a pervasive and critical healthcare issue, hypertension, with dietary driven solutions. "},{"_id":"V7WXLNNVXVBCHKVAAP4W7DYYRI","additional_properties":{},"type":"text","content":"Here there is a passionate abhorrence to using supplements and pharmaceuticals, after all âFood is they Medicineâ. Directed by that passion and amplified by a lack of understanding of the complexities of the biochemistry of nitric oxide and related nitrogen oxides, the impact of this combination is that a false narrative is generated and spread profusely. "},{"_id":"EAW4OB6RABHS5P3VQZO6UVV2IU","additional_properties":{},"type":"text","content":"Historical perspectives are tossed aside as being too confusing. Information like the vasodilators nitroprusside and nitroglycerin, the Nobel Prize for those actions and the nitric oxide generation from L-arginine, and the massive amount of research on nitric oxide in general, are not included as they are not food generated."},{"_id":"HPWUT4DUGVGZBJHDKIA67DNULY","type":"divider"},{"_id":"HZX6OHD7D5B4RFWDCQOUUJADXU","additional_properties":{},"type":"text","content":"<i>Dr. Mark JS Miller has extensive experience in entrepreneurship, M&A, manufacturing, R&D, marketing and brand building within the natural products industry. Prior to that transition he was a tenured professor of pharmacology, pediatrics and cardiovascular edicine in three different US-based medical schools. </i>"},{"_id":"VQ3A4RHGPVE4JBMM7CSP4XJE34","additional_properties":{},"type":"text","content":"<i>His contributions to our understanding of nitric oxide and related reactive nitrogen species has defined health and disease across a wide range of disciplines and systems. They include cardiovascular function, inflammation, gastroenterology, cancer, fetal development, neonatal nutrition, sports performance and biochemistry. </i>"}],"subheadlines":{"basic":"An increasingly common mainstream media narrative portrays beets as an effective approach to lowering high blood pressure, but this claim remains unsubstantiated and reflects a misguided understanding of the cardiovascular system and the role of nitric oxide."},"description":{"basic":""},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Research","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Research","description":"","_id":"/News/Research","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News","weekly-newsletter-sections":"/"},"website":"nutraingredients-v2","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"navigation":{"nav_title":"Research","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Research"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Research","_id":"/News/Research","ancestors":{"weekly-newsletter-sections":["/"]},"order":{"default":3,"main-navigation":3,"weekly-newsletter-sections":1001}}},"_website_section_id":"nutraingredients-v2./News/Research","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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Born in Iran during the eight-year long Iran-Iraq War, she witnessed the quieter consequences of war firsthand, including undernutrition among vulnerable populations. That experience inspired her to study nutrition, become a registered dietician and earn a PhD in nutritional sciences. "},{"_id":"6GYOKN57UJFSHMZ4NJMK7QYQ5Q","additional_properties":{},"type":"text","content":"Fast forward to today, Sharafi uses an elevator analogy to describe her approach to leadership. âYou are in an elevator. You keep the door open. You help women get in. But whatâs better is asking them which floor you want to go [to],â she said."},{"_id":"R3OZ2ENDF5A4RCNQS4LPKPVZLU","additional_properties":{},"type":"text","content":"Rather than choosing the destination for them, Sharafi said leaders should ask women about their aspirations, goals and passions, then tap their resources, access and knowledge to help them get there."},{"_id":"2G4GRX3I2BEZLJOKVLX7HJ5EAY","additional_properties":{},"type":"text","content":"She also drew a distinction between mentorship and sponsorship."},{"_id":"H5Z4HSGXIJB23CYHF7TW363Z7E","additional_properties":{},"type":"text","content":"âA mentor is someone who guides you, shows you the way,â she said. âBut a sponsor is someone that uses their influence to and advocates for you â even if youâre not in the same room.â"},{"_id":"JUH5QGJBPZHFNH7LNPFZC5WTNM","additional_properties":{},"type":"text","content":"That advocacy can mean telling others that a woman is ready for a role, should lead a project or be included in an important meeting."},{"_id":"U7S24CCVSRCBTPTYA52QJIJA5Y","additional_properties":{},"type":"text","content":"Sharafi also noted that effective leadership sometimes means stepping aside and letting another woman âtake charge, give the presentation, take the spotlight.â"},{"_id":"UNPKJNPAGVGGZOK7MUXAXYVRKA","additional_properties":{},"type":"text","content":"Ultimately, she said success isnât about seeing one woman of color at the top. 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The last edition of the survey was published a year ago, but the public debate has remained remarkably muted. This is difficult to understand. Figures of this magnitude warrant serious debate."},{"level":2,"_id":"TL47YCSVRJA6HL42WXSC6DQ3U4","additional_properties":{},"type":"header","content":"Not an abstract problem"},{"_id":"2GKFT5GCKVDITFAWNDLTBKAPPY","additional_properties":{},"type":"text","content":"Let us begin with the fundamentals: A healthy and varied diet is the first line of defense for our health. There is no dis
2039pute about this. Yet this foundation is particularly fragile in our country. The figures are clear: Our dietary habits fall short on a large scale."},{"_id":"YVCJQ37L2RHY5MDYBBIUJLLFFI","additional_properties":{},"type":"text","content":"The consequence? A large majority of Belgians are at risk of vitamin and mineral deficiencies. For folate, this concerns 70% of the population; for calcium, 67%; for riboflavin, 63%; and for vitamin C, 61%. Then there is vitamin D: 95% do not meet the recommended intake of 15 µg per day."},{"_id":"WAUBC2OHPNEMRKFW2E3RIFR3CI","additional_properties":{},"type":"text","content":"Moreover, the risks are not evenly distributed. Women, adolescents and people with lower levels of education are particularly vulnerable. Among adolescents, 86% have an insufficient calcium intake; among adolescent girls, 43% have an intake below their iron requirement."},{"_id":"HK4VN2FN3ZGHBC67PB2ZZNL2JQ","additional_properties":{},"type":"text","content":"Those who read these merely as percentages overlook what is truly at stake. These figures affect people in their daily lives. At the same time, at the societal level, they contribute to healthcare costs that are already exceptionally high."},{"_id":"RAVVKEPXLNHXHHCP7SZASOYVNI","type":"raw_html","content":"<iframe title=\"Shortfalls of key nutrients in Belgian population\" aria-label=\"Table\" id=\"datawrapper-chart-NYSu6\" src=\"https://datawrapper.dwcdn.net/NYSu6/1/\" scrolling=\"no\" frameborder=\"0\" style=\"width: 0; min-width: 100% !important; border: none;\" height=\"553\" data-external=\"1\"></iframe>
2039<script type=\"text/javascript\">(function(){function e(){window.addEventListener(`message`,function(e){if(e.data[`datawrapper-height`]!==void 0){var t=document.querySelectorAll(`iframe`);for(var n in e.data[`datawrapper-height`])for(var r=0,i;i=t[r];r++)if(i.contentWindow===e.source){var a=e.data[`datawrapper-height`][n]+`px`;i.style.height=a}}})}e()})();<\/script>"},{"level":2,"_id":"J47LPOCKUZG77BRML2DY6GTP4U","additional_properties":{},"type":"header","content":"Not a snapshot, but a worsening and general trend"},{"_id":"2EQYBJSLHFHPDO7HPLKLEZISH4","additional_properties":{},"type":"text","content":"Anyone hoping that this is merely a snapshot will be disappointed. Compared with the 2014â2015 survey, the average intake of vitamin C, vitamin A, riboflavin and calcium, among others, has declined further. The trend is not moving in the right direction. Quite the contrary. "},{"_id":"OEZBUIBL5VFDFEKSJYUBFHDSP4","additional_properties":{},"type":"text","content":"Belgium is not alone in this regard. In the Netherlands and France, we also observe inadequate intakes of the same nutrients, largely among the same groups. This is therefore not a Belgian anomaly but a structural pattern across Western Europe. That does not make the problem any less serious. It only makes the need for a serious debate more urgent."},{"level":2,"_id":"7PXXA2OWPNBQNNVJZGMG7M7V5M","additional_properties":{},"type":"header","content":"Healthy nutrition first. But with an open mind."},{"_id":"LECTTUDVMZFYHIDBIJA3DEPS5E","additional_properties":{},"type":"text","content":"How can we reverse this trend? One principle is beyond question for me: Healthy nutrition must always come first. Every effort to help Belgians adopt healthier diets deserves support. A food supplement is not a substitute for a healthy and varied diet. Full stop."},{"_id":"6EGWXJRUPZDFVEP4HUSOG56BZU","additional_properties":{},"type":"text","content":"But this must not become an excuse for failing to confront the figures. The reality is what it is, and we must act on it. Where diets fall short, targeted food supplementation, where necessary and based on professional advice, can play an important complementary role, for example in relation to vitamin D and folic acid."},{"_id":"QU7ENCDMPRG3BPZGG6FC2DGACI","additional_properties":{},"type":"text","content":"This is therefore my appeal: Let us not file these figures away once again. Let us continue the debate among scientists, policymakers, healthcare professionals and the sector, with an open mind but based solely on the facts and with one shared objective: to strengthen the health of our citizens."},{"_id":"ON4OWTJS45BDXCRYDUVXOXHLWU","additional_properties":{},"type":"text","content":"The figures are clear. The task now is to take them seriously."},{"_id":"C4GIDDFHZ5HGHE7HODGUPGOMMI","type":"divider"},{"_id":"2TTSFDVBNVFBDMVZUOHHI7IO2Q","additional_properties":{},"type":"text","content":"<i>Valerie Vercammen is managing director of be-sup, the official trade association representing the food supplement industry in Belgium.</i>"}],"subheadlines":{"basic":"Only 7% of adults consume enough vegetables. Barely 1% meet the recommendation for whole grain products. These are not footnotes in an extensive report. They are alarming signals concerning the health of the Belgian population. "},"description":{"basic":"In this guest article, Valerie Vercammen, managing director of Be-Sup, the professional association representing the food supplement industry in Belgium, appeals to scientists, policymakers, healthcare professionals and the sector to consider the latest results of Belgium's National Food Consumption Survey, which she emphasizes present \"alarming signals concerning the health of the country's population."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Opinion","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Opinion","description":"","_id":"/News/Opinion","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"website":"nutraingredients-v2","navigation":{"nav_title":"Opinion","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Opinion"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Opinion","_id":"/News/Opinion","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"order":{"default":6,"main-navigation":6}}},"_website_section_id":"nutraingredients-v2./News/Opinion","type":"section","version":"0.6.0"},{"path":"/Resources","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Resources","description":"","_id":"/Resources","additional_properties":{"original":{"parent":{"
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authors from the Egas Moniz Center for Interdisciplinary Research, Portugal, noted that One Health will remain largely aspirational unless its principles are translated into everyday practice by health professionals and embedded in education, professional identities and health-system structures."},{"_id":"VLYIYKIPTFBF7DSU6HD4AQFPSA","additional_properties":{},"type":"text","content":"One Health recognizes that human, animal and ecosystem health are interconnected. The researchers argue that nutrition professionals are particularly well placed to put this approach into practice because they operate at the intersection of food, human behaviour, population health and environmental sustainability."},{"_id":"A6KJWPRXGFBTTDSUKYARQEPKFI","additional_properties":{},"type":"text","content":"âResponding to this complexity requires the coordinated mobilization of all health professionals,â they wrote in the perspective article."},{"level":2,"_id":"CTVIQZBCQZFSLMIACG73OW5WUU","additional_properties":{},"type":"header","content":"From individual diets to wider food systems"},{"_id":"RIE3XMTEYJDVTEMF7S6GBLTZXM","additional_properties":{},"type":"text","content":"Nutrition is increasingly recognized as <a href=\"https://www.sciencedirect.com/science/article/pii/S2666606523001608\" target=\"_blank\" rel=\"\" title=\"https://www.sciencedirect.com/science/article/pii/S2666606523001608\">more than a matter of individual dietary choice</a>. Dietary patterns, physical activity, environmental exposures, socioeconomic circumstances and access to healthy food can all influence the risk of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, cancer and digestive disorders."},{"_id":"VJAW4TTPT5HMNNHQ7I2BDSXNSY","additional_properties":{},"type":"text","content":"These factors are also <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC10972712/\" target=\"_blank\" rel=\"\" title=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC10972712/\">closely connected</a>. Socioeconomic inequality, for example, can limit access to nutritious food and opportunities for physical activity, while environmental change can disrupt food availability and increase exposure to health risks."},{"_id":"4VCJFO74RZEQ7OZXZT6QBAO3DU","additional_properties":{},"type":"text","content":"For the researchers, this makes nutrition a strategic entry point for tackling several challenges simultaneously."},{"_id":"NFR25TCXC5HTDG4GHJ5SXTF474","additional_properties":{},"type":"text","content":"A One Health approach could see dietitians supp
2039orting healthier eating patterns while also considering the economic, social and environmental conditions that influence what people eat. At community and population level, nutrition professionals can contribute to tackling food insecurity and improving food environments across schools, workplaces and public health programs."},{"_id":"4WEP6MOE3RHPDAMG72CQU53AIM","additional_properties":{},"type":"text","content":"âDietitians are not merely participants in One Health initiatives but can also act as strategic leaders in developing and implementing integrated solutions that connect nutrition, population health and sustainable food systems,â the authors wrote. "},{"level":2,"_id":"4QA52RKA2FFLLC4476PCJAKDCQ","additional_properties":{},"type":"header","content":"An opportunity for the nutrition industry"},{"_id":"ZP6ZAHJWIJFE7O3HYMGFER5GWY","additional_properties":{},"type":"text","content":"The implications extend beyond clinical practice, with the authors highlighting the potential for dietitians to translate broad sustainability and health principles into practical dietary recommendations, public health programs, food policies and sustainable food strategies."},{"_id":"B5P6HU4QRFGQRBWN7VEMSFFUBA","additional_properties":{},"type":"text","content":"âBy shaping how food is produced, accessed, chosen and consumed, dietitians contribute simultaneously to human health, animal welfare and ecosystem resilience,â they note."},{"_id":"PVHUQRKUDZAVROTMW4F7FBKWIM","additional_properties":{},"type":"text","content":"This creates an opportunity for the nutrition sector to think beyond individual products and ingredients and consider their role within wider food systemsâfrom sourcing and production through to consumer behaviour and health outcomes."},{"_id":"63GFDJHKJRAWVEJ5QYWXYBXTTE","additional_properties":{},"type":"text","content":"However, Fernandes et al. warn that putting One Health into practice will require a fundamental rethink of professional roles and boundaries. Rather than operating in silos, health professionals need to recognize their shared responsibility for addressing the social, economic, environmental and health factors that shape outcomes. "},{"_id":"JA4OIHRX5NECRNMQL2WGEH6QQI","additional_properties":{},"type":"text","content":"âA One Health perspective becomes operationally effective when health systems move beyond rigid role demarcations,â they wrote."},{"level":2,"_id":"HVF3ARC7ZFC2HDRLDZBB2MGWJA","additional_properties":{},"type":"header","content":"Breaking down professional silos"},{"_id":"42YZDRXCYVDR7GFNPGWMJ7YD2I","additional_properties":{},"type":"text","content":"For the nutrition industry, this points towards greater collaboration across healthcare, food production, policy, academia and environmental sectors. "},{"_id":"IMNQ5OQGSNFQDNAJTB3UVYGHLQ","additional_properties":{},"type":"text","content":"Ultimately, nutrition could provide one of the most practical bridges between human health and the systems that sustain it, giving dietitians, and the wider nutrition sector, a potentially pivotal role in turning One Health from a concept into action."},{"_id":"HAVU7VF4BRGR7HHACOE4HQFXOE","additional_properties":{},"type":"text","content":"âBy embedding One Health into nutrition education, interprofessional collaboration, research and evaluation frameworks, dietitians can move from implicit contributors to intentional leaders within One Health agendas,â the authors wrote. "},{"_id":"GGLMK4K7K5EDRDTZVVIP5EKLOA","additional_properties":{},"type":"text","content":"âStrengthening this role is not optional; it is essential to addressing the interconnected challenges of chronic disease, environmental degradation and health inequities in a sustainable, systems-oriented manner.â"},{"_id":"JRNQH2E2FZFVXP4CSCNY2SUJL4","type":"divider"},{"_id":"VGCGGDA37JFGBAGDQQK7S3X7M4","additional_properties":{},"type":"text","content":"Source: <i>Frontiers in Nutrition; </i> doi: <a href=\"https://doi.org/10.3389/fnut.2026.1884842\" target=\"_blank\" rel=\"\">https://doi.org/10.3389/fnut.2026.1884842</a>; âNutrition as a missing link in One Health: from conceptual invisibility to strategic action.â Authors: J. B. 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With some authorities reviewing how the ingredient is defined, there have been calls for clearer specifications and stronger quality frameworks across the category."},{"_id":"6YKGQYB27NG2NEIRQW5X5254R4","additional_properties":{},"type":"text","content":"For manufacturers, suppliers and brands, the outcome could have implications beyond ashwagandha, shaping wider discussions around botanical standards, specifications and quality requirements."},{"_id":"UOUR5X5OKJBM5LXO2N6E3VSUKI","additional_properties":{},"type":"text","content":"To explore these issues, NutraIngredients partnered with Kerry for the recent broadcast <a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\">âAshwagandha: Understanding the Science, Scrutiny and Standards.â</a> The session brought together experts including Dr Thomas Brendler, internationally recognized botanical qual
2039ity specialist and adjunct professor at the University of Illinois Chicago; Petra Erlandson, VP of Sales at Alkemist Labs, a leader in botanical testing; Dr Laura Collins, R&D director of Cognitive Health at Kerry, a global leader in clinically studied functional ingredients; Dr Mark Tallon, food lawyer and managing partner at Legal Products Group; and Jason Watkin, CEO of Canadian wellness brand Purica."},{"level":3,"_id":"GQTYA6NIRBCJPBKQL2WAVR4TNQ","additional_properties":{},"type":"header","content":"Why ashwagandha resonates with consumers"},{"_id":"NVLZAAEDXFHZPGM7DCQ4IPK24I","additional_properties":{},"type":"text","content":"Demand for stressâ and sleepâsupport solutions continues to grow. A recent McKinsey survey found that 55% of US consumers prioritise sleep health, while 53% are focused on stress and anxiety management."},{"_id":"DKR3XX4UYJBZHBXLQ7KUOZY2PM","additional_properties":{},"type":"text","content":"âConsumers are looking for solutions that help them feel more resilient, focused and balanced in their daily lives,â says Dr Laura Collins. âRather than seeking a single benefit, they want products that address multiple interconnected needs. Ashwagandha becomes an ideal solution because it supports both.â"},{"_id":"VN3Z6JGSSZDR3LWUGQOTUB672E","additional_properties":{},"type":"text","content":"This broad appeal has helped the ingredient emerge into mainstream formats Ââ from capsules and functional beverages to beauty products and womenâs health solutions. But rising popularity has also brought heightened regulatory attention."},{"_id":"ZSI7FPFGXRAGROKIA66DQJXGME","additional_properties":{},"type":"text","content":"As the category grows, there is heightened attention on product quality, characterization and evidence. These considerations are becoming increasingly important for maintaining consumer confidence and regulatory trust."},{"level":3,"_id":"4YANPE6X3BCTVPZY4IWBHBB6AQ","additional_properties":{},"type":"header","content":"Regulators raise concerns over safety and consistency"},{"_id":"DDOVH4CUIVDJNNYC7VH3GQSHIM","additional_properties":{},"type":"text","content":"In Europe, Denmark moved to ban ashwagandha in 2023, citing difficulties in establishing safe intake levels. Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all c
2039omes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve communication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
2039ss the key issues shaping the future of the category."},{"_id":"WK4Y3HVPWND4LNWCNBVIALLFNU","additional_properties":{},"type":"text","content":"<a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\"><b>Watch: âAshwagandha: Understanding the Science, Scrutiny and Standardsâ On Demand now to learn about the latest developments in the ashwagandha category.</b></a><b> </b>"}],"subheadlines":{"basic":"A deep dive into the science behind ashwagandha, the regulatory considerations and what the future holds for the category. 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2039its, with implications for healthy aging, metabolic health, and inflammatory balance.</b>"},{"_id":"A5OYF4HX4VG7TJJ7ZQNBEEIS4M","additional_properties":{},"type":"text","content":"Fisetin has never lacked scientific interest. The flavonoid, found naturally in strawberries, apples, and onions, has attracted sustained attention for its antioxidant and anti-inflammatory activity and, more recently, for its senolytic properties: the ability to help clear senescent cells."},{"_id":"266MUNKUSRBAHL3CTW7LDULPHQ","additional_properties":{},"type":"text","content":"What it has lacked is human evidence. Most of the excitement around fisetin has come from cell and animal work, and for an ingredient with commercial ambitions, that gap matters. This year it began to close, with two papers from the 12-week randomised controlled trial in men with obesity, tracking a broad set of inflammatory and metabolic biomarkers at 200 mg/day of fisetin."},{"_id":"CJHFBANIU5HWVLJA3Y6VJAJ44E","additional_properties":{},"type":"text","content":"The results do not make fisetin a treatment for obesity or metabolic disease. Their value to the nutrition industry lies elsewhere: fisetinâs story is moving from cell cultures to measurable human outcomes across more than one dimension of healthy aging."},{"level":3,"_id":"7ABSYPQZCNFZ7AWXXHGQ6YEJTA","additional_properties":{},"type":"header","content":"From senescent cells to human health"},{"_id":"5UH7GQIVHFEQRKOXKI6242AQF4","additional_properties":{},"type":"text","content":"Much of fisetinâs recent reputation rests on cellular senescence. Senescent cells stop dividing but stay metabolically active, releasing signaling molecules that affect the tissue around them. Their accumulation is a central theme in aging biology, and it has made fisetin one of the best-known botanical candidates in the emerging senolytic field."},{"_id":"2GKPJMRI6FALJP2XIW64H2KSOA","additional_properties":{},"type":"text","content":"For supplement brands, the opportunity may extend further. Healthy aging is increasingly treated as a multidimensional target: metabolic resilience, inflammatory balance, physical function, healthspan. Ingredients whose biology plausibly connects to several of those dimensions have an edge, and the 2026 papers put fisetin firmly in that conversation."},{"level":3,"_id":"BI5AKJ33HNCJZMGKZLHIYFIECY","additional_properties":{},"type":"header","content":"What the fisetin human trial found"},{"_id":"AX24UWORKZHYTJAFNZ7YK6ESIY","additional_properties":{},"type":"text","content":"Trialists at Hakim Sabzevari University and collaborating institutions randomized sedentary men with obesity into four arms: fisetin alone (200 mg/day), interval resistance-aerobic training alone, both combined, or placebo, for 12 weeks. Two papers from the clinical trial appeared this year, each covering a different set of biomarkers."},{"_id":"37ZFIUSWSBBZRI5RF4SVZYMCC4","additional_properties":{},"type":"text","content":"The first paper, published in <i>Nutrients</i>, tracked adipokines and lipid-related markers, including asprosin, MCP-1, and adiponectin. The largest changes appeared in the combined fisetin-plus-training arm, with meaningful reductions in asprosin and MCP-1 alongside improved lipid measures; fisetin alone also produced changes on several of these markers, though generally smaller than the combined arm.<sup>1</sup>"},{"_id":"ZHXBX2LMWBFHJBIJPFBHFX44WI","additional_properties":{},"type":"text","content":"The second paper, in the <i>Journal of the International Society of Sports Nutrition</i>, examined a different part of the biology: Maresin-1, a specialised pro-resolving mediator involved in resolving inflammation rather than simply suppressing it, alongside IL-6, TNF-α, fasting glucose, insulin, and HOMA-IR.<sup>2</sup>"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]}
2039,"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/URUUQOKCBBBS3CIR6L2EGV35ZM.png","licensable":false,"alt_text":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","width":2000,"creditIPTC":"Provided by client","_id":"URUUQOKCBBBS3CIR6L2EGV35ZM","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","proxyUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/URUUQOKCBBBS3CIR6L2EGV35ZM.png","published":true,"resizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6&width=300","version":0,"originalName":"Figure-1.png","mime_type":"image/png","alt_text":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T08:39:29Z","last_updated_date":"2026-09-11T08:39:29Z","height":1315,"image_type":"photograph"},{"_id":"NUXIWGQQ3FCIBAHCT5KV7ZM6DY","additional_properties":{},"type":"text","content":"The group-by-time interaction for Maresin-1 was statistically significant, but the rise was confined to the two training arms (with and without fisetin), suggesting this particular resolution pathway needs an exercise stimulus to activate. IL-6 fell significantly in both training groups and in the fisetin-alone group, while the combined arm again produced the broadest pattern of improvement, extending to TNF-α, fasting glucose, insulin, and HOMA-IR."},{"_id":"GRCGTKCR5VGJPIEOD2GZEONK7A","additional_properties":{},"type":"text","content":"Read together, the two papers sketch a coherent, and appropriately nuanced, picture: fisetin has some independent activity on inflammatory and metabolic markers, but its most consistent and largest effects appear alongside training, and at least one specific pathway â Maresin-1-driven inflammation resolution â seems to depend on exercise rather than fisetin itself. "},{"_id":"KWBORRXD4JFMLJ5G7IUYNQXWSQ","additional_properties":{},"type":"text","content":"Whether fisetin genuinely amplifies the benefits of training, rather than simply adding to them through a separate mechanism, is a question this trial wasnât designed to isolate. Thatâs a sensible hypothesis for the next study to test directly, not a settled conclusion to market around."},{"level":3,"_id":"MRBQSKCSMZG3HMIHGNRWIFT52Y","additional_properties":{},"type":"header","content":"Why these fisetin benefits matter "},{"_id":"LZ6YUX5AGZA7PD5NXVO7OJGK3E","additional_properties":{},"type":"text","content":"For the industry, the interesting question is not just what fisetin is good for today, but what kind of ingredient it could become if this evidence base keeps building."},{"_id":"XCACYRQKWVA6BGA7HYBZIPF35Y","additional_properties":{},"type":"text","content":"The market has moved past the idea that healthy aging means stacking antioxidants into a formula. Todayâs longevity consumer wants to stay metabolically healthy and functional for longer. That opens at least four application territories for fisetin."},{"_id":"6DCYY5YKRRCFNN3VDQC2UCV3HU","additional_properties":{},"type":"text","content":"<b>Cellular longevity: </b>This remains fisetinâs most distinctive ground. Its link to senescence research gives it a position in the longevity category that conventional antioxidants cannot easily copy."},{"_id":"LL5KDB4YNJGSDIEHHONN5R7SBQ","additional_properties":{},"type":"text","content":"<b>Healthy aging: </b>The senescence story bridges naturally into formulations aimed at maintaining cellular and systemic health over time."},{"_id":"3QGPCXOZ5RAWDF72QHLIVF5MMI","additional_properties":{},"type":"text","content":"<b>Metabolic health: </b>
2039The 2026 data touch adipokines, lipids, glucose, insulin, and HOMA-IR, all central to the fast-growing metabolic health category. That is not grounds to position fisetin as a standalone weight-management ingredient. The more defensible proposition is supporting healthy metabolic function within a broader healthy-aging strategy, one that includes physical activity."},{"_id":"QQDTV44VYNDTPIV47DVEEEJ2DY","additional_properties":{},"type":"text","content":"<b>Inflammatory balance: </b>The Maresin-1 finding points beyond simply lowering inflammatory markers, towards how an ingredient interacts with the bodyâs own resolution machinery. It is a narrative the category has barely claimed."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg","licensable":false,"alt_text":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","width":1500,"creditIPTC":"Provided by client","_id":"3ZAEMGW7WJHKFJE25EC3GAXC5Q","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","proxyUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg","published":true,"resizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f&width=300","version":0,"originalName":"Figure-2.jpg","mime_type":"image/jpeg","alt_text":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T08:40:08Z","last_updated_date":"2026-09-11T08:40:08Z","height":927,"image_type":"photograph"},{"level":3,"_id":"YJ7B5G67XNGFTEC6CLPM5XZSJE","additional_properties":{},"type":"header","content":"Better science raises the bar for the ingredient"},{"_id":"UQJ6ZMNM5NEPNLAOTYSPMUQKAA","additional_properties":{},"type":"text","content":"A stronger research story cuts both ways. As fisetin becomes commercially attractive, the ingredient itself faces harder questions. Formulators are no longer asking only whether fisetin has interesting biology; they want to know whether they can source it with the quality, consistency, safety documentation, and evidence needed to build a credible product."},{"_id":"SNFSVQDLL5DVPA3CAJJSHLSMWY","additional_properties":{},"type":"text","content":"The fisetin in a clinical trial is a defined research intervention. A commercial ingredient has to deliver reproducible specifications, controlled purity, a characterized impurity profile and a proper safety dossier, plus human evidence tied to the material being sold. As the healthy-aging category matures, that gap between a promising molecule and a commercial-grade ingredient will draw more scrutiny, not less."},{"level":3,"_id":"SJRM4CRFAZDNLLETZTY7DH523E","additional_properties":{},"type":"header","content":"The next stage of fisetin science"},{"_id":"6N22Y7LBC5HZ3IA5BCXO5CLWGU","additional_properties":{},"type":"text","content":"This is the gap BeFisetin®, developed by Bonerge, is built to close. The fisetin powder pairs a defined specification with its own safety and clinical research foundation: more than 99% active content and less than 1% total impurities, by the companyâs reported specifications."},{"_id":"AUGW7VLICNGSHLXYNHA7UFQ3F4","additional_properties":{},"type":"text","content":"On safety, BeFisetin carries a Self-Affirmed GRAS (SA-GRAS) status, meaning an independent panel of qualified experts has concluded that the ingredient meets the âGenerally Recognized As Safeâ, standard under US law."},{"_id":"JX66Y6XP4BCRLLHWKNGJPUYDEM","additional_properties":{},"type":"text","content":"The bigger differentiator is the effort to connect ingredient quality with human evidence. In a completed clinical study in skin health, BeFisetin supplementation produced improvements in skin barrier function, elasticity, and the appearance of wrinkles â outcomes that sit inside one of the most established beauty-from-within categories. "},{"_id":"LWTCAHA65RB33OACCM22UDKSOM","additional_properties":{},"type":"text","content":"A second study is now underway in sleep health: a randomized, quadruple-blind, placebo-controlled trial (NCT06990256), evaluating BeFisetin alone and in combination with StanYouth urolithin A over 12 weeks in more than 80 middle-aged and older adults, with sleep quality and aging biomarkers as core readouts."}
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"},{"_id":"MIZZ5PEXTZBZHO6BQHOQI5ASNA","additional_properties":{},"type":"text","content":"For brands, that matters practically: high purity and a controlled impurity profile make formulation and finished-product specification easier to stand behind, and a proprietary clinical pipeline gives the finished product a story beyond ingredient-level trend momentum."},{"level":3,"_id":"O75EICG2XJFJNHT4NKWFDTWHXU","additional_properties":{},"type":"header","content":"What comes next"},{"_id":"V27KBHG6CJEPZM5JMNKIV2BTJA","additional_properties":{},"type":"text","content":"The 2026 papers mark the point at which fisetinâs human evidence began to catch up with its preclinical reputation. The open questions are clear: larger and longer trials, broader populations, optimal fisetin dosage, and a direct test of whether fisetin amplifies exercise-driven benefits. "},{"_id":"ZHUUVHXTWRHPRL4WL2JOPMFOF4","additional_properties":{},"type":"text","content":"If future work keeps connecting fisetin to senescence, inflammation resolution, and metabolic health, the ingredient could occupy a rare position across several major supplement trends at once."},{"_id":"FSY44TXQHJH3TEFL4RA2IHW5IU","additional_properties":{},"type":"text","content":"For the industry, the task is to work out whether fisetin can become a genuine platform ingredient for healthy aging, and whether suppliers can bring the rigor, purity, safety documentation, and proprietary evidence that transition demands. "},{"_id":"D4LKQXTQBZCLJCKQQIYLWM4KOQ","additional_properties":{},"type":"text","content":"That bar is rising. The ingredients that can meet it, with data precise enough to survive scrutiny, are the ones most likely to define what this category becomes."},{"_id":"PKSQHERT7JEIVE7TJON3GNWJT4","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"AJ4EQSAQWVC7FP5VFQHPXWLB2E","type":"list","items":[{"_id":"6PA6ZUQISRC5VFAG5YHQKRMB6M","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Alipour, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/41683255/\">The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. </a>Nutrients. 2026;18(3):433. "},{"_id":"P4DHDAS4OJHGPAYQKNOBHRGNGI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Alipour, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/42218768/\">12âweeks fisetin supplementation and interval resistance with aerobic training: changes in Maresinâ1 and inflammatory markers in men with obesity: a randomized controlled trial. </a>J Int Soc Sports Nutr. 2026;23(1):2679718. "}]}],"subheadlines":{"basic":"Two publications from a 2026 randomized controlled trial add human evidence on fisetin supplement benef
