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1f.render=!0,null==f.fold?f.fold=p.fold:f.fold=p.fold>f.fold?p.fold:f.fold,n.push(f)}}return n=n.sort((function(t,e){return t.fold<e.fold?1:-1})),n.map((function(n){1==n.render&&(e[n.tissue]=t[n.tissue])})),e},addAnnoTrack:function(t){if(""!=t.target.value){var e=this.pkgDataSelected.filter((function(t){return"Annotation"==t.type})).map((function(t){return t.id}));e.indexOf(t.target.value)<0&&(e.push(t.target.value),null!=this.pkgData&&(this.$store.dispatch("pkgDataSelected",{type:"Annotation",id:t.target.value,action:"add"}),l["default"].set(this.pkgData,"selectedAnnos",e)))}},addRemoveTissueTrack:function(t,e){var n=null!=e?e:t.target.value,r=n.replace(/ /g,"_"),a=document.querySelectorAll("input."+r),i=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id}));if(null!=t)if(1==t.target.checked)a.forEach((function(t){t.checked=!0})),i.push(n),null!=this.pkgData&&(this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:n,action:"add"}),l["default"].set(this.pkgData,"selectedTissues",i));else{a.forEach((function(t){t.checked=!1}));var o=i.indexOf(n);o>-1&&null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:n,action:"remove"})}else if(null==t){a.forEach((function(t){t.checked=!1}));var s=i.indexOf(n);s>-1&&null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:n,action:"remove"})}},addTissueTrack:function(t){var e=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id}));""!=t.target.value&&(e.push(t.target.value),null!=this.pkgData&&(this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:t.target.value,action:"add"}),l["default"].set(this.pkgData,"selectedTissues",e)))},renderTissuesTracks:function(){var t=this,e=document.querySelector("#tissuesPlot"),n=document.querySelector("#tissuesPlotWrapper");if(e&&n){var r,a,i=2*this.spaceBy,o=3*this.spaceBy,l=this.spaceBy,c=this.spaceBy,u=(this.spaceBy,this.plotMargin.bump),d=this.viewingRegion.start,h=this.viewingRegion.end,p=2*n.clientWidth,f=this.plotMargin.topMargin,_=p-2*this.plotMargin.leftMargin,g=_/(h-d),m=this.pkgDataSelected.filter((function(t){return"Annotation"==t.type})).map((function(t){return t.id})),v=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id}));v.map((function(e){for(var n=0,r=0,a=Object.entries(t.tissuesData[e]);r<a.length;r++){var u=Object(s["a"])(a[r],2),d=u[0];u[1];1==m.includes(d)&&n++}f+=i+o+c+l*n})),e.setAttribute("width",p),e.setAttribute("height",f),e.setAttribute("style","width:"+p/2+"px;height:"+f/2+"px;"),r=e,a=r.getContext("2d"),a.clearRect(0,0,p,f);var y=this.plotMargin.topMargin;v.map((function(e,n){for(var r=0,c=0,p=Object.entries(t.tissuesData[e]);c<p.length;c++){var f=Object(s["a"])(p[c],2),b=f[0];f[1];1==m.includes(b)&&r++}a.font="28px Arial",a.textAlign="left",a.fillStyle="#000000",a.fillText(e,u,y+t.spaceBy),a.beginPath(),a.fillStyle="#666666",a.lineWidth=0,a.arc(t.plotMargin.leftMargin+_+3*u,y+2*u,14,0,2*Math.PI),a.fill(),a.font="24px Arial",a.textAlign="center",a.fillStyle="#ffffff",a.fillText("â",t.plotMargin.leftMargin+_+3*u,y+2*u+7);var x=Math.ceil((y+2*u)/t.spaceBy),w=t.plotMargin.leftMargin+_+3*u,C=w-7,P=w+7,k=C+"_"+P;if(t.tissuesPosData[x]={tissue:e,annotation:"close",regions:{}},t.tissuesPosData[x].regions[k]="Remove track",y+=i,a.beginPath(),a.strokeStyle="#999999",a.moveTo(t.plotMargin.leftMargin-u,y),a.lineTo(t.plotMargin.leftMargin-u,y+u+l*r),a.stroke(),a.moveTo(t.plotMargin.leftMargin+_+u,y),a.lineTo(t.plotMargin.leftMargin+_+u,y+u+l*r),a.stroke(),a.moveTo(t.plotMargin.leftMargin-u,y+u+l*r),a.lineTo(t.plotMargin.leftMargin+_+u,y+u+l*r),a.stroke(),n+1==v.length)for(var M=(h-d)/5,E=_/5,D=0;D<6;D++){var O=t.plotMargin.leftMargin+D*E,L=Math.floor(O);a.moveTo(L,y+u+l*r),a.lineTo(L,y+2*u+l*r),a.stroke(),a.textAlign="center",a.font="24px Arial",a.fillStyle="#999999";var j=D<5?Number(d)+D*M:Number(h);a.fillText(Math.floor(j),L,y+4*u+l*r)}for(var S=0,A=function(){var n=Object(s["a"])(T[I],2),r=n[0],i=n[1];if(1==m.includes(r)){var o=i.region;S%2==0&&(a.fillStyle="#eeeeee",a.fillRect(t.plotMargin.leftMargin,y,_,l)),S++,a.fillStyle=t.getColorIndex(r);var c=Math.ceil(y/t.spaceBy);

1t.tissuesPosData[c]={tissue:e,annotation:r,regions:{}},o.map((function(e){if(e.start<=h&&e.end>=d){var n=(e.start-d)*g+t.plotMargin.leftMargin;n=n<=t.plotMargin.leftMargin?t.plotMargin.leftMargin:n;var r=(e.end-d)*g+t.plotMargin.leftMargin;r=r>t.plotMargin.leftMargin+_?t.plotMargin.leftMargin+_:r;var i=r-n<1?1:r-n;a.fillRect(n,y,i,l-1);var o=n+"_"+(n+i);t.tissuesPosData[c].regions[o]={start:e.start,end:e.end}}})),y+=l}},I=0,T=Object.entries(t.tissuesData[e]);I<T.length;I++)A();y+=o}))}},removeTissueTrack:function(t){var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=(e.clientX,n.left,Math.ceil(Math.floor(e.clientY-n.top)/this.spaceBy)),i=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id}));if(r>n.width-this.plotMargin.leftMargin&&this.tissuesPosData[a])for(var o=0,l=Object.entries(this.tissuesPosData[a].regions);o<l.length;o++){var c=Object(s["a"])(l[o],2),u=c[0],d=(c[1],u.split("_")),h=d[0],p=d[1];if(r>=h&&r<=p){var f=this.tissuesPosData[a].tissue,_=i.indexOf(f);_>-1&&null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:f,action:"remove"})}}},checkTissuesPosition:function(t){var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=e.clientX-n.left,i=Math.ceil(Math.floor(e.clientY-n.top)/this.spaceBy),o=e.clientY-n.top,l=document.querySelector("#selectedTissueInfoBox"),c="";if(r>=this.plotMargin.leftMargin&&r<=n.width-this.plotMargin.leftMargin){if(this.tissuesPosData[i]){c="close"==this.tissuesPosData[i].annotation?"":this.tissuesPosData[i].annotation;for(var u=0,d=Object.entries(this.tissuesPosData[i].regions);u<d.length;u++){var h=Object(s["a"])(d[u],2),p=h[0],f=h[1],_=p.split("_"),g=_[0],m=_[1];r>=g&&r<=m&&(c+="<br />"+f.start+"-"+f.end)}}}else if(this.tissuesPosData[i])for(var v=0,y=Object.entries(this.tissuesPosData[i].regions);v<y.length;v++){var b=Object(s["a"])(y[v],2),x=b[0],w=b[1],C=x.split("_"),P=C[0],k=C[1];r>=P&&r<=k&&(c+=w)}""!=c?(l.innerHTML=c,l.setAttribute("class",""),l.style.left=a+15+"px",l.style.top=o+this.spaceBy+"px"):(l.innerHTML="",l.setAttribute("class","hidden"))},checkGEPosition:function(t){for(var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=Math.floor(e.clientY-n.top),i=document.querySelector("#GEInfoBox"),o="",l=-5;l<=5;l++)for(var c=-5;c<=5;c++)if(void 0!=this.GEPosData[a+l]&&void 0!=this.GEPosData[a+l][r+c])for(var u=0,d=Object.entries(this.GEPosData[a+l][r+c]);u<d.length;u++){var h=Object(s["a"])(d[u],2),p=h[0],f=h[1];o+="<span style='color:"+this.compareGroupColors[f.annotationIndex]+"'>"+p+"</span><br 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p=Object(s["a"])(h[d],2),f=p[0],_=p[1],g=f.split("_"),m=g[0],v=g[1];a>=m&&a<=v&&(u+="<br />"+_.start+"-"+_.end)}}}else if(a>=r.width-this.plotMargin.leftMargin/2&&a<=r.width)for(var y=Math.floor(o),b=y-4,x=y+4,w=b;w<=x;w++)if(this.annoPosData[w]&&this.annoPosData[w].annotation)for(var C=0,P=Object.entries(this.annoPosData[w].regions);C<P.length;C++){var k=Object(s["a"])(P[C],2),M=k[0],E=k[1],D=M.split("_"),O=D[0],L=D[1];a>=O&&a<=L&&(u+=E)}""==u?(c.innerHTML="",c.setAttribute("class","hidden")):(c.innerHTML=u,c.setAttribute("class",""),c.style.left=i+15+"px",c.style.top=o+this.spaceBy/2+"px")},getColorIndex:function(t){var e=Object.keys(this.annoData),n=e.indexOf(t);return this.compareGroupColors[n]},getGlobalEnrichment:function(){var t=this;return Object(o["a"])(h().mark((function e(){var n,r,a,i,o,c,u,d,p,f;return h().wrap((function(e){while(1)switch(e.prev=e.next){case 0:return n="KP BioIndex"==t.renderConfig["annotations server"]?t.utils.uiUtils.biDomain()+"/api/bio":t.renderConfig["annotations server"],r=t.searchingPhenotype,a=t.renderConfig["global enrichment index"]?t.renderConfig["global enrichment index"]:"global-enrichment",i=n+"/query/"+a+"?q="+r,e.next=6,fetch(i).then((function(t){return t.json()}));case 6:if(o=e.sent,null==o.error){for("newSearch"==t.dataComparison&&(t.GEData={}),t.GEData[t.searchingPhenotype]=o.data,c=0,u=Object.entries(t.GEData);c<u.length;c++)d=Object(s["a"])(u[c],2),d[0],p=d[1],p.map((function(e){var n=e.ancestry,r=e.annotation,a=e.pValue,i=e.phenotype,o=e.tissue;t.annoData[r]&&t.annoData[r][o]&&(t.annoData[r][o].ancestries[n]||(t.annoData[r][o].ancestries[n]={}),t.annoData[r][o].ancestries[n][i]=a),t.tissuesData[o]&&t.tissuesData[o][r]&&(t.tissuesData[o][r].ancestries[n]||(t.tissuesData[o][r].ancestries[n]={}),t.tissuesData[o][r].ancestries[n][i]=a)}));t.tissuesData=Object.fromEntries(Object.entries(t.tissuesData).sort()),f=t.getGEByTissue(),null!=t.pkgData&&(l["default"].set(t.pkgData,"GEByTissueData",f),l["default"].set(t.pkgData,"GEData",t.GEData),l["default"].set(t.pkgData,"annoData",t.annoData),l["default"].set(t.pkgData,"tissuesData",t.tissuesData)),t.renderByAnnotations(),t.renderGE()}t.$forceUpdate();case 9:case"end":return e.stop()}}),e)})))()},getGEByTissue:function(){for(var t=this,e={},n=function(){var n=Object(s["a"])(a[r],2),i=n[0],o=n[1];e[i]={},o.map((function(n){if(e[i][n.tissue]||(e[i][n.tissue]={}),e[i][n.tissue][n.annotation]||(e[i][n.tissue][n.annotation]={pValue:null,fold:null,gregor:null}),t.renderConfig.ancestry&&n.ancestry==t.renderConfig.ancestry){var r=e[i][n.tissue][n.annotation].pValue;(null==r||n.pValue<r)&&(e[i][n.tissue][n.annotation].pValue=t.utils.Formatters.pValueFormatter(n.pValue),e[i][n.tissue][n.annotation].fold=t.utils.Formatters.pValueFormatter(n.SNPs/n.expectedSNPs))}else{var a=e[i][n.tissue][n.annotation].pValue;(null==a||n.pValue<a)&&(e[i][n.tissue][n.annotation].pValue=t.utils.Formatters.pValueFormatter(n.pValue),e[i][n.tissue][n.annotation].fold=t.utils.Formatters.pValueFormatter(n.SNPs/n.expectedSNPs))}}))},r=0,a=Object.entries(this.GEData);r<a.length;r++)n();return e},getAnnotations:function(t){var e=this;return Object(o["a"])(h().mark((function n(){var r,a,i,o;return h().wrap((function(n){while(1)switch(n.prev=n.next){case 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n=Object(s["a"])(a[r],2),i=n[0],o=n[1];e[i]={xMax:null,xMin:null,yMax:null,yMin:null},o.map((function(n){if(t.annoData[n.annotation][n.tissue])if(e[i][n.annotation]||(e[i][n.annotation]={}),t.renderConfig.ancestry){if(n.ancestry==t.renderConfig.ancestry){var r=-Math.log10(n.pValue),a=n.SNPs/n.expectedSNPs;e[i].yMax=null==e[i].yMax||a>e[i].yMax?a:e[i].yMax,e[i].yMin=null==e[i].yMin||a<e[i].yMin?a:e[i].yMin,e[i].xMax=null==e[i].xMax||r>e[i].xMax?r:e[i].xMax,e[i].xMin=null==e[i].xMin||r<e[i].xMin?r:e[i].xMin,e[i][n.annotation][n.tissue]=e[i][n.annotation][n.tissue]?e[i][n.annotation][n.tissue]:{pValue:null,fold:null};var o=e[i][n.annotation][n.tissue].pValue,s=e[i][n.annotation][n.tissue].fold;e[i][n.annotation][n.tissue].pValue=null==o||r>o?r:o,e[i][n.annotation][n.tissue].fold=null==s||a>s?a:s}}else{var 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e=this;t&&"all"==t&&(this.GEData={},this.GEPosData={}),this.annoData={},this.tissuesData={},this.tissuesPosData={},this.selectedAnnos=[],this.selectedTissues=[],this.annoPosData={},this.annotationOnFocus="null",this.tissueOnFocus="null",this.pkgDataSelected.map((function(t){"Tissue"==t.type&&e.$store.dispatch("pkgDataSelected",{type:t.type,id:t.id,action:"remove"})})),this.getAnnotations(this.searchingRegion),this.renderByAnnotations()},getOverlappingRegion:function(){var t=this;if(this.renderConfig["overlapping regions"]&&"false"!=this.renderConfig["overlapping regions"]){var e={};if(this.pkgDataSelected.length>0&&this.pkgDataSelected.map((function(t){e[t.type]||(e[t.type]=[]),e[t.type].push(t.id)})),e["Tissue"]&&e["Tissue"].length>0&&e["Annotation"]&&e["Annotation"].length>0){var n={and:null,or:null};e["Annotation"].map((function(r){e["Tissue"].map((function(e){if(t.pkgData.annoData[r]&&t.pkgData.annoData[r][e])for(var a=function(){var a=Object(s["a"])(o[i],2),l=a[0],c=a[1],u=[];t.pkgData.annoData[r][e].region.map((function(t){for(var e=t.start;e<=t.end;e++)u.push(e)})),n[l]=null==c?u:"and"==l?t.getArraysIntersection(n[l],u):n[l].concat(u)},i=0,o=Object.entries(n);i<o.length;i++)a()}))}));for(var r=0,a=Object.entries(n);r<a.length;r++){var i=Object(s["a"])(a[r],2),o=i[0];i[1];n[o].sort((function(t,e){return t-e}))}for(var l={and:[],or:[]},u=0,d=Object.entries(l);u<d.length;u++)for(var h=Object(s["a"])(d[u],2),p=h[0],f=(h[1],0);f<n[p].length;f++)if(0==f||f==n[p].length-1)l[p].push(n[p][f]);else{var _=n[p][f-1]+1,g=n[p][f];g>_&&(l[p].push(n[p][f-1]),l[p].push(n[p][f]))}for(var m={and:[],or:[]},v=0,y=Object.entries(l);v<y.length;v++)for(var b=Object(s["a"])(y[v],2),x=b[0],w=(b[1],0);w<l[x].length-1;w+=2){var C={};C["start"]=l[x][w],C["end"]=l[x][w+1],m[x].push(C)}c["default"].set(this.pkgData,"overlappingRegions",m)}else delete this.pkgData["overlappingRegions"]}},getArraysIntersection:function(t,e){return t.filter((function(t){return-1!==e.indexOf(t)}))},onMouseOut:function(t){this.utils.uiUtils.removeOnMouseOut(t,1e3)},onResize:function(t){this.utils.uiUtils.showElement("annotationsPlotWrapper"),this.renderByAnnotations(),this.renderGE()},addAnnoTrack:function(t){if("null"!=t.target.value){var e=this.pkgDataSelected.filter((function(t){return"Annotation"==t.type})).map((function(t){return t.id}));e.indexOf(t.target.value)<0&&(e.push(t.target.value),null!=this.pkgData&&(this.$store.dispatch("pkgDataSelected",{type:"Annotation",id:t.target.value,action:"add"}),c["default"].set(this.pkgData,"selectedAnnos",e)))}this.renderGE()},removeAnnoTrack:function(t){var e=this.pkgDataSelected.filter((function(t){return"Annotation"==t.type})).map((function(t){return t.id})),n=e.indexOf(t);n>-1&&(e.splice(n,1),null!=this.pkgData&&(this.$store.dispatch("pkgDataSelected",{type:"Annotation",id:t,action:"remove"}),c["default"].set(this.pkgData,"selectedAnnos",e)),this.renderGE())},addRemoveTissueTrack:function(t){var e=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id})),n=e.indexOf(t);n>-1?null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:t,action:"remove"}):null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:t,action:"add"})},removeTissueTrack:function(t){var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=(e.clientX,n.left,Math.ceil(Math.floor(e.clientY-n.top)/this.spaceBy)),i=this.pkgDataSelected.filter((function(t){return"Tissue"==t.type})).map((function(t){return t.id}));if(r>

1n.width-this.plotMargin.leftMargin&&this.tissuesPosData[a])for(var o=0,l=Object.entries(this.tissuesPosData[a].regions);o<l.length;o++){var c=Object(s["a"])(l[o],2),u=c[0],d=(c[1],u.split("_")),h=d[0],p=d[1];if(r>=h&&r<=p){var f=this.tissuesPosData[a].tissue,_=i.indexOf(f);_>-1&&null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:f,action:"remove"})}}},checkGEPosition:function(t){for(var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=Math.floor(e.clientY-n.top),i=document.querySelector("#GEInfoBox"),o="",l=-5;l<=5;l++)for(var c=-5;c<=5;c++)if(void 0!=this.GEPosData[a+l]&&void 0!=this.GEPosData[a+l][r+c])for(var u=0,d=Object.entries(this.GEPosData[a+l][r+c]);u<d.length;u++){var h=Object(s["a"])(d[u],2),p=h[0],f=h[1];o+="<span style='color:"+this.compareGroupColors[f.annotationIndex]+"'>"+p+"</span><br />"}""!=o?(i.innerHTML=o,i.setAttribute("class",""),r<.75*n.width?(i.style.width="auto",i.style.left=r+15+"px",i.style.top=a+this.spaceBy+"px"):(i.style.width="200px",i.style.left=r-215+"px",i.style.top=a+this.spaceBy+"px")):i.setAttribute("class","hidden")},checkPosition:function(t,e){var n=t,r=n.target.getBoundingClientRect(),a=Math.floor(n.clientX-r.left),i=n.clientX-r.left,o=n.clientY-r.top,l=Math.round(this.spaceBy/2),c=Math.ceil(Math.floor(n.clientY-r.top)/l)-1,u=document.querySelector("#tissueInfoBox"),d="";if("hover"==e)if(a>=this.plotMargin.leftMargin/2&&a<=r.width){if(this.annoPosData[c]){d+=this.annoPosData[c].tissue;for(var h=0,p=Object.entries(this.annoPosData[c].regions);h<p.length;h++){var f=Object(s["a"])(p[h],2),_=f[0],g=f[1],m=_.split("_"),v=m[0],y=m[1];a>=v&&a<=y&&(d+="<br />"+g.start+"-"+g.end+"<br />State: "+g.state)}}}else if(a>=r.width-this.plotMargin.leftMargin&&a<=r.width)for(var b=Math.floor(o),x=b-4,w=b+4,C=x;C<=w;C++)if(this.annoPosData[C]&&this.annoPosData[C].annotation)for(var P=0,k=Object.entries(this.annoPosData[C].regions);P<k.length;P++){var M=Object(s["a"])(k[P],2),E=M[0],D=M[1],O=E.split("_"),L=O[0],j=O[1];a>=L&&a<=j&&(d+=D)}"click"==e&&a>=this.plotMargin.leftMargin/2&&a<=r.width&&this.annoPosData[c]&&(d+=this.annoPosData[c].tissue),"hover"==e&&(""==d?(u.innerHTML="",u.setAttribute("class","hidden")):(u.innerHTML=d,u.setAttribute("class",""),u.style.left=i+15+"px",u.style.top=o+l+"px")),"click"==e&&""!=d&&this.addRemoveTissueTrack(d)},getColorIndex:function(t){var e=Object.keys(this.annoData),n=e.indexOf(t);return this.compareGroupColors[n]},getGlobalEnrichment:function(){var t=this;return Object(o["a"])(p().mark((function e(){var n,r,a,i,o,l,u,d,h,f;return p().wrap((function(e){while(1)switch(e.prev=e.next){case 0:return n="KP BioIndex"==t.renderConfig["annotations server"]?t.utils.uiUtils.biDomain()+"/api/bio":t.renderConfig["annotations server"],r=t.searchingPhenotype,a=t.renderConfig["global enrichment index"]?t.renderConfig["global enrichment index"]:"global-enrichment",i=n+"/query/"+a+"?q="+r,e.next=6,fetch(i).then((function(t){return t.json()}));case 6:if(o=e.sent,null==o.error){for("newSearch"==t.dataComparison&&(t.GEData={}),t.GEData[t.searchingPhenotype]=o.data,l=0,u=Object.entries(t.GEData);l<u.length;l++)d=Object(s["a"])(u[l],2),d[0],h=d[1],h.map((function(e){var n=e.ancestry,r=e.annotation,a=e.pValue,i=e.phenotype,o=e.tissue;t.annoData[r]&&t.annoData[r][o]&&(t.annoData[r][o].ancestries[n]||(t.annoData[r][o].ancestries[n]={}),t.annoData[r][o].ancestries[n][i]=a),t.tissuesData[o]&&t.tissuesData[o][r]&&(t.tissuesData[o][r].ancestries[n]||(t.tissuesData[o][r].ancestries[n]={}),t.tissuesData[o][r].ancestries[n][i]=a)}));t.tissuesData=Object.fromEntries(Object.entries(t.tissuesData).sort()),f=t.getGEByTissue(),null!=t.pkgData&&(c["default"].set(t.pkgData,"GEByTissueData",f),c["default"].set(t.pkgData,"GEData",t.GEData),c["default"].set(t.pkgData,"annoData",t.annoData),c["default"].set(t.pkgData,"tissuesData",t.tissuesData)),t.renderByAnnotations(),t.renderGE()}t.$forceUpdate();case 9:case"end":return e.stop()}}),e)})))()},getGEByTissue:function(){var t=this,e={};Object.keys(this.GEData).map((function(n){e[n]={},Object.keys(t.annoData).map((function(t){e[n][t]={}}))}

1));for(var n={},r=function(){var r=Object(s["a"])(i[a],2),o=r[0],l=r[1];n[o]={},l&&l.map((function(r){n[o][r.tissue]||(n[o][r.tissue]={}),n[o][r.tissue][r.annotation]||(n[o][r.tissue][r.annotation]={pValue:null,fold:null,gregor:null,rank:null,ancestries:{}});var a=n[o][r.tissue][r.annotation];a.ancestries[r.ancestry]||(a.ancestries[r.ancestry]={fold:null,pValue:null,rank:null}),a.ancestries[r.ancestry].pValue=t.utils.Formatters.pValueFormatter(r.pValue),a.ancestries[r.ancestry].fold=t.utils.Formatters.pValueFormatter(r.SNPs/r.expectedSNPs);var i=n[o][r.tissue][r.annotation].pValue;(null==i||r.pValue<i)&&(n[o][r.tissue][r.annotation].pValue=t.utils.Formatters.pValueFormatter(r.pValue),n[o][r.tissue][r.annotation].fold=t.utils.Formatters.pValueFormatter(r.SNPs/r.expectedSNPs)),e[o]&&e[o][r.annotation]&&!e[o][r.annotation][r.ancestry]&&(e[o][r.annotation][r.ancestry]=[]),e[o]&&e[o][r.annotation]&&e[o][r.annotation][r.ancestry].push({tissue:r.tissue,fold:a.ancestries[r.ancestry].fold})}))},a=0,i=Object.entries(this.GEData);a<i.length;a++)r();return Object.keys(e).map((function(r){Object.keys(e[r]).map((function(a){Object.keys(e[r][a]).map((function(i){e[r][a][i]=Object(l["a"])(new Map(e[r][a][i].map((function(t){return[t["tissue"],t]}))).values()),e[r][a][i].sort((function(t,e){return e.fold-t.fold}));var o=0;e[r][a][i].map((function(e){t.tissuesData[e.tissue]&&t.tissuesData[e.tissue][a]&&(n[r][e.tissue][a].ancestries[i].rank=o,o++)}))}))}))})),n},getAnnotations:function(t){var e=this;return Object(o["a"])(p().mark((function n(){var r,a,i,o;return p().wrap((function(n){while(1)switch(n.prev=n.next){case 0:if(!(t&&t.chr&&t.start&&t.end)){n.next=8;break}return r="KP BioIndex"==e.renderConfig["annotations server"]?e.utils.uiUtils.biDomain()+"/api/bio":e.renderConfig["annotations server"],a=e.renderConfig["annotations index"]?e.renderConfig["annotations index"]:"regions",i=r+"/query/"+a+"?q="+t.chr+":"+t.start+"-"+t.end,n.next=6,fetch(i).then((function(t){return t.json()}));case 6:o=n.sent,null==o.error&&(null==o.continuation?e.runAfterAnnoDataLoad(o):e.loadContinue(o));case 8:case"end":return n.stop()}}),n)})))()},loadContinue:function(t){var e=this;return Object(o["a"])(p().mark((function n(){var r,a,i,o,s;return p().wrap((function(n){while(1)switch(n.prev=n.next){case 0:return r="KP BioIndex"==e.renderConfig["annotations server"]?e.utils.uiUtils.biDomain()+"/api/bio":e.renderConfig["annotations server"],a=r+"/cont?token="+t.continuation,n.next=4,fetch(a).then((function(t){return t.json()}));case 4:i=n.sent,null==i.error&&(o=t.data,s=o.concat(i.data),i.data=s,null==i.continuation?e.runAfterAnnoDataLoad(i):e.loadContinue(i));case 6:case"end":return n.stop()}}),n)})))()},runAfterAnnoDataLoad:function(t){var e=this;this.annoData={},this.tissuesData={},t.data.map((function(t){e.annoData[t.annotation]||(e.annoData[t.annotation]={}),e.annoData[t.annotation][t.tissue]||(e.annoData[t.annotation][t.tissue]={region:[],ancestries:{}}),e.annoData[t.annotation][t.tissue].region.push(t),e.tissuesData[t.tissue]||(e.tissuesData[t.tissue]={}),e.tissuesData[t.tissue][t.annotation]||(e.tissuesData[t.tissue][t.annotation]={region:[],ancestries:{}}),e.tissuesData[t.tissue][t.annotation].region.push(t)})),null!=this.pkgData&&(c["default"].set(this.pkgData,"annoData",this.annoData),c["default"].set(this.pkgData,"tissuesData",this.tissuesData)),this.getGlobalEnrichment()},renderGE:function(){var t=this;this.GEPosData={};var e={},n=[],r=this.renderConfig["phenotype parameter"],a=this.renderConfig["ancestry parameter"],i=0;this.searchParameters[r].search.map((function(e){n[i]={},n[i]["phenotype"]=e,n[i]["ancestry"]=a?t.searchParameters[a].search[i]:"Mixed",i++})),n.map((function(n){var r=t.renderConfig["phenotype match"]?t.renderConfig["phenotype match"][n.phenotype]:n.phenotype,a=n.ancestry,i=t.GEData[r];e[r]||(e[r]={}),e[r][a]={xMax:null,xMin:null,yMax:null,yMin:null},i&&i.map((function(n){if(n.ancestry==a){var i=null;if((a&&t.annoData[n.annotation][n.tissue]&&t.annoData[n.annotation][n.tissue]["ancestries"][a]||!a&&t.annoData[n.annotation][n.tissue]&&t.annoData[n.annotation][n.tissue])&&(i=!0),i){e[r][a][n.annotation]||(e[r][a][n.annotation]={});var o=a?t.annoData[n.annotation][n.tissue]["ancestries"][a][r]:n.pValue;o=0==o?324:-Math.log10(o);var s=n.SNPs/n.expectedSNPs;e[r][a].yMax=null==e[r][a].yMax||s>e[r][a].yMax?s:e[r][a].yMax,e[r][a].yMin=null==e[r][a].yMin||s<e[r][a].yMin?s:e[r][a].yMin,e[r][a].xMax=null==e[r][a].xMax||o>e[r][a].xMax?o:e[r][a].xMax,e[r][a].xMin=null==e[r][a].xMin||o<e[r][a].xMin?o:e[r][a].xMin,e[r][a][n.annotation][n.tissue]=e[r][a][n.annotation][n.tissue]?e[r][a][n.annotation][n.tissue]:{pValue:null,fold:null};var l=e[r][a][n.annotation][n.tissue].pValue,c=e[r][a][n.annotation][n.tissue].fold;e[r][a][n.annotation][n.tissue].pValue=null==l||o>l?o:l,e[r][a][n.annotation][n.tissue].fold=null==c||s>c?s:c}}}))}));var o=0;Object.keys(e).map((function(t){o+=Object.keys(e[t]).length}));var l,c,u=2*document.querySelector("#GEPlotWrapper").clientWidth*.25,d=u*o,h=260,p=2*this.spaceBy,f=this.plotMargin.topMargin+this.plotMargin.bottomMargin+h+p,_=u-this.plotMargin.leftMargin-this.plotMargin.rightMargin,g=11;l=document.querySelector("#GEPlot"),l.setAttribute("width",d),l.setAttribute("height",f),l.setAttribute("style","width:"+d/2+"px;

