https://www.physiciansweekly.com/_next/static/chunks/pages/navigator/[slug]-e8464482c4b746e9.js

1(self.webpackChunk_N_E=self.webpackChunk_N_E||[]).push([[2145],{3838:e=>{e.exports={areaLabel:"AreaLabel_areaLabel__O1ina",areaLabelHovered:"AreaLabel_areaLabelHovered__qXkbw",areaLabelActive:"AreaLabel_areaLabelActive__NxJBI",areaLabelText:"AreaLabel_areaLabelText__MPncI"}},8242:e=>{e.exports={overlay:"CancerTypeOverlay_overlay__ztwYJ",slideUp:"CancerTypeOverlay_slideUp__3RenA",header:"CancerTypeOverlay_header__XNxT6",title:"CancerTypeOverlay_title__SO6VC",closeButton:"CancerTypeOverlay_closeButton__mfHyr",content:"CancerTypeOverlay_content__RJfMB",buttonsList:"CancerTypeOverlay_buttonsList__X4l13",cancerButton:"CancerTypeOverlay_cancerButton__DvaQW",cancerButtonSelected:"CancerTypeOverlay_cancerButtonSelected__z8QGS",cancerButtonText:"CancerTypeOverlay_cancerButtonText__0BTDM",cancerButtonArrow:"CancerTypeOverlay_cancerButtonArrow__5YXj1"}},9462:e=>{e.exports={tagline:"NavigatorTagline_tagline__zAKrm"}},13588:e=>{e.exports={hotspot:"HotspotIndicator_hotspot__AwnY3",pulse:"HotspotIndicator_pulse__a1M4d",ripple:"HotspotIndicator_ripple__OM0Vg",hotspotHovered:"HotspotIndicator_hotspotHovered__P1nxP",hotspotActive:"HotspotIndicator_hotspotActive__xkNUy"}},26258:(e,a,t)=>{(window.__NEXT_P=window.__NEXT_P||[]).push(["/navigator/[slug]",function(){return t(80960)}])},29838:e=>{e.exports={root:"TabbedNavigatorPage_root__dTcVO",navigatorBanner:"TabbedNavigatorPage_navigatorBanner__ReVyq",mobileLayout:"TabbedNavigatorPage_mobileLayout__iSmVX",migraineDesktopLayout:"TabbedNavigatorPage_migraineDesktopLayout__hX7Rm",adsSidebar:"TabbedNavigatorPage_adsSidebar__fZo3Y",typeTabs:"TabbedNavigatorPage_typeTabs__3g_No",gridTabs:"TabbedNavigatorPage_gridTabs__7WC6v",tabsContent:"TabbedNavigatorPage_tabsContent__MJpTC",tabbedDesktopShell:"TabbedNavigatorPage_tabbedDesktopShell__owWRr",tabbedLeftRail:"TabbedNavigatorPage_tabbedLeftRail__RAAk6",tabbedFigureColumn:"TabbedNavigatorPage_tabbedFigureColumn__yWnmV",tabbedStackColumn:"TabbedNavigatorPage_tabbedStackColumn___MON8",mapImage:"TabbedNavigatorPage_mapImage__hw94D",layerOverlay:"TabbedNavigatorPage_layerOverlay__TmwZR",figureMapArea:"TabbedNavigatorPage_figureMapArea__OMBbW",viewLegendButton:"TabbedNavigatorPage_viewLegendButton__0vzdh",viewLegendButtonTopRight:"TabbedNavigatorPage_viewLegendButtonTopRight__VxPqV",viewLegendLabel:"TabbedNavigatorPage_viewLegendLabel__qgSNS",viewLegendIcon:"TabbedNavigatorPage_viewLegendIcon__fvaYf",mobileBody:"TabbedNavigatorPage_mobileBody__ZOzC3",mobileBodyMapWrapperTabbed:"TabbedNavigatorPage_mobileBodyMapWrapperTabbed__VlCxv",mobileTypePickerShell:"TabbedNavigatorPage_mobileTypePickerShell__k480q",mobileState2:"TabbedNavigatorPage_mobileState2__Fp5oj",mobilePhaseRow:"TabbedNavigatorPage_mobilePhaseRow__8L9V5",mobilePhaseLabel:"TabbedNavigatorPage_mobilePhaseLabel___5QKp",mobilePhaseTimeline:"TabbedNavigatorPage_mobilePhaseTimeline__eoOlg",mobileSheet:"TabbedNavigatorPage_mobileSheet__joTVK",mobileSheetCollapsed:"TabbedNavigatorPage_mobileSheetCollapsed__zmvUH",mobileSheetExpanded:"TabbedNavigatorPage_mobileSheetExpanded__gTCcf",mobileSheetCollapsedBody:"TabbedNavigatorPage_mobileSheetCollapsedBody__fLtFm",mobileSheetHeader:"TabbedNavigatorPage_mobileSheetHeader__91EAV",mobileSheetHandle:"TabbedNavigatorPage_mobileSheetHandle__R36hn",mobileSheetTitle:"TabbedNavigatorPage_mobileSheetTitle__QWkDM",mobileSheetHint:"TabbedNavigatorPage_mobileSheetHint__Yi84f",mobileSheetBackdrop:"TabbedNavigatorPage_mobileSheetBackdrop__M8pMV",tabbedSheetSlideUp:"TabbedNavigatorPage_tabbedSheetSlideUp__Dfgml",mobileSheetExpandedHeader:"TabbedNavigatorPage_mobileSheetExpandedHeader___D_UO",mobileSheetExpandedTopRow:"TabbedNavigatorPage_mobileSheetExpandedTopRow__GY0yy",mobileSheetContent:"TabbedNavigatorPage_mobileSheetContent__Fw7Ed",mobileTypeStackOverlay:"TabbedNavigatorPage_mobileTypeStackOverlay__eJJU7",migraineDrawerStack:"TabbedNavigatorPage_migraineDrawerStack__Brh7_",migraineDrawerEmpty:"TabbedNavigatorPage_migraineDrawerEmpty__U9JDW",empty:"TabbedNavigatorPage_empty__O9mvk",desktopLayout:"TabbedNavigatorPage_desktopLayout__vqeLx",phaseRow:"TabbedNavigatorPage_phaseRow__9NCXy",phaseLabel:"TabbedNavigatorPage_phaseLabel__4fAqw",phaseTimeline:"TabbedNavigatorPage_phaseTimeline__BZ_Cf",subtypeRow:"TabbedNavigatorPage_subtypeRow__ySv8N",subtypeLabel:"TabbedNavigatorPage_subtypeLabel__B_c_e",subtypePills:"TabbedNavigatorPage_subtypePills__6cguX",subtypePill:"TabbedNavigatorPage_subtypePill__N6Psy",

1subtypePillActive:"TabbedNavigatorPage_subtypePillActive__vrzMx"}},33170:e=>{e.exports={root:"MigraineNavigatorPage_root__dftDQ",tabsContent:"MigraineNavigatorPage_tabsContent__R18qg",areaIntro:"MigraineNavigatorPage_areaIntro__Rb8SW",areaIntroTitle:"MigraineNavigatorPage_areaIntroTitle__gdcFp",areaIntroDescription:"MigraineNavigatorPage_areaIntroDescription__Zvkku",typeTabs:"MigraineNavigatorPage_typeTabs__npTlt",migraineDesktopLayout:"MigraineNavigatorPage_migraineDesktopLayout__8bEHl",gridTabs:"MigraineNavigatorPage_gridTabs__btm10",mobileStack:"MigraineNavigatorPage_mobileStack__3kC5L",tabPanel:"MigraineNavigatorPage_tabPanel__ExhmA",mapImageRow:"MigraineNavigatorPage_mapImageRow__NUGCO",mapImage:"MigraineNavigatorPage_mapImage__ePcVs",cancerPanelWrap:"MigraineNavigatorPage_cancerPanelWrap__OITuc",cancerPanel:"MigraineNavigatorPage_cancerPanel__VTOY2",loading:"MigraineNavigatorPage_loading__eiE5Z",migraineDrawerStack:"MigraineNavigatorPage_migraineDrawerStack__KoRZK",migraineDrawerEmpty:"MigraineNavigatorPage_migraineDrawerEmpty__SSmiM"}},48723:e=>{e.exports={page:"navigator_page__gN4M9",pageTabbedScroll:"navigator_pageTabbedScroll__U00FT",container:"navigator_container__c7Z3o",pageTitle:"navigator_pageTitle__lED55",pageTitleImage:"navigator_pageTitleImage__2dwPK",pageSubtitle:"navigator_pageSubtitle__mZzpT",desktopLayout:"navigator_desktopLayout__dmMVt",desktopContent:"navigator_desktopContent__rOaoB",desktopContentMigraine:"navigator_desktopContentMigraine__tSFWe",adsSidebar:"navigator_adsSidebar__TEpmI",centerColumn:"navigator_centerColumn__vd6J4",imageWrapper:"navigator_imageWrapper__m23e6",cancerPanelScrollAnchor:"navigator_cancerPanelScrollAnchor__wFkCo",mobileLayout:"navigator_mobileLayout__QMlBG",mobileSection:"navigator_mobileSection__trHRh",mobileBodyMapWrapper:"navigator_mobileBodyMapWrapper__bw08c",hamburgerButtonWrapper:"navigator_hamburgerButtonWrapper__d7FsB",hamburgerButton:"navigator_hamburgerButton__r1Ugm",hamburgerButtonHidden:"navigator_hamburgerButtonHidden__mlICC",labelsHidden:"navigator_labelsHidden__jDuuh",hamburgerButtonText:"navigator_hamburgerButtonText__XBGoX",hamburgerIcon:"navigator_hamburgerIcon__5eeyQ",hamburgerTooltip:"navigator_hamburgerTooltip__SH5jx",mobileBiomarkerOverlay:"navigator_mobileBiomarkerOverlay__QYS2K",slideUp:"navigator_slideUp__ssEuK",mobileBiomarkerScrollArea:"navigator_mobileBiomarkerScrollArea__qkV_m",mobileBiomarkerHeader:"navigator_mobileBiomarkerHeader__Z3z1S",mobileBiomarkerTitle:"navigator_mobileBiomarkerTitle__JfVZB",mobileBiomarkerHeaderLabel:"navigator_mobileBiomarkerHeaderLabel__qgerm",mobileBiomarkerMainTitle:"navigator_mobileBiomarkerMainTitle__JaI_P",mobileBiomarkerSubtitle:"navigator_mobileBiomarkerSubtitle__4YjRK",mobileBiomarkerHeaderIcon:"navigator_mobileBiomarkerHeaderIcon__CgkbQ",mobileBiomarkerHeaderBackIcon:"navigator_mobileBiomarkerHeaderBackIcon__qt9CY",mobileBiomarkerHeaderCloseIcon:"navigator_mobileBiomarkerHeaderCloseIcon___Yd3l",loading:"navigator_loading__QsfsJ",areaGlowOverlay:"navigator_areaGlowOverlay__5Kwdu",areaGlowPulse:"navigator_areaGlowPulse__Kxfm9"}},52950:e=>{e.exports={stack:"TabbedMobileTypeStack_stack__ZEWU6",typeButton:"TabbedMobileTypeStack_typeButton__Xp_4h",typeButtonSelected:"TabbedMobileTypeStack_typeButtonSelected__616zM"}},53152:(e,a,t)=>{"use strict";t.d(a,{A:()=>u});var l=t(37876),i=t(44113),n=t(79143),r=t(51882),o=t(97039);t(14232);var s=t(14043),d=t(85779),c=t(79256);function u(e){var a,t,u,v,m,p,_,b,g;let{sitenavs:h,children:f,preview:y=!1,previewData:x={},disable_ads:k=!1,header_type:N="default",navigator_header_title:w,navigator_header_link:T,navigator_header_logo:j,navigator_config:C,navigator_theme:B}=e,S=null==h?void 0:null===(a=h.site_settings)||void 0===a?void 0:a.website,A="BiomarkerNavigator"===N,P=A||"BIOMARKER"===N,M=A&&(null==B?void 0:B.pageBgColor)||"#1D1D1D",I=A&&B?{...B.tabColor&&{"--wp-tab-color":B.tabColor},...B.tabColorActive&&{"--wp-tab-color-active":B.tabColorActive},...B.tabColorHover&&{"--wp-tab-color-hover":B.tabColorHover},...B.tabColorActiveHover&&{"--wp-tab-color-active-hover":B.tabColorActiveHover},...B.pipelineBgColor&&{"--wp-tab-pipeline-color-active":B.pipelineBgColor},...B.secondBgTableColor&&{"--wp-second-bg-table":B.secondBgTableColor},...B.tableBodyBg&&{"--wp-table-body-bg":B.tableBodyBg},...B.tableBodySubtitle&&{"--wp-table-body-subtitle":B.tableBodySubtitle},...B.tableBodyTitle&&{"--wp-table-body-title":B.tableBodyTitle},...B.tableHeaderBg&&{"--wp-table-header-bg":B.tableHeaderBg},...B.tableTitle&&{"--wp-table-title":B.tableTitle}}:{},E=A?{margin:"0 auto",padding:"0",minHeight:"auto"}:P?{margin:"0 auto",marginTop:{xs:"-40px",md:"40px"},minHeight:"100vh"}:{margin:"30px auto",minHeight:"100vh"};return(0,l.jsxs)(c.J,{template:N,children:[(0,l.jsx)(s.A,{site_title:S,description:null==h?void 0:null===(t=h.seo_options)||void 0===t?void 0:t.description,title:null==h?void 0:null===(u=h.seo_options)||void 0===u?void 0:u.title,image:null==h?void 0:null===(v=h.seo_options)||void 0===v?void 0:v.image,dfp_zone:null==h?void 0:null===(m=h.seo_options)||void 0===m?void 0:m.dfp_zone,noindex:null==h?void 0:null===(p=h.seo_options)||void 0===p?void 0:p.noindex,nofollow:null==h?void 0:null===(_=h.seo_options)||void 0===_?void 0:_.nofollow,canonical_url:null==h?void 0:null===(b=h.seo_options)||void 0===b?void 0:b.canonical_url,site_url:null==h?void 0:null===(g=h.seo_options)||void 0===g?void 0:g.site_url,disable_ads:k}),(0,l.jsx)(r.A,{menu:h,preview:y,previewData:x,template:N,navigatorHeaderTitle:w,navigatorHeaderLink:T,navigatorHeaderLogo:j,navigatorConfig:C}),"AGA"===N&&(0,l.jsx)(d.A,{}),A?(0,l.jsx)(i.A,{style:{backgroundColor:M,...I},sx:{width:"100%",minHeight:"100vh",marginTop:{"@media (max-width: 727.95px)":"calc(96px + env(safe-area-inset-top, 0px) + 50px)","@media (min-width: 728px)":"0px"}},children:(0,l.jsx)(n.A,{maxWidth:"xl",sx:E,className:"layout-biomarker-navigator",children:(0,l.jsx)("main",{id:"main",children:f})})}):(0,l.jsx)(n.A,{maxWidth:"xl",sx:E,children:(0,l.jsx)("main",{id:"main",children:f})}),(0,l.jsx)(o.A,{menu:h})]})}},54288:e=>{e.exports={panel:"MigraineInsightStack_panel__uv1ch",stack:"MigraineInsightStack_stack__iVp34",panelSheet:"MigraineInsightStack_panelSheet___dXn1",promoCard:"MigraineInsightStack_promoCard__4cNIX"}},60054:e=>{e.exports={connector:"LabelConnector_connector__ckRD2",line:"LabelConnector_line__IsLXH",lineHovered:"LabelConnector_lineHovered__SxQJT",lineActive:"LabelConnector_lineActive__SWNxE"}},67246:e=>{e.exports={phase:"TabbedAreasPhase_phase__q1b3U",phaseName:"TabbedAreasPhase_phaseName__5Jyhk",areasList:"TabbedAreasPhase_areasList__Gp62h",area:"TabbedAreasPhase_area__BiLX0",areaTitle:"TabbedAreasPhase_areaTitle__rtSpa",empty:"TabbedAreasPhase_empty__o4cOd"}},75576:e=>{e.exports={tabsContainer:"MigraineTypeTabs_tabsContainer__3Snzb",tab:"MigraineTypeTabs_tab__NtTth",tabActive:"MigraineTypeTabs_tabActive__B89xx"}},80960:(e,a,t)=>{"use strict";t.r(a),t.d(a,{__N_SSG:()=>eQ,default:()=>e$});