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Research has explored the botanicalâs support for stress management, sleep, and cognitive health, although differences in extract composition and standardization approaches remain an ongoing topic of discussion within the category."},{"level":3,"_id":"FUC574ZVOFGUJIEWOPSWCV3C3U","additional_properties":{},"type":"header","content":"Regulatory questions "},{"_id":"RHMVWAC6UBHGHN25ZRE2MSZRYE","additional_properties":{},"type":"text","content":"Alongside its commercial success, ashwagandha is facing intensifying scrutiny from authorities. Concerns have been raised by regulators around long-term safety, potential thyroid and reproductive effects, and uncertainty over safe intake levels. The US National Center for Complementary and Integrative Health has also noted rare cases of liver injury.<sup>2</sup>"},{"_id":"JVTQN3EHCJBFVIG32WY5TIO2QQ","additional_properties":{},"type":"text","content":"Denmark introduced restrictions on ashwagandha in 2023 following concerns around establishing safe intake thresholds. In 2024, national food safety authorities across Europe urged the European Commission to initiate an Article 8 assessment â a move that may confirm ashwagandhaâs safety and reassure national regulators, or potentially lead to EU-wide guidelines or restrictions. "},{"_id":"S2JB43T4UNGA3GG7CI23RM7O6M","additional_properties":{},"type":"text","content":"The TGA in Australia concluded that there was a very rare risk of liver injury with ashwagandha and advises consumers to be aware of potential gastrointestinal adverse effects and the possible risk of liver injury in very rare cases.<sup>3</sup> "},{"_id":"OZ7X7RQ7NRHPXKTP2VPWIIE3E4","additional_properties":{},"type":"text","content":"Industry stakeholders point to variability in extracts with plant part, extraction method, characterization and product specific substantiation all adding to this, creating challenges when comparing products and interpreting resesearch findings.<sup>4</sup> These differences sit at the heart of ongoing discussions around standardization, product quality, and how evidence should be interpreted across the category."},{"_id":"QPOQRZJFGFGNHIB6EDWCY2SRDM","additional_properties":{},"type":"text","content":"For manufacturers, this creates questions around formulation strategy, market access, and future investment decisions. The result is a fragmented landscape where brands must navigate differing national interpretations, evolving safety assessments and extract-specific considerations. "},{"level":3,"_id":"NLGQE7Y5BJA5ZNU4GH3ZSZJQKM","additional_properties":{},"type":"header","content":"Industry response: Clarity, quality, and communication"},{"_id":"3ZUODKC4WFDWXLEFOZAOIF3HW4","additional_properties":{},"type":"text","content":"With regulatory uncertainty mounting, industry stakeholders are stepping forward to address gaps in scientific communication and quality assurance. In May 2026 an industry led initiative, <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, was launched with support from leading manufacturer Kerry, this platform is designed to centralize peer-reviewed research, ensure public access to safety data, provide updates on regulatory developments and a live regulatory tracker outlining permitted uses across global markets."},{"_id":"CDICVCWJCFAQ3D5DR5G3RDNJA4","additional_properties":{},"type":"text","content":"The initiative reflects a broader industry push toward standardization â particularly around withanolide content, extraction methods, analytical testing, and traceability. As the category expands, many stakeholders argue that greater alignment around these will play an important role in supporting consumer trust and regulatory compliance. Indeed, the future of the category may depend on whether industry can build greater alignment."},{"level":3,"_id":"SDXUW3L4UBDELOHZRJCHZ37IAY","additional_properties":{},"type":"header","content":"Join our event"},{"_id":"34PEMIHLJFA3DCSPDMWHEXUUGQ","additional_properties":{},"type":"text","content":"In partnership with Kerry, NutraIngredients is hosting a Spotlight O
2039n <b>â</b>Ashwagandha: Understanding the Science, Scrutiny and Standardsâ. The broadcast will examine whether greater alignment around science, standards, and quality can help the industry navigate regulatory scrutiny to support the categoryâs growth. "},{"level":3,"_id":"FGRANCFHTJFUFHVCJDKTMETLME","additional_properties":{},"type":"header","content":"During the Spotlight broadcast you will:"},{"list_type":"unordered","_id":"4R6JU5VY2BC6XIWXA2INV6V2TU","type":"list","items":[{"_id":"IS2MB4NPDBGRFGMW36S7NAUE4I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Explore the clinical science behind ashwagandha with botanical quality and standardization expert Dr Thomas Brendler. "},{"_id":"A4QQ3FVKTJD7LLKO44J6EFFL5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Gain clarity on the regulatory pressures surrounding the ingredient from food lawyer Dr Mark Tallon. "},{"_id":"WO7XLE6IRJEJXDTTCUVAZYPCXQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how standardization and analytical testing can support greater consistency across botanical products from Petra Erlandson, VP of Sales at Alkemist Labs. "},{"_id":"IXGM5XPNIRFE7ICR3YPK7XXF7I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"See how brands are merging traditional knowledge with modern clinical validation with Dr Laura Collins, RDA Director of Cognitive Health at Kerry."},{"_id":"OASJNY34OVALVA4KGGU27FNULE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how brands are approaching ingredient selection, quality assurance and consumer demand in an increasingly scrutinized category with Jason Watkin, CEO of Canadian wellness brand Purica."}]},{"_id":"QFMPZQK2KVE7TKILJRYKXB7JHU","additional_properties":{},"type":"text","content":"<a href=\"https://tinyurl.com/PrePromoKerry\" target=\"_blank\" rel=\"\" title=\"https://tinyurl.com/PrePromoKerry\"><b>Register now to watch </b><i><b>Ashwagandha: Understanding the Science, Scrutiny and Standards</b></i><b> at 3pm BST, 4pm CEST, 9am CDT on 17 September 2026</b></a>"},{"_id":"B2GOOM25YFEERJNJPNPQNVZAFU","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"TPFA7UOJJRGVPHXX3AZP75YSCM","type":"list","items":[{"_id":"KERK755IVFDZNORE3IUNCPXRX4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pandey, D. <a href=\"https://www.precedenceresearch.com/ashwagandha-market\" target=\"_blank\" rel=\"\" title=\"https://www.precedenceresearch.com/ashwagandha-market\">Ashwagandha Market Size, Share and Trends 2026 to 2035</a>, Precedence Research."},{"_id":"J4W44QJPBVBCLNO7OL4QNTR4V4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"National Center for Complementary and Integrative Health, <a href=\"https://www.nccih.nih.gov/health/ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.nccih.nih.gov/health/ashwagandha\">Health Info, Ashwagandha</a>."},{"_id":"2TDHDVFTRVET5O5HTX3D3SJKFI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Australian Government, Department of Disability, Health and Ageing, <a href=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\">Herbal preparations containing Withania somnifera (Withania, Ashwagandha)</a>."},{"_id":"NWOV3HV2NVH23LHAJMGGOBOOAY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Domián, B. M.; et al. <a href=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\" target=\"_blank\" rel=\"\" title=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\">The ashwagandha paradox: a mixed-methods analysis of regulatory gaps, deceptive vendors and safety risks in the European online market</a>. Applied Food Research, Volume 6, Issue 2, December 2026, 102444."}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent. How can the industry align on science-based standards for quality assurance while ingredient use expands?"},"description":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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2039,{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg","licensable":false,"alt_text":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","width":1920,"creditIPTC":"Provided by client","_id":"N5R6EVCMGNEGVPFEEMNOSSGQZQ","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","proxyUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg","published":true,"resizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8&width=300","version":0,"originalName":"Figure-1.jpg","mime_type":"image/jpeg","alt_text":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:42:06Z","last_updated_date":"2026-08-13T10:42:06Z","height":960,"image_type":"photograph"},{"level":3,"_id":"I3X7Y76FPBAPDKSXFF6CJPNTT4","additional_properties":{},"type":"header","content":"Sleep health is becoming more than sleep initiation"},{"_id":"UGFWKRNS6VGFLOMC32WGYP67XI","additional_properties":{},"type":"text","content":"For decades, sleep supplements followed a relatively straightforward development strategy. Most products focused on one of three approaches:"},{"list_type":"unordered","_id":"VYKSNYCXRRGZJPX7MTIWV6PLUQ","type":"list","items":[{"_id":"5H5NX36UGNHIVCA5MBTPZ63RPI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Supporting circadian rhythm "},{"_id":"7CXNGMMAFFGGVPA56RB3GSHXAQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Promoting relaxation "},{"_id":"PBT6QI4NBZDQXFKIVFUQT3FJ2E","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Reducing nighttime nervous system activity "}]},{"_id":"RVUPBVWYTNC77KF7VEI6NHQUKQ","additional_properties":{},"type":"text","content":"Melatonin naturally became the dominant ingredient because it directly addressed sleep onset. Todayâs consumers, however, are grappling with sleep challenges that go well beyond simply falling asleep, including:"},{"list_type":"unordered","_id":"JCVZDPYF4FCB3LHJLVL6A6FCWA","type":"list","items":[{"_id":"H5O46GH3NJHUFLVS2SVJ4JVZGY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Fragmented sleep "},{"_id":"Z2LYO3UGT5CXLAHS6NJ57E35FU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Frequent nighttime awakenings"},{"_id":"VPTELN3NQ5CL3LJBZMNKPXQFOI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Light sleep"},{"_id":"CILK3CPGQFCO5PPVXJETK5XG24","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Early morning waking"},{"_id":"M3JWAMX6RBHLNGMZFQ7DGRTAVQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Waking up feeling unrefreshed de
2039spite sleeping for seven or eight hours "}]},{"_id":"TAOSFISBXVANDD6IL5YSBEX2NI","additional_properties":{},"type":"text","content":"These patterns are rarely driven by a single pathway. Instead, sleep quality is increasingly understood as the outcome of multiple interconnected physiological systems, including circadian biology, neurochemical balance, inflammation, metabolism, and age-related changes."},{"_id":"6LSFF5UV6ZB3RG5EJDBZ3YRP5Q","additional_properties":{},"type":"text","content":"Consequently, product innovation is evolving. Rather than relying on a single ingredient, many companies are developing multi-mechanism formulations designed to support both sleep quality and overnight recovery. "},{"_id":"D7MCZXIICBGFBCWVEGBZ56VMVM","additional_properties":{},"type":"text","content":"Natrolâs Sleep & Restore⢠portfolio illustrates this transition well, combining GABA, magnesium, vitamin B6, and botanical ingredients to support relaxation while expanding the product narrative beyond simply helping consumers fall asleep."},{"_id":"THYJZHCZ75FQDDIGRUHMVRX5TI","additional_properties":{},"type":"text","content":"The underlying message is becoming increasingly clear: sleep is no longer viewed as a single neurological event â it is increasingly recognized as a whole-body recovery process."},{"level":3,"_id":"FLPZSQSMGRGXNPZL764WTLXM5E","additional_properties":{},"type":"header","content":"Beyond relaxation: Where will non-melatonin innovation go next?"},{"_id":"AIUIOG65SZF5TEFP2RFFR6ABHE","additional_properties":{},"type":"text","content":"The first generation of non-melatonin sleep products largely replaced melatonin with alternative mechanisms."},{"_id":"FWCGUSBTRZD4ZDB77EQACWGICI","additional_properties":{},"type":"text","content":"Ingredients such as GABA, L-theanine, and magnesium became the categoryâs leading alternatives because they help regulate neuronal excitability and promote relaxation. Each has a well-established scientific rationale:"},{"list_type":"unordered","_id":"5YN2QNCCYZA7JJYNK3F37CVB5Q","type":"list","items":[{"_id":"ZWI5HVBXX5HCZLW2O55WCRO2UE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>GABA</b> supports inhibitory neurotransmission and helps reduce neuronal activity.<sup>2</sup>"},{"_id":"FIDXRXFKINBFDLHJ5BGSBWK2IE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>Magnesium</b> contributes to neuromuscular function and helps regulate excitatory neurotransmission.<sup>3</sup>"},{"_id":"I3XSOJVT25ENFIWYN22AL4KK54","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>L-theanine</b> has been studied for its ability to promote alpha brain wave activity associated with a relaxed mental state.<sup>4</sup>"}]},{"_id":"6O5PA6N6QRC2NCR2XYNEVY53AU","additional_properties":{},"type":"text","content":"These ingredients remain highly valuable. However, they largely address the same biological objective: reducing nervous system activation."},{"_id":"67PVAMFRC5C4RL4HYIDTPGU4QI","additional_properties":{},"type":"text","content":"This raises an important question for the future of sleep product innovation. If every non-melatonin formulation ultimately focuses on calming the nervous system, the market risks returning to familiar competitive territory â faster onset, stronger effects, or more noticeable sensations."},{"_id":"VMHYXYHLUZATHE6ZKZVDN7IERM","additional_properties":{},"type":"text","content":"Yet consumers are asking a different question: why has my sleep quality deteriorated in the first place?"},{"_id":"GIKCJCLC4FDCXNJO4PYS3J2IGA","additional_properties":{},"type":"text","content":"Answering that question requires expanding beyond neurotransmitters to examine the broader physiological environment influencing sleep. One of the most promising scientific frameworks emerging from this shift is the gut-brain axis."},{"level":3,"_id":"DVSPRQ3DMBHGRKKLMZSIEHYIYU","additional_properties":{},"type":"header","content":"The gut-brain axis is expanding the science of sleep"},{"_id":"WM5RY6R7MVAUZLOCBKQAOQYWHM","additional_properties":{},"type":"text","content":"Sleep has traditionally been viewed as a brain-centered process. While the central nervous system remains the primary regulator of sleep, advances in microbiome research, metabolomics, and systems biology have revealed that sleep regulation extends well beyond the brain itself."},{"_id":"HA4YWOKHNVBF5LJWALRZQZUXDU","additional_properties":{},"type":"text","content":"The gastrointestinal tract communicates continuously with the central nervous system through microbial metabolites, immune signaling, neural pathways, and endocrine communication.<sup>5</sup>"},{"_id":"H5F2QRFGRRFT7OL2K3I5MP53PQ","additional_properties":{},"type":"text","content":"Collectively, these interactions form what is now known as the gut-brain axis. Its significance lies not in the simplistic notion that âthe gut influences the brainâ, but in providing a more integrated understanding of sleep biology."},{"list_type":"unordered","_id":"NYTIZ6GH6FCXNBQRPZFLUXXPBM","type":"list","items":[{"_id":"BPTWBPGI5JGRPLVC3LE2A7GVFE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Intestinal barrier integrity can influence systemic inflammatory signaling"},{"_id":"H6BDFKJSCRG6HMHIYDL5SQVWOY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Low-grade chronic inflammation may affect neurological function"}
2039,{"_id":"J4ENIDVJBFFRBDFMZHXXFVO65I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Metabolic disturbances can interfere with circadian regulation"}]},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg","licensable":false,"alt_text":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","width":1920,"creditIPTC":"Provided by client","_id":"2V53XADCHNHE7F5Q2VFCPBE7QI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","proxyUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg","published":true,"resizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798&width=300","version":0,"originalName":"Figure-2.jpg","mime_type":"image/jpeg","alt_text":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:43:13Z","last_updated_date":"2026-08-13T10:43:13Z","height":996,"image_type":"photograph"},{"_id":"DWCPINHWRZDGBKMZ7BL6ZPIPEQ","additional_properties":{},"type":"text","content":"Viewed together, these interconnected pathways suggest that sleep quality may depend as much on systemic physiological balance as on central nervous system signaling."},{"_id":"4JNQQHEYNBGUXD2N6EOFHUHC4U","additional_properties":{},"type":"text","content":"This broader perspective is prompting researchers to revisit a number of bioactive compounds that were never originally developed as sleep ingredients."},{"level":3,"_id":"7E5OOVBJ5BFADMALUJHJPG2FTI","additional_properties":{},"type":"header","content":"Why urolithin A is emerging as a promising sleep recovery ingredient"},{"_id":"D7ZTQ3G3FRBTLDR5K35Z2VH6FI","additional_properties":{},"type":"text","content":"Among these emerging compounds, urolithin A (UA) has attracted growing scientific interest."},{"_id":"LL4D5HELCRCBZNR3DDSCUXQFFI","additional_properties":{},"type":"text","content":"Unlike traditional sleep ingredients, urolithin A did not originate from sleep research. Urolithin A is a naturally occurring postbiotic metabolite generated by gut microbiota from dietary ellagitannins."},{"_id":"CWMWM7U7TNGPVBGMZSTF2ETNVE","additional_properties":{},"type":"text","content":"Over the past decade, research on the benefits of urolithin A has expanded from gut microbiota metabolism to broader areas of systemic physiology, including intestinal barrier function, metabolic regulation, cellular homeostasis, and biological resilience."},{"_id":"RJZQZ6XOBNABBJFN4EHQCOM6TU","additional_properties":{},"type":"text","content":"Ironically, that broader scientific foundation may be precisely why it has become interesting for sleep health. Rather than acting as a conventional sleep aid that primarily targets neuronal relaxation, urolithin A is being investigated for its potential to supp
2039ort the physiological systems that contribute to restorative sleep."},{"level":3,"_id":"N5M2LFE6EVEA7HSJRJKFDC72CE","additional_properties":{},"type":"header","content":"A natural fit for gut-brain axis research"},{"_id":"T24QDP7CHNDQTM2DHRTEDUDS7Y","additional_properties":{},"type":"text","content":"Because urolithin A is produced through gut microbial metabolism, it naturally occupies a unique position within gut-brain axis research."},{"_id":"H3XHXGRWAZEILONK7V5EVVEOXE","additional_properties":{},"type":"text","content":"Multiple studies have demonstrated that urolithin A can influence intestinal tight junction proteins, promote protective mucus layer formation, and support mucosal immune defense. Together, these actions contribute to maintaining intestinal barrier integrity â an important upstream factor in gut-brain communication.<sup>6,7 </sup>"},{"_id":"VGJKFNUAKVBNJNCMERCMDIHNRE","additional_properties":{},"type":"text","content":"Instead of directly targeting sleep pathways, urolithin A may help create a healthier physiological environment that supports sleep regulation."},{"level":3,"_id":"FSU6KANVYFEHZITFGDSVDJFJHE","additional_properties":{},"type":"header","content":"Recovery rather than sedation: Supporting restorative sleep"},{"_id":"RBUCMJNLNJGLTOFTFYSXN77EFQ","additional_properties":{},"type":"text","content":"One of the most distinctive aspects of urolithin A is that its scientific story revolves around recovery, not sedation."},{"_id":"DSUD2NMMFREZFN2B5U7IL2G6H4","additional_properties":{},"type":"text","content":"Emerging sleep science increasingly recognizes that restorative sleep and physiological recovery are deeply interconnected."},{"_id":"UTNPWUWNQFCKLLVDZLWLKU443A","additional_properties":{},"type":"text","content":"Interestingly, many of urolithin Aâs previously published studies â although not designed specifically for sleep â share a common theme: improving resilience and recovery."},{"_id":"EQEERQZUSZFRVHGHBNRLJPJF3M","additional_properties":{},"type":"text","content":"For example, a preclinical study from South China Normal University reported that urolithin A reduced neuroinflammation, attenuated glial activation, lowered pro-inflammatory cytokine expression, and improved physical performance following sleep deprivation.<sup>8</sup>"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg","licensable":false,"alt_text":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","width":1920,"creditIPTC":"Provided by client","_id":"4AYDK67AORBZPCBBOQMXIGKRPQ","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","proxyUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg","published":true,"resizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331&width=300","version":0,"originalName":"Figure-3.jpg","mime_type":"image/jpeg","alt_text":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:44:01Z","last_updated_date":"2026-08-13T10:44:01Z","height":1067,"image_type":"photograph"},{"_id":"S5CHJSSATJF7XOHUD6UW6OPTCQ","additional_properties":{},"type":"text","content":"Although these findings remain preclinical, they provide mechanistic supp
2039ort for exploring urolithin A for sleep as a recovery-oriented ingredient rather than a conventional sleep aid."},{"level":3,"_id":"7KHE3CVC6JGWLISEB4XGPTQQAM","additional_properties":{},"type":"header","content":"A new connection with circadian biology"},{"_id":"WYWW6YZAPVCZXIMGGLY26TXNLA","additional_properties":{},"type":"text","content":"Another emerging area of research involves circadian rhythm regulation. Recent studies suggest that urolithin A may influence the rhythmic expression of core clock genes such as BMAL1 and PER2, helping preserve circadian oscillations under inflammatory conditions.<sup>9</sup>"},{"_id":"Y55ZYIHRCJB3VJHL5RB7QIOO64","additional_properties":{},"type":"text","content":"Animal studies have also reported changes in circadian-related gene expression within the suprachiasmatic nucleus (SCN), the bodyâs master biological clock.<sup>9</sup>"},{"_id":"RYVNHSSUMBFFJOTJGYUJGYT4HQ","additional_properties":{},"type":"text","content":"In senescent cell models, urolithin A has been shown to increase the amplitude of BMAL1 oscillation by approximately four-fold in a dose-dependent manner.<sup>10</sup>"},{"_id":"3A5QJQXJZJB4NKFSPFTFNUIFRY","additional_properties":{},"type":"text","content":"Although these findings require confirmation in human studies, they provide intriguing evidence that urolithin A may influence both peripheral and central circadian regulatory networks."},{"level":3,"_id":"JX7I3ETY5RAEHHFR5JQSCOIRHE","additional_properties":{},"type":"header","content":"From mechanistic research to clinical validation"},{"_id":"AJNSX4GRWNHA3FVSLXLEDXRONI","additional_properties":{},"type":"text","content":"Mechanistic evidence is essential â but it is not enough. Ultimately, the commercial value of any functional ingredient depends on whether mechanistic hypotheses translate into measurable human outcomes."},{"_id":"5NZHAY7JKVD6ZA5BAW5BZ3OWTM","additional_properties":{},"type":"text","content":"Recognizing this, StanYouth® Urolithin A has initiated a randomized, quadruple-blind, placebo-controlled clinical trial (NCT06990256) involving adults with impaired sleep quality."},{"_id":"4NUSYX5N2BHF3FM3PZ44VXE3JE","additional_properties":{},"type":"text","content":"The 12-week study compares urolithin A alone, fisetin alone, their combination, and placebo. Importantly, the trial extends beyond subjective sleep questionnaires. Researchers are incorporating polysomnography (PSG), wearable actigraphy, aging biomarkers, and gut microbiome analysis to evaluate subjective sleep experience, objective sleep architecture, and underlying biological mechanisms simultaneously."},{"_id":"OHFTIRHU5VHBXEH4POYRKWBKWI","additional_properties":{},"type":"text","content":"This multidimensional design reflects a broader shift occurring across the dietary supplement industry: the future of sleep innovation will increasingly depend on robust clinical evidence rather than mechanistic speculation alone."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/THRB3EWH4JHUNC34RG44Q44K7Q.jpg","licensable":false,"alt_text":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","width":1920,"creditIPTC":"Provided by client","_id":"THRB3EWH4JHUNC34RG44Q44K7Q","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","proxyUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/THRB3EWH4JHUNC34RG44Q44K7Q.jpg","published":true,"resizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202&width=300","version":0,"originalName":"Figure-4.jpg","mime_type":"image/jpeg","alt_text":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:44:42Z","last_updated_date":"2026-08-13T10:44:42Z","height":1138,"image_type":"photograph"},{"level":3,"_id":"EL3CS5V7J5BBBILLEPTMUKNGQI","additional_properties":{},"type":"header","content":"The future of sleep supplements may be about recovery"},{"_id":"IO4YE3VRVZAMPKGYAYED3WCO7U","additional_properties":{},"type":"text","content":"Melatonin is unlikely to disappear from the sleep category. Nor should it. It remains one of the most effective ingredients for supporting circadian rhythm and sleep onset."},{"_id":"UZ5BONS7NBCNNKGRPGWY736Y64","additional_properties":{},"type":"text","content":"However, consumer expectations are changing. The next generation of sleep supplements is unlikely to compete solely on how quickly consumers fall asleep. Instead, success may increasingly depend on helping consumers wake up restored, resilient, and physiologically recovered. That is the promise of a true sleep recovery supplement."},{"_id":"JVJOCFX7WFEJPA3KNP4ARXHGMM","additional_properties":{},"type":"text","content":"As scientific understanding expands from neurotransmitters to the gut-brain axis, circadian biology, and systemic recovery, ingredients such as StanYouth Urolithin A represent an entirely new direction for sleep health innovation."},{"_id":"JSVFJXE3HFCQTODPGOJNTXNVX4","additional_properties":{},"type":"text","content":"The future of the category may no longer be defined by sleep aid. It may instead be defined by<b> </b>Sleep Recovery."},{"_id":"I5YICOG5OVDYNK7L6EV5NCG3NQ","additional_properties":{},"type":"text","content":"<a href=\"https://www.bonerge.com/branded-ingredients/stanyouth-urolithina\" target=\"_blank\" rel=\"\" title=\"https://www.bonerge.com/branded-ingredients/befisetin-fisetin\"><b>Find out about StanYouth here.</b></a>"},{"_id":"BDTORJZXQNEDZKYS2RXOMLHRLM","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"WKGWBGAD3NA5POYPGUBWV6QZBE","type":"list","items":[{"_id":"6MWFAXUXJBBPJJAPCLWRBJ5M5Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"PR Newswire. <a href=\"https://www.prnewswire.com/news-releases/natrol-the-nations-top-melatonin-brand-introduces-soothing-night-its-first-sleep-aid-supplement-without-melatonin-301933546.html\">Natrol®, the Nationâs Top Melatonin Brand, Introduces Soothing Night®, Its First Sleep Aid Supplement Without Melatonin.</a>"},{"_id":"7NYRW6YCNVB5FD2ZL3OIKGAXDY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Chen, RJ.; et al. <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK526124/\">GABA Receptor.</a> StatPearls Publishing. 2026."},{"_id":"YFOLIAMYZNGK7HQ3VZZUT4G4E4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kothari, M.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC11444808/\">A comprehensive review on understanding magnesium disorders: Pathophysiology, clinical manifestations, and management strategies.</a> Cureus. 2024 Sep 1;16(9):e68385. "},{"_id":"XYUWZWFBZFFBNAI2KAIQSK2XWI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Nobre AC.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/18296328/\">L-theanine, a natural constituent in tea, and its effect on mental state.</a> Asia Pac J Clin Nutr. 2008;17(Suppl 1):167-168."},{"_id":"HPZCBGIT4BFQBNPZYVEK7PIJOA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Chen, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/40952592/\">Microbiotaâgutâbrain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets.</a> Mol Biomed. 2025 Sep 15;6:64."},{"_id":"SYV33PZ7LVAGZKD6TTERIS6XDE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Ghosh, S.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/42336837/\">Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.</a> Nat Commun. 2026 Jun 23;17(1):5411. "},{"_id":"HRPA4JOERBC2HJ5WRVZN3J2KPE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Yasuda, T.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38977770/\">Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis.</a> Sci Rep. 2024 Jul 8;14(1):15706. "},{"_id":"WC63GSWVMJEBVOPVQD6MZYQXNA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Zhu, H.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38977770/\">Urolithin A Ameliorates Athletic Ability and Intestinal Microbiota in Sleep Deprivation from the Perspective of the Gut-Muscle Axis.</a> Mol Nutr Food Res. 2024 Apr;68(7):e2300599. "}
2039,{"_id":"3U2KCDSXZNEXRL66YM646DRREI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Du, Y.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39064706/\">Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation.</a> Nutrients 2024, 16, 2263."},{"_id":"3NQP5AUVKZDPPOI6TYLQRVORUE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kuatov, R.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39796454/\">Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells.</a> Nutrients 2025, 17, 20."}]}],"subheadlines":{"basic":"As sleep supplements shift from sleep aid to sleep recovery, urolithin A is emerging as a gut-brain axis ingredient for restorative, non-melatonin sleep."},"description":{"basic":"As sleep supplements shift from sleep aid to sleep recovery, urolithin A is emerging as a gut-brain axis ingredient for restorative, non-melatonin sleep."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Promotional features","description":"","_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"website":"nutraingredients-v2","navigation":{"nav_title":"Promotional features","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Promotional-features"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Promotional features","_id":"/News/Promotional-features","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Regions/Europe","parent":{"default":"/Regions"},"_website":"nutraingredients-v2","parent_id":"/Regions","name":"Europe","description":"","_id":"/Regions/Europe","additional_properties":{"original":{"parent":{"default":"/Regions","main-navigation":"/Regions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Europe","root_section":"false","type":"region"},"_admin":{"alias_ids":["/Regions/Europe"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Europe","_id":"/Regions/Europe","regions_tabs":{"latam":"false","emea":"false","apac":"false","noam":"false"},"order":{"default":35,"main-navigation":35}}},"_website_section_id":"nutraingredients-v2./Regions/Europe","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"navigation-links":"/","default":"/","main-navigation":"/"},"website":"nutraingredients-v2","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"navigation":{"nav_title":"Health conditions","root_section":"true","type":"news"},"_admin":{"alias_ids":["/Health-conditions"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Health conditions","_id":"/Health-conditions","ancestors":{"navigation-links":["/"],"main-navigation":["/"]},"order":{"navigation-links":1004,"default":23,"main-navigation":1004}}},"_website_section_id":"nutraingredients-v2./Health-conditions","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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A drug class capable of driving double-digit percentage weight loss can substantially reduce food intake, changing the nutritional challenges patients face during treatment and potentially beyond it."},{"_id":"EKOA5OOQCZAT7B3LKM6SJW4SRE","additional_properties":{},"type":"text","content":"That is because the same appetite suppression driving the headline results of GLP-1s is creating a quieter issue underneath the topline weight-loss figures. A significant share of that weight loss can come from lean mass rather than just fat, while substantially reduced food intake raises questions about whether some patients may struggle to meet their needs for protein and other nutrients."},{"_id":"JO6UVNG65FESFIU7K6O6RSM75Y","additional_properties":{},"type":"text","content":"As clinical and formulation attention shifts from simply how much weight patients lose to what kind, the question of how to support muscle health throughout GLP-1 therapy is becoming one of the more pressing conversations in nutrition science. Alongside established strategies such as adequate protein intake and resistance exercise, omega-3 fatty acids are being investigated for their potential to support muscle health and help preserve lean mass during weight loss."},{"level":3,"_id":"CJL5YHNCSBBTZEU6Y5AVYS52NI","additional_properties":{},"type":"header","content":"The GLP-1 nutritional squeeze"},{"_id":"AAXZRWE4PNCFDNWBWKTGLVXYJ4","additional_properties":{},"type":"text","content":"GLP-1s work by suppressing appetite, and that mechanism is central to their effectiveness. Patients on these medications have been shown to consume 16 to 39% fewer calories than before starting treatment.<sup>3</sup> Gastrointestinal side effects, including nausea, early satiety and slower gastric emptying, add a further layer of difficulty around eating enough to meet nutritional requirements, or eating a varied enough diet."},{"_id":"UK3EOK7SYFB6LO7YHK3RAUXNXY","additional_properties":{},"type":"text","content":"Reduced intake affects total nutrition, but muscle mass is where the impact has drawn the most attention. Research suggests that around 20% to 50% of weight lost during GLP-1 treatment may comprise lean body mass.<sup>4</sup> This has prompted dietitians, formulators and pharmaceutical companies alike to look more closely at what patients need nutritionally to protect muscle while losing weight quickly."},{"_id":"H33AK447ORFCRATIIAK7O2BIPI","additional_properties":{},"type":"text","content":"Protein has understandably become the focal point of that response. However, with appetite suppressed and food volume down, patients may also be at risk of inadequate intake of protein, vitamins, minerals and other essential nutrients, even when weight loss itself is tracking as expected.<sup>4</sup> This is leading to deeper questions being asked on what âcompleteâ nutrition should look like when individuals are taking GLP-1s."},{"level":3,"_id":"UH2PCOM2KFCATHQJM2T3APWY3E","additional_properties":{},"type":"header","content":"Protein and exercise remain foundational"},{"_id":"UZUSOFTXHJAPTAU2LA44ZN7UBQ","additional_properties":{},"type":"text","content":"None of this changes the fundamentals of muscle preservation during weight loss. Higher protein intake, with targets commonly proposed around 1.2g to 2g per kg per day during active weight reduction, combined with resistance training, is among the best-supported strategies for protecting lean mass during any period of energy restriction.<sup>5</sup> "},{"_id":"ZPKSEUKX5BET3JGAP2ZBWJZDBQ","additional_properties":{},"type":"text","content":"Clinical guidance for GLP-1 patients has largely reinforced that message, with dietitians and obesity medicine specialists prioritising protein intake and strength training as first-line advice."},{"_id":"MNO6RFM7WNHPVCCG2GHVUIEHPI","additional_properties":{},"type":"text","content":"The difficulty is putting that guidance into practice. Patients dealing with suppressed appetite and gastrointestinal side effects can struggle to reach recommended protein targets through food alone, and reduced intake elsewhere in the diet compounds the problem. "},{"_id":"K5HMDDA24RAXFNKZQE5XCZSF7M","additional_properties":{},"type":"text","content":"That gap between recommendation and reality is what is driving interest in additional nutritional support, including ingredients like omega-3 fatty acids, which can work alongside protein and exercise rather than replace them."},{"level":3,"_id":"BJZXB4XVBZEL3GG5QCSBYQ5J6M","additional_properties":{},"type":"header","content":"Where omega-3 fits in"},{"_id":"R42XLSMKRRCJRG3RL24M3M4JJQ","additional_properties":{},"type":"text","content":"The interest in omega-3 fatty acids and muscle health predates the GLP-1 boom by well over a decade. The two long-chain omega-3s most relevant to this discu