1height:"+f/2+"px;"),c=l.getContext("2d");var m=0;n.map((function(n){var r=t.renderConfig["phenotype match"]?t.renderConfig["phenotype match"][n.phenotype]:n.phenotype,a=n.ancestry,i=e[r][a],o=p,l=g+u*m,d=r+"("+a+")";c.font="28px Arial",c.textAlign="left",c.fillStyle="#000000",c.fillText(d,l,o),t.renderGEAxis(c,_,h,i.xMax,i.xMin,i.yMax,i.yMin,l,o,g);var f=Object.keys(t.annoData),v=[],y=[];f.map((function(t){if(i[t])for(var e=0,n=Object.entries(i[t]);e<n.length;e++){var r=Object(s["a"])(n[e],2),a=(r[0],r[1]);y.push(a.pValue),v.push(a.fold)}})),v.sort((function(t,e){return e-t})),y.sort((function(t,e){return e-t}));var b=_/(i.xMax-i.xMin),x=h/(i.yMax-i.yMin);f.map((function(e,n){var r="null"==t.annotationOnFocus||e==t.annotationOnFocus?t.compareGroupColors[n]:"#00000030";if(i[e])for(var a=0,d=Object.entries(i[e]);a<d.length;a++){var p=Object(s["a"])(d[a],2),f=p[0],_=p[1],g=l+t.plotMargin.leftMargin+(_.pValue-i.xMin)*b,m=o+t.plotMargin.topMargin+h-(_.fold-i.yMin)*x;c.fillStyle=r,c.lineWidth=0,c.beginPath(),c.arc(g,m,8,0,2*Math.PI),c.fill(),(_.fold>=v[2]||_.pValue>=y[2])&&(c.font="24px Arial",c.fillStyle=t.pkgData.selectedAnnos&&0!=t.pkgData.selectedAnnos.length?t.pkgData.selectedAnnos&&t.pkgData.selectedAnnos.includes(e)?"#000000":"#00000050":"#000000",g>.75*u?(c.textAlign="right",c.fillText(f,g-14,m+6)):(c.textAlign="left",c.fillText(f,g+14,m+6))),t.GEPosData[Math.round(m/2)]||(t.GEPosData[Math.round(m/2)]={}),t.GEPosData[Math.round(m/2)][Math.round(g/2)]||(t.GEPosData[Math.round(m/2)][Math.round(g/2)]={}),t.GEPosData[Math.round(m/2)][Math.round(g/2)][f]={pValue:null,fold:null},t.GEPosData[Math.round(m/2)][Math.round(g/2)][f]["pValue"]=_.pValue,t.GEPosData[Math.round(m/2)][Math.round(g/2)][f]["fold"]=_.fold,t.GEPosData[Math.round(m/2)][Math.round(g/2)][f]["annotationIndex"]=n}})),m++}))},renderGEAxis:function(t,e,n,r,a,i,o,s,l,c){t.beginPath(),t.lineWidth=1,t.strokeStyle="#000000",t.setLineDash([]);var u=Math.round(s+this.plotMargin.leftMargin-c);t.moveTo(u,l+this.plotMargin.topMargin),t.lineTo(u,l+this.plotMargin.topMargin+n+c);for(var 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C=s+this.plotMargin.leftMargin+w*x,P=Math.floor(C);t.moveTo(P,l+n+this.plotMargin.topMargin+c),t.lineTo(P,l+n+this.plotMargin.topMargin+2*c),t.stroke(),t.textAlign="center",t.font="24px Arial";var k=r-a,M=k<=1?2:k<=50?1:0,E=this.utils.Formatters.decimalFormatter(a+w*b,M);E=E>=1e5?Math.round(.001*E)+"k":E,t.fillText(E,P,l+n+this.plotMargin.topMargin+4*c)}var D=this.renderConfig["global enrichment x axis label"]?this.renderConfig["global enrichment x axis label"]:"-Log10(p-value)";t.textAlign="center",t.fillText(D,s+this.plotMargin.leftMargin+e/2,l+n+6*c+this.plotMargin.topMargin+24)},array2Object:function(t,e){var n={};return e.map((function(e){var r=e[t];n[r]=e})),n},renderByAnnotations:function(){var t=this;if(this.pkgData.GEByTissueData){var e=this.getGEByTissue(),n=[],r=this.renderConfig["phenotype parameter"],a=this.renderConfig["ancestry 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1)),r=[];if(n.map((function(t){r.push(t.id)})),r.length>0){var a=[],i=[];r.map((function(t){var n=t.split(" / "),r=n[0],o=n[1],s=n[2];e.pkgData.biosamplesData&&e.pkgData.biosamplesData[r]&&e.pkgData.biosamplesData[r][o]&&e.pkgData.biosamplesData[r][o][s]&&e.pkgData.biosamplesData[r][o][s].map((function(t){a.push(t.method),i.push(t.source)}))})),a=Object(l["a"])(new Set(a)),i=Object(l["a"])(new Set(i));var o={methods:a,sources:i};return o[t]}return null},addRemoveParameter:function(t,e){this.pkgDataSelected.filter((function(n){return n.id==t&&n.type==e})).length>0?this.$store.dispatch("pkgDataSelected",{type:e,id:t,action:"remove"}):this.$store.dispatch("pkgDataSelected",{type:e,id:t,action:"add"})},getOverlappingBSRegion:function(){var t=this;if(this.renderConfig["overlapping regions"]&&"false"!=this.renderConfig["overlapping regions"]){var e=this.$store.state.pkgDataSelected.filter((function(t){return"BS-Method"==t.type})).map((function(t){return t.id})),n=this.$store.state.pkgDataSelected.filter((function(t){return"BS-Source"==t.type})).map((function(t){return t.id})),r={};if(this.pkgDataSelected.length>0&&this.pkgDataSelected.map((function(t){r[t.type]||(r[t.type]=[]),r[t.type].push(t.id)})),r["Biosample"]){var a={and:null,or:null};r["Biosample"].map((function(r){for(var i=r.split(" / "),o=i[0],l=i[1],c=i[2],u=function(){var r=Object(s["a"])(h[d],2),i=r[0],u=r[1],p=[];t.pkgData.biosamplesData&&t.pkgData.biosamplesData[o]&&t.pkgData.biosamplesData[o][l]&&t.pkgData.biosamplesData[o][l][c]&&t.pkgData.biosamplesData[o][l][c].map((function(t){if(-1==e.indexOf(t.method)&&-1==n.indexOf(t.source))for(var r=t.start;r<=t.end;r++)p.push(r)})),a[i]=null==u?p:"and"==i?t.getArraysIntersection(a[i],p):a[i].concat(p)},d=0,h=Object.entries(a);d<h.length;d++)u()}));for(var i=0,o=Object.entries(a);i<o.length;i++){var l=Object(s["a"])(o[i],2),u=l[0];l[1];a[u].sort((function(t,e){return t-e}))}for(var d={and:[],or:[]},h=0,p=Object.entries(d);h<p.length;h++)for(var f=Object(s["a"])(p[h],2),_=f[0],g=(f[1],0);g<a[_].length;g++)if(0==g||g==a[_].length-1)d[_].push(a[_][g]);else{var m=a[_][g-1]+1,v=a[_][g];v>m&&(d[_].push(a[_][g-1]),d[_].push(a[_][g]))}for(var y={and:[],or:[]},b=0,x=Object.entries(d);b<x.length;b++)for(var w=Object(s["a"])(x[b],2),C=w[0],P=(w[1],0);P<d[C].length-1;P+=2){var k={};k["start"]=d[C][P],k["end"]=d[C][P+1],y[C].push(k)}c["default"].set(this.pkgData,"overlappingBiosampleRegions",y)}else this.pkgData["overlappingBiosampleRegions"]&&delete this.pkgData["overlappingBiosampleRegions"]}},getArraysIntersection:function(t,e){return t.filter((function(t){return-1!==e.indexOf(t)}))},onMouseOut:function(t){this.utils.uiUtils.removeOnMouseOut(t,1e3)},onResize:function(t){this.utils.uiUtils.showElement("biosamplesPlotWrapper"),this.renderBiosamplesTrack("on resize"),this.renderConfig["with annotations viewer"]&&"false"!=this.renderConfig["with annotations viewer"]||this.renderGE()},removeAnno:function(t){this.$store.dispatch("pkgDataSelected",{type:"Annotation",id:t,action:"remove"})},removeTissue:function(t){this.$store.dispatch("pkgDataSelected",{type:"Tissue",id:t,action:"remove"})},addRemoveBiosampleTrack:function(t){var e=this.pkgDataSelected.filter((function(t){return"Biosample"==t.type})).map((function(t){return t.id})),n=e.indexOf(t);n>-1?null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Biosample",id:t,action:"remove"}):null!=this.pkgData&&this.$store.dispatch("pkgDataSelected",{type:"Biosample",id:t,action:"add"})},checkGEPosition:function(t){for(var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=Math.floor(e.clientY-n.top),i=Math.round(this.spaceBy/2),o=document.querySelector("#BSGEInfoBox"),l="",c=-5;c<=5;c++)for(var u=-5;u<=5;u++)if(void 0!=this.GEPosData[a+c]&&void 0!=this.GEPosData[a+c][r+u])for(var d=0,h=Object.entries(this.GEPosData[a+c][r+u]);d<h.length;d++){var p=Object(s["a"])(h[d],2),f=p[0],_=p[1];l+="<span style='color:"+this.compareGroupColors[_.annotationIndex]+"'>"+f+"</span><br />"}""!=l?(o.innerHTML=l,o.setAttribute("class",""),r<.75*n.width?(o.style.width="auto",o.style.left=r+15+"px",o.style.top=a+i+"px"):(o.style.width="200px",o.style.left=r-215+"px",o.style.top=a+i+"px")):o.setAttribute("class","hidden")},checkPosition:function(t,e){var n=t,r=n.target.getBoundingClientRect(),a=Math.floor(n.clientX-r.left),i=n.clientX-r.left,o=n.clientY-r.top,l=Math.round(this.spaceBy/2),c=Math.ceil(Math.floor(n.clientY-r.top)/l)-1,u=document.querySelector("#biosampleInfoBox"),d="";if("hover"==e)if(a>=this.plotMargin.leftMargin/2&&a<=r.width-this.plotMargin.leftMargin/2){if(this.bi

1osamplesPosData[c]){d+=this.biosamplesPosData[c].biosample;for(var h=0,p=Object.entries(this.biosamplesPosData[c].regions);h<p.length;h++){var f=Object(s["a"])(p[h],2),_=f[0],g=f[1],m=_.split("_"),v=m[0],y=m[1];a>=v&&a<=y&&(d+="<br />"+g.start+"-"+g.end+"<br />dataset: "+g.dataset+"<br />source: "+g.source+"<br />method: "+g.method+"<br />state: "+g.state+"<br />")}}}else if(a>=r.width-this.plotMargin.leftMargin/2&&a<=r.width)for(var b=Math.floor(o),x=b-8,w=b+8,C=x;C<=w;C++)if(this.biosamplesPosData[C]&&this.biosamplesPosData[C].annotation)for(var P=0,k=Object.entries(this.biosamplesPosData[C].regions);P<k.length;P++){var M=Object(s["a"])(k[P],2),E=M[0],D=M[1],O=E.split("_"),L=O[0],j=O[1];a>=L&&a<=j&&(d+=D)}"click"==e&&a>=this.plotMargin.leftMargin/2&&a<=r.width-this.plotMargin.leftMargin/2&&this.biosamplesPosData[c]&&(d+=this.biosamplesPosData[c].annotation+" / "+this.biosamplesPosData[c].tissue+" / "+this.biosamplesPosData[c].biosample),"hover"==e&&(""==d?(u.innerHTML="",u.setAttribute("class","hidden")):(u.innerHTML=d,u.setAttribute("class",""),u.style.left=i+15+"px",u.style.top=o+l+"px")),"click"==e&&""!=d&&this.addRemoveBiosampleTrack(d)},getColorIndex:function(t){var e=Object.keys(this.pkgData.annoData),n=e.indexOf(t);return this.compareGroupColors[n]},getGlobalEnrichment:function(){var t=this;return Object(o["a"])(p().mark((function e(){var n,r,a,i,o,l,u,d,h,f;return p().wrap((function(e){while(1)switch(e.prev=e.next){case 0:return n="KP BioIndex"==t.renderConfig["biosamples server"]?t.utils.uiUtils.biDomain()+"/api/bio":t.renderConfig["biosamples server"],r=t.searchingPhenotype,a=t.renderConfig["global enrichment index"]?t.renderConfig["global enrichment index"]:"global-enrichment",i=n+"/query/"+a+"?q="+r,e.next=6,fetch(i).then((function(t){return t.json()}));case 6:if(o=e.sent,null==o.error){for("newSearch"==t.searchType&&(t.GEData={}),t.GEData[t.searchingPhenotype]=o.data,l=0,u=Object.entries(t.GEData);l<u.length;l++)d=Object(s["a"])(u[l],2),d[0],h=d[1],h.map((function(e){var n=e.ancestry,r=e.annotation,a=e.pValue,i=e.phenotype,o=e.tissue;t.annoData[r]&&t.annoData[r][o]&&(t.annoData[r][o].ancestries[n]||(t.annoData[r][o].ancestries[n]={}),t.annoData[r][o].ancestries[n][i]=a),t.tissuesData[o]&&t.tissuesData[o][r]&&(t.tissuesData[o][r].ancestries[n]||(t.tissuesData[o][r].ancestries[n]={}),t.tissuesData[o][r].ancestries[n][i]=a)}));t.tissuesData=Object.fromEntries(Object.entries(t.tissuesData).sort()),f=t.getGEByTissue(),null!=t.pkgData&&(c["default"].set(t.pkgData,"GEByTissueData",f),c["default"].set(t.pkgData,"GEData",t.GEData),c["default"].set(t.pkgData,"annoData",t.annoData),c["default"].set(t.pkgData,"tissuesData",t.tissuesData)),t.renderGE(),t.renderBiosamplesTrack()}t.$forceUpdate();case 9:case"end":return e.stop()}}),e)})))()},getGEByTissue:function(){var t=this,e={};Object.keys(this.GEData).map((function(n){e[n]={},Object.keys(t.annoData).map((function(t){e[n][t]=[]}))}));for(var n={},r=function(){var r=Object(s["a"])(i[a],2),o=r[0],l=r[1];n[o]={},l.map((function(r){n[o][r.tissue]||(n[o][r.tissue]={}),n[o][r.tissue][r.annotation]||(n[o][r.tissue][r.annotation]={pValue:null,fold:null,gregor:null,rank:null});var a=n[o][r.tissue][r.annotation].pValue;(null==a||r.pValue<a)&&(n[o][r.tissue][r.annotation].pValue=t.utils.Formatters.pValueFormatter(r.pValue),n[o][r.tissue][r.annotation].fold=t.utils.Formatters.pValueFormatter(r.SNPs/r.expectedSNPs)),e[o][r.annotation]&&e[o][r.annotation].push({tissue:r.tissue,fold:n[o][r.tissue][r.annotation].fold})}))},a=0,i=Object.entries(this.GEData);a<i.length;a++)r();return Object.keys(e).map((function(r){Object.keys(e[r]).map((function(a){e[r][a]=Object(l["a"])(new Map(e[r][a].map((function(t){return[t["tissue"],t]}))).values()),e[r][a].sort((function(t,e){return e.fold-t.fold}));var i=0;e[r][a].map((function(e){t.tissuesData[e.tissue]&&t.tissuesData[e.tissue][a]&&(n[r][e.tissue][a].rank=i,i++)}))}))})),n},getBiosamples:function(t,e){var n=this;return Object(o["a"])(p().mark((function r(){var a,i,o,s,l,c,u,d;return p().wrap((function(r){while(1)switch(r.prev=r.next){case 0:if(a=n.getSelectedParameters("Annotation").sort(),i=n.getSelectedParameters("Tissue").sort(),a.includes(t)||n.$store.dispatch("pkgDataSelected",{type:"Annotation",id:t,action:"add"}),i.includes(e)||n.$store.dispatch("pkgDataSelected",{type:"Tissue",id:e,action:"add"}),!n.biosamplesData[t]||!n.biosamplesData[t][e]){r.next=8;break}n.renderBiosamplesTrack("after bs data load"),r.next=17;break;case 8:return o="KP BioIndex"==n.renderConfig["biosamples server"]?n.utils.uiUtils.biDomain()+"/api/bio":n.renderConfig["biosamples server"],s=n.renderConfig["biosamples index"]?n.renderConfig["biosamples index"]:"tissue-regions",l=e,c=n.searchingRegion,u=o+"/query/"+s+"?q="+l+","+c.chr+":"+c.start+"-"+c.end,r.next=15,fetch(u).then((function(t){return t.json()}));case 15:d=r.sent,null==d.error&&(null==d.continuation?n.runAfterBSDataLoad(d,t,e):n.loadContinue(d,t,e));case 17:case"end":return r.stop()}}),r)})))()},loadContinue:function(t,e,n){var r=this;return Object(o["a"])(p().mark((function a(){var i,o,s,l,c;return p().wrap((function(a){while(1)switch(a.prev=a.next){case 0:return i="KP BioIndex"==r.renderConfig["biosamples server"]?r.utils.uiUtils.biDomain()+"/api/bio":r.renderConfig["biosamples server"],o=i+"/cont?token="+t.continuation,a.next=4,fetch(o).then((function(t){return t.json()}));case 4:s=a.sent,null==s.error&&(l=t.data,c=l.concat(s.data),s.data=c,null==s.continuation?r.runAfterBSDataLoad(s,e,n):r.loadContinue(s,e,n));case 6:case"end":return a.stop()}}),a)})))()},runAfterBSDataLoad:function(t,e,n){var r=this,a=[];if(t.data.map((function(t){t.annotation==e&&a.push(t)})),a.length>0){var i=Object(l["a"])(new Set(a.map((function(t){return t.biosample})))).sort(Intl.Collator().compare);

1this.biosamplesData[e]||(this.biosamplesData[e]={}),this.biosamplesData[e][n]||(this.biosamplesData[e][n]={}),i.map((function(t){r.biosamplesData[e][n][t]||(r.biosamplesData[e][n][t]=[]),a.map((function(a){a.biosample==t&&r.biosamplesData[e][n][a.biosample].push(a)}))}))}null!=this.pkgData&&c["default"].set(this.pkgData,"biosamplesData",this.biosamplesData),this.renderBiosamplesTrack("after bs data load")},renderBiosamplesTrack:function(t){var e=this;this.biosamplesPosData={};var n=[];if(this.renderConfig["star key"]){var r=Array.isArray(this.plotData)?this.array2Object(this.renderConfig["star key"]["key"],this.plotData):this.plotData,a=this.renderConfig["star key"]["key"],i=this.renderConfig["star key"]["position"];this.pkgDataSelected.filter((function(t){return t.type==a})).map((function(t){return t.id})).map((function(t){n.push(r[t][i])}))}var o=0,l=2*this.spaceBy,c=7*this.spaceBy,u=this.spaceBy,d=2*this.spaceBy,h=2*this.spaceBy,p=this.viewingRegion.start,f=this.viewingRegion.end,_=this.pkgDataSelected.filter((function(t){return"Biosample"==t.type})).map((function(t){return t.id})),g=[],m=this.getSelectedParameters("Annotation").sort(),v=this.getSelectedParameters("Tissue").sort();m.map((function(t){v.map((function(n){g.push(t+" / "+n),o+=l,o+=Object.keys(e.biosamplesData[t][n]).length*u,o+=c}))}));var y=document.querySelector("#biosamplesPlotWrapper"),b=document.querySelector("#biosamplesPlot");if(b&&y){var x,w,C=2*y.clientWidth,P=o+d+h,k=C-2*this.plotMargin.leftMargin,M=11,E=k/(f-p);x=b,x.setAttribute("width",C),x.setAttribute("height",P),x.setAttribute("style","width:"+C/2+"px;height:"+P/2+"px;"),w=x.getContext("2d"),w.clearRect(0,0,C,P);var D=l;g.map((function(t){w.font="28px Arial",w.textAlign="left",w.fillStyle="#000000",w.fillText(t,M,D),D+=l;var r=t.split(" / 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1h((function(t){t.classList.remove("hidden")})),r=null,a=0;case 4:if(!(a<t.plotsList.length)){e.next=11;break}if("Combined"==t.plotsList[a]||null!=t.ldData[t.plotsList[a]].data){e.next=8;break}return r=t.plotsList[a],e.abrupt("break",11);case 8:a++,e.next=4;break;case 11:if(null==r){e.next=19;break}return i="https://portaldev.sph.umich.edu/ld/genome_builds/GRCh37/references/1000G/populations/"+t.ldData[r].population+"/variants?correlation=rsquare&variant="+t.ldData[r].refVariant+"&chrom="+t.searchingRegion.chr+"&start="+t.searchingRegion.start+"&stop="+t.searchingRegion.end+"&limit=100000",e.next=15,fetch(i).then((function(t){return t.json()}));case 15:o=e.sent,null==o.error&&(s={},o.data.variant2.map((function(t,e){s[t]=o.data.correlation[e]})),t.ldData[r].data=s,t.callForLDData()),e.next=30;break;case 19:l=p().mark((function e(){var n;return p().wrap((function(e){while(1)switch(e.prev=e.next){case 0:if("Combined"==t.plotsList[c]){e.next=4;break}return n=t.plotsList[c],Object.keys(t.plotData).map((function(e){t.plotData[e]["LDS"]=t.plotData[e]["LDS"]?t.plotData[e]["LDS"]:{},t.plotData[e]["LDS"][n]=t.ldData[n].data[e]})),e.abrupt("return",1);case 4:case"end":return e.stop()}}),e)})),c=0;case 21:if(!(c<t.plotsList.length)){e.next=28;break}return e.delegateYield(l(),"t0",23);case 23:if(!e.t0){e.next=25;break}return e.abrupt("break",28);case 25:c++,e.next=21;break;case 28:t.isSectionPage||t.$store.dispatch("filteredData",t.plotData),t.renderPlots();case 30:t.$forceUpdate();case 31:case"end":return e.stop()}}),e)})))()},renderPlots:function(t){var e=this,n=this.searchingRegion.start,r=this.searchingRegion.end,a=.75*document.querySelector("#rp_region_plot").clientWidth*2-60,i=.25*document.querySelector("#rp_region_plot").clientWidth*2-60,o=this.renderConfig.height?2*this.renderConfig.height+this.adjPlotMargin.top+this.adjPlotMargin.bottom:600+this.adjPlotMargin.top+this.adjPlotMargin.bottom,s=a-2*this.adjPlotMargin.left,l=i-this.adjPlotMargin.left-this.adjPlotMargin.right,c=this.renderConfig.height?2*this.renderConfig.height:600,u=this.adjPlotMargin.bump;this.plotsList.map((function(t){var d,h;d=document.getElementById("asso_plot_"+t.replaceAll(" ","_")+e.sectionId),d.setAttribute("width",a),d.setAttribute("height",o),d.setAttribute("style","width:"+a/2+"px;height:"+o/2+"px;"),h=d.getContext("2d"),h.clearRect(0,0,a,o),e.renderAxis(h,s,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,r,n,u,"asso",t),e.renderRecombLine(h,s,c,r,n),e.renderDots(h,s,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,r,n,u,"asso",t),d=document.getElementById("ld_plot_"+t.replaceAll(" ","_")+e.sectionId),d.setAttribute("width",i),d.setAttribute("height",o),d.setAttribute("style","width:"+i/2+"px;height:"+o/2+"px;"),h=d.getContext("2d"),h.clearRect(0,0,i,o),e.renderAxis(h,l,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,1,0,u,"LD",t),e.renderDots(h,l,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,1,0,u,"LD",t)}))},renderDots:function(t,e,n,r,a,i,o,s,c,u){var d=this,h=this.adjPlotMargin.left,p=this.adjPlotMargin.top+n,f=e/(i-o),_=n/(r-a);if("asso"==c){this.assoPos[u]={};var g=this.renderConfig["x axis field"],m=this.renderConfig["y axis field"];if(this.renderConfig["star key"]&&this.isSectionPage){var v=this.adjPlotMargin.top-3*this.adjPlotMargin.bump,y=this.adjPlotMargin.top+n+2*this.adjPlotMargin.bump;this.starItems.map((function(e){var n=h+(e.columns[d.renderConfig["x axis field"]]-o)*f;d.utils.plotUtils.renderDashedLine(t,n,v,n,y,3,"#FFAA0055",[6,2]),d.renderDot(t,n,y,"#FFAA0055",5)}))}if("Combined"!=u)for(var b=0,x=Object.entries(this.assoData[u].data);b<x.length;b++){var w=Object(l["a"])(x[b],2),C=w[0],P=w[1];if(P[g]>=o&&P[g]<=i){var k=h+(P[g]-o)*f,M=p-(P[m]-a)*_;this.feedPosData(this.assoPos[u],Math.round(k/2),Math.round(M/2),C);var E=this.getDotColor(this.ldData[u].data[C]);C==this.ldData[u].refVariant?this.renderConfig["star key"]&&1==this.checkStared(C)?this.utils.plotUtils.renderStar(t,k,M,5,10,6,E,E):this.renderDiamond(t,k,M,E):this.renderConfig["star key"]&&1==this.checkStared(C)?this.utils.plotUtils.renderStar(t,k,M,5,10,6,E,E):this.renderDot(t,k,M,E)}}if("Combined"==u){var D={};this.plotsList.map((function(e,n){if("Combined"!=e)for(var r=0,s=Object.entries(d.assoData[e].data);r<s.length;r++){var c=Object(l["a"])(s[r],2),v=c[0],y=c[1];if(y[g]>=o&&y[g]<=i){if(D[v])D[v]&&(D[v].xValue.push(y[g]),D[v].yValue.push(y[m]));else{var b={xValue:[],yValue:[]};b.xValue.push(y[g]),b.yValue.push(y[m]),D[v]=b}var x=h+(y[g]-o)*f,w=p-(y[m]-a)*_;d.feedPosData(d.assoPos[u],Math.round(x/2),Math.round(w/2),v);var C=d.compareGroupColors[n];v==d.ldData[e].refVariant?d.renderConfig["star key"]&&1==d.checkStared(v)?d.utils.plotUtils.renderStar(t,x,w,5,10,6,C,C):d.renderDiamond(t,x,w,C):d.renderConfig["star key"]&&1==d.checkStared(v)?d.utils.plotUtils.renderStar(t,x,w,5,10,6,C,C):d.renderDot(t,x,w,C)}}})),this.renderConntingLine(t,h,p,o,a,f,_,D)}}if("LD"==c){if(this.ldPos[u]={},"Combined"!=u)if(0==Object.keys(this.ldData[u].data).length)t.textAlign="center",t.fillStyle="#000000",t.fillText("No LD data loaded against "+this.ldData[u].refVariant,this.adjPlotMargin.left+e/2,this.adjPlotMargin.top+n/2);else for(var O=this.renderConfig["y axis field"],L=0,j=Object.entries(this.ldData[u].data);L<j.length;L++){var S=Object(l["a"])(j[L],2),A=S[0],I=S[1];if(this.assoData[u].data[A]){var T=h+I*f,B=p-(this.assoData[u].data[A][O]-a)*_;this.feedPosData(this.ldPos[u],Math.round(T/2),Math.round(B/2),A);var R=this.getDotColor(I);A==this.ldData[u].refVariant?this.renderConfig["star key"]&&1==this.checkStared(A)?this.utils.plotUtils.renderStar(t,T,B,5,10,6,R,R):this.renderDiamond(t,T,B,R):this.renderConfig["star key"]&&1==this.checkStared(A)?this.utils.plotUtils.renderStar(t,T,B,5,10,6,R,R):this.renderDot(t,T,B,R)}}if("Combined"==u){var F={},G=this.renderConfig["y axis field"];this.plotsList.map((function(e,n){if("Combined"!=e){var r=d.compareGroupColors[n];if(0!=Object.keys(d.ldData[e].data).length)for(var i=0,o=Object.entries(d.ldData[e].data);i<o.length;i++){var s=Object(l["a"])(o[i],2),c=s[0],g=s[1];if(d.assoData[e].data[c]){if(F[c])F[c]&&(F[c].xValue.push(g),F[c].yValue.push(d.assoData[e].data[c][G]));else{var m={xValue:[],yValue:[]};m.xValue.push(g),m.yValue.push(d.assoData[e].data[c][G]),F[c]=m}var v=h+g*f,y=p-(d.assoData[e].data[c][G]-a)*_;d.feedPosData(d.ldPos[u],Math.round(v/2),Math.round(y/2),c),c==d.ldData[e].refVariant?d.renderConfig["star key"]&&1==d.checkStared(c)?d.utils.plotUtils.renderStar(t,v,y,5,10,