1var l=t(37876),i=t(14232),n=t(18847),r=t.n(n),o=t(89099),s=t(6995),d=t(9227),c=t(53152),u=t(68608),v=t(4021),m=t(33565),p=t(8242),_=t.n(p);function b(e){let{open:a,onClose:t,cancerTypes:i,selectedCancerId:n,onSelectCancer:r}=e;if(!a)return null;let o=e=>{r(e),t()};return(0,l.jsxs)("div",{className:_().overlay,role:"dialog","aria-modal":"true","aria-label":"Select cancer type",children:[(0,l.jsxs)("div",{className:_().header,children:[(0,l.jsx)("h2",{className:_().title,children:"SELECT CANCER TYPE"}),(0,l.jsx)("button",{type:"button",className:_().closeButton,onClick:t,"aria-label":"Close cancer type menu",children:(0,l.jsx)("svg",{width:"20",height:"20",viewBox:"0 0 20 20",fill:"none",xmlns:"http://www.w3.org/2000/svg",children:(0,l.jsx)("path",{d:"M15 5L5 15M5 5L15 15",stroke:"currentColor",strokeWidth:"2",strokeLinecap:"round",strokeLinejoin:"round"})})})]}),(0,l.jsx)("div",{className:_().content,children:(0,l.jsx)("div",{className:_().buttonsList,children:i.map(e=>{let a=e.mobile_label||e.name,t=n===e.id;return(0,l.jsxs)("button",{type:"button",className:"".concat(_().cancerButton," ").concat(t?_().cancerButtonSelected:""),onClick:()=>o(e.id),children:[(0,l.jsx)("span",{className:_().cancerButtonText,children:a}),(0,l.jsx)("svg",{className:_().cancerButtonArrow,width:"20",height:"20",viewBox:"0 0 20 20",fill:"none",xmlns:"http://www.w3.org/2000/svg",children:(0,l.jsx)("path",{d:"M7.5 15L12.5 10L7.5 5",stroke:"currentColor",strokeWidth:"2",strokeLinecap:"round",strokeLinejoin:"round"})})]},e.id)})})})]})}var g=t(9462),h=t.n(g);let f=e=>{let{content:a}=e,t=null==a?void 0:a.trim();return t?(0,l.jsx)("div",{className:h().tagline,dangerouslySetInnerHTML:{__html:function(e){let a=e.replace(/<[^>]+>/g,"").length/2,t=0,l=!1,i=-1,n=1/0;for(let r=0;r<e.length;r++){let o=e[r];if("<"===o)l=!0;else if(">"===o)l=!1;else if(!l&&(t++,/\s/.test(o))){let e=Math.abs(t-a);e<n&&(n=e,i=r)}}return i<0?e:"".concat(e.slice(0,i),"<br />").concat(e.slice(i+1))}(function(e){if(/<(strong|b|em)\b/i.test(e))return e;let a=e.match(/^([\s\S]*?)([-–—])\s+([\s\S]+)$/);if(!a)return e;let[,t,l,i]=a;return"".concat(t).concat(l," <strong>").concat(i.trim(),"</strong>")}(t))}}):null};var y=t(3838),x=t.n(y);function k(e){let{id:a,title:t,position:i,isActive:n,isHovered:r,onClick:o,onMouseEnter:s,onMouseLeave:d,fillColor:c}=e;return(0,l.jsx)("button",{type:"button",className:"".concat(x().areaLabel," ").concat(n?x().areaLabelActive:""," ").concat(r?x().areaLabelHovered:""),style:{left:"".concat(i.x,"%"),top:"".concat(i.y,"%"),...n&&c?{borderColor:c,color:c}:{}},onClick:o,onMouseEnter:s,onMouseLeave:d,"aria-label":"Select ".concat(t),"data-area-id":a,children:(0,l.jsx)("span",{className:x().areaLabelText,children:t})})}var N=t(13588),w=t.n(N);function T(e){let{position:a,isActive:t,isHovered:i,fillColor:n="#00D5BE"}=e;return(0,l.jsx)("div",{className:"".concat(w().hotspot," ").concat(t?w().hotspotActive:""," ").concat(i?w().hotspotHovered:""),style:{left:"".concat(a.x,"%"),top:"".concat(a.y,"%"),...n?{backgroundColor:n,boxShadow:"0 0 20px ".concat(n)}:{}},"aria-hidden":"true"})}var j=t(60054),C=t.n(j);function B(e){let{from:a,to:t,isActive:i,isHovered:n,strokeColor:r="#00D5BE"}=e;return(0,l.jsx)("svg",{className:C().connector,style:{position:"absolute",top:0,left:0,width:"100%",height:"100%",pointerEvents:"none",overflow:"visible"},preserveAspectRatio:"none",children:(0,l.jsx)("line",{x1:"".concat(a.x,"%"),y1:"".concat(a.y,"%"),x2:"".concat(t.x,"%"),y2:"".concat(t.y,"%"),className:"".concat(C().line," ").concat(i?C().lineActive:""," ").concat(n?C().lineHovered:""),stroke:r,strokeWidth:i?"2":"1",strokeOpacity:i?"0.8":n?"0.6":"0.4",strokeDasharray:i?"0":"3,3"})})}var S=t(94497),A=t(19901),P=t(48723),M=t.n(P);function I(e){let a=e.replace(/<br\s*\/?>/gi,"\n").trim();if(!a)return[];let t=a.split(/\r?\n/).map(e=>e.replace(/<[^>]*>/g,"").trim()).filter(Boolean);if(1===t.length){let e=t[0];e.includes(";")?t=e.split(";").map(e=>e.trim()).filter(Boolean):e.includes(" | ")?t=e.split(" | ").map(e=>e.trim()).filter(Boolean):e.includes(",")&&(t=e.includes(", ")?e.split(", ").map(e=>

1e.trim()).filter(Boolean):e.split(",").map(e=>e.trim()).filter(Boolean))}return t}function E(e){return e?e.trim().toLowerCase().replace(/\+/g,"-").replace(/\s+/g,"-").replace(/[^a-z0-9-]+/g,"").replace(/-+/g,"-").replace(/^-+|-+$/g,""):""}function L(e){return e.trim().toLowerCase()}function R(e,a,t){if(!e)return t;if(e.startsWith("rgba("))return e.replace(/,\s*[\d.]+\)$/,", ".concat(a,")"));if(e.startsWith("rgb("))return e.replace("rgb(","rgba(").replace(")",", ".concat(a,")"));let l=e.replace("#",""),i=parseInt(l.slice(0,2),16),n=parseInt(l.slice(2,4),16),r=parseInt(l.slice(4,6),16);return"rgba(".concat(i,", ").concat(n,", ").concat(r,", ").concat(a,")")}function H(e){if(!(null==e?void 0:e.length))return"";let a=[];for(let t=0;t+1<e.length;t+=2)a.push("".concat(e[t],",").concat(e[t+1]));return a.join(" ")}function O(e,a,t){if(!(null==e?void 0:e.length)||e.length<6)return null;let l=0,i=0,n=0;for(let a=0;a+1<e.length;a+=2)l+=e[a],i+=e[a+1],n++;return 0===n?null:{x:l/n/a*100,y:i/n/t*100}}function D(e,a){var t,l,i;let n=(0,v.yv)(e.cards);return{id:a,name:null!==(l=null===(t=e.mainTitle)||void 0===t?void 0:t.toUpperCase())&&void 0!==l?l:"",mobile_label:e.mobile_label,side:"left",hotspots:[],lineItemId:e.line_item_id,biomarkers:(null!==(i=e.items)&&void 0!==i?i:[]).map((e,t)=>(function(e,a){var t,l,i,n,r,o,s,d,c,u,v,m,p,_,b,g;let h=I(null!==(p=null===(t=e.approved)||void 0===t?void 0:t.therapies)&&void 0!==p?p:""),f=I(null!==(_=null===(l=e.pipeline)||void 0===l?void 0:l.therapeutic)&&void 0!==_?_:""),y=!!((null===(n=e.approved)||void 0===n?void 0:null===(i=n.prevalence)||void 0===i?void 0:i.trim())||(null===(o=e.approved)||void 0===o?void 0:null===(r=o.tests)||void 0===r?void 0:r.trim())||h.length),x=!!((null===(d=e.pipeline)||void 0===d?void 0:null===(s=d.prevalence)||void 0===s?void 0:s.trim())||(null===(u=e.pipeline)||void 0===u?void 0:null===(c=u.tests)||void 0===c?void 0:c.trim())||f.length),k=null!==(b=null===(m=e.link)||void 0===m?void 0:null===(v=m.url)||void 0===v?void 0:v.trim())&&void 0!==b?b:"";return{id:a,name:null!==(g=e.title)&&void 0!==g?g:"",...k?{exploreHref:k}:{},...e.line_item_id?{lineItemId:e.line_item_id}:{},approved:y?{prevalence:e.approved.prevalence,tests:e.approved.tests,therapies:h}:void 0,pipeline:x?{prevalence:e.pipeline.prevalence,tests:e.pipeline.tests,therapies:f}:void 0}})(e,"".concat(a,"-item-").concat(t))),...n.length>0?{promoCards:n}:{}}}let W=r()(()=>t.e(2016).then(t.bind(t,2016)),{loadableGenerated:{webpack:()=>[null]},ssr:!1});function F(e){var a,t,n,r,v,p,_,g,h,y,x,N,w;let{postData:j,preview:C,previewData:P={}}=e,I=(0,o.useRouter)(),[F,V]=(0,i.useState)(P);(0,i.useEffect)(()=>{C&&fetch("/api/preview-status").then(e=>e.json()).then(e=>{e.preview&&e.previewData&&V(e.previewData)}).catch(()=>{})},[C]);let U=(0,i.useMemo)(()=>I.isReady?{tumor:"string"==typeof I.query.tumor?L(I.query.tumor):null,biomarker:"string"==typeof I.query.biomarker?E(I.query.biomarker):null,status:function(e){let a=Array.isArray(e)?e[0]:e;if("string"!=typeof a)return null;let t=a.trim().toLowerCase();return"approved"===t?"approved":"pipeline"===t?"pipeline":null}(I.query.status)}:null,[I.isReady,I.asPath]),z=(0,s.A)("(max-width: 767px)"),[q,G]=(0,i.useState)(!1);(0,i.useEffect)(()=>{G(!0)},[]);let[Y,J]=(0,i.useState)(null),[X,K]=(0,i.useState)(800),[Z,Q]=(0,i.useState)(null),[$,ee]=(0,i.useState)(""),[ea,et]=(0,i.useState)(null);(0,i.useEffect)(()=>{var e;let a=null==j?void 0:null===(e=j.mapped_image)||void 0===e?void 0:e.image_url;if(!a)return;let t=new window.Image;t.onload=()=>Q({width:t.naturalWidth,height:t.naturalHeight}),t.src=a},[null==j?void 0:null===(a=j.mapped_image)||void 0===a?void 0:a.image_url]),(0,i.useEffect)(()=>{var e;let a=null!==(e=ev.current)&&void 0!==e?e:em.current;a&&ee(getComputedStyle(a).getPropertyValue("--biomarker-color-teal-400").trim()||"rgba(0, 213, 190, 1)")},[]);let[el,ei]=(0,i.useState)({}),[en,er]=(0,i.useState)(!1),[eo,es]=(0,i.useState)(!1),[ed,ec]=(0,i.useState)("approved"),eu=(0,i.useRef)(null),ev=(0,i.useRef)(null),em=(0,i.useRef)(null),ep=(0,i.useRef)(null),e_=(0,i.useRef)(null);(0,i.useEffect)(()=>{ep.current=null,e_.current=null},[I.query.slug]);let eb=null==j?void 0:j.site_navs,eg={backgroundUrl:(0,u.ks)(null==j?void 0:j.biomarker_background_image),returnLogoUrl:null!==(y=(0,u.ks)(null==j?void 0:j.biomarker_return_image))&&void 0!==y?y:(0,u.ks)(null==j?void 0:j.biomarker_header_logo),returnLinkUrl:(null==j?void 0:null===(t=j.biomarker_return_link)||void 0===t?void 0:t.url)||"/",returnLinkTarget:null==j?void 0:null===(n=j.biomarker_return_link)||void 0===n?void 0:n.target,returnText:null==j?void 0:j.biomarker_return_text,subtitle:null==j?void 0:j.biomarker_subheading_text,titleColor:null==j?void 0:j.biomarker_heading_text_color,returnTextColor:null==j?void 0:j.biomarker_return_text_color,subtitleColor:null==j?void 0:j.biomarker_subheading_text_color,pageBgColor:null==j?void 0:j.page_bg_color,primaryMenuBg:null==j?void 0:j.primary_menu_bg,primaryMenuTextColor:null==j?void 0:j.primary_menu_text_color,primaryMenuHover:null==j?void 0:j.primary_menu_hover,primaryMenuActive:null==j?void 0:j.primary_menu_active},eh={pageBgColor:null==j?void 0:j.page_bg_color,tabColor:null==j?void 0:j.tab_color,tabColorActive:null==j?void 0:j.tab_color_active,tabColorHover:null==j?void 0:j.tab_color_hover,tabColorActiveHover:null==j?void 0:j.tab_color_active_hover,pipelineBgColor:null==j?void 0:j.pi

1peline_bg_color,secondBgTableColor:null==j?void 0:j.second_bg_table_color,tableBodyBg:null==j?void 0:j.table_body_bg,tableBodySubtitle:null==j?void 0:j.table_body_subtitle,tableBodyTitle:null==j?void 0:j.table_body_title,tableHeaderBg:null==j?void 0:j.table_header_bg,tableTitle:null==j?void 0:j.table_title},ef=!!((null==j?void 0:null===(r=j.mapped_image)||void 0===r?void 0:r.image_url)&&(null==j?void 0:null===(p=j.mapped_image)||void 0===p?void 0:null===(v=p.areas)||void 0===v?void 0:v.length)),ey=(0,i.useMemo)(()=>{var e,a;return(null!==(a=null==j?void 0:null===(e=j.mapped_image)||void 0===e?void 0:e.areas)&&void 0!==a?a:[]).map((e,a)=>({area:e,id:e.id||"area-".concat(a)}))},[null==j?void 0:null===(_=j.mapped_image)||void 0===_?void 0:_.areas]),ex=(0,i.useCallback)((e,a,t)=>{let l=ey.find(a=>a.id===e),i=l&&a?D(l.area,e).biomarkers.find(e=>e.id===a):null,n=new URLSearchParams;n.set("tumor",e),i&&n.set("biomarker",E(i.name)),n.set("status",t);let r=n.toString();window.history.replaceState(null,"","?".concat(r)),e_.current=r},[ey]),ek=(0,i.useCallback)(e=>{var a,t;let l=ey.findIndex(a=>a.id===e),i=ey[l].area.mainTitle,n=ey[l].area.line_item_id;null===(a=window.dataLayer)||void 0===a||a.push({event:"nav_engage",navigator_product:"biomarker",section_title:i,interaction_type:"click",line_item_id:n,post_id:j.ID}),J(e),es(!0);let r=ey.find(a=>a.id===e),o=null!==(t=null==r?void 0:r.area)&&void 0!==t?t:null;o&&D(o,e),ei({}),ex(e,null,ed)},[ey,j.ID,ex,ed]),eN=(0,i.useCallback)(function(){let e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];null!=Y&&ei(e=>({...e,[Y]:null})),es(!1),e&&er(!0)},[Y]);(0,i.useEffect)(()=>{if("undefined"!=typeof document&&(eo||en)){let e=document.documentElement,a=e.style.overflow,t=document.body.style.overflow;return e.style.overflow="hidden",document.body.style.overflow="hidden",()=>{e.style.overflow=a,document.body.style.overflow=t}}},[eo,en]),(0,i.useEffect)(()=>{z||(er(!1),es(!1),"undefined"==typeof document||(document.body.style.overflow=""))},[z]),(0,i.useEffect)(()=>{let e=()=>{window.innerWidth>=768&&eo&&(es(!1),document.documentElement.style.overflow="",document.body.style.overflow="")};return window.addEventListener("resize",e),()=>window.removeEventListener("resize",e)},[eo]);let ew=(0,i.useMemo)(()=>ey.length?{name:"navigator-map",areas:ey.map(e=>{let{area:a,id:t}=e,l=t===Y,i=t===ea&&!l;return{id:t,shape:a.shape,coords:a.coords,name:a.name,active:l,preFillColor:l?R(a.fillColor,.6,"rgba(0, 255, 227, 0.6)"):R(a.preFillColor,.3,"rgba(0, 213, 190, 0.3)"),fillColor:l?R(a.fillColor,.6,"rgba(0, 255, 227, 0.6)"):R(a.preFillColor,.3,"rgba(0, 213, 190, 0.3)"),strokeColor:l?R(a.fillColor,.8,"rgba(0, 255, 227, 0.8)"):i?R(a.fillColor,.6,"rgba(0, 255, 227, 0.6)"):R(a.strokeColor,.6,"rgba(255, 255, 255, 0.6)"),lineWidth:l||i?2:1,_data:a}})}:{name:"navigator-map",areas:[]},[ey,Y,ea]),eT=(0,i.useMemo)(()=>ey.map(e=>{let{area:a,id:t}=e;return D(a,t)}),[ey]),ej=null!==(x=ey.find(e=>{let{id:a}=e;return a===Y}))&&void 0!==x?x:null,eC=ej?D(ej.area,ej.id):null,eB=(w=null==ej?void 0:ej.area.fillColor)?w.startsWith("rgba(")?w.replace(/,\s*[\d.]+\)$/,", 1)"):w:"#00D5BE",eS=(0,i.useMemo)(()=>ey.map(e=>{let{area:a,id:t}=e;return{id:t,points:H(a.coords),fillColor:a.fillColor}}),[ey]),eA=ej?H(ej.area.coords):null;(0,i.useEffect)(()=>{(null==ey?void 0:ey.length)&&null!=Y&&(ey.some(e=>{let{id:a}=e;return a===Y})||J(null))},[ey,Y]),(0,i.useEffect)(()=>{var e,a,t;if(!I.isReady||!U||!(null==ey?void 0:ey.length))return;let l=I.asPath.includes("?")?I.asPath.slice(I.asPath.indexOf("?")+1):"",i=U.tumor,n=null!=i&&null!==(e=ey.find(e=>{let{id:a}=e;return L(a)===i}))&&void 0!==e?e:null;if(e_.current!==l){if(e_.current=l,n&&J(n.id),n){let{area:e,id:a}=n;if(U.biomarker){let t=D(e,a),l=U.biomarker,i=t.biomarkers.find(e=>E(e.name)===l);ei(e=>({...e,[a]:i?i.id:null}))}else ei(e=>({...e,[a]:null}))}U.status&&ec(U.status)}if(z&&n&&null!=i){let e="".concat(i,"|").concat(null!==(a=U.biomarker)&&void 0!==a?a:"","|").concat(null!==(t=U.status)&&void 0!==t?t:"");ep.current!==e&&(ep.current=e,es(!0),er(!1))}},[I.isReady,I.asPath,U,ey,z]);let eP=(e,a)=>{ei(t=>{let l=t[e]===a?null:a;return ex(e,l,ed),{...t,[e]:l}})},eM=(0,i.useCallback)(e=>{if(ec(e),null!=Y){var a;ex(Y,null!==(a=el[Y])&&void 0!==a?a:null,e)}},[Y,el,ex]),eI=e=>{var a;if(!e._data||z)return;let t=e.id||e._data.id,l=e._data.mainTitle||t,i=e._data.line_item_id;null===(a=window.dataLayer)||void 0===a||a.push({event:"nav_engage",navigator_product:"biomarker",section_title:l,interaction_type:"click",line_item_id:i,post_id:j.ID}),eu.current=t,ei({}),J(t),ex(t,null,ed)};(0,i.useLayoutEffect)(()=>{let e=eu.current;if(!e)return;eu.current=null;let a=document.getElementById("navigator-cancer-panel-".concat(e));null==a||a.scrollIntoView({behavior:"smooth",block:"nearest",inline:"nearest"})},[Y]);let eE=(0,i.useCallback)(()=>{requestAnimationFrame(()=>{let e=window.innerWidth>=768?ev.current:em.current;if(!e)return;let a=e.getBoundingClientRect().width;a>0&&K(Math.round(a))})},[]);return((0,i.useEffect)(()=>