2039ssion are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), both found predominantly in oily fish and fish oil. The theory is that these fatty acids do not just sit passively in the diet. Once consumed, they can be incorporated into skeletal-muscle membranes, where research suggests they may influence signalling pathways involved in muscle protein synthesis and breakdown."},{"_id":"KTPMDWXJ5FAPZEAQIKR72ZOSTY","additional_properties":{},"type":"text","content":"A review of the underlying biology has linked DHA and EPA incorporation into skeletal-muscle membranes with changes in anabolic signalling and muscle protein turnover.<sup>6</sup> "},{"_id":"F7AVNNWTY5CN5ERXCXCWRXGZ5Q","additional_properties":{},"type":"text","content":"On the clinical side, a randomized controlled trial in older adults found that omega-3 supplementation enhanced the muscle protein synthesis response to amino acids and insulin, helping the body make more effective use of the protein it does receive.<sup>7 </sup>While this study was not conducted in people taking GLP-1 medications, it provides clinical evidence that omega-3 may influence muscle protein synthesis in older adults."}
2039,{"_id":"6LDSDWGQHBCS7LR5VHSINSPHH4","additional_properties":{},"type":"text","content":"A 2020 meta-analysis of 10 randomized controlled trials in 552 older adults found that omega-3 supplementation was associated with a small but statistically significant gain in muscle mass compared with control groups, with a larger effect seen among participants taking more than 2g per day.<sup>8</sup> The analysis also reported improvements in some measures of physical performance."},{"_id":"4USMHVE5IBB3NHNEAAE5JG6FV4","additional_properties":{},"type":"text","content":"A 2023 systematic review of 21 intervention studies in adults examined omega-3 in a range of formats, including formulations combining omega-3 with protein, leucine and vitamin D, as well as products incorporating omega-3 into enteral nutrition. The review found that a substantial number of individual studies suggested potential benefits for maintaining or gaining muscle mass.<sup>9</sup>"},{"_id":"35WKZPI4ZNAXXMHLVEXVRK2R5Q","additional_properties":{},"type":"text","content":"The findings also point to omega-3 being studied as part of broader nutritional strategies, rather than solely as a standalone supplement. This is a relevant consideration when thinking about the nutritional needs of people taking GLP-1s."},{"level":3,"_id":"GCHIYHPCVZAQNGEX4YWKTAKMSE","additional_properties":{},"type":"header","content":"The formulation challenge"},{"_id":"SVYPOQLH35G4RNRKZDD2CKEXDE","additional_properties":{},"type":"text","content":"Though research into omega-3âs role in muscle health continues to grow, getting the supplement into a product that patients will actually take consistently is its own challenge. Fish oilâs sensory drawbacks are well documented: oxidation, a fishy aftertaste and lingering odor have long limited its use in everyday formats like powders, shakes and stick packs. "},{"_id":"RLGNQZUPBZBRNAAMVB4F43MXWA","additional_properties":{},"type":"text","content":"A capsule regimen is one more thing to remember on top of medication schedules, appetite changes and gastrointestinal (GI) symptoms, and for many patients that is a barrier to consistent use."},{"_id":"2Z4Z4LV3HVBJVN7ITGINW4WU4Y","additional_properties":{},"type":"text","content":"This is the problem microencapsulation is designed to solve. The process coats the omega-3 oil in a protective layer, guarding against oxidation and masking taste and odor, which allows DHA and EPA to be built directly into palatable, nutrient-dense formats rather than confined to capsules. This innovation simplifies omega-3 fortification in nutrient dense food and beverage applications. "},{"_id":"PZ3XWLAVYFEOHG5PMQYH6DDIN4","additional_properties":{},"type":"text","content":"For manufacturers, the opportunity is not to position omega-3 as a replacement for protein or resistance exercise, but as a complementary nutritional strategy within a broader approach to muscle health during GLP-1-supported weight management. As research continues to explore how DHA and EPA may influence muscle protein metabolism, omega-3 is emerging as an area of interest alongside the more established foundations of adequate protein intake and resistance exercise."},{"_id":"HEZACAUOHZDFJEIEFWLOU77ZNY","additional_properties":{},"type":"text","content":"The challenge is translating that science into products that consumers can realistically incorporate into their daily routines. Microencapsulation can help address some of the sensory and stability challenges associated with omega-3, opening up opportunities to deliver DHA and EPA in convenient formats. "},{"_id":"DK5KZSOIRVGMHMHZ65ZPZXOXFU","additional_properties":{},"type":"text","content":"For formulators responding to the nutritional demands of the growing GLP-1 market, combining established nutritional strategies with emerging ingredients and practical delivery formats could become an increasingly important part of the conversation."},{"_id":"XWEOCYMURRDIPHW3PCQ55DPRZY","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"MF477KNFMNBC5ON5MBF5MMNQDE","type":"list","items":[{"_id":"QUMQM6JYERG6JEWP3GLWPYB4SU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"KFF. <a href=\"https://www.kff.org/public-opinion/poll-1-in-8-adults-say-they-are-currently-taking-a-glp-1-drug-for-weight-loss-diabetes-or-another-condition-even-as-half-say-the-drugs-are-difficult-to-afford/\">Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford.</a>"},{"_id":"X6KHJI4WEFGEXHRE4UNBIABG3I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"ING. <a href=\"https://think.ing.com/articles/transformative-or-overhyped-the-impact-of-weight-loss-drugs-on-european-food-demand1/\">Transformative or overhyped? The impact of weight-loss drugs on European food demand.</a> "},{"_id":"YNHWJCUOJBBQNHMAQYVPRAAHFY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Christensen, S.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39175746/\">Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: a narrative review and discussion of research needs.</a> Obes Pillars. 2024;11:100121. "},{"_id":"HJQUZWRAMZGIZDBK6FRRHPPIBI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Johnson, BVB.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/41368199/\">Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: a narrative review.</a> Obes Pillars. 2025;16:100209."},{"_id":"TOAQ7D3ATBATDGIJCXVDGR7P2E","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Mozaffarian, D.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/40445127/\">
2039Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society.</a> <i>Am J Clin Nutr</i>. 2025;122(1):344-367."},{"_id":"FEO3IZFQ5BC6DN5JKF7MAZP3D4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"McGlory, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/31555658/\">The influence of omega-3 fatty acids on skeletal muscle protein turnover in health, disuse, and disease.</a> Front Nutr. 2019;6:144."},{"_id":"XWS2MEM5PVCNPC5PT5YHKTF57I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Smith, GI.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/21159787/\">Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial.</a> <i>Am J Clin Nutr</i>. 2011;93(2):402-412. "},{"_id":"RHOQLX3EFFANZC24GE3CX3SRLM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Huang, YH.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/33291698/\">Effects of omega-3 fatty acids on muscle mass, muscle strength and muscle performance among the elderly: a meta-analysis.</a> Nutrients. 2020;12(12):3739."},{"_id":"CFKFXYAKORGWXE7DIEOW4WTDVA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Moon, GK.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/37969938/\">Effects of omega-3 fatty acid supplementation on skeletal muscle mass and strength in adults: a systematic review.</a> Clin Nutr Res. 2023;12(4):304-319."}]}],"subheadlines":{"basic":"As GLP-1 use grows worldwide, concern over lost lean mass alongside weight loss is rising, but research points to omega-3âs potential role in supporting lean mass."},"description":{"basic":"As GLP-1 use grows worldwide, concern over lost lean mass alongside weight loss is rising, but research points to omega-3âs potential role in supporting lean mass."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Weight-management","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Weight management","description":"","_id":"/Health-conditions/Weight-management","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Weight management","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Weight-management"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Weight management","_id":"/Health-conditions/Weight-management","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"order":{"default":27,"main-navigation":27}}},"_website_section_id":"nutraingredients-v2./Health-conditions/Weight-management","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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2039hwagandha ingredients for both safety and efficacy. "},{"_id":"SPLCM45SGNEOJMZJBIE4BQW3IE","additional_properties":{},"type":"text","content":"âWe saw modern science literally supporting traditional use here,â Low Dog said when discussing research based on KSM-66 root extract, investigating stress and cortisol management. "},{"_id":"DT7ZSCJ5VNEWJBHURIVTKMHYWM","additional_properties":{},"type":"text","content":"This includes a 12-month safety study, a 12-week high-dose study at 2,000 mg/day<sup>,</sup> and a large global study involving more than 1,000 participants.<sup> 2-4</sup> Together, these studies demonstrate that KSM-66 has been evaluated across longer durations, higher doses and a large participant population, making it one of the most comprehensively studied ashwagandha root extracts from a safety perspective."},{"_id":"7ODB4YEFXJGVLIWW7WRVVL43VQ","additional_properties":{},"type":"text","content":"âWhat is particularly important is that the research has examined not only efficacy, but also safety across longer durations, higher doses and large participant populations,â said Low Dog. âThat breadth of evidence gives formulators and consumers a more complete understanding of the specific extract.â"},{"_id":"YA4PRU6D7JHEJPQDDYDBX4I6VY","additional_properties":{},"type":"text","content":"Low Dog examined evidence across multiple areas, including stress management, sleep quality, cognitive function, sports performance, healthy ageing, menâs health and womenâs wellbeing. She also emphasised the importance of understanding exactly which extract is used in clinical research."},{"_id":"BAHCOTQBDBBAVJABTL6D5VINQY","additional_properties":{},"type":"text","content":"âNot all root extracts or ashwagandha extracts are equivalent,â said Low Dog. âWe want to know if weâre looking at the clinical research, what was the clinical research done on? Is the extract reproducible and is the research reproducible?â KSM-66 is a root-only extract with 5% total withanolides, produced by a green chemistry extraction process. It also has a fully integrated vertical supply chain. "},{"_id":"ZCMZXEABRZH5HIAOLL4PRNA46U","additional_properties":{},"type":"text","content":"Discussing the relevance of adaptogens for consumers in todayâs increasingly busy and demanding world, Low Dog described how certain botanicals may help support the bodyâs ability to cope with everyday stressors."},{"_id":"UQN4ZYAHXJFRXF2GD3LRQ4C6QE","additional_properties":{},"type":"text","content":"âThere are plants that help the body increase its capacity, widen the margin for resilience, and over time allow people to manage their stress more effectively⦠Ashwagandha is the most calming of the adaptogens,â she continued."},{"level":3,"_id":"SEBIXIUQSRBV5P5H2LBJUZPQOI","additional_properties":{},"type":"header","content":"Consumer demand for stress and sleep support"},{"_id":"QCSEHQMALJANFPIWOMOCFA67K4","additional_properties":{},"type":"text","content":"As consumer interest in ashwagandha increases, the opportunity for evidence-backed ingredients that have been researched in relation to benefits for improving sleep and stress grows. "},{"_id":"7NMQIBJQWZGF5I5PDGXDIV6PGI","additional_properties":{},"type":"text","content":"Jordan Rubin, natural health expert, formulator and founder of Garden of Life, Ancient Nutrition and Beyond Organic, believes ashwagandha is a vital ingredient in the formulatorâs toolbox. He explores the category, and looks at KSM-66âs performance specifically, in a SPINS data in the video below."},{"subtype":"jw_player","_id":"24VMYKGZRVEMBKML5HLX5W74AU","embed":{"id":"kGntZi0D","config":{"image":"https://cdn.jwplayer.com/v2/media/kGntZi0D/poster.jpg?width=720","id":"kGntZi0D","title":"SPINS%20category%20presentation"},"url":"https://cdn.jwplayer.com/players"},"type":"custom_embed"},{"_id":"FAXRJA3JAFDJLO6UXFUSZSIVF4","additional_properties":{},"type":"text","content":"Ewa Hudson, Lumina Intelligence, presented new data that highlighted sleep as the leading health concern across genders and age groups with stress ranking second among health concerns. And according to the research, consumers experiencing higher levels of stress are increasingly turning to adaptogens, including ashwagandha, as part of their wellbeing routines.<sup>5</sup>"},{"_id":"CZAVD4AS6NHJJCREU3QNGQPIRQ","additional_properties":{},"type":"text","content":"âThe older we become, the more we look at our diet and supplementation, and it actually over indexes here as weâre hitting 30,â Ewa explained. âBy recognising how wellness routines change with age and showing up as a consistent, supportive partner alongside these daily activities, brands can actually become truly trusted partners.â"},{"_id":"JVAYT7GSYNE5NGUUQ6TJVFLE54","additional_properties":{},"type":"text","content":"This growing interest in adaptogens is something Jordan Rubin has observed during more than 25 years in the supplement industry as a formulator. Drawing on SPINS market data, Rubin highlighted the growth of products containing KSM-66 across both in bricks-and-mortar retail stores and ecommerce channels."},{"_id":"KJVTQEQLUVEJTBZOYKWSALPYCI","additional_properties":{},"type":"text","content":"âEight out of the 10 fastest growing brands of ashwagandha [are] utilising KSM-66 as their premier ingredient⦠on Amazon out of the best-selling ashwagandha products, the only branded ingredient that is used is KSM-66 Ashwagandha,â said Rubin. âAnd most importantly, [itâs] backed by dozens of randomised controlled trials and truly represents an ingredient for this generation.â"},{"level":3,"_id":"BXVDFLN4NJCHXPVI46PRHVX4UA","additional_properties":{},"type":"header","content":"Regulatory considerations"},{"_id":"SRY5GH2KYFFI3FT55HS2J545PQ","additional_properties":{},"type":"text","content":"Alongside the growing consumer interest in ashwagandha, regulatory developments are becoming increasingly important for the sector."},{"_id":"JRN7JSRAS5D5FI5VLJ7I7RY6WA","additional_properties":{},"type":"text","content":"Mari Lyyra, regulatory affairs manager at Medfiles, a consultancy that works with companies across the food and supplement sectors to navigate regulatory frameworks, provided an overview of the current European landscape, explaining that while ashwagandha is not considered a novel food ingredient in the EU, questions continue to be raised around safety assessments, extract characterisation and differences between plant parts. "},{"_id":"SUSDMQA2EJEERE2626GRE25IY4","additional_properties":{},"type":"text","content":"Lyyra set out the different phytochemical profiles of different plant parts. âItâs clear that root and other plant parts need to be separated and more characterisation, and safety data on different ashwagandha parts and products and extracts is needed,â she said. "},{"_id":"GT6LC2QH5FB57JTAYK64BVVZR4","additional_properties":{},"type":"text","content":"Lyyra also discussed ongoing regulatory reviews taking place across Europe and n
2039oted that any future EU-wide assessment process could take considerable time to complete. "},{"_id":"32XGT6E3UFE5VBYHXIBMPF73LA","additional_properties":{},"type":"text","content":"For manufacturers and formulators, this underlines the importance of ingredient labelling, supply-chain transparency and robust safety data as the category continues to mature. There have been reports of ashwagandha adulteration globally, highlighting the importance of robust quality controls, accurate labelling and supply-chain transparency. KSM-66 positions its vertically integrated supply chain as a means of supporting traceability and consistency.<sup> 6</sup>"},{"level":3,"_id":"MW45OOFB7ZBR7AA53VY2PBPMTI","additional_properties":{},"type":"header","content":"Formulatorâs viewpoint "},{"_id":"VOILXAAEBFBMNH2K4XGI7DFLSE","additional_properties":{},"type":"text","content":"As regulatory scrutiny increases, transparency around sourcing, standardisation and ingredient selection is becoming increasingly important for brands operating in the category."},{"_id":"KLE7RWTWTNBVNKVC7AP2LO2YBA","additional_properties":{},"type":"text","content":"In this Spotlight On, Tom Johnsson explored the ingredient from a formulatorâs standpoint. As founder of the Medicine Garden brand, he talked about the benefits of using KSM-66 Ashwagandha: "},{"_id":"IUMN2OE6L5AM5HR2ALBOJ2E7BY","additional_properties":{},"type":"text","content":"âWe have been working actually 40 years in the health industry and weâve always been focusing on adaptogens⦠But we have never, ever worked with a supplement that gives so much positive feedback from the consumer,â said Johnsson."},{"_id":"MVXUKXBYGFCNZBYAGUD26FNGAU","additional_properties":{},"type":"text","content":"âThe main reason why we [use] it is of course what it can do for the consumer, but itâs also that the very even grade of extraction makes it very easy to flow in the capsule. There are no additives into the capsules. So we can use clean label, and that is also very important for us.â"},{"_id":"MMYU2ELCONCARDEWHRHHP5HOAM","additional_properties":{},"type":"text","content":"<b>To discover more about KSM-66âs scientific studies and why transparency is so important in the face of category regulation, watch </b><a href=\"https://onlinexperiences.com/scripts/Server.nxp?LASCmd=AI:4;F:QS!10100&ShowUUID=22780238-8307-4824-A01E-C7DD245C235B&GroupID=Onyx&AffiliateData=Web-Webbox-ASHWASPOTKSMJUNE26_NI&Referrer=https%3A%2F%2Fwww.nutraingredients.com%2F\" target=\"_blank\" rel=\"\"><b>Ashwagandha: Science, regulation and transparency</b></a><b> on demand now.</b>"},{"_id":"SWUQJZYET5DPFNTU4AFFDNNBDE","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"QSWQX6NK4RDXLCT5WFXR2KQD34","type":"list","items":[{"_id":"GBFLBRENTRBTHBPNHEJ7CWXAH4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Grand View Research. <a href=\"1.%09https:/www.grandviewresearch.com/industry-analysis/ashwagandha-supplements-market-report\">Ashwagandha Supplements Market (2026 - 2033)</a>"},{"_id":"3POTIWZWZFGXBK622ARFHOCZQE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Salve J.: et al. <a href=\"https://onlinelibrary.wiley.com/doi/10.1002/ptr.70096\">Safety of 12-Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study.</a> Phytotherapy Research. 2025. "},{"_id":"K3DQHSPNGVCJBO6SM45OFVPSJA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Movva N.: et al. <a href=\"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1823678/full\">Safety and tolerability of Ashwagandha (Withania somnifera) root extract in healthy adults: a prospective, non-comparative study.</a> Frontiers in Nutrition. 2026;13:1823678. "},{"_id":"FYPRQK7J45CO5BHJGVSJQ4OCV4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pakhale K.: et al. <a href=\"https://onlinelibrary.wiley.com/doi/10.1002/ptr.70315\">Safety of 8-Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi-Center, Double-Blinded, Placebo-Controlled Study.</a> Phytotherapy Research. 2026. "},{"_id":"LFKRMBNST5HNJH2JWTE6ZQHO5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Lumina Intelligence. <a href=\"https://www.nutraingredients.com/Article/2026/04/08/lumina-reveals-how-womens-health-priorities-and-self-care-is-shifting/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/04/08/lumina-reveals-how-womens-health-priorities-and-self-care-is-shifting/\">Global Nutrition Consumer Research</a>. November 2024 (n= 6,000)"},{"_id":"YNZQ4QKPVNHDJES7TP3YUADTIQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"American Botanical Council. <a href=\"https://www.herbalgram.org/news/press-releases/2025/bapp-new-ashwagandha-root-extract-adulteration/\" target=\"_blank\" rel=\"\" title=\"https://www.herbalgram.org/news/press-releases/2025/bapp-new-ashwagandha-root-extract-adulteration/\">
2039BAPP Publishes Laboratory Guidance Document on Ashwagandha Root and Root Extract Adulteration</a>"}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha grows, how can science-backed ingredients and greater transparency help build trust among consumers, formulators and regulators? "},"description":{"basic":"As consumer demand for ashwagandha grows, how can science-backed ingredients and greater transparency help build trust among consumers, formulators and regulators? "},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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2039se considerations are becoming increasingly important for maintaining consumer confidence and regulatory trust."},{"level":3,"_id":"4YANPE6X3BCTVPZY4IWBHBB6AQ","additional_properties":{},"type":"header","content":"Regulators raise concerns over safety and consistency"},{"_id":"DDOVH4CUIVDJNNYC7VH3GQSHIM","additional_properties":{},"type":"text","content":"In Europe, Denmark moved to ban ashwagandha in 2023, citing difficulties in establishing safe intake levels. Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all comes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve c
2039ommunication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
2039ss the key issues shaping the future of the category."},{"_id":"WK4Y3HVPWND4LNWCNBVIALLFNU","additional_properties":{},"type":"text","content":"<a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\"><b>Watch: âAshwagandha: Understanding the Science, Scrutiny and Standardsâ On Demand now to learn about the latest developments in the ashwagandha category.</b></a><b> </b>"}],"subheadlines":{"basic":"A deep dive into the science behind ashwagandha, the regulatory considerations and what the future holds for the category. 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The next opportunity is connecting them.</b>"},{"_id":"4AAQ7DJVLFARDLVVDYL5KKFAF4","additional_properties":{},"type":"text","content":"Borrowing a concept from technology, a âfull stackâ brings together the different layers required to create a complete solution. The parallel to nutrition and wellness is compelling: while the industry may operate in individual layers, consumers experience the outcome as a whole."},{"_id":"TNRNUTHIQBA2FGAPBRYD7ZJI2M","additional_properties":{},"type":"text","content":"Consumers do not think about ingredient suppliers, formulation constraints, dosage-form technologies, manufacturing capabilities, or regulatory pathways. They think about outcomes<i>:</i> they want more energy; to stay strong; to sleep better; to perform better; and feel like the best version of themselves. "},{"_id":"3RYWYQF6ONBGJE4W5ZCPGIRF2I","additional_properties":{},"type":"text","content":"Industry has traditionally approached those needs one layer at a time, shaped in part by where each company sits in the value chain. What if the next wave of innovation comes not only from advancing each individual layer, but from connecting them? That is the idea behind Full-Stack Wellness: an approach that starts with the consumer need and connects the layers required to address it â insight, science, ingredients, formulation, delivery, manufacturing, and, ultimately, the consumer experience."},{"_id":"E4CYL6DVSNBMZKNSOKYWTU7A7E","additional_properties":{},"type":"text","content":"TSI sees four opportunities for companies across the wellness ecosystem to put full-stack thinking into practice: design around the consumer rather than the category; design delivery alongside the science; solve the whole consumer problem; and connect the physical and digital wellness experience."},{"level":3,"_id":"DPA5J22Z4FCOBIF4UWM6CO2PUA","additional_properties":{},"type":"header","content":"Design around the consumer, not the category"},{"_id":"TV7MN5C6ZNDQ7K3SZEBPNDE5ME","additional_properties":{},"type":"text","content":"One of the clearest shifts in wellness is toward greater personalization. Consumers increasingly expect products and routines to reflect their goals, lifestyles, and life stages rather than offering one answer for everyone."},{"_id":"OQAJHFH4IZBTTM3NCCN4T2M5DQ","additional_properties":{},"type":"text","content":"Innova Market Insights describes a continuum ranging from bespoke programs informed by biomarkers and DNA to more scalable personalization using questionnaires and âlifestyle stacksâ aligned with specific wellness objectives. Innova also points to the rise of hybrid and bundled products designed to address multiple needs while making wellness choices easier for consumers.¹"},{"_id":"T5GMKLWLOBA3PIXM6PBAWGJTPM","additional_properties":{},"type":"text","content":"But personalization is about more than tailoring a recommendation. It changes where innovation begins. Instead of asking, âwhat ingredient should we sell?â or âwhat product should we make?â, the better questions are: Who is this consumer? What are they trying to accomplish? And what combination of science, nutrition, format, and experience can best support that goal?"}
2039,{"_id":"WNDUPVMPM5HXRNCG6NRG2AGBKQ","additional_properties":{},"type":"text","content":"Starting there makes traditional category boundaries less important. Consumers do not experience wellness according to the organizational structure of our industry. Their needs overlap, interact, and change over time."},{"_id":"UMOO6WDMFVDAXAQBPWA2A6MF74","additional_properties":{},"type":"text","content":"Longevity is a good example. A consumer may not identify as an athlete or even think of themselves as a âhealthy agingâ consumer. They may simply want to stay strong, think clearly, recover well, and continue doing the things they enjoy. Addressing that outcome may require thinking across muscle health, cognition, mobility, metabolic health, sleep, and nutrition rather than choosing a single category."},{"_id":"HCD7UEVFH5DSTFASDYZSSYUGEM","additional_properties":{},"type":"text","content":"TSI sees an opportunity to develop around health outcomes rather than individual ingredients. That can mean synergistic ingredient systems, science-backed combinations, and a more holistic view of health categories."},{"_id":"ODJ2WXCPSJC2FHD2X64GBUBED4","additional_properties":{},"type":"text","content":"Full-Stack Wellness does not mean putting every possible benefit into one product. It means understanding the complete consumer need and determining which combination of science, ingredients, formats, and experiences can address it most effectively. The need comes before the SKU, and the outcome comes before the category."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg","licensable":false,"alt_text":"Supplement delivery formats","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Supplement delivery formats","width":831,"creditIPTC":"Provided by client","_id":"HHH7Q3CP2NBHXLBSMII57VG2F4","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","proxyUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg","published":true,"resizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748&width=300","version":0,"originalName":"NI_TSI_Multi_Delivery_Formats-1.jpg","mime_type":"image/jpeg","alt_text":"Supplement delivery formats","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:14:31Z","last_updated_date":"2026-09-11T10:14:31Z","height":303,"image_type":"photograph"},{"level":3,"_id":"NPMDYR5KMNEHTLRY4Z2WCGIHSA","additional_properties":{},"type":"header","content":"Design the delivery alongside the science"},{"_id":"CB2EU6VNBFAQRD77JY6YH2VHDY","additional_properties":{},"type":"text","content":"Selecting the right ingredients is only part of creating a successful wellness solution. Consumers also must want to use it."},{"_id":"JPTCWJIKHVDA7IK62XJJRPUMBE","additional_properties":{},"type":"text","content":"That makes dosage form, delivery technology, taste, convenience, and experience part of product strategy â not decisions made after the science is settled. Gummies remain important, but innovation now spans shots, stick packs, direct-to-mouth powders, and granules, gels, soft chews, functional foods and beverages, and increasingly food-like formats."}
2039,{"_id":"LL2YMUZF6NA3TEYOVPXHHAU7CI","additional_properties":{},"type":"text","content":"The shift is showing up in consumer behavior: NIQ reports that functional beverages now generate 1bn in average monthly popularity, reflecting a broader movement of wellness beyond traditional pills and powders and into everyday food and beverage experiences.²"},{"_id":"S7ZCNZSFABF35E6ZBKZFMFJUGA","additional_properties":{},"type":"text","content":"TSI think about format as a differentiator, not simply a container for the ingredients. On-the-go formats and direct-to-mouth delivery can change when and where a product fits into someoneâs life, while novel delivery technologies can create entirely new product experiences."},{"_id":"7V5PUUFQFJA6DAPNG5MUJPLL5Y","additional_properties":{},"type":"text","content":"TSIâs FZZRâ¢, for example, offers a different way to think about supplement delivery, with the options to âdrink, buzz, or chewâ. The point is not that one format is right for every consumer. It is that format itself can be part of solving the consumer need. "},{"_id":"NHDZDAAERBGO7FC2ENOPO47BT4","additional_properties":{},"type":"text","content":"Each format brings considerations around dose, stability, sensory experience, portability, and consumer preference. The development journey becomes increasingly connected:"},{"_id":"OQ4FEFV32VGVBJAL4K3NHDNQ5A","additional_properties":{},"type":"text","content":"Science â Ingredients â Formulation â Delivery â Experience â Adherence â Outcome"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/C2EA556KINFODHV6VYHQSWR24Y.jpg","licensable":false,"alt_text":"Full development journey","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Full development journey","width":831,"creditIPTC":"Provided by client","_id":"C2EA556KINFODHV6VYHQSWR24Y","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","proxyUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/C2EA556KINFODHV6VYHQSWR24Y.jpg","published":true,"resizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4&width=300","version":0,"originalName":"NI_TSI_Multi_Full_Development_Journey.jpg","mime_type":"image/jpeg","alt_text":"Full development journey","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:13:30Z","last_updated_date":"2026-09-11T10:13:30Z","height":303,"image_type":"photograph"},{"_id":"M4VOFTMNOFG5NBZSA7DW2YHGMA","additional_properties":{},"type":"text","content":"Thinking across those layers earlier can reveal possibilities and tradeoffs that may be missed when the ingredient is selected first and the delivery experience is figured out later. The question is no longer only âwhat should be in it?â but also âhow should the consumer experience it?â."},{"level":3,"_id":"7HYJESD4A5HGDLKERBQMJU2C2M","additional_properties":{},"type":"header","content":"Solve the whole consumer problem"},{"_id":"MQD2E3RG5VF53JX624EPSGSDKA","additional_properties":{},"type":"text","content":"GLP-1s offer a timely example of what systems thinking looks like in practice. A consumer using a GLP-1 does not simply have a âweight-managementâ need. Changes in appetite and food intake can create considerations around protein, muscle preservation, fiber, hydration, micronutrient density, and digestive tolerance."},{"_id":"FVXRQ4QTSRE6NCZ33FROOVRONY","additional_properties":{},"type":"text","content":"And consumers are already trying to navigate those needs themselves. PwC foun
2039d that 80% of current GLP-1 users are piecing together their own routines with supporting products, pointing to an opportunity for more integrated wellness solutions.³"},{"_id":"F3Q2VZUM7JBWDNYMKBNYVLIIHI","additional_properties":{},"type":"text","content":"Creatine offers an interesting example. Once associated primarily with bodybuilding and sports performance, it is increasingly relevant to broader conversations around muscle health and wellness."},{"_id":"EGMUO3L47BB27NJHYOIXTCT7RY","additional_properties":{},"type":"text","content":"TSI see that evolution reflected in interest in OptiCreatineâ¢, its proprietary premium creatine platform. Its improved solubility, rapid dissolution, and reduced sedimentation open opportunities beyond the traditional scoop into formats such as chewables, fast-melt powders, effervescent pellets, and sprinkles."},{"_id":"V3VGN64AOFBU7IZ4QBWPTYLM4A","additional_properties":{},"type":"text","content":"But the Full-Stack Wellness opportunity is bigger than creatine or any single ingredient. The better question is: how is this consumerâs nutritional ecosystem changing, and where can nutrition meaningfully support that journey?"},{"_id":"C26S4F4NZRAFDHR47PNXDWEHEA","additional_properties":{},"type":"text","content":"The answer may involve macro and micro ingredients plus different formats as needs and behaviors change. That is systems thinking: start with the whole consumer problem, then build the solution around it."},{"level":3,"_id":"E6HQU6L45ZFFTJJUX25HYKQCNM","additional_properties":{},"type":"header","content":"Connect the physical and digital stack"},{"_id":"7RNAAZKIVJDDBBXEWUIXQK4YKY","additional_properties":{},"type":"text","content":"The wellness stack does not necessarily end when a product reaches the consumer. Technology is adding another layer as wearables, apps, and other digital tools generate information around activity, sleep, recovery, stress, and individual goals."},{"_id":"DKCBW7GGZFDKDFCUENYH46CZHQ","additional_properties":{},"type":"text","content":"And consumers are acting on those insights. EYâs 2026 US Consumer Health Survey found that 55% of consumers track their health data, and 82% of those who do say they changed health-related behaviors such as exercise, diet, or sleep in the past year.â´"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg","licensable":false,"alt_text":"EY consumer health survey","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"EY consumer health survey","width":831,"creditIPTC":"Provided by client","_id":"MQ74TRAH2ZE5RCKJ5MYGTVRL7U","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","proxyUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg","published":true,"resizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969&width=300","version":0,"originalName":"NI_TSI_Multi_US_Consumer_Health_Survey_Data.jpg","mime_type":"image/jpeg","alt_text":"EY consumer health survey","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:18:46Z","last_updated_date":"2026-09-11T10:18:46Z","height":303,"image_type":"photograph"},{"_id":"2AX5M3RCRRGC5JPQCIFTJMKIYM","additional_properties":{},"type":"text","content":"AI may add another dimension, helping translate those signals into more personalized recommendations, product discovery, and new-product opportunities. This is where the technology origins of âfull stackâ become especially relevant:"},{"_id":"OXPCFGB3UZE4LOFKDEWB3DL3NQ","additional_properties":{},"type":"text","content":"Data â Insight â Recommendation â Science â Solution â Delivery â Behavior â Feedback â Refinement"},{"_id":"36XB3B2N6NGSTOPQPJTLC6Z4YQ","additional_properties":{},"type":"text","content":"The feedback loop may be the most interesting part. Learn more about the consumer. Identify a need. Develop or recommend a solution. Understand how it fits into their life. Then use what you learn to produce relevant outcomes."},{"_id":"MR5DQJZSXJBHNMKZQIWFZ667ZE","additional_properties":{},"type":"text","content":"Not every company needs to own every layer of the stack. Few will. Full-stack thinking isnât about owning everything. Itâs about seeing the whole picture and knowing where the right capabilities and partnerships can connect it."},{"level":3,"_id":"BE7NMJB5TRCIJG3DFLX4XBFQ4M","additional_properties":{},"type":"header","content":"What happens when we connect the stack?"},{"_id":"SN5FY3IEQFDNHBDZCDV32KGAJE","additional_properties":{}