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f=Math.round(this.adjPlotMargin.left+e+s);"asso"==l&&(t.moveTo(f,this.adjPlotMargin.top),t.lineTo(f,n+this.adjPlotMargin.top+s),t.stroke()),t.moveTo(this.adjPlotMargin.left-s,n+this.adjPlotMargin.top+s),t.lineTo("asso"==l?e+this.adjPlotMargin.left+s:e+this.adjPlotMargin.left,n+this.adjPlotMargin.top+s),t.stroke();for(var _=(r-a)/5,g=n/5,m=0;m<6;m++){var v=this.adjPlotMargin.top+m*g,y=Math.floor(v);t.moveTo(this.adjPlotMargin.left-2*s,y),t.lineTo(this.adjPlotMargin.left-s,y),t.stroke(),t.textAlign="right";var b=this.utils.Formatters.decimalFormatter(a+m*_,d);b+=u>=1e5?"k":"",t.fillText(b,this.adjPlotMargin.left-3*s,this.adjPlotMargin.top+n+s-m*g)}if("asso"==l)for(var x=20,w=n/5,C=0,P=0;P<6;P++){var k=this.adjPlotMargin.top+P*w,M=Math.floor(k);t.moveTo(f,M),t.lineTo(f+s,M),t.stroke(),t.textAlign="left",t.fillText(C+P*x,this.adjPlotMargin.left+e+3*s,this.adjPlotMargin.top+n+5-P*w)}for(var E="asso"==l?Math.ceil((i-o)/5):.2,D=e/5,O=0;O<6;O++){var L=this.adjPlotMargin.left+O*D,j=Math.floor(L);t.moveTo(j,this.adjPlotMargin.top+n+s),t.lineTo(j,this.adjPlotMargin.top+n+2*s),t.stroke(),t.textAlign="center";var S=this.utils.Formatters.decimalFormatter(o+O*E,p);S=S>=1e5?Math.round(.001*S)+"k":S,t.fillText(S,j,this.adjPlotMargin.top+n+4*s)}if(t.textAlign="center",t.rotate(-2*Math.PI/4),t.fillText(this.renderConfig["y axis label"],-(this.adjPlotMargin.top+n/2),s+24),"asso"==l&&t.fillText("Recombination Rate (cM/Mb)",-(this.adjPlotMargin.top+n/2),2*this.adjPlotMargin.left+e-(s+24)),t.rotate(-2*Math.PI/4*3),t.fillText("LD"==l?"LD(r2)":this.renderConfig["x axis label"],e/2+this.adjPlotMargin.left,this.adjPlotMargin.top+this.adjPlotMargin.bottom+n-24),"LD"==l&&"Combined"==c)for(var A=e/5,I=0;I<5;I++){var T=this.adjPlotMargin.left+I*A,B=Math.floor(T);t.fillStyle=this.ldColor[I],t.fillRect(B,this.adjPlotMargin.top,A-1,n)}}}});d()((function(){}));var 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1h((function(e,n){var r=document.getElementById(t.canvasId(n));r&&r.classList.remove("hover")}))},onCanvasMouseLeave:function(){this.localHoverActive=!1,this.activePlotIndex=null,this.setHighlightedRowKey(null),this.hidePanel(),this.rowKeyField&&this.$emit("hover-key-change",null)},setHighlightedRowKey:function(t){var e=t||null;e!==this.highlightedRowKey&&(this.highlightedRowKey=e,this.scheduleRenderPlot())},drawHighlightRing:function(t,e,n,r){t.save(),t.beginPath(),t.arc(e,n,r+6,0,2*Math.PI),t.strokeStyle="#ffffff",t.lineWidth=5,t.stroke(),t.beginPath(),t.arc(e,n,r+6,0,2*Math.PI),t.strokeStyle="#e07b39",t.lineWidth=3,t.stroke(),t.restore()},rowKeyForDatum:function(t){if(!this.rowKeyField||!t)return null;var e=t[this.rowKeyField];return null==e||""===e?null:String(e)},buildHoverHtml:function(t,e){if(!t)return"";var n,r="";e["on hover"]?e["on hover"].forEach((function(n,a){var i,o=n,s=o?"<b>".concat(o,":</b> "):"";r+='<span class="gene-on-clicked-dot-scatter">\n\t\t\t\t\t'.concat(s,"\n\t\t\t\t\t").concat(null!==(i=t[n])&&void 0!==i?i:"","\n\t\t\t\t\t</span><br>"),a<e["on hover"].length-1&&(r+="<hr>")})):r='<span class="gene-on-clicked-dot-scatter">'.concat(null!==(n=t[e["render by"]])&&void 0!==n?n:"","</span>");return r},primaryEntryForRowKey:function(t){var e=this,n=this.rowKeyToCanvasPos[t];return n&&n.length?null!=this.activePlotIndex&&n.find((function(t){return t.plotIndex===e.activePlotIndex}))||n[0]:null},tooltipContainerRect:function(){var t=this.$el;return t?t.getBoundingClientRect():null},positionTooltipAtClient:function(t,e,n){var r=this.tooltipContainerRect();t&&r&&(t.style.top="".concat(n-r.top,"px"),t.style.left="".concat(e-r.left+15,"px"))},positionTooltipAtEntry:function(t,e){var n=document.getElementById(this.canvasId(e.plotIndex));if(t&&n&&e){var r=n.getBoundingClientRect(),a=r.left+e.xPos/n.width*r.width,i=r.top+e.yPos/n.height*r.height;this.positionTooltipAtClient(t,a,i)}},showTooltipForRowKey:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],n=this.primaryEntryForRowKey(t);if(n){var r=document.getElementById("clicked_dot_value"+this.sectionId),a=document.getElementById(this.canvasId(n.plotIndex));r&&a&&(r.classList.remove("hidden"),this.positionTooltipAtEntry(r,n),r.innerHTML=this.buildHoverHtml(n.row,this.resolvedPlots[n.plotIndex].renderConfig),a.classList.add("hover"),e&&this.rowKeyField&&this.$emit("hover-key-change",t))}},checkPosition:function(t,e){var n;this.activePlotIndex=e;var r=null===(n=this.resolvedPlots[e])||void 0===n?void 0:n.renderConfig;if(r){var a=document.getElementById("clicked_dot_value"+this.sectionId);a.classList.remove("hidden");var i=t,o=document.getElementById(this.canvasId(e)).getBoundingClientRect(),s=document.getElementById(this.canvasId(e)),l=s?s.width/o.width:1,c=s?s.height/o.height:1,u=Math.floor((i.clientX-o.left)*l/2),d=Math.floor((i.clientY-o.top)*c/2);this.positionTooltipAtClient(a,i.clientX,i.clientY);for(var h=this.posDataByPlot[e]||{},p="",f=-3;f<=3;f++)if(h[u+f])for(var _=-3;_<=3;_++)h[u+f][d+_]&&(h[u+f][d+_].map((function(t,e){var n=r["on hover"][e],a=n?"<b>".concat(n,":</b> "):"";p+='<span class="gene-on-clicked-dot-scatter">\n\t\t\t\t\t\t\t\t\t'.concat(a,"\n\t\t\t\t\t\t\t\t\t").concat(t,"\n\t\t\t\t\t\t\t\t\t</span><br>")})),p+=r["on hover"]?"<hr>":"");if(""!=p){if(a.innerHTML=p,s.classList.add("hover"),this.localHoverActive=!0,this.rowKeyField){var g=this.findRowKeyNearCanvasPoint(u,d,e);this.setHighlightedRowKey(g),this.$emit("hover-key-change",g)}}else a.innerHTML=p,a.classList.add("hidden"),s.classList.remove("hover"),this.localHoverActive=!1,this.setHighlightedRowKey(null),this.rowKeyField&&this.$emit("hover-key-change",null)}},findRowKeyNearCanvasPoint:function(t,e,n){for(var r=null,a=1/0,o=0,l=Object.entries(this.rowKeyToCanvasPos);o<l.length;o++){var c,u=Object(s["a"])(l[o],2),d=u[0],h=u[1],p=Object(i["a"])(h);try{for(p.s();!(c=p.n()).done;){var f=c.value;if(f.plotIndex===n){var _=Math.hypot(f.x-t,f.y-e);_<=8&&_<a&&(a=_,r=d)}}}catch(g){p.e(g)}finally{p.f()}}return r},clearPlot:function(){var t=this;this.posDataByPlot={},this.rowKeyToCanvasPos={}

1,this.resolvedPlots.forEach((function(e,n){var r=e.renderConfig;if(r){var a=document.getElementById(t.canvasId(n));if(a){var i=a.getContext("2d");i.clearRect(0,0,2*r.width+240,2*r.height+240)}}}))},dotFillStyle:function(t){var e="#00000080";if(!this.colorByField)return e;var n=t[this.colorByField],r=this.colorScaleMap[n]||e;return null!=this.hoveredLegendValue&&n!==this.hoveredLegendValue?"#80808014":this.withAlpha(r)},withAlpha:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:"CC";return t?9===String(t).length?t:"".concat(t).concat(e):"#00000080"},registerRowPosition:function(t,e,n,r,a,i,o){if(e){this.rowKeyToCanvasPos[e]||(this.rowKeyToCanvasPos[e]=[]);var s=this.rowKeyToCanvasPos[e].find((function(e){return e.plotIndex===t})),l={plotIndex:t,x:n,y:r,xPos:a,yPos:i,row:o};s?Object.assign(s,l):this.rowKeyToCanvasPos[e].push(l)}},renderSinglePlot:function(t,e){var n=this,r=this.renderDataFor(e);if(r.length){var a=[],i=[],o=2*e.width,s=2*e.height,l=149,c=89,u=.04*o,d=.04*s,h=document.getElementById(this.canvasId(t));if(h){var p=h.getContext("2d");p.clearRect(0,0,o+240,s+240),p.beginPath(),p.lineWidth=1,p.strokeStyle="#000000",p.setLineDash([]),r.map((function(t){a.push(t[e["x axis field"]]),i.push(t[e["y axis field"]])}));var f=8,_=Math.min.apply(Math,a),g=Math.max.apply(Math,a),m=Math.min.apply(Math,i),v=Math.max.apply(Math,i),y=this.utils.uiUtils.getAxisTicks(_,g),b=this.utils.uiUtils.getAxisTicks(m,v);p.moveTo(l,s+c+d),p.lineTo(o+l+u,s+c+d),p.stroke();for(var x=o/5,w=0;w<6;w++)p.moveTo(l+w*x+u,c+s+d),p.lineTo(l+w*x+u,s+c+10+d),p.stroke(),p.font="24px Arial",p.textAlign="center",p.fillStyle="#000000",y.lo+w*y.step==0?p.fillText(0,l+w*x+u,c+s+34+d):p.fillText(this.utils.Formatters.floatFormatter(y.lo+w*y.step),l+w*x+u,c+s+34+d);p.font="28px Arial",p.textAlign="center",p.fillStyle="#000000",p.fillText(e["x axis label"],l+o/2,c+s+70+d),p.moveTo(l,c),p.lineTo(l,s+c+d),p.stroke();for(var C=s/5,P=0;P<6;P++)p.moveTo(l-5,c+P*C),p.lineTo(l,c+P*C),p.stroke(),p.font="24px Arial",p.textAlign="right",p.fillStyle="#000000",b.lo+b.step*P==0?p.fillText(0,l-14,c+(5-P)*C+3):p.fillText(this.utils.Formatters.floatFormatter(b.lo+b.step*P),l-14,c+(5-P)*C+3);p.font="28px Arial",p.textAlign="center",p.fillStyle="#000000",p.rotate(-90*Math.PI/180),p.fillText(e["y axis label"],-(c+s/2),l-110),p.rotate(90*Math.PI/180);var k=y.lo+5*y.step,M=b.lo+5*b.step,E={};if(this.posDataByPlot[t]=E,r.map((function(r){var a=l+u+o*((r[e["x axis field"]]-y.lo)/(k-y.lo)),i=c+s-s*((r[e["y axis field"]]-b.lo)/(M-b.lo)),d=Math.round(a/2),h=Math.round(i/2),_=n.rowKeyForDatum(r);n.registerRowPosition(t,_,d,h,a,i,r),E[d]||(E[d]={}),E[d][h]=[],e["on hover"]?e["on hover"].forEach((function(t){E[d][h].push(r[t])})):E[d][h].push(r[e["render by"]]),p.fillStyle=n.dotFillStyle(r),p.lineWidth=0,p.beginPath(),p.arc(a,i,f,0,2*Math.PI),p.fill(),e["dot label score"]&&(p.font="24px 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n("filter-control-template",{staticClass:"filter-col-sm",attrs:{field:t.field,type:"number",predicate:t.predicate,pillFormatter:t.pillFormatter,placeholder:t.placeholder,color:t.color,computedField:t.computedField,multiple:!1}},[t._t("default",(function(){return[t._v(t._s(t.field))]}))],2)},a=[],i=(n("99af"),n("2b0e")),o=n("27d5"),s=i["default"].component("filter-greater-control",{props:{field:String,computedField:Function,predicate:{type:Function,default:function(t,e){return t>=e}},pillFormatter:{type:Function,default:function(t){return"".concat(t.field," â¥ ").concat(t.threshold)}},color:{type:String},placeholder:String},components:{FilterControlTemplate:o["a"]}}),l=s,c=n("2877"),u=Object(c["a"])(l,r,a,!1,null,null,null);e["a"]=u.exports},9487:function(t,e,n){"use strict";n("70db")},"948d":function(t,e,n){},"966c":function(t,e,n){"use strict";n("02b9")},"97b5":function(t,e,n){"use strict";var r=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"heatmap-wrapper"},[t._m(0),n("div",{staticClass:"heatmap-content",attrs:{id:"heatmapContent",hidden:this.hideHeatmap}},[t.renderConfig.label?n("div",{staticClass:"heatmap-label",domProps:{innerHTML:t._s(t.renderConfig.label)}}):t._e(),t.renderConfig.legend?n("div",{staticClass:"heatmap-legend",domProps:{innerHTML:t._s(t.renderConfig.legend)}}):t._e(),t.renderConfig.legend?n("div",{staticClass:"heatmap-scale-legend",attrs:{id:"heatmap_scale_legend"}}):t._e(),n("div",{staticClass:"heatmap-canvas-wrapper",attrs:{id:"heatmapPlotWrapper"}},[n("div",{staticClass:"heatmap-columns-wrapper",attrs:{id:"heatmapColumnsWrapper"}}),n("div",{staticClass:"heatmap-rows-wrapper",attrs:{id:"heatmapRowsWrapper"}}),n("div",{staticClass:"heatmap-canvas-wrapper",attrs:{id:"heatmapCanvasWrapper"}},[t.renderConfig?n("canvas",{attrs:{id:"heatmap",width:"",height:""},on:{mouseleave:t.hidePanel,mousemove:t.checkPosition}}):t._e()])])])])},a=[function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"clicked-cell-value hidden",attrs:{id:"clicked_cell_value"}},[n("div",{attrs:{id:"clicked_cell_value_content"}})])}],i=n("5530"),o=(n("a4d3"),n("e01a"),n("99af"),n("cb29"),n("4de4"),n("caad"),n("d81d"),n("14d9"),n("fb6a"),n("4e82"),n("d3b7"),n("07ac"),n("4c53"),n("0643"),n("2382"),n("4e3e"),n("a573"),n("159b"),n("2b0e")),s=n("1157"),l=n.n(s),c=n("a282"),u=n("1812"),d=n("b1e0"),h=n("529c");o["default"].use(d["a"]);var p=o["default"].component("heatmap",{props:{heatmapData:{type:Array,required:!0},renderConfig:{type:Object,required:!0},alwaysHideTooltip:{type:Boolean,default:!1}},data:function(){return{squareData:{},canvasHover:!1,hideHeatmap:!1,phenotypeMap:this.$store.state.bioPortal.phenotypeMap,colors:{},separator:"___",lo:null,mid:null,hi:null}},modules:{uiUtils:c["a"],Formatters:h["a"]}

1,mounted:function(){this.colors=this.groupColors(),this.renderHeatmap(),this.renderScaleLegend()},beforeDestroy:function(){},computed:{renderData:function(){var t=this;if(0===this.heatmapData.length)return{columns:[],rows:[],empty:!0};this.hideHeatmap=!1,this.renderConfig.colorByPhenotype&&this.getExtremes();var e={},n=this.heatmapData,r=n.map((function(e){return e[t.renderConfig.rowField]})).filter((function(t,e,n){return n.indexOf(t)==e})).filter((function(t,e,n){return""!=t})),a=n.map((function(e){return e[t.renderConfig.columnField]})).filter((function(t,e,n){return n.indexOf(t)==e})).filter((function(t,e,n){return""!=t}));e["rows"]=r.sort((function(e,n){return t.renderConfig.sortRowsDescending?-1*e.localeCompare(n,void 0,{sensitivity:"base"}):1}));var i=a.sort((function(e,n){var r=t.applyPrefix(e),a=t.applyPrefix(n);return r.localeCompare(a,void 0,{sensitivity:"base"})}));return e["columns"]=i,r.map((function(t){e[t]={},a.map((function(n){e[t][n]={}}))})),n.map((function(n){var r=t.renderConfig.rowField,a=t.renderConfig.columnField;e[n[r]][n[a]]["main"]=n[t.renderConfig.main.field],t.renderConfig.sub&&(e[n[r]][n[a]]["sub"]=n[t.renderConfig.sub.field])})),e},boxSize:function(){return 1.5*this.renderConfig.fontSize}},watch:{renderData:function(t){t.empty?this.hideHeatmap=!0:(this.hideHeatmap=!1,this.renderHeatmap())}},methods:Object(i["a"])(Object(i["a"])({},c["a"]),{},{hidePanel:function(){c["a"].hideElement("clicked_cell_value"),this.renderHeatmap()},renderScaleLegend:function(){var t=document.getElementById("heatmap_scale_legend"),e="<div class='scale-legend-main-field'><div class='field-label'>"+this.renderConfig.main.label+":</div> ",n=(this.renderConfig.main.low,this.renderConfig.main.middle),r=this.renderConfig.main.high;if(r!=n){var a=(r-n)/5,i=0==n?"0.00":h["a"].floatFormatter(n);e+="<div class='scale-legend-main-colors'><div class='scale-color' style='background-color: rgb(255,255,255)'>"+i+"</div>";for(var o=1;o<6;o++){var s=1-.2*o;s*=255,s=0==s?0:h["a"].intFormatter(s),e+="<div class='scale-color' style='background-color: rgb(255,"+s+","+s+")'>"+h["a"].floatFormatter(a*o)+"</div>"}e+="</div></div>"}if(this.renderConfig.sub){e+="<div class='scale-legend-sub-field'><div class='field-label'>"+this.renderConfig.sub.label+"</div>:";var l,c=this.renderConfig.sub.valueRange,u=this.renderConfig.sub.direction,d=.75*this.boxSize;c.map((function(t,n){"positive"==u?(l=d*((n+1)/c.length),e+="<div class='sub-legend-steps'> >= "):(l=d*((c.length-n)/c.length),e+="<div class='sub-legend-steps'> <= "),e+=t+": <span style = 'display: inline-block; background-color: #00000075; width:"+l+"px; height:"+l+"px; border-radius:"+l/2+"px;'></span></div>"})),e+="</div>"}t.innerHTML=e},checkPosition:function(t){if(!this.alwaysHideTooltip){var e=t,n=e.target.getBoundingClientRect(),r=Math.floor(e.clientX-n.left),a=Math.floor(e.clientY-n.top),i=Math.floor((e.clientX-n.left)/this.boxSize),o=Math.floor((e.clientY-n.top)/this.boxSize),s="";if(i>=0&&o>=0&&this.squareData[o]&&this.squareData[o][i]){s+='<span class="field-on-clicked-cell">'+this.removeRowPrefix(this.renderData.rows[o])+"</sub>",s+='<span class="field-on-clicked-cell">';var l=this.renderConfig.sortPhenotypeColumns?this.getPhenotypeDescription(this.renderData.columns[i]):this.renderData.columns[i];s+=l+"</sub>",s+='<span class="content-on-clicked-cell"><b>'+this.renderConfig.main.label+": </b>"+this.squareData[o][i].main.value+"</span>",this.squareData[o][i].sub&&(s+='<span class="content-on-clicked-cell"><b>'+this.renderConfig.sub.label+": </b>"+this.squareData[o][i].sub.value+"</span>"),this.squareData[o][i].group&&(s+='<span class="content-on-clicked-cell"><b>'+this.squareData[o][i].group.field+": </b>"+this.squareData[o][i].group.value+"</span>")}var c=document.getElementById("clicked_cell_value"),u=document.getElementById("clicked_cell_value_content"),d=document.getElementById("heatmapCanvasWrapper").getBoundingClientRect(),h=d.left,p=document.getElementById("heatmapContent").offsetHeight-document.getElementById("heatmapPlotWrapper").offsetHeight+document.getElementById("heatmapColumnsWrapper").offsetWidth;""!=s?(u.innerHTML=s,c.classList.remove("hidden"),c.style.top=p+a+"px",c.style.left=h-30+r+"px"):c.classList.add("hidden"),this.renderHeatmap(i,o)}},renderHeatmap:function(t,e){var n=this;this.squareData={},document.getElementById("heatmapColumnsWrapper").innerHTML="",document.getElementById("heatmapRowsWrapper").innerHTML="";var r=1.5*this.renderConfig.fontSize*this.renderData.columns.length,a=this.boxSize*this.renderData.rows.length;document.getElementById("heatmapColumnsWrapper").style.fontSize=this.renderConfig.fontSize+"px",document.getElementById("heatmapRowsWrapper").style.fontSize=this.renderConfig.fontSize+"px",this.renderData.columns.map((function(t){var e=document.createElement("div"),r=n.truncateColumn(n.getPhenotypeDescription(t)),a=document.createTextNode(r);e.appendChild(a),e.setAttribute("style","height: "+n.boxSize+"px;"),document.getElementById("heatmapColumnsWrapper").appendChild(e)})),this.renderData.rows.map((function(t){var e=document.createElement("div"),r=document.createTextNode(n.removeRowPrefix(t));e.appendChild(r),e.setAttribute("style","height: "+n.boxSize+"px;"),document.getElementById("heatmapRowsWrapper").appendChild(e)}));document.getElementById("heatmapColumnsWrapper").offsetHeight,document.getElementById("heatmapColumnsWrapper").offsetWidth;var 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g=t.assoData[i].data[c][e];t.assoData[i].variantData[g]=t.assoData[i].data[c]}})),t.fixedRefVariants[i]&&t.assoData[i].data[t.fixedRefVariants[i]]?t.ldData[i].refVariant=t.fixedRefVariants[i]:t.ldData[i].refVariant=C}var P=Object(f["a"])(new Set(t.ldData[i].population));t.ldData[i].population=P.length>1?"ALL":t.renderConfig["ld server"]?t.renderConfig["ld server"].populations[P[0]]:null})),1==i.includes("Combined")&&i.map((function(e){var n=t.assoData[e].yAxHigh,r=t.assoData[e].yAxLow;t.assoData.Combined.yAxHigh=null==t.assoData.Combined.yAxHigh||n>t.assoData.Combined.yAxHigh?Math.ceil(n):t.assoData.Combined.yAxHigh,t.assoData.Combined.yAxLow=null==t.assoData.Combined.yAxLow||r<t.assoData.Combined.yAxLow?Math.floor(r):t.assoData.Combined.yAxLow})),this.setUpWrappers(),i}return null},searchingRegion:function(){if(null==this.region)return null;var t={};t["chr"]=parseInt(this.region.split(":")[0],10);var e=this.region.split(":")[1].split("-"),n=parseInt(e[0],10),r=parseInt(e[1],10),a=r-n;if(this.regionZoom>0){var i=Math.round(a*(this.regionZoom/200)),o=Math.round(i*(this.regionViewArea/100));t["start"]=n+i+o,t["end"]=r-i+o}else 0==this.regionZoom&&(t["start"]=n,t["end"]=r);return t},globalLDData:function(){return null!==this.$store.state.topLevelLDData?this.$store.state.topLevelLDData:this.ldData}},watch:{hoverPos:function(t){this.renderPlots()},staredVariants:function(t){this.renderPlots()},starItems:function(t){this.starGroups=Object(f["a"])(new Set(t.map((function(t){return t.section})))).sort(),this.renderPlots()},ldData:{handler:function(t,e){if(!Object(m["isEqual"])(t,e)&&"send"===this.renderConfig.propagateLD){var n={data:t,server:this.renderConfig["ld server"]};this.$emit("ld-data-loaded",n)}},deep:!0}}