1{if(!ef)return;let e=null,a=()=>{eE(),null!==e&&window.clearTimeout(e),e=window.setTimeout(()=>{e=null,eE()},150)};eE();let t=[ev.current,em.current].filter(e=>null!==e);if("undefined"!=typeof ResizeObserver&&t.length>0){let l=new ResizeObserver(()=>eE());return t.forEach(e=>l.observe(e)),window.addEventListener("resize",a),()=>{l.disconnect(),window.removeEventListener("resize",a),null!==e&&window.clearTimeout(e)}}return window.addEventListener("resize",a),()=>{window.removeEventListener("resize",a),null!==e&&window.clearTimeout(e)}},[ef,eE]),(0,i.useEffect)(()=>{ef&&eE()},[z,ef,eE]),(0,i.useEffect)(()=>{if(!q||!ey.length)return;let e=e=>{let a=e.querySelectorAll("area");return!!a.length&&(a.forEach((e,a)=>{let t=ey[a];t&&(t.area.line_item_id&&e.setAttribute("data-lineitem-id",t.area.line_item_id),t.area.mainTitle&&e.setAttribute("data-area-name",t.area.mainTitle))}),!0)},a=[];return[ev.current,em.current].forEach(t=>{if(t&&!e(t)){let l=new MutationObserver(()=>{e(t)&&l.disconnect()});l.observe(t,{childList:!0,subtree:!0}),a.push(l)}}),()=>a.forEach(e=>e.disconnect())},[q,ey]),null==j?void 0:j.mapped_image)?j.mapped_image.image_url&&(null===(g=j.mapped_image.areas)||void 0===g?void 0:g.length)?(0,l.jsx)(c.A,{sitenavs:eb,preview:C,previewData:F,header_type:"BiomarkerNavigator",navigator_header_title:null==j?void 0:j.post_title,navigator_header_link:null==j?void 0:j.biomarker_header_text_link,navigator_config:eg,navigator_theme:eh,children:(0,l.jsx)("div",{className:M().page,children:(0,l.jsxs)("div",{className:M().container,children:[(0,l.jsx)(f,{content:null==j?void 0:j.navigator_editor_content}),(0,l.jsxs)("div",{className:M().desktopLayout,children:[(0,l.jsxs)("div",{className:M().desktopContent,children:[(0,l.jsx)("div",{className:M().centerColumn,children:(0,l.jsxs)("div",{ref:ev,className:"".concat(M().imageWrapper," imageWrapper"),children:[ew.areas.length>0&&(0,l.jsx)(W,{src:j.mapped_image.image_url,name:"navigator-map",areas:ew.areas,onClick:eI,onMouseEnter:e=>et(e.id||null),onMouseLeave:()=>et(null),responsive:!0,parentWidth:X,natural:!0},z?"narrow":"wide"),Z&&(0,l.jsxs)("svg",{style:{position:"absolute",top:0,left:0,width:"100%",height:"100%",pointerEvents:"none",overflow:"visible"},viewBox:"0 0 ".concat(Z.width," ").concat(Z.height),children:[(0,l.jsxs)("defs",{children:[eS.filter(e=>{let{id:a}=e;return a!==Y&&a!==ea}).map(e=>{let{id:a,fillColor:t}=e;return(0,l.jsxs)("filter",{id:"shadow-idle-d-".concat(a),x:"-15%",y:"-15%",width:"130%",height:"130%",children:[(0,l.jsx)("feGaussianBlur",{in:"SourceAlpha",stdDeviation:"3.5",result:"blur"}),(0,l.jsx)("feOffset",{dx:"0",dy:"4",result:"off"}),(0,l.jsx)("feFlood",{floodColor:R(t,1,"#00D5BE"),floodOpacity:"0.25",result:"clr"}),(0,l.jsx)("feComposite",{in:"clr",in2:"off",operator:"in",result:"shadow"}),(0,l.jsx)("feMerge",{children:(0,l.jsx)("feMergeNode",{in:"shadow"})})]},a)}),eA&&(0,l.jsxs)("filter",{id:"shadow-active-d",x:"-30%",y:"-30%",width:"160%",height:"160%",children:[(0,l.jsx)("feGaussianBlur",{in:"SourceAlpha",stdDeviation:"5",result:"blur"}),(0,l.jsx)("feFlood",{floodColor:eB,floodOpacity:"1",result:"color"}),(0,l.jsx)("feComposite",{in:"color",in2:"blur",operator:"in",result:"glow"}),(0,l.jsx)("feMerge",{children:(0,l.jsx)("feMergeNode",{in:"glow"})})]})]}),eS.filter(e=>{let{id:a}=e;return a!==Y&&a!==ea}).map(e=>{let{id:a,points:t}=e;return(0,l.jsx)("polygon",{points:t,style:{fill:"black"},filter:"url(#shadow-idle-d-".concat(a,")")},a)}),eA&&(0,l.jsx)("polygon",{className:M().areaGlowOverlay,points:eA,style:{fill:"black"},filter:"url(#shadow-active-d)"})]}),Z&&(()=>{let e=ey.map((e,a)=>{let{area:t,id:l}=e,i=t.label_position||O(t.coords,Z.width,Z.height);if(!i)return null;let n=function(e,a,t){let l,i=arguments.length>3&&void 0!==arguments[3]?arguments[3]:0,n=arguments.length>4&&void 0!==arguments[4]?arguments[4]:1,r=arguments.length>5?arguments[5]:void 0;null!=r?l=r*Math.PI/180:(e.x,e.y,l=(e.y>55?e.x<50?.75*Math.PI:.4*Math.PI:e.y<35?e.x<50?Math.PI:0:e.x<35?Math.PI:e.x>65?0:e.x<50?.85*Math.PI:.15*Math.PI)+(i/Math.max(n,1)*Math.PI*.3-.15*Math.PI));let o=l;return{x:e.x+25*Math.cos(o),y:e.y+25*Math.sin(o),angle:180*o/Math.PI}}(i,Z.width,Z.height,a,ey.length,t.label_angle);return{id:l,centroid:i,position:n,title:t.mainTitle,area:t}}

1).filter(Boolean),a=function(e,a,t,l){let i=e.map(e=>({id:e.id,x:e.position.x,y:e.position.y,centroidX:e.centroid.x,centroidY:e.centroid.y,width:15,height:7}));for(let e=0;e<150;e++){let e=!1,a=0;for(let t=0;t<i.length;t++){for(let l=t+1;l<i.length;l++){let n=i[t],r=i[l];if(function(e,a){let t=arguments.length>2&&void 0!==arguments[2]?arguments[2]:3;return!(e.x+e.width+t<a.x||a.x+a.width+t<e.x||e.y+e.height+t<a.y||a.y+a.height+t<e.y)}(n,r,5)){e=!0;let t=n.x-r.x,l=n.y-r.y,i=Math.sqrt(t*t+l*l)||.1,o=(n.width+r.width)/2+(n.height+r.height)/2+5-i;if(o>0){let e=t/i*o*.5,s=l/i*o*.5;n.x+=3*e,n.y+=3*s,r.x-=3*e,r.y-=3*s,a+=Math.abs(e)+Math.abs(s)}}}let l=i[t],n=l.x-l.centroidX,r=l.y-l.centroidY,o=Math.sqrt(n*n+r*r);if(o<18){e=!0;let t=(18-o)/(o||.1),i=n*t*2.5,s=r*t*2.5;l.x+=i,l.y+=s,a+=Math.abs(i)+Math.abs(s)}let s=l.centroidX-l.x,d=l.centroidY-l.y;Math.sqrt(s*s+d*d)>40&&(l.x+=.05*s,l.y+=.05*d),l.x=Math.max(l.width/2+10,Math.min(100-l.width/2-10,l.x)),l.y=Math.max(l.height/2+10,Math.min(100-l.height/2-10,l.y))}if(!e&&a<.1)break}return i.map(e=>({id:e.id,position:{x:e.x,y:e.y}}))}(e,ey.map(e=>{let{area:a}=e;return{coords:a.coords}}),Z.width,Z.height);return e.map(e=>{let t=a.find(a=>a.id===e.id);return{...e,position:(null==t?void 0:t.position)||e.position}}).map(e=>{let{id:a,centroid:t,position:n,title:r,area:o}=e;return(0,l.jsxs)(i.Fragment,{children:[(0,l.jsx)(B,{from:t,to:n,isActive:a===Y,isHovered:a===ea,strokeColor:o.fillColor}),(0,l.jsx)(T,{position:t,isActive:a===Y,isHovered:a===ea,fillColor:o.fillColor}),(0,l.jsx)(k,{id:a,title:r,position:n,isActive:a===Y,isHovered:a===ea,onClick:()=>{if(!z){let e=ew.areas.find(e=>e.id===a);e&&eI(e)}},onMouseEnter:()=>et(a),onMouseLeave:()=>et(null),fillColor:o.fillColor})]},a)})})()]})}),eC&&(0,l.jsx)("div",{id:"navigator-cancer-panel-".concat(eC.id),className:M().cancerPanelScrollAnchor,children:(0,l.jsx)(m.A,{cancer:eC,expandedBiomarkerId:null!==(N=el[eC.id])&&void 0!==N?N:null,onBiomarkerToggle:e=>eP(eC.id,e),activeStatus:ed,onStatusChange:eM,postId:j.ID,areaId:eC.id,lineItemId:eC.lineItemId})})]}),(0,l.jsx)("aside",{className:M().adsSidebar,suppressHydrationWarning:!0,children:(null==j?void 0:null===(h=j.sidebar_settings)||void 0===h?void 0:h.length)?j.sidebar_settings.map((e,a)=>(0,l.jsx)("div",{suppressHydrationWarning:!0,children:(0,A.A)(e)},a)):(0,l.jsx)("div",{className:"ad",children:(0,l.jsxs)(d.A,{direction:"column",spacing:2,sx:{textAlign:"center"},children:[(0,l.jsx)(S.J5,{}),(0,l.jsx)(S.Jo,{})]})})})]}),(0,l.jsxs)("div",{className:M().mobileLayout,children:[(0,l.jsx)("div",{className:M().mobileSection,children:(0,l.jsxs)("div",{className:M().mobileBodyMapWrapper,children:[q&&z&&(0,l.jsxs)(l.Fragment,{children:[(0,l.jsxs)("div",{className:"".concat(M().hamburgerButtonWrapper," ").concat(en||eo?M().hamburgerButtonHidden:""),children:[(0,l.jsxs)("button",{type:"button",className:M().hamburgerButton,onClick:()=>er(!0),"aria-label":"Select cancer type",children:[(0,l.jsx)("span",{className:M().hamburgerButtonText,children:"CANCER TYPES"}),(0,l.jsx)("svg",{className:M().hamburgerIcon,width:"18",height:"18",viewBox:"0 0 18 18",fill:"none",xmlns:"http://www.w3.org/2000/svg","aria-hidden":"true",children:(0,l.jsx)("path",{d:"M4.5 6.75L9 11.25L13.5 6.75",stroke:"currentColor",strokeWidth:"2",strokeLinecap:"round",strokeLinejoin:"round"})})]}),(0,l.jsx)("div",{className:M().hamburgerTooltip,children:"Tap or click the organs to explore cancer types"})]}),(0,l.jsx)(b,{open:en,onClose:()=>er(!1),cancerTypes:eT,selectedCancerId:Y,onSelectCancer:ek})]}),(0,l.jsxs)("div",{ref:em,className:"".concat(M().imageWrapper," imageWrapper"),children:[ew.areas.length>0&&(0,l.jsx)(W,{src:j.mapped_image.image_url,name:"navigator-map-mobile",areas:ew.areas,onClick:e=>{e._data&&ek(e.id||e._data.id)},onMouseEnter:e=>et(e.id||null),onMouseLeave:()=>et(null),responsive:!0,parentWidth:X,natural:!0},z?"narrow":"wide"),Z&&(0,l.jsxs)("svg",{style:{position:"absolute",top:0,left:0,width:"100%",height:"100%",pointerEvents:"none",overflow:"visible"},viewBox:"0 0 ".concat(Z.width," ").concat(Z.height),children:[(0,l.jsxs)("defs",{children:[eS.filter(e=>{let{id:a}=e;return a!==Y&&a!==ea}).map(e=>{let{id:a,fillColor:t}=e;return(0,l.jsxs)("filter",{id:"shadow-idle-m-".concat(a),x:"-15%",y:"-15%",width:"130%",height:"130%",children:[(0,l.jsx)("feGaussianBlur",{in:"SourceAlpha",stdDeviation:"3.5",result:"blur"}),(0,l.jsx)("feOffset",{dx:"0",dy:"4",result:"off"}),(0,l.jsx)("feFlood",{floodColor:R(t,1,"#00D5BE"),floodOpacity:"0.25",result:"clr"}),(0,l.jsx)("feComposite",{in:"clr",in2:"off",operator:"in",result:"shadow"}),(0,l.jsx)("feMerge",{children:(0,l.jsx)("feMergeNode",{in:"shadow"})})]},a)}),eA&&(0,l.jsxs)("filter",{id:"shadow-active-m",x:"-30%",y:"-30%",width:"160%",height:"160%",children:[(0,l.jsx)("feGaussianBlur",{in:"SourceAlpha",stdDeviation:"5",result:"blur"}),(0,l.jsx)("feFlood",{floodColor:eB,floodOpacity:"1",result:"color"}),(0,l.jsx)("feComposite",{in:"color",in2:"blur",operator:"in",result:"glow"}),(0,l.jsx)("feMerge",{children:(0,l.jsx)("feMergeNode",{in:"glow"})})]})]}),eS.filter(e=>{let{id:a}=e;return a!==Y&&a!==ea}).map(e=>{let{id:a,points:t}=e;return(0,l.jsx)("polygon",{points:t,style:{fill:"black"}