2039,"type":"text","content":"Great science will continue to matter. So will great ingredients, formulations, formats, manufacturing, and technology. But none of these connect themselves. It takes people â with expertise, curiosity, and the ability to see across disciplines â to bring the stack together. But increasingly, some of the most interesting innovations may happen in the connections between them."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/QFALUPDXYVBIBI52I22U3TOJBI.jpg","licensable":false,"alt_text":"Multiple delivery formats","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Multiple delivery formats","width":831,"creditIPTC":"Provided by client","_id":"QFALUPDXYVBIBI52I22U3TOJBI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","proxyUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/QFALUPDXYVBIBI52I22U3TOJBI.jpg","published":true,"resizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8&width=300","version":0,"originalName":"NI_TSI_Multi_Delivery_Formats-2.jpg","mime_type":"image/jpeg","alt_text":"Multiple delivery formats","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:17:13Z","last_updated_date":"2026-09-11T10:17:13Z","height":303,"image_type":"photograph"},{"_id":"2RQBJXYTJREETJGFVYLCZGY3IQ","additional_properties":{},"type":"text","content":"Thatâs what makes Full-Stack Wellness exciting to TSI. Its work spans consumer insights, science, ingredients, synergistic systems, formulation, delivery technologies, and manufacturing. That gives us an opportunity to start with a consumer need and ask a bigger question: what could the solution look like if we werenât limited by where one part of the value chain ends and another begins?"},{"_id":"QRI7YOU5UJAPFJNKZNCJXHQHIU","additional_properties":{},"type":"text","content":"Sometimes the answer may be a science-backed combination built around a health outcome. Sometimes it may be giving a familiar ingredient new relevance through a different format or consumer experience. And sometimes it may come from connecting capabilities or ideas that havenât traditionally been connected at all."},{"_id":"BF3TNNSNTVHIRMD53BEML2JIKQ","additional_properties":{},"type":"text","content":"It is unknown where Full-Stack Wellness will lead, but thatâs what makes the conversation interesting."},{"_id":"K55SXFZ435HHDEVEGWCTEITRVY","additional_properties":{},"type":"text","content":"So, bring TSI the consumer need you are trying to solve, or the ingredient that deserves a better experience, the product that needs a rethink, or the âwhat if we tried this?â idea. "},{"_id":"PE4XUOIN2VCZHDNE53W45RVC34","additional_properties":{},"type":"text","content":"The next great wellness solution may already exist in pieces. The opportunity is connecting the right ones. Letâs see what happens when we connect the stack."},{"_id":"5BZMGF56HRAWVHLYR3FG7ZEG34","additional_properties":{},"type":"text","content":"<b>If youâll be at SupplySide Global in Las Vegas this October, come find TSI. TSI will be sharing some of the science, ingredients, formats, and ideas in progress â and would love to hear yours. </b>"},{"_id":"ZFQ6ZTPI3NCG5JX2S3HMZWYEKI","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"SOC5HG2D4FCM5LUF5B4KWRFWFE","type":"list","items":[{"_id":"GPSSBGXTHRDXLF3NESVJU2ZH4U","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Innova Market Insights. <a href=\"https://www.innovamarketinsights.com/trends/us-supplement-market-trends/\">US Supplement Market Trends: Personalized Wellness & Hybrid Growth.</a> "},{"_id":"4E3PJXWBPZE4RK5XFGFQPIE4QM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"NielsenIQ. <a href=\"https://nielseniq.com/global/en/insights/analysis/2025/blurring-wellness-boundaries-when-supplements-meet-food-and-beverage/\">Blurring Wellness Boundaries: When Supplements Meet Food and Beverage.</a>"},{"_id":"Y6N2BAASUZBMLPMABOULKNAF3U","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"PwC. The End of More: How GLP-1 Users Shop, Eat, and Seek Support. "},{"_id":"2VTKX7NKG5FOTLA757F3S4ACZE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"EY. <a href=\"https://www.ey.com/en_us/insights/health/ey-us-consumer-health-survey-2026\">EY US Consumer Health Survey 2026.</a>"}]}],"subheadlines":{"basic":"The next wave of wellness innovation isnât a single ingredient. Itâs connecting science, delivery, and technology to solve real consumer needs."},"description":{"basic":"The next wave of wellness innovation isn't a single ingredient. It's connecting science, delivery, and technology to solve real consumer needs."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"News","description":"","_id":"/News","additional_properties":{"original":{"parent":{"
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2039se considerations are becoming increasingly important for maintaining consumer confidence and regulatory trust."},{"level":3,"_id":"4YANPE6X3BCTVPZY4IWBHBB6AQ","additional_properties":{},"type":"header","content":"Regulators raise concerns over safety and consistency"},{"_id":"DDOVH4CUIVDJNNYC7VH3GQSHIM","additional_properties":{},"type":"text","content":"In Europe, Denmark moved to ban ashwagandha in 2023, citing difficulties in establishing safe intake levels. Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all comes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve c
2039ommunication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
2039ss the key issues shaping the future of the category."},{"_id":"WK4Y3HVPWND4LNWCNBVIALLFNU","additional_properties":{},"type":"text","content":"<a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\"><b>Watch: âAshwagandha: Understanding the Science, Scrutiny and Standardsâ On Demand now to learn about the latest developments in the ashwagandha category.</b></a><b> </b>"}],"subheadlines":{"basic":"A deep dive into the science behind ashwagandha, the regulatory considerations and what the future holds for the category. 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But identifying relevant biological mechanisms is only the beginning. Human evidence and meaningful, measurable outcomes matter, as do effective dose, bioavailability, stability and dosage-form fit."},{"_id":"TGTZEMAUYVFOHBJCLRNMVFM4ZM","additional_properties":{},"type":"text","content":"Together, these considerations are reshaping not only how healthspan products should be developed, but also what developers should look for in an ingredient. AstaReal® Natural Astaxanthin offers a compelling example of this new approach."},{"level":3,"_id":"4JUF473FCFDGBDI5PE2E4TTBEE","additional_properties":{},"type":"header","content":"The hallmarks of ageing: A framework, not a claims checklist"},{"_id":"D2EBHTAD25ALHFO6QMTWUTA6DM","additional_properties":{},"type":"text","content":"First proposed in 2013 and expanded in 2023, the hallmarks of ageing framework describes 12 inter-related biological processes that contribute to ageing, classified into three categories. "},{"_id":"EHLNMPKDHFCHJPBAJDJPX5MZCU","additional_properties":{},"type":"text","content":"Primary Hallmarks represent sources of cellular damage that accumulate over time. Antagonistic hallmarks reflect responses to that damage that may initially be adaptive or protective but can become detrimental when sustained or dysregulated. Integrative hallmarks arise as the downstream effects of these processes converge, contributing more directly to declining tissue homeostasis, function and resilience.<sup>1,2</sup>"},{"_id":"HYM6UXGQRNFJPLOUKSLHYFI5KE","additional_properties":{},"type":"text","content":"Importantly, the 12 hallmarks should not be viewed as independent ageing processes. Their classification reflects a broader progression from cellular damage, through biological responses to that damage, to increasingly systemic and functional consequences. "},{"_id":"JT6LJDP4QJEX7LNWBQTDIMKM5E","additional_properties":{},"type":"text","content":"At the same time, the hallmarks interact across categories, creating feedback and reinforcing effects throughout the ageing process, as shown below in Figure 1."},{"_id":"IQHWB4IBRRB3ZOVPJVXI3QIBB4","additional_properties":{},"type":"text","content":"Together, the hallmarks provide a biological map for understanding the complex biology of ageing. But to read that map dynamically, it is important to understand n
2039ot only which hallmarks are involved, but how they evolve over time and interact with one another."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8"},"vanity_credits":{"affiliation":[]},"caption":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OE2HL5WITBGDFACMNYAX2QZB5A.png","licensable":false,"alt_text":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","width":831,"creditIPTC":"Provided by client","_id":"OE2HL5WITBGDFACMNYAX2QZB5A","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","proxyUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OE2HL5WITBGDFACMNYAX2QZB5A.png","published":true,"resizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8&width=300","version":0,"originalName":"Figure1.png","mime_type":"image/png","alt_text":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:34:13Z","last_updated_date":"2026-08-21T15:34:13Z","height":303,"image_type":"photograph"},{"level":3,"_id":"FG2XWOEQWVF2XCSNVI7HU6BXWE","additional_properties":{},"type":"header","content":"Rethinking product development in the healthspan era"},{"_id":"BA2DEQ3KQNCSZJE7O73JSGXU2U","additional_properties":{},"type":"text","content":"The hallmarks of ageing framework highlights an important consideration for healthspan product development: changes in ageing biology may begin before functional decline becomes apparent. "},{"_id":"AI665BBOMFBQZPASL5BURW6LFA","additional_properties":{},"type":"text","content":"Healthspan nutrition is therefore not only about responding to age-related decline, but also about supporting the underlying biology that helps maintain function and resilience over time."},{"_id":"5FROUHUTLRBNPG62RKNUQKIA6U","additional_properties":{},"type":"text","content":"The starting point for product development should be the healthspan objective and not an ingredient or an individual hallmark. Healthspan is multidimensional, spanning physical, cognitive and sensory function, metabolic health and resilience.<sup>3,4</sup> "},{"_id":"KMPHBZMONRBUDHF4TOWQFGOSAQ","additional_properties":{},"type":"text","content":"A broad healthspan formulation may address several complementary domains, while a more targeted product may prioritise one or two. The key is to first define the target population and the healthspan outcomes that matter for them."},{"_id":"C6ODLKULRNGDBEEIMO2SI2O7HI","additional_properties":{},"type":"text","content":"âLongevityâ itself is not a practical endpoint for most nutrition products. It must be translated into outcomes that can be studied and monitored. These priorities can then guide the identification of relevant ageing biology and the choice of clinical endpoints, biomarkers and, ultimately, ingredients and ingredient combinations."},{"level":3,"_id":"LJ7FTYLMXNDR5OTGTI4JWWOJTM","additional_properties":{},"type":"header","content":"Two gates for ingredient selection"},{"_id":"XQQPB5RJVRD2HCGQYBG6BQ3AYM","additional_properties":{},"type":"text","content":"Once the healthspan objective and relevant biology have been identified, potential ingredients need to pass through two important gates: an evidence gate and a formulation gate."}
2039,{"_id":"BJVUWIIU35GCTFXFSG77GQ72SY","additional_properties":{},"type":"text","content":"The evidence gate asks whether there is credible human evidence to support an ingredientâs relevance to the intended healthspan objective. Mechanistic and preclinical evidence can establish biological plausibility, but developers should also consider whether the ingredient has been studied in a relevant population, at an achievable dose and against outcomes relevant to the intended objective.<sup>5</sup>"},{"_id":"UPEPRY7GQJC4RFBT7N7JCIZ73A","additional_properties":{},"type":"text","content":"The formulation gate asks whether that evidence can be translated into a viable product. Can an evidence-based dose be delivered in the intended dosage form? Is the ingredient sufficiently bioavailable and stable? Is it compatible with other ingredients?"},{"_id":"TC33BPDVYNDZ7KRDADN2LRQ47E","additional_properties":{},"type":"text","content":"Passing one gate does not guarantee passing the other. A compelling biological rationale without relevant human evidence may be insufficient to support ingredient selection. Equally, strong clinical evidence may have limited practical value if the evidence-based dose or formulation cannot realistically be delivered in the intended product."},{"_id":"J2KUDPP2WZHUBNFOR7FXBZTSZA","additional_properties":{},"type":"text","content":"Together, these two gates provide a practical bridge between the biology of ageing and the development of credible healthspan products â helping ensure that ingredient selection is guided not simply by mechanistic potential, but by human evidence and real-world formulation feasibility."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35"},"vanity_credits":{"affiliation":[]},"caption":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OWSM7M23Y5HCJBHO6ZPHWATINI.png","licensable":false,"alt_text":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","width":831,"creditIPTC":"Provided by client","_id":"OWSM7M23Y5HCJBHO6ZPHWATINI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","proxyUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OWSM7M23Y5HCJBHO6ZPHWATINI.png","published":true,"resizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35&width=300","version":0,"originalName":"Figure2.png","mime_type":"image/png","alt_text":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:34:49Z","last_updated_date":"2026-08-21T15:34:49Z","height":303,"image_type":"photograph"},{"_id":"ODMAYFXY4FBD3M7FHNU65QPT2Q","additional_properties":{},"type":"text","content":"<b>Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development</b>"},{"level":3,"_id":"H6XARJUGOBGOTN3BOOOAJAF5KA","additional_properties":{},"type":"header","content":"From biological relevance to human evidence"},{"_id":"GUQU6TI5HRBDPOAIPIQFSSHNZU","additional_properties":{},"type":"text","content":"Healthspan-oriented product development places new demands on ingredient selection. The strongest candidates are those whose biological actions are relevant to the intended healthspan objective and are supported by evidence that these actions translate into outcomes in people. "},{"_id":"CFXOG53HJJGVJJNNQ4WKSKS5PA","additional_properties":{},"type":"text","content":"AstaReal natural astaxanthin provides a foun
2039dation to bring these two dimensions together: broad biological relevance across inter-linked processes associated with healthy ageing, supported by an extensive body of human clinical research."},{"_id":"RH7VRFAN7BDOXJJQTOGNFFOQY4","additional_properties":{},"type":"text","content":"Mechanistic and preclinical research has shown that astaxanthin interacts with multiple biological processes involved in cellular resilience and homeostasis, including mitochondrial function, energy metabolism, oxidative stress responses, inflammation, nutrient sensing and cellular quality control. "},{"_id":"FAY2NOFZP5AM7HM37XOFSM5BJI","additional_properties":{},"type":"text","content":"Importantly, research is beginning to reveal how these processes are closely associated. For example, AstaReal astaxanthin has been shown to activate AMPK signaling, with downstream upregulation of SIRT1 and PGC-1α thereby enhancing mitochondrial biogenesis and energy metabolism.<sup>6</sup>"},{"_id":"KHW4KAD3NZCDTIWYIZQVHQ6MSI","additional_properties":{},"type":"text","content":"Other research using AstaReal astaxanthin suggests that regulation of IGF-1/Akt/FoxO3a and IGF-1/Akt/mTOR signaling may contribute to the induction of autophagy.<sup>7</sup> Together, these findings illustrate how astaxanthin can influence such interacting biological networks rather than isolated pathways â providing mechanistic links to multiple hallmarks of ageing. "},{"_id":"DZSS7VLHBZHURPH4VYZBT4KBGA","additional_properties":{},"type":"text","content":"Importantly, this biological relevance is accompanied by substantial human evidence. AstaReal astaxanthin has been investigated in more than 85 human clinical studies across multiple physiological functions and life stages, including physical performance and recovery, metabolic health, cognition, vision and skin health. "},{"_id":"XGEMWBKZJRC5DHMAGN2REIXJRU","additional_properties":{},"type":"text","content":"Taken together, mechanistic insights and evidence from human studies provide a strong scientific foundation for the use of AstaReal astaxanthin as a multifunctional ingredient in healthspan-oriented product development, linking the biology of ageing with multiple aspects of healthy function across the lifespan."},{"level":3,"_id":"RAWKGC4ZHVGPZIP7TTPHDUNDR4","additional_properties":{},"type":"header","content":"Build around the healthspan objective"},{"_id":"Y7T7GTOJKFDCRKEATBFG4SZHHM","additional_properties":{},"type":"text","content":"This broad scientific foundation also creates flexibility in formulation design. Starting with the intended healthspan objective, developers can identify the biological processes and functional outcomes most relevant to that objective and then build a formulation around them. "},{"_id":"ILCZZPIEWVBPHAUU5WSRJ45ZBA","additional_properties":{},"type":"text","content":"AstaReal astaxanthin can serve as a multifunctional foundation, with complementary ingredients selected to support additional or overlapping biological needs."},{"_id":"6YZDHJOR7JDABI6BKW3P4NMHSY","additional_properties":{},"type":"text","content":"For example, a formulation focused on mobility and muscle function may combine astaxanthin with protein, vitamin D or omega-3 fatty acids, while a vision-focused formulation may incorporate lutein. "},{"_id":"KJ2BOXKVD5BDROF7RWCKVU2ZF4","additional_properties":{},"type":"text","content":"Metabolic or cognitive formulations can similarly be designed around the biology most relevant to their intended outcomes. The aim is to build a rational combination in which complementary ingredients and mechanisms work together toward a clearly defined healthspan objective."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d"},"vanity_credits":{"affiliation":[]},"caption":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/GSP3YNL27RHPTNXXKKR4KQL74A.png","licensable":false,"alt_text":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","width":831,"creditIPTC":"Provided by client","_id":"GSP3YNL27RHPTNXXKKR4KQL74A","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","proxyUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/GSP3YNL27RHPTNXXKKR4KQL74A.png","published":true,"resizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d&width=300","version":0,"originalName":"Figure3.png","mime_type":"image/png","alt_text":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:35:24Z","last_updated_date":"2026-08-21T15:35:24Z","height":303,"image_type":"photograph"},{"level":3,"_id":"DCPHTBEH5ZF4PB5Z6YG2FNZ75M","additional_properties":{},"type":"header","content":"Beyond the ingredient: Effective delivery"},{"_id":"2H65VH2X2FEDRKBXCVA3433G3M","additional_properties":{},"type":"text","content":"Scientific evidence and ingredient selection are only part of translating healthspan science into a successful finished product. Effective delivery also matters. Astaxanthin is naturally lipophilic and is typically formulated in oil-based formats, which can limit its use in other dosage forms. Bioavailability is also an important consideration, as effective absorption depends on how astaxanthin is formulated and delivered."},{"_id":"5ZLJGGHR4FBGBEYFGFVLXHVUBQ","additional_properties":{},"type":"text","content":"AstaReal CLEAR is an astaxanthin emulsion designed to improve dispersibility and enhance bioavailability of astaxanthin<b> </b>by applying delivery technology, while expanding formulation possibilities beyond conventional oil-based capsules."},{"_id":"PVQPIG2XEBAJBJVBNBYVUCVWOI","additional_properties":{},"type":"text","content":"This demonstrates how ingredient science and formulation technology can work together: scientific evidence establishes relevance to the intended healthspan objective, while effective delivery helps translate that evidence into practical and versatile product solutions."},{"level":3,"_id":"6RMPPZ6MBNF2JAMHKF3TRCJUEA","additional_properties":{},"type":"header","content":"Bringing healthspan science into practice"},{"_id":"LOP4CRKZDVBNRFTT2Z3UERH3N4","additional_properties":{},"type":"text","content":"The opportunity in healthspan nutrition is not simply to add more âlongevity ingredientsâ, but to design products around a defined objective, relevant ageing biology, human evidence and practical delivery. AstaReal natural astaxanthin shows what this looks like in practice: a clear mechanistic rationale, a growing body of human research, and a formulation profile that translates into real products. "},{"_id":"QJFZ4AEJZ5HGRL2HOPVWPZ7MHE","additional_properties":{},"type":"text","content":"The combination of robust clinical evidence and versatility across delivery formats is what makes AstaReal astaxanthin a compelling hero ingredient for healthspan-focused development."},{"_id":"2DREQAPMUZEKRHIMCMCUXLGE7U","additional_properties":{},"type":"text","content":"<a href=\"https://astareal.com/en/\" target=\"_blank\" rel=\"\"><b>For more information on AstaReal® Astaxanthin science and its range of products, contact the team here.</b></a>"},{"_id":"XEMGTOFDWZEHLJZLPWHDPHUYMY","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"46Z2YY4EURGUFJFDCWVBU62GJI","type":"list","items":[{"_id":"D3LK6PEUCNF3HMJSNZ5TYC3V5Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"López-OtÃn, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/23746838/\">The hallmarks of aging.</a> Cell. 2013;153(6):1194â1217. "},{"_id":"ZEC7WH7Q6NFYJP3GHUQGQASP3Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"López-OtÃn, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/36599349/\">Hallmarks of aging: An expanding universe.</a> Cell. 2023;186(2):243â278. "},{"_id":"2ZJTRXH4ORFLJJNDWTSSWRSGV4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"World Health Organization. <a href=\"https://www.who.int/news-room/questions-and-answers/item/healthy-ageing-and-functional-ability\">Healthy ageing and functional ability.</a> "},{"_id":"WSZUXL3RBFBFDE6NWALTY375SY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kaufman, MW.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39554957/\">Nutritional Supplements for Healthy Aging: A Critical Analysis Review.</a> Am J Lifestyle Med. 2024;19(3):346â360. "},{"_id":"KZV7PFMVGZHGDDMANR3RWQFATY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Vaiserman, A.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC5520340/\">Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives.</a> J Transl Med. 2017;15:160. "},{"_id":"BVRLWR6SSNGTHPXWFGT4H2PCBQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Nishida, Y.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/32003547/\">Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway.</a> J Cachexia Sarcopenia Muscle. 2020;11(1):241â258. "},{"_id":"22KUATUG2JC7ZP7WKTPO5XONPM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Fu, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/35385370/\">Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism.</a> Nutr Neurosci. 2023;26(5):445â455. "}]}],"subheadlines":{"basic":"How can healthspan nutrition be designed around a defined objective, relevant ageing biology, human evidence and practical delivery?"},"description":{"basic":"How can healthspan nutrition be designed around a defined objective, relevant ageing biology, human evidence and practical delivery?"},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"News","description":"","_id":"/News","additional_properties":{"original":{"parent":{"
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2039,{"_id":"5NEDJ35BOVHQNB4NNFXCJZJQIA","additional_properties":{},"type":"text","content":"The plantâs roots and leaves contain bioactive compounds known as withanolides, which have been studied for their potential role in areas including stress reduction, sleep support, cognitive health, and sports performance. As a result, it is now used widely across supplements, functional foods, and beauty products."},{"_id":"6PJO2VXOUJGRPPXKKQVJUFHIBM","additional_properties":{},"type":"text","content":"Market analysts expect consumer interest in supplements containing the adaptogenic herb to continue to grow, with projections suggesting the category will reach $2.01bn globally by 2035, up from $837.5m in 2025, a CAGR of 9.17%.<sup>1</sup>"},{"_id":"XJCUSORPNRERDHMWR2PJMEYZZY","additional_properties":{},"type":"text","content":"Much of the scientific research surrounding ashwagandha has focused on both the safety of the ingredient, and from a mechanistic perspective, its interaction with the hypothalamic-pituitary-adrenal (HPA) axis, the bodyâs central stressâresponse system. Research has explored the botanicalâs support for stress management, sleep, and cognitive health, although differences in extract composition and standardization approaches remain an ongoing topic of discussion within the category."},{"level":3,"_id":"FUC574ZVOFGUJIEWOPSWCV3C3U","additional_properties":{},"type":"header","content":"Regulatory questions "},{"_id":"RHMVWAC6UBHGHN25ZRE2MSZRYE","additional_properties":{},"type":"text","content":"Alongside its commercial success, ashwagandha is facing intensifying scrutiny from authorities. Concerns have been raised by regulators around long-term safety, potential thyroid and reproductive effects, and uncertainty over safe intake levels. The US National Center for Complementary and Integrative Health has also noted rare cases of liver injury.<sup>2</sup>"},{"_id":"JVTQN3EHCJBFVIG32WY5TIO2QQ","additional_properties":{},"type":"text","content":"Denmark introduced restrictions on ashwagandha in 2023 following concerns around establishing safe intake thresholds. In 2024, national food safety authorities across Europe urged the European Commission to initiate an Article 8 assessment â a move that may confirm ashwagandhaâs safety and reassure national regulators, or potentially lead to EU-wide guidelines or restrictions. "},{"_id":"S2JB43T4UNGA3GG7CI23RM7O6M","additional_properties":{},"type":"text","content":"The TGA in Australia concluded that there was a very rare risk of liver injury with ashwagandha and advises consumers to be aware of potential gastrointestinal adverse effects and the possible risk of liver injury in very rare cases.<sup>3</sup> "},{"_id":"OZ7X7RQ7NRHPXKTP2VPWIIE3E4","additional_properties":{},"type":"text","content":"Industry stakeholders point to variability in extracts with plant part, extraction method, characterization and product specific substantiation all adding to this, creating challenges when comparing products and interpreting resesearch findings.<sup>4</sup> These differences sit at the heart of ongoing discussions around standardization, product quality, and how evidence should be interpreted across the category."},{"_id":"QPOQRZJFGFGNHIB6EDWCY2SRDM","additional_properties":{},"type":"text","content":"For manufacturers, this creates questions around formulation strategy, market access, and future investment decisions. The result is a fragmented landscape where brands must navigate differing national interpretations, evolving safety assessments and extract-specific considerations. "},{"level":3,"_id":"NLGQE7Y5BJA5ZNU4GH3ZSZJQKM","additional_properties":{},"type":"header","content":"Industry response: Clarity, quality, and communication"},{"_id":"3ZUODKC4WFDWXLEFOZAOIF3HW4","additional_properties":{},"type":"text","content":"With regulatory uncertainty mounting, industry stakeholders are stepping forward to address gaps in scientific communication and quality assurance. In May 2026 an industry led initiative, <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, was launched with support from leading manufacturer Kerry, this platform is designed to centralize peer-reviewed research, ensure public access to safety data, provide updates on regulatory developments and a live regulatory tracker outlining permitted uses across global markets."},{"_id":"CDICVCWJCFAQ3D5DR5G3RDNJA4","additional_properties":{},"type":"text","content":"The initiative reflects a broader industry push toward standardization â particularly around withanolide content, extraction methods, analytical testing, and traceability. As the category expands, many stakeholders argue that greater alignment around these will play an important role in supporting consumer trust and regulatory compliance. Indeed, the future of the category may depend on whether industry can build greater alignment."},{"level":3,"_id":"SDXUW3L4UBDELOHZRJCHZ37IAY","additional_properties":{},"type":"header","content":"Join our event"},{"_id":"34PEMIHLJFA3DCSPDMWHEXUUGQ","additional_properties":{},"type":"text","content":"In partnership with Kerry, NutraIngredients is hosting a Spotlight O
2039n <b>â</b>Ashwagandha: Understanding the Science, Scrutiny and Standardsâ. The broadcast will examine whether greater alignment around science, standards, and quality can help the industry navigate regulatory scrutiny to support the categoryâs growth. "},{"level":3,"_id":"FGRANCFHTJFUFHVCJDKTMETLME","additional_properties":{},"type":"header","content":"During the Spotlight broadcast you will:"},{"list_type":"unordered","_id":"4R6JU5VY2BC6XIWXA2INV6V2TU","type":"list","items":[{"_id":"IS2MB4NPDBGRFGMW36S7NAUE4I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Explore the clinical science behind ashwagandha with botanical quality and standardization expert Dr Thomas Brendler. "},{"_id":"A4QQ3FVKTJD7LLKO44J6EFFL5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Gain clarity on the regulatory pressures surrounding the ingredient from food lawyer Dr Mark Tallon. "},{"_id":"WO7XLE6IRJEJXDTTCUVAZYPCXQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how standardization and analytical testing can support greater consistency across botanical products from Petra Erlandson, VP of Sales at Alkemist Labs. "},{"_id":"IXGM5XPNIRFE7ICR3YPK7XXF7I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"See how brands are merging traditional knowledge with modern clinical validation with Dr Laura Collins, RDA Director of Cognitive Health at Kerry."},{"_id":"OASJNY34OVALVA4KGGU27FNULE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how brands are approaching ingredient selection, quality assurance and consumer demand in an increasingly scrutinized category with Jason Watkin, CEO of Canadian wellness brand Purica."}]},{"_id":"QFMPZQK2KVE7TKILJRYKXB7JHU","additional_properties":{},"type":"text","content":"<a href=\"https://tinyurl.com/PrePromoKerry\" target=\"_blank\" rel=\"\" title=\"https://tinyurl.com/PrePromoKerry\"><b>Register now to watch </b><i><b>Ashwagandha: Understanding the Science, Scrutiny and Standards</b></i><b> at 3pm BST, 4pm CEST, 9am CDT on 17 September 2026</b></a>"},{"_id":"B2GOOM25YFEERJNJPNPQNVZAFU","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"TPFA7UOJJRGVPHXX3AZP75YSCM","type":"list","items":[{"_id":"KERK755IVFDZNORE3IUNCPXRX4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pandey, D. <a href=\"https://www.precedenceresearch.com/ashwagandha-market\" target=\"_blank\" rel=\"\" title=\"https://www.precedenceresearch.com/ashwagandha-market\">Ashwagandha Market Size, Share and Trends 2026 to 2035</a>, Precedence Research."},{"_id":"J4W44QJPBVBCLNO7OL4QNTR4V4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"National Center for Complementary and Integrative Health, <a href=\"https://www.nccih.nih.gov/health/ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.nccih.nih.gov/health/ashwagandha\">Health Info, Ashwagandha</a>."},{"_id":"2TDHDVFTRVET5O5HTX3D3SJKFI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Australian Government, Department of Disability, Health and Ageing, <a href=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\">Herbal preparations containing Withania somnifera (Withania, Ashwagandha)</a>."},{"_id":"NWOV3HV2NVH23LHAJMGGOBOOAY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Domián, B. M.; et al. <a href=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\" target=\"_blank\" rel=\"\" title=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\">The ashwagandha paradox: a mixed-methods analysis of regulatory gaps, deceptive vendors and safety risks in the European online market</a>. Applied Food Research, Volume 6, Issue 2, December 2026, 102444."}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent. How can the industry align on science-based standards for quality assurance while ingredient use expands?"},"description":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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2039ort long-term vitality."},{"_id":"XZHTRXHOVRDXJHH7W7FWOX5FD4","additional_properties":{},"type":"text","content":"Within this broader wellness dialogue, lipid management remains a key area of interest. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides and related parameters are frequently monitored as part of a routine health-conscious lifestyle. "},{"_id":"KEY26FFDOZEWJFM67Z5S36U5AM","additional_properties":{},"type":"text","content":"For individuals exploring plant-based options, ingredients that offer amla extract lipid management capabilities have emerged as a topic of considerable interest. Often discussed within the broader context of natural alternatives to statins, these botanical approaches aim to complement a healthy lifestyle rather than replace medical intervention."},{"level":3,"_id":"QX7WEFITUFGEVPE45W2VL2U2BM","additional_properties":{},"type":"header","content":"The science of standardisation: Elevating traditional botanicals"},{"_id":"RXR6S7EVSNA5FCXHAYSVZLDR6M","additional_properties":{},"type":"text","content":"The appeal of traditional botanicals lies in their rich history of use, but modern wellness consumers and product formulators demand a higher standard of proof, consistency and safety. "},{"_id":"3RYDHZDGLBDCZORDTS7HVRLCA4","additional_properties":{},"type":"text","content":"Traditional fruit ingredients can vary widely in composition, making standardisation a crucial step in modern nutraceutical development. Tri-Low â a standardised, natural extract derived from wild-crafted Amla fruit â represents this evolution by transforming a familiar fruit into a reproducible, premium, standardised ingredient to support cardiovascular health."},{"_id":"7Y3GI2ROVVG7DEWY6OUWOAOPQA","additional_properties":{},"type":"text","content":"Derived from fresh, ripe, wild-harvested amla fruit (<i>Phyllanthus emblica</i>), Tri-Low is standardised to contain key bioactives, including triterpenoids, polyphenols and specialised omega-3-related fractions such as alpha-linolenic acid (ALA) and diacylglycerol-bound ALA (DAG-bound ALA). "},{"_id":"EY3VHA5LORDFNAJOVEPSWAEZLY","additional_properties":{},"type":"text","content":"This meticulous standardisation ensures that every batch delivers a consistent profile of active components. For formulators seeking to build science-led wellness products, this level of precision bridges the gap between traditional heritage and modern nutritional science, allowing for a product narrative built on consistency and quality."},{"level":3,"_id":"LIBGP4POCRFBNA7R7MEYIXKKCI","additional_properties":{},"type":"header","content":"Exploring clinical insights and research"},{"_id":"TAPGX4OLERHFNHKBWVKHZZCUQE","additional_properties":{},"type":"text","content":"In the realm of modern nutraceuticals, consumer trust is rooted in transparent research and clinical evaluation. To understand how standardised amla extract interacts with the body, researchers have evaluated its effects in controlled human studies. "},{"_id":"MDR6LEYLGBGR7G6HPYM7IJQYBY","additional_properties":{},"type":"text","content":"For instance, in a randomised, double-blind, placebo-controlled multicentre study involving 98 participants, the administration of Tri-Low at 500 mg twice daily over a 12-week period was observed to support healthy lipid parameters.<sup>1</sup>"},{"_id":"WE3QNDZU7FFO5OXPYJU4YLJ6RY","additional_properties":{},"type":"text","content":"The study noted several observable improvements in key markers among the participant cohort:"},{"header":[{"_id":"BFZKK7JQ4VA5JPTG3TDWK4M67I","type":"text","content":"Evaluated parameter"},{"_id":"STET7WNSLJAUHMJB7ERL5L2NGY","type":"text","content":"Observed study findings (12 Weeks)"}],"_id":"QBQ7F7RUQVFHNAHQCY52WPFRGA","additional_properties":{},"rows":[[{"_id":"KF3WKYDLHFFINMPSH742YLWL5E","type":"text","content":"LDL cholesterol (LDL-C)"},{"_id":"K3EVCR2DDNCELBTWQOX2LB6JHU","type":"text","content":"Observed average reduction of up to 20% in evaluated participants"}],[{"_id":"I7XMTIA2X5DN3DQGEJVJQHJICA","type":"text","content":"Triglyceride levels"},{"_id":"NABQYOQFPZAQLJUFQPD523S5RQ","type":"text","content":"Observed average decrease of up to 34% in study cohorts"}],[{"_id":"RMOYOAEKAZDS7HUIR674YZ77FY","type":"text","content":"Total cholesterol"},{"_id":"IOAMIQ5NOZDXDJI66EDLXAZ4UE","type":"text","content":"Observed average decrease of up to 24% in evaluated participants"}]],"type":"table"},{"_id":"GSYS5H5IXNAP3KTKI3NCMSHGRE","additional_properties":{},"type":"text","content":"The results indicate positive observations related to broader atherogenic markers, contributing to a more comprehensive understanding of cardiovascular nutrition. In separate clinical investigations, standardised amla extract was also evaluated for its broader metabolic relevance, noting associations with parameters such as body weight, waist circumference, body fat percentage, visceral fat distribution, skeletal muscle mass and biological body age.<sup>2</sup> "},{"_id":"O74BEFQOINEH5P3KJOQBOFRPIM","additional_properties":{},"type":"text","content":"These observations suggest that a standardised amla extract can serve as a supportive element in comprehensive wellness routines that address both lipid balance and broader metabolic harmony."},{"level":3,"_id":"BJTKXFSM5NBRXKGMFXS7BQNXJM","additional_properties":{},"type":"header","content":"Prioritising safety and consumer confidence"},{"_id":"KLP73UCHSZA6VFVXZZLM55CZGE","additional_properties":{},"type":"text","content":"When introducing any botanical ingredient into a daily wellness routine, safety is paramount. Consumers and formulators alike require assurance that a natural extract is safe for regular, long-term consumption. To establish this baseline of trust, Tri-Low underwent rigorous toxicological evaluations, including acute toxicity testing under OECD 423 guidelines and sub-chronic toxicity testing under OECD 408 guidelines.<sup>3</sup>"},{"_id":"BIAPYDLPTVGWRAY4XD67OFZFTQ","additional_properties":{},"type":"text","content":"In these repeated-dose studies, the evaluations revealed no visible adverse effects, even at extrapolated human-equivalent intake levels significantly higher than typical recommended servings. This robust safety profile provides valuable peace of mind for both formulators designing consumer products and individuals incorporating the ingredient into their daily wellness regimens. "},{"_id":"ZOZSDIDQNNE37OIOBK4BQ4F74A","additional_properties":{},"type":"text","content":"By combining a clearly defined bioactive composition, supportive clinical research and documented safety standards, standardised amla extract represents a trustworthy choice in contemporary nutraceutical formulation."},{"level":3,"_id":"GPP5EIA7CZFENE2V3XJVMCHWHE","additional_properties":{},"type":"header","content":"A feel-good approach to heart-health communications"},{"_id":"F2N56FUZJRFMNCKHTQUEWYVLIE","additional_properties":{},"type":"text","content":"Crafting a positive and uplifting narrative around heart health is essential for inspiring lasting lifestyle changes. Rather than focusing on fear or restrictive measures, modern wellness communications thrive on a feel-good factor â emphasising vitality, self