1,methods:{downloadImage:function(t,e,n,r,a,i){if("svg"==n){var o=i;this.$refs[o].renderPlot(a),this.utils.uiUtils.downloadImg(t,e,n,r)}else"png"==n&&this.utils.uiUtils.downloadImg(t,e,n)},onResize:function(t){this.renderPlots()},getColumns:function(t){var e,n=this;if(null!=this.dataComparisonConfig)for(var r=0,a=Object.entries(this.plotData);r<a.length;r++){var i=Object(_["a"])(a[r],2),o=(i[0],i[1]);o[this.renderConfig["star key"]]==t&&(e=o)}else e=this.plotData.filter((function(e){return e[n.renderConfig["star key"]]==t}))[0];return e},checkStared:function(t,e){var n,r=this,a=t;if(e)for(var i=0,o=Object.entries(this.assoData);i<o.length;i++){var s=Object(_["a"])(o[i],2),l=(s[0],s[1]);l.data[t]&&(a=l.data[t][this.renderConfig["star key"]])}return n=this.isSectionPage?this.starItems.filter((function(t){return t.type==r.renderConfig["star key"]})).map((function(t){return t.id})):this.pkgDataSelected.filter((function(t){return t.type==r.renderConfig["star key"]})).map((function(t){return t.id})),!!n.includes(a)},addStarItem:function(t){for(var e,n=0,r=Object.entries(this.assoData);n<r.length;n++){var a=Object(_["a"])(r[n],2),i=(a[0],a[1]);i.data[t]&&(e=i.data[t][this.renderConfig["star key"]])}if(this.isSectionPage){var o=Object(f["a"])(new Set(this.starItems)),s={type:this.renderConfig["star key"],id:e,columns:this.getColumns(e),section:this.sectionId};o.push(s),this.$emit("on-star",o)}else this.$store.dispatch("pkgDataSelected",{type:this.renderConfig["star key"],id:e,action:"add"})},removeStarItem:function(t){for(var e,n=0,r=Object.entries(this.assoData);n<r.length;n++){var a=Object(_["a"])(r[n],2),i=(a[0],a[1]);i.data[t]&&(e=i.data[t][this.renderConfig["star key"]])}if(this.isSectionPage){var o=Object(f["a"])(new Set(this.starItems)).filter((function(t){return t.id!=e}));this.$emit("on-star",o)}else this.$store.dispatch("pkgDataSelected",{type:this.renderConfig["star key"],id:e,action:"remove"})},resetLdReference:function(t,e){var n=this,r=this.renderConfig["ld server"]["ref variant field"],a=this.assoData[t].data[e][r];this.showHidePanel("#fixedInfoBox"+this.sectionId),"All"!=t?(this.ldData[t].refVariant=a,this.fixedRefVariants[t]=a,this.ldData[t].data=null,this.refProperties.refVariants[t]=a):"All"==t&&this.plotsList.map((function(t){"combined"!=t&&(n.ldData[t].refVariant=a,n.fixedRefVariants[t]=a,n.ldData[t].data=null,n.refProperties.refVariants[t]=a)})),this.callForLDData()},showHidePanel:function(t){var e=document.querySelector(t);e.classList.contains("hidden")?e.classList.remove("hidden"):e.classList.add("hidden")},showHideSplitPlots:function(){this.plotsList.map((function(t){if("Combined"!=t){var e=document.querySelector("#plotsWrapper"+t.replaceAll(" ","_"));e.classList.contains("hidden")?e.classList.remove("hidden"):e.classList.add("hidden")}}))},getDotsOnPosition:function(t,e,n,r){for(var a="asso"==t?this.assoPos[e]:this.ldPos[e],i=[],o=-5;o<=5;o++)for(var s=-5;s<=5;s++)void 0!=a[n+o]&&void 0!=a[n+o][r+s]&&(i=i.concat(a[n+o][r+s]));return i},resetPosMarker:function(){var t=document.getElementById(this.sectionId+"_xPosMarker");t.style.left="0px",t.style.top="0px",t.style.height="1px"},checkPosition:function(t,e,n,r){var a=this,i=t.target.getBoundingClientRect(),o=Math.floor(t.clientX-i.left),s=Math.floor(t.clientY-i.top),l=document.getElementById("assoPlotsWrapper"+e+this.sectionId).getBoundingClientRect();if(this.getPosInfo(o,s,e,n,r),"move"==r&&o>=this.adjPlotMargin.left/2&&o<=i.width-this.adjPlotMargin.right/2&&s>=i.height-this.adjPlotMargin.bottom/2){var c=document.getElementById(this.sectionId+"_xPosMarker");c.style.left=o+"px",c.style.top=l.height-i.height+"px",c.style.height=i.height-this.adjPlotMargin.bottom/2+"px"}else this.resetPosMarker();if("click"==r&&o>=this.adjPlotMargin.left/2&&o<=i.width-this.adjPlotMargin.right/2&&s>=i.height-this.adjPlotMargin.bottom/2){var u=i.width-(this.adjPlotMargin.left/2+this.adjPlotMargin.right/2),d=o-this.adjPlotMargin.left/2,h=this.convertXPos(d,u),p=!1,f=[];this.hoverPos.length>0&&(this.hoverPos.map((function(t){var e=2*Math.floor((a.searchingRegion.end-a.searchingRegion.start)/u);t>=h-e&&t<=h+e?p=!0:f.push(t)})),this.$root.hoverPos=f),p||this.$root.hoverPos.push(h)}},convertXPos:function(t,e){var n=(this.searchingRegion.end-this.searchingRegion.start)/e,r=t*n+this.searchingRegion.start;return Math.floor(r)},getPosInfo:function(t,e,n,r,a){var i=this,o=this.getDotsOnPosition(r,n,t,e);o=Object(f["a"])(new Set(o));var s="asso"==r?"#assoInfoBox"+n.replaceAll(" ","_")+this.sectionId:"#ldInfoBox"+n.replaceAll(" ","_")+this.sectionId,l="asso"==r?"#asso_plot_"+n.replaceAll(" ","_")+this.sectionId:"#ld_plot_"+n.replaceAll(" ","_")+this.sectionId,c=document.querySelector(s),u=document.querySelector(l);

1if(o.length>0)if("move"==a){var d=o.length>5?"<span class='info-box-direction'>Viewing 5 of "+o.length+" variants. Click to view full list or to change LD reference variant.</span><br />":"<span class='info-box-direction'>Click to change LD reference variant.</span><br />";o.map((function(t,e){if(e<5){if(d+="<strong>"+t+"</strong>",i.renderConfig["star key"]){var r=i.assoData[n].data[t][i.renderConfig["star key"]];d+=1==i.checkStared(r)?"&nbsp;<span style='color:#ffcc00'>&#9733;</span>":"&nbsp;<span style='color:#ffcc00'>&#9734;</span>"}d+="<br />",i.renderConfig["hover content"].map((function(e){"Combined"!=n?d+=e+": "+i.assoData[n].data[t][e]+"<br />":"Combined"==n&&i.plotsList.map((function(n){"Combined"!=n&&i.assoData[n].data[t]&&(d+=e+"("+n+"): "+i.assoData[n].data[t][e]+"<br />")}))}))}})),c.classList.remove("hidden"),c.innerHTML=d,c.style.top=e+u.offsetTop+25+"px";var h=t/u.offsetWidth;c.style.left=t-c.offsetWidth*h+u.offsetLeft+"px"}else"click"==a&&(this.dotsClicked=o,this.showHidePanel("#fixedInfoBox"+this.sectionId));else c.classList.add("hidden")},onMouseOut:function(t){this.utils.uiUtils.removeOnMouseOut(t.replaceAll(" ","_"),1e3)},setUpWrappers:function(){this.searchingRegion&&this.callForRecombData()},callForRecombData:function(){var t=this;return Object(p["a"])(M().mark((function e(){var n,r;return M().wrap((function(e){while(1)switch(e.prev=e.next){case 0:return t.renderConfig["genome reference"]&&"GRCh38"==t.renderConfig["genome reference"]?n="https://portaldev.sph.umich.edu/api/v1/annotation/recomb/results/?build=GRCh38&filter=chromosome eq '"+t.searchingRegion.chr+"' and position gt "+t.searchingRegion.start+" and position lt "+t.searchingRegion.end:(!t.renderConfig["genome reference"]||t.renderConfig["genome reference"]&&"GRCh37"==t.renderConfig["genome reference"])&&(n="https://portaldev.sph.umich.edu/api/v1/annotation/recomb/results/?filter=id in 15 and chromosome eq '"+t.searchingRegion.chr+"' and position gt "+t.searchingRegion.start+" and position lt "+t.searchingRegion.end),e.next=3,fetch(n).then((function(t){return t.json()}));case 3:r=e.sent,t.recombData={},null==r.error&&(t.recombData["position"]=r.data.position,t.recombData["recomb_rate"]=r.data.recomb_rate,t.callForLDData());case 6:case"end":return e.stop()}}),e)})))()},callForLDData:function(){var t=this;return Object(p["a"])(M().mark((function e(){var n,r,a,i,o,s,l,c;return M().wrap((function(e){while(1)switch(e.prev=e.next){case 0:n=document.querySelectorAll(".region-plots-wrapper"),n.forEach((function(t){t.classList.remove("hidden")})),r=null,a=0;case 4:if(!(a<t.plotsList.length)){e.next=11;break}if("Combined"==t.plotsList[a]||null!=t.ldData[t.plotsList[a]].data){e.next=8;break}return r=t.plotsList[a],e.abrupt("break",11);case 8:a++,e.next=4;break;case 11:if(null==r||!t.ldData[r].population||!t.ldData[r].refVariant){e.next=19;break}return t.renderConfig["genome reference"]&&"GRCh38"==t.renderConfig["genome reference"]?i="https://portaldev.sph.umich.edu/ld/genome_builds/GRCh38/references/1000G/populations/"+t.ldData[r].population+"/variants?correlation=rsquare&variant="+t.ldData[r].refVariant+"&chrom="+t.searchingRegion.chr+"&start="+t.searchingRegion.start+"&stop="+t.searchingRegion.end+"&limit=100000":(!t.renderConfig["genome reference"]||t.renderConfig["genome reference"]&&"GRCh37"==t.renderConfig["genome reference"])&&(i="https://portaldev.sph.umich.edu/ld/genome_builds/GRCh37/references/1000G/populations/"+t.ldData[r].population+"/variants?correlation=rsquare&variant="+t.ldData[r].refVariant+"&chrom="+t.searchingRegion.chr+"&start="+t.searchingRegion.start+"&stop="+t.searchingRegion.end+"&limit=100000"),e.next=15,fetch(i).then((function(t){return t.json()}));case 15:o=e.sent,null==o.error&&(s={},o.data.variant2.map((function(t,e){s[t]=o.data.correlation[e]})),t.ldData[r].data=s,t.callForLDData()),e.next=30;break;case 19:l=M().mark((function e(){var n;return M().wrap((function(e){while(1)switch(e.prev=e.next){case 0:if("Combined"==t.plotsList[c]){e.next=4;break}return n=t.plotsList[c],Object.keys(t.plotData).map((function(e){t.plotData[e]["LDS"]=t.plotData[e]["LDS"]?t.plotData[e]["LDS"]:{},t.plotData[e]["LDS"][n]=t.renderConfig["ld server"]?t.ldData[n].data[e]:null})),e.abrupt("return",1);case 4:case"end":return e.stop()}}),e)})),c=0;case 21:if(!(c<t.plotsList.length)){e.next=28;break}return e.delegateYield(l(),"t0",23);case 23:if(!e.t0){e.next=25;break}return e.abrupt("break",28);case 25:c++,e.next=21;break;case 28:t.isSectionPage||t.$store.dispatch("filteredData",t.plotData),t.renderPlots();case 30:t.$forceUpdate();case 31:case"end":return e.stop()}}),e)})))()},renderPlots:function(t){var e=this,n=this.searchingRegion.start,r=this.searchingRegion.end,a=2*document.querySelector(".asso-plots-wrapper").clientWidth,i=700,o=this.renderConfig.height?2*this.renderConfig.height+this.adjPlotMargin.top+this.adjPlotMargin.bottom:600+this.adjPlotMargin.top+this.adjPlotMargin.bottom,s=a-(this.adjPlotMargin.left+this.adjPlotMargin.right),l=i-this.adjPlotMargin.left-this.adjPlotMargin.right,c=this.renderConfig.height?2*this.renderConfig.height:600,u=this.adjPlotMargin.bump;this.plotsList.map((function(t){var d,h;d=document.getElementById("asso_plot_"+t.replaceAll(" ","_")+e.sectionId),d.setAttribute("width",a),d.setAttribute("height",o),d.setAttribute("style","width:"+a/2+"px;

1height:"+o/2+"px;"),h=d.getContext("2d"),h.clearRect(0,0,a,o),e.renderAxis(h,s,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,r,n,u,"asso",t),h.fillStyle="#ff880025",h.fillRect(e.adjPlotMargin.left,c+e.adjPlotMargin.top+2*e.adjPlotMargin.bump+12,s,12);var p=s/(r-n);e.hoverPos.length>0&&e.hoverPos.map((function(t){var r=e.adjPlotMargin.top-e.adjPlotMargin.bump,a=e.adjPlotMargin.top+c+3*e.adjPlotMargin.bump,i=e.adjPlotMargin.left+(t-n)*p;e.utils.plotUtils.renderDashedLine(h,i,r,i,a,1,"#ff0000",[6,2])})),e.renderRecombLine(h,s,c,r,n),e.renderDots(h,s,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,r,n,u,"asso",t),d=document.getElementById("ld_plot_"+t.replaceAll(" ","_")+e.sectionId),d.setAttribute("width",i),d.setAttribute("height",o),d.setAttribute("style","width:"+i/2+"px;height:"+o/2+"px;"),h=d.getContext("2d"),h.clearRect(0,0,i,o),e.renderAxis(h,l,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,1,0,u,"LD",t),e.renderDots(h,l,c,e.assoData[t].yAxHigh,e.assoData[t].yAxLow,1,0,u,"LD",t)}))},renderDots:function(t,e,n,r,a,i,o,s,l,c){var u=this,d=this.adjPlotMargin.left,h=this.adjPlotMargin.top+n,p=e/(i-o),f=n/(r-a),g=this.renderConfig["ld server"]?this.renderConfig["ld server"]["ref variant field"]:"receive"===this.renderConfig.propagateLD?"LD Variant ID":null,m=(this.renderConfig["render by"],this.renderConfig["star key"]),v=this.renderConfig["x axis field"],y=this.renderConfig["y axis field"],b=document.createElement("canvas"),x=b.getContext("2d"),w=function(t,e,n){return x.font=e+"px "+n,x.measureText(t).width};if("asso"==l){if(this.assoPos[c]={},this.renderConfig["star key"]&&this.isSectionPage){var C=this.adjPlotMargin.top-3*this.adjPlotMargin.bump,P=this.adjPlotMargin.top+n+2*this.adjPlotMargin.bump;this.starItems.map((function(e){var n=d+(e.columns[v]-o)*p,r=u.colors.moderate[u.starGroups.indexOf(e.section)%16];u.utils.plotUtils.renderDashedLine(t,n,C,n,P,3,r,[6,2]),u.renderDot(t,n,P,r,5)}));var k=this.adjPlotMargin.bump;this.starGroups.map((function(e,r){var a=u.colors.bold[r],i=u.adjPlotMargin.top+n+u.adjPlotMargin.bottom-u.adjPlotMargin.bump;u.utils.plotUtils.renderDashedLine(t,k,i,k+50,i,3,a,[12,4]),k+=60,t.font="24px Arial",t.textAlign="start",t.fillStyle=a,t.fillText(e,k,i),k+=w(e,24,"Arial")+u.adjPlotMargin.bump}))}if("Combined"!=c)for(var M=0,E=Object.entries(this.assoData[c].data);M<E.length;M++){var D=Object(_["a"])(E[M],2),O=D[0],L=D[1];if(L[v]>=o&&L[v]<=i){var j=d+(L[v]-o)*p,S=h-(L[y]-a)*f;this.feedPosData(this.assoPos[c],Math.round(j/2),Math.round(S/2),O);var A=L[g],I=L[m],T="receive"===this.renderConfig.propagateLD?this.globalLDData.default.data[this.getGlobalDot(L)]:this.ldData[c].data[A],B=A||"receive"===this.renderConfig.propagateLD?this.getDotColor(T):"#00000030";A==this.ldData[c].refVariant?this.renderConfig["star key"]&&1==this.checkStared(I)?this.utils.plotUtils.renderStar(t,j,S,5,10,6,B,B):A?this.renderDiamond(t,j,S,B):this.renderDot(t,j,S,B):this.renderConfig["star key"]&&1==this.checkStared(I)?this.utils.plotUtils.renderStar(t,j,S,5,10,6,B,B):this.renderDot(t,j,S,B)}}if("Combined"==c){var R={};this.plotsList.map((function(e,n){if("Combined"!=e)for(var r=0,s=Object.entries(u.assoData[e].data);r<s.length;r++){var l=Object(_["a"])(s[r],2),g=l[0],m=l[1];if(m[v]>=o&&m[v]<=i){if(R[g])R[g]&&(R[g].xValue.push(m[v]),R[g].yValue.push(m[y]));else{var b={xValue:[],yValue:[]};b.xValue.push(m[v]),b.yValue.push(m[y]),R[g]=b}var x=d+(m[v]-o)*p,w=h-(m[y]-a)*f;u.feedPosData(u.assoPos[c],Math.round(x/2),Math.round(w/2),g);var C=u.compareGroupColors[n];g==u.ldData[e].refVariant?u.renderConfig["star key"]&&1==u.checkStared(g)?u.utils.plotUtils.renderStar(t,x,w,5,10,6,C,C):u.ldData[e].refVariant?u.renderDiamond(t,x,w,C):u.renderDot(t,x,w,C):u.renderConfig["star key"]&&1==u.checkStared(g)?u.utils.plotUtils.renderStar(t,x,w,5,10,6,C,C):u.renderDot(t,x,w,C)}}})),this.renderConntingLine(t,d,h,o,a,p,f,R)}}if("LD"==l&&this.renderConfig["ld server"]){if(this.ldPos[c]={},"Combined"!=c)if(0==Object.keys(this.ldData[c].data).length)t.textAlign="center",t.fillStyle="#000000",t.fillText("No LD data loaded against "+this.ldData[c].refVariant,this.adjPlotMargin.left+e/2,this.adjPlotMargin.top+n/2);else for(var F=0,G=Object.entries(this.ldData[c].data);F<G.length;F++){var W=Object(_["a"])(G[F],2),U=W[0],q=W[1];if(this.assoData[c].variantData[U]){var N=d+q*p,K=h-(this.assoData[c].variantData[U][y]-a)*f;this.feedPosData(this.ldPos[c],Math.round(N/2),Math.round(K/2),U);var 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at=i["default"].component("research-scatter-plot",{props:["plotData","renderConfig","searchParameters","dataComparisonConfig","plotMargin","compareGroupColors","isSectionPage","sectionId","starItems","utils"],data:function(){return{multiList:null,groupsList:null,colorsList:null,colorByList:null,colorByField:null,colorByGradient:null,gradientMinMax:{},posData:{},isDotPanelClick:!1,dotPanelCloseTimer:null}},modules:{},components:{},mounted:function(){window.addEventListener("resize",this.onResize),this.renderPlot()},updated:function(){this.renderPlot()},beforeDestroy:function(){window.removeEventListener("resize",this.onResize)},computed:{plotDimension:function(){var t={};t["height"]=this.renderConfig.height?2*this.renderConfig.height:600,t["width"]=this.renderConfig.width?2*this.renderConfig.width:1e3;var e=this.plotMargin;return this.renderConfig["plot margin"]&&(e.topMargin=this.renderConfig["plot margin"]["top"],e.bottomMargin=this.renderConfig["plot 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field"]]),this.renderConfig["x axis fields"].forEach((function(t){s.push(t)})),this.renderConfig["y axis fields"].forEach((function(t){s.push(t)}))):"multi plot"===this.renderConfig["render type"]&&this.renderConfig["axis fields"].forEach((function(t){i.push([t["x axis field"],t["y axis field"],t["color by"]])})),this.renderConfig["color by"].constructor!==Array&&(this.renderConfig["color by"]=[this.renderConfig["color by"]]),o={},this.renderConfig["color by"].forEach((function(t){o="object"===Object(h["a"])(t)?Object(rt["a"])(Object(rt["a"])({},o),{},Object(nt["a"])({},t["field"],[])):Object(rt["a"])(Object(rt["a"])({},o),{},Object(nt["a"])({},t,[]))})),this.colorByField=this.renderConfig["color field"]=this.renderConfig["color by"][0],this.renderConfig["color highlight"]=null,e.map((function(e){var i={};"single plot"===t.renderConfig["render type"]?(i["x"]={},t.renderConfig["x axis fields"].forEach((function(t){var n=t,r="string"==typeof e[t]?0:e[t];i["x"]=Object(rt["a"])(Object(rt["a"])({},i["x"]),{},Object(nt["a"])({},n,r))})),i["y"]={},t.renderConfig["y axis fields"].forEach((function(t){var n=t,r="string"==typeof e[t]?0:e[t];i["y"]=Object(rt["a"])(Object(rt["a"])({},i["y"]),{},Object(nt["a"])({},n,r))}))):"multi plot"===t.renderConfig["render type"]&&(i["x"]={},i["y"]={},i["color"]={},t.renderConfig["axis fields"].forEach((function(t){var n=0===e[t["x axis field"]]?0:"string"==typeof e[t["x axis field"]]?Number(e[field]):e[t["x axis field"]],r=0===e[t["y axis field"]]?0:"string"==typeof e[t["y axis field"]]?Number(e[field]):e[t["y axis field"]];if(i["x"]=Object(rt["a"])(Object(rt["a"])({},i["x"]),{},Object(nt["a"])({},t["x axis field"],n)),i["y"]=Object(rt["a"])(Object(rt["a"])({},i["y"]),{},Object(nt["a"])({},t["y axis field"],r)),t["color by"]){var a=t["color 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by"].forEach((function(t,n){i["color"]=Object(rt["a"])(Object(rt["a"])({},i["color"]),{},Object(nt["a"])({},t,e[t])),a.includes(e[t])||a.push(e[t])}))),t.renderConfig["hover content"]&&t.renderConfig["hover content"].length>0&&t.renderConfig["hover content"].map((function(t){i["hover"][t]=e[t]})),n.push(i)})),o){var l=Object.keys(o);l.forEach((function(t){if("number"===typeof o[t][0]){var e=o[t].filter((function(t){return"number"===typeof t}));e.sort((function(t,e){return t-e})),o[t]=e}}))}return this.groupsList=r.length>0?r.sort():null,this.colorsList=a.length>0?a.sort():null,this.multiList=i.length>0?i:null,this.colorByList=Object.keys(o).length>0?o:null,n}},watch:{renderData:function(t){this.renderPlot()},groupsList:function(t){this.renderPlot()},starItems:function(t){this.renderPlot()}},methods:{clearPlot:function(){},renderIndividualPlot:function(t,e,n,r){var a=this,i=[],o=[],s=r?this.plotDimension.width/2:this.plotDimension.width,l=r?this.plotDimension.height/2:this.plotDimension.height,c=this.plotDimension.plotMargin.leftMargin,u=this.plotDimension.plotMargin.topMargin,d=this.plotDimension.plotMargin.rightMargin,h=this.plotDimension.plotMargin.bottomMargin,p=this.plotDimension.plotMargin.bump,f=document.getElementById(e),_=f.getContext("2d");_.clearRect(0,0,s,l),n&&n.constructor===Array?t.map((function(t){t.xValue=t["x"][n[0]],t.yValue=t["y"][n[1]],i.push(t.xValue),o.push(t.yValue)})):t.map((function(t){t.x.constructor===Object?(t.xValue=t["x"][a.renderConfig["x axis field"]],i.push(t.xValue)):i.push(t.x),t.y.constructor===Object?(t.yValue=t["y"][a.renderConfig["y axis field"]],o.push(t.yValue)):o.push(t.y)}));var g=r?r.xMin:Math.min.apply(Math,i),m=r?r.xMax:Math.max.apply(Math,i);g==m&&(g-=.5,m+=.5);var v=r?r.yMin:Math.min.apply(Math,o),y=r?r.yMax:Math.max.apply(Math,o);v==y&&(v-=.5,y+=.5);var b={top:u,bottom:h,left:c,right:d,bump:p};if(this.multiList?(this.utils.plotUtils.renderAxisWBump(_,s,l,b,"x",5,g,m,n[0]),this.utils.plotUtils.renderAxisWBump(_,s,l,b,"y",5,v,y,n[1])):(this.utils.plotUtils.renderAxisWBump(_,s,l,b,"x",5,g,m,[this.renderConfig["x axis field"]]),this.utils.plotUtils.renderAxisWBump(_,s,l,b,"y",5,v,y,[this.renderConfig["y axis field"]])),this.colorsList&&!this.multiList){var x=0;this.colorsList.map((function(e){var n=t.filter((function(t){return t.color[a.renderConfig["color field"]]===e})),r=a.compareGroupColors[x%16];a.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,r,n,a.starItems,a.renderConfig["star key"]),x++}))}else if(this.colorByList){var w=0;if(n)if(n.constructor===Array){w=0;var C=this.renderConfig["color field"];