1,filter:"url(#shadow-idle-m-".concat(a,")")},a)}),eA&&(0,l.jsx)("polygon",{className:M().areaGlowOverlay,points:eA,style:{fill:"black"},filter:"url(#shadow-active-m)"})]}),Z&&ey.map(e=>{let{area:a,id:t}=e,i=a.label_position||O(a.coords,Z.width,Z.height);return i?(0,l.jsx)(T,{position:i,isActive:t===Y,isHovered:t===ea,fillColor:a.fillColor},t):null})]})]})}),q&&z&&eo&&eC&&(0,l.jsxs)("div",{className:M().mobileBiomarkerOverlay,role:"dialog","aria-modal":"true","aria-labelledby":"mobile-navigator-area-title",children:[(0,l.jsxs)("div",{className:M().mobileBiomarkerHeader,children:[(0,l.jsxs)("div",{className:M().mobileBiomarkerTitle,children:[(0,l.jsx)("span",{className:M().mobileBiomarkerHeaderLabel,children:"SELECTED TUMOR TYPE"}),(0,l.jsx)("h2",{id:"mobile-navigator-area-title",className:M().mobileBiomarkerMainTitle,children:eC.name}),(0,l.jsxs)("span",{className:M().mobileBiomarkerSubtitle,children:[eC.biomarkers.length," BIOMARKER",1!==eC.biomarkers.length?"S":""]})]}),(0,l.jsx)("button",{type:"button",className:M().mobileBiomarkerHeaderIcon,onClick:()=>eN(!1),"aria-label":"Close panel",children:(0,l.jsx)("svg",{width:"20",height:"20",viewBox:"0 0 20 20",fill:"none",xmlns:"http://www.w3.org/2000/svg",children:(0,l.jsx)("path",{d:"M15 5L5 15M5 5L15 15",stroke:"currentColor",strokeWidth:"2",strokeLinecap:"round",strokeLinejoin:"round"})})})]}),(0,l.jsx)("div",{className:M().mobileBiomarkerScrollArea,children:(0,l.jsx)(m.A,{cancer:eC,expandedBiomarkerId:el[eC.id]||null,onBiomarkerToggle:e=>eP(eC.id,e),hideTitle:!0,mobileListStyle:!0,variant:"mobileOverlay",activeStatus:ed,onStatusChange:eM,postId:j.ID,areaId:eC.id,lineItemId:eC.lineItemId})})]})]})]})})}):(0,l.jsx)(c.A,{sitenavs:eb,preview:C,previewData:F,header_type:"BiomarkerNavigator",navigator_header_title:null==j?void 0:j.post_title,navigator_header_link:null==j?void 0:j.biomarker_header_text_link,navigator_config:eg,navigator_theme:eh,children:(0,l.jsx)("div",{className:M().loading,children:"Mapped image URL or areas data is missing"})}):(0,l.jsx)(c.A,{sitenavs:eb,preview:C,previewData:F,header_type:"BiomarkerNavigator",navigator_header_title:null==j?void 0:j.post_title,navigator_header_link:null==j?void 0:j.biomarker_header_text_link,navigator_config:eg,navigator_theme:eh,children:(0,l.jsx)("div",{className:M().loading,children:"No mapped_image data available"})})}function V(e){if(null==e)return[];if(Array.isArray(e))return e.map(e=>String(e).trim()).filter(Boolean);let a=String(e).trim();return a?a.replace(/<br\s*\/?>/gi,"\n").split(/\r?\n/).map(e=>e.replace(/<[^>]*>/g,"").trim()).filter(Boolean):[]}function U(e){for(var a=arguments.length,t=Array(a>1?a-1:0),l=1;l<a;l++)t[l-1]=arguments[l];for(let a of t){let t=e[a];if(null==t)continue;let l=String(t).trim();if(l)return l}return""}function z(e){let a=e.differential_diagnosis;return null==a?[]:Array.isArray(a)?a:[]}function q(e,a,t,l){let i=l?{viewMoreText:"View more",viewMoreHref:l}:{},n=z(e),r=[];for(let e of n){if(!e||"object"!=typeof e)continue;let a=function(e){let a=[],t=U(e,"title");t&&a.push({label:t,items:[]});let l=U(e,"migraine_features","migraineFeatures"),i=U(e,"key_point","keyPoint");return l&&a.push({label:"MIGRAINE FEATURES",items:[l]}),i&&a.push({label:"KEY POINT",items:[i]}),a}(e);0!==a.length&&r.push({segId:"dd-".concat(r.length),label:function(e,a){let t=U(e,"tab_name","tabName");return t||"Comparison ".concat(a+1)}(e,r.length),blocks:a})}return 0===r.length?{id:a,title:"DIFFERENTIAL DIAGNOSIS",contentByPhase:{approved:[]},...i}:{id:a,title:"DIFFERENTIAL DIAGNOSIS",contentByPhase:{},...i,segmentTabs:r.map(e=>({id:e.segId,label:e.label})),segmentContent:Object.fromEntries(r.map(e=>[e.segId,e.blocks]))}}function G(e){var a,t,l;if(!e)return[];let i=[];return(null===(a=e.presentation)||void 0===a?void 0:a.trim())&&i.push({label:"PRESENTATION",items:[e.presentation]}),(null===(t=e.prevalence)||void 0===t?void 0:t.trim())&&i.push({label:"PREVALENCE",items:[e.prevalence]}),(null===(l=e.timing)||void 0===l?void 0:l.trim())&&i.push({label:"TIMING",items:[e.timing]}),i}function Y(e){var a,t,l;if(!e)return[];let i=[];return(null===(a=e.first_line)||void 0===a?void 0:a.trim())&&i.push({label:"FIRST LINE",items:[e.first_line]}),(null===(t=e.dosage)||void 0===t?void 0:t.trim())&&i.push({label:"MEDICATION & DOSAGE",

1items:[e.dosage]}),(null===(l=e.efficacy)||void 0===l?void 0:l.trim())&&i.push({label:"EFFICACY",items:[e.efficacy]}),i}function J(e){var a,t,l;return!!((null==e?void 0:null===(a=e.presentation)||void 0===a?void 0:a.trim())||(null==e?void 0:null===(t=e.prevalence)||void 0===t?void 0:t.trim())||(null==e?void 0:null===(l=e.timing)||void 0===l?void 0:l.trim()))}function X(e){var a,t,l;return!!((null==e?void 0:null===(a=e.first_line)||void 0===a?void 0:a.trim())||(null==e?void 0:null===(t=e.dosage)||void 0===t?void 0:t.trim())||(null==e?void 0:null===(l=e.efficacy)||void 0===l?void 0:l.trim()))}function K(e,a,t,l){var i,n,r,o;let s=e.symptoms?G(e.symptoms.visual):(null===(n=e.approved)||void 0===n?void 0:null===(i=n.prevalence)||void 0===i?void 0:i.trim())?[{label:"PREVALENCE",items:[e.approved.prevalence]}]:[],d=e.symptoms?G(e.symptoms.sensory):(null===(o=e.pipeline)||void 0===o?void 0:null===(r=o.prevalence)||void 0===r?void 0:r.trim())?[{label:"PREVALENCE",items:[e.pipeline.prevalence]}]:[];return{id:a,title:t,contentByPhase:{},...l?{viewMoreText:"View more",viewMoreHref:l}:{},segmentTabs:[{id:"visual",label:"VISUAL"},{id:"sensory",label:"SENSORY"},{id:"speech",label:"SPEECH"}],segmentContent:{visual:s,sensory:d,speech:e.symptoms?G(e.symptoms.speech):[]}}}function Z(e,a,t,l){var i,n,r,o;let s=e.treatment?Y(e.treatment.severe):e.approved?[...(null===(i=e.approved.prevalence)||void 0===i?void 0:i.trim())?[{label:"PREVALENCE",items:[e.approved.prevalence]}]:[],...(null===(n=e.approved.therapies)||void 0===n?void 0:n.trim())?[{label:"THERAPIES",items:[e.approved.therapies]}]:[]]:[],d=e.treatment?Y(e.treatment.mild):e.pipeline?[...(null===(r=e.pipeline.prevalence)||void 0===r?void 0:r.trim())?[{label:"PREVALENCE",items:[e.pipeline.prevalence]}]:[],...(null===(o=e.pipeline.therapeutic)||void 0===o?void 0:o.trim())?[{label:"THERAPEUTIC",items:[e.pipeline.therapeutic]}]:[]]:[];return{id:a,title:t,contentByPhase:{},...l?{viewMoreText:"View more",viewMoreHref:l}:{},segmentTabs:[{id:"severe",label:"SEVERE"},{id:"mild",label:"MILD"}],segmentContent:{severe:s,mild:d}}}function Q(e,a,t,l){var i,n,r;let o=e.prevention,s=[];return(null===(i=o.first_line_therapy)||void 0===i?void 0:i.trim())&&s.push({label:"FIRST LINE THERAPY",items:[o.first_line_therapy]}),(null===(n=o.dosage)||void 0===n?void 0:n.trim())&&s.push({label:"MEDICATION & DOSAGE",

1items:o.dosage.split(/\r?\n/).filter(Boolean)}),(null===(r=o.target_population)||void 0===r?void 0:r.trim())&&s.push({label:"TARGET POPULATION",items:o.target_population.split(/\r?\n/).filter(Boolean)}),{id:a,title:t,contentByPhase:{approved:s},...l?{viewMoreText:"View more",viewMoreHref:l}:{}}}function $(e,a,t){var l,i,n;let r=null!==(n=null===(i=e.link)||void 0===i?void 0:null===(l=i.url)||void 0===l?void 0:l.trim())&&void 0!==n?n:"",o=function(e){if(e.symptoms)return J(e.symptoms.visual)||J(e.symptoms.sensory)||J(e.symptoms.speech);let a=e.title.toLowerCase();if(/symptom/.test(a)){var t,l,i,n;return!!((null===(l=e.approved)||void 0===l?void 0:null===(t=l.prevalence)||void 0===t?void 0:t.trim())||(null===(n=e.pipeline)||void 0===n?void 0:null===(i=n.prevalence)||void 0===i?void 0:i.trim()))}return!1}(e),s=function(e){let a=z(e);return 0!==a.length&&a.some(e=>!!(U(e,"title")||U(e,"tab_name","tabName")||U(e,"migraine_features","migraineFeatures")||U(e,"key_point","keyPoint")))}(e),d=function(e){if(e.treatment)return X(e.treatment.severe)||X(e.treatment.mild);let a=e.title.toLowerCase();if(/treat/.test(a)){var t,l,i,n,r,o,s,d;return!!((null===(l=e.approved)||void 0===l?void 0:null===(t=l.prevalence)||void 0===t?void 0:t.trim())||(null===(n=e.approved)||void 0===n?void 0:null===(i=n.therapies)||void 0===i?void 0:i.trim())||(null===(o=e.pipeline)||void 0===o?void 0:null===(r=o.prevalence)||void 0===r?void 0:r.trim())||(null===(d=e.pipeline)||void 0===d?void 0:null===(s=d.therapeutic)||void 0===s?void 0:s.trim()))}return!1}(e),c=function(e){var a,t,l;let i=e.prevention;return!!i&&!!((null===(a=i.first_line_therapy)||void 0===a?void 0:a.trim())||(null===(t=i.dosage)||void 0===t?void 0:t.trim())||(null===(l=i.target_population)||void 0===l?void 0:l.trim()))}(e),u=+!!o+ +!!s+ +!!d+ +!!c,v=(null==t?void 0:t.fixedSectionTitles)===!0;if(0===u){let{viewMoreText:t,viewMoreHref:l}=function(e){var a,t,l;let i=null!==(l=null===(t=e.link)||void 0===t?void 0:null===(a=t.url)||void 0===a?void 0:a.trim())&&void 0!==l?l:"";return i?{viewMoreText:"View more",viewMoreHref:i}:{viewMoreText:void 0,viewMoreHref:void 0}}(e);return[{id:a,title:e.title,contentByPhase:{},...t?{viewMoreText:t,viewMoreHref:l}:{}}]}if(1===u){let t=v?o?"SYMPTOMS":s?"DIFFERENTIAL DIAGNOSIS":d?"TREATMENT":"PREVENTION":e.title,l=v?o?"".concat(a,"-symptoms"):s?"".concat(a,"-differential"):d?"".concat(a,"-treatment"):"".concat(a,"-prevention"):a;return o?[K(e,l,t,r)]:s?[q(e,l,t,r)]:d?[Z(e,l,t,r)]:[Q(e,l,t,r)]}let m=[];return o&&m.push(K(e,"".concat(a,"-symptoms"),"SYMPTOMS",r)),s&&m.push(q(e,"".concat(a,"-differential"),"DIFFERENTIAL DIAGNOSIS",r)),d&&m.push(Z(e,"".concat(a,"-treatment"),"TREATMENT",r)),c&&m.push(Q(e,"".concat(a,"-prevention"),"PREVENTION",r)),m}var ee=t(89134),ea=t.n(ee),et=t(21575),el=t(30822);let ei={PRESENTATION:"/icons/presentation_icon.svg",PREVALENCE:"/icons/prevalence_icon.svg",TIMING:"/icons/Timing.svg","FIRST LINE":"/icons/treatment_icon.svg"};function en(e){return e.flatMap(e=>{let a;return String(e).replace(/<br\s*\/?>/gi,"\n").replace(/\)\s*n(?=[A-Z])/g,")\n").replace(/\s+n(?=[A-Z])/g,"\n").replace(/([a-z0-9])n(?=[A-Z])/g,"$1\n").split(/\r?\n/).map(e=>e.trim()).filter(e=>e.length>0)})}function er(e,a){let t=e.contentByPhase[a];return null!=t&&(Array.isArray(t)?t.some(e=>e.html&&e.html.trim()||e.items&&e.items.some(e=>String(e).trim())):Object.values(t).some(e=>e.some(e=>e.html&&e.html.trim()||e.items&&e.items.some(e=>String(e).trim()))))}let eo=function(e){var a,t,n,r;let{panel:o,className:s,defaultExpanded:d=!0,appearance:c="default",hideContentLabelIcons:u=!1,expanded:v,onExpandedChange:m,onExpand:p,onInnerTabChange:_}=e,b=void 0!==v,[g,h]=(0,i.useState)(d),f=b?v:g,y="tabbed"===c,x=e=>{A(e.id),null==_||_(o.title,e.label)},k=(null!==(t=null===(a=o.segmentTabs)||void 0===a?void 0:a.length)&&void 0!==t?t:0)>0,N=null!==(n=o.segmentTabs)&&void 0!==n?n:[],w=(0,i.useMemo)(()=>er(o,"approved")?"approved":er(o,"pipeline")?"pipeline":"approved",[o]),T=(0,i.useMemo)(()=>{var e;return null!==(e=o.contentByPhase[w])&&void 0!==e?e:[]},[o,w]),j=(0,i.useMemo)(()=>{var e,a;return null!==(a=null===(e=o.tabsByPhase)||void 0===e?void 0:e[w])&&void 0!==a?a:[]},[o,w]),C=k?N:j,B=C.length>0?C[0].id:null,[S,A]=(0,i.useState)(B);(0,i.useEffect)(()=>{A(B)},[o.id,k,B,w]);let P=C.length>0&&S?S:B,M=(0,i.useMemo)(()=>{var e,a,t;return k&&P?null!==(a=null===(e=o.segmentContent)||void 0===e?void 0:e[P])&&void 0!==a?a:[]:!k&&j.length>0&&P?Array.isArray(T)?[]:null!==(t=T[P])&&void 0!==t?t:[]:!k&&Array.isArray(T)?T:[]},[k,o.segmentContent,P,j.length,T]),I="biomarker-panel-content-".concat(o.id),E=C.length>0;return(0,l.jsxs)("div",{className:[ea().panel,y?ea().panelTabbed:null,s].filter(