2039-care and the empowering choice to nourish the body with scientifically supported natural ingredients. "},{"_id":"7GWPRJDMCJCUZPW64UYRLHX524","additional_properties":{},"type":"text","content":"Tri-Low embodies this positive philosophy by connecting a familiar, cherished botanical with modern scientific validation."},{"_id":"Z55DFSO4URECNBM6F6QKQ4CDEY","additional_properties":{},"type":"text","content":"It bridges the gap between personal wellness goals and global nutritional standards, offering a harmonious blend of heritage and data. For brands looking to craft transparent, engaging, and science-led communications, standardized amla extract provides a compelling story of natural balance and vitality."},{"_id":"SYHVBPS3NVHYNACXA4LP7T3M7U","additional_properties":{},"type":"text","content":"<b>Exploring further</b>"},{"_id":"L2H2MNY3TRGMJJG7EUI5ENRC2Y","additional_properties":{},"type":"text","content":"For those interested in delving deeper into the scientific evaluations, bioactive profiles and research methodologies surrounding standardised amla extract, <a href=\"https://arjunanatural.com/cardiovascular-health-2/\" target=\"_blank\" rel=\"\">download the whitepaper on comprehensive lipid management here.</a> "},{"_id":"ALRO5YQICVAEXCNLCPILHIHUDA","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"N4JYHPIKZFDBFF7XXQ3REUUII4","type":"list","items":[{"_id":"E3WTK34RSRGMVP2Y3FVAJLCCLA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Upadya H.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/30670010/\" target=\"_blank\" rel=\"\">A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia.</a> BMC Complement Altern Med. 2019 Jan 22;19(1):27. "},{"_id":"WSL3TJ4RSRCKJLTZWOLQONFORM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Suhag, D.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC13148805/\" target=\"_blank\" rel=\"\">Effect of Amla Extract on Body Mass Index, Waist Circumference, Total Body Fat, Visceral Fat, Skeletal Mu
2039scle Mass, Body Age, and Related Parameters: A Randomized, Open-Label Clinical Study in Obese Participants.</a> Complementary Medicine Research. 2025; 32.4: 326-340."},{"_id":"62HMSQ5QSNDJXNMPYOEUOTHTJU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Benny, M.; et al. <a href=\"https://rjptonline.org/AbstractView.aspx?PID=2024-17-10-37\" target=\"_blank\" rel=\"\">Safety Evaluation of Amla extract by Acute and Sub-chronic exposure in rats</a>. Research Journal of Pharmacy and Technology 17, no. 10 (2024): 4887-4894."}]}],"subheadlines":{"basic":"Standardised amla extract may provide support for cardiovascular health, new study shows."},"description":{"basic":"Standardised amla extract may provide support for cardiovascular health, new study shows."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all c
2039omes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve communication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
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2039its, with implications for healthy aging, metabolic health, and inflammatory balance.</b>"},{"_id":"A5OYF4HX4VG7TJJ7ZQNBEEIS4M","additional_properties":{},"type":"text","content":"Fisetin has never lacked scientific interest. The flavonoid, found naturally in strawberries, apples, and onions, has attracted sustained attention for its antioxidant and anti-inflammatory activity and, more recently, for its senolytic properties: the ability to help clear senescent cells."},{"_id":"266MUNKUSRBAHL3CTW7LDULPHQ","additional_properties":{},"type":"text","content":"What it has lacked is human evidence. Most of the excitement around fisetin has come from cell and animal work, and for an ingredient with commercial ambitions, that gap matters. This year it began to close, with two papers from the 12-week randomised controlled trial in men with obesity, tracking a broad set of inflammatory and metabolic biomarkers at 200 mg/day of fisetin."},{"_id":"CJHFBANIU5HWVLJA3Y6VJAJ44E","additional_properties":{},"type":"text","content":"The results do not make fisetin a treatment for obesity or metabolic disease. Their value to the nutrition industry lies elsewhere: fisetinâs story is moving from cell cultures to measurable human outcomes across more than one dimension of healthy aging."},{"level":3,"_id":"7ABSYPQZCNFZ7AWXXHGQ6YEJTA","additional_properties":{},"type":"header","content":"From senescent cells to human health"},{"_id":"5UH7GQIVHFEQRKOXKI6242AQF4","additional_properties":{},"type":"text","content":"Much of fisetinâs recent reputation rests on cellular senescence. Senescent cells stop dividing but stay metabolically active, releasing signaling molecules that affect the tissue around them. Their accumulation is a central theme in aging biology, and it has made fisetin one of the best-known botanical candidates in the emerging senolytic field."},{"_id":"2GKPJMRI6FALJP2XIW64H2KSOA","additional_properties":{},"type":"text","content":"For supplement brands, the opportunity may extend further. Healthy aging is increasingly treated as a multidimensional target: metabolic resilience, inflammatory balance, physical function, healthspan. Ingredients whose biology plausibly connects to several of those dimensions have an edge, and the 2026 papers put fisetin firmly in that conversation."},{"level":3,"_id":"BI5AKJ33HNCJZMGKZLHIYFIECY","additional_properties":{},"type":"header","content":"What the fisetin human trial found"},{"_id":"AX24UWORKZHYTJAFNZ7YK6ESIY","additional_properties":{},"type":"text","content":"Trialists at Hakim Sabzevari University and collaborating institutions randomized sedentary men with obesity into four arms: fisetin alone (200 mg/day), interval resistance-aerobic training alone, both combined, or placebo, for 12 weeks. Two papers from the clinical trial appeared this year, each covering a different set of biomarkers."},{"_id":"37ZFIUSWSBBZRI5RF4SVZYMCC4","additional_properties":{},"type":"text","content":"The first paper, published in <i>Nutrients</i>, tracked adipokines and lipid-related markers, including asprosin, MCP-1, and adiponectin. The largest changes appeared in the combined fisetin-plus-training arm, with meaningful reductions in asprosin and MCP-1 alongside improved lipid measures; fisetin alone also produced changes on several of these markers, though generally smaller than the combined arm.<sup>1</sup>"},{"_id":"ZHXBX2LMWBFHJBIJPFBHFX44WI","additional_properties":{},"type":"text","content":"The second paper, in the <i>Journal of the International Society of Sports Nutrition</i>, examined a different part of the biology: Maresin-1, a specialised pro-resolving mediator involved in resolving inflammation rather than simply suppressing it, alongside IL-6, TNF-α, fasting glucose, insulin, and HOMA-IR.<sup>2</sup>"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]}
2039,"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/URUUQOKCBBBS3CIR6L2EGV35ZM.png","licensable":false,"alt_text":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","width":2000,"creditIPTC":"Provided by client","_id":"URUUQOKCBBBS3CIR6L2EGV35ZM","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","proxyUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/URUUQOKCBBBS3CIR6L2EGV35ZM.png","published":true,"resizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/URUUQOKCBBBS3CIR6L2EGV35ZM.png?auth=0f6a42947c2601ffce7dbfec8e87425178602960f8593273c0087ad5d30e3ed6&width=300","version":0,"originalName":"Figure-1.png","mime_type":"image/png","alt_text":"Bar charts from the 2026 fisetin human trial: asprosin, MCP-1, adiponectin and Maresin-1 across four arms at a fisetin dosage of 200 mg/day","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T08:39:29Z","last_updated_date":"2026-09-11T08:39:29Z","height":1315,"image_type":"photograph"},{"_id":"NUXIWGQQ3FCIBAHCT5KV7ZM6DY","additional_properties":{},"type":"text","content":"The group-by-time interaction for Maresin-1 was statistically significant, but the rise was confined to the two training arms (with and without fisetin), suggesting this particular resolution pathway needs an exercise stimulus to activate. IL-6 fell significantly in both training groups and in the fisetin-alone group, while the combined arm again produced the broadest pattern of improvement, extending to TNF-α, fasting glucose, insulin, and HOMA-IR."},{"_id":"GRCGTKCR5VGJPIEOD2GZEONK7A","additional_properties":{},"type":"text","content":"Read together, the two papers sketch a coherent, and appropriately nuanced, picture: fisetin has some independent activity on inflammatory and metabolic markers, but its most consistent and largest effects appear alongside training, and at least one specific pathway â Maresin-1-driven inflammation resolution â seems to depend on exercise rather than fisetin itself. "},{"_id":"KWBORRXD4JFMLJ5G7IUYNQXWSQ","additional_properties":{},"type":"text","content":"Whether fisetin genuinely amplifies the benefits of training, rather than simply adding to them through a separate mechanism, is a question this trial wasnât designed to isolate. Thatâs a sensible hypothesis for the next study to test directly, not a settled conclusion to market around."},{"level":3,"_id":"MRBQSKCSMZG3HMIHGNRWIFT52Y","additional_properties":{},"type":"header","content":"Why these fisetin benefits matter "},{"_id":"LZ6YUX5AGZA7PD5NXVO7OJGK3E","additional_properties":{},"type":"text","content":"For the industry, the interesting question is not just what fisetin is good for today, but what kind of ingredient it could become if this evidence base keeps building."},{"_id":"XCACYRQKWVA6BGA7HYBZIPF35Y","additional_properties":{},"type":"text","content":"The market has moved past the idea that healthy aging means stacking antioxidants into a formula. Todayâs longevity consumer wants to stay metabolically healthy and functional for longer. That opens at least four application territories for fisetin."},{"_id":"6DCYY5YKRRCFNN3VDQC2UCV3HU","additional_properties":{},"type":"text","content":"<b>Cellular longevity: </b>This remains fisetinâs most distinctive ground. Its link to senescence research gives it a position in the longevity category that conventional antioxidants cannot easily copy."},{"_id":"LL5KDB4YNJGSDIEHHONN5R7SBQ","additional_properties":{},"type":"text","content":"<b>Healthy aging: </b>The senescence story bridges naturally into formulations aimed at maintaining cellular and systemic health over time."},{"_id":"3QGPCXOZ5RAWDF72QHLIVF5MMI","additional_properties":{},"type":"text","content":"<b>Metabolic health: </b>
2039The 2026 data touch adipokines, lipids, glucose, insulin, and HOMA-IR, all central to the fast-growing metabolic health category. That is not grounds to position fisetin as a standalone weight-management ingredient. The more defensible proposition is supporting healthy metabolic function within a broader healthy-aging strategy, one that includes physical activity."},{"_id":"QQDTV44VYNDTPIV47DVEEEJ2DY","additional_properties":{},"type":"text","content":"<b>Inflammatory balance: </b>The Maresin-1 finding points beyond simply lowering inflammatory markers, towards how an ingredient interacts with the bodyâs own resolution machinery. It is a narrative the category has barely claimed."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg","licensable":false,"alt_text":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","width":1500,"creditIPTC":"Provided by client","_id":"3ZAEMGW7WJHKFJE25EC3GAXC5Q","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","proxyUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg","published":true,"resizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/3ZAEMGW7WJHKFJE25EC3GAXC5Q.jpg?auth=2f84460cb3c6e8e403d0c83a5c34883bf4d1e07e4f996b67f229b6d1d4ea248f&width=300","version":0,"originalName":"Figure-2.jpg","mime_type":"image/jpeg","alt_text":"What fisetin is good for: four application territories, from senolytic cellular longevity to healthy aging, metabolic health and inflammatory balance","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T08:40:08Z","last_updated_date":"2026-09-11T08:40:08Z","height":927,"image_type":"photograph"},{"level":3,"_id":"YJ7B5G67XNGFTEC6CLPM5XZSJE","additional_properties":{},"type":"header","content":"Better science raises the bar for the ingredient"},{"_id":"UQJ6ZMNM5NEPNLAOTYSPMUQKAA","additional_properties":{},"type":"text","content":"A stronger research story cuts both ways. As fisetin becomes commercially attractive, the ingredient itself faces harder questions. Formulators are no longer asking only whether fisetin has interesting biology; they want to know whether they can source it with the quality, consistency, safety documentation, and evidence needed to build a credible product."},{"_id":"SNFSVQDLL5DVPA3CAJJSHLSMWY","additional_properties":{},"type":"text","content":"The fisetin in a clinical trial is a defined research intervention. A commercial ingredient has to deliver reproducible specifications, controlled purity, a characterized impurity profile and a proper safety dossier, plus human evidence tied to the material being sold. As the healthy-aging category matures, that gap between a promising molecule and a commercial-grade ingredient will draw more scrutiny, not less."},{"level":3,"_id":"SJRM4CRFAZDNLLETZTY7DH523E","additional_properties":{},"type":"header","content":"The next stage of fisetin science"},{"_id":"6N22Y7LBC5HZ3IA5BCXO5CLWGU","additional_properties":{},"type":"text","content":"This is the gap BeFisetin®, developed by Bonerge, is built to close. The fisetin powder pairs a defined specification with its own safety and clinical research foundation: more than 99% active content and less than 1% total impurities, by the companyâs reported specifications."},{"_id":"AUGW7VLICNGSHLXYNHA7UFQ3F4","additional_properties":{},"type":"text","content":"On safety, BeFisetin carries a Self-Affirmed GRAS (SA-GRAS) status, meaning an independent panel of qualified experts has concluded that the ingredient meets the âGenerally Recognized As Safeâ, standard under US law."},{"_id":"JX66Y6XP4BCRLLHWKNGJPUYDEM","additional_properties":{},"type":"text","content":"The bigger differentiator is the effort to connect ingredient quality with human evidence. In a completed clinical study in skin health, BeFisetin supplementation produced improvements in skin barrier function, elasticity, and the appearance of wrinkles â outcomes that sit inside one of the most established beauty-from-within categories. "},{"_id":"LWTCAHA65RB33OACCM22UDKSOM","additional_properties":{},"type":"text","content":"A second study is now underway in sleep health: a randomized, quadruple-blind, placebo-controlled trial (NCT06990256), evaluating BeFisetin alone and in combination with StanYouth urolithin A over 12 weeks in more than 80 middle-aged and older adults, with sleep quality and aging biomarkers as core readouts."}
2039,{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"7d13f980279f9bea7bffaa6e6210aad6ec2f562e04020ddb161dc7ecdcb85706"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg","licensable":false,"alt_text":"Two clinical studies on BeFisetin fisetin powder by Bonerge: a completed skin benefits study and an ongoing sleep trial, NCT06990256, both at 500 mg/day","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Two clinical studies on BeFisetin fisetin powder by Bonerge: a completed skin benefits study and an ongoing sleep trial, NCT06990256, both at 500 mg/day","width":1300,"creditIPTC":"Provided by client","_id":"PDU5C77TIJEYVHQFHG4BDN5EKE","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg?auth=7d13f980279f9bea7bffaa6e6210aad6ec2f562e04020ddb161dc7ecdcb85706","proxyUrl":"/resizer/v2/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg?auth=7d13f980279f9bea7bffaa6e6210aad6ec2f562e04020ddb161dc7ecdcb85706","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg","published":true,"resizeUrl":"/resizer/v2/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg?auth=7d13f980279f9bea7bffaa6e6210aad6ec2f562e04020ddb161dc7ecdcb85706","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/PDU5C77TIJEYVHQFHG4BDN5EKE.jpg?auth=7d13f980279f9bea7bffaa6e6210aad6ec2f562e04020ddb161dc7ecdcb85706&width=300","version":0,"originalName":"Figure-3.jpg","mime_type":"image/jpeg","alt_text":"Two clinical studies on BeFisetin fisetin powder by Bonerge: a completed skin benefits study and an ongoing sleep trial, NCT06990256, both at 500 mg/day","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T08:40:55Z","last_updated_date":"2026-09-11T08:40:55Z","height":845,"image_type":"photograph"},{"_id":"QHRNCM5M2ZEZFCK3YI2O7ZQK4A","additional_properties":{},"type":"text","content":"Together, the two studies give BeFisetin a clinical program of its own, targeting healthspan-relevant outcomes where consumer demand already exists, rather than relying solely on evidence generated with generic fisetin. "},{"_id":"MIZZ5PEXTZBZHO6BQHOQI5ASNA","additional_properties":{},"type":"text","content":"For brands, that matters practically: high purity and a controlled impurity profile make formulation and finished-product specification easier to stand behind, and a proprietary clinical pipeline gives the finished product a story beyond ingredient-level trend momentum."},{"level":3,"_id":"O75EICG2XJFJNHT4NKWFDTWHXU","additional_properties":{},"type":"header","content":"What comes next"},{"_id":"V27KBHG6CJEPZM5JMNKIV2BTJA","additional_properties":{},"type":"text","content":"The 2026 papers mark the point at which fisetinâs human evidence began to catch up with its preclinical reputation. The open questions are clear: larger and longer trials, broader populations, optimal fisetin dosage, and a direct test of whether fisetin amplifies exercise-driven benefits. "},{"_id":"ZHUUVHXTWRHPRL4WL2JOPMFOF4","additional_properties":{},"type":"text","content":"If future work keeps connecting fisetin to senescence, inflammation resolution, and metabolic health, the ingredient could occupy a rare position across several major supplement trends at once."},{"_id":"FSY44TXQHJH3TEFL4RA2IHW5IU","additional_properties":{},"type":"text","content":"For the industry, the task is to work out whether fisetin can become a genuine platform ingredient for healthy aging, and whether suppliers can bring the rigor, purity, safety documentation, and proprietary evidence that transition demands. "},{"_id":"D4LKQXTQBZCLJCKQQIYLWM4KOQ","additional_properties":{},"type":"text","content":"That bar is rising. The ingredients that can meet it, with data precise enough to survive scrutiny, are the ones most likely to define what this category becomes."},{"_id":"PKSQHERT7JEIVE7TJON3GNWJT4","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"AJ4EQSAQWVC7FP5VFQHPXWLB2E","type":"list","items":[{"_id":"6PA6ZUQISRC5VFAG5YHQKRMB6M","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Alipour, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/41683255/\">The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. </a>Nutrients. 2026;18(3):433. "},{"_id":"P4DHDAS4OJHGPAYQKNOBHRGNGI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Alipour, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/42218768/\">12âweeks fisetin supplementation and interval resistance with aerobic training: changes in Maresinâ1 and inflammatory markers in men with obesity: a randomized controlled trial. </a>J Int Soc Sports Nutr. 2026;23(1):2679718. "}]}],"subheadlines":{"basic":"Two publications from a 2026 randomized controlled trial add human evidence on fisetin supplement benef
2039its, with implications for healthy aging, metabolic health, and inflammatory balance."},"description":{"basic":"Two publications from a 2026 randomized controlled trial add human evidence on fisetin supplement benefits, with implications for healthy aging, metabolic health, and inflammatory balance."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner 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2039,{"_id":"5NEDJ35BOVHQNB4NNFXCJZJQIA","additional_properties":{},"type":"text","content":"The plantâs roots and leaves contain bioactive compounds known as withanolides, which have been studied for their potential role in areas including stress reduction, sleep support, cognitive health, and sports performance. As a result, it is now used widely across supplements, functional foods, and beauty products."},{"_id":"6PJO2VXOUJGRPPXKKQVJUFHIBM","additional_properties":{},"type":"text","content":"Market analysts expect consumer interest in supplements containing the adaptogenic herb to continue to grow, with projections suggesting the category will reach $2.01bn globally by 2035, up from $837.5m in 2025, a CAGR of 9.17%.<sup>1</sup>"},{"_id":"XJCUSORPNRERDHMWR2PJMEYZZY","additional_properties":{},"type":"text","content":"Much of the scientific research surrounding ashwagandha has focused on both the safety of the ingredient, and from a mechanistic perspective, its interaction with the hypothalamic-pituitary-adrenal (HPA) axis, the bodyâs central stressâresponse system. Research has explored the botanicalâs support for stress management, sleep, and cognitive health, although differences in extract composition and standardization approaches remain an ongoing topic of discussion within the category."},{"level":3,"_id":"FUC574ZVOFGUJIEWOPSWCV3C3U","additional_properties":{},"type":"header","content":"Regulatory questions "},{"_id":"RHMVWAC6UBHGHN25ZRE2MSZRYE","additional_properties":{},"type":"text","content":"Alongside its commercial success, ashwagandha is facing intensifying scrutiny from authorities. Concerns have been raised by regulators around long-term safety, potential thyroid and reproductive effects, and uncertainty over safe intake levels. The US National Center for Complementary and Integrative Health has also noted rare cases of liver injury.<sup>2</sup>"},{"_id":"JVTQN3EHCJBFVIG32WY5TIO2QQ","additional_properties":{},"type":"text","content":"Denmark introduced restrictions on ashwagandha in 2023 following concerns around establishing safe intake thresholds. In 2024, national food safety authorities across Europe urged the European Commission to initiate an Article 8 assessment â a move that may confirm ashwagandhaâs safety and reassure national regulators, or potentially lead to EU-wide guidelines or restrictions. "},{"_id":"S2JB43T4UNGA3GG7CI23RM7O6M","additional_properties":{},"type":"text","content":"The TGA in Australia concluded that there was a very rare risk of liver injury with ashwagandha and advises consumers to be aware of potential gastrointestinal adverse effects and the possible risk of liver injury in very rare cases.<sup>3</sup> "},{"_id":"OZ7X7RQ7NRHPXKTP2VPWIIE3E4","additional_properties":{},"type":"text","content":"Industry stakeholders point to variability in extracts with plant part, extraction method, characterization and product specific substantiation all adding to this, creating challenges when comparing products and interpreting resesearch findings.<sup>4</sup> These differences sit at the heart of ongoing discussions around standardization, product quality, and how evidence should be interpreted across the category."},{"_id":"QPOQRZJFGFGNHIB6EDWCY2SRDM","additional_properties":{},"type":"text","content":"For manufacturers, this creates questions around formulation strategy, market access, and future investment decisions. The result is a fragmented landscape where brands must navigate differing national interpretations, evolving safety assessments and extract-specific considerations. "},{"level":3,"_id":"NLGQE7Y5BJA5ZNU4GH3ZSZJQKM","additional_properties":{},"type":"header","content":"Industry response: Clarity, quality, and communication"},{"_id":"3ZUODKC4WFDWXLEFOZAOIF3HW4","additional_properties":{},"type":"text","content":"With regulatory uncertainty mounting, industry stakeholders are stepping forward to address gaps in scientific communication and quality assurance. In May 2026 an industry led initiative, <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, was launched with support from leading manufacturer Kerry, this platform is designed to centralize peer-reviewed research, ensure public access to safety data, provide updates on regulatory developments and a live regulatory tracker outlining permitted uses across global markets."},{"_id":"CDICVCWJCFAQ3D5DR5G3RDNJA4","additional_properties":{},"type":"text","content":"The initiative reflects a broader industry push toward standardization â particularly around withanolide content, extraction methods, analytical testing, and traceability. As the category expands, many stakeholders argue that greater alignment around these will play an important role in supporting consumer trust and regulatory compliance. Indeed, the future of the category may depend on whether industry can build greater alignment."},{"level":3,"_id":"SDXUW3L4UBDELOHZRJCHZ37IAY","additional_properties":{},"type":"header","content":"Join our event"},{"_id":"34PEMIHLJFA3DCSPDMWHEXUUGQ","additional_properties":{},"type":"text","content":"In partnership with Kerry, NutraIngredients is hosting a Spotlight O
2039n <b>â</b>Ashwagandha: Understanding the Science, Scrutiny and Standardsâ. The broadcast will examine whether greater alignment around science, standards, and quality can help the industry navigate regulatory scrutiny to support the categoryâs growth. "},{"level":3,"_id":"FGRANCFHTJFUFHVCJDKTMETLME","additional_properties":{},"type":"header","content":"During the Spotlight broadcast you will:"},{"list_type":"unordered","_id":"4R6JU5VY2BC6XIWXA2INV6V2TU","type":"list","items":[{"_id":"IS2MB4NPDBGRFGMW36S7NAUE4I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Explore the clinical science behind ashwagandha with botanical quality and standardization expert Dr Thomas Brendler. "},{"_id":"A4QQ3FVKTJD7LLKO44J6EFFL5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Gain clarity on the regulatory pressures surrounding the ingredient from food lawyer Dr Mark Tallon. "},{"_id":"WO7XLE6IRJEJXDTTCUVAZYPCXQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how standardization and analytical testing can support greater consistency across botanical products from Petra Erlandson, VP of Sales at Alkemist Labs. "},{"_id":"IXGM5XPNIRFE7ICR3YPK7XXF7I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"See how brands are merging traditional knowledge with modern clinical validation with Dr Laura Collins, RDA Director of Cognitive Health at Kerry."},{"_id":"OASJNY34OVALVA4KGGU27FNULE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how brands are approaching ingredient selection, quality assurance and consumer demand in an increasingly scrutinized category with Jason Watkin, CEO of Canadian wellness brand Purica."}]},{"_id":"QFMPZQK2KVE7TKILJRYKXB7JHU","additional_properties":{},"type":"text","content":"<a href=\"https://tinyurl.com/PrePromoKerry\" target=\"_blank\" rel=\"\" title=\"https://tinyurl.com/PrePromoKerry\"><b>Register now to watch </b><i><b>Ashwagandha: Understanding the Science, Scrutiny and Standards</b></i><b> at 3pm BST, 4pm CEST, 9am CDT on 17 September 2026</b></a>"},{"_id":"B2GOOM25YFEERJNJPNPQNVZAFU","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"TPFA7UOJJRGVPHXX3AZP75YSCM","type":"list","items":[{"_id":"KERK755IVFDZNORE3IUNCPXRX4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pandey, D. <a href=\"https://www.precedenceresearch.com/ashwagandha-market\" target=\"_blank\" rel=\"\" title=\"https://www.precedenceresearch.com/ashwagandha-market\">Ashwagandha Market Size, Share and Trends 2026 to 2035</a>, Precedence Research."},{"_id":"J4W44QJPBVBCLNO7OL4QNTR4V4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"National Center for Complementary and Integrative Health, <a href=\"https://www.nccih.nih.gov/health/ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.nccih.nih.gov/health/ashwagandha\">Health Info, Ashwagandha</a>."},{"_id":"2TDHDVFTRVET5O5HTX3D3SJKFI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Australian Government, Department of Disability, Health and Ageing, <a href=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\">Herbal preparations containing Withania somnifera (Withania, Ashwagandha)</a>."},{"_id":"NWOV3HV2NVH23LHAJMGGOBOOAY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Domián, B. M.; et al. <a href=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\" target=\"_blank\" rel=\"\" title=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\">The ashwagandha paradox: a mixed-methods analysis of regulatory gaps, deceptive vendors and safety risks in the European online market</a>. Applied Food Research, Volume 6, Issue 2, December 2026, 102444."}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent. 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2039,{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg","licensable":false,"alt_text":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","width":1920,"creditIPTC":"Provided by client","_id":"N5R6EVCMGNEGVPFEEMNOSSGQZQ","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","proxyUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg","published":true,"resizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/N5R6EVCMGNEGVPFEEMNOSSGQZQ.jpg?auth=65f2e15e3f85701407baaddd781de34edf8e0fccd9e979f0769e5e49d6807ea8&width=300","version":0,"originalName":"Figure-1.jpg","mime_type":"image/jpeg","alt_text":"Comparison graphic contrasting traditional Sleep Aid (melatonin, sedation-focused, single pathway) with next-generation Sleep Recovery (circadian rhythm, gut-brain axis, whole-body recovery)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:42:06Z","last_updated_date":"2026-08-13T10:42:06Z","height":960,"image_type":"photograph"},{"level":3,"_id":"I3X7Y76FPBAPDKSXFF6CJPNTT4","additional_properties":{},"type":"header","content":"Sleep health is becoming more than sleep initiation"},{"_id":"UGFWKRNS6VGFLOMC32WGYP67XI","additional_properties":{},"type":"text","content":"For decades, sleep supplements followed a relatively straightforward development strategy. Most products focused on one of three approaches:"},{"list_type":"unordered","_id":"VYKSNYCXRRGZJPX7MTIWV6PLUQ","type":"list","items":[{"_id":"5H5NX36UGNHIVCA5MBTPZ63RPI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Supporting circadian rhythm "},{"_id":"7CXNGMMAFFGGVPA56RB3GSHXAQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Promoting relaxation "},{"_id":"PBT6QI4NBZDQXFKIVFUQT3FJ2E","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Reducing nighttime nervous system activity "}]},{"_id":"RVUPBVWYTNC77KF7VEI6NHQUKQ","additional_properties":{},"type":"text","content":"Melatonin naturally became the dominant ingredient because it directly addressed sleep onset. Todayâs consumers, however, are grappling with sleep challenges that go well beyond simply falling asleep, including:"},{"list_type":"unordered","_id":"JCVZDPYF4FCB3LHJLVL6A6FCWA","type":"list","items":[{"_id":"H5O46GH3NJHUFLVS2SVJ4JVZGY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Fragmented sleep "},{"_id":"Z2LYO3UGT5CXLAHS6NJ57E35FU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Frequent nighttime awakenings"},{"_id":"VPTELN3NQ5CL3LJBZMNKPXQFOI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Light sleep"},{"_id":"CILK3CPGQFCO5PPVXJETK5XG24","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Early morning waking"},{"_id":"M3JWAMX6RBHLNGMZFQ7DGRTAVQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Waking up feeling unrefreshed de
