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60 61 62 <title>Mutation Surveyor</title> 63 </head> 64 <body> 65<section class="topbar"> 66 <div class="container"> 67 <div class="row"> 68 <div class="col-12 col-lg-2"> 69 <a href="https://www.dotmatics.com/" target="_blank" class="link"> 70 <img class="image" alt="dotmatics logo" src="/assets/images/dotmatics-bar/dotmatics-logo-white.svg" /> 71 </a> 72 </div> <!-- col --> 73 <div class="col-12 col-lg-10"> 74 <span class="link collapsed" data-bs-toggle="collapse" data-bs-target="#collapseExplore" data-bs-parent="collapseGroup" aria-expanded="false" aria-controls="collapseExplore" style="cursor: pointer;"> 75 Explore the Scientific R&D Platform 76 </span> 77 </div> <!-- col --> 78 79 </div> <!-- row --> 80 </div> <!-- container --> 81 <div id="collapseGroup"> 82 <div class="collapse topbar-collapsible" id="collapseExplore" data-bs-parent="#collapseGroup"> 83 <div class="container"> 84 <div class="row"> 85 <div class="col-12 col-md-4 col-lg-3 py-3 pe-5"> 86 <div class="py-4"><img 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429 background-position-x: 95%; 430 background-position-y: 70%; 431 } 432.productTitle { 433 font-size: 58.46px; 434 height:255px; 435 } 436} 437 438@media only screen and (min-width: 768px) and (max-width: 991px){ 439.productHeros { 440 background-size: 400px 271px; 441 background-position-x: 95%; 442 background-position-y: 110%; 443 } 444.productTitle { 445 font-size: 58.46px; 446 height:255px; 447 } 448} 449 450/* TABLET VERTICAL */ 451@media only screen and (min-width: 992px) and (max-width: 1199px) { 452.productHeros { 453 background-size: 553px 375px; 454 background-position-x: 80%; 455 background-position-y: 30%; 456 } 457.productTitle { 458 font-size: 48px; 459 } 460} 461 462</style> 463<div class="productHeros"> 464<div class="container mb-5"> 465 <div class="row"> 466 <div class="col-12 d-flex align-items-center productTitle"> 467 <div>Mutation Surveyor<br><span class="productSub">DNA Variant Analysis Software</span></div> 468 </div> 469 </div> 470</div> 471</div> 472 473 474 475 476 477 <!-- BEGIN main content area --> 478 <div class="main"> 479 <div class="container"> 480 <div class="row"> 481 <div class="col-xl-8 col-lg-8 col-md-12 col-sm-12 col-12 pt-10 pe-5"> 482 <h1 class="product-name">Mutation Surveyor® DNA Variant Analysis Software</h1> 483 <p class="product-intro">Mutation Surveyor software includes patented anti-correlation technology, which physically compares sample sequence traces to a reference trace, providing accuracy up to 99.5% with Phred 20 bi-directional sequences and a sensitivity of 5% of the primary peak.</p> 484 <p class="product-mid-weight">A Unique tool for DNA Variant Analysis from Sanger Sequencing Traces</p> 485 <p>Mutation Surveyor® software is a powerful and accurate DNA Sequencing analysis tool for Sanger Sequencing files generated by the following electrophoresis systems:</p> 486 <ul> 487 <li>Applied Biosystems Genetic Analyzers</li> 488 <li>Beckman CEQ</li> 489 <li>Promega Spectrum Compact CE System</li> 490 </ul> 491 <div class="download-trial"> 492 <div class="row download-trial-R"> 493 <div class="col-4 text-center my-auto"> 494 <a class="default-btn btn-bg-two border-radius-50" href="/information/request-trial/">Free 35-day Trial <img src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABgAAAAYCAYAAADgdz34AAAAAXNSR0IArs4c6QAAAMZJREFUSEvtlE0KwjAQhb/eQXDvpndQ0OuI24I3EfeCBxHEMwh6AGnBK2gHKkTEzA8WN802yXx5b96koOdV9FyfAaA6HLFoDeyAm1od3D1YARvgAswtEK+CMXBqFUyAKzAFmpwSL0BqpZBzp+QrJAJ4QQ5ACWQhUYBARsBRg+QAD0tKkjOiZAbc03u/Bkiy3vrxV4tyDpn8lwIRBRJTU4IiANcMRADLdtC2XfYXQK0lLWJRBewt/1BEgfbgj/2IAhdkAKh2PQESzCgZeI9igwAAAABJRU5ErkJggg=="/></a> 495 </div> 496 <div class="col-8 my-auto"> 497 <p class="download-trial-txt">Experience the full potential of <strong>Mutation Surveyor</strong> with a free 35-day trial, and explore our <a href="/PDF/SoftGenetics-GeneticAnalysisPortfolio.pdf" target="blank">complete suite of genetic analysis solutions</a> designed to support your research needs.</p> 498 </div> 499 </div> 500 </div> 501 <p>Capable of performing variant analysis of up to 2000 Sanger sequencing files (.ab1, .RSD, .ESD & .scf) in 15 minutes, Mutation Surveyor delivers excellent accuracy, sensitivity, and low false-positive and false-negative rates in the analysis of DNA variants, including:</p> 502 <ul> 503 <li><a href="/products/mutation-surveyor/anti-correlation-technology/">Single nucleotide polymorphisms</a> (SNPs)</li> 504 <li><a href="/products/mutation-surveyor/indel-detection/">Homozygous insertions and deletions</a> (indels)</li> 505 <li><a href="/products/mutation-surveyor/indel-deconvolution/">Deconvolution and detection</a> of heterozygous indels</li> 506 <li><a href="/products/mutation-surveyor/somatic-mutation-detection/">Somatic mutations</a> in direct sequencing.