1Boolean).join(" "),children:[(0,l.jsxs)("button",{type:"button",className:ea().accordionButton,onClick:()=>{let e=!f;if(b?null==m||m(e):h(e),e){var a,t;let e=null!==(a=C.find(e=>e.id===P))&&void 0!==a?a:null;null==p||p(o.title,null!==(t=null==e?void 0:e.label)&&void 0!==t?t:null)}},"aria-expanded":f,"aria-controls":I,id:"biomarker-panel-heading-".concat(o.id),children:[(0,l.jsx)("span",{className:ea().title,children:o.title}),f?(0,l.jsx)(et.A,{className:ea().chevron,"aria-hidden":!0}):(0,l.jsx)(el.A,{className:ea().chevron,"aria-hidden":!0})]}),(0,l.jsx)("div",{className:ea().contentSlideWrapper,"data-expanded":f,"aria-hidden":!f,children:(0,l.jsxs)("div",{id:I,className:ea().accordionContent,role:"region","aria-labelledby":"biomarker-panel-heading-".concat(o.id),children:[o.defaultContent&&o.defaultContent.length>0&&(0,l.jsx)("div",{className:ea().contentContainer,children:o.defaultContent.map((e,a)=>{let t=!u&&ei[e.label]?ei[e.label]:void 0,i=!!e.html;return(0,l.jsxs)("div",{className:null!=t?"".concat(ea().contentBlock," ").concat(ea().contentBlockWithIcon):ea().contentBlock,children:[e.label&&(0,l.jsxs)("div",{className:ea().contentLabel,children:[null!=t?(0,l.jsx)("img",{src:t,alt:"",className:ea().contentLabelIcon,"aria-hidden":!0}):null,(0,l.jsx)("span",{children:e.label})]}),i?(0,l.jsx)("div",{className:ea().htmlContent,dangerouslySetInnerHTML:{__html:e.html}}):(0,l.jsx)("ul",{className:ea().contentItems,children:en(e.items||[]).map((t,i)=>(0,l.jsx)("li",{children:t},"default-".concat(e.label,"-").concat(a,"-").concat(i)))})]},"default-".concat(e.label,"-").concat(a))})}),E?y?(0,l.jsx)("div",{className:ea().tabsRowScroll,style:{"--tab-count":Math.min(C.length,3)},children:(0,l.jsx)("div",{className:ea().tabsRow,role:"tablist","aria-label":"".concat(o.title," tabs"),children:C.map(e=>(0,l.jsx)("button",{type:"button",role:"tab","aria-selected":P===e.id,className:P===e.id?"".concat(ea().innerTab," ").concat(ea().innerTabActive):ea().innerTab,onClick:()=>x(e),children:e.label},e.id))})}):(0,l.jsx)("div",{className:ea().tabsRow,role:"tablist","aria-label":"".concat(o.title," tabs"),children:C.map(e=>(0,l.jsx)("button",{type:"button",role:"tab","aria-selected":P===e.id,className:P===e.id?"".concat(ea().innerTab," ").concat(ea().innerTabActive):ea().innerTab,onClick:()=>A(e.id),children:e.label},e.id))}):null,(0,l.jsxs)("div",{className:ea().contentContainer,children:[0===M.length?(0,l.jsx)("p",{className:ea().noData,children:"No data available"}):M.map((e,a)=>{let t=!u&&ei[e.label]?ei[e.label]:void 0,i=!!e.html;return(0,l.jsxs)("div",{className:null!=t?"".concat(ea().contentBlock," ").concat(ea().contentBlockWithIcon):ea().contentBlock,children:[e.label&&(0,l.jsxs)("div",{className:ea().contentLabel,children:[null!=t?(0,l.jsx)("img",{src:t,alt:"",className:ea().contentLabelIcon,"aria-hidden":!0}):null,(0,l.jsx)("span",{children:e.label})]}),i?(0,l.jsx)("div",{className:ea().htmlContent,dangerouslySetInnerHTML:{__html:e.html}}):(0,l.jsx)("ul",{className:ea().contentItems,children:en(e.items||[]).map((t,i)=>(0,l.jsx)("li",{children:t},"".concat(e.label,"-").concat(a,"-").concat(i)))})]},"".concat(e.label,"-").concat(a))}),o.viewMoreText?(0,l.jsx)("a",{href:null!==(r=o.viewMoreHref)&&void 0!==r?r:"#",className:ea().viewMore,"aria-label":"View more ".concat(o.title),children:o.viewMoreText}):null]})]})})]})};var es=t(87005),ed=t(54288),ec=t.n(ed);function eu(e){let{panels:a,className:t,defaultExpanded:n=!0,appearance:r="default",hideContentLabelIcons:o,layout:s="default",openPanelId:d,onOpenPanelChange:c,onPanelExpand:u,onInnerTabChange:m,promoCards:p}=e,_="tabbed"===r,b=(0,i.useMemo)(()=>a.map(e=>e.id).join("|"),[a]),g=void 0!==d,[h,f]=(0,i.useState)(()=>_&&n&&a[0]?a[0].id:null),y=g?d:h,x=g?e=>null==c?void 0:c(e):f;if((0,i.useEffect)(()=>{_&&!g&&f(n&&a.length>0?a[0].id:null)},[_,n,b,g]),0===a.length)return null;let k=[ec().panel,"sheet"===s?ec().panelSheet:null,t].filter(Boolean).join(" "),N=null!=o?o:"tabbed"===r;return(0,l.jsx)("div",{className:k,children:(0,l.jsx)("div",{className:ec().stack,children:(0,v.mV)(a,null!=p?p:[],e=>(0,l.jsx)(eo,{panel:e,defaultExpanded:n,appearance:r,hideContentLabelIcons:N,onExpand:u,onInnerTabChange:m,..._?{expanded:y===e.id,onExpandedChange:a=>{x(a?e.id:null)}}:{}},e.id),(e,a)=>(0,l.jsx)(es.A,{card:e,className:ec().promoCard},"promo-".concat(a)))})})}var ev=t(75576),em=t.n(ev);let ep=function(e){let{tabs:a,activeTypeId:t,onTypeChange:i,ariaLabel:n="Navigator regions",className:r}=e;return(0,l.jsx)("div",{className:"".concat(em().tabsContainer," ").concat(null!=r?r:"").trim(),role:"tablist","aria-label":n,children:a.map(e=>(0,l.jsx)("button",{type:"button",role:"tab","aria-selected":t===e.id,"aria-controls":"migraine-nav-panel-".concat(e.id),id:"migraine-nav-tab-".concat(e.id),className:t===e.id?"".concat(em().tab," ").concat(em().tabActive):em().tab,onClick:()=>i(e.id),children:e.label},e.id))})};var e_=t(89478),eb=t.n(e_);let eg=function(e){var a,t;let{phases:n,activeIndex:r=0,onPhaseClick:o,className:s,appearance:d="default",showProgressFill:c=!0,hideActiveIndicator:u=!1}=e,v="tabbed"===d,m=!v&&c,p=!!v||u,_=0===n.length?-1:r<0?-1:Math.min(Math.max(0,r),n.length-1),b=_>=0?n[_]:void 0,g=b?(null!==(t=null!==(a=b.description)&&void 0!==a?a:b.callout)&&void 0!==t?t:"").trim():"",h=(0,i.useRef)(null),[f,y]=(0,i.useState)(null),[x,k]=(0,i.useState)(null),[N,w]=(0,i.useState)(null),T=(0,i.useCallback)(()=>{let e=h.current;if(!e)return;let a=e.querySelector(".".concat(eb().timelineBarInner)),t=e.querySelector('button[data-phase-index="'.concat(_,'"]'));if(a&&t){let l=a.getBoundingClientRect(),i=t.getBoundingClientRect();if(p?k(null):k({left:i.left-l.left,width:i.width}),m&&l.width>0?w(Math.min(100,Math.max(0,(i.left-l.left+i.width/2)/l.width*100))):w(null),g&&!v){let a=e.getBoundingClientRect();y(i.left-a.left+i.width/2)}else y(null)}else k(null),w(null),y(null)},[_,g,m,p,v]);return((0,i.useLayoutEffect)(()=>{T(),window.addEventListener("resize",T);let e=h.current;if(!e){window.removeEventListener("resize",T);return}let a=new ResizeObserver(T);return a.observe(e),()=>{a.disconnect(),window.removeEventListener("resize",T)}},[T,n]),n.length)?(0,l.jsxs)("div",{ref:h,className:"".concat(eb().root).concat(v?" ".concat(eb().rootTabbed):""," ").concat(null!=s?s:"").trim(),"aria-label":"Migraine phase timeline",children:[(0,l.jsx)("div",{className:eb().timelineBar,role:"tablist","aria-label":"Migraine phases",children:(0,l.jsxs)("div",{className:eb().timelineBarInner,children:[m&&null!=N&&(0,l.jsx)("div",{className:eb().lineFill,style:{width:"".concat(N,"%")},"aria-hidden":!0}),!p&&null!=x&&(0,l.jsx)("div",{className:eb().activeIndicator,style:{left:x.left,width:x.width},"aria-hidden":!0}),n.map((e,a)=>{let t=a===_,i=e.name&&e.name.trim()||e.label,n="".concat(a+1," ").concat(i).trim();return(0,l.jsx)("button",{type:"button",role:"tab","data-phase-index":a,"aria-selected":t,className:t?"".concat(eb().phaseButton," ").concat(eb().phaseButtonActive):eb().phaseButton,onClick:()=>null==o?void 0:o(a),children:v?(0,l.jsxs)(l.Fragment,{children:[(0,l.jsx)("span",{className:eb().tabbedSegmentBar,"aria-hidden":!0}),(0,l.jsx)("span",{className:eb().tabbedSegmentLabel,children:n}

1),(0,l.jsxs)("span",{className:eb().phaseNumber,children:[e.label,e.name?": ":""]}),e.name?(0,l.jsx)("span",{className:eb().phaseTitle,children:e.name}):null,e.duration?(0,l.jsx)("span",{className:eb().phaseMeta,children:e.duration}):null]}):(0,l.jsxs)(l.Fragment,{children:[(0,l.jsxs)("span",{className:eb().phaseNumber,children:[e.label,e.name?": ":""]}),e.name?(0,l.jsx)("span",{className:eb().phaseTitle,children:e.name}):null,e.duration?(0,l.jsx)("span",{className:eb().phaseMeta,children:e.duration}):null]})},"".concat(e.label,"-").concat(e.name,"-").concat(a))})]})}),!v&&g?(0,l.jsx)("p",{className:eb().phaseDescription,role:"status",style:null!=f?{left:f,transform:"translateX(-50%)"}:void 0,children:g}):null]}):null};function eh(e){let{open:a,onClose:t,options:i,selectedId:n,onSelectType:r}=e;if(!a)return null;let o=e=>{r(e),t()};return(0,l.jsxs)("div",{className:_().overlay,role:"dialog","aria-modal":"true","aria-label":"Select migraine type",children:[(0,l.jsx)("button",{type:"button",className:_().closeButton,onClick:t,"aria-label":"Close menu",children:(0,l.jsx)("img",{src:"/icons/biomarker_close_icon.svg",alt:"",width:32,height:32,"aria-hidden":!0,style:{display:"block",width:20,height:20,objectFit:"contain"}})}),(0,l.jsx)("div",{className:_().content,children:(0,l.jsx)("div",{className:_().buttonsList,children:i.map(e=>{let a=n===e.id;return(0,l.jsx)("button",{type:"button",className:"".concat(_().cancerButton," ").concat(a?_().cancerButtonSelected:""),onClick:()=>o(e.id),children:e.label},e.id)})})})]})}var ef=t(33170),ey=t.n(ef);let ex="Migraine Journey Navigator",ek=r()(()=>t.e(2016).then(t.bind(t,2016)),{loadableGenerated:{webpack:()=>[null]},ssr:!1});function eN(e,a){var t;return(null==e?void 0:null===(t=e.id)||void 0===t?void 0:t.trim())||"migraine-area-".concat(a)}function ew(e){return(null==e?void 0:e.length)?e.map((e,a)=>{var t,l,i,n,r;return{id:eN(e,String(a)),phaseLabel:(null===(t=e.name)||void 0===t?void 0:t.trim())||"Phase ".concat(a+1),label:(null!==(r=null!==(n=e.mainTitle)&&void 0!==n?n:e.name)&&void 0!==r?r:"").trim()||"Region ".concat(a+1),callout:(null===(i=e.phases)||void 0===i?void 0:null===(l=i[0])||void 0===l?void 0:l.callout)||void 0}}):[]}function eT(e){let{variant:a,imageUrl:t,mapperData:i,imageWidth:n,naturalImageSize:r,activeAreaPolygonPoints:o,wrapperRef:s,onAreaClick:d,mapName:c}=e,u=(0,l.jsxs)("div",{ref:s,className:"".concat(M().imageWrapper," imageWrapper"),children:[i.areas.length>0&&(0,l.jsx)(ek,{src:t,name:c,areas:i.areas,onClick:d,responsive:!0,parentWidth:n,natural:!0}),r&&o&&(0,l.jsxs)("svg",{className:M().areaGlowOverlay,style:{position:"absolute",top:0,left:0,width:"100%",height:"100%",pointerEvents:"none",overflow:"visible"},viewBox:"0 0 ".concat(r.width," ").concat(r.height),children:[(0,l.jsx)("defs",{children:(0,l.jsxs)("filter",{id:"migraine-nav-glow-".concat(a),x:"-40%",y:"-40%",width:"180%",height:"180%",children:[(0,l.jsx)("feGaussianBlur",{in:"SourceGraphic",stdDeviation:"3",result:"tightBlur"}),(0,l.jsx)("feGaussianBlur",{in:"SourceGraphic",stdDeviation:"10",result:"midBlur"}),(0,l.jsx)("feGaussianBlur",{in:"SourceGraphic",stdDeviation:"22",result:"wideBlur"}),(0,l.jsxs)("feMerge",{children:[(0,l.jsx)("feMergeNode",{in:"wideBlur"}),(0,l.jsx)("feMergeNode",{in:"midBlur"}),(0,l.jsx)("feMergeNode",{in:"tightBlur"}),(0,l.jsx)("feMergeNode",{in:"SourceGraphic"})]})]})}),(0,l.jsx)("polygon",{points:o,style:{fill:"var(--biomarker-color-teal-400)",fillOpacity:.3,stroke:"var(--biomarker-color-teal-400)",strokeWidth:2,strokeOpacity:.6},filter:"url(#migraine-nav-glow-".concat(a,")")}),(0,l.jsx)("polygon",{points:o,style:{fill:"none",stroke:"#ffffff",strokeWidth:2,strokeOpacity:1}})]})]});return"desktop"===a?(0,l.jsx)("div",{className:M().centerColumn,children:u}):u}function ej(e){var a,t,n,r,o,m,p,_,b,g,h,y,x,k,N,w,T,j,C;let{postData:B,preview:P}=e,I=null==B?void 0:B.site_navs,E=null==B?void 0:B.mapped_image,L={backgroundUrl:(0,u.ks)(null==B?void 0:B.biomarker_background_image),returnLogoUrl:null!==(y=(0,u.ks)(null==B?void 0:B.biomarker_return_image))&&void 0!==y?y:(0,u.ks)(null==B?void 0:B.biomarker_header_logo),returnLinkUrl:(null==B?void 0:null===(a=B.biomarker_return_link)||void 0===a?void 0:a.url)||"/",returnLinkTarget:null==B?void 0:null===(t=B.biomarker_return_link)||void 0===t?void 0:t.target,returnText:null==B?void 0:B.biomarker_return_text,subtitle:null==B?void 0:B.biomarker_subheading_text,titleColor:null==B?void 0:B.biomarker_heading_text_color,returnTextColor:null==B?void 0:B.biomarker_return_text_color,subtitleColor:null==B?void 0:B.biomarker_subheading_text_color,pageBgColor:null==B?void 0:B.page_bg_color,primaryMenuBg:null==B?void 0:B.primary_menu_bg,primaryMenuTextColor:null==B?void 0:B.primary_menu_text_color,primaryMenuHover:null==B?void 0:B.primary_menu_hover,primaryMenuActive:null==B?void 0:B.primary_menu_active,migraineLayout:!0},R={pageBgColor:null==B?void 0:B.page_bg_color,tabColorHover:null==B?void 0:B.tab_color_hover,tabColorActiveHover:null==B?void 0:B.tab_color_active_hover,pipelineBgColor:null==B?void 0:B.pipeline_bg_color,secondBgTableColor:null==B?void 0:B.second_bg_table_color,tabColor:null==B?void 0:B.tab_color,tabColorActive:null==B?void 0:B.tab_color_active,tableBodyBg:null==B?void 0:B.table_body_bg,tableBodySubtitle:null==B?void 0:B.table_body_subtitle,tableBodyTitle:null==B?void 0:B.table_body_title,tableHeaderBg:null==B?void 0:B.table_header_bg,tableTitle:null==B?void 0:B.table_title},H=null==E?void 0:E.areas,O=(0,i.useMemo)(()=>(null!=H?H:[]).map((e,a)=>({area:e,id:eN(e,String(a))}