2039spite sleeping for seven or eight hours "}]},{"_id":"TAOSFISBXVANDD6IL5YSBEX2NI","additional_properties":{},"type":"text","content":"These patterns are rarely driven by a single pathway. Instead, sleep quality is increasingly understood as the outcome of multiple interconnected physiological systems, including circadian biology, neurochemical balance, inflammation, metabolism, and age-related changes."},{"_id":"6LSFF5UV6ZB3RG5EJDBZ3YRP5Q","additional_properties":{},"type":"text","content":"Consequently, product innovation is evolving. Rather than relying on a single ingredient, many companies are developing multi-mechanism formulations designed to support both sleep quality and overnight recovery. "},{"_id":"D7MCZXIICBGFBCWVEGBZ56VMVM","additional_properties":{},"type":"text","content":"Natrolâs Sleep & Restore⢠portfolio illustrates this transition well, combining GABA, magnesium, vitamin B6, and botanical ingredients to support relaxation while expanding the product narrative beyond simply helping consumers fall asleep."},{"_id":"THYJZHCZ75FQDDIGRUHMVRX5TI","additional_properties":{},"type":"text","content":"The underlying message is becoming increasingly clear: sleep is no longer viewed as a single neurological event â it is increasingly recognized as a whole-body recovery process."},{"level":3,"_id":"FLPZSQSMGRGXNPZL764WTLXM5E","additional_properties":{},"type":"header","content":"Beyond relaxation: Where will non-melatonin innovation go next?"},{"_id":"AIUIOG65SZF5TEFP2RFFR6ABHE","additional_properties":{},"type":"text","content":"The first generation of non-melatonin sleep products largely replaced melatonin with alternative mechanisms."},{"_id":"FWCGUSBTRZD4ZDB77EQACWGICI","additional_properties":{},"type":"text","content":"Ingredients such as GABA, L-theanine, and magnesium became the categoryâs leading alternatives because they help regulate neuronal excitability and promote relaxation. Each has a well-established scientific rationale:"},{"list_type":"unordered","_id":"5YN2QNCCYZA7JJYNK3F37CVB5Q","type":"list","items":[{"_id":"ZWI5HVBXX5HCZLW2O55WCRO2UE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>GABA</b> supports inhibitory neurotransmission and helps reduce neuronal activity.<sup>2</sup>"},{"_id":"FIDXRXFKINBFDLHJ5BGSBWK2IE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>Magnesium</b> contributes to neuromuscular function and helps regulate excitatory neurotransmission.<sup>3</sup>"},{"_id":"I3XSOJVT25ENFIWYN22AL4KK54","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"<b>L-theanine</b> has been studied for its ability to promote alpha brain wave activity associated with a relaxed mental state.<sup>4</sup>"}]},{"_id":"6O5PA6N6QRC2NCR2XYNEVY53AU","additional_properties":{},"type":"text","content":"These ingredients remain highly valuable. However, they largely address the same biological objective: reducing nervous system activation."},{"_id":"67PVAMFRC5C4RL4HYIDTPGU4QI","additional_properties":{},"type":"text","content":"This raises an important question for the future of sleep product innovation. If every non-melatonin formulation ultimately focuses on calming the nervous system, the market risks returning to familiar competitive territory â faster onset, stronger effects, or more noticeable sensations."},{"_id":"VMHYXYHLUZATHE6ZKZVDN7IERM","additional_properties":{},"type":"text","content":"Yet consumers are asking a different question: why has my sleep quality deteriorated in the first place?"},{"_id":"GIKCJCLC4FDCXNJO4PYS3J2IGA","additional_properties":{},"type":"text","content":"Answering that question requires expanding beyond neurotransmitters to examine the broader physiological environment influencing sleep. One of the most promising scientific frameworks emerging from this shift is the gut-brain axis."},{"level":3,"_id":"DVSPRQ3DMBHGRKKLMZSIEHYIYU","additional_properties":{},"type":"header","content":"The gut-brain axis is expanding the science of sleep"},{"_id":"WM5RY6R7MVAUZLOCBKQAOQYWHM","additional_properties":{},"type":"text","content":"Sleep has traditionally been viewed as a brain-centered process. While the central nervous system remains the primary regulator of sleep, advances in microbiome research, metabolomics, and systems biology have revealed that sleep regulation extends well beyond the brain itself."},{"_id":"HA4YWOKHNVBF5LJWALRZQZUXDU","additional_properties":{},"type":"text","content":"The gastrointestinal tract communicates continuously with the central nervous system through microbial metabolites, immune signaling, neural pathways, and endocrine communication.<sup>5</sup>"},{"_id":"H5F2QRFGRRFT7OL2K3I5MP53PQ","additional_properties":{},"type":"text","content":"Collectively, these interactions form what is now known as the gut-brain axis. Its significance lies not in the simplistic notion that âthe gut influences the brainâ, but in providing a more integrated understanding of sleep biology."},{"list_type":"unordered","_id":"NYTIZ6GH6FCXNBQRPZFLUXXPBM","type":"list","items":[{"_id":"BPTWBPGI5JGRPLVC3LE2A7GVFE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Intestinal barrier integrity can influence systemic inflammatory signaling"},{"_id":"H6BDFKJSCRG6HMHIYDL5SQVWOY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Low-grade chronic inflammation may affect neurological function"}
2039,{"_id":"J4ENIDVJBFFRBDFMZHXXFVO65I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Metabolic disturbances can interfere with circadian regulation"}]},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg","licensable":false,"alt_text":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","width":1920,"creditIPTC":"Provided by client","_id":"2V53XADCHNHE7F5Q2VFCPBE7QI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","proxyUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg","published":true,"resizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/2V53XADCHNHE7F5Q2VFCPBE7QI.jpg?auth=142ab4d37bb5940823d7f07b86f8911bb1ab8fa8d3e92da1c2783dcf00e24798&width=300","version":0,"originalName":"Figure-2.jpg","mime_type":"image/jpeg","alt_text":"Gut-brain axis diagram showing four crosstalk pathways â immune signalling, neural pathways (GABA), microbial metabolites (Urolithin A), endocrine communication (melatonin)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:43:13Z","last_updated_date":"2026-08-13T10:43:13Z","height":996,"image_type":"photograph"},{"_id":"DWCPINHWRZDGBKMZ7BL6ZPIPEQ","additional_properties":{},"type":"text","content":"Viewed together, these interconnected pathways suggest that sleep quality may depend as much on systemic physiological balance as on central nervous system signaling."},{"_id":"4JNQQHEYNBGUXD2N6EOFHUHC4U","additional_properties":{},"type":"text","content":"This broader perspective is prompting researchers to revisit a number of bioactive compounds that were never originally developed as sleep ingredients."},{"level":3,"_id":"7E5OOVBJ5BFADMALUJHJPG2FTI","additional_properties":{},"type":"header","content":"Why urolithin A is emerging as a promising sleep recovery ingredient"},{"_id":"D7ZTQ3G3FRBTLDR5K35Z2VH6FI","additional_properties":{},"type":"text","content":"Among these emerging compounds, urolithin A (UA) has attracted growing scientific interest."},{"_id":"LL4D5HELCRCBZNR3DDSCUXQFFI","additional_properties":{},"type":"text","content":"Unlike traditional sleep ingredients, urolithin A did not originate from sleep research. Urolithin A is a naturally occurring postbiotic metabolite generated by gut microbiota from dietary ellagitannins."},{"_id":"CWMWM7U7TNGPVBGMZSTF2ETNVE","additional_properties":{},"type":"text","content":"Over the past decade, research on the benefits of urolithin A has expanded from gut microbiota metabolism to broader areas of systemic physiology, including intestinal barrier function, metabolic regulation, cellular homeostasis, and biological resilience."},{"_id":"RJZQZ6XOBNABBJFN4EHQCOM6TU","additional_properties":{},"type":"text","content":"Ironically, that broader scientific foundation may be precisely why it has become interesting for sleep health. Rather than acting as a conventional sleep aid that primarily targets neuronal relaxation, urolithin A is being investigated for its potential to supp
2039ort the physiological systems that contribute to restorative sleep."},{"level":3,"_id":"N5M2LFE6EVEA7HSJRJKFDC72CE","additional_properties":{},"type":"header","content":"A natural fit for gut-brain axis research"},{"_id":"T24QDP7CHNDQTM2DHRTEDUDS7Y","additional_properties":{},"type":"text","content":"Because urolithin A is produced through gut microbial metabolism, it naturally occupies a unique position within gut-brain axis research."},{"_id":"H3XHXGRWAZEILONK7V5EVVEOXE","additional_properties":{},"type":"text","content":"Multiple studies have demonstrated that urolithin A can influence intestinal tight junction proteins, promote protective mucus layer formation, and support mucosal immune defense. Together, these actions contribute to maintaining intestinal barrier integrity â an important upstream factor in gut-brain communication.<sup>6,7 </sup>"},{"_id":"VGJKFNUAKVBNJNCMERCMDIHNRE","additional_properties":{},"type":"text","content":"Instead of directly targeting sleep pathways, urolithin A may help create a healthier physiological environment that supports sleep regulation."},{"level":3,"_id":"FSU6KANVYFEHZITFGDSVDJFJHE","additional_properties":{},"type":"header","content":"Recovery rather than sedation: Supporting restorative sleep"},{"_id":"RBUCMJNLNJGLTOFTFYSXN77EFQ","additional_properties":{},"type":"text","content":"One of the most distinctive aspects of urolithin A is that its scientific story revolves around recovery, not sedation."},{"_id":"DSUD2NMMFREZFN2B5U7IL2G6H4","additional_properties":{},"type":"text","content":"Emerging sleep science increasingly recognizes that restorative sleep and physiological recovery are deeply interconnected."},{"_id":"UTNPWUWNQFCKLLVDZLWLKU443A","additional_properties":{},"type":"text","content":"Interestingly, many of urolithin Aâs previously published studies â although not designed specifically for sleep â share a common theme: improving resilience and recovery."},{"_id":"EQEERQZUSZFRVHGHBNRLJPJF3M","additional_properties":{},"type":"text","content":"For example, a preclinical study from South China Normal University reported that urolithin A reduced neuroinflammation, attenuated glial activation, lowered pro-inflammatory cytokine expression, and improved physical performance following sleep deprivation.<sup>8</sup>"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg","licensable":false,"alt_text":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","width":1920,"creditIPTC":"Provided by client","_id":"4AYDK67AORBZPCBBOQMXIGKRPQ","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","proxyUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg","published":true,"resizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/4AYDK67AORBZPCBBOQMXIGKRPQ.jpg?auth=9e42d15551312399ef13302aa28e4326ac190afbb6403f2e280c8cc944dfd331&width=300","version":0,"originalName":"Figure-3.jpg","mime_type":"image/jpeg","alt_text":"Three-panel preclinical evidence: Urolithin A preserves BMAL1 & PER2 rhythm under inflammation, upregulates SCN expression in mice, increases oscillation amplitude ~4-fold in senescent cells (Nutrients 2024, 2025)","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:44:01Z","last_updated_date":"2026-08-13T10:44:01Z","height":1067,"image_type":"photograph"},{"_id":"S5CHJSSATJF7XOHUD6UW6OPTCQ","additional_properties":{},"type":"text","content":"Although these findings remain preclinical, they provide mechanistic supp
2039ort for exploring urolithin A for sleep as a recovery-oriented ingredient rather than a conventional sleep aid."},{"level":3,"_id":"7KHE3CVC6JGWLISEB4XGPTQQAM","additional_properties":{},"type":"header","content":"A new connection with circadian biology"},{"_id":"WYWW6YZAPVCZXIMGGLY26TXNLA","additional_properties":{},"type":"text","content":"Another emerging area of research involves circadian rhythm regulation. Recent studies suggest that urolithin A may influence the rhythmic expression of core clock genes such as BMAL1 and PER2, helping preserve circadian oscillations under inflammatory conditions.<sup>9</sup>"},{"_id":"Y55ZYIHRCJB3VJHL5RB7QIOO64","additional_properties":{},"type":"text","content":"Animal studies have also reported changes in circadian-related gene expression within the suprachiasmatic nucleus (SCN), the bodyâs master biological clock.<sup>9</sup>"},{"_id":"RYVNHSSUMBFFJOTJGYUJGYT4HQ","additional_properties":{},"type":"text","content":"In senescent cell models, urolithin A has been shown to increase the amplitude of BMAL1 oscillation by approximately four-fold in a dose-dependent manner.<sup>10</sup>"},{"_id":"3A5QJQXJZJB4NKFSPFTFNUIFRY","additional_properties":{},"type":"text","content":"Although these findings require confirmation in human studies, they provide intriguing evidence that urolithin A may influence both peripheral and central circadian regulatory networks."},{"level":3,"_id":"JX7I3ETY5RAEHHFR5JQSCOIRHE","additional_properties":{},"type":"header","content":"From mechanistic research to clinical validation"},{"_id":"AJNSX4GRWNHA3FVSLXLEDXRONI","additional_properties":{},"type":"text","content":"Mechanistic evidence is essential â but it is not enough. Ultimately, the commercial value of any functional ingredient depends on whether mechanistic hypotheses translate into measurable human outcomes."},{"_id":"5NZHAY7JKVD6ZA5BAW5BZ3OWTM","additional_properties":{},"type":"text","content":"Recognizing this, StanYouth® Urolithin A has initiated a randomized, quadruple-blind, placebo-controlled clinical trial (NCT06990256) involving adults with impaired sleep quality."},{"_id":"4NUSYX5N2BHF3FM3PZ44VXE3JE","additional_properties":{},"type":"text","content":"The 12-week study compares urolithin A alone, fisetin alone, their combination, and placebo. Importantly, the trial extends beyond subjective sleep questionnaires. Researchers are incorporating polysomnography (PSG), wearable actigraphy, aging biomarkers, and gut microbiome analysis to evaluate subjective sleep experience, objective sleep architecture, and underlying biological mechanisms simultaneously."},{"_id":"OHFTIRHU5VHBXEH4POYRKWBKWI","additional_properties":{},"type":"text","content":"This multidimensional design reflects a broader shift occurring across the dietary supplement industry: the future of sleep innovation will increasingly depend on robust clinical evidence rather than mechanistic speculation alone."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/THRB3EWH4JHUNC34RG44Q44K7Q.jpg","licensable":false,"alt_text":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","width":1920,"creditIPTC":"Provided by client","_id":"THRB3EWH4JHUNC34RG44Q44K7Q","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","proxyUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/THRB3EWH4JHUNC34RG44Q44K7Q.jpg","published":true,"resizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/THRB3EWH4JHUNC34RG44Q44K7Q.jpg?auth=d548f517169e2592967981044ace82a08b4c0e8184f48005cb7361421fbab202&width=300","version":0,"originalName":"Figure-4.jpg","mime_type":"image/jpeg","alt_text":"StanYouth Urolithin A clinical trial (NCT06990256): 12-week randomized, quadruple-blind, placebo-controlled study in 80 adults with PSQI >5, evaluating UA, Fisetin, combination and placebo via PSG, actigraphy, aging biomarkers, gut microbiome","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-13T10:44:42Z","last_updated_date":"2026-08-13T10:44:42Z","height":1138,"image_type":"photograph"},{"level":3,"_id":"EL3CS5V7J5BBBILLEPTMUKNGQI","additional_properties":{},"type":"header","content":"The future of sleep supplements may be about recovery"},{"_id":"IO4YE3VRVZAMPKGYAYED3WCO7U","additional_properties":{},"type":"text","content":"Melatonin is unlikely to disappear from the sleep category. Nor should it. It remains one of the most effective ingredients for supporting circadian rhythm and sleep onset."},{"_id":"UZ5BONS7NBCNNKGRPGWY736Y64","additional_properties":{},"type":"text","content":"However, consumer expectations are changing. The next generation of sleep supplements is unlikely to compete solely on how quickly consumers fall asleep. Instead, success may increasingly depend on helping consumers wake up restored, resilient, and physiologically recovered. That is the promise of a true sleep recovery supplement."},{"_id":"JVJOCFX7WFEJPA3KNP4ARXHGMM","additional_properties":{},"type":"text","content":"As scientific understanding expands from neurotransmitters to the gut-brain axis, circadian biology, and systemic recovery, ingredients such as StanYouth Urolithin A represent an entirely new direction for sleep health innovation."},{"_id":"JSVFJXE3HFCQTODPGOJNTXNVX4","additional_properties":{},"type":"text","content":"The future of the category may no longer be defined by sleep aid. It may instead be defined by<b> </b>Sleep Recovery."},{"_id":"I5YICOG5OVDYNK7L6EV5NCG3NQ","additional_properties":{},"type":"text","content":"<a href=\"https://www.bonerge.com/branded-ingredients/stanyouth-urolithina\" target=\"_blank\" rel=\"\" title=\"https://www.bonerge.com/branded-ingredients/befisetin-fisetin\"><b>Find out about StanYouth here.</b></a>"},{"_id":"BDTORJZXQNEDZKYS2RXOMLHRLM","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"WKGWBGAD3NA5POYPGUBWV6QZBE","type":"list","items":[{"_id":"6MWFAXUXJBBPJJAPCLWRBJ5M5Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"PR Newswire. <a href=\"https://www.prnewswire.com/news-releases/natrol-the-nations-top-melatonin-brand-introduces-soothing-night-its-first-sleep-aid-supplement-without-melatonin-301933546.html\">Natrol®, the Nationâs Top Melatonin Brand, Introduces Soothing Night®, Its First Sleep Aid Supplement Without Melatonin.</a>"},{"_id":"7NYRW6YCNVB5FD2ZL3OIKGAXDY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Chen, RJ.; et al. <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK526124/\">GABA Receptor.</a> StatPearls Publishing. 2026."},{"_id":"YFOLIAMYZNGK7HQ3VZZUT4G4E4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kothari, M.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC11444808/\">A comprehensive review on understanding magnesium disorders: Pathophysiology, clinical manifestations, and management strategies.</a> Cureus. 2024 Sep 1;16(9):e68385. "},{"_id":"XYUWZWFBZFFBNAI2KAIQSK2XWI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Nobre AC.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/18296328/\">L-theanine, a natural constituent in tea, and its effect on mental state.</a> Asia Pac J Clin Nutr. 2008;17(Suppl 1):167-168."},{"_id":"HPZCBGIT4BFQBNPZYVEK7PIJOA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Chen, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/40952592/\">Microbiotaâgutâbrain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets.</a> Mol Biomed. 2025 Sep 15;6:64."},{"_id":"SYV33PZ7LVAGZKD6TTERIS6XDE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Ghosh, S.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/42336837/\">Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.</a> Nat Commun. 2026 Jun 23;17(1):5411. "},{"_id":"HRPA4JOERBC2HJ5WRVZN3J2KPE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Yasuda, T.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38977770/\">Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis.</a> Sci Rep. 2024 Jul 8;14(1):15706. "},{"_id":"WC63GSWVMJEBVOPVQD6MZYQXNA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Zhu, H.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38977770/\">Urolithin A Ameliorates Athletic Ability and Intestinal Microbiota in Sleep Deprivation from the Perspective of the Gut-Muscle Axis.</a> Mol Nutr Food Res. 2024 Apr;68(7):e2300599. "}
2039,{"_id":"3U2KCDSXZNEXRL66YM646DRREI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Du, Y.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39064706/\">Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation.</a> Nutrients 2024, 16, 2263."},{"_id":"3NQP5AUVKZDPPOI6TYLQRVORUE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kuatov, R.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39796454/\">Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells.</a> Nutrients 2025, 17, 20."}]}],"subheadlines":{"basic":"As sleep supplements shift from sleep aid to sleep recovery, urolithin A is emerging as a gut-brain axis ingredient for restorative, non-melatonin sleep."},"description":{"basic":"As sleep supplements shift from sleep aid to sleep recovery, urolithin A is emerging as a gut-brain axis ingredient for restorative, non-melatonin sleep."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Promotional features","description":"","_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"website":"nutraingredients-v2","navigation":{"nav_title":"Promotional features","root_section":"false","type":"news"},"_admin":{"alias_ids":["/News/Promotional-features"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Promotional features","_id":"/News/Promotional-features","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Regions/Europe","parent":{"default":"/Regions"},"_website":"nutraingredients-v2","parent_id":"/Regions","name":"Europe","description":"","_id":"/Regions/Europe","additional_properties":{"original":{"parent":{"default":"/Regions","main-navigation":"/Regions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Europe","root_section":"false","type":"region"},"_admin":{"alias_ids":["/Regions/Europe"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Europe","_id":"/Regions/Europe","regions_tabs":{"latam":"false","emea":"false","apac":"false","noam":"false"},"order":{"default":35,"main-navigation":35}}},"_website_section_id":"nutraingredients-v2./Regions/Europe","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"navigation-links":"/","default":"/","main-navigation":"/"},"website":"nutraingredients-v2","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"navigation":{"nav_title":"Health conditions","root_section":"true","type":"news"},"_admin":{"alias_ids":["/Health-conditions"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Health conditions","_id":"/Health-conditions","ancestors":{"navigation-links":["/"],"main-navigation":["/"]},"order":{"navigation-links":1004,"default":23,"main-navigation":1004}}},"_website_section_id":"nutraingredients-v2./Health-conditions","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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A drug class capable of driving double-digit percentage weight loss can substantially reduce food intake, changing the nutritional challenges patients face during treatment and potentially beyond it."},{"_id":"EKOA5OOQCZAT7B3LKM6SJW4SRE","additional_properties":{},"type":"text","content":"That is because the same appetite suppression driving the headline results of GLP-1s is creating a quieter issue underneath the topline weight-loss figures. A significant share of that weight loss can come from lean mass rather than just fat, while substantially reduced food intake raises questions about whether some patients may struggle to meet their needs for protein and other nutrients."},{"_id":"JO6UVNG65FESFIU7K6O6RSM75Y","additional_properties":{},"type":"text","content":"As clinical and formulation attention shifts from simply how much weight patients lose to what kind, the question of how to support muscle health throughout GLP-1 therapy is becoming one of the more pressing conversations in nutrition science. Alongside established strategies such as adequate protein intake and resistance exercise, omega-3 fatty acids are being investigated for their potential to support muscle health and help preserve lean mass during weight loss."},{"level":3,"_id":"CJL5YHNCSBBTZEU6Y5AVYS52NI","additional_properties":{},"type":"header","content":"The GLP-1 nutritional squeeze"},{"_id":"AAXZRWE4PNCFDNWBWKTGLVXYJ4","additional_properties":{},"type":"text","content":"GLP-1s work by suppressing appetite, and that mechanism is central to their effectiveness. Patients on these medications have been shown to consume 16 to 39% fewer calories than before starting treatment.<sup>3</sup> Gastrointestinal side effects, including nausea, early satiety and slower gastric emptying, add a further layer of difficulty around eating enough to meet nutritional requirements, or eating a varied enough diet."},{"_id":"UK3EOK7SYFB6LO7YHK3RAUXNXY","additional_properties":{},"type":"text","content":"Reduced intake affects total nutrition, but muscle mass is where the impact has drawn the most attention. Research suggests that around 20% to 50% of weight lost during GLP-1 treatment may comprise lean body mass.<sup>4</sup> This has prompted dietitians, formulators and pharmaceutical companies alike to look more closely at what patients need nutritionally to protect muscle while losing weight quickly."},{"_id":"H33AK447ORFCRATIIAK7O2BIPI","additional_properties":{},"type":"text","content":"Protein has understandably become the focal point of that response. However, with appetite suppressed and food volume down, patients may also be at risk of inadequate intake of protein, vitamins, minerals and other essential nutrients, even when weight loss itself is tracking as expected.<sup>4</sup> This is leading to deeper questions being asked on what âcompleteâ nutrition should look like when individuals are taking GLP-1s."},{"level":3,"_id":"UH2PCOM2KFCATHQJM2T3APWY3E","additional_properties":{},"type":"header","content":"Protein and exercise remain foundational"},{"_id":"UZUSOFTXHJAPTAU2LA44ZN7UBQ","additional_properties":{},"type":"text","content":"None of this changes the fundamentals of muscle preservation during weight loss. Higher protein intake, with targets commonly proposed around 1.2g to 2g per kg per day during active weight reduction, combined with resistance training, is among the best-supported strategies for protecting lean mass during any period of energy restriction.<sup>5</sup> "},{"_id":"ZPKSEUKX5BET3JGAP2ZBWJZDBQ","additional_properties":{},"type":"text","content":"Clinical guidance for GLP-1 patients has largely reinforced that message, with dietitians and obesity medicine specialists prioritising protein intake and strength training as first-line advice."},{"_id":"MNO6RFM7WNHPVCCG2GHVUIEHPI","additional_properties":{},"type":"text","content":"The difficulty is putting that guidance into practice. Patients dealing with suppressed appetite and gastrointestinal side effects can struggle to reach recommended protein targets through food alone, and reduced intake elsewhere in the diet compounds the problem. "},{"_id":"K5HMDDA24RAXFNKZQE5XCZSF7M","additional_properties":{},"type":"text","content":"That gap between recommendation and reality is what is driving interest in additional nutritional support, including ingredients like omega-3 fatty acids, which can work alongside protein and exercise rather than replace them."},{"level":3,"_id":"BJZXB4XVBZEL3GG5QCSBYQ5J6M","additional_properties":{},"type":"header","content":"Where omega-3 fits in"},{"_id":"R42XLSMKRRCJRG3RL24M3M4JJQ","additional_properties":{},"type":"text","content":"The interest in omega-3 fatty acids and muscle health predates the GLP-1 boom by well over a decade. The two long-chain omega-3s most relevant to this discu
2039ssion are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), both found predominantly in oily fish and fish oil. The theory is that these fatty acids do not just sit passively in the diet. Once consumed, they can be incorporated into skeletal-muscle membranes, where research suggests they may influence signalling pathways involved in muscle protein synthesis and breakdown."},{"_id":"KTPMDWXJ5FAPZEAQIKR72ZOSTY","additional_properties":{},"type":"text","content":"A review of the underlying biology has linked DHA and EPA incorporation into skeletal-muscle membranes with changes in anabolic signalling and muscle protein turnover.<sup>6</sup> "},{"_id":"F7AVNNWTY5CN5ERXCXCWRXGZ5Q","additional_properties":{},"type":"text","content":"On the clinical side, a randomized controlled trial in older adults found that omega-3 supplementation enhanced the muscle protein synthesis response to amino acids and insulin, helping the body make more effective use of the protein it does receive.<sup>7 </sup>While this study was not conducted in people taking GLP-1 medications, it provides clinical evidence that omega-3 may influence muscle protein synthesis in older adults."}
2039,{"_id":"6LDSDWGQHBCS7LR5VHSINSPHH4","additional_properties":{},"type":"text","content":"A 2020 meta-analysis of 10 randomized controlled trials in 552 older adults found that omega-3 supplementation was associated with a small but statistically significant gain in muscle mass compared with control groups, with a larger effect seen among participants taking more than 2g per day.<sup>8</sup> The analysis also reported improvements in some measures of physical performance."},{"_id":"4USMHVE5IBB3NHNEAAE5JG6FV4","additional_properties":{},"type":"text","content":"A 2023 systematic review of 21 intervention studies in adults examined omega-3 in a range of formats, including formulations combining omega-3 with protein, leucine and vitamin D, as well as products incorporating omega-3 into enteral nutrition. The review found that a substantial number of individual studies suggested potential benefits for maintaining or gaining muscle mass.<sup>9</sup>"},{"_id":"35WKZPI4ZNAXXMHLVEXVRK2R5Q","additional_properties":{},"type":"text","content":"The findings also point to omega-3 being studied as part of broader nutritional strategies, rather than solely as a standalone supplement. This is a relevant consideration when thinking about the nutritional needs of people taking GLP-1s."},{"level":3,"_id":"GCHIYHPCVZAQNGEX4YWKTAKMSE","additional_properties":{},"type":"header","content":"The formulation challenge"},{"_id":"SVYPOQLH35G4RNRKZDD2CKEXDE","additional_properties":{},"type":"text","content":"Though research into omega-3âs role in muscle health continues to grow, getting the supplement into a product that patients will actually take consistently is its own challenge. Fish oilâs sensory drawbacks are well documented: oxidation, a fishy aftertaste and lingering odor have long limited its use in everyday formats like powders, shakes and stick packs. "},{"_id":"RLGNQZUPBZBRNAAMVB4F43MXWA","additional_properties":{},"type":"text","content":"A capsule regimen is one more thing to remember on top of medication schedules, appetite changes and gastrointestinal (GI) symptoms, and for many patients that is a barrier to consistent use."},{"_id":"2Z4Z4LV3HVBJVN7ITGINW4WU4Y","additional_properties":{},"type":"text","content":"This is the problem microencapsulation is designed to solve. The process coats the omega-3 oil in a protective layer, guarding against oxidation and masking taste and odor, which allows DHA and EPA to be built directly into palatable, nutrient-dense formats rather than confined to capsules. This innovation simplifies omega-3 fortification in nutrient dense food and beverage applications. "},{"_id":"PZ3XWLAVYFEOHG5PMQYH6DDIN4","additional_properties":{},"type":"text","content":"For manufacturers, the opportunity is not to position omega-3 as a replacement for protein or resistance exercise, but as a complementary nutritional strategy within a broader approach to muscle health during GLP-1-supported weight management. As research continues to explore how DHA and EPA may influence muscle protein metabolism, omega-3 is emerging as an area of interest alongside the more established foundations of adequate protein intake and resistance exercise."},{"_id":"HEZACAUOHZDFJEIEFWLOU77ZNY","additional_properties":{},"type":"text","content":"The challenge is translating that science into products that consumers can realistically incorporate into their daily routines. Microencapsulation can help address some of the sensory and stability challenges associated with omega-3, opening up opportunities to deliver DHA and EPA in convenient formats. "},{"_id":"DK5KZSOIRVGMHMHZ65ZPZXOXFU","additional_properties":{},"type":"text","content":"For formulators responding to the nutritional demands of the growing GLP-1 market, combining established nutritional strategies with emerging ingredients and practical delivery formats could become an increasingly important part of the conversation."},{"_id":"XWEOCYMURRDIPHW3PCQ55DPRZY","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"MF477KNFMNBC5ON5MBF5MMNQDE","type":"list","items":[{"_id":"QUMQM6JYERG6JEWP3GLWPYB4SU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"KFF. <a href=\"https://www.kff.org/public-opinion/poll-1-in-8-adults-say-they-are-currently-taking-a-glp-1-drug-for-weight-loss-diabetes-or-another-condition-even-as-half-say-the-drugs-are-difficult-to-afford/\">Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford.</a>"},{"_id":"X6KHJI4WEFGEXHRE4UNBIABG3I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"ING. <a href=\"https://think.ing.com/articles/transformative-or-overhyped-the-impact-of-weight-loss-drugs-on-european-food-demand1/\">Transformative or overhyped? The impact of weight-loss drugs on European food demand.</a> "},{"_id":"YNHWJCUOJBBQNHMAQYVPRAAHFY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Christensen, S.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39175746/\">Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: a narrative review and discussion of research needs.</a> Obes Pillars. 2024;11:100121. "},{"_id":"HJQUZWRAMZGIZDBK6FRRHPPIBI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Johnson, BVB.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/41368199/\">Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: a narrative review.</a> Obes Pillars. 2025;16:100209."},{"_id":"TOAQ7D3ATBATDGIJCXVDGR7P2E","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Mozaffarian, D.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/40445127/\">
2039Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society.</a> <i>Am J Clin Nutr</i>. 2025;122(1):344-367."},{"_id":"FEO3IZFQ5BC6DN5JKF7MAZP3D4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"McGlory, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/31555658/\">The influence of omega-3 fatty acids on skeletal muscle protein turnover in health, disuse, and disease.</a> Front Nutr. 2019;6:144."},{"_id":"XWS2MEM5PVCNPC5PT5YHKTF57I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Smith, GI.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/21159787/\">Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial.</a> <i>Am J Clin Nutr</i>. 2011;93(2):402-412. "},{"_id":"RHOQLX3EFFANZC24GE3CX3SRLM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Huang, YH.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/33291698/\">Effects of omega-3 fatty acids on muscle mass, muscle strength and muscle performance among the elderly: a meta-analysis.</a> Nutrients. 2020;12(12):3739."},{"_id":"CFKFXYAKORGWXE7DIEOW4WTDVA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Moon, GK.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/37969938/\">Effects of omega-3 fatty acid supplementation on skeletal muscle mass and strength in adults: a systematic review.</a> Clin Nutr Res. 2023;12(4):304-319."}]}],"subheadlines":{"basic":"As GLP-1 use grows worldwide, concern over lost lean mass alongside weight loss is rising, but research points to omega-3âs potential role in supporting lean mass."},"description":{"basic":"As GLP-1 use grows worldwide, concern over lost lean mass alongside weight loss is rising, but research points to omega-3âs potential role in supporting lean mass."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Weight-management","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Weight management","description":"","_id":"/Health-conditions/Weight-management","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Weight management","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Weight-management"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Weight management","_id":"/Health-conditions/Weight-management","regions_tabs":{"latam":"true","emea":"true","apac":"true","noam":"true"},"order":{"default":27,"main-navigation":27}}},"_website_section_id":"nutraingredients-v2./Health-conditions/Weight-management","type":"section","version":"0.6.0"},{"path":"/Health-conditions","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"Health conditions","description":"","_id":"/Health-conditions","additional_properties":{"original":{"parent":{"