</li> 507 </ul> 508 <p>The Mutation Surveyor package includes patented anti-correlation technology (U.S. Patent 8,086,410), which physically compares sample sequence traces to a reference trace, providing accuracy up to 99.5% with Phred 20 bi-directional sequences and a sensitivity of 5% of the primary peak.</p> 509 <p>Along with increased accuracy and sensitivity, Mutation Surveyor software features many tools:</p> 510 <ul> 511 <li><a href="/products/mutation-surveyor/custom-reporting/">Custom reporting</a></li> 512 <li>Automated download of annotated GenBank reference files</li> 513 <li><a href="/products/mutation-surveyor/methylation-analysis/">DNA methylation detection</a></li> 514 <li><a href="/products/mutation-surveyor/mitochondrial-dna-sequence-analysis/">Mitochondrial DNA sequence analysis</a></li> 515 <li><a href="/products/mutation-surveyor/mutation-quantification/">Allele quantification</a></li> 516 <li><a href="/products/mutation-surveyor/variant-knowledge-database/">Variant Knowledge Database</a></li> 517 </ul> 518 <p>Mutation Surveyor software includes features designed to enhance and optimize the process of variant discovery in Sanger sequencing traces. The softw
518are can automatically align traces to GRCh37 or GRCh38 GenBank references. And the variant knowledge database allows users to track variants by chromosomal position, indicate false positives and other artifacts, and query mutation annotation information from popular variant databases such as dbSNP, dbNSFP, ClinVar, and gnomAD.</p> 519 520 <p>Also included in Mutation Surveyor software is an intuitive <a href="/products/mutation-surveyor/user-management/">user management</a> system, which enables administrators to set up password-protected user names, control access rights, and generate a user audit trail. Access rights for each user are determined by the administrator, providing assurance that unauthorized individuals do not accidentally alter a project or change the analysis parameters established by the laboratory. User management also provides the user ID in the header of the final reports.</p> 521 522 <hr class="productHR"> 523 <p><strong>Application Notes:</strong></p> 524 <ul class="articles"> 525 <li class="read"><a href="/PDF/MutationSurveyorQuantification.pdf" rel="noopener" target="_blank">DNA Mutation and Methylation Quantification Application Note</a></li> 526 <li class="read"><a href="/PDF/HetIndels_AppNote.pdf" rel="noopener" target="_blank">Heterozygous DNA INDEL Application Note</a></li> 527 <li class="read"><a href="/PDF/NGRLTechnologyAssessment.pdf" rel="noopener" target="_blank">NGRL Technology Assessment</a></li> 528 <li class="read"><a href="/PDF/SequenceAssemblyApplicationNote.pdf" rel="noopener" target="_blank">Sequence Assembly Application Note</a></li> 529 <li class="read"><a href="/PDF/SomaticMutationDetectionTechnicalNote.pdf" rel="noopener" target="_blank">Somatic Mutation Detection Technical Note</a></li> 530 <li class="read"><a href="/PDF/UPMCValidationPoster.pdf" rel="noopener" target="_blank">UPMC Validation Poster</a></li> 531 <li class="read"><a href="/PDF/GeneticDiversityAnalysis_MutationSurveyor_AppNote.pdf" rel="noopener" target="_blank">Genetic Diversity Application Note</a></li> 532 <li class="read"><a href="/PDF/MS_HypervariableMutationDetection_AppNote.pdf" rel="noopener" target="_blank">Hypervariable Mutation Detection</a></li> 533 <li class="read"><a href="/PDF/Methylation_ApplicationNote.pdf" rel="noopener" target="_blank">Methylation Detection Application Note</a></li> 534 <li class="read"><a href="/PDF/Mitochondrial_DNA_SequenceAnalysis_AppNote.pdf" rel="noopener" target="_blank">Mitochondrial DNA Sequence Analysis using Mutation Surveyor® Software</a></li> 535 <li class="read"><a href="/PDF/MS_VariantKnowledgeBase_AppNote.pdf" rel="noopener" target="_blank">Variant Knowledge Base with External Annotation</a></li> 536 <li class="read"><a href="/PDF/MS_UserManagement_AppNote.pdf" rel="noopener" target="_blank">User Management with 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