1)),[H]),D=(0,i.useMemo)(()=>ew(H),[H]),W=(0,i.useMemo)(()=>ew(H).map(e=>{let{id:a,label:t}=e;return{id:a,label:t}}),[H]),F=(0,s.A)("(max-width: 767px)",{noSsr:!0}),[V,U]=(0,i.useState)(!1);(0,i.useEffect)(()=>{U(!0)},[]);let z=V&&F,[q,G]=(0,i.useState)(null),[Y,J]=(0,i.useState)(0),[X,K]=(0,i.useState)(!1),[Z,Q]=(0,i.useState)(!1),[ee,ea]=(0,i.useState)(800),[et,el]=(0,i.useState)(null),[ei,en]=(0,i.useState)(""),er=(0,i.useRef)(null),eo=(0,i.useRef)(null),es=(0,i.useMemo)(()=>0===D.length?"":null!=q&&D.some(e=>e.id===q)?q:D[0].id,[D,q]),ed=null!==(k=null!==(x=null===(n=O.find(e=>e.id===es))||void 0===n?void 0:n.id)&&void 0!==x?x:null===(r=O[0])||void 0===r?void 0:r.id)&&void 0!==k?k:"",ec=(0,i.useMemo)(()=>O.length?{name:"migraine-navigator-map",areas:O.map(e=>{let{area:a,id:t}=e,l=t===ed;return{id:t,shape:a.shape,coords:a.coords,name:a.name,active:l,preFillColor:l&&ei?ei.replace(/,\s*[\d.]+\)$/,", 0.2)"):a.preFillColor||"rgba(255, 255, 255, 0.04)",fillColor:l&&ei?ei.replace(/,\s*[\d.]+\)$/,", 0.35)"):a.fillColor||"rgba(0, 115, 170, 0.35)",strokeColor:l&&ei?ei.replace(/,\s*[\d.]+\)$/,", 0.9)"):a.strokeColor||"rgba(100, 140, 180, 0.5)",lineWidth:l?2:a.lineWidth||1,_data:a}})}:{name:"migraine-navigator-map",areas:[]},[O,ed,ei]),ev=null!==(w=null!==(N=O.find(e=>{let{id:a}=e;return a===ed}))&&void 0!==N?N:O[0])&&void 0!==w?w:null,em=null!==(T=null==ev?void 0:null===(m=ev.area)||void 0===m?void 0:null===(o=m.mainTitle)||void 0===o?void 0:o.trim())&&void 0!==T?T:"",e_=null!==(j=null==ev?void 0:null===(_=ev.area)||void 0===_?void 0:null===(p=_.description)||void 0===p?void 0:p.trim())&&void 0!==j?j:"",eb=em.length>0||e_.length>0,ef=(0,i.useMemo)(()=>{if(!ev)return null;let e=ev.area.coords,a=[];for(let t=0;t+1<e.length;t+=2)a.push("".concat(e[t],",").concat(e[t+1]));return a.join(" ")},[ev]),ek=!!((null==E?void 0:E.image_url)&&O.length>0),ej=(0,i.useMemo)(()=>{var e;if(!es)return[];let a=O.find(e=>e.id===es),t=null==a?void 0:a.area;return(null==t?void 0:null===(e=t.items)||void 0===e?void 0:e.length)?t.items.flatMap((e,a)=>$(e,"".concat(es,"-item-").concat(a))):[]},[es,O]),eC=(0,i.useMemo)(()=>{var e;if(!es)return[];let a=O.find(e=>e.id===es);return(0,v.yv)(null==a?void 0:null===(e=a.area)||void 0===e?void 0:e.cards)},[es,O]),eB=(0,i.useMemo)(()=>{var e,a,t;let l=null===(e=W.find(e=>e.id===es))||void 0===e?void 0:e.label;return l||(null!==(t=null===(a=D.find(e=>e.id===es))||void 0===a?void 0:a.label)&&void 0!==t?t:"Insights")},[W,es,D]),eS=(0,i.useCallback)(function(){let e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];Q(!1),e&&K(!0)},[]),eA=(0,i.useCallback)(e=>{G(e),Q(!0)},[]);(0,i.useEffect)(()=>{J(0)},[es]),(0,i.useEffect)(()=>{if("undefined"!=typeof document&&F&&(X||Z)){let e=document.documentElement,a=e.style.overflow,t=document.body.style.overflow;return e.style.overflow="hidden",document.body.style.overflow="hidden",()=>{e.style.overflow=a,document.body.style.overflow=t}}},[F,X,Z]),(0,i.useEffect)(()=>{F||(K(!1),Q(!1),"undefined"==typeof document||(document.documentElement.style.overflow="",document.body.style.overflow=""))},[F]),(0,i.useEffect)(()=>{let e=()=>{window.innerWidth>=768&&Z&&(Q(!1),document.documentElement.style.overflow="",document.body.style.overflow="")};return window.addEventListener("resize",e),()=>window.removeEventListener("resize",e)},[Z]),(0,i.useEffect)(()=>{let e=null==E?void 0:E.image_url;if(!e)return;let a=new window.Image;a.onload=()=>el({width:a.naturalWidth,height:a.naturalHeight}),a.src=e},[null==E?void 0:E.image_url]),(0,i.useEffect)(()=>{var e;let a=null!==(e=er.current)&&void 0!==e?e:eo.current;a&&en(getComputedStyle(a).getPropertyValue("--biomarker-color-teal-400").trim()||"rgba(0, 213, 190, 1)")},[ek,F]);let eP=(0,i.useCallback)(()=>{requestAnimationFrame(()=>{let e=window.innerWidth>=768?er.current:eo.current;if(!e)return;let a=e.getBoundingClientRect().width;a>0&&ea(Math.round(a))})},[]);(0,i.useEffect)(()=>{if(!ek)return;let e=null,a=()=>{eP(),null!==e&&window.clearTimeout(e),e=window.setTimeout(()=>{e=null,eP()},150)};eP();let t=[er.current,eo.current].filter(e=>null!==e);if("undefined"!=typeof ResizeObserver&&t.length>0){let l=new ResizeObserver(()=>eP());

1return t.forEach(e=>l.observe(e)),window.addEventListener("resize",a),()=>{l.disconnect(),window.removeEventListener("resize",a),null!==e&&window.clearTimeout(e)}}return window.addEventListener("resize",a),()=>{window.removeEventListener("resize",a),null!==e&&window.clearTimeout(e)}},[ek,eP,F]);let eM=(0,i.useCallback)(e=>{var a;if(!e._data)return;let t=e.id||e._data.id,l=O.findIndex(e=>e.id===t);!(l<0)&&(null===(a=window.dataLayer)||void 0===a||a.push({event:"nav_engage",navigator_product:"migraine",anatomy_area:t,interaction_type:"click",line_item_id:l,post_id:B.ID}),G(t),F&&(K(!1),Q(!0)))},[O,B.ID,F]),eI=B.post_title||"Migraine navigator",eE=D.map(e=>{var a;let t=O.find(a=>a.id===e.id),i=null==t?void 0:t.area,n=e.id,r=null!==(a=null==i?void 0:i.items.flatMap((e,a)=>$(e,"".concat(n,"-item-").concat(a))))&&void 0!==a?a:[],o=(0,v.yv)(null==i?void 0:i.cards);return(0,l.jsx)("div",{role:"tabpanel",id:"migraine-nav-panel-".concat(e.id),"aria-labelledby":"migraine-nav-tab-".concat(e.id),hidden:es!==e.id,className:ey().tabPanel,children:r.length>0?(0,l.jsx)("div",{className:ey().cancerPanelWrap,children:(0,l.jsx)(eu,{panels:r,className:ey().cancerPanel,defaultExpanded:!1,promoCards:o})}):null},e.id)}),eL=e=>(null==E?void 0:E.image_url)?(0,l.jsx)(eT,{variant:e,imageUrl:E.image_url,mapperData:ec,imageWidth:ee,naturalImageSize:et,activeAreaPolygonPoints:ef,wrapperRef:"desktop"===e?er:eo,onAreaClick:eM,mapName:"desktop"===e?"migraine-navigator-map":"migraine-navigator-map-mobile"}):null;if(!E)return(0,l.jsx)(c.A,{sitenavs:I,preview:P,header_type:"BiomarkerNavigator",navigator_header_title:(null==B?void 0:B.biomarker_heading_text)||(null==B?void 0:B.post_title)||ex,navigator_header_link:(null==B?void 0:B.biomarker_header_text_link)||((null==B?void 0:B.slug)?"/navigator/".concat(B.slug):void 0),navigator_config:L,navigator_theme:R,children:(0,l.jsx)("div",{className:ey().loading,children:"No mapped_image data available"})});if(!E.image_url)return(0,l.jsx)(c.A,{sitenavs:I,preview:P,header_type:"BiomarkerNavigator",navigator_header_title:(null==B?void 0:B.biomarker_heading_text)||(null==B?void 0:B.post_title)||ex,navigator_header_link:(null==B?void 0:B.biomarker_header_text_link)||((null==B?void 0:B.slug)?"/navigator/".concat(B.slug):void 0),navigator_config:L,navigator_theme:R,children:(0,l.jsx)("div",{className:ey().loading,children:"Mapped image URL is missing"})});let eR=ek&&D.length>0?(0,l.jsxs)("div",{className:M().mobileBodyMapWrapper,children:[(0,l.jsx)("button",{type:"button",className:"".concat(M().hamburgerButton," ").concat(X||Z?M().hamburgerButtonHidden:""),onClick:()=>K(!0),"aria-label":"Open migraine type menu","aria-hidden":X||Z,disabled:X||Z,children:(0,l.jsx)("img",{src:"/icons/biomarker_mobile_hamburger_icon.svg",alt:"",className:M().hamburgerIcon,width:24,height:19,"aria-hidden":!0})}),(0,l.jsx)(eh,{open:X,onClose:()=>K(!1),options:W,selectedId:es,onSelectType:eA}),eL("mobile"),Z?(0,l.jsxs)("div",{className:M().mobileBiomarkerOverlay,role:"dialog","aria-modal":"true","aria-labelledby":"migraine-mobile-drawer-title",children:[(0,l.jsxs)("div",{className:M().mobileBiomarkerHeader,children:[(0,l.jsx)("button",{type:"button",className:M().mobileBiomarkerHeaderIcon,onClick:()=>eS(!0),"aria-label":"Back to migraine types",children:(0,l.jsx)("img",{src:"/icons/biomarker_caret_down_icon.svg",alt:"",className:M().mobileBiomarkerHeaderBackIcon,width:20,height:20,"aria-hidden":!0})}),(0,l.jsx)("h2",{id:"migraine-mobile-drawer-title",className:M().mobileBiomarkerTitle,children:eB}),(0,l.jsx)("button",{type:"button",className:M().mobileBiomarkerHeaderIcon,onClick:()=>eS(!1),"aria-label":"Close panel",children:(0,l.jsx)("img",{src:"/icons/biomarker_close_icon.svg",alt:"",className:M().mobileBiomarkerHeaderCloseIcon,width:20,height:20,"aria-hidden":!0})})]}),(0,l.jsx)("div",{className:M().mobileBiomarkerScrollArea,children:ej.length>0?(0,l.jsx)(eu,{panels:ej,className:ey().migraineDrawerStack,defaultExpanded:!1,promoCards:eC}):(0,l.jsx)("p",{className:ey().migraineDrawerEmpty,children:"No content available for this type."})})]}):null]}):(0,l.jsx)("div",{className:ey().mapImageRow,children:(0,l.jsx)("div",{className:M().centerColumn,children:(0,l.jsx)("div",{className:"".concat(M().imageWrapper," imageWrapper"),children:(0,l.jsx)("img",{className:ey().mapImage,src:E.image_url,alt:eI,decoding:"async"})})})}),eH=ek&&D.length>0?(0,l.jsxs)("div",{className:ey().migraineDesktopLayout,children:[(0,l.jsx)(ep,{tabs:D,activeTypeId:es,onTypeChange:G,className:"".concat(ey().typeTabs," ").concat(ey().gridTabs)}),(0,l.jsxs)("div",{className:ey().tabsContent,children:[eb&&(0,l.jsxs)("header",{className:ey().areaIntro,children:[em?(0,l.jsx)("h2",{className:ey().areaIntroTitle,children:em}):null,e_?(0,l.jsx)("p",{className:ey().areaIntroDescription,children:e_}):null]}),(null!==(C=null==ev?void 0:null===(g=ev.area)||void 0===g?void 0:null===(b=g.phases)||void 0===b?void 0:b.length)&&void 0!==C?C:0)>0&&(0,l.jsx)(eg,{phases:ev.area.phases,activeIndex:Y,onPhaseClick:J}),(0,l.jsxs)("div",{className:"".concat(M().desktopContent," ").concat(M().desktopContentMigraine),children:[eL("desktop"),(0,l.jsx)("div",{id:"migraine-cancer-panel-".concat(ed||"default"),className:M().cancerPanelScrollAnchor,children:eE})]})]})]}):(0,l.jsx)("div",{className:ey().mapImageRow,children:(0,l.jsx)("div",{className:M().centerColumn,children:(0,l.jsx)("div",{className:"".concat(M().imageWrapper," imageWrapper"),children:(0,l.jsx)("img",{className:ey().mapImage,src:E.image_url,alt:eI,decoding:"async"})})})});return(0,l.jsx)(c.A,{sitenavs:I,preview:P,header_type:"BiomarkerNavigator",navigator_header_title:(null==B?void 0:B.biomarker_heading_text)||(null==B?void 0:B.post_title)||ex,navigator_header_link:(null==B?void 0:B.biomarker_header_text_link)||((null==B?void 0:B.slug)?"/navigator/".concat(B.slug):void 0),navigator_config:L,navigator_theme:R,children:(0,l.jsx)("div",{className:ey().root,style:(null==B?void 0:B.page_bg_color)?{"--mig-wp-page-bg":B.page_bg_color}:void 0,children:(0,l.jsx)("div",{className:M().page,children:(0,l.jsxs)("div",{className:M().container,children:[(0,l.jsx)(f,{content:null==B?void 0:B.navigator_editor_content}),(0,l.jsx)("h1",{className:M().pageTitle,children:B.post_title||"Migraine"}),z?(0,l.jsx)("div",{className:M().mobileLayout,children:(0,l.jsx)("div",{className:M().mobileSection,children:eR})}):(0,l.jsxs)("div",{className:M().desktopLayout,children:[eH,(0,l.jsx)("aside",{className:M().adsSidebar,suppressHydrationWarning:!0,children:(null==B?void 0:null===(h=B.sidebar_settings)||void 0===h?void 0:h.length)?B.sidebar_settings.map((e,a)=>(0,l.jsx)("div",{suppressHydrationWarning:!0,children:(0,l.jsx)(A.A,{...e})},a)):(0,l.jsx)("div",{className:"ad",children:(0,l.jsxs)(d.A,{direction:"column",spacing:2,sx:{textAlign:"center"},children:[(0,l.jsx)(S.J5,{}),(0,l.jsx)(S.Jo,{})]})})})]})]})})})})}let eC=(0,t(68730).A)("arrow-up-right",[["path",{d:"M7 7h10v10",key:"1tivn9"}],["path",{d:"M7 17 17 7",key:"1vkiza"}]]);var eB=t(52950),eS=t.n(eB);function eA(e){let{options:a,selectedId:t,onSelect:i,className:n,ariaLabel:r="Migraine type"}=e;if(0===a.length)return null;let o=(null==t?void 0:t.trim())||null;