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2039hwagandha ingredients for both safety and efficacy. "},{"_id":"SPLCM45SGNEOJMZJBIE4BQW3IE","additional_properties":{},"type":"text","content":"âWe saw modern science literally supporting traditional use here,â Low Dog said when discussing research based on KSM-66 root extract, investigating stress and cortisol management. "},{"_id":"DT7ZSCJ5VNEWJBHURIVTKMHYWM","additional_properties":{},"type":"text","content":"This includes a 12-month safety study, a 12-week high-dose study at 2,000 mg/day<sup>,</sup> and a large global study involving more than 1,000 participants.<sup> 2-4</sup> Together, these studies demonstrate that KSM-66 has been evaluated across longer durations, higher doses and a large participant population, making it one of the most comprehensively studied ashwagandha root extracts from a safety perspective."},{"_id":"7ODB4YEFXJGVLIWW7WRVVL43VQ","additional_properties":{},"type":"text","content":"âWhat is particularly important is that the research has examined not only efficacy, but also safety across longer durations, higher doses and large participant populations,â said Low Dog. âThat breadth of evidence gives formulators and consumers a more complete understanding of the specific extract.â"},{"_id":"YA4PRU6D7JHEJPQDDYDBX4I6VY","additional_properties":{},"type":"text","content":"Low Dog examined evidence across multiple areas, including stress management, sleep quality, cognitive function, sports performance, healthy ageing, menâs health and womenâs wellbeing. She also emphasised the importance of understanding exactly which extract is used in clinical research."},{"_id":"BAHCOTQBDBBAVJABTL6D5VINQY","additional_properties":{},"type":"text","content":"âNot all root extracts or ashwagandha extracts are equivalent,â said Low Dog. âWe want to know if weâre looking at the clinical research, what was the clinical research done on? Is the extract reproducible and is the research reproducible?â KSM-66 is a root-only extract with 5% total withanolides, produced by a green chemistry extraction process. It also has a fully integrated vertical supply chain. "},{"_id":"ZCMZXEABRZH5HIAOLL4PRNA46U","additional_properties":{},"type":"text","content":"Discussing the relevance of adaptogens for consumers in todayâs increasingly busy and demanding world, Low Dog described how certain botanicals may help support the bodyâs ability to cope with everyday stressors."},{"_id":"UQN4ZYAHXJFRXF2GD3LRQ4C6QE","additional_properties":{},"type":"text","content":"âThere are plants that help the body increase its capacity, widen the margin for resilience, and over time allow people to manage their stress more effectively⦠Ashwagandha is the most calming of the adaptogens,â she continued."},{"level":3,"_id":"SEBIXIUQSRBV5P5H2LBJUZPQOI","additional_properties":{},"type":"header","content":"Consumer demand for stress and sleep support"},{"_id":"QCSEHQMALJANFPIWOMOCFA67K4","additional_properties":{},"type":"text","content":"As consumer interest in ashwagandha increases, the opportunity for evidence-backed ingredients that have been researched in relation to benefits for improving sleep and stress grows. "},{"_id":"7NMQIBJQWZGF5I5PDGXDIV6PGI","additional_properties":{},"type":"text","content":"Jordan Rubin, natural health expert, formulator and founder of Garden of Life, Ancient Nutrition and Beyond Organic, believes ashwagandha is a vital ingredient in the formulatorâs toolbox. He explores the category, and looks at KSM-66âs performance specifically, in a SPINS data in the video below."},{"subtype":"jw_player","_id":"24VMYKGZRVEMBKML5HLX5W74AU","embed":{"id":"kGntZi0D","config":{"image":"https://cdn.jwplayer.com/v2/media/kGntZi0D/poster.jpg?width=720","id":"kGntZi0D","title":"SPINS%20category%20presentation"},"url":"https://cdn.jwplayer.com/players"},"type":"custom_embed"},{"_id":"FAXRJA3JAFDJLO6UXFUSZSIVF4","additional_properties":{},"type":"text","content":"Ewa Hudson, Lumina Intelligence, presented new data that highlighted sleep as the leading health concern across genders and age groups with stress ranking second among health concerns. And according to the research, consumers experiencing higher levels of stress are increasingly turning to adaptogens, including ashwagandha, as part of their wellbeing routines.<sup>5</sup>"},{"_id":"CZAVD4AS6NHJJCREU3QNGQPIRQ","additional_properties":{},"type":"text","content":"âThe older we become, the more we look at our diet and supplementation, and it actually over indexes here as weâre hitting 30,â Ewa explained. âBy recognising how wellness routines change with age and showing up as a consistent, supportive partner alongside these daily activities, brands can actually become truly trusted partners.â"},{"_id":"JVAYT7GSYNE5NGUUQ6TJVFLE54","additional_properties":{},"type":"text","content":"This growing interest in adaptogens is something Jordan Rubin has observed during more than 25 years in the supplement industry as a formulator. Drawing on SPINS market data, Rubin highlighted the growth of products containing KSM-66 across both in bricks-and-mortar retail stores and ecommerce channels."},{"_id":"KJVTQEQLUVEJTBZOYKWSALPYCI","additional_properties":{},"type":"text","content":"âEight out of the 10 fastest growing brands of ashwagandha [are] utilising KSM-66 as their premier ingredient⦠on Amazon out of the best-selling ashwagandha products, the only branded ingredient that is used is KSM-66 Ashwagandha,â said Rubin. âAnd most importantly, [itâs] backed by dozens of randomised controlled trials and truly represents an ingredient for this generation.â"},{"level":3,"_id":"BXVDFLN4NJCHXPVI46PRHVX4UA","additional_properties":{},"type":"header","content":"Regulatory considerations"},{"_id":"SRY5GH2KYFFI3FT55HS2J545PQ","additional_properties":{},"type":"text","content":"Alongside the growing consumer interest in ashwagandha, regulatory developments are becoming increasingly important for the sector."},{"_id":"JRN7JSRAS5D5FI5VLJ7I7RY6WA","additional_properties":{},"type":"text","content":"Mari Lyyra, regulatory affairs manager at Medfiles, a consultancy that works with companies across the food and supplement sectors to navigate regulatory frameworks, provided an overview of the current European landscape, explaining that while ashwagandha is not considered a novel food ingredient in the EU, questions continue to be raised around safety assessments, extract characterisation and differences between plant parts. "},{"_id":"SUSDMQA2EJEERE2626GRE25IY4","additional_properties":{},"type":"text","content":"Lyyra set out the different phytochemical profiles of different plant parts. âItâs clear that root and other plant parts need to be separated and more characterisation, and safety data on different ashwagandha parts and products and extracts is needed,â she said. "},{"_id":"GT6LC2QH5FB57JTAYK64BVVZR4","additional_properties":{},"type":"text","content":"Lyyra also discussed ongoing regulatory reviews taking place across Europe and n
2039oted that any future EU-wide assessment process could take considerable time to complete. "},{"_id":"32XGT6E3UFE5VBYHXIBMPF73LA","additional_properties":{},"type":"text","content":"For manufacturers and formulators, this underlines the importance of ingredient labelling, supply-chain transparency and robust safety data as the category continues to mature. There have been reports of ashwagandha adulteration globally, highlighting the importance of robust quality controls, accurate labelling and supply-chain transparency. KSM-66 positions its vertically integrated supply chain as a means of supporting traceability and consistency.<sup> 6</sup>"},{"level":3,"_id":"MW45OOFB7ZBR7AA53VY2PBPMTI","additional_properties":{},"type":"header","content":"Formulatorâs viewpoint "},{"_id":"VOILXAAEBFBMNH2K4XGI7DFLSE","additional_properties":{},"type":"text","content":"As regulatory scrutiny increases, transparency around sourcing, standardisation and ingredient selection is becoming increasingly important for brands operating in the category."},{"_id":"KLE7RWTWTNBVNKVC7AP2LO2YBA","additional_properties":{},"type":"text","content":"In this Spotlight On, Tom Johnsson explored the ingredient from a formulatorâs standpoint. As founder of the Medicine Garden brand, he talked about the benefits of using KSM-66 Ashwagandha: "},{"_id":"IUMN2OE6L5AM5HR2ALBOJ2E7BY","additional_properties":{},"type":"text","content":"âWe have been working actually 40 years in the health industry and weâve always been focusing on adaptogens⦠But we have never, ever worked with a supplement that gives so much positive feedback from the consumer,â said Johnsson."},{"_id":"MVXUKXBYGFCNZBYAGUD26FNGAU","additional_properties":{},"type":"text","content":"âThe main reason why we [use] it is of course what it can do for the consumer, but itâs also that the very even grade of extraction makes it very easy to flow in the capsule. There are no additives into the capsules. So we can use clean label, and that is also very important for us.â"},{"_id":"MMYU2ELCONCARDEWHRHHP5HOAM","additional_properties":{},"type":"text","content":"<b>To discover more about KSM-66âs scientific studies and why transparency is so important in the face of category regulation, watch </b><a href=\"https://onlinexperiences.com/scripts/Server.nxp?LASCmd=AI:4;F:QS!10100&ShowUUID=22780238-8307-4824-A01E-C7DD245C235B&GroupID=Onyx&AffiliateData=Web-Webbox-ASHWASPOTKSMJUNE26_NI&Referrer=https%3A%2F%2Fwww.nutraingredients.com%2F\" target=\"_blank\" rel=\"\"><b>Ashwagandha: Science, regulation and transparency</b></a><b> on demand now.</b>"},{"_id":"SWUQJZYET5DPFNTU4AFFDNNBDE","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"QSWQX6NK4RDXLCT5WFXR2KQD34","type":"list","items":[{"_id":"GBFLBRENTRBTHBPNHEJ7CWXAH4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Grand View Research. <a href=\"1.%09https:/www.grandviewresearch.com/industry-analysis/ashwagandha-supplements-market-report\">Ashwagandha Supplements Market (2026 - 2033)</a>"},{"_id":"3POTIWZWZFGXBK622ARFHOCZQE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Salve J.: et al. <a href=\"https://onlinelibrary.wiley.com/doi/10.1002/ptr.70096\">Safety of 12-Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study.</a> Phytotherapy Research. 2025. "},{"_id":"K3DQHSPNGVCJBO6SM45OFVPSJA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Movva N.: et al. <a href=\"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1823678/full\">Safety and tolerability of Ashwagandha (Withania somnifera) root extract in healthy adults: a prospective, non-comparative study.</a> Frontiers in Nutrition. 2026;13:1823678. "},{"_id":"FYPRQK7J45CO5BHJGVSJQ4OCV4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pakhale K.: et al. <a href=\"https://onlinelibrary.wiley.com/doi/10.1002/ptr.70315\">Safety of 8-Week Administration With Ashwagandha (Withania somnifera) Root Extract in Adults With Stress and Anxiety: Findings From a Prospective, Randomized, Multi-Center, Double-Blinded, Placebo-Controlled Study.</a> Phytotherapy Research. 2026. "},{"_id":"LFKRMBNST5HNJH2JWTE6ZQHO5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Lumina Intelligence. <a href=\"https://www.nutraingredients.com/Article/2026/04/08/lumina-reveals-how-womens-health-priorities-and-self-care-is-shifting/\" target=\"_blank\" rel=\"\" title=\"https://www.nutraingredients.com/Article/2026/04/08/lumina-reveals-how-womens-health-priorities-and-self-care-is-shifting/\">Global Nutrition Consumer Research</a>. November 2024 (n= 6,000)"},{"_id":"YNZQ4QKPVNHDJES7TP3YUADTIQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"American Botanical Council. <a href=\"https://www.herbalgram.org/news/press-releases/2025/bapp-new-ashwagandha-root-extract-adulteration/\" target=\"_blank\" rel=\"\" title=\"https://www.herbalgram.org/news/press-releases/2025/bapp-new-ashwagandha-root-extract-adulteration/\">
2039BAPP Publishes Laboratory Guidance Document on Ashwagandha Root and Root Extract Adulteration</a>"}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha grows, how can science-backed ingredients and greater transparency help build trust among consumers, formulators and regulators? "},"description":{"basic":"As consumer demand for ashwagandha grows, how can science-backed ingredients and greater transparency help build trust among consumers, formulators and regulators? "},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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2039se considerations are becoming increasingly important for maintaining consumer confidence and regulatory trust."},{"level":3,"_id":"4YANPE6X3BCTVPZY4IWBHBB6AQ","additional_properties":{},"type":"header","content":"Regulators raise concerns over safety and consistency"},{"_id":"DDOVH4CUIVDJNNYC7VH3GQSHIM","additional_properties":{},"type":"text","content":"In Europe, Denmark moved to ban ashwagandha in 2023, citing difficulties in establishing safe intake levels. Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all comes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve c
2039ommunication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
2039ss the key issues shaping the future of the category."},{"_id":"WK4Y3HVPWND4LNWCNBVIALLFNU","additional_properties":{},"type":"text","content":"<a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\"><b>Watch: âAshwagandha: Understanding the Science, Scrutiny and Standardsâ On Demand now to learn about the latest developments in the ashwagandha category.</b></a><b> </b>"}],"subheadlines":{"basic":"A deep dive into the science behind ashwagandha, the regulatory considerations and what the future holds for the category. 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The next opportunity is connecting them.</b>"},{"_id":"4AAQ7DJVLFARDLVVDYL5KKFAF4","additional_properties":{},"type":"text","content":"Borrowing a concept from technology, a âfull stackâ brings together the different layers required to create a complete solution. The parallel to nutrition and wellness is compelling: while the industry may operate in individual layers, consumers experience the outcome as a whole."},{"_id":"TNRNUTHIQBA2FGAPBRYD7ZJI2M","additional_properties":{},"type":"text","content":"Consumers do not think about ingredient suppliers, formulation constraints, dosage-form technologies, manufacturing capabilities, or regulatory pathways. They think about outcomes<i>:</i> they want more energy; to stay strong; to sleep better; to perform better; and feel like the best version of themselves. 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That is the idea behind Full-Stack Wellness: an approach that starts with the consumer need and connects the layers required to address it â insight, science, ingredients, formulation, delivery, manufacturing, and, ultimately, the consumer experience."},{"_id":"E4CYL6DVSNBMZKNSOKYWTU7A7E","additional_properties":{},"type":"text","content":"TSI sees four opportunities for companies across the wellness ecosystem to put full-stack thinking into practice: design around the consumer rather than the category; design delivery alongside the science; solve the whole consumer problem; and connect the physical and digital wellness experience."},{"level":3,"_id":"DPA5J22Z4FCOBIF4UWM6CO2PUA","additional_properties":{},"type":"header","content":"Design around the consumer, not the category"},{"_id":"TV7MN5C6ZNDQ7K3SZEBPNDE5ME","additional_properties":{},"type":"text","content":"One of the clearest shifts in wellness is toward greater personalization. Consumers increasingly expect products and routines to reflect their goals, lifestyles, and life stages rather than offering one answer for everyone."},{"_id":"OQAJHFH4IZBTTM3NCCN4T2M5DQ","additional_properties":{},"type":"text","content":"Innova Market Insights describes a continuum ranging from bespoke programs informed by biomarkers and DNA to more scalable personalization using questionnaires and âlifestyle stacksâ aligned with specific wellness objectives. Innova also points to the rise of hybrid and bundled products designed to address multiple needs while making wellness choices easier for consumers.¹"},{"_id":"T5GMKLWLOBA3PIXM6PBAWGJTPM","additional_properties":{},"type":"text","content":"But personalization is about more than tailoring a recommendation. It changes where innovation begins. Instead of asking, âwhat ingredient should we sell?â or âwhat product should we make?â, the better questions are: Who is this consumer? What are they trying to accomplish? And what combination of science, nutrition, format, and experience can best support that goal?"}
2039,{"_id":"WNDUPVMPM5HXRNCG6NRG2AGBKQ","additional_properties":{},"type":"text","content":"Starting there makes traditional category boundaries less important. Consumers do not experience wellness according to the organizational structure of our industry. Their needs overlap, interact, and change over time."},{"_id":"UMOO6WDMFVDAXAQBPWA2A6MF74","additional_properties":{},"type":"text","content":"Longevity is a good example. A consumer may not identify as an athlete or even think of themselves as a âhealthy agingâ consumer. They may simply want to stay strong, think clearly, recover well, and continue doing the things they enjoy. Addressing that outcome may require thinking across muscle health, cognition, mobility, metabolic health, sleep, and nutrition rather than choosing a single category."},{"_id":"HCD7UEVFH5DSTFASDYZSSYUGEM","additional_properties":{},"type":"text","content":"TSI sees an opportunity to develop around health outcomes rather than individual ingredients. That can mean synergistic ingredient systems, science-backed combinations, and a more holistic view of health categories."},{"_id":"ODJ2WXCPSJC2FHD2X64GBUBED4","additional_properties":{},"type":"text","content":"Full-Stack Wellness does not mean putting every possible benefit into one product. It means understanding the complete consumer need and determining which combination of science, ingredients, formats, and experiences can address it most effectively. The need comes before the SKU, and the outcome comes before the category."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg","licensable":false,"alt_text":"Supplement delivery formats","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Supplement delivery formats","width":831,"creditIPTC":"Provided by client","_id":"HHH7Q3CP2NBHXLBSMII57VG2F4","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","proxyUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg","published":true,"resizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/HHH7Q3CP2NBHXLBSMII57VG2F4.jpg?auth=82c3c9a6d95d80fed275a94af64bd9b2e5cefefd412514be29ab4030d84b7748&width=300","version":0,"originalName":"NI_TSI_Multi_Delivery_Formats-1.jpg","mime_type":"image/jpeg","alt_text":"Supplement delivery formats","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:14:31Z","last_updated_date":"2026-09-11T10:14:31Z","height":303,"image_type":"photograph"},{"level":3,"_id":"NPMDYR5KMNEHTLRY4Z2WCGIHSA","additional_properties":{},"type":"header","content":"Design the delivery alongside the science"},{"_id":"CB2EU6VNBFAQRD77JY6YH2VHDY","additional_properties":{},"type":"text","content":"Selecting the right ingredients is only part of creating a successful wellness solution. Consumers also must want to use it."},{"_id":"JPTCWJIKHVDA7IK62XJJRPUMBE","additional_properties":{},"type":"text","content":"That makes dosage form, delivery technology, taste, convenience, and experience part of product strategy â not decisions made after the science is settled. Gummies remain important, but innovation now spans shots, stick packs, direct-to-mouth powders, and granules, gels, soft chews, functional foods and beverages, and increasingly food-like formats."}
2039,{"_id":"LL2YMUZF6NA3TEYOVPXHHAU7CI","additional_properties":{},"type":"text","content":"The shift is showing up in consumer behavior: NIQ reports that functional beverages now generate 1bn in average monthly popularity, reflecting a broader movement of wellness beyond traditional pills and powders and into everyday food and beverage experiences.²"},{"_id":"S7ZCNZSFABF35E6ZBKZFMFJUGA","additional_properties":{},"type":"text","content":"TSI think about format as a differentiator, not simply a container for the ingredients. On-the-go formats and direct-to-mouth delivery can change when and where a product fits into someoneâs life, while novel delivery technologies can create entirely new product experiences."},{"_id":"7V5PUUFQFJA6DAPNG5MUJPLL5Y","additional_properties":{},"type":"text","content":"TSIâs FZZRâ¢, for example, offers a different way to think about supplement delivery, with the options to âdrink, buzz, or chewâ. The point is not that one format is right for every consumer. It is that format itself can be part of solving the consumer need. "},{"_id":"NHDZDAAERBGO7FC2ENOPO47BT4","additional_properties":{},"type":"text","content":"Each format brings considerations around dose, stability, sensory experience, portability, and consumer preference. The development journey becomes increasingly connected:"},{"_id":"OQ4FEFV32VGVBJAL4K3NHDNQ5A","additional_properties":{},"type":"text","content":"Science â Ingredients â Formulation â Delivery â Experience â Adherence â Outcome"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/C2EA556KINFODHV6VYHQSWR24Y.jpg","licensable":false,"alt_text":"Full development journey","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Full development journey","width":831,"creditIPTC":"Provided by client","_id":"C2EA556KINFODHV6VYHQSWR24Y","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","proxyUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/C2EA556KINFODHV6VYHQSWR24Y.jpg","published":true,"resizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/C2EA556KINFODHV6VYHQSWR24Y.jpg?auth=8efbb5488a0d173e9bb83e6a313a954e79dc2297bbc1fc8267c90140925da5c4&width=300","version":0,"originalName":"NI_TSI_Multi_Full_Development_Journey.jpg","mime_type":"image/jpeg","alt_text":"Full development journey","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:13:30Z","last_updated_date":"2026-09-11T10:13:30Z","height":303,"image_type":"photograph"},{"_id":"M4VOFTMNOFG5NBZSA7DW2YHGMA","additional_properties":{},"type":"text","content":"Thinking across those layers earlier can reveal possibilities and tradeoffs that may be missed when the ingredient is selected first and the delivery experience is figured out later. The question is no longer only âwhat should be in it?â but also âhow should the consumer experience it?â."},{"level":3,"_id":"7HYJESD4A5HGDLKERBQMJU2C2M","additional_properties":{},"type":"header","content":"Solve the whole consumer problem"},{"_id":"MQD2E3RG5VF53JX624EPSGSDKA","additional_properties":{},"type":"text","content":"GLP-1s offer a timely example of what systems thinking looks like in practice. A consumer using a GLP-1 does not simply have a âweight-managementâ need. Changes in appetite and food intake can create considerations around protein, muscle preservation, fiber, hydration, micronutrient density, and digestive tolerance."},{"_id":"FVXRQ4QTSRE6NCZ33FROOVRONY","additional_properties":{},"type":"text","content":"And consumers are already trying to navigate those needs themselves. PwC foun
2039d that 80% of current GLP-1 users are piecing together their own routines with supporting products, pointing to an opportunity for more integrated wellness solutions.³"},{"_id":"F3Q2VZUM7JBWDNYMKBNYVLIIHI","additional_properties":{},"type":"text","content":"Creatine offers an interesting example. Once associated primarily with bodybuilding and sports performance, it is increasingly relevant to broader conversations around muscle health and wellness."},{"_id":"EGMUO3L47BB27NJHYOIXTCT7RY","additional_properties":{},"type":"text","content":"TSI see that evolution reflected in interest in OptiCreatineâ¢, its proprietary premium creatine platform. Its improved solubility, rapid dissolution, and reduced sedimentation open opportunities beyond the traditional scoop into formats such as chewables, fast-melt powders, effervescent pellets, and sprinkles."},{"_id":"V3VGN64AOFBU7IZ4QBWPTYLM4A","additional_properties":{},"type":"text","content":"But the Full-Stack Wellness opportunity is bigger than creatine or any single ingredient. The better question is: how is this consumerâs nutritional ecosystem changing, and where can nutrition meaningfully support that journey?"},{"_id":"C26S4F4NZRAFDHR47PNXDWEHEA","additional_properties":{},"type":"text","content":"The answer may involve macro and micro ingredients plus different formats as needs and behaviors change. That is systems thinking: start with the whole consumer problem, then build the solution around it."},{"level":3,"_id":"E6HQU6L45ZFFTJJUX25HYKQCNM","additional_properties":{},"type":"header","content":"Connect the physical and digital stack"},{"_id":"7RNAAZKIVJDDBBXEWUIXQK4YKY","additional_properties":{},"type":"text","content":"The wellness stack does not necessarily end when a product reaches the consumer. Technology is adding another layer as wearables, apps, and other digital tools generate information around activity, sleep, recovery, stress, and individual goals."},{"_id":"DKCBW7GGZFDKDFCUENYH46CZHQ","additional_properties":{},"type":"text","content":"And consumers are acting on those insights. EYâs 2026 US Consumer Health Survey found that 55% of consumers track their health data, and 82% of those who do say they changed health-related behaviors such as exercise, diet, or sleep in the past year.â´"},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg","licensable":false,"alt_text":"EY consumer health survey","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"EY consumer health survey","width":831,"creditIPTC":"Provided by client","_id":"MQ74TRAH2ZE5RCKJ5MYGTVRL7U","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","proxyUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg","published":true,"resizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/MQ74TRAH2ZE5RCKJ5MYGTVRL7U.jpg?auth=bd774f42fbffc72b9cf35cc75c4b22e51b579c3d3d779209edc7cfda01343969&width=300","version":0,"originalName":"NI_TSI_Multi_US_Consumer_Health_Survey_Data.jpg","mime_type":"image/jpeg","alt_text":"EY consumer health survey","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:18:46Z","last_updated_date":"2026-09-11T10:18:46Z","height":303,"image_type":"photograph"},{"_id":"2AX5M3RCRRGC5JPQCIFTJMKIYM","additional_properties":{},"type":"text","content":"AI may add another dimension, helping translate those signals into more personalized recommendations, product discovery, and new-product opportunities. This is where the technology origins of âfull stackâ become especially relevant:"},{"_id":"OXPCFGB3UZE4LOFKDEWB3DL3NQ","additional_properties":{},"type":"text","content":"Data â Insight â Recommendation â Science â Solution â Delivery â Behavior â Feedback â Refinement"},{"_id":"36XB3B2N6NGSTOPQPJTLC6Z4YQ","additional_properties":{},"type":"text","content":"The feedback loop may be the most interesting part. Learn more about the consumer. Identify a need. Develop or recommend a solution. Understand how it fits into their life. Then use what you learn to produce relevant outcomes."},{"_id":"MR5DQJZSXJBHNMKZQIWFZ667ZE","additional_properties":{},"type":"text","content":"Not every company needs to own every layer of the stack. Few will. Full-stack thinking isnât about owning everything. Itâs about seeing the whole picture and knowing where the right capabilities and partnerships can connect it."},{"level":3,"_id":"BE7NMJB5TRCIJG3DFLX4XBFQ4M","additional_properties":{},"type":"header","content":"What happens when we connect the stack?"},{"_id":"SN5FY3IEQFDNHBDZCDV32KGAJE","additional_properties":{}
2039,"type":"text","content":"Great science will continue to matter. So will great ingredients, formulations, formats, manufacturing, and technology. But none of these connect themselves. It takes people â with expertise, curiosity, and the ability to see across disciplines â to bring the stack together. But increasingly, some of the most interesting innovations may happen in the connections between them."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8"},"vanity_credits":{"affiliation":[]},"caption":"","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/QFALUPDXYVBIBI52I22U3TOJBI.jpg","licensable":false,"alt_text":"Multiple delivery formats","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Multiple delivery formats","width":831,"creditIPTC":"Provided by client","_id":"QFALUPDXYVBIBI52I22U3TOJBI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","proxyUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/QFALUPDXYVBIBI52I22U3TOJBI.jpg","published":true,"resizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/QFALUPDXYVBIBI52I22U3TOJBI.jpg?auth=b4fa1d4f111aa9cafc14098b668659b03a62ab77ba3fae452be45ed89437b3e8&width=300","version":0,"originalName":"NI_TSI_Multi_Delivery_Formats-2.jpg","mime_type":"image/jpeg","alt_text":"Multiple delivery formats","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-09-11T10:17:13Z","last_updated_date":"2026-09-11T10:17:13Z","height":303,"image_type":"photograph"},{"_id":"2RQBJXYTJREETJGFVYLCZGY3IQ","additional_properties":{},"type":"text","content":"Thatâs what makes Full-Stack Wellness exciting to TSI. Its work spans consumer insights, science, ingredients, synergistic systems, formulation, delivery technologies, and manufacturing. That gives us an opportunity to start with a consumer need and ask a bigger question: what could the solution look like if we werenât limited by where one part of the value chain ends and another begins?"},{"_id":"QRI7YOU5UJAPFJNKZNCJXHQHIU","additional_properties":{},"type":"text","content":"Sometimes the answer may be a science-backed combination built around a health outcome. Sometimes it may be giving a familiar ingredient new relevance through a different format or consumer experience. And sometimes it may come from connecting capabilities or ideas that havenât traditionally been connected at all."},{"_id":"BF3TNNSNTVHIRMD53BEML2JIKQ","additional_properties":{},"type":"text","content":"It is unknown where Full-Stack Wellness will lead, but thatâs what makes the conversation interesting."},{"_id":"K55SXFZ435HHDEVEGWCTEITRVY","additional_properties":{},"type":"text","content":"So, bring TSI the consumer need you are trying to solve, or the ingredient that deserves a better experience, the product that needs a rethink, or the âwhat if we tried this?â idea. "},{"_id":"PE4XUOIN2VCZHDNE53W45RVC34","additional_properties":{},"type":"text","content":"The next great wellness solution may already exist in pieces. The opportunity is connecting the right ones. Letâs see what happens when we connect the stack."},{"_id":"5BZMGF56HRAWVHLYR3FG7ZEG34","additional_properties":{},"type":"text","content":"<b>If youâll be at SupplySide Global in Las Vegas this October, come find TSI. TSI will be sharing some of the science, ingredients, formats, and ideas in progress â and would love to hear yours. </b>"},{"_id":"ZFQ6ZTPI3NCG5JX2S3HMZWYEKI","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"SOC5HG2D4FCM5LUF5B4KWRFWFE","type":"list","items":[{"_id":"GPSSBGXTHRDXLF3NESVJU2ZH4U","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Innova Market Insights. <a href=\"https://www.innovamarketinsights.com/trends/us-supplement-market-trends/\">US Supplement Market Trends: Personalized Wellness & Hybrid Growth.</a> "},{"_id":"4E3PJXWBPZE4RK5XFGFQPIE4QM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"NielsenIQ. <a href=\"https://nielseniq.com/global/en/insights/analysis/2025/blurring-wellness-boundaries-when-supplements-meet-food-and-beverage/\">Blurring Wellness Boundaries: When Supplements Meet Food and Beverage.</a>"},{"_id":"Y6N2BAASUZBMLPMABOULKNAF3U","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"PwC. The End of More: How GLP-1 Users Shop, Eat, and Seek Support. "},{"_id":"2VTKX7NKG5FOTLA757F3S4ACZE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"EY. <a href=\"https://www.ey.com/en_us/insights/health/ey-us-consumer-health-survey-2026\">EY US Consumer Health Survey 2026.</a>"}]}],"subheadlines":{"basic":"The next wave of wellness innovation isnât a single ingredient. Itâs connecting science, delivery, and technology to solve real consumer needs."},"description":{"basic":"The next wave of wellness innovation isn't a single ingredient. It's connecting science, delivery, and technology to solve real consumer needs."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"News","description":"","_id":"/News","additional_properties":{"original":{"parent":{"
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2039se considerations are becoming increasingly important for maintaining consumer confidence and regulatory trust."},{"level":3,"_id":"4YANPE6X3BCTVPZY4IWBHBB6AQ","additional_properties":{},"type":"header","content":"Regulators raise concerns over safety and consistency"},{"_id":"DDOVH4CUIVDJNNYC7VH3GQSHIM","additional_properties":{},"type":"text","content":"In Europe, Denmark moved to ban ashwagandha in 2023, citing difficulties in establishing safe intake levels. Momentum continued in 2024, when food safety authorities across multiple member states urged the European Commission to launch an Article 8 assessment, a step that could result in the continued use of ashwagandha under defined conditions of use or restrict ashwagandha use across Europe."},{"_id":"NTI3JGRQTBHCNBQEWOW4EQ2WOY","additional_properties":{},"type":"text","content":"To address these safety concerns that were raised, Dr Thomas Brendler, an internationally recognized independent botanical quality specialist, brought together a team to provide the data to address these questions head on. This work has resulted in 25 submissions, 16 accepted papers and four further under review. "},{"_id":"RZRSSRHHG5D3HNUS4SHZDRFN5Q","additional_properties":{},"type":"text","content":"âWe were able to answer most of the questions the regulators had posed, mostly pertaining to safety, but also to efficacy,â says Dr Brendler. "},{"_id":"BU3QD55HZRFXDEQ75QFVSKBLPI","additional_properties":{},"type":"text","content":"While no final decision has been made, the discussion has seen debate focus on how botanical ingredients should be assessed and regulated. For many observers, the conversation now extends to questions around standardization, transparency and evidence requirements."},{"_id":"K2LFGLXJPVHUXKOQRSNNUZ6AHM","additional_properties":{},"type":"text","content":"A core challenge, experts say, is that ashwagandha is often treated as a single, uniform ingredient Ââ despite significant variation in plant parts, extraction methods and withanolide profiles."},{"_id":"HP2T4BX7UVCHRI6VQ7P6TZQ6SQ","additional_properties":{},"type":"text","content":"âWe donât have a central description for all possible extracts and forms,â explains Dr Mark Tallon. âThat opens up a debate for each member state to act independently on labeling doseârelated restrictions. If we have a harmonization of methods, then the industry can better predict data requirements to keep ashwagandha Ââ and other botanicals Ââ on the market.â"},{"level":3,"_id":"S3M5OZTKWRH6BBX3UTPTYXHZ3M","additional_properties":{},"type":"header","content":"Standardizing testing and strengthening transparency"},{"_id":"RZOXU6XPKVBTFCEOAJ4QRG6B5Q","additional_properties":{},"type":"text","content":"Several panellists pointed to consistency in testing and ingredient characterization as a key challenge for the category. For Petra Erlandson of Alkemist Labs, the path forward begins with consistent analytical methods."},{"_id":"2GPECBQXP5GOTFQPWUG6IESRJQ","additional_properties":{},"type":"text","content":"âWhen an ingredient does not have a standardized method, or when individual labs use proprietary methods that arenât shared, itâs not surprising to get conflicting results, which can cause confusion,â she says."},{"_id":"47NBFYMPPVCVNLD2MGM7ZVS6UQ","additional_properties":{},"type":"text","content":"Transparency is equally critical. Erlandson notes that undeclared plant parts can lead to misinterpretation: âIt all comes back to transparency and appropriate specifications for the intended use,â she says."},{"_id":"RFXEOC5NYRCLNH2T3ANS3QBYNI","additional_properties":{},"type":"text","content":"Consumers, too, are raising expectations. Ethical sourcing, sustainability and traceability are increasingly influencing purchasing decisions, according to Jason Watkin of Purica. Consumers arenât just looking at the science. âThey want to know whether itâs ethically sourced Ââ thatâs a big question.â"},{"level":3,"_id":"YIWWL3PV6REIRHAE4IRPLEZNXE","additional_properties":{},"type":"header","content":"Industry initiatives aim to safeguard the category"},{"_id":"3HNLCOPTQNG7DFU6SBXAJPMSKE","additional_properties":{},"type":"text","content":"Major suppliers are stepping in to help unify standards and improve c