1n[2]&&(C=n[2]),this.colorByList[C].map((function(e){var n=t.filter((function(t){return t.color[C]===e})),r=a.compareGroupColors[w%16];a.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,r,n,a.starItems,a.renderConfig["star key"]),a.utils.plotUtils.renderBestFitLine(_,s,l,b,g,m,v,y,r,n),w++}))}else w=0,this.colorByList[this.renderConfig["color field"]].map((function(e){if(n===e){var r=t.filter((function(t){return t.color[a.renderConfig["color field"]]==e})),i=a.compareGroupColors[w%16];a.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,i,r,a.starItems,a.renderConfig["star key"]),a.utils.plotUtils.renderBestFitLine(_,s,l,b,g,m,v,y,i,r),w++}}));else if(this.renderConfig["color field gradient"]){this.colorByList[this.renderConfig["color field"]].map((function(e){var n=t.filter((function(t){return t.color[a.renderConfig["color field"]]==e})),r="#00000001";e>=a.gradientMinMax.currMin&&e<=a.gradientMinMax.currMax&&(r=a.colorFromGradientByValue(e,a.colorByList[a.renderConfig["color field"]][0],a.colorByList[a.renderConfig["color field"]][a.colorByList[a.renderConfig["color field"]].length-1])),a.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,r,n,a.starItems,a.renderConfig["star key"])}));var P=t.filter((function(t){return t.color[a.renderConfig["color field"]]>=a.gradientMinMax.currMin&&t.color[a.renderConfig["color field"]]<=a.gradientMinMax.currMax})),k="#00000050";this.utils.plotUtils.renderBestFitLine(_,s,l,b,g,m,v,y,k,P)}else{var M=this.renderConfig["color highlight"];w=0,this.colorByList[this.renderConfig["color field"]].map((function(e){var n=t.filter((function(t){return t.color[a.renderConfig["color field"]]==e})),r=a.compareGroupColors[w%16];M&&(r=r.substring(0,r.length-2),r+=M===e?"90":"05"),a.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,r,n,a.starItems,a.renderConfig["star key"]),a.utils.plotUtils.renderBestFitLine(_,s,l,b,g,m,v,y,r,n),w++}))}}else{var E=this.compareGroupColors[0];this.utils.plotUtils.renderDots(_,s,l,b,g,m,v,y,E,t,this.starItems,this.renderConfig["star key"])}if(n){_.font="26px Arial",_.fillStyle="#000000",_.textAlign="center";var D=this.renderConfig["group by"]+": "+n,O=n;n.constructor===Array&&(D="".concat(n[1]," : ").concat(n[0]),O="multi"+e.substring(e.length-1,e.length)),_.fillText(D,s/2+c/2,p+26),this.posData[O]=this.utils.plotUtils.getDotsPosData(s,l,b,g,m,v,y,t)}else this.posData=this.utils.plotUtils.getDotsPosData(s,l,b,g,m,v,y,t);return{xMin:g,xMax:m,yMin:v,yMax:y}},renderPlot:function(){var t=this;if(this.renderData.length>0)if(this.multiList)this.multiList.forEach((function(e,n){var r="scatterPlot"+t.sectionId+"multi"+n;document.getElementById(r)&&t.renderIndividualPlot(t.renderData,r,e)}));else if(this.groupsList)this.groupsList.map((function(e){var n=t.renderData.filter((function(t){return t.group==e})),r="scatterPlot"+t.sectionId+e;document.getElementById(r)&&t.renderIndividualPlot(n,r,e)}));else if(this.colorByList)this.renderIndividualPlot(this.renderData,"scatterPlot"+this.sectionId);else this.renderIndividualPlot(this.renderData,"scatterPlot"+this.sectionId)},setPlotAxisIndex:function(t,e){this.renderConfig[e+" axis field"]=t.target.value,this.renderPlot()},setColorField:function(t){t.target.parentNode.querySelector(".color-key").childNodes.forEach((function(t){t.classList.remove("selected")})),this.colorByField=this.renderConfig["color highlight"]=null,this.colorByGradient=this.renderConfig["color field gradient"]=null,this.colorByField=this.renderConfig["color field"]=t.target.value,this.renderConfig["color by"].includes(this.renderConfig["color field"])||(this.colorByGradient=this.renderConfig["color field gradient"]=this.renderConfig["color field"],this.gradientMinMax.max=this.colorByList[this.renderConfig["color field"]][this.colorByList[this.renderConfig["color field"]].length-1],this.gradientMinMax.min=this.colorByList[this.renderConfig["color field"]][0],this.gradientMinMax.currMax=this.gradientMinMax.max,this.gradientMinMax.currMin=this.gradientMinMax.min,this.gradientMinMax.activeEl=null),this.renderPlot()},setHighlightField:function(t,e){t.target.closest(".color-key").childNodes.forEach((function(t){t.classList.remove("selected")})),this.renderConfig["color highlight"]&&this.renderConfig["color highlight"]===e?this.renderConfig["color highlight"]=null:(this.renderConfig["color highlight"]=e,t.target.closest(".anno-bubble-wrapper").classList.add("selected")),this.renderPlot()},colorGradient:function(){var t=["#450c54","#481668","#482677","#453681","#3e4788","#39558c","#31648d","#2e708e","#277d8e","#218a8d","#21968b","#20a286","#28af7f","#3dbc75","#56c667","#75d056","#94d841","#b9de28","#dce318","#fde724"],e=t,n="linear-gradient(0deg, ";return e.forEach((function(t,r){n+=t,n+=r<e.length-1?",":")"})),{width:"30px",height:"100px",background:n}},colorFromGradientByValue:function(t,e,n){var r=["#450c54","#481668","#482677","#453681","#3e4788","#39558c","#31648d","#2e708e","#277d8e","#218a8d","#21968b","#20a286","#28af7f","#3dbc75","#56c667","#75d056","#94d841","#b9de28","#dce318","#fde724"],a=n-e,i=t-e,o=i/a*100,s=Math.floor(o/100*(r.length-1));return r[s]},gradientHandleDown:function(t){t.target.classList.contains("color-gradient-handle")&&(this.gradientMinMax.activeEl=t.target,this.gradientMinMax.yOffset=t.target.getBoundingClientRect().y-t.clientY,window.addEventListener("mouseup",this.gradientHandleUp))},gradientHandleMove:function(t){if(this.gradientMinMax.activeEl){var e=this.gradientMinMax.activeEl,n=!!e.classList.contains("color-gradient-max"),r=e.closest(".color-gradient-wrapper").getBoundingClientRect(),a=t.clientY-r.top+this.gradientMinMax.yOffset;a=Math.min(Math.max(a,0),100);var i=this.gradientMinMax.max-this.gradientMinMax.min;e.dataset.val=(this.gradientMinMax.min+i*((100-a)/100)).toFixed(2),n?this.gradientMinMax.currMax=Number(e.dataset.val):this.gradientMinMax.currMin=Number(e.dataset.val),e.innerHTML=e.dataset.val,n&&(e.style.top="".concat(a+2,"px")),n||(e.style.bottom="".concat(100-a+2,"px"))}},gradientHandleUp:function(){this.gradientMinMax.activeEl&&(this.gradientMinMax.activeEl=null,window.removeEventListener("mouseup",this.gradientHandleUp),this.renderPlot())},onResize:function(t){this.renderPlot()},checkPosition:function(t,e,n){var r=this,a=e?this.posData[e]:this.posData,i=document.querySelector("#scatter_dot_value"+this.sectionId),o=document.querySelector("#scatter_dot_value_content"+this.sectionId),s=(t.target,t.target.getBoundingClientRect()),l=Math.floor(t.clientX-s.left),c=Math.floor(t.clientY-s.top),u=this.utils.plotUtils.getDotsInPos(l,c,a);if(u.length>0){var d=u.length>5&&"move"==n&&!this.isDotPanelClick?"<strong>There are more items to display. <br />Click to view the full list.</strong><br /><br />":"",h=0;if(u.map((function(t){if("move"==n&&h<6&&!r.isDotPanelClick){d+="<strong>"+t.key+"</strong><br />";for(var e=0,a=Object.entries(t.hover);e<a.length;e++){var i=Object(_["a"])(a[e],2),o=i[0],s=i[1];d+="<span>"+o+": ",d+=r.utils.Formatters.getHoverValue(s)+"</span><br />"}}else if("click"==n){d+="<strong>"+t.key+"</strong><br />";for(var l=0,c=Object.entries(t.hover);l<c.length;l++){var u=Object(_["a"])(c[l],2),p=u[0],f=u[1];d+="<span>"+p+": ",d+=r.utils.Formatters.getHoverValue(f)+"</span><br />"}}h++})),"move"==n&&!this.isDotPanelClick){o.innerHTML=d;var p=i.offsetWidth,f=i.offsetHeight,g={top:t.clientY,right:window.innerWidth-t.clientX,bottom:window.innerHeight-t.clientY,left:t.clientX}

1,m=10,v={x:g.right<p+m?-p-m:m,y:g.bottom<f+m?-f-m:m};i.style.left=g.left+v.x+"px",i.style.top=g.top+v.y+"px",i.setAttribute("class","scatter-dot-value")}"click"==n&&(this.isDotPanelClick=!0,i.setAttribute("class","scatter-dot-value fixed-panel"),o.innerHTML=d)}else"click"==n&&(this.isDotPanelClick=!1,i.setAttribute("class","scatter-dot-value hidden"),clearTimeout(this.dotPanelCloseTimer)),"move"!=n||this.isDotPanelClick||(o.innerHTML="",i.setAttribute("class","scatter-dot-value hidden"),clearTimeout(this.dotPanelCloseTimer)),"leave"==n&&(this.dotPanelCloseTimer=setTimeout((function(){r.isDotPanelClick=!1,i.setAttribute("class","scatter-dot-value hidden")}),2e3)),"enter popup"==n&&(this.isDotPanelClick=!0,clearTimeout(this.dotPanelCloseTimer))}}});s()((function(){}));var it=at,ot=(n("8135"),Object(C["a"])(it,tt,et,!1,null,null,null)),st=ot.exports,lt=n("9341"),ct=n("1203"),ut=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"mbm-plot-content 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t.downloadImage("vector_wrapper_"+t.canvasId,t.canvasId+"_barPlot","svg")}}},[t._v("Download SVG")])]),n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage(t.canvasId+"barPlot",t.canvasId+"_barPlot","png")}}},[t._v("Download PNG")])])])]),t.renderData?n("research-bar-plot-vector",{ref:t.canvasId+"_barPlot",attrs:{renderData:t.groupData(t.renderData),renderConfig:t.renderConfig,colors:t.colors,margin:t.adjPlotMargin,sectionId:t.canvasId,utils:t.utils}}):t._e()],1)])])},dt=[],ht=n("45ab"),pt=ht["a"],ft=(n("0542"),Object(C["a"])(pt,ut,dt,!1,null,null,null)),_t=ft.exports,gt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"mbm-plot-content row"},[n("div",{staticClass:"col-md-12 bar-plot-wrapper"},[n("div",{staticClass:"col-md-12",staticStyle:{display:"inline-block"},attrs:{id:t.canvasId+"barInCellPlotWrapper"}},[n("canvas",{attrs:{hidden:!t.showCanvas,id:t.canvasId+"barInCellPlot",width:"",height:""}})])])])},mt=[],vt=n("b85c"),yt=n("b300");i["default"].use(g["a"]);var bt=i["default"].component("research-bar-in-cell-plot",{props:["canvasId","plotData","plotConfig","plotMargin","utils"],data:function(){return{barData:null,barPosData:{},spaceBy:7,trigger:0,hoverItems:{},showCanvas:!0}},modules:{},components:{barPlotVector:yt["a"]},created:function(){this.renderPlot()},mounted:function(){window.addEventListener("resize",this.onResize),this.renderPlot()},beforeDestroy:function(){window.removeEventListener("resize",this.onResize)},computed:{adjPlotMargin:function(){var t=this.plotConfig["plot margin"]?this.plotConfig["plot margin"]:null,e=t?{left:t.left,right:t.right,top:t.top,bottom:t.bottom,bump:t.bump?t.bump:10}:{left:this.plotMargin.leftMargin,right:this.plotMargin.rightMargin,top:this.plotMargin.topMargin,bottom:this.plotMargin.bottomMargin,bump:this.plotMargin.bump};return e},plotGroups:function(){var t,e={xAxis:[],yAxis:[],barFields:{},barFieldsType:{},max:null,min:null},n=this.plotConfig["x axis field"],r=this.plotConfig["y axis field"],a=this.plotConfig["bars in cell"],i=Object(vt["a"])(a);try{for(i.s();!(t=i.n()).done;){var o=t.value;e.barFields[o["field"]]=o["color"],e.barFieldsType[o["field"]]=o["value type"]}}catch(s){i.e(s)}finally{i.f()}return this.plotData.map((function(t){t[n]&&(e.xAxis.includes(t[n])||e.xAxis.push(t[n])),t[r]&&(e.yAxis.includes(t[r])||e.yAxis.push(t[r])),Object.keys(e.barFields).map((function(n){var r=t[n];e.max=r&&(!e.max||e.max<r)?r:e.max,e.min=r&&(!e.min||e.min>r)?r:e.min}))})),e.min=e.min>0?0:e.min,e},renderData:function(){return this.plotData}},watch:{renderData:function(t){this.renderPlot()}},methods:{onResize:function(){this.renderPlot()},renderPlot:function(){var t=document.querySelector("#"+this.canvasId+"barInCellPlotWrapper"),e=document.querySelector("#"+this.canvasId+"barInCellPlot"),n=this.adjPlotMargin,r=this.plotGroups,a=this.plotConfig,i=a["bar width"],o=a["bar height"],s=i*Object.keys(r.barFields).length+n.bump,l=o+n.bump,c=i/r.max,u=2*n.left+n.bump,d=2*n.top+n.bump;if(e&&t){var h,p=2*(n.left+n.right+r.xAxis.length*s),f=2*(n.top+n.bottom+r.yAxis.length*l);e.setAttribute("width",p),e.setAttribute("height",f),e.setAttribute("style","width:"+p/2+"px;

1height:"+f/2+"px;"),h=e.getContext("2d");var _=function(t,e,n){return h.font=e+"px "+n,h.measureText(t).width};h.clearRect(0,0,p,f),this.barPosData={};var g=2*n.bump;Object.keys(r.barFields).map((function(t){h.fillStyle=r.barFields[t],h.fillRect(g,2*n.bump,24,24),g+=24+n.bump,h.textAlign="start",h.font="26px Arial",h.fillStyle="#000000",h.fillText(t,g,2*n.bump+24),g+=_(t,26,"Arial")+2*n.bump})),h.font="26px Arial",h.fillStyle="#000000",r.yAxis.map((function(t,e){var a=d+2*l*e;h.textAlign="end",h.fillText(t,2*n.left-n.bump/2,a+(2*o-n.bump)),h.moveTo(u-n.bump/2+2*s*e,d-n.bump/2),h.lineTo(u-n.bump/2+2*s*e,d+(r.yAxis.length*(2*l)-n.bump/2)),h.strokeStyle="#666666",h.lineWidth=1,h.stroke()})),r.xAxis.map((function(t,e){h.textAlign="center",h.fillText(t,2*n.left+2*s*(e+1)-s,2*n.top-n.bump)}));var m=c*r.max*2;r.xAxis.map((function(t,e){r.yAxis.map((function(t,n){Object.keys(r.barFields).map((function(t,r){var a=d+2*l*n,c=u+2*s*e+2*i*r;h.fillStyle="#999999",h.fillRect(c,a+o,m,2)}))}))})),this.plotData.map((function(t){var e=r.xAxis.indexOf(t[a["x axis field"]]),p=r.yAxis.indexOf(t[a["y axis field"]]);Object.keys(r.barFields).map((function(a,f){var g=d+2*l*p,v=u+2*s*e+2*i*f,y=c*t[a]*2;if(h.fillStyle="#ffffff",h.fillRect(v,g,m,2*o),"number"==r.barFieldsType[a]){h.fillStyle="#eeeeee",h.fillRect(v,g,m,2*o),h.fillStyle=r.barFields[a],h.fillRect(v,g,y,2*o);var b=_(t[a],26,"Arial");b+y>m?(h.textAlign="end",h.fillStyle="#ffffff",h.fillText(t[a],v+y-n.bump,g+(2*o-n.bump))):(h.textAlign="start",h.fillStyle="#000000",h.fillText(t[a],v+y+n.bump,g+(2*o-n.bump)))}else"string"==r.barFieldsType[a]&&(h.textAlign="start",h.fillStyle=r.barFields[a],h.fillText(t[a],v+n.bump,g+(2*o-n.bump)))}))})),h.textAlign="center",h.font="700 30px Arial",h.fillStyle="#000000",h.fillText(a.label,p/2,f-n.bump)}}}});s()((function(){}));var xt=bt,wt=Object(C["a"])(xt,gt,mt,!1,null,null,null),Ct=wt.exports,Pt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"mbm-plot-content row"},[n("div",{staticClass:"col-md-12 box-plot-wrapper"},[n("div",{staticClass:"col-md-12",staticStyle:{display:"inline-block"},attrs:{id:t.canvasId+"boxPlotWrapper"}},[n("div",{staticClass:"boxplot-info-box hidden",attrs:{id:t.canvasId+"boxInfoBox"}},[n("div",{staticClass:"fixed-info-box-close",attrs:{id:t.canvasId+"info_box_close"},on:{click:function(e){return t.utils.uiUtils.removeOnMouseOut(t.canvasId+"boxInfoBox",100)}}},[n("b-icon",{attrs:{icon:"x-circle-fill"}})],1),n("span",{attrs:{id:t.canvasId+"boxInfoBoxContent"}}),t._l(t.hoverItems,(function(e,r){return n("span",{key:r},[n("strong",[t._v(t._s(r))]),n("br"),t._l(e.data,(function(e,r){return n("span",[n("span",[t._v(t._s(r+": "))]),n("span",[t._v(t._s(e))]),t._v(" "),n("br")])})),null!=t.options&&1==t.utils.uiUtils.isIdFixed("#"+t.canvasId+"boxInfoBox")?[t.options.includes("add phenotype")?n("button",{staticClass:"option-button",on:{click:function(n){return t.addPhenotype(e.id)}}},[t._v(" Add this phenotype below ")]):t._e(),t.options.includes("open phenotype page")?n("button",{staticClass:"option-button",on:{click:function(n){return t.openPage("phenotype.html",{phenotype:e.id})}}},[t._v(" Go to phenotype page ")]):t._e()]:t._e(),null!=t.options&&0==t.utils.uiUtils.isIdFixed("#"+t.canvasId+"boxInfoBox")?n("span",[t._v("Click for options")]):t._e()],2)}))],2),n("div"),n("canvas",{attrs:{hidden:!t.showCanvas,id:t.canvasId+"boxPlot",width:"",height:""},on:{mousemove:function(e){return t.checkPosition(e,"hover")},click:function(e){return t.checkPosition(e,"click")},mouseout:function(e){!t.utils.uiUtils.isIdFixed("#"+t.canvasId+"boxInfoBox")&&t.utils.uiUtils.removeOnMouseOut(t.canvasId+"boxInfoBox",1e3)}}}),n("div",{staticClass:"download-images-setting"},[n("span",{staticClass:"btn btn-default options-gear"},[t._v("Download "),n("b-icon",{attrs:{icon:"download"}})],1),n("ul",{staticClass:"options"},[n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage("vector_wrapper_"+t.canvasId,t.canvasId+"_boxPlot","svg")}}},[t._v("Download SVG")])]),n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage(t.canvasId+"boxPlot",t.canvasId+"_boxPlot","png")}}},[t._v("Download PNG")])])])]),t.renderData?n("research-box-plot-vector",{ref:t.canvasId+"_boxPlot",attrs:{renderData:t.groupData(t.renderData),renderConfig:t.renderConfig,colors:t.colors,margin:t.adjPlotMargin,sectionId:t.canvasId,utils:t.utils}}):t._e()],1)])])},kt=[],Mt=n("c1fa"),Et=Mt["a"],Dt=(n("a7ad"),Object(C["a"])(Et,Pt,kt,!1,null,null,null)),Ot=Dt.exports,Lt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{staticClass:"region-track-wrapper",attrs:{id:"region_track_wrapper"+t.sectionId}},[n("div",{staticClass:"block-data hidden",attrs:{id:"block_data_"+t.sectionId}},[n("div",{staticClass:"fixed-info-box-close",on:{click:function(e){t.infoBoxFrozen=!1,t.hidePanel("block_data_"+t.sectionId)}}},[n("b-icon",{attrs:{icon:"x-circle-fill"}}

1)],1),n("div",{staticClass:"block-data-content",attrs:{id:"block_data_content_"+t.sectionId}},[t._l(t.infoBoxContent.data,(function(e,r){return["hover"==t.infoBoxContent.action&&r<5?n("span",[n("strong",[t._v(t._s(e.title))]),t._l(e,(function(e,r){return["title"!=r?n("span",[n("br"),t._v(t._s(r+": "+e))]):t._e()]})),t.plotConfig["set region parameter by"]&&e[t.plotConfig["set region parameter by"]["field"]]?[n("br"),n("span",{staticStyle:{color:"#5fa331"}},[t._v("Click to set region.")])]:t._e(),n("br")],2):t._e(),"click"==t.infoBoxContent.action?n("span",[n("strong",[t._v(t._s(e.title))]),t._l(e,(function(e,r){return["title"!=r?n("span",[n("br"),t._v(t._s(r+": "+e))]):t._e()]})),t.plotConfig["set region parameter by"]&&e[t.plotConfig["set region parameter by"]["field"]]?[n("br"),n("button",{staticClass:"btn btn-primary btn-sm",on:{click:function(n){return t.setRegion(e[t.plotConfig["set region parameter by"]["field"]],t.plotConfig["set region parameter by"]["parameter"],t.plotConfig["set region parameter by"]["max region"])}}},[t._v(" Set region ")]),n("br"),t._v("Max length: "+t._s(t.plotConfig["set region parameter by"]["max region"])+" ")]:t._e(),n("br")],2):t._e(),t.infoBoxContent.data.length>1?[n("br"),n("br")]:t._e()]}))],2)]),n("div",{staticClass:"col-md-11"},t._l(t.colorGroups,(function(e,r){return n("span",{key:e,staticClass:"color-groups",on:{mouseover:function(n){return t.renderPlot(e)},mouseleave:function(e){return t.renderPlot()}}},[n("span",{staticClass:"box",style:"background-color:"+t.colors.bold[r%16]}),n("span",{staticClass:"label",domProps:{innerHTML:t._s(e)}})])})),0),t.plotConfig?n("canvas",{staticClass:"region-track",attrs:{id:"track_"+t.sectionId,width:"",height:""},on:{mouseleave:function(e){t.hidePanel("block_data_"+t.sectionId),t.resetPosMarker()},mousemove:function(e){return t.checkPosition(e,"hover")},click:function(e){return t.checkPosition(e,"click")},resize:t.onResize}}):t._e(),n("span",{staticClass:"x-pos-marker",attrs:{id:t.sectionId+"_xPosMarker"}}),n("div",{staticClass:"download-images-setting"},[n("span",{staticClass:"btn btn-default options-gear"},[t._v("Download "),n("b-icon",{attrs:{icon:"download"}})],1),n("ul",{staticClass:"options"},[n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage("vector_wrapper_"+t.sectionId,t.sectionId+"_regionTrack","svg")}}},[t._v("Download SVG")])]),n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage("track_"+t.sectionId,t.sectionId+"_regionTrack","png")}}},[t._v("Download PNG")])])])]),t.renderData?n("research-region-track-vector",{ref:t.sectionId+"_regionTrack",attrs:{renderData:t.renderData,renderConfig:t.plotConfig,colors:t.colors.bold,margin:t.adjPlotMargin,region:t.viewingRegion,sectionId:t.sectionId,utils:t.utils}}):t._e()],1)},jt=[],St=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",[n("div",{class:"vector-wrapper-"+t.canvasId,attrs:{id:"vector_wrapper_"+t.sectionId}})])},At=[];n("07ac");i["default"].use(g["a"]);var It=i["default"].component("research-region-track-vector",{props:["renderData","renderConfig","colors","margin","region","sectionId","utils"],data:function(){return{}},modules:{},components:{},created:function(){},mounted:function(){},beforeDestroy:function(){},computed:{canvasId:function(){var t=this.sectionId.replaceAll("_","-").toLowerCase();return t}},watch:{canvasId:function(t){}},methods:{renderPlot:function(){var t=this,e=".vector-wrapper-".concat(this.canvasId),n=document.createElement("canvas"),r=n.getContext("2d"),a=function(t,e,n){return r.font=e+"px "+n,r.measureText(t).width},i=document.querySelector("#region_track_wrapper"+this.sectionId),o={left:this.margin.left/2,right:this.margin.right/2,top:this.margin.top/2,bottom:this.margin.bottom/2,bump:this.margin.bump/2},s=Object.keys(this.renderData).sort(),l=[];Object.values(this.renderData).map((function(e){Object.values(e).map((function(e){e.map((function(e){l.push(e[t.renderConfig["color by"]])}))}))})),l=Object(f["a"])(new Set(l)).sort();var c=0;l.map((function(t){return c+=a(t,12,"Arial")+20}));var u=this.renderConfig["width"]?this.renderConfig["width"]:i.clientWidth-(o.left+o.right),d=Math.ceil((20*l.length+c)/u);o.top=o.top+20*d;var h=this.renderConfig["track height"]*s.length,p=b["select"](e).append("svg").attr("id","vector_region_track_"+this.sectionId).attr("width",u+o.left+o.right).attr("height",h+o.top+o.bottom);p.append("g").attr("id","tracksGroup").attr("transform","translate(0,0)").style("font-family","Arial").style("font-size",12).style("text-anchor","start");var _=o.bump,g=20;l.map((function(e,n){var r=t.renderConfig["color by"]?n%t.colors.length:null,i=r||0===r?t.colors[r]:"#00000066";p.select("#tracksGroup").append("rect").attr("x",_).attr("y",g-12).attr("height",12).attr("width",12).style("fill",i);var s=a(e,12,"Arial");p.select("#tracksGroup").append("text").attr("x",_+15).attr("y",g).text(e),s+=a(l[n+1],12,"Arial"),_+s+20>u+o.left?(_=o.bump,g+=20):_+=a(e,12,"Arial")+20}));var m=b["scaleLinear"]().domain([this.region.start,this.region.end]).range([o.left,u+o.left]);p.select("#tracksGroup").append("line").attr("x1",o.left-o.bump).attr("y1",o.top+h+o.bump).attr("x2",o.left+u+o.bump).attr("y2",o.top+h+o.bump).attr("stroke","#000000").style("stroke-width",.7

15);for(var v=Math.ceil((this.region.end-this.region.start)/5),y=0;y<6;y++){var x=m(this.region.start+v*y);p.select("#tracksGroup").append("line").attr("x1",x).attr("y1",o.top+h+o.bump).attr("x2",x).attr("y2",o.top+h+2*o.bump).attr("stroke","#000000").style("stroke-width",.75);var w=this.region.end-this.region.start,C=w<=1?2:w<=50?1:0,P=this.utils.Formatters.decimalFormatter(this.region.start+y*v,C);P=P>=1e5?Math.round(.001*P)+"k":P,p.select("#tracksGroup").append("text").attr("x",x).attr("y",o.top+h+20).style("text-anchor","middle").text(P)}p.select("#tracksGroup").append("line").attr("x1",o.left-o.bump).attr("y1",o.top).attr("x2",o.left-o.bump).attr("y2",o.top+h+o.bump).attr("stroke","#000000").style("stroke-width",.75),p.select("#tracksGroup").append("line").attr("x1",o.left+u+o.bump).attr("y1",o.top).attr("x2",o.left+u+o.bump).attr("y2",o.top+h+o.bump).attr("stroke","#000000").style("stroke-width",.75),s.map((function(e,n){var r="",i=a(e,12,"Arial");if(i>o.left-o.bump){for(var s=0;s<e.length;s++)a(r+e[s],12,"Arial")<o.left-6*o.bump&&(r+=e[s]);r+="..."}else r=e;p.select("#tracksGroup").append("text").attr("x",o.bump).attr("y",n*t.renderConfig["track height"]+o.top+10).text(r),n%2==0&&p.select("#tracksGroup").append("rect").attr("x",o.left).attr("y",n*t.renderConfig["track height"]+o.top).attr("height",t.renderConfig["track height"]).attr("width",u).style("fill","#eeeeee"),Object.keys(t.renderData[e]).map((function(r){var a=r.split("-"),i=m(a[0])<m(t.region.start)?m(t.region.start):m(a[0]),s=m(a[1])>m(t.region.end)?m(t.region.end):m(a[1]),c=s-i<1?1:s-i;t.renderData[e][r].map((function(e){var r=t.renderConfig["color by"]?l.indexOf(e[t.renderConfig["color by"]])%t.colors.length:null,a=r||0===r?t.colors[r]:"#00000066";p.select("#tracksGroup").append("rect").attr("x",i).attr("y",n*t.renderConfig["track height"]+o.top).attr("height",t.renderConfig["track height"]).attr("width",c).style("fill",a)}))}))}))}}});s()((function(){}));var Tt=It,Bt=Object(C["a"])(Tt,St,At,!1,null,null,null),Rt=Bt.exports;n("6e0f");i["default"].use(g["a"]);var Ft=i["default"].component("research-region-track",{props:["sectionId","plotConfig","plotData","dataComparisonConfig","regionParam","regionZoom","regionViewArea","colors","utils","plotMargin","starItems"],data:function(){return{posData:{},groupsList:null,colorGroups:[],infoBoxFrozen:!1,starGroups:[],infoBoxContent:{action:null,data:[]}}},modules:{},components:{regionTrackVector:Rt},mounted:function(){this.renderPlot(),window.addEventListener("resize",this.onResize)},beforeDestroy:function(){window.removeEventListener("resize",this.onResize)},computed:{hoverPos:function(){return this.$root.hoverPos},region:function(){var t=this.regionParam;if(this.plotConfig["expand region by"]){var e=t.split(":"),n=e[0],r=e[1].split("-"),a=Number(r[0]),i=Number(r[1]);a-=this.plotConfig["expand region by"]/2,a=a<=0?0:a,i+=this.plotConfig["expand region by"]/2,t=n+":"+a+"-"+i}return t},adjPlotMargin:function(){var t=this.plotConfig["plot margin"]?this.plotConfig["plot margin"]:null,e=t?{left:t.left,right:t.right,top:t.top,bottom:t.bottom,bump:t.bump?t.bump:10}:{left:this.plotMargin.leftMargin,right:this.plotMargin.rightMargin,top:this.plotMargin.topMargin,bottom:this.plotMargin.bottomMargin,bump:this.plotMargin.bump};return e},viewingRegion:function(){if(null==this.region)return null;var t={};t["chr"]=parseInt(this.region.split(":")[0],10);var e=this.region.split(":")[1].split("-"),n=this.region.split(":")[0],r=parseInt(e[0],10),a=parseInt(e[1],10),i=a-r;if(this.regionZoom>0){var o=Math.round(i*(this.regionZoom/200)),s=Math.round(o*(this.regionViewArea/100));t["chr"]=n,t["start"]=r+o+s,t["end"]=a-o+s}else 0==this.regionZoom&&(t["chr"]=n,t["start"]=r,t["end"]=a);return t},renderData:function(){var t=this,e={},n=[];return this.plotData.map((function(r){e[r[t.plotConfig["y axis field"]]]||(e[r[t.plotConfig["y axis field"]]]={}),t.plotConfig["color by"]&&!n.includes(r[t.plotConfig["color by"]])&&n.push(r[t.plotConfig["color by"]]),e[r[t.plotConfig["y axis field"]]][r[t.plotConfig["render by"]]]||(e[r[t.plotConfig["y axis field"]]][r[t.plotConfig["render by"]]]=[]),e[r[t.plotConfig["y axis field"]]][r[t.plotConfig["render by"]]].push(r)})),this.colorGroups=n.sort(),e}},watch:{hoverPos:function(t){this.renderPlot(null,"enter")},viewingRegion:function(t){this.renderPlot()},plotData:function(t){this.renderPlot()},starItems:function(t){this.starGroups=Object(f["a"])(new Set(t.map((function(t){return t.section})))).sort(),this.renderPlot()}},methods:{setRegion:function(t,e,n){var r=t.split(":"),a=r[1].split("-"),i=Math.floor(Number(a[0])+(a[1]-a[0])/2),o=i-n/2<=0?0:Math.floor(i-n/2),s=Math.floor(i+n/2),l=r[0]+":"+o+"-"+s,c=window.location.href.split("?"),u=c[1].split("&"),d="?";u.map((function(t,n){var r=t.split("=");d+=r[0]==e?r[0]+"="+l:r[0]+"="+r[1],d+=n<u.length-1?"&":""})),window.location.href=c[0]+d},downloadImage:function(t,e,n){"svg"==n?(this.$refs[this.sectionId+"_regionTrack"].renderPlot(),this.utils.uiUtils.downloadImg(t,e,n,"vector_region_track_"+this.sectionId)):"png"==n&&this.utils.uiUtils.downloadImg(t,e,n)},renderPlot:function(t,e){var n=this;this.posData={};var r,a,i=Object.keys(this.renderData).sort(),o=2*this.plotConfig["track height"],s=2*document.querySelector("#regi

1on_track_wrapper"+this.sectionId).clientWidth,l=o*i.length+this.adjPlotMargin.top+this.adjPlotMargin.bottom;r=document.getElementById("track_"+this.sectionId),r.setAttribute("width",s),r.setAttribute("height",l),r.setAttribute("style","width: "+s/2+"px;height:"+l/2+"px;"),a=r.getContext("2d"),a.clearRect(0,0,s,l);var c=0,u=o*i.length,d=s-(this.adjPlotMargin.left+this.adjPlotMargin.right),h=this.viewingRegion,p=d/(h.end-h.start);a.fillStyle="#ff880025",a.fillRect(this.adjPlotMargin.left,u+this.adjPlotMargin.top+2*this.adjPlotMargin.bump+12,d,12),this.renderAxis(a,d,u,Number(h.end),Number(h.start),this.adjPlotMargin.top,this.adjPlotMargin);var f=document.createElement("canvas"),_=f.getContext("2d"),g=function(t,e,n){return _.font=e+"px "+n,_.measureText(t).width};i.map((function(e){var r=n.adjPlotMargin.top+o*c;a.fillStyle="#000000",a.textAlign="start",a.textBaseline="middle",a.font="24px Arial";Math.floor((n.adjPlotMargin.left-n.adjPlotMargin.bump)/16);var i="",s=g(e,24,"Arial");if(s>n.adjPlotMargin.left-n.adjPlotMargin.bump){for(var l=0;l<e.length;l++)g(i+e[l],24,"Arial")<n.adjPlotMargin.left-6*n.adjPlotMargin.bump&&(i+=e[l]);i+="..."}else i=e;a.fillText(i,2,r+12),c%2==0&&(a.fillStyle="#00000010",a.fillRect(n.adjPlotMargin.left,r,d,o));var u=n.renderData[e],f=Object.keys(u);f.map((function(i){u[i].map((function(i,s){var l,c,u,f=i[n.plotConfig["render by"]].split("-"),_=f[0],g=f[1];_<=h.end&&g>=h.start?(l=(_-h.start)*p+n.adjPlotMargin.left,l=l<=n.adjPlotMargin.left?n.adjPlotMargin.left:l,c=(g-h.start)*p+n.adjPlotMargin.left,c=c>n.adjPlotMargin.left+d?n.adjPlotMargin.left+d:c):_<=h.start&&g>=h.start?(l=n.adjPlotMargin.left-n.adjPlotMargin.bump,c=(g-h.start)*p+n.adjPlotMargin.left,c=c>n.adjPlotMargin.left+d?n.adjPlotMargin.left+d:c):_<=h.end&&g>=h.end?(l=(_-h.start)*p+n.adjPlotMargin.left,l=l<=n.adjPlotMargin.left?n.adjPlotMargin.left:l,c=n.adjPlotMargin.left+d+n.adjPlotMargin.bump):g<=h.start?(l=n.adjPlotMargin.left-n.adjPlotMargin.bump-15,c=n.adjPlotMargin.left-n.adjPlotMargin.bump-5):_>=h.end&&(l=n.adjPlotMargin.left+d+n.adjPlotMargin.bump+5,c=n.adjPlotMargin.left+d+n.adjPlotMargin.bump+15),u=c-l<2?2:c-l;var m=n.plotConfig["color by"]?n.colorGroups.indexOf(i[n.plotConfig["color by"]])%16:null,v=!(!t||i[n.plotConfig["color by"]]!=t)||null;v&&(a.fillStyle="#FF0000",a.fillRect(l-2,r-2,u+4,o+4)),a.fillStyle=m||0===m?n.colors.bold[m]:"#00000066",a.fillRect(l,r,u,o),n.posData[Math.round(r/2)]||(n.posData[Math.round(r/2)]={label:e,regions:[]}),n.posData[Math.round(r/2)]["regions"].push({start:Math.round(l/2),end:Math.round((l+u)/2),data:i})}))})),c++}));var m=this.adjPlotMargin.left;if(this.starItems){var v=this.adjPlotMargin.top-this.adjPlotMargin.bump,y=this.adjPlotMargin.top+u+3*this.adjPlotMargin.bump;this.starItems.map((function(t){var e=m+(t.columns[n.plotConfig["x axis field"]]-h.start)*p,r=n.colors.moderate[n.starGroups.indexOf(t.section)%16];n.utils.plotUtils.renderDashedLine(a,e,v,e,y,3,r,[6,2])}));var b=this.adjPlotMargin.bump;this.starGroups.map((function(t,e){var r=n.colors.bold[e],i=n.adjPlotMargin.top+u+n.adjPlotMargin.bottom-n.adjPlotMargin.bump;n.utils.plotUtils.renderDashedLine(a,b,i,b+50,i,3,r,[12,4]),b+=60,a.font="24px Arial",a.fillStyle=r,a.fillText(t,b,i),b+=g(t,24,"Arial")+n.adjPlotMargin.bump}))}if(this.hoverPos.length>0&&this.hoverPos.map((function(t){var e=n.adjPlotMargin.top-n.adjPlotMargin.bump,r=n.adjPlotMargin.top+u+3*n.adjPlotMargin.bump,i=m+(t-h.start)*p;n.utils.plotUtils.renderDashedLine(a,i,e,i,r,1,"#ff0000",[6,2])})),this.plotConfig["expand region by"]){var x=this.regionParam.split(":")[1].split("-"),w=this.adjPlotMargin.top+u+this.adjPlotMargin.bump/2,C=m+(x[0]-h.start)*p,P=m+(x[1]-h.start)*p,k=P-C;a.fillStyle="#FF0000",a.fillRect(C,w,k,10),a.font="24px Arial",a.fillStyle="#ff0000",a.textAlign="center",a.fillText("Viewing region",C+k/2,w+3*this.adjPlotMargin.bump)}},renderAxis:function(t,e,n,r,a,i,o){t.beginPath(),t.lineWidth=1,t.strokeStyle="#000000",t.setLineDash([]),t.moveTo(this.adjPlotMargin.left-this.adjPlotMargin.bump,i),t.lineTo(this.adjPlotMargin.left-this.adjPlotMargin.bump,i+n+this.adjPlotMargin.bump),t.stroke();var s=Math.round(this.adjPlotMargin.left+e+this.adjPlotMargin.bump);t.moveTo(s,i),t.lineTo(s,i+n+this.adjPlotMargin.bump),t.stroke(),t.moveTo(this.adjPlotMargin.left-this.adjPlotMargin.bump,i+n+this.adjPlotMargin.bump),t.lineTo(s,i+n+this.adjPlotMargin.bump),t.stroke();for(var l=Math.ceil((r-a)/5),c=e/5,u=0;u<6;u++){var d=this.adjPlotMargin.left+u*c,h=Math.floor(d);t.moveTo(h,i+n+this.adjPlotMargin.bump),t.lineTo(h,i+n+2*this.adjPlotMargin.bump),t.stroke(),t.textAlign="center",t.font="24px Arial",t.fillStyle="#000000";var p=r-a,f=p<=1?2:p<=50?1:0,_=this.utils.Formatters.decimalFormatter(a+u*l,f);_=_>=1e5?Math.round(.001*_)+"k":_,t.fillText(_,h,i+n+36+this.adjPlotMargin.bump)}},resetPosMarker:function(){var t=document.getElementById(this.sectionId+"_xPosMarker");t.style.left="0px",t.style.top="0px",t.style.height="1px"},checkPosition:function(t,e){var n=this,r=t.target.getBoundingClientRect(),a=Math.floor(t.clientX-r.left),i=Math.floor(t.clientY-r.top),o=document.getElementById("region_track_wrapper"+this.sectionId).getBoundingClientRect();if(this.getPosInfo(a,i,e),"hover"==e&&a>=this.adjPlotMargin.left/2&&a<=r.width-this.adjPlotMargin.right/2&&i>=r.height-this.adjPlotMargin.bottom/2){var s=document.getElementById(this.sectionId+"_xPosMarker");s.style.left=a+"px",s.style.top=o.height-r.height+"px",s.style.height=r.height-this.adjPlotMargin.bottom/2+"px"}else this.resetPosMarker();if("click"==e&&a>=this.adjPlotMargin.left/2&&a<=r.width-this.adjPlotMargin.right/2&&i>=r.height-this.adjPlotMargin.bottom/2){var l=r.width-(this.adjPlotMargin.left/2+this.adjPlotMargin.right/2),c=a-this.adjPlotMargin.left/2,u=this.convertXPos(c,l),d=!1,h=[];this.hoverPos.length>0&&(this.hoverPos.map((function(t){var e=2*Math.floor((n.viewingRegion.end-n.viewingRegion.start)/l);t>=u-e&&t<=u+e?d=!0:h.push(t)})),this.$root.hoverPos=h),d||this.$root.hoverPos.push(Math.floor(u))}},convertXPos:function(t,e){var n=(this.viewingRegion.end-this.viewingRegion.start)/e,r=t*n+this.viewingRegion.start;return r},getPosInfo:function(t,e,n){var r=this;if(0==this.infoBoxFrozen){var a=document.getElementById("block_data_"+this.sectionId),i=(document.getElementById("block_data_content_"+this.sectionId),document.getElementById("track_"+this.sectionId));"click"==n&&a.setAttribute("style","");var o=Object.keys(this.posData),s=[],l="";if(o.map((function(n){var a=Number(n),i=a+Math.round(r.plotConfig["track height"]);e>=a&&e<=i&&(l=r.posData[n].label,r.posData[n]["regions"].map((function(e){t>=e.start&&t<=e.end&&s.push(e.data)})))})),s.length>0||""!=l){"click"==n&&(this.infoBoxFrozen=!0,document.getElementById("block_data_"+this.sectionId).classList.add("fixed-info-box"));var c=[];if(s.map((function(t){var e={};e["title"]=t[r.plotConfig["render by"]],r.plotConfig["hover content"].map((function(n){e[n]=r.utils.Formatters.getHoverValue(t[n])})),c.push(e)})),this.infoBoxContent.action=n,this.infoBoxContent.data=c.length>0?c:[{title:l}],"hover"==n){a.classList.remove("hidden"),a.classList.add("hover"),a.style.top=e+i.offsetTop+25+"px";var u=t/i.offsetWidth;a.style.left=t-a.offsetWidth*u+i.offsetLeft+"px",document.getElementById("block_data_"+this.sectionId).classList.remove("fixed-info-box"),document.getElementById("track_"+this.sectionId).classList.add("hover")}else a.classList.remove("hover")}else(n=0==this.infoBoxFrozen)&&(a.classList.add("hidden"),document.getElementById("track_"+this.sectionId).classList.remove("hover"))}},onResize:function(t){this.renderPlot()},hidePanel:function(t){0==this.infoBoxFrozen&&this.utils.uiUtils.hideElement(t)}}});s()((function(){}));var Gt=Ft,Wt=(n("ecb6"),Object(C["a"])(Gt,Lt,jt,!1,null,null,null)),Ut=Wt.exp

1orts,qt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",[n("div",{staticClass:"region-track-wrapper",attrs:{id:"region_track_wrapper"+t.sectionId}},[n("div",{staticClass:"block-data hidden",attrs:{id:"block_data_"+t.sectionId}},[n("div",{staticClass:"fixed-info-box-close",on:{click:function(e){t.infoBoxFrozen=!1,t.hidePanel("block_data_"+t.sectionId)}}},[n("b-icon",{attrs:{icon:"x-circle-fill"}})],1),n("div",{staticClass:"block-data-content",attrs:{id:"block_data_content_"+t.sectionId}})]),n("div",t._l(t.colorGroups,(function(e,r){return n("span",{key:e,staticClass:"color-groups",on:{mouseover:function(n){return t.renderPlot(e)},mouseleave:function(e){return t.renderPlot()}}},[n("span",{staticClass:"box",style:"background-color:"+t.colors.bold[r%16]}),n("span",{staticClass:"label",domProps:{innerHTML:t._s(e)}})])})),0),t.plotConfig?n("canvas",{staticClass:"region-track",attrs:{id:"track_"+t.sectionId,width:"",height:""},on:{mouseleave:function(e){return t.hidePanel("block_data_"+t.sectionId)},mousemove:function(e){return t.checkPosition(e,"hover")},click:function(e){return t.checkPosition(e,"click")},resize:t.onResize}}):t._e(),n("div",{staticClass:"download-images-setting"},[n("span",{staticClass:"btn btn-default options-gear"},[t._v("Download "),n("b-icon",{attrs:{icon:"download"}})],1),n("ul",{staticClass:"options"},[n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage("vector_wrapper_"+t.sectionId,t.sectionId+"_regionDots","svg")}}},[t._v("Download SVG")])]),n("li",[n("a",{attrs:{href:"javascript:;"},on:{click:function(e){return t.downloadImage("track_"+t.sectionId,t.sectionId+"_regionDots","png")}}},[t._v("Download PNG")])])])]),t.plotData?n("research-region-dots-vector",{ref:t.sectionId+"_regionDots",attrs:{renderData:t.renderData,renderConfig:t.plotConfig,colorGroups:t.colorGroups,colors:t.colors,margin:t.adjPlotMargin,region:t.viewingRegion,sectionId:t.sectionId,utils:t.utils}}):t._e()],1)])},Nt=[],Kt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",[n("div",{class:"vector-wrapper-"+t.sectionId,attrs:{id:"vector_wrapper_"+t.sectionId}})])},Vt=[];i["default"].use(g["a"]);var zt=i["default"].component("research-region-dots-vector",{props:["renderData","colorGroups","renderConfig","colors","margin","region","sectionId","utils"],data:function(){return{}},modules:{},components:{},created:function(){},mounted:function(){},beforeDestroy:function(){},computed:{canvasId:function(){var t=this.sectionId.replaceAll("_","-").toLowerCase();return t}},watch:{canvasId:function(t){}},methods:{renderPlot:function(){var t=this,e=document.createElement("canvas"),n=e.getContext("2d"),r=function(t,e,r){return n.font=e+"px "+r,n.measureText(t).width},a={left:this.margin.left/2,right:this.margin.right/2,top:this.margin.top/2,bottom:this.margin.bottom/2,bump:this.margin.bump/2},i=".vector-wrapper-".concat(this.sectionId),o=document.querySelector("#region_track_wrapper"+this.sectionId),s=0;this.colorGroups.map((function(t){return s+=r(t,12,"Arial")+20}));var l=this.renderConfig["width"]?this.renderConfig["width"]:o.clientWidth-(a.left+a.right),c=Math.ceil((20*this.colorGroups.length+s)/l);a.top=a.top+20*c;var u=this.renderConfig["track height"]?this.renderConfig["track height"]:200,d=b["select"](i).append("svg").attr("id","vector_region_dots_"+this.sectionId).attr("width",l+a.left+a.right).attr("height",u+a.top+a.bottom);d.append("g").attr("id","plot").attr("transform","translate(0,0)");var h=a.bump,p=20;this.colorGroups.map((function(e,n){var i=t.renderConfig["color by"]?n%t.colors.moderate.length:null,o=i||0===i?t.colors.moderate[i]:"#00000066";d.select("#plot").append("rect").attr("x",h).attr("y",p-12).attr("height",12).attr("width",12).style("fill",o);var s=r(e,12,"Arial");d.select("#plot").append("text").attr("x",h+15).attr("y",p).style("text-anchor","start").text(e),s+=r(t.colorGroups[n+1],12,"Arial"),h+s+20>l+a.left?(h=a.bump,p+=20):h+=r(e,12,"Arial")+20})),d.select("#plot").style("font-family","Arial").style("font-size","12px").style("text-anchor","middle"),d.select("#plot").append("text").attr("transform","translate("+(a.bump+20)+","+(a.top+u/2)+")rotate(-90)").attr("x",0).attr("y",0).text(this.renderConfig["y axis label"]);var f=b["scaleLinear"]().domain([this.region.start,this.region.end]).range([a.left,l+a.left]);d.select("#plot").append("line").attr("x1",a.left-a.bump).attr("y1",a.top+u+a.bump).attr("x2",a.left+l+a.bump).attr("y2",a.top+u+a.bump).attr("stroke","#000000").style("stroke-width",.7

15);for(var _=Math.ceil((this.region.end-this.region.start)/5),g=0;g<6;g++){var m=f(this.region.start+_*g);d.select("#plot").append("line").attr("x1",m).attr("y1",a.top+u+a.bump).attr("x2",m).attr("y2",a.top+u+2*a.bump);var v=this.region.end-this.region.start,y=v<=1?2:v<=50?1:0,x=this.utils.Formatters.decimalFormatter(this.region.start+g*_,y);x=x>=1e5?Math.round(.001*x)+"k":x,d.select("#plot").append("text").attr("x",m).attr("y",a.top+u+20).style("text-anchor","middle").text(x)}for(var w=this.renderConfig["x axis field"],C=this.renderConfig["y axis field"],P=this.renderData.high,k=this.renderData.low,M=(P-k)/2,E=[],D=0;D<3;D++){var O=P-k,L=O<=1?2:O<=50?1:0,j=this.utils.Formatters.decimalFormatter(P-D*M,L);j=j>=1e5?Math.round(.001*j)+"k":j,E.push(j)}k=Number(E[2]),P=Number(E[0]);var S=b["scaleLinear"]().domain([k,P]).range([a.top+u,a.top]);d.select("#plot").append("g").attr("transform","translate("+(a.left-a.bump)+",0)").call(b["axisLeft"](S).ticks(2)),this.colorGroups.map((function(e,n){var r=t.renderData.data.filter((function(n){return n[t.renderConfig["color by"]]===e})),a=n%t.colors.moderate.length,i=a||0===a?t.colors.moderate[a]:"#00000066";r.map((function(e,n){var r=e[w],a=e[C];if(r>=t.region.start&&r<=t.region.end&&a){var o=f(r),s=S(a);d.select("#plot").append("circle").attr("cx",o).attr("cy",s).attr("r",5).style("fill",i)}}))}))}}});s()((function(){}));var $t=zt,Ht=Object(C["a"])($t,Kt,Vt,!1,null,null,null),Yt=Ht.exports;i["default"].use(g["a"]);var Zt=i["default"].component("research-region-dots-track",{props:["sectionId","plotConfig","plotData","dataComparisonConfig","region","regionZoom","regionViewArea","colors","utils","plotMargin","starItems"],data:function(){return{posData:{},groupsList:null,colorGroups:[],infoBoxFrozen:!1}},modules:{},components:{regionDotsVector:Yt},mounted:function(){this.renderPlot(),window.addEventListener("resize",this.onResize)},beforeDestroy:function(){window.removeEventListener("resize",this.onResize)},computed:{adjPlotMargin:function(){var t=this.plotConfig["plot margin"]?this.plotConfig["plot margin"]:null,e=t?{left:t.left,right:t.right,top:t.top,bottom:t.bottom,bump:t.bump?t.bump:10}:{left:this.plotMargin.leftMargin,right:this.plotMargin.rightMargin,top:this.plotMargin.topMargin,bottom:this.plotMargin.bottomMargin,bump:this.plotMargin.bump};return e},viewingRegion:function(){if(null==this.region)return null;var t={};t["chr"]=parseInt(this.region.split(":")[0],10);var e=this.region.split(":")[1].split("-"),n=this.region.split(":")[0],r=parseInt(e[0],10),a=parseInt(e[1],10),i=a-r;if(this.regionZoom>0){var o=Math.round(i*(this.regionZoom/200)),s=Math.round(o*(this.regionViewArea/100));t["chr"]=n,t["start"]=r+o+s,t["end"]=a-o+s}else 0==this.regionZoom&&(t["chr"]=n,t["start"]=r,t["end"]=a);return t},renderData:function(){var t=this,e={high:null,low:null,data:this.plotData},n=[];return this.plotData.map((function(r){t.plotConfig["color by"]&&!n.includes(r[t.plotConfig["color by"]])&&n.push(r[t.plotConfig["color by"]]);var a=r[t.plotConfig["y axis field"]];e.high=!e.high||e.high<a?a:e.high,e.low=!e.low||e.low>a?a:e.low})),this.colorGroups=n.sort(),e}},watch:{viewingRegion:function(t){this.renderPlot()},plotData:function(t){this.renderPlot()},starItems:function(t){this.renderPlot()}},methods:{downloadImage:function(t,e,n){"svg"==n?(this.$refs[this.sectionId+"_regionDots"].renderPlot(),this.utils.uiUtils.downloadImg(t,e,n,"vector_region_dots_"+this.sectionId)):"png"==n&&this.utils.uiUtils.downloadImg(t,e,n)},renderPlot:function(t){var e=this;this.posData={};var n,r,a=2*this.plotConfig["track height"],i=2*document.querySelector("#region_track_wrapper"+this.sectionId).clientWidth,o=a+this.adjPlotMargin.top+this.adjPlotMargin.bottom;n=document.getElementById("track_"+this.sectionId),n.setAttribute("width",i),n.setAttribute("height",o),n.setAttribute("style","background-color: #ffffff;width: "+i/2+"px;height:"+o/2+"px;"),r=n.getContext("2d"),r.clearRect(0,0,i,o);var s=o-(this.adjPlotMargin.top+this.adjPlotMargin.bottom),l=i-(this.adjPlotMargin.left+this.adjPlotMargin.right),c=this.viewingRegion,u=l/(c.end-c.start),d=s/(this.renderData.high-this.renderData.low);this.renderAxis(r,l,s,Number(c.end),Number(c.start),this.renderData.high,this.renderData.low,this.adjPlotMargin);var h=this.plotConfig["x axis field"],p=this.plotConfig["y axis field"],f=this.adjPlotMargin.left,_=this.adjPlotMargin.top+s;if(this.colorGroups.map((function(t,n){var a=e.plotData.filter((function(n){return n[e.plotConfig["color by"]]===t})),i=n%16,o=i||0===i?e.colors.moderate[i]:"#00000066";a.map((function(t,n){var a=t[h],i=t[p];if(a>=c.start&&a<=c.end){var s=f+(a-c.start)*u,l=_-(i-e.renderData.low)*d;r.fillStyle=o,r.lineWidth=0,r.beginPath();var g=9;r.arc(s,l,g,0,2*Math.PI),r.fill(),e.posData[Math.round(l/2)]||(e.posData[Math.round(l/2)]=[]),e.posData[Math.round(l/2)].push({x:Math.round(s/2),data:t})}}))})),this.starItems){var g=this.adjPlotMargin.top-this.adjPlotMargin.bump,m=this.adjPlotMargin.top+s+3*this.adjPlotMargin.bump;this.starItems.map((function(t){var n=f+(t.columns[e.plotConfig["x axis field"]]-c.start)*u;e.utils.plotUtils.renderDashedLine(r,n,g,n,m,3,"#FFAA0055",[6,2])}))}},renderAxis:function(t,e,n,r,a,i,o,s){t.beginPath(),t.lineWidth=1,t.strokeStyle="#000000",t.setLineDash([]),t.moveTo(s.left-s.bump,s.top),t.lineTo(s.left-s.bump,s.top+n+s.bump),t.stroke();for(var l=(i-o)/2,c=n/2,u=0;u<3;u++){var d=s.top+u*c,h=Math.floor(d);t.moveTo(s.left-s.bump,h),t.lineTo(s.left-2*s.bump,h),t.stroke(),t.textAlign="end",t.font="24px Arial",t.fillStyle="#000000";var p=i-o,f=p<=1?2:p<=50?1:0,_=this.utils.Formatters.decimalFormatter(i-u*l,f);_=_>=1e5?Math.round(.001*_)+"k":_,t.fillText(_,s.left-3*s.bump,h)}var g=Math.round(s.left+e+s.bump);t.moveTo(g,s.top),t.lineTo(g,s.top+n+s.bump),t.stroke(),t.moveTo(s.left-s.bump,s.top+n+s.bump),t.lineTo(g,s.top+n+s.bump),t.stroke();for(var m=Math.ceil((r-a)/5),v=e/5,y=0;y<6;y++){var b=s.left+y*v,x=Math.floor(b);t.moveTo(x,s.top+n+s.bump),t.lineTo(x,s.top+n+2*s.bump),t.stroke(),t.textAlign="center",t.font="24px Arial",t.fillStyle="#000000";var w=r-a,C=w<=1?2:w<=50?1:0,P=this.utils.Formatters.decimalFormatter(a+y*m,C);P=P>=1e5?Math.round(.001*P)+"k":P,t.fillText(P,x,s.top+n+36+s.bump)}},checkPosition:function(t,e){var n=this;if(0==this.infoBoxFrozen){var r=t.target.getBoundingClientRect(),a=Math.floor(t.clientX-r.left),i=Math.floor(t.clientY-r.top),o=document.getElementById("block_data_"+this.sectionId),s=document.getElementById("block_data_content_"+this.sectionId),l=document.getElementById("track_"+this.sectionId);"click"==e&&o.setAttribute("style","");var c=Object.keys(this.posData),u=[];

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1t&&(Object.values(this.buffers.points).forEach((function(e){e&&t.deleteBuffer(e)})),Object.values(this.buffers.axes).forEach((function(e){e&&t.deleteBuffer(e)})),Object.values(this.buffers.hover).forEach((function(e){e&&t.deleteBuffer(e)})),this.buffers={points:{},axes:{},hover:{}})},cleanUp:function(){this.cleanUpBuffers(),this.gl&&this.program&&this.gl.deleteProgram(this.program),this.rafId&&(cancelAnimationFrame(this.rafId),this.rafId=null),this.program=null,this.gl=null,this.locations=null,O.hide(),this.sharedGroupAttached&&(ct.release(this.group),this.sharedGroupAttached=!1)},setupAxisIndicatorCanvas:function(t){var e=this.$refs.axisIndicatorCanvas;e&&(e.width=_t*t,e.height=_t*t,e.style.width="".concat(_t,"px"),e.style.height="".concat(_t,"px"))},calculatePointBounds:function(){var t={minX:1/0,maxX:-1/0,minY:1/0,maxY:-1/0,minZ:1/0,maxZ:-1/0};this.points.forEach((function(e){var n,r=null!==(n=e.Z)&&void 0!==n?n:0;e.X<t.minX&&(t.minX=e.X),e.X>t.maxX&&(t.maxX=e.X),e.Y<t.minY&&(t.minY=e.Y),e.Y>t.maxY&&(t.maxY=e.Y),r<t.minZ&&(t.minZ=r),r>t.maxZ&&(t.maxZ=r)}));var e=[Math.max(t.maxX-t.minX,1),Math.max(t.maxY-t.minY,1),Math.max(t.maxZ-t.minZ,1)],n=[(t.minX+t.maxX)/2,(t.minY+t.maxY)/2,(t.minZ+t.maxZ)/2];this.pointBounds=Object(s["a"])(Object(s["a"])({},t),{},{size:e,center:n,radius:Math.max.apply(Math,e)/2||1})},calculateClusterCenters:function(){var t=this;this.clusterCenters=[];var e=this.cellTypeField||Object.keys(this.labels.metadata_labels)[0],n=this.labels.metadata[e],r=this.labels.metadata_labels[e],a={};this.points.forEach((function(e,i){var o,s=n[i],l=r[s]||"Unlabeled";a[l]||(a[l]={xSum:0,ySum:0,zSum:0,count:0}),a[l].xSum+=e.X,a[l].ySum+=e.Y,a[l].zSum+=t.is3dMode&&null!==(o=e.Z)&&void 0!==o?o:0,a[l].count++})),Object.entries(a).forEach((function(e){var n=Object(o["a"])(e,2),r=n[0],a=n[1];t.clusterCenters.push({label:r,position:[a.xSum/a.count,a.ySum/a.count,a.zSum/a.count]})}))},resetCameraFromBounds:function(){this.projection.aspect=this.$refs.umapCanvas.width/Math.max(this.$refs.umapCanvas.height,1);var t,e=1-2*ht;if(this.is3dMode){var n=-Math.PI/4,r=Math.PI/7,a=Mt([Math.cos(r)*Math.sin(n),Math.sin(r),Math.cos(r)*Math.cos(n)]),i=Mt(wt(a,-1)),s=Mt(Pt(i,[0,1,0])),l=Mt(Pt(s,i)),c=Math.tan(this.projection.fov/2)*e,d=c*this.projection.aspect,h=Object(o["a"])(this.pointBounds.size,3),p=h[0],f=h[1],_=h[2],g=[p/2,f/2,_/2];t=this.projection.near;for(var m=0,v=[-g[0],g[0]];m<v.length;m++)for(var y=v[m],b=0,x=[-g[1],g[1]];b<x.length;b++)for(var w=x[b],C=0,P=[-g[2],g[2]];C<P.length;C++){var k=P[C],M=[y,w,k],E=Math.abs(Ct(M,s)),D=Math.abs(Ct(M,l)),O=Ct(M,i);t=Math.max(t,E/Math.max(d,dt)-O,D/Math.max(c,dt)-O)}t*=pt}else{var L=Math.max(this.pointBounds.size[0]/2,dt),j=Math.max(this.pointBounds.size[1]/2,dt);this.orthoBaseHalfHeight=Math.max(j,L/Math.max(this.projection.aspect,dt))/Math.max(e,dt),t=1}var S={target:Object(u["a"])(this.pointBounds.center),distance:t,yaw:this.is3dMode?-Math.PI/4:0,pitch:this.is3dMode?Math.PI/7:0};this.camera={target:Object(u["a"])(S.target),distance:S.distance,yaw:S.yaw,pitch:S.pitch},this.resetCamera={target:Object(u["a"])(S.target),distance:S.distance,yaw:S.yaw,pitch:S.pitch},this.updateCameraState()},initializeWebGL:function(){var t=this.$refs.umapCanvas,e=t.getContext("webgl",{preserveDrawingBuffer:!0});if(e){this.gl=e;var n="\n                attribute vec3 a_position;\n                attribute vec4 a_color;\n                attribute float a_isHighlight;\n\n                uniform mat4 u_matrix;\n                uniform float u_pointSize;\n                uniform float u_renderPoints;\n                uniform float u_hoverScale;\n                uniform float u_minPointScale;\n                uniform float u_maxPointScale;\n                uniform float u_highlightMode;\n\n                varying vec4 v_color;\n                varying float v_renderPoints;\n\n                void main() {\n                    if (u_highlightMode < 1.5 && a_isHighlight < 0.5) {\n                        gl_Position = vec4(-2.0, -2.0, 0.0, 1.0);\n                        gl_PointSize = 0.0;\n                        v_color = vec4(0.0);\n                        v_renderPoints = u_renderPoints;\n                        return;\n                    }\n\n                    if (u_highlightMode > 1.5 && a_isHighlight > 0.5) {\n                        gl_Position = vec4(-2.0, -2.0, 0.0, 1.0);\n                        gl_PointSize = 0.0;\n                        v_color = vec4(0.0);\n                        v_renderPoints = u_renderPoints;\n                        return;\n                    }\n\n                    gl_Position = u_matrix * vec4(a_position, 1.0

1);\n                    float pointScale = mix(u_minPointScale, u_maxPointScale, a_isHighlight);\n                    gl_PointSize = u_pointSize * pointScale * u_hoverScale;\n                    v_color = a_color;\n                    v_renderPoints = u_renderPoints;\n                }\n            ",r="\n                precision mediump float;\n                varying vec4 v_color;\n                varying float v_renderPoints;\n\n                void main() {\n                    if (v_renderPoints > 0.5) {\n                        vec2 centered = gl_PointCoord - vec2(0.5);\n                        if (dot(centered, centered) > 0.25) {\n                            discard;\n                        }\n                    }\n\n                    gl_FragColor = v_color;\n                }\n            ",a=this.createShader(e,e.VERTEX_SHADER,n),i=this.createShader(e,e.FRAGMENT_SHADER,r);this.program=this.createProgram(e,a,i),e.useProgram(this.program),this.locations={position:e.getAttribLocation(this.program,"a_position"),color:e.getAttribLocation(this.program,"a_color"),highlight:e.getAttribLocation(this.program,"a_isHighlight"),matrix:e.getUniformLocation(this.program,"u_matrix"),pointSize:e.getUniformLocation(this.program,"u_pointSize"),renderPoints:e.getUniformLocation(this.program,"u_renderPoints"),hoverScale:e.getUniformLocation(this.program,"u_hoverScale"),minPointScale:e.getUniformLocation(this.program,"u_minPointScale"),maxPointScale:e.getUniformLocation(this.program,"u_maxPointScale"),highlightMode:e.getUniformLocation(this.program,"u_highlightMode")},e.enable(e.BLEND),e.blendFunc(e.SRC_ALPHA,e.ONE_MINUS_SRC_ALPHA),e.enable(e.DEPTH_TEST)}},getActiveLabelField:function(){return this.colorByField||this.cellTypeField||Object.keys(this.labels.metadata_labels)[0]},updateExpressionScale:function(){if(!this.expression||0===this.expression.length)return this.expressionScale=null,void(this.expressionExtent={min:null,max:null});for(var t=1/0,e=-1/0,n=0;n<this.expression.length;n++){var r=this.expression[n];null==r||Number.isNaN(r)||(r<t&&(t=r),r>e&&(e=r))}if(t===1/0||e===-1/0)return this.expressionScale=null,void(this.expressionExtent={min:null,max:null});this.expressionExtent={min:t,max:e},this.expressionScale=h["scaleSequential"](this.currColorOption).domain([0,e])},buildPointOrder:function(){var t=this,e=this.points.length,n=Array.from({length:e},(function(t,e){return e}));return!this.is3dMode&&this.expression&&n.sort((function(e,n){var r,a,i=null!==(r=t.expression[e])&&void 0!==r?r:-1/0,o=null!==(a=t.expression[n])&&void 0!==a?a:-1/0;return i-o})),n},buildPositionBuffer:function(t){for(var e=t.length,n=ct.getPositions(this.group),r=new Float32Array(3*e),a=0;a<e;a++){var i=t[a];r[3*a]=n[3*i],r[3*a+1]=n[3*i+1],r[3*a+2]=this.is3dMode?n[3*i+2]:0}return r},buildColorBuffer:function(t){for(var e=this.getActiveLabelField(),n=this.labels.metadata[e],r=this.labels.metadata_labels[e],a=new Uint8Array(4*t.length),i=this.colors[e]||{},o=0;o<t.length;o++){var s=t[o],l=void 0;if(this.expressionScale&&null!=this.expression[s])l=St(this.expressionScale(this.expression[s]));else{var c=n[s],u=r[c];l=St(i[u]||"#000000")}l[3]=255,a.set(l,4*o)}return a},buildAxisBuffers:function(){var t=Object(o["a"])(this.pointBounds.size,3),e=t[0],n=t[1],r=t[2],a=.65*Math.max(e,n,r)||1,i=Object(o["a"])(this.pointBounds.center,3),s=i[0],l=i[1],c=i[2],d=new Float32Array([s-a,l,c,s+a,l,c,s,l-a,c,s,l+a,c,s,l,c-a,s,l,c+a]),h=St("#d64545"),p=St("#2e9b46"),f=St("#2f6fe4"),_=new Uint8Array([].concat(Object(u["a"])(h),Object(u["a"])(h),Object(u["a"])(p),Object(u["a"])(p),Object(u["a"])(f),Object(u["a"])(f))),g=new Uint8Array([255,255,255,255,255,255]);return{positions:d,colors:_,highlight:g,vertexCount:6}},makeBuffer:function(t){var e=arguments.length>1&&void 0!==arguments[1]?arguments[1]:null,n=this.gl,r=e||n.createBuffer();return n.bindBuffer(n.ARRAY_BUFFER,r),n.bufferData(n.ARRAY_BUFFER,t,n.STATIC_DRAW),r},setupBuffers:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},e=this.gl;if(e){var n=t.rebuildPositions,r=void 0===n||n,a=t.rebuildColors,i=void 0===a||a,o=t.rebuildOrder,s=void 0===o||o,l=t.rebuildHighlight,c=void 0===l||l,u=t.rebuildAxes,d=void 0===u||u;if((s||this.pointDrawOrder.length!==this.points.length)&&(this.pointDrawOrder=this.buildPointOrder()),this.vertexCount=this.points.length,r){var h=this.buildPositionBuffer(this.pointDrawOrder);this.buffers.points.position=this.makeBuffer(h,this.buffers.points.position)}if(i){var p=this.buildColorBuffer(this.pointDrawOrder);this.buffers.points.color=this.makeBuffer(p,this.buffers.points.color)}if(c&&this.updateHighlightBuffer(this.pointDrawOrder),d){var f=this.buildAxisBuffers();this.axisVertexCount=f.vertexCount,this.buffers.axes.position=this.makeBuffer(f.positions,this.buffers.axes.position),this.buffers.axes.color=this.makeBuffer(f.colors,this.buffers.axes.color),this.buffers.axes.highlight=this.makeBuffer(f.highlight,this.buffers.axes.highlight)}this.updateHoverBuffer()}},updateHoverBuffer:function(){var t,e=this.gl;if(e)if(-1!==this.hoveredPointIndex){var n=this.points[this.hoveredPointIndex];if(n){var r=new Float32Array([n.X,n.Y,this.is3dMode&&null!==(t=n.Z)&&void 0!==t?t:0]),a=new Uint8Array([0,0,0,255]),i=new Uint8Array([255]);this.buffers.hover.position=this.makeBuffer(r,this.buffers.hover.position),this.buffers.hover.color=this.makeBuffer(a,this.buffers.hover.color),this.buffers.hover.highlight=this.makeBuffer(i,this.buffers.hover.highlight),this.hoverVertexCount=1}else this.hoverVertexCount=0}else this.hoverVertexCount=0},updateHighlightBuffer:function(){var t=arguments.length>0&&void 0!==arguments[0]?arguments[0]:null,e=this.gl;if(e){for(var n=t||this.pointDrawOrder||Array.from({length:this.vertexCount},(function(t,e){return e})),r=this.getActiveLabelField(),a=this.labels.metadata[r],i=this.labels.metadata_labels[r],o=!!this.highlightLabel||this.highlightLabels.length>0,s=new Uint8Array(n.length),l=0;l<n.length;l++){var c=n[l];if(o){var u=a[c],d=i[u];s[l]=d===this.highlightLabel||this.highlightLabels.includes(d)?255:0}else s[l]=255}this.buffers.points.highlight=this.makeBuffer(s,this.buffers.points.highlight)}},getEyePosition:function(){var t=this.camera,e=t.target,n=t.distance,r=t.yaw,a=t.pitch;return[e[0]+n*Math.cos(a)*Math.sin(r),e[1]+n*Math.sin(a),e[2]+n*Math.cos(a)*Math.cos(r)]},updateCameraState:function(){if(this.is3dMode){var t=this.getEyePosition(),e=this.camera.target,n=Mt(xt(e,t)),r=Mt(Pt(n,[0,1,0])),a=Mt(Pt(r,n));return this.cameraVectors={eye:t,forward:n,right:r,up:a},this.orthoBounds=null,this.viewMatrix=Ot(t,e,a),void(this.renderMatrix=Lt(Et(this.projection.fov,this.projection.aspect,this.projection.near,this.projection.far),this.viewMatrix))}var i=this.camera.distance/this.resetCamera.distance,s=Math.max(this.orthoBaseHalfHeight*i,.1),l=s*this.projection.aspect,c=Object(o["a"])(this.camera.target,2),u=c[0],d=c[1];this.orthoBounds={left:u-l,right:u+l,top:d+s,bottom:d-s},this.cameraVectors={eye:[u,d,this.camera.distance],forward:[0,0,-1],right:[1,0,0],up:[0,1,0]},this.viewMatrix=vt,this.renderMatrix=Dt(u-l,u+l,d-s,d+s,-Math.max(4*this.pointBounds.radius,10),Math.max(4*this.pointBounds.radius,10))},projectWorldPoint:function(t){if(!this.renderMatrix)return null;var e=jt(this.renderMatrix,t),n=e[3];

1if(Math.abs(n)<dt)return null;var r=e[0]/n,a=e[1]/n,i=e[2]/n,o=this.$refs.umapCanvas;return{x:(.5*r+.5)*o.width,y:(1-(.5*a+.5))*o.height,depth:i,visible:r>=-1&&r<=1&&a>=-1&&a<=1&&i>=-1&&i<=1}},updateProjectedGeometry:function(){var t=this;this.is3dMode?this.projectedPoints=this.points.map((function(e){var n;return t.projectWorldPoint([e.X,e.Y,null!==(n=e.Z)&&void 0!==n?n:0])})):this.projectedPoints=[],this.projectedLabels=this.clusterCenters.map((function(e){var n=t.projectWorldPoint(e.position);return n&&n.visible?Object(s["a"])(Object(s["a"])({},e),{},{projection:n}):null})).filter(Boolean)},requestRender:function(){var t=this,e=arguments.length>0&&void 0!==arguments[0]&&arguments[0];e&&(this.renderProjectionDirty=!0),this.renderQueued||(this.renderQueued=!0,this.rafId=requestAnimationFrame((function(){t.renderQueued=!1,t.rafId=null,t.renderUMAP(),t.syncPending&&(t.syncPending=!1,t.updateViewTransform())})))},scheduleSync:function(){this.syncPending=!0},renderUMAP:function(){this.gl&&this.program&&(this.projection.aspect=this.$refs.umapCanvas.width/Math.max(this.$refs.umapCanvas.height,1),this.updateCameraState(),!this.renderProjectionDirty&&this.interactionMode&&this.is3dMode||(this.updateProjectedGeometry(),this.renderProjectionDirty=!1),this.renderPoints(),this.drawLabels(),this.drawAxisIndicator())},drawAxisIndicator:function(){var t=this,e=this.$refs.axisIndicatorCanvas;if(e){var n=e.getContext("2d"),r=window.devicePixelRatio||1,a=e.width/2,i=.24*e.width,o=.09*e.width;if(n.clearRect(0,0,e.width,e.height),this.is3dMode){var l=[{label:"X",vector:[1,0,0],color:"#d64545"},{label:"Y",vector:[0,1,0],color:"#2e9b46"},{label:"Z",vector:[0,0,1],color:"#2f6fe4"}].map((function(e){var n=Ct(e.vector,t.cameraVectors.right),r=Ct(e.vector,t.cameraVectors.up),a=Ct(e.vector,t.cameraVectors.forward);return Object(s["a"])(Object(s["a"])({},e),{},{screenX:n,screenY:r,depth:a})})).sort((function(t,e){return t.depth-e.depth}));n.font="".concat(11*r,"px Arial"),n.textAlign="center",n.textBaseline="middle",l.forEach((function(t){var e=a+t.screenX*i,s=a-t.screenY*i,l=a+t.screenX*(i+o),c=a-t.screenY*(i+o);n.strokeStyle=t.color,n.lineWidth=2.5*r,n.beginPath(),n.moveTo(a,a),n.lineTo(e,s),n.stroke(),n.fillStyle=t.color,n.beginPath(),n.arc(e,s,3*r,0,2*Math.PI),n.fill(),n.fillText(t.label,l,c)}))}}},bindAttributes:function(t){var e=this.gl;e.bindBuffer(e.ARRAY_BUFFER,t.position),e.enableVertexAttribArray(this.locations.position),e.vertexAttribPointer(this.locations.position,3,e.FLOAT,!1,0,0),e.bindBuffer(e.ARRAY_BUFFER,t.color),e.enableVertexAttribArray(this.locations.color),e.vertexAttribPointer(this.locations.color,4,e.UNSIGNED_BYTE,!0,0,0),e.bindBuffer(e.ARRAY_BUFFER,t.highlight),e.enableVertexAttribArray(this.locations.highlight),e.vertexAttribPointer(this.locations.highlight,1,e.UNSIGNED_BYTE,!0,0,0)},renderPoints:function(){var t=this.gl;t.viewport(0,0,t.canvas.width,t.canvas.height),t.clearColor(1,1,1,1),t.clear(t.COLOR_BUFFER_BIT|t.DEPTH_BUFFER_BIT),t.useProgram(this.program),t.uniformMatrix4fv(this.locations.matrix,!1,this.renderMatrix);var e=this.is3dMode?yt(Math.max(1.25,4.5-Math.log10(Math.max(this.camera.distance/this.pointBounds.radius,1))),1.25,5):yt(2.2/(this.camera.distance/this.resetCamera.distance),1.15,3),n=!!this.highlightLabel||this.highlightLabels.length>0;this.is3dMode?t.enable(t.DEPTH_TEST):t.disable(t.DEPTH_TEST),this.is3dMode&&(this.bindAttributes(this.buffers.axes),t.uniform1f(this.locations.renderPoints,0),t.uniform1f(this.locations.pointSize,1),t.uniform1f(this.locations.hoverScale,1),t.uniform1f(this.locations.minPointScale,1),t.uniform1f(this.locations.maxPointScale,1),t.uniform1f(this.locations.highlightMode,0),t.drawArrays(t.LINES,0,this.axisVertexCount)),this.bindAttributes(this.buffers.points),t.uniform1f(this.locations.renderPoints,1),t.uniform1f(this.locations.pointSize,e*(window.devicePixelRatio||1)),t.uniform1f(this.locations.hoverScale,1),n?(t.uniform1f(this.locations.minPointScale,this.is3dMode?.3:.2),t.uniform1f(this.locations.maxPointScale,this.is3dMode?1.6:2),t.uniform1f(this.locations.highlightMode,2),t.drawArrays(t.POINTS,0,this.vertexCount),t.uniform1f(this.locations.highlightMode,1),t.drawArrays(t.POINTS,0,this.vertexCount)):(t.uniform1f(this.locations.minPointScale,1),t.uniform1f(this.locations.maxPointScale,1),t.uniform1f(this.locations.highlightMode,0),t.drawArrays(t.POINTS,0,this.vertexCount)),this.hoverVertexCount>0&&(this.bindAttributes(this.buffers.hover),t.uniform1f(this.locations.renderPoints,1),t.uniform1f(this.locations.pointSize,1.75*e*(window.devicePixelRatio||1)),t.uniform1f(this.locations.hoverScale,1),t.uniform1f(this.locations.minPointScale,1),t.uniform1f(this.locations.maxPointScale,1),t.uniform1f(this.locations.highlightMode,0),t.drawArrays(t.POINTS,0,this.hoverVertexCount))},drawLabels:function(){var t=this.$refs.umapLabelCanvas,e=t.getContext("2d");e.clearRect(0,0,t.width,t.height),this.showLabels&&(this.is3dMode&&this.interactionMode||(e.font="".concat(14*(window.devicePixelRatio||1),"px Arial"),e.fillStyle="black",e.textAlign="center",e.textBaseline="middle",e.strokeStyle="white",e.lineWidth=5,this.projectedLabels.forEac

1h((function(t){e.strokeText(t.label,t.projection.x,t.projection.y),e.fillText(t.label,t.projection.x,t.projection.y)}))))},panCamera:function(t,e){var n,r,a=this.$refs.umapCanvas;if(this.is3dMode){var i=2*this.camera.distance*Math.tan(this.projection.fov/2)/Math.max(a.height,1);n=i*ft,r=n}else n=this.camera.distance/this.resetCamera.distance*(.0045*this.pointBounds.radius),r=n*(a.width/Math.max(a.height,1));var o=bt(wt(this.cameraVectors.right,-t*r),wt(this.cameraVectors.up,e*n));this.camera.target=bt(this.camera.target,o)},rotateCamera:function(t,e){this.is3dMode&&(this.camera.yaw-=.01*t,this.camera.pitch=yt(this.camera.pitch+.01*e,-Math.PI/2+.05,Math.PI/2-.05))},onWheel:function(t){var e=t.deltaY<0?.9:1.1;this.is3dMode?this.camera.distance=yt(this.camera.distance*e,.2*this.pointBounds.radius,30*this.pointBounds.radius):this.camera.distance=yt(this.camera.distance*e,this.resetCamera.distance*gt,this.resetCamera.distance*mt),this.scheduleSync(),this.requestRender(!0)},onMouseDown:function(t){this.interactionMode=!this.is3dMode||2===t.button||t.shiftKey?"pan":"rotate",this.lastMouse.x=t.clientX,this.lastMouse.y=t.clientY},onMouseMove:function(t){var e=t.clientX-this.lastMouse.x,n=t.clientY-this.lastMouse.y;if(this.interactionMode)return"rotate"===this.interactionMode?this.rotateCamera(e,n):this.panCamera(e,n),this.lastMouse.x=t.clientX,this.lastMouse.y=t.clientY,O.hide(),this.scheduleSync(),void this.requestRender(!1);this.lastMouse.x=t.clientX,this.lastMouse.y=t.clientY,this.isHovering&&this.showTooltips&&this.handleHover(t)},handleHover:function(t){var e=this.$refs.umapCanvas.getBoundingClientRect(),n=this.$refs.umapCanvas.width/Math.max(e.width,1),r=(t.clientX-e.left)*n,a=(t.clientY-e.top)*n;if(!this.is3dMode){var i=this.find2DHoverIndex(r,a);return this.updateHoveredPoint(i),-1===i?void O.hide():void this.showHoverTooltip(i)}for(var o=-1,s=1/0,l=12*(window.devicePixelRatio||1),c=0;c<this.projectedPoints.length;c++){var u=this.projectedPoints[c];if(u&&u.visible){var d=u.x-r,h=u.y-a,p=Math.hypot(d,h);p<l&&p<s&&(s=p,o=c)}}this.updateHoveredPoint(o),-1!==o?this.showHoverTooltip(o):O.hide()},find2DHoverIndex:function(t,e){var n;if(!this.orthoBounds)return-1;var r=this.$refs.umapCanvas,a=this.orthoBounds.left+t/r.width*(this.orthoBounds.right-this.orthoBounds.left),i=this.orthoBounds.top-e/r.height*(this.orthoBounds.top-this.orthoBounds.bottom),o=Math.max((this.orthoBounds.right-this.orthoBounds.left)/r.width*8,(this.orthoBounds.top-this.orthoBounds.bottom)/r.height*8),s=null===(n=ct.getQuadtree(this.group))||void 0===n?void 0:n.find(a,i,o);if(!s)return-1;var l=ct.getPointIndex(this.group,s);return null==l?-1:l},updateHoveredPoint:function(t){this.hoveredPointIndex!==t&&(this.hoveredPointIndex=t,this.updateHoverBuffer(),this.requestRender(!1))},showHoverTooltip:function(t){var e=this,n='<div style="display:grid; grid-template-columns: max-content 1fr; grid-column-gap: 5px; font-size: 12px;">';n+='<div style="font-weight:bold">Cell ID</div><div>'.concat((this.labels.NAME||this.labels.ID)[t],"</div>"),this.expression&&(n+='<div style="font-weight:bold">Expression</div><div>'.concat(this.expression[t],"</div>")),Object.keys(this.labels.metadata_labels).forEach((function(r){if(e.isHoverField(r)){var a=e.labels.metadata_labels[r][e.labels.metadata[r][t]];a&&""!==a&&(n+='<div style="font-weight:bold;">'.concat(r,"</div><div>").concat(a,"</div>"))}})),n+="</div>",O.show(n)},isHoverField:function(t){return!this.hoverFields||0===this.hoverFields.length||this.hoverFields.includes(t)},onMouseOver:function(){this.isHovering=!0},onMouseOut:function(){this.isHovering=!1,this.updateHoveredPoint(-1),O.hide()},onMouseUp:function(){this.interactionMode=null,this.requestRender(!0)},onMouseLeave:function(){this.interactionMode=null,this.isHovering=!1,this.updateHoveredPoint(-1),O.hide(),this.requestRender(!0)},onClick:function(){},resetPanZoom:function(){this.camera={target:Object(u["a"])(this.resetCamera.target),distance:this.resetCamera.distance,yaw:this.resetCamera.yaw,pitch:this.resetCamera.pitch},this.scheduleSync(),this.requestRender(!0)},updateViewTransform:function(){_["a"].$emit("view-transform-change",{id:this.group,viewMode:this.is3dMode?"3d":"2d",camera:{target:Object(u["a"])(this.camera.target),distance:this.camera.distance,yaw:this.camera.yaw,pitch:this.camera.pitch}})},handleUpdateViewTransform:function(t){t.id===this.group&&t.viewMode===(this.is3dMode?"3d":"2d")&&t.camera&&(this.camera={target:Object(u["a"])(t.camera.target),distance:t.camera.distance,yaw:t.camera.yaw,pitch:t.camera.pitch},this.requestRender(!0))},createShader:function(t,e,n){var r=t.createShader(e);return t.shaderSource(r,n),t.compileShader(r),t.getShaderParameter(r,t.COMPILE_STATUS)?r:(t.deleteShader(r),null)},createProgram:function(t,e,n){var r=t.createProgram();return t.attachShader(r,e),t.attachShader(r,n),t.linkProgram(r),t.getProgramParameter(r,t.LINK_STATUS)?r:(t.deleteProgram(r),null)},download:function(){var t=this.$refs.umapCanvas,e=this.$refs.umapLabelCanvas,n=2,r=document.createElement("canvas");r.width=t.width*n,r.height=t.height*n;var a=r.getContext("2d");a.imageSmoothingEnabled=!0,a.imageSmoothingQuality="high",a.drawImage(t,0,0,r.width,r.height),a.drawImage(e,0,0,r.width,r.height);var i=document.createElement("a");i.download="umap.png",i.href=r.toDataURL("image/png"),i.click()}}}),It=At,Tt=(n("a12e"),Object(C["a"])(It,rt,at,!1,null,"51da75aa",null)),Bt=Tt.exports,Rt=function(){var t=this,e=t.$createElement,n=t._self._c||e;return n("div",{ref:"chartWrapper",staticStyle:{width:"100%",position:"relative","overflow-x":"hidden"}},[n("div",{ref:"chart"})])},Ft=[],Gt=p["default"].component("research-stacked-bar-plot",{props:{data:{type:null,required:!0},primaryKey:{type:String,required:!0},subsetKey:{type:String,required:!1},facetKey:{type:String,required:!1},highlightKey:{type:String,required:!1},normalize:{type:Boolean,default:!1},stack:{type:Boolean,default:!1},height:{type:Number,default:300},xAxisLabel:{type:String,required:!1},yAxisLabel:{type:String,required:!1},range:{type:Array,required:!1},verticalCategoryLayout:{type:Boolean,default:!1}},data:function(){return{isNormalized:!1,isStacked:!1,eventElements:[],resizeTimeout:null,resizeObserver:null}},watch:{data:function(){this.drawChart()},stack:function(){this.isStacked=this.stack,this.drawChart()},normalize:function(){this.isNormalized=this.normalize,this.drawChart()},verticalCategoryLayout:function(){this.drawChart()},highlightKey:function(t,e){this.doHighlight(t)}},mounted:function(){this.data?this.drawChart():m("no data"),window.addEventListener("resize",this.handleResize),this.initResizeObserver()},beforeDestroy:function(){window.removeEventListener("resize",this.handleResize),this.teardownResizeObserver(),this.eventElements.length>0&&this.removeAllListeners(this.eventElements)},methods:{initResizeObserver:function(){var t,e=this;if("undefined"!==typeof ResizeObserver){var n=(null===(t=this.$refs.chartWrapper)||void 0===t?void 0:t.parentElement)||this.$refs.chartWrapper;n&&(this.resizeObserver=new ResizeObserver((function(){e.handleResize()})),this.resizeObserver.observe(n))}},teardownResizeObserver:function(){this.resizeObserver&&(this.resizeObserver.disconnect(),this.resizeObserver=null)},handleResize:function(){var t=this;clearTimeout(this.resizeTimeout),this.resizeTimeout=setTimeout((function(){t.drawChart()}),100)},drawChart:function(){var t=this;if(h["select"](this.$refs.chart).style("position","relative"),m("---StackedBar Plot"),m("   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y=g-_.left-_.right-f.xAxis,b=v-_.top-_.bottom-f.yAxis;this.$refs.chartWrapper.style.height=v+"px";var x=[],w={};this.data.forEach((function(t){w[t[e]]||(w[t[e]]=0),w[t[e]]+=t.count})),x=Object.entries(w).map((function(t){var n=Object(o["a"])(t,2),r=n[0],a=n[1];return Object(d["a"])(Object(d["a"])({},e,r),"count",a)}));var C=h["sum"](x,(function(t){return t.count})),P=0,k=this.range?this.range[1]:h["max"](this.data,(function(t){return t.count})),M=0,E=h["max"](x,(function(t){return t.count})),D=function(t){return r?t[e]+" - "+t[n]:t[e]};if(this.verticalCategoryLayout)this.drawVerticalCategoryChart({primaryKey:e,subsetKey:n,hasSubsetKey:r,primaryKeys:a,primaryCounts:x,primarySum:C,min:P,max:k,minPrimary:M,maxPrimary:E,entryKey:D});else{var O=h["select"](this.$refs.chart).append("svg").attr("id","sc_stacked_bar_plot").attr("width",g).attr("height",v);if(this.xAxisLabel){var L=O.append("g").append("text").attr("style","font-size:12px; opacity:0.5; font-family: 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e.datasetId===t.datasetId})),e.next=42;break;case 41:return e.abrupt("return");case 42:return m("datasetMetadata",t.metadata),t.totalDatasets=t.singleCellMetadata.length,t.totalCells=t.metadata.totalCells,t.embeddingType=null!==(a=t.metadata.embedding_method)&&void 0!==a?a:t.embeddingType,b=t.renderConfig.format,x=null===b||void 0===b?void 0:b[t.datasetId],w=null===b||void 0===b?void 0:b.default,null!==x&&void 0!==x&&x.stratifyPlotType&&t.stratifyPlotTypeOptions.includes(x.stratifyPlotType)&&(t.stratifyPlotType=x.stratifyPlotType),null!==x&&void 0!==x&&x.expressionColorScale&&t.expressionColorScaleOptions.includes(x.expressionColorScale)&&(t.expressionColorScale=x.expressionColorScale),null!==x&&void 0!==x&&x.dotPlotColorScaleMode&&(t.dotPlotColorScaleMode=x.dotPlotColorScaleMode),x?(t.displayFields=x.displayMap||null,t.displayGroups=x.groups||null):w&&(t.displayFields=w.displayMap||null,t.displayGroups=w.groups||null),m("display 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1,Object.keys(t.fields.metadata_labels).forEach((function(e){var n,r=null===(n=t.displayFields)||void 0===n||null===(n=n[e])||void 0===n?void 0:n.customSortOrder,a=t.fields.metadata_labels[e];r&&C(r,a)?t.fields.metadata_labels_sorted[e]=Object(u["a"])(r):t.fields.metadata_labels_sorted[e]=Object(u["a"])(a).sort((function(t,e){return t.localeCompare(e,void 0,{numeric:!0})}))})),t.totalCells||(t.totalCells=(null===(k=t.fields.NAME)||void 0===k?void 0:k.length)|(null===(M=t.fields.ID)||void 0===M?void 0:M.length)),m("fields",t.fields)):m("there was an error getting fields"),3===t.layout){e.next=68;break}return t.preloadItem="coordinates",E=t.selectedBI+t.BIendpoints.coordinates,e.next=66,F(E,t.datasetId);case 66:t.coordinates=e.sent,t.coordinates?m("coordinates",t.coordinates):m("there was an error getting coordinates");case 68:return t.preloadItem="markers",t.markerFile=t.BImarkersDefaultFile,(null===(i=t.metadata)||void 0===i||null===(i=i.marker_gene_files)||void 0===i?void 0:i.length)>1&&(t.markerFileOptions=t.metadata.marker_gene_files,t.markerFileOptions.forEach((function(t){var e=t.marker_gene_level.toLowerCase(),n=e.includes("cell")&&e.includes("type")&&!e.includes("sub");t.markerKey=n?"cell_type":t.marker_gene_level,t.markerKeyLabel=n?"Cell Type":t.marker_gene_level})),t.markerFile=t.markerFileOptions[0]),e.next=73,t.initMarkers(t.markerFile);case 73:return t.preloadItem="",t.dataLoaded=!0,e.next=77,p["default"].nextTick();case 77:return t.traitFields=t.filterDisplayFields(),t.colorByFields=t.filterDisplayFields(),m("display lists",{colorByFields:t.colorByFields,traitFields:t.traitFields}),t.labelColors=K(t.fields,Ae),t.colorScalePlasmaColorsArray=h["range"](0,1.01,.1).map((function(e){return t.colorscaleGreyBlue(e)})).join(", "),D=Object.keys(t.fields.metadata_labels),O=null===(o=t.displayGroups)||void 0===o||null===(o=o.cellType)||void 0===o?void 0:o[0],O&&D.includes(O)?t.cellTypeField=O:t.cellTypeField=t.findCellTypeField(D),t.activeGroup=t.cellTypeField,m("cellTypeField:",t.cellTypeField),L=null===(s=t.displayGroups)||void 0===s?void 0:s.samples,L&&D.includes(L)?(t.samplesField=L,t.aggregateField=t.samplesField,t.aggregateType="sample"):t.samplesField=t.findSamplesField(D),m("samplesField:",t.samplesField),j=null===(c=t.displayGroups)||void 0===c?void 0:c.donors,j&&D.includes(j)?(t.donorsField=j,t.fields.metadata_labels[t.donorsField].length>1&&(t.aggregateField=t.donorsField,t.aggregateType="donor")):t.donorsField=t.findDonorsField(D),m("donorsField:",t.donorsField),m("aggregates",{field:t.aggregateField,type:t.aggregateType}),m("++++++++++++ PLOTTING"),t.selectColorBy(t.cellTypeField),t.selectSegmentBy(t.cellTypeField,""),t.geneExpressionVars.selectedLabel=t.cellTypeField,t.dataReady=!0,e.next=101,p["default"].nextTick();case 101:if(S=!1,null===(d=t.renderConfig["parameters"])||void 0===d||!d.gene){e.next=151;break}if(T=decodeURIComponent(f["a"][t.renderConfig["parameters"].gene]),!T||"undefined"===T){e.next=129;break}m("loading param genes"),R=T.split(","),G=Object(l["a"])(R),e.prev=108,G.s();case 110:if((W=G.n()).done){e.next=119;break}return U=W.value,e.next=114,t.getGeneExpression(U.toUpperCase(),!1);case 114:return e.next=116,p["default"].nextTick();case 116:S=!0;case 117:e.next=110;break;case 119:e.next=124;break;case 121:e.prev=121,e.t0=e["catch"](108),G.e(e.t0);case 124:return e.prev=124,G.f(),e.finish(124);case 127:e.next=151;break;case 129:if(null===(A=t.presetsConfig)||void 0===A||!A["genes"]){e.next=151;break}m("loading config genes"),q=Object(l["a"])(t.presetsConfig["genes"]),e.prev=132,q.s();case 134:if((N=q.n()).done){e.next=143;break}return V=N.value,e.next=138,t.getGeneExpression(V.toUpperCase(),!1);case 138:return e.next=140,p["default"].nextTick();case 140:S=!0;case 141:e.next=134;break;case 143:e.next=148;break;case 145:e.prev=145,e.t1=e["catch"](132),q.e(e.t1);case 148:return e.prev=148,q.f(),e.finish(148);case 151:if(S){e.next=178;break}if(!t.markerGenes){e.next=157;break}return e.next=155,t.getGeneExpression(t.markerGenes[0].gene.toUpperCase(),!1);case 155:e.next=178;break;case 157:if(!t.markersList){e.next=178;break}m("loading marker genes"),z=Object(l["a"])(t.markersList),e.prev=160,z.s();case 162:if(($=z.n()).done){e.next=170;break}return H=$.value,e.next=166,t.getGeneExpression(H.toUpperCase(),!1);case 166:return e.next=168,p["default"].nextTick();case 168:e.next=162;break;case 170:e.next=175;break;case 172:e.prev=172,e.t2=e["catch"](160),z.e(e.t2);case 175:return e.prev=175,z.f(),e.finish(175);case 178:case"end":return e.stop()}}

1),e,null,[[108,121,124,127],[132,145,148,151],[160,172,175,178]])})))()},initMarkers:function(t){var e=this;return Object(c["a"])(Se().mark((function n(){var r,a,i,o,l,c,d,p,f,_,g;return Se().wrap((function(n){while(1)switch(n.prev=n.next){case 0:if(r=e.selectedBI+e.BIendpoints.markers+t.output_file,!r){n.next=11;break}return a=r,n.next=5,W(a,e.datasetId);case 5:i=n.sent,o=i.filter((function(t){return null!==t})),l=o.map((function(t){var e,n,r,a;return Object(s["a"])(Object(s["a"])({},t),{},{mean_expression:null!==(e=null!==(n=t.mean_expression)&&void 0!==n?n:t.mean_expression_raw)&&void 0!==e?e:0,pct_cells_expression:null!==(r=null!==(a=t.pct_cells_expression)&&void 0!==a?a:t.pct_nz_group)&&void 0!==r?r:0})})),e.markers=l,m("markers",e.markers),e.markers?Array.isArray(e.markers)?(e.markersList=Object(u["a"])(new Set(e.markers.map((function(t){return t.gene.toUpperCase()})))),e.markerCellTypes=(null===(c=e.fields.metadata_labels_sorted)||void 0===c?void 0:c[t.marker_gene_level])||e.fields.metadata_labels[t.marker_gene_level],e.markersByGene=tt(e.markers,"gene"),e.markersByCellType=tt(e.markers,t.markerKey),d=80/e.markerCellTypes.length,p=e.topNmarkersByCellType(d),f=p.markersMatrix,_=p.markersTable,e.geneNames=e.markersList,e.markerGenes=f,e.markerGenesTable=_,e.markerGenesMaxMean=h["max"](e.markerGenes.map((function(t){return t.mean_expression}))).toFixed(1),e.markerTableColumns=e.markerDesiredColumns.filter((function(t){return e.markerGenes.some((function(e){return null!==e[t.key]&&void 0!==e[t.key]}))})),e.markersHaveZscores=e.markerGenes.some((function(t){return null!==t.z_score&&void 0!==t.z_score})),m("markers",{markersByGene:e.markersByGene,markersByCellType:e.markersByCellType,markerGenes:e.markerGenes,markersList:e.markersList})):(g=Object.values(e.markers).flat(),e.markersList=g,m({markersList:g})):m("no markers returned");case 11:case"end":return n.stop()}}),n)})))()},getGeneExpression:function(t){var e=arguments,n=this;return Object(c["a"])(Se().mark((function r(){var a,i,o,s,l;return Se().wrap((function(r){while(1)switch(r.prev=r.next){case 0:if(a=!(e.length>1&&void 0!==e[1])||e[1],i=e.length>2&&void 0!==e[2]&&e[2],!n.geneNames.includes(t)){r.next=8;break}if(m("".concat(t," already listed")),!n.expressionData[t]){r.next=8;break}return m("".concat(t," already loaded")),i&&n.geneClick(t),r.abrupt("return");case 8:return n.geneLoading="gene",o=n.selectedBI+n.BIendpoints.expression,r.next=12,q(o,t,n.datasetId);case 12:if(s=r.sent,n.geneLoading=null,!s){r.next=24;break}return(n.markerGenes&&!n.markersList.includes(t)||!n.markerGenes)&&n.geneNames.push(t),p["default"].set(n.expressionData,t,s),m("getGeneExpression",t),a&&null!==(l=n.renderConfig["parameters"])&&void 0!==l&&l.gene&&f["a"].set(Object(d["a"])({},n.renderConfig["parameters"].gene,t)),r.next=21,p["default"].nextTick();case 21:n.geneExpressionVars.selectedGene&&!i||n.geneClick(t),r.next=27;break;case 24:return n.genesNotFound.includes(t)||n.genesNotFound.push(t),r.next=27,p["default"].nextTick();case 27:case"end":return r.stop()}}),r)})))()},maxCountValue:function(){var t=h["max"](this.cellCompositionVars.segmentByCounts2,(function(t){return t.count}));return t},minExpressionValue:function(t){return h["min"](this.expressionData[t])},maxExpressionValue:function(t){return h["max"](this.expressionData[t])},getPlotMetadataLabels:function(t){var e,n;if(!t||!this.fields)return[];var r=(null===(e=this.fields["metadata_labels_sorted"])||void 0===e?void 0:e[t])||(null===(n=this.fields["metadata_labels"])||void 0===n?void 0:n[t])||[];return r.filter((function(t){return!A(t)}))},getStatsByPropValue:function(t,e,n){return t.filter((function(t){return t[e]===n}))},getAllStats:function(){var t,e=[],n=this.getPlotMetadataLabels(this.cellCompositionVars.segmentByLabel),r=Object(l["a"])(n);try{for(r.s();!(t=r.n()).done;){var a=t.value,i=this.getStatsByPropValue(this.geneExpressionVars.expressionStats,this.cellCompositionVars.segmentByLabel,a);e.push.apply(e,Object(u["a"])(i))}}catch(o){r.e(o)}finally{r.f()}return e},stratifyPlotTypeLabel:function(t){var e={violin:"Violin list",comb

1ined:"Combined violin",dot:"Dot plot"};return e[t]||t},swapCountLabels:function(){var t=this.cellCompositionVars.displayByLabel,e=this.cellCompositionVars.segmentByLabel;this.cellCompositionVars.displayByLabel=e,this.cellCompositionVars.segmentByLabel=t},swapExpressionLabels:function(){var t=this.geneExpressionVars.selectedLabel,e=this.geneExpressionVars.subsetLabel;this.geneExpressionVars.selectedLabel=e,this.geneExpressionVars.subsetLabel=t},findCellTypeField:function(t){return t.reduce((function(t,e){var n=e.toLowerCase(),r=(n.includes("cell")?1:0)+(n.includes("type")?1:0)+(n.includes("cluster")?1:0);return r>t.score?{string:e,score:r}:t}),{string:null,score:0}).string},findDonorsField:function(t){return t.reduce((function(t,e){var n=e.toLowerCase(),r=(n.includes("donor")?2:0)+(n.includes("subject")?1:0)+(n.includes("individual")?1:0)+(n.includes("participant")?1:0)+(n.includes("patient")?1:0)+(n.includes("library")?1:0)+(n.includes("id")?.5:0);return r>t.score?{string:e,score:r}:t}),{string:null,score:0}).str

1ing},findSamplesField:function(t){return t.reduce((function(t,e){var n=e.toLowerCase(),r=(n.includes("sample")?2:0)+(n.includes("specimen")?1:0)+(n.includes("id")?.5:0);return r>t.score?{string:e,score:r}:t}),{string:null,score:0}).string},displayLabel:function(t){var e;return null!==(e=this.displayFields)&&void 0!==e&&e[t]?this.displayFields[t].displayName:t},topNmarkersByCellType:function(t){var e,n=this,r=arguments.length>1&&void 0!==arguments[1]?arguments[1]:null,a=[],i=[],o=[],c=this.markerCellTypes,u=Object(l["a"])(c);try{for(u.s();!(e=u.n()).done;){var h=e.value,p=h,f=this.markersByCellType[h];if(!r||r&&p===r){f&&(o=f.every((function(t){return null!=t.z_score}))?f.sort((function(t,e){return e.z_score-t.z_score})).filter((function(t){return t.z_score>0})):f.sort((function(t,e){return e.mean_expression-t.mean_expression})).filter((function(t){return t.mean_expression>0}))),t&&(o=o.slice(0,t));var _,g=Object(l["a"])(o);try{for(g.s();!(_=g.n()).done;){var m,v=_.value,y=[],b=Object(l["a"])(c);try{var x=function(){var t=m.value,e=n.markersByGene[v.gene].find((function(e){return e[n.markerFile.markerKey]===t}));e?y.push(e):y.push(Object(d["a"])(Object(d["a"])(Object(d["a"])(Object(d["a"])({},n.markerFile.markerKey,t),"gene",v.gene),n.markerGenesSizeKey,"0"),"mean_expression",0))};for(b.s();!(m=b.n()).done;)x()}catch(w){b.e(w)}finally{b.f()}a.push.apply(a,y),i.push(Object(s["a"])({},v))}}catch(w){g.e(w)}finally{g.f()}}}}catch(w){u.e(w)}finally{u.f()}return{markersMatrix:a,markersTable:i}},filterRawFields:function(t){},filterDisplayFields:function(){var t=arguments.length>0&&void 0!==arguments[0]&&arguments[0];if(!this.displayFields){var e={};Object.entries(this.fields.metadata_labels).forEach((function(t){var n=Object(o["a"])(t,2),r=n[0],a=n[1];a.length<2?e[r]={displayName:r,dataType:"cat",display:!1,excludeReason:"1value"}:r.toLowerCase().includes("ontology")?e[r]={displayName:r,dataType:"cat",display:!1,excludeReason:"ontologyID"}:e[r]={displayName:r,dataType:et(a),display:!0,excludeReason:null}})),this.displayFields=e}var n,r=Object.entries(this.displayFields).sort((function(t,e){var n,r=Object(o["a"])(t,2),a=r[1],i=Object(o["a"])(e,2),s=i[1];return null===(n=a.displayName)||void 0===n?void 0:n.localeCompare(s.displayName)})),a={},i={},s=Object(l["a"])(r);try{for(s.s();!(n=s.n()).done;){var c=Object(o["a"])(n.value,2),u=c[0],d=c[1];if(t){var h,p,f;if(null!==(h=this.displayGroups)&&void 0!==h&&null!==(h=h.cellType)&&void 0!==h&&h.includes(u)){i[u]=d;continue}if(null!==(p=this.displayGroups)&&void 0!==p&&null!==(p=p.donors)&&void 0!==p&&p.includes(u)){i[u]=d;continue}if(null!==(f=this.displayGroups)&&void 0!==f&&null!==(f=f.samples)&&void 0!==f&&f.includes(u)){i[u]=d;continue}}!1===d.display||d.excludeReason&&void 0!==d.excludeReason?i[u]=d:a[u]=d}}catch(g){s.e(g)}finally{s.f()}var _={show:a,hide:i};return _},handleSampleChange:function(){this.cellTypeField=this.activeGroup,this.selectSegmentBy(this.cellTypeField,this.cellCompositionVars.segmentByLabel)},handleMarkerFileChange:function(){m("changing markers file",this.markerFile),this.dotPlotCellType="",this.initMarkers(this.markerFile)},showMarkersByCellType:function(t){if(""!=t){var e=this.topNmarkersByCellType(80,t),n=e.markersMatrix,r=e.markersTable;this.markerGenes=n,this.markerGenesTable=r}else{var a=this.topNmarkersByCellType(80/this.markerCellTypes.length),i=a.markersMatrix,o=a.markersTable;this.markerGenes=i,this.markerGenesTable=o}},selectBioIndex:function(t){var e;this.datasetId=null,f["a"].set(Object(d["a"])({},null===(e=this.renderConfig["parameters"])||void 0===e?void 0:e.datasetId,null)),this.dataLoaded=!1,this.dataReade=!1,this.allMetadata=null,this.metadata=null,this.fields=null,this.coordinates=null,this.layout=-1,this.selecedBI=t,f["a"].set({bioIndex:t}),this.getBImetadata()},selectDataset:function(t){this.handleSelectEvent({id:this.sectionId,value:t})},handleSelectEvent:function(t){if(t.id===this.sectionId){var e,n;if(m(this.sectionId,"Received on-select event:",t),this.datasetId=t.value,null!==(e=this.renderConfig["parameters"])&&void 0!==e&&e.datasetId)f["a"].set(Object(d["a"])({},null===(n=this.renderConfig["parameters"])||void 0===n?void 0:n.datasetId,this.datasetId));this.init()}},selectLayout:function(t){this.layout=Number(t),f["a"].set({layout:this.layout})},selectColorBy:function(t){m("color by:",t),this.cellCompositionVars.colorByField=t},selectSegmentBy:function(t,e){var n=this.cellCompositionVars;this.contExprResults=null,this.contCountResults=null,m("segment 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r=this.cellCompositionVars;m("segment by:",{display:t,segment:e,facet:n}),r.displayByLabel=t,r.segmentByLabel=e,r.facetByLabel=n,r.segmentByCounts2=z(this.fields,this.labelColors,r.displayByLabel,r.segmentByLabel,r.facetByLabel)},selectExpressionBy:function(t,e){var n=this.geneExpressionVars;m("expression by:",{display:t,segment:e}),n.selectedLabel=t,n.subsetLabel=e,n.expressionStats=X(this.fields,this.labelColors,this.expressionData[n.selectedGene],n.selectedGene,n.selectedLabel,n.subsetLabel)},searchGene:function(t){var e=this,n=t.split(/[,\s]+/);

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1Math.round(d/2)+5,v=g+"-"+m,y={};_this13.renderConfig["hover content"].map((function(e){y[e]=t[e]}));var b={start:Math.round(c/2)-5,end:Math.round(c/2)+5,data:y,name:r,id:t[_this13.renderConfig["render by"]]};_this13.pheWasPosData[v]||(_this13.pheWasPosData[v]=[]),_this13.pheWasPosData[v].push(b)}}}})),d.length>0){var p,f=_this13.hasMultipleYAxisFields?_this13.primaryYAxisField:d[0];if("true"==_this13.renderConfig["convert y -log10"]){var _=f+"-log10";p=void 0!==t[_]?Number(t[_]):null}else p=void 0!==t[f]&&null!==t[f]&&0!=t[f]?Number(t[f]):null;if(null!==p&&!isNaN(p)){var g=-minY+p,m=canvasHeight-plotMargin.bottom-g*yStep,v=_this13.greaterThan?t.rawPValue>=Number(_this13.renderConfig["thresholds"][0]):t.rawPValue<=Number(_this13.renderConfig["thresholds"][0]);0==o&&(s=c);var y=s+24*o;y=c>y?c:y,(0==o||y<l)&&(ctx.font="22px Arial",ctx.fillStyle=v?"#000000":"#00000050",ctx.save(),ctx.translate(y+10,m-24),ctx.rotate(90*-Math.PI/180),ctx.textAlign="start",ctx.fillText(r,0,0),ctx.restore(),ctx.lineWidth=1,ctx.moveTo(c,m),ctx.lineTo(y,m-20),ctx.strokeStyle="#00000080",ctx.stroke()),o++}}dotIndex++}})),r++},_i4=0,_Object$entries4=Object.entries(renderData);_i4<_Object$entries4.length;_i4++)_loop();else for(var _loop2=function(){var t=Object(_home_ec2_user_jenkins_workspace_Portal_Release_node_modules_babel_runtime_helpers_esm_slicedToArray__WEBPACK_IMPORTED_MODULE_0__["a"])(_Object$entries5[_i5],2),e=t[0],n=t[1],r=groupsArr.indexOf(e)%_this13.colors.length,a=_this13.colors[r];pigeanColors[e]=a;var i="#00000075";n.map((function(t){var e=canvasWidth/2,n=canvasHeight/2,r=_this13.renderConfig["render by"],o=null==_this13.phenotypeMapConfig||"kpPhenotypeMap"==_this13.phenotypeMapConfig&&!!_this13.phenotypeMap[t[r]];if(o){t[_this13.renderConfig["beta field"]]&&0!=t[_this13.renderConfig["beta field"]]?_this13.renderTriangle(ctx,e,n,a,i,Math.sign(t[_this13.renderConfig["beta field"]])):_this13.renderDot(ctx,e,n,a,i);var s,l=t[r];"kpPhenotypeMap"==_this13.phenotypeMapConfig?s=_this13.phenotypeMap[l]&&_this13.phenotypeMap[l]["description"]?_this13.phenotypeMap[l]["description"]:l:null==_this13.phenotypeMapConfig&&(s=l);var c=Math.round(n)-5,u=Math.round(n)+5,d=c+"-"+u,h={};_this13.renderConfig["hover content"].map((function(e){h[e]=t[e]}));var p={start:Math.round(e)-5,end:Math.round(e)+5,data:h,name:s};_this13.pheWasPosData[d]||(_this13.pheWasPosData[d]=[]),_this13.pheWasPosData[d].push(p),ctx.font="26px Arial",ctx.fillStyle="#000000",ctx.textAlign="start",ctx.fillText(s,e+15,n);var f=1;_this13.renderConfig["hover content"].map((function(r){ctx.fillText(r+": "+t[r],e+15,n+40*f),f++}))}}))},_i5=0,_Object$entries5=Object.entries(renderData);_i5<_Object$entries5.length;_i5++)_loop2();this.$emit("pigeanColors",pigeanColors)}}},renderDot:function(t,e,n,r,a){t.beginPath(),t.arc(e,n,10,0,2*Math.PI),t.fillStyle=r,t.fill(),t.lineWidth=1,t.strokeStyle=a,t.stroke()},renderShape:function(t,e,n,r,a,i){t.beginPath();var o=10;"circle"===i?t.arc(e,n,o,0,2*Math.PI):"square"===i?t.rect(e-o,n-o,2*o,2*o):"diamond"===i?(t.moveTo(e,n-o),t.lineTo(e+o,n),t.lineTo(e,n+o),t.lineTo(e-o,n),t.closePath()):t.arc(e,n,o,0,2*Math.PI),t.fillStyle=r,t.fill(),t.lineWidth=1,t.strokeStyle=a,t.stroke()},renderTriangle:function(t,e,n,r,a,i){t.beginPath(),1==i&&(t.moveTo(e-10,n+10),t.lineTo(e+10,n+10),t.lineTo(e,n-10)),-1==i&&(t.moveTo(e-10,n-10),t.lineTo(e,n+10),t.lineTo(e+10,n-10)),t.closePath(),t.fillStyle=r,t.fill(),t.lineWidth=1,t.strokeStyle=a,t.stroke()},renderTicksByGroup:function(t,e,n,r,a,i){for(var o=Object.keys(i).sort(),s=0,l=0,c=Object.entries(i);l<c.length;l++){var u=Object(_home_ec2_user_jenkins_workspace_Portal_Release_node_modules_babel_runtime_helpers_esm_slicedToArray__WEBPACK_IMPORTED_MODULE_0__["a"])(c[l],2),d=(u[0],u[1]);s+=d}switch(t.beginPath(),t.lineWidth=1,t.strokeStyle="#000000",t.font="22px Arial",t.fillStyle="#000000",t.setLineDash([]),a){case"x":for(var h=(e-r.left-r.right)/s,p=0,f=0,_=Object.entries(i);f<_.length;f++){var g=Object(_home_ec2_user_jenkins_workspace_Portal_Release_node_modules_babel_runtime_helpers_esm_slicedToArray__WEBPACK_IMPORTED_MODULE_0__["a"])(_[f],2),m=g[0],v=g[1];if(v>0){var y=r.left+(p+.5)*h,b=Math.floor(y);t.moveTo(b,n-r.bottom+r.bump),t.lineTo(b,n-r.bottom+2*r.bump),t.stroke();var x=o.indexOf(m)%this.colors.length;t.fillStyle=this.colors[x],t.save(),t.translate(b,n-r.bottom+2*r.bump),t.rotate(45*Math.PI/180),t.textAlign="start",t.fillText(m,0,15),t.restore(

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null},viewingRegion:function(){if(null==this.region)return null;var t={};t["chr"]=parseInt(this.region.split(":")[0],10);var e=this.region.split(":")[1].split("-"),n=this.region.split(":")[0],r=parseInt(e[0],10),a=parseInt(e[1],10),i=a-r;if(this.regionZoom>0){var o=Math.round(i*(this.regionZoom/200)),s=Math.round(o*(this.regionViewArea/100));t["chr"]=n,t["start"]=r+o+s,t["end"]=a-o+s}else 0==this.regionZoom&&(t["chr"]=n,t["start"]=r,t["end"]=a);return t},searchingParameters:function(){if(null!=this.searchingRegion&&null!=this.searchingPhenotype)return this.searchingRegion+","+this.searchingPhenotype},searchingRegion:function(){var t={},e=this.region.split(":");

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k,M,E=2*document.querySelector("#geneLinksPlotWrapper").clientWidth,D=i+d+h,O=E-2*this.plotMargin.leftMargin,L