1return(0,l.jsx)("div",{className:[eS().stack,n].filter(Boolean).join(" "),role:"tablist","aria-label":r,children:a.map(e=>{let a=o===e.id;return(0,l.jsx)("button",{type:"button",role:"tab","aria-selected":a,className:"".concat(eS().typeButton," ").concat(a?eS().typeButtonSelected:""),onClick:()=>i(e.id),children:e.label},e.id)})})}function eP(e){let a=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"",t=null==e?void 0:e.trim();return t?[{label:a,html:t}]:[]}function eM(e,a){let t=null==a?void 0:a.trim();if(!(e&&Array.isArray(e)&&e.length>0))return t?{defaultContent:eP(a)}:{};let l=e.map((e,a)=>({id:"tab-".concat(a),label:e.tab_name||"Tab ".concat(a+1)})),i={};e.forEach((e,a)=>{i["tab-".concat(a)]=eP(e.content)});let n={segmentTabs:l,segmentContent:i};return t&&(n.defaultContent=eP(a)),n}function eI(e,a){return{id:e,title:a,contentByPhase:{}}}function eE(e){var a,t;return function e(a){if(null==a||!1===a)return"";if("string"==typeof a)return a.trim();if("number"==typeof a)return String(a).trim();if(Array.isArray(a))return a.map(e).filter(Boolean).join("\n");if("object"==typeof a){if("string"==typeof a.rendered)return a.rendered.trim();if("string"==typeof a.value)return a.value.trim();if("string"==typeof a.text)return a.text.trim()}return""}(null!==(t=null!==(a=e.characteristics)&&void 0!==a?a:e.Characteristics)&&void 0!==t?t:e.characteristic)}function eL(e,a){let t=eE(a),l=eE(e);return{...a,characteristics:t||l||void 0}}function eR(e,a,t){var l,i,n,r,o,s,d;if(e.content_type&&("direct"===e.content_type||"subsections"===e.content_type)||e.content_type&&("direct"===e.content_type||"subsections"===e.content_type))return"direct"===e.content_type&&e.cards&&Array.isArray(e.cards)?e.cards.map((e,a)=>{let{segmentTabs:l,segmentContent:i,defaultContent:n}=eM(!!e.enable_tabs&&e.content_tabs,e.content),r={id:"".concat(t,"-card-").concat(a),title:e.card_name||"Card ".concat(a+1),contentByPhase:{}};return l&&i?(r.segmentTabs=l,r.segmentContent=i,n&&(r.defaultContent=n)):n&&(r.contentByPhase={approved:n}),r}):"subsections"===e.content_type&&e.subsections&&Array.isArray(e.subsections)?e.subsections.flatMap((e,a)=>e.cards&&Array.isArray(e.cards)?e.cards.map((l,i)=>{let{segmentTabs:n,segmentContent:r,defaultContent:o}=eM(!!l.enable_tabs&&l.content_tabs,l.content),s={id:"".concat(t,"-subsection-").concat(a,"-card-").concat(i),title:l.card_name||"".concat(e.name," - Card ").concat(i+1),contentByPhase:{}};return n&&r?(s.segmentTabs=n,s.segmentContent=r,o&&(s.defaultContent=o)):o&&(s.contentByPhase={approved:o}),s}):[]):[];let c=function(e,a){var t,l;let i=function e(a){if(!1===a||null==a)return null;if("string"==typeof a){let t=a.trim();if(!t)return null;if(t.startsWith("[")||t.startsWith("{"))try{return e(JSON.parse(t))}catch(e){return null}let l=V(t);return 0===l.length?null:l.map(e=>({key_point:e}))}if(Array.isArray(a)){let e=a.filter(e=>null!=e&&"object"==typeof e);return e.length>0?e:null}if("object"==typeof a){if(Array.isArray(a.rows))return e(a.rows);if(Array.isArray(a.data))return e(a.data);let t=Object.keys(a);if(t.length>0&&t.every(e=>/^\d+$/.test(e))){let e=t.sort((e,a)=>Number(e)-Number(a)).map(e=>a[e]).filter(e=>null!=e&&"object"==typeof e);return e.length>0?e:null}}return null}(!1===e.differential_diagnosis?null:null!==(l=null!==(t=e.differential_diagnosis)&&void 0!==t?t:e.differentialDiagnosis)&&void 0!==l?l:null),n=eE(e);return{title:a,line_item_id:e.line_item_id||null,...n?{characteristics:n}:{},approved:{prevalence:"",tests:"",therapies:""},pipeline:{prevalence:"",tests:"",therapeutic:""},link:{url:""},symptoms:{visual:{presentation:e.symptoms_visual_presentation,prevalence:e.symptoms_visual_prevalence,timing:e.symptoms_visual_timing},sensory:{presentation:e.symptoms_sensory_presentation,prevalence:e.symptoms_sensory_prevalence,timing:e.symptoms_sensory_timing},speech:{presentation:e.symptoms_speech_presentation,prevalence:e.symptoms_speech_prevalence,timing:e.symptoms_speech_timing}},treatment:{severe:{first_line:e.treatment_severe_first_line,dosage:e.treatment_severe_dosage,efficacy:e.treatment_severe_efficacy},mild:{first_line:e.treatment_mild_first_line,dosage:e.treatment_mild_dosage,efficacy:e.treatment_mild_efficacy}},prevention:{first_line_therapy:e.prevention_first_line_therapy,dosage:e.prevention_dosage,target_population:e.prevention_target_population},...(null==i?void 0:i.length)?{differential_diagnosis:i}:{}}}(e,a),u=$(c,t,{fixedSectionTitles:!0}),v=null!==(i=null!==(l=u.find(e=>"SYMPTOMS"===e.title))&&void 0!==l?l:u.find(e=>{var a,t;return(null!==(t=null===(a=e.segmentTabs)||void 0===a?void 0:a.length)&&void 0!==t?t:0)===3}))&&void 0!==i?i:null,m=null!==(n=u.find(e=>"DIFFERENTIAL DIAGNOSIS"===e.title))&&void 0!==n?n:null,p=null!==(o=null!==(r=u.find(e=>"PREVENTION"===e.title))&&void 0!==r?r:u.find(e=>{var a;return Object.values(null!==(a=e.contentByPhase)&&void 0!==a?a:{}).some(e=>!!Array.isArray(e)&&e.some(e=>/TARGET POPULATION|FIRST LINE THERAPY/i.test(e.label)))}))&&void 0!==o?o:null;return[...(null===(s=c.characteristics)||void 0===s?void 0:s.trim())?[{id:"".concat(t,"-characteristics"),title:"CHARACTERISTICS",contentByPhase:{approved:function(e){let a=e.replace(/<br\s*\/?>/gi,"\n").trim();if(!a)return[];let t=V(a);return t.length?[{label:"",items:t}]:[]}(null!==(d=c.characteristics)&&void 0!==d?d:"")}}]:[],null!=v?v:eI("".concat(t,"-symptoms-empty"),"SYMPTOMS"),...m?[m]:[],null!=p?p:eI("".concat(t,"-prevention-empty"),"PREVENTION")]}var eH=t(94898),eO=t.n(eH);function eD(e){let{phase:a,phaseId:t,openPanelId:i,onOpenPanelChange:n,onPanelExpand:r,onInnerTabChange:o}=e,s=eR(a,a.title||a.phase_name,t),d=(0,v.yv)(a.promo_cards);return(0,l.jsx)("section",{className:eO().phase,"aria-label":a.phase_name,children:s.length>0?(0,l.jsx)(eu,{panels:s,appearance:"tabbed",defaultExpanded:!1,openPanelId:i,onOpenPanelChange:n,onPanelExpand:r,onInnerTabChange:o,promoCards:d}):(0,l.jsx)("p",{className:eO().empty,children:"No content available."})})}var eW=t(67246),eF=t.n(eW);function eV(e){let{phase:a,phaseId:t,activeAreaIndex:i,openPanelId:n,onOpenPanelChange:r,onPanelExpand:o,onInnerTabChange:s}=e,d=Array.isArray(a.areas)?a.areas:[],c=d.length?Math.min(Math.max(0,i),d.length-1):0,u=d[c];return(0,l.jsx)("section",{className:eF().phase,"aria-label":a.phase_name,children:0!==d.length&&u?(0,l.jsx)("div",{className:eF().areasList,children:(0,l.jsx)("div",{className:eF().area,children:(0,l.jsx)(eU,{phase:a,area:u,areaId:"".concat(t,"-area-").concat(c),openPanelId:n,onOpenPanelChange:r,onPanelExpand:o,onInnerTabChange:s})})}):(0,l.jsx)("p",{className:eF().empty,children:0===d.length?"No areas available.":"No content available."})})}function eU(e){let{phase:a,area:t,areaId:i,openPanelId:n,onOpenPanelChange:r,onPanelExpand:o,onInnerTabChange:s}=e,d=eL(a,t),c=eR(d,d.area_title,i),u=(0,v.yv)(t.promo_cards);return 0===c.length?(0,l.jsx)("p",{className:eF().empty,children:"No content available."}):(0,l.jsx)(eu,{panels:c,defaultExpanded:!1,appearance:"tabbed",openPanelId:n,onOpenPanelChange:r,onPanelExpand:o,onInnerTabChange:s,promoCards:u})}var ez=t(29838),eq=t.n(ez);function eG(e){var a,t,l;return!!e&&("string"==typeof e?e||!1:(null!==(l=null!==(t=null!==(a=e.url)&&void 0!==a?a:e.src)&&void 0!==t?t:e.guid)&&void 0!==l?l:"")||!1)}function eY(e){return e&&e.trim().toLowerCase().replace(/[^a-z0-9]+/g,"_").replace(/^_+|_+$/g,"")||null}let eJ={nav_target:null,nav_filter_1:null,nav_filter_2:null,section_title:null,sub_section_title:null,line_item_id:null};function eX(e,a){var t,l;let i=null!==(l=("none"!==a&&Array.isArray(e.phases)?e.phases:[])[0])&&void 0!==l?l:null,n="phase-and-area"===a?eK(i):null;return{nav_target:eY(e.tab_name),nav_filter_1:i?eY(i.phase_name):null,nav_filter_2:n?eY((null===(t=n.area_title)||void 0===t?void 0:t.trim())||"Subtype 1"):null,section_title:null,sub_section_title:null,line_item_id:e.line_item_id||null}}function eK(e){var a;return e&&"areas"===e.phase_type&&Array.isArray(e.areas)&&null!==(a=e.areas[0])&&void 0!==a?a:null}function eZ(e){var a,t,n,r,m,p,_,b,g,h,f,y,x,k;let{postData:N,preview:w}=e,T=(0,o.useRouter)(),j=null==N?void 0:N.site_navs,C={backgroundUrl:(0,u.ks)(null==N?void 0:N.biomarker_background_image),bannerClassName:eq().navigatorBanner,returnLogoUrl:null!==(p=(0,u.ks)(null==N?void 0:N.biomarker_return_image))&&void 0!==p?p:(0,u.ks)(null==N?void 0:N.biomarker_header_logo),returnLinkUrl:(null==N?void 0:null===(a=N.biomarker_return_link)||void 0===a?void 0:a.url)||"/",returnLinkTarget:null==N?void 0:null===(t=N.biomarker_return_link)||void 0===t?void 0:t.target,returnText:null==N?void 0:N.biomarker_return_text,subtitle:null==N?void 0:N.biomarker_subheading_text,titleColor:null==N?void 0:N.biomarker_heading_text_color,returnTextColor:null==N?void 0:N.biomarker_return_text_color,subtitleColor:null==N?void 0:N.biomarker_subheading_text_color,pageBgColor:null==N?void 0:N.page_bg_color,primaryMenuBg:null==N?void 0:N.primary_menu_bg,primaryMenuTextColor:null==N?void 0:N.primary_menu_text_color,primaryMenuHover:null==N?void 0:N.primary_menu_hover,primaryMenuActive:null==N?void 0:N.primary_menu_active,migraineLayout:!0},B={pageBgColor:null==N?void 0:N.page_bg_color,tabColor:null==N?void 0:N.tab_color,tabColorActive:null==N?void 0:N.tab_color_active,tabColorHover:null==N?void 0:N.tab_color_hover,tabColorActiveHover:null==N?void 0:N.tab_color_active_hover,pipelineBgColor:null==N?void 0:N.pipeline_bg_color,secondBgTableColor:null==N?void 0:N.second_bg_table_color,tableBodyBg:null==N?void 0:N.table_body_bg,tableBodySubtitle:null==N?void 0:N.table_body_subtitle,tableBodyTitle:null==N?void 0:N.table_body_title,tableHeaderBg:null==N?void 0:N.table_header_bg,tableTitle:null==N?void 0:N.table_title},P=(0,i.useCallback)(e=>e.toLowerCase().trim().replace(/[^\w\s-]/g,"").replace(/[\s_-]+/g,"-").replace(/^-+|-+$/g,""),[]),I=(0,i.useMemo)(()=>{let e=N.navigator_tabs;return Array.isArray(e)?e.map(e=>({...e,phases:Array.isArray(e.phases)?e.phases.map(e=>(function(e){if("subsections"!==e.content_type||!e.subsections||!Array.isArray(e.subsections))return e;let a=e.subsections.map(e=>({area_title:e.name,line_item_id:e.line_item_id,layer_image:e.layer_image,cards:e.cards,promo_cards:e.promo_cards,content_type:"direct"}));return{...e,phase_type:"areas",areas:a}})(e)):[]})):[]},[N.navigator_tabs]),E=(0,i.useMemo)(()=>I.map((e,a)=>({id:e.tab_name||String(a),label:e.tab_name,index:a})),[I]),L=(0,i.useMemo)(()=>{var e;let a=null===(e=N.slug)||void 0===e?void 0:e.toLowerCase();return a?"/navigator/".concat(a,"/legend"):"/navigator"},[N.slug]),R=(0,s.A)("(max-width: 767px)",{noSsr:!0}),[H,O]=(0,i.useState)(!1);(0,i.useEffect)(()=>{O(!0)},[]);let D=H&&R,W=(0,i.useMemo)(()=>T.isReady?{tab:"string"==typeof T.query.tab?T.query.tab:null,phase:"string"==typeof T.query.phase?T.query.phase:null,area:"string"==typeof T.query.area?T.query.area:null,card:"string"==typeof T.query.card?T.query.card:null}:null,[T.isReady,T.query.tab,T.query.phase,T.query.area,T.query.card]),[F,V]=(0,i.useState)(""),[U,z]=(0,i.useState)(0),[q,G]=(0,i.useState)(0),[Y,J]=(0,i.useState)(null);(0,i.useEffect)(()=>{!F&&E.length>0&&V(E[0].id)},[E,F]);let[X,K]=(0,i.useState)(!1),[Z,Q]=(0,i.useState)(!1),[$,ee]=(0,i.useState)(!1),[ea,et]=(0,i.useState)(!0),el=null!==(_=E.find(e=>e.id===F))&&void 0!==_?_:E[0],ei=null!==(g=I[null!==(b=null==el?void 0:el.index)&&void 0!==b?b:0])&&void 0!==g?g:I[0];null==el||el.label;let en=(0,i.useMemo)(()=>Array.isArray(null==ei?void 0:ei.phases)?ei.phases:[],[ei]),er=null!==(f=null!==(h=en[U])&&void 0!==h?h:en[0])&&void 0!==f?f:null,eo=(0,i.useMemo)(()=>er&&"areas"===er.phase_type&&Array.isArray(er.areas)?er.areas:[],[er]),es=eG(N.background_image),ed=(0,i.useMemo)(()=>

1{if(!er||D&&es&&(!Z||"areas"===er.phase_type&&!$))return!1;if("areas"===er.phase_type&&eo.length>0){var e;let a=Math.min(Math.max(0,q),eo.length-1),t=eG(null===(e=eo[a])||void 0===e?void 0:e.layer_image);if(t)return t;for(let e of eo){let a=eG(e.layer_image);if(a)return a}}return eG(er.layer_image)},[er,eo,q,es,D,Z,$]),ec=es||ed,ev=(0,i.useMemo)(()=>en.map((e,a)=>({label:e.phase_label||"Phase ".concat(a+1),name:e.phase_name,callout:e.phase_callout,duration:e.phase_duration})),[en]),em=(0,i.useCallback)(e=>{if(!er)return[];if("areas"===er.phase_type){let a=Array.isArray(er.areas)?er.areas:[];if(0===a.length)return[];let t=Math.min(Math.max(0,q),a.length-1),l=eL(er,a[t]);return eR(l,l.area_title,"".concat(e,"-area-").concat(t))}return eR(er,er.title||er.phase_name,e)},[er,q]),e_=(0,i.useMemo)(()=>em("tab-".concat(F,"-phase-").concat(U)),[F,U,em]),eb=(0,i.useMemo)(()=>{if(!er)return[];if("areas"===er.phase_type){var e;let a=Array.isArray(er.areas)?er.areas:[];if(0===a.length)return[];let t=Math.min(Math.max(0,q),a.length-1);return(0,v.yv)(null===(e=a[t])||void 0===e?void 0:e.promo_cards)}return(0,v.yv)(er.promo_cards)},[er,q]),eh=(0,i.useMemo)(()=>em("tab-".concat(F,"-phase-").concat(U,"-desktop")),[F,U,em]),ef=(0,i.useMemo)(()=>[...e_,...eh],[e_,eh]),ey=(0,i.useRef)({...eJ}),ex=(0,i.useRef)(!1),ek=(0,i.useCallback)(e=>{var a;let t=ey.current,l=window;l.dataLayer=l.dataLayer||[],l.dataLayer.push({event:"nav_engage",navigator_product:"migraine",nav_target:t.nav_target,nav_filter_1:t.nav_filter_1,nav_filter_2:t.nav_filter_2,section_title:t.section_title,sub_section_title:t.sub_section_title,sub_section_stage:null,interaction_type:e,line_item_id:t.line_item_id,post_id:null!==(a=null==N?void 0:N.ID)&&void 0!==a?a:null})},[null==N?void 0:N.ID]),eN=(0,i.useCallback)((e,a)=>{ey.current=eX(e,a),ek("click")},[ek]),ew=(0,i.useCallback)((e,a)=>{var t;let l=eK(null!=a?a:null);ey.current={...ey.current,nav_filter_1:eY(e),nav_filter_2:l?eY((null===(t=l.area_title)||void 0===t?void 0:t.trim())||"Subtype 1"):null,section_title:null,sub_section_title:null},ek("click")},[ek]),eT=(0,i.useCallback)(e=>{ey.current={...ey.current,nav_filter_2:eY(e),section_title:null,sub_section_title:null},ek("click")},[ek]),ej=(0,i.useCallback)((e,a)=>{ey.current={...ey.current,section_title:eY(e),sub_section_title:a?eY(a):null},ek("view")},[ek]),eB=(0,i.useCallback)((e,a)=>{ey.current={...ey.current,section_title:eY(e),sub_section_title:eY(a)},ek("view")},[ek]);(0,i.useEffect)(()=>{var e,a,t,l,i,n;if(!W||!T.isReady)return;let r=!1,o=0,s=0,d=null,c=null,u=null;if(null!==W.tab){let a=E.find(e=>e.id===W.tab);a&&(V(a.id),d=null!==(e=I[o=a.index])&&void 0!==e?e:null,r=!0)}let v=null!==(a=I[o])&&void 0!==a?a:I[0];d||(d=null!=v?v:null);let m=Array.isArray(null==v?void 0:v.phases)?v.phases:[];if(null!==W.phase&&m.length>0){let e=m.findIndex(e=>P(e.phase_name||e.phase_label||"")===W.phase);-1!==e&&(z(e),Q(!0),s=e,c=null!==(t=m[e])&&void 0!==t?t:null,r=!0)}if(null!==W.area){let e=null!==(l=m[s])&&void 0!==l?l:null;if((null==e?void 0:e.phase_type)==="areas"){let a=Array.isArray(e.areas)?e.areas:[],t=a.findIndex(e=>P(e.area_title||"")===W.area);-1!==t&&(G(t),ee(!0),u=null!==(i=a[t])&&void 0!==i?i:null,r=!0)}}r&&D&&K(!0),r&&!ex.current&&d&&(ex.current=!0,ey.current={nav_target:eY(d.tab_name),nav_filter_1:c?eY(c.phase_name):null,nav_filter_2:u?eY((null===(n=u.area_title)||void 0===n?void 0:n.trim())||"Subtype 1"):null,section_title:null,sub_section_title:null,line_item_id:d.line_item_id||null},W.card||ek("view"))},[W,T.isReady,I,E,D,P,ek]);let eS=(0,i.useRef)(!1);(0,i.useEffect)(()=>{if(!(null==W?void 0:W.card)||0===ef.length||eS.current)return;eS.current=!0;let e=ef.find(e=>e.title===W.card);e?(J(e.id),ej(e.title,null)):ek("view")},[null==W?void 0:W.card,ef,ej,ek]);let eP=(0,i.useCallback)(()=>{var e,a,t;if(!T.isReady)return;let l=new URLSearchParams(window.location.search);l.set("tab",F);let i=null!==(t=I[Number(null!==(a=null===(e=E.find(e=>e.id===F))||void 0===e?void 0:e.index)&&void 0!==a?a:0)])&&void 0!==t?t:I[0],n=(Array.isArray(null==i?void 0:i.phases)?i.phases:[])[U];if(n){let e=P(n.phase_name||n.phase_label||"");e&&l.set("phase",e)}else l.delete("phase");if(eo.length>0&&eo[q]){let e=P(eo[q].area_title||"");e&&l.set("area",e)}else l.delete("area");if(Y&&ef.length>0){let e=ef.find(e=>e.id===Y);(null==e?void 0:e.title)&&l.set("card",e.title)}else l.delete("card");let r=l.toString();r!==window.location.search.substring(1)&&window.history.replaceState(null,"","?".concat(r))},[T.isReady,F,U,q,eo,I,E,P,Y,ef]);(0,i.useEffect)(()=>{G(0)},[F,U]),(0,i.useEffect)(()=>{eP()},[eP]),(0,i.useEffect)(()=>{Z&&et(!0)}