2039ommunication. Dr Laura Collins highlights Kerryâs efforts: âAt Kerry, weâre committed to safeguarding the ashwagandha industry as a whole. Through initiatives like <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, we provide access to peerâreviewed science and regulatory data. Weâve also joined the Ashwagandha Standards Alliance, a global coalition dedicated to advancing evidenceâbased standards.â"},{"_id":"FE2KPDQXKNGIVAUYIIWOYKYYJU","additional_properties":{},"type":"text","content":"Erlandson emphasizes that collaboration across the supply chain Ââ from farms to finishedâproduct manufacturers Ââ is essential. âWeâre all working together so consumers have trust and confidence. They should be at the heart of everything.â"},{"level":3,"_id":"CQAU2VT5AJFFJKLAE5L3ZYUA7A","additional_properties":{},"type":"header","content":"Join On Demand now"},{"_id":"57JRO53YCVAXXF6OOZ2MKDNH3I","additional_properties":{},"type":"text","content":"As regulatory reviews of ashwagandha continue to evolve, understanding the science, quality considerations and emerging expectations around standardization has never been more important. This broadcast brings together experts from across the value chain to discu
2039ss the key issues shaping the future of the category."},{"_id":"WK4Y3HVPWND4LNWCNBVIALLFNU","additional_properties":{},"type":"text","content":"<a href=\"https://www.nutraingredients.com/Events/ashwagandha-understanding-the-science-scrutiny-and-standards/\" target=\"_blank\" rel=\"\"><b>Watch: âAshwagandha: Understanding the Science, Scrutiny and Standardsâ On Demand now to learn about the latest developments in the ashwagandha category.</b></a><b> </b>"}],"subheadlines":{"basic":"A deep dive into the science behind ashwagandha, the regulatory considerations and what the future holds for the category. 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But identifying relevant biological mechanisms is only the beginning. Human evidence and meaningful, measurable outcomes matter, as do effective dose, bioavailability, stability and dosage-form fit."},{"_id":"TGTZEMAUYVFOHBJCLRNMVFM4ZM","additional_properties":{},"type":"text","content":"Together, these considerations are reshaping not only how healthspan products should be developed, but also what developers should look for in an ingredient. AstaReal® Natural Astaxanthin offers a compelling example of this new approach."},{"level":3,"_id":"4JUF473FCFDGBDI5PE2E4TTBEE","additional_properties":{},"type":"header","content":"The hallmarks of ageing: A framework, not a claims checklist"},{"_id":"D2EBHTAD25ALHFO6QMTWUTA6DM","additional_properties":{},"type":"text","content":"First proposed in 2013 and expanded in 2023, the hallmarks of ageing framework describes 12 inter-related biological processes that contribute to ageing, classified into three categories. "},{"_id":"EHLNMPKDHFCHJPBAJDJPX5MZCU","additional_properties":{},"type":"text","content":"Primary Hallmarks represent sources of cellular damage that accumulate over time. Antagonistic hallmarks reflect responses to that damage that may initially be adaptive or protective but can become detrimental when sustained or dysregulated. Integrative hallmarks arise as the downstream effects of these processes converge, contributing more directly to declining tissue homeostasis, function and resilience.<sup>1,2</sup>"},{"_id":"HYM6UXGQRNFJPLOUKSLHYFI5KE","additional_properties":{},"type":"text","content":"Importantly, the 12 hallmarks should not be viewed as independent ageing processes. Their classification reflects a broader progression from cellular damage, through biological responses to that damage, to increasingly systemic and functional consequences. "},{"_id":"JT6LJDP4QJEX7LNWBQTDIMKM5E","additional_properties":{},"type":"text","content":"At the same time, the hallmarks interact across categories, creating feedback and reinforcing effects throughout the ageing process, as shown below in Figure 1."},{"_id":"IQHWB4IBRRB3ZOVPJVXI3QIBB4","additional_properties":{},"type":"text","content":"Together, the hallmarks provide a biological map for understanding the complex biology of ageing. But to read that map dynamically, it is important to understand n
2039ot only which hallmarks are involved, but how they evolve over time and interact with one another."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8"},"vanity_credits":{"affiliation":[]},"caption":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OE2HL5WITBGDFACMNYAX2QZB5A.png","licensable":false,"alt_text":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","width":831,"creditIPTC":"Provided by client","_id":"OE2HL5WITBGDFACMNYAX2QZB5A","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","proxyUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OE2HL5WITBGDFACMNYAX2QZB5A.png","published":true,"resizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/OE2HL5WITBGDFACMNYAX2QZB5A.png?auth=93bd9ed42a49985caf4903c9e574f2ff2f7caba6f9bf4e26299f66cc17abd0c8&width=300","version":0,"originalName":"Figure1.png","mime_type":"image/png","alt_text":"Figure 1. The hallmarks of ageing: A biological map for understanding ageing and healthspan","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:34:13Z","last_updated_date":"2026-08-21T15:34:13Z","height":303,"image_type":"photograph"},{"level":3,"_id":"FG2XWOEQWVF2XCSNVI7HU6BXWE","additional_properties":{},"type":"header","content":"Rethinking product development in the healthspan era"},{"_id":"BA2DEQ3KQNCSZJE7O73JSGXU2U","additional_properties":{},"type":"text","content":"The hallmarks of ageing framework highlights an important consideration for healthspan product development: changes in ageing biology may begin before functional decline becomes apparent. "},{"_id":"AI665BBOMFBQZPASL5BURW6LFA","additional_properties":{},"type":"text","content":"Healthspan nutrition is therefore not only about responding to age-related decline, but also about supporting the underlying biology that helps maintain function and resilience over time."},{"_id":"5FROUHUTLRBNPG62RKNUQKIA6U","additional_properties":{},"type":"text","content":"The starting point for product development should be the healthspan objective and not an ingredient or an individual hallmark. Healthspan is multidimensional, spanning physical, cognitive and sensory function, metabolic health and resilience.<sup>3,4</sup> "},{"_id":"KMPHBZMONRBUDHF4TOWQFGOSAQ","additional_properties":{},"type":"text","content":"A broad healthspan formulation may address several complementary domains, while a more targeted product may prioritise one or two. The key is to first define the target population and the healthspan outcomes that matter for them."},{"_id":"C6ODLKULRNGDBEEIMO2SI2O7HI","additional_properties":{},"type":"text","content":"âLongevityâ itself is not a practical endpoint for most nutrition products. It must be translated into outcomes that can be studied and monitored. These priorities can then guide the identification of relevant ageing biology and the choice of clinical endpoints, biomarkers and, ultimately, ingredients and ingredient combinations."},{"level":3,"_id":"LJ7FTYLMXNDR5OTGTI4JWWOJTM","additional_properties":{},"type":"header","content":"Two gates for ingredient selection"},{"_id":"XQQPB5RJVRD2HCGQYBG6BQ3AYM","additional_properties":{},"type":"text","content":"Once the healthspan objective and relevant biology have been identified, potential ingredients need to pass through two important gates: an evidence gate and a formulation gate."}
2039,{"_id":"BJVUWIIU35GCTFXFSG77GQ72SY","additional_properties":{},"type":"text","content":"The evidence gate asks whether there is credible human evidence to support an ingredientâs relevance to the intended healthspan objective. Mechanistic and preclinical evidence can establish biological plausibility, but developers should also consider whether the ingredient has been studied in a relevant population, at an achievable dose and against outcomes relevant to the intended objective.<sup>5</sup>"},{"_id":"UPEPRY7GQJC4RFBT7N7JCIZ73A","additional_properties":{},"type":"text","content":"The formulation gate asks whether that evidence can be translated into a viable product. Can an evidence-based dose be delivered in the intended dosage form? Is the ingredient sufficiently bioavailable and stable? Is it compatible with other ingredients?"},{"_id":"TC33BPDVYNDZ7KRDADN2LRQ47E","additional_properties":{},"type":"text","content":"Passing one gate does not guarantee passing the other. A compelling biological rationale without relevant human evidence may be insufficient to support ingredient selection. Equally, strong clinical evidence may have limited practical value if the evidence-based dose or formulation cannot realistically be delivered in the intended product."},{"_id":"J2KUDPP2WZHUBNFOR7FXBZTSZA","additional_properties":{},"type":"text","content":"Together, these two gates provide a practical bridge between the biology of ageing and the development of credible healthspan products â helping ensure that ingredient selection is guided not simply by mechanistic potential, but by human evidence and real-world formulation feasibility."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35"},"vanity_credits":{"affiliation":[]},"caption":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OWSM7M23Y5HCJBHO6ZPHWATINI.png","licensable":false,"alt_text":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","width":831,"creditIPTC":"Provided by client","_id":"OWSM7M23Y5HCJBHO6ZPHWATINI","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","proxyUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/OWSM7M23Y5HCJBHO6ZPHWATINI.png","published":true,"resizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/OWSM7M23Y5HCJBHO6ZPHWATINI.png?auth=65545f03895ff758f8a572fbc8bc185ae133d4129d883852923eafd6b1481b35&width=300","version":0,"originalName":"Figure2.png","mime_type":"image/png","alt_text":"Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:34:49Z","last_updated_date":"2026-08-21T15:34:49Z","height":303,"image_type":"photograph"},{"_id":"ODMAYFXY4FBD3M7FHNU65QPT2Q","additional_properties":{},"type":"text","content":"<b>Figure 2. From healthspan objective to a viable product: A science-guided framework for healthspan product development</b>"},{"level":3,"_id":"H6XARJUGOBGOTN3BOOOAJAF5KA","additional_properties":{},"type":"header","content":"From biological relevance to human evidence"},{"_id":"GUQU6TI5HRBDPOAIPIQFSSHNZU","additional_properties":{},"type":"text","content":"Healthspan-oriented product development places new demands on ingredient selection. The strongest candidates are those whose biological actions are relevant to the intended healthspan objective and are supported by evidence that these actions translate into outcomes in people. "},{"_id":"CFXOG53HJJGVJJNNQ4WKSKS5PA","additional_properties":{},"type":"text","content":"AstaReal natural astaxanthin provides a foun
2039dation to bring these two dimensions together: broad biological relevance across inter-linked processes associated with healthy ageing, supported by an extensive body of human clinical research."},{"_id":"RH7VRFAN7BDOXJJQTOGNFFOQY4","additional_properties":{},"type":"text","content":"Mechanistic and preclinical research has shown that astaxanthin interacts with multiple biological processes involved in cellular resilience and homeostasis, including mitochondrial function, energy metabolism, oxidative stress responses, inflammation, nutrient sensing and cellular quality control. "},{"_id":"FAY2NOFZP5AM7HM37XOFSM5BJI","additional_properties":{},"type":"text","content":"Importantly, research is beginning to reveal how these processes are closely associated. For example, AstaReal astaxanthin has been shown to activate AMPK signaling, with downstream upregulation of SIRT1 and PGC-1α thereby enhancing mitochondrial biogenesis and energy metabolism.<sup>6</sup>"},{"_id":"KHW4KAD3NZCDTIWYIZQVHQ6MSI","additional_properties":{},"type":"text","content":"Other research using AstaReal astaxanthin suggests that regulation of IGF-1/Akt/FoxO3a and IGF-1/Akt/mTOR signaling may contribute to the induction of autophagy.<sup>7</sup> Together, these findings illustrate how astaxanthin can influence such interacting biological networks rather than isolated pathways â providing mechanistic links to multiple hallmarks of ageing. "},{"_id":"DZSS7VLHBZHURPH4VYZBT4KBGA","additional_properties":{},"type":"text","content":"Importantly, this biological relevance is accompanied by substantial human evidence. AstaReal astaxanthin has been investigated in more than 85 human clinical studies across multiple physiological functions and life stages, including physical performance and recovery, metabolic health, cognition, vision and skin health. "},{"_id":"XGEMWBKZJRC5DHMAGN2REIXJRU","additional_properties":{},"type":"text","content":"Taken together, mechanistic insights and evidence from human studies provide a strong scientific foundation for the use of AstaReal astaxanthin as a multifunctional ingredient in healthspan-oriented product development, linking the biology of ageing with multiple aspects of healthy function across the lifespan."},{"level":3,"_id":"RAWKGC4ZHVGPZIP7TTPHDUNDR4","additional_properties":{},"type":"header","content":"Build around the healthspan objective"},{"_id":"Y7T7GTOJKFDCRKEATBFG4SZHHM","additional_properties":{},"type":"text","content":"This broad scientific foundation also creates flexibility in formulation design. Starting with the intended healthspan objective, developers can identify the biological processes and functional outcomes most relevant to that objective and then build a formulation around them. "},{"_id":"ILCZZPIEWVBPHAUU5WSRJ45ZBA","additional_properties":{},"type":"text","content":"AstaReal astaxanthin can serve as a multifunctional foundation, with complementary ingredients selected to support additional or overlapping biological needs."},{"_id":"6YZDHJOR7JDABI6BKW3P4NMHSY","additional_properties":{},"type":"text","content":"For example, a formulation focused on mobility and muscle function may combine astaxanthin with protein, vitamin D or omega-3 fatty acids, while a vision-focused formulation may incorporate lutein. "},{"_id":"KJ2BOXKVD5BDROF7RWCKVU2ZF4","additional_properties":{},"type":"text","content":"Metabolic or cognitive formulations can similarly be designed around the biology most relevant to their intended outcomes. The aim is to build a rational combination in which complementary ingredients and mechanisms work together toward a clearly defined healthspan objective."},{"owner":{"sponsored":false,"id":"williamreed"},"address":{},"syndication":{},"auth":{"1":"762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d"},"vanity_credits":{"affiliation":[]},"caption":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","source":{"system":"photo center","edit_url":"","additional_properties":{"editor":"photo center"}},"taxonomy":{"associated_tasks":[]},"type":"image","version":"0.10.9","url":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/GSP3YNL27RHPTNXXKKR4KQL74A.png","licensable":false,"alt_text":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","credits":{"affiliation":[{"name":"Provided by client","type":"author"}]},"subtitle":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","width":831,"creditIPTC":"Provided by client","_id":"GSP3YNL27RHPTNXXKKR4KQL74A","additional_properties":{"fullSizeResizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","proxyUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","link":"","originalUrl":"https://cloudfront-eu-central-1.images.arcpublishing.com/williamreed/GSP3YNL27RHPTNXXKKR4KQL74A.png","published":true,"resizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d","ingestionMethod":"manual","thumbnailResizeUrl":"/resizer/v2/GSP3YNL27RHPTNXXKKR4KQL74A.png?auth=762f2b85ee9e2763e82eed5a1ad7271ffd021a64e955bc470e1415612a680a2d&width=300","version":0,"originalName":"Figure3.png","mime_type":"image/png","alt_text":"Figure 3: Building healthspan formulations around AstaReal astaxanthin","restricted":false,"template_id":442,"galleries":[]},"created_date":"2026-08-21T15:35:24Z","last_updated_date":"2026-08-21T15:35:24Z","height":303,"image_type":"photograph"},{"level":3,"_id":"DCPHTBEH5ZF4PB5Z6YG2FNZ75M","additional_properties":{},"type":"header","content":"Beyond the ingredient: Effective delivery"},{"_id":"2H65VH2X2FEDRKBXCVA3433G3M","additional_properties":{},"type":"text","content":"Scientific evidence and ingredient selection are only part of translating healthspan science into a successful finished product. Effective delivery also matters. Astaxanthin is naturally lipophilic and is typically formulated in oil-based formats, which can limit its use in other dosage forms. Bioavailability is also an important consideration, as effective absorption depends on how astaxanthin is formulated and delivered."},{"_id":"5ZLJGGHR4FBGBEYFGFVLXHVUBQ","additional_properties":{},"type":"text","content":"AstaReal CLEAR is an astaxanthin emulsion designed to improve dispersibility and enhance bioavailability of astaxanthin<b> </b>by applying delivery technology, while expanding formulation possibilities beyond conventional oil-based capsules."},{"_id":"PVQPIG2XEBAJBJVBNBYVUCVWOI","additional_properties":{},"type":"text","content":"This demonstrates how ingredient science and formulation technology can work together: scientific evidence establishes relevance to the intended healthspan objective, while effective delivery helps translate that evidence into practical and versatile product solutions."},{"level":3,"_id":"6RMPPZ6MBNF2JAMHKF3TRCJUEA","additional_properties":{},"type":"header","content":"Bringing healthspan science into practice"},{"_id":"LOP4CRKZDVBNRFTT2Z3UERH3N4","additional_properties":{},"type":"text","content":"The opportunity in healthspan nutrition is not simply to add more âlongevity ingredientsâ, but to design products around a defined objective, relevant ageing biology, human evidence and practical delivery. AstaReal natural astaxanthin shows what this looks like in practice: a clear mechanistic rationale, a growing body of human research, and a formulation profile that translates into real products. "},{"_id":"QJFZ4AEJZ5HGRL2HOPVWPZ7MHE","additional_properties":{},"type":"text","content":"The combination of robust clinical evidence and versatility across delivery formats is what makes AstaReal astaxanthin a compelling hero ingredient for healthspan-focused development."},{"_id":"2DREQAPMUZEKRHIMCMCUXLGE7U","additional_properties":{},"type":"text","content":"<a href=\"https://astareal.com/en/\" target=\"_blank\" rel=\"\"><b>For more information on AstaReal® Astaxanthin science and its range of products, contact the team here.</b></a>"},{"_id":"XEMGTOFDWZEHLJZLPWHDPHUYMY","additional_properties":{},"type":"text","content":"<b>References </b>"},{"list_type":"ordered","_id":"46Z2YY4EURGUFJFDCWVBU62GJI","type":"list","items":[{"_id":"D3LK6PEUCNF3HMJSNZ5TYC3V5Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"López-OtÃn, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/23746838/\">The hallmarks of aging.</a> Cell. 2013;153(6):1194â1217. "},{"_id":"ZEC7WH7Q6NFYJP3GHUQGQASP3Q","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"López-OtÃn, C.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/36599349/\">Hallmarks of aging: An expanding universe.</a> Cell. 2023;186(2):243â278. "},{"_id":"2ZJTRXH4ORFLJJNDWTSSWRSGV4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"World Health Organization. <a href=\"https://www.who.int/news-room/questions-and-answers/item/healthy-ageing-and-functional-ability\">Healthy ageing and functional ability.</a> "},{"_id":"WSZUXL3RBFBFDE6NWALTY375SY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Kaufman, MW.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39554957/\">Nutritional Supplements for Healthy Aging: A Critical Analysis Review.</a> Am J Lifestyle Med. 2024;19(3):346â360. "},{"_id":"KZV7PFMVGZHGDDMANR3RWQFATY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Vaiserman, A.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC5520340/\">Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives.</a> J Transl Med. 2017;15:160. "},{"_id":"BVRLWR6SSNGTHPXWFGT4H2PCBQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Nishida, Y.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/32003547/\">Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway.</a> J Cachexia Sarcopenia Muscle. 2020;11(1):241â258. "},{"_id":"22KUATUG2JC7ZP7WKTPO5XONPM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Fu, M.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/35385370/\">Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism.</a> Nutr Neurosci. 2023;26(5):445â455. "}]}],"subheadlines":{"basic":"How can healthspan nutrition be designed around a defined objective, relevant ageing biology, human evidence and practical delivery?"},"description":{"basic":"How can healthspan nutrition be designed around a defined objective, relevant ageing biology, human evidence and practical delivery?"},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News","parent":{"default":"/"},"_website":"nutraingredients-v2","parent_id":"/","name":"News","description":"","_id":"/News","additional_properties":{"original":{"parent":{"
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2039,{"_id":"5NEDJ35BOVHQNB4NNFXCJZJQIA","additional_properties":{},"type":"text","content":"The plantâs roots and leaves contain bioactive compounds known as withanolides, which have been studied for their potential role in areas including stress reduction, sleep support, cognitive health, and sports performance. As a result, it is now used widely across supplements, functional foods, and beauty products."},{"_id":"6PJO2VXOUJGRPPXKKQVJUFHIBM","additional_properties":{},"type":"text","content":"Market analysts expect consumer interest in supplements containing the adaptogenic herb to continue to grow, with projections suggesting the category will reach $2.01bn globally by 2035, up from $837.5m in 2025, a CAGR of 9.17%.<sup>1</sup>"},{"_id":"XJCUSORPNRERDHMWR2PJMEYZZY","additional_properties":{},"type":"text","content":"Much of the scientific research surrounding ashwagandha has focused on both the safety of the ingredient, and from a mechanistic perspective, its interaction with the hypothalamic-pituitary-adrenal (HPA) axis, the bodyâs central stressâresponse system. Research has explored the botanicalâs support for stress management, sleep, and cognitive health, although differences in extract composition and standardization approaches remain an ongoing topic of discussion within the category."},{"level":3,"_id":"FUC574ZVOFGUJIEWOPSWCV3C3U","additional_properties":{},"type":"header","content":"Regulatory questions "},{"_id":"RHMVWAC6UBHGHN25ZRE2MSZRYE","additional_properties":{},"type":"text","content":"Alongside its commercial success, ashwagandha is facing intensifying scrutiny from authorities. Concerns have been raised by regulators around long-term safety, potential thyroid and reproductive effects, and uncertainty over safe intake levels. The US National Center for Complementary and Integrative Health has also noted rare cases of liver injury.<sup>2</sup>"},{"_id":"JVTQN3EHCJBFVIG32WY5TIO2QQ","additional_properties":{},"type":"text","content":"Denmark introduced restrictions on ashwagandha in 2023 following concerns around establishing safe intake thresholds. In 2024, national food safety authorities across Europe urged the European Commission to initiate an Article 8 assessment â a move that may confirm ashwagandhaâs safety and reassure national regulators, or potentially lead to EU-wide guidelines or restrictions. "},{"_id":"S2JB43T4UNGA3GG7CI23RM7O6M","additional_properties":{},"type":"text","content":"The TGA in Australia concluded that there was a very rare risk of liver injury with ashwagandha and advises consumers to be aware of potential gastrointestinal adverse effects and the possible risk of liver injury in very rare cases.<sup>3</sup> "},{"_id":"OZ7X7RQ7NRHPXKTP2VPWIIE3E4","additional_properties":{},"type":"text","content":"Industry stakeholders point to variability in extracts with plant part, extraction method, characterization and product specific substantiation all adding to this, creating challenges when comparing products and interpreting resesearch findings.<sup>4</sup> These differences sit at the heart of ongoing discussions around standardization, product quality, and how evidence should be interpreted across the category."},{"_id":"QPOQRZJFGFGNHIB6EDWCY2SRDM","additional_properties":{},"type":"text","content":"For manufacturers, this creates questions around formulation strategy, market access, and future investment decisions. The result is a fragmented landscape where brands must navigate differing national interpretations, evolving safety assessments and extract-specific considerations. "},{"level":3,"_id":"NLGQE7Y5BJA5ZNU4GH3ZSZJQKM","additional_properties":{},"type":"header","content":"Industry response: Clarity, quality, and communication"},{"_id":"3ZUODKC4WFDWXLEFOZAOIF3HW4","additional_properties":{},"type":"text","content":"With regulatory uncertainty mounting, industry stakeholders are stepping forward to address gaps in scientific communication and quality assurance. In May 2026 an industry led initiative, <a href=\"https://safeguardashwagandha.com/\" target=\"_blank\" rel=\"\" title=\"https://safeguardashwagandha.com/\">Safeguard Ashwagandha</a>, was launched with support from leading manufacturer Kerry, this platform is designed to centralize peer-reviewed research, ensure public access to safety data, provide updates on regulatory developments and a live regulatory tracker outlining permitted uses across global markets."},{"_id":"CDICVCWJCFAQ3D5DR5G3RDNJA4","additional_properties":{},"type":"text","content":"The initiative reflects a broader industry push toward standardization â particularly around withanolide content, extraction methods, analytical testing, and traceability. As the category expands, many stakeholders argue that greater alignment around these will play an important role in supporting consumer trust and regulatory compliance. Indeed, the future of the category may depend on whether industry can build greater alignment."},{"level":3,"_id":"SDXUW3L4UBDELOHZRJCHZ37IAY","additional_properties":{},"type":"header","content":"Join our event"},{"_id":"34PEMIHLJFA3DCSPDMWHEXUUGQ","additional_properties":{},"type":"text","content":"In partnership with Kerry, NutraIngredients is hosting a Spotlight O
2039n <b>â</b>Ashwagandha: Understanding the Science, Scrutiny and Standardsâ. The broadcast will examine whether greater alignment around science, standards, and quality can help the industry navigate regulatory scrutiny to support the categoryâs growth. "},{"level":3,"_id":"FGRANCFHTJFUFHVCJDKTMETLME","additional_properties":{},"type":"header","content":"During the Spotlight broadcast you will:"},{"list_type":"unordered","_id":"4R6JU5VY2BC6XIWXA2INV6V2TU","type":"list","items":[{"_id":"IS2MB4NPDBGRFGMW36S7NAUE4I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Explore the clinical science behind ashwagandha with botanical quality and standardization expert Dr Thomas Brendler. "},{"_id":"A4QQ3FVKTJD7LLKO44J6EFFL5Y","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Gain clarity on the regulatory pressures surrounding the ingredient from food lawyer Dr Mark Tallon. "},{"_id":"WO7XLE6IRJEJXDTTCUVAZYPCXQ","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how standardization and analytical testing can support greater consistency across botanical products from Petra Erlandson, VP of Sales at Alkemist Labs. "},{"_id":"IXGM5XPNIRFE7ICR3YPK7XXF7I","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"See how brands are merging traditional knowledge with modern clinical validation with Dr Laura Collins, RDA Director of Cognitive Health at Kerry."},{"_id":"OASJNY34OVALVA4KGGU27FNULE","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Learn how brands are approaching ingredient selection, quality assurance and consumer demand in an increasingly scrutinized category with Jason Watkin, CEO of Canadian wellness brand Purica."}]},{"_id":"QFMPZQK2KVE7TKILJRYKXB7JHU","additional_properties":{},"type":"text","content":"<a href=\"https://tinyurl.com/PrePromoKerry\" target=\"_blank\" rel=\"\" title=\"https://tinyurl.com/PrePromoKerry\"><b>Register now to watch </b><i><b>Ashwagandha: Understanding the Science, Scrutiny and Standards</b></i><b> at 3pm BST, 4pm CEST, 9am CDT on 17 September 2026</b></a>"},{"_id":"B2GOOM25YFEERJNJPNPQNVZAFU","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"TPFA7UOJJRGVPHXX3AZP75YSCM","type":"list","items":[{"_id":"KERK755IVFDZNORE3IUNCPXRX4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Pandey, D. <a href=\"https://www.precedenceresearch.com/ashwagandha-market\" target=\"_blank\" rel=\"\" title=\"https://www.precedenceresearch.com/ashwagandha-market\">Ashwagandha Market Size, Share and Trends 2026 to 2035</a>, Precedence Research."},{"_id":"J4W44QJPBVBCLNO7OL4QNTR4V4","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"National Center for Complementary and Integrative Health, <a href=\"https://www.nccih.nih.gov/health/ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.nccih.nih.gov/health/ashwagandha\">Health Info, Ashwagandha</a>."},{"_id":"2TDHDVFTRVET5O5HTX3D3SJKFI","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Australian Government, Department of Disability, Health and Ageing, <a href=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\" target=\"_blank\" rel=\"\" title=\"https://www.tga.gov.au/safety/safety-monitoring-and-information/safety-alerts/herbal-preparations-containing-withania-somnifera-withania-ashwagandha\">Herbal preparations containing Withania somnifera (Withania, Ashwagandha)</a>."},{"_id":"NWOV3HV2NVH23LHAJMGGOBOOAY","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Domián, B. M.; et al. <a href=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\" target=\"_blank\" rel=\"\" title=\"https://www.sciencedirect.com/science/article/pii/S2772502226007821\">The ashwagandha paradox: a mixed-methods analysis of regulatory gaps, deceptive vendors and safety risks in the European online market</a>. Applied Food Research, Volume 6, Issue 2, December 2026, 102444."}]}],"subheadlines":{"basic":"As consumer demand for ashwagandha increases, discussions around standards, quality, and regulatory consistency are becoming increasingly prominent. 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Consumers and formulators alike require assurance that a natural extract is safe for regular, long-term consumption. To establish this baseline of trust, Tri-Low underwent rigorous toxicological evaluations, including acute toxicity testing under OECD 423 guidelines and sub-chronic toxicity testing under OECD 408 guidelines.<sup>3</sup>"},{"_id":"BIAPYDLPTVGWRAY4XD67OFZFTQ","additional_properties":{},"type":"text","content":"In these repeated-dose studies, the evaluations revealed no visible adverse effects, even at extrapolated human-equivalent intake levels significantly higher than typical recommended servings. This robust safety profile provides valuable peace of mind for both formulators designing consumer products and individuals incorporating the ingredient into their daily wellness regimens. 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2039-care and the empowering choice to nourish the body with scientifically supported natural ingredients. "},{"_id":"7GWPRJDMCJCUZPW64UYRLHX524","additional_properties":{},"type":"text","content":"Tri-Low embodies this positive philosophy by connecting a familiar, cherished botanical with modern scientific validation."},{"_id":"Z55DFSO4URECNBM6F6QKQ4CDEY","additional_properties":{},"type":"text","content":"It bridges the gap between personal wellness goals and global nutritional standards, offering a harmonious blend of heritage and data. For brands looking to craft transparent, engaging, and science-led communications, standardized amla extract provides a compelling story of natural balance and vitality."},{"_id":"SYHVBPS3NVHYNACXA4LP7T3M7U","additional_properties":{},"type":"text","content":"<b>Exploring further</b>"},{"_id":"L2H2MNY3TRGMJJG7EUI5ENRC2Y","additional_properties":{},"type":"text","content":"For those interested in delving deeper into the scientific evaluations, bioactive profiles and research methodologies surrounding standardised amla extract, <a href=\"https://arjunanatural.com/cardiovascular-health-2/\" target=\"_blank\" rel=\"\">download the whitepaper on comprehensive lipid management here.</a> "},{"_id":"ALRO5YQICVAEXCNLCPILHIHUDA","additional_properties":{},"type":"text","content":"<b>References</b>"},{"list_type":"ordered","_id":"N4JYHPIKZFDBFF7XXQ3REUUII4","type":"list","items":[{"_id":"E3WTK34RSRGMVP2Y3FVAJLCCLA","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Upadya H.; et al. <a href=\"https://pubmed.ncbi.nlm.nih.gov/30670010/\" target=\"_blank\" rel=\"\">A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia.</a> BMC Complement Altern Med. 2019 Jan 22;19(1):27. "},{"_id":"WSL3TJ4RSRCKJLTZWOLQONFORM","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Suhag, D.; et al. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC13148805/\" target=\"_blank\" rel=\"\">Effect of Amla Extract on Body Mass Index, Waist Circumference, Total Body Fat, Visceral Fat, Skeletal Mu
2039scle Mass, Body Age, and Related Parameters: A Randomized, Open-Label Clinical Study in Obese Participants.</a> Complementary Medicine Research. 2025; 32.4: 326-340."},{"_id":"62HMSQ5QSNDJXNMPYOEUOTHTJU","additional_properties":{"indent":0},"alignment":"left","type":"text","content":"Benny, M.; et al. <a href=\"https://rjptonline.org/AbstractView.aspx?PID=2024-17-10-37\" target=\"_blank\" rel=\"\">Safety Evaluation of Amla extract by Acute and Sub-chronic exposure in rats</a>. Research Journal of Pharmacy and Technology 17, no. 10 (2024): 4887-4894."}]}],"subheadlines":{"basic":"Standardised amla extract may provide support for cardiovascular health, new study shows."},"description":{"basic":"Standardised amla extract may provide support for cardiovascular health, new study shows."},"language":"en-GB","source":{"system":"composer","name":"williamreed","source_type":"staff"},"taxonomy":{"sections":[{"path":"/News/Promotional-features","parent":{"default":"/News"},"_website":"nutraingredients-v2","parent_id":"/News","name":"Partner Feature","description":null,"_id":"/News/Promotional-features","additional_properties":{"original":{"parent":{"default":"/News","main-navigation":"/News"},"_admin":{"alias_ids":["/News/Promotional-features"]},"navigation":{"nav_title":"Partner Feature","root_section":"false","type":"news"},"site":{"site_description":null,"site_title":null},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Partner Feature","_id":"/News/Promotional-features","order":{"default":7,"main-navigation":7}}},"_website_section_id":"nutraingredients-v2./News/Promotional-features","type":"section","version":"0.6.0"},{"path":"/Health-conditions/Healthy-aging","parent":{"default":"/Health-conditions"},"_website":"nutraingredients-v2","parent_id":"/Health-conditions","name":"Healthy aging","description":"","_id":"/Health-conditions/Healthy-aging","additional_properties":{"original":{"parent":{"default":"/Health-conditions","main-navigation":"/Health-conditions"},"website":"nutraingredients-v2","navigation":{"nav_title":"Healthy aging","root_section":"false","type":"news"},"_admin":{"alias_ids":["/Health-conditions/Healthy-aging"]},"site":{"site_description":"","site_title":""},"inactive":false,"node_type":"section","_website":"nutraingredients-v2","name":"Healthy aging","_id":"/Health-conditions/Healthy-aging","regi
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