1,[Z]),(0,i.useEffect)(()=>{var e;if(!H||!T.isReady||ex.current||(ex.current=!0,D))return;let a=null!==(e=I[0])&&void 0!==e?e:null;a&&(ey.current=eX(a,"phase-and-area"),ek("view"))},[H,T.isReady,D,I,ek]);let eM=(0,i.useCallback)(e=>{var a,t,l;V(e),K(!0),et(!0);let i=null!==(a=E.find(a=>a.id===e))&&void 0!==a?a:E[0],n=null!==(l=I[null!==(t=null==i?void 0:i.index)&&void 0!==t?t:0])&&void 0!==l?l:I[0],r=Array.isArray(null==n?void 0:n.phases)?n.phases:[];if(r.length>0){z(0),Q(!0);let e=r[0];ee(!!((null==e?void 0:e.phase_type)==="areas"&&Array.isArray(e.areas)&&e.areas.length>0))}else Q(!1),ee(!1);n&&eN(n,"phase")},[E,I,eN]),eI=(0,i.useCallback)(e=>{var a,t,l,i;z(e),Q(!0);let n=null!==(a=E.find(e=>e.id===F))&&void 0!==a?a:E[0],r=null!==(l=I[null!==(t=null==n?void 0:n.index)&&void 0!==t?t:0])&&void 0!==l?l:I[0],o=null!==(i=(Array.isArray(null==r?void 0:r.phases)?r.phases:[])[e])&&void 0!==i?i:null;ee(!!((null==o?void 0:o.phase_type)==="areas"&&Array.isArray(o.areas)&&o.areas.length>0)),o&&ew(o.phase_name,o)},[F,I,E,ew]),eE=eo.length>0?(0,l.jsxs)("div",{className:eq().subtypeRow,role:"tablist","aria-label":"Subtype",children:[(0,l.jsx)("span",{className:eq().subtypeLabel,children:"SUBTYPE"}),(0,l.jsx)("div",{className:eq().subtypePills,children:eo.map((e,a)=>{var t;return(0,l.jsx)("button",{type:"button",role:"tab","aria-selected":q===a,className:"".concat(eq().subtypePill," ").concat(q===a?eq().subtypePillActive:""),onClick:()=>{var t;G(a),ee(!0),Q(!0),eT((null===(t=e.area_title)||void 0===t?void 0:t.trim())||"Subtype ".concat(a+1))},children:(null===(t=e.area_title)||void 0===t?void 0:t.trim())||"Subtype ".concat(a+1)},"".concat(F,"-").concat(U,"-subtype-").concat(a))})})]}):null,eH=!D||X||ea,eO=ec?(0,l.jsxs)("div",{className:eq().figureMapArea,children:[(0,l.jsxs)("div",{className:"".concat(M().imageWrapper," imageWrapper"),children:[(0,l.jsx)("img",{src:ec,alt:null!==(y=null==ei?void 0:ei.tab_name)&&void 0!==y?y:"",className:eq().mapImage,decoding:"async"}),es&&ed&&(0,l.jsx)("img",{src:ed,alt:null!==(x=null==er?void 0:er.phase_name)&&void 0!==x?x:"",className:eq().layerOverlay,decoding:"async"})]}),eH?(0,l.jsxs)("a",{href:L,className:"".concat(eq().viewLegendButton," ").concat(D&&X?eq().viewLegendButtonTopRight:"").trim(),children:[(0,l.jsx)("span",{className:eq().viewLegendLabel,children:"View legend"}),(0,l.jsx)(eC,{className:eq().viewLegendIcon,size:16,strokeWidth:2,"aria-hidden":!0})]}):null]}):null,eW=(0,l.jsxs)("div",{className:"".concat(M().mobileBodyMapWrapper," ").concat(eq().mobileBodyMapWrapperTabbed),children:[X?(0,l.jsxs)("div",{className:eq().mobileState2,children:[E.length>0?(0,l.jsx)(ep,{tabs:E,activeTypeId:F,onTypeChange:e=>{var a,t,l;V(e),K(!0);let i=null!==(a=E.find(a=>a.id===e))&&void 0!==a?a:E[0],n=null!==(l=I[null!==(t=null==i?void 0:i.index)&&void 0!==t?t:0])&&void 0!==l?l:I[0],r=Array.isArray(null==n?void 0:n.phases)?n.phases:[];if(r.length>0){z(0),Q(!0),et(!0);let e=r[0];ee(!!((null==e?void 0:e.phase_type)==="areas"&&Array.isArray(e.areas)&&e.areas.length>0))}else Q(!1),ee(!1);n&&eN(n,"phase")},className:"".concat(eq().typeTabs," ").concat(eq().gridTabs),ariaLabel:"Migraine type"}):null,ev.length>0?(0,l.jsx)("div",{className:eq().mobilePhaseRow,children:(0,l.jsx)(eg,{appearance:"tabbed",phases:ev,activeIndex:Z?U:-1,onPhaseClick:eI,className:eq().mobilePhaseTimeline})}):null,Z?eE:null,(0,l.jsx)("div",{className:eq().mobileBody,children:eO}),Z?(0,l.jsxs)("div",{className:"".concat(eq().mobileSheet," ").concat(eq().mobileSheetCollapsed," ").concat(ea?eq().mobileSheetExpanded:""),role:"region","aria-label":"Details",children:[(0,l.jsxs)("button",{type:"button",className:eq().mobileSheetHeader,onClick:()=>et(!ea),"aria-label":ea?"Tap to collapse":"Tap to expand",children:[(0,l.jsx)("span",{className:eq().mobileSheetHandle,"aria-hidden":!0}),(0,l.jsxs)("span",{className:eq().mobileSheetTitle,children:[null!==(k=null===(n=ev[U])||void 0===n?void 0:n.name)&&void 0!==k?k:"Phase",$&&(null===(r=eo[q])||void 0===r?void 0:r.area_title)?" • ".concat(eo[q].area_title):""]}),(0,l.jsx)("span",{className:eq().mobileSheetHint,children:ea?"Tap to Collapse":"Tap to Open"})]}),(0,l.jsx)("div",{className:eq().mobileSheetCollapsedBody,children:(0,l.jsx)(eu,{panels:e_,appearance:"tabbed",defaultExpanded:!1,layout:"sheet",openPanelId:Y,onOpenPanelChange:J,onPanelExpand:ej,onInnerTabChange:eB,promoCards:eb})})]}):null]}):(0,l.jsxs)("div",{className:eq().mobileTypePickerShell,children:[(0,l.jsx)("div",{className:eq().mobileBody,children:eO}),E.length>0?(0,l.jsx)("div",{className:eq().mobileTypeStackOverlay,children:(0,l.jsx)(eA,{options:E,selectedId:null,onSelect:eM})}):null]}),(0,l.jsx)(S.Ej,{})]}),eF=(0,l.jsx)("div",{className:eq().migraineDesktopLayout,children:(0,l.jsx)("div",{className:eq().tabsContent,children:(0,l.jsxs)("div",{className:eq().tabbedDesktopShell,children:[(0,l.jsxs)("div",{className:eq().tabbedLeftRail,children:[E.length>0&&(0,l.jsx)(ep,{tabs:E,activeTypeId:F,onTypeChange:e=>{var a,t,l;V(e);let i=null!==(a=E.find(a=>a.id===e))&&void 0!==a?a:E[0],n=null!==(l=I[null!==(t=null==i?void 0:i.index)&&void 0!==t?t:0])&&void 0!==l?l:null;n&&eN(n,"phase-and-area")},className:"".concat(eq().typeTabs," ").concat(eq().gridTabs)}),ev.length>0&&(0,l.jsxs)("div",{className:eq().phaseRow,children:[(0,l.jsx)("span",{className:eq().phaseLabel,children:"PHASE"}),(0,l.jsx)(eg,{appearance:"tabbed",phases:ev,activeIndex:U,onPhaseClick:eI,className:eq().phaseTimeline})]}),eE,(0,l.jsx)("div",{className:"".concat(M().centerColumn," ").concat(eq().tabbedFigureColumn),children:eO})]}),(0,l.jsx)("div",{className:eq().tabbedStackColumn,children:(0,l.jsxs)("div",{className:M().cancerPanelScrollAnchor,children:[(e=>{if(!er)return null;let a="tab-".concat(F,"-phase-").concat(U,"-").concat(e);return"areas"===er.phase_type?(0,l.jsx)(eV,{phase:er,phaseId:a,activeAreaIndex:q,openPanelId:Y,onOpenPanelChange:J,onPanelExpand:ej,onInnerTabChange:eB}):(0,l.jsx)(eD,{phase:er,phaseId:a,openPanelId:Y,onOpenPanelChange:J,onPanelExpand:ej,onInnerTabChange:eB})})("desktop"),(0,l.jsx)(S.Ej,{})]})})]})})});return(0,l.jsx)(c.A,{sitenavs:j,preview:w,header_type:"BiomarkerNavigator",navigator_header_title:(null==N?void 0:N.biomarker_heading_text)||(null==N?void 0:N.post_title),navigator_header_link:(null==N?void 0:N.biomarker_header_text_link)||((null==N?void 0:N.slug)?"/navigator/".concat(N.slug):void 0),navigator_config:C,navigator_theme:B,children:(0,l.jsx)("div",{className:eq().root,children:(0,l.jsx)("div",{className:M().page,children:(0,l.jsx)("div",{className:M().container,children:D?(0,l.jsx)("div",{className:"".concat(M().mobileLayout," ").concat(eq().mobileLayout),children:(0,l.jsx)("div",{className:M().mobileSection,children:eW})}):(0,l.jsxs)("div",{className:"".concat(M().desktopLayout," ").concat(eq().desktopLayout),children:[eF,(0,l.jsx)("aside",{className:"".concat(M().adsSidebar," ").concat(eq().adsSidebar),suppressHydrationWarning:!0,children:(null==N?void 0:null===(m=N.sidebar_settings)||void 0===m?void 0:m.length)?N.sidebar_settings.map((e,a)=>(0,l.jsx)("div",{suppressHydrationWarning:!0,children:(0,l.jsx)(A.A,{...e})},a)):(0,l.jsx)("div",{className:"ad",children:(0,l.jsxs)(d.A,{direction:"column",spacing:2,sx:{textAlign:"center"},children:[(0,l.jsx)(S.J5,{}),(0,l.jsx)(S.Jo,{})]})})})]})})})})})}var eQ=!0;function e$(e){var a,t;let{postData:i,preview:n,previewData:r}=e,o=null==i?void 0:null===(a=i.slug)||void 0===a?void 0:a.toLowerCase();if(!o)return null;switch("tabbed"===(t=i.navigator_data_type)?"tabbed":"structured_data"===t||"migraine"===o?"structured_data":"link_based"){case"tabbed":return(0,l.jsx)(eZ,{postData:i,preview:n});case"structured_data":return(0,l.jsx)(ej,{postData:i,preview:n});default:return(0,l.jsx)(F,{postData:i,preview:n,previewData:r})}}},89134:e=>{e.exports={panel:"BiomarkerAccordionPanel_panel__Mqucz",accordionButton:"BiomarkerAccordionPanel_accordionButton__h75kk",chevron:"BiomarkerAccordionPanel_chevron__F_RuJ",contentSlideWrapper:"BiomarkerAccordionPanel_contentSlideWrapper__5XkCn",accordionContent:"BiomarkerAccordionPanel_accordionContent__isYkm",title:"BiomarkerAccordionPanel_title__1bTfS",tabsRow:"BiomarkerAccordionPanel_tabsRow__R1q5J",innerTab:"BiomarkerAccordionPanel_innerTab__eVm24",innerTabActive:"BiomarkerAccordionPanel_innerTabActive__rfqkH",contentContainer:"BiomarkerAccordionPanel_contentContainer__e1KcO",noData:"BiomarkerAccordionPanel_noData__Z90xI",contentBlock:"BiomarkerAccordionPanel_contentBlock__1hUyP",contentBlockWithIcon:"BiomarkerAccordionPanel_contentBlockWithIcon__ZLy3X",contentItems:"BiomarkerAccordionPanel_contentItems__sx3zV",contentLabel:"BiomarkerAccordionPanel_contentLabel__Og6xm",contentLabelIcon:"BiomarkerAccordionPanel_contentLabelIcon__Uik2U",viewMore:"BiomarkerAccordionPanel_viewMore__K0DwW",panelTabbed:"BiomarkerAccordionPanel_panelTabbed__jKVMa",tabsRowScroll:"BiomarkerAccordionPanel_tabsRowScroll__wyL7c",htmlContent:"BiomarkerAccordionPanel_htmlContent__hJsW9"}},89478:e=>{e.exports={root:"MigrainePhaseTimeline_root__w2nmy",timelineBar:"MigrainePhaseTimeline_timelineBar__d64hH",timelineBarInner:"MigrainePhaseTimeline_timelineBarInner__jNEPB",activeIndicator:"MigrainePhaseTimeline_activeIndicator__rslme",lineFill:"MigrainePhaseTimeline_lineFill__UHetl",phaseButton:"MigrainePhaseTimeline_phaseButton__EzJJq",phaseButtonActive:"MigrainePhaseTimeline_phaseButtonActive__vedAB",phaseTitle:"MigrainePhaseTimeline_phaseTitle__d3zDR",phaseNumber:"MigrainePhaseTimeline_phaseNumber__D6i6B",phaseMeta:"MigrainePhaseTimeline_phaseMeta__w3CoM",phaseDescription:"MigrainePhaseTimeline_phaseDescription__aU_2j",rootTabbed:"MigrainePhaseTimeline_rootTabbed___wjoV",tabbedSegmentBar:"MigrainePhaseTimeline_tabbedSegmentBar__DUt5w",tabbedSegmentLabel:"MigrainePhaseTimeline_tabbedSegmentLabel__B699m"}},94898:e=>{e.exports={phase:"TabbedMetadataPhase_phase__g9_Ui",phaseName:"TabbedMetadataPhase_phaseName__DDXuf",empty:"TabbedMetadataPhase_empty__LiAYa"}}},e=>{var a=a=>e(e.s=a);e.O(0,[5588,6117,1418,5571,8012,3565,636,6593,8792],()=>a(26258)),_N_E=e.O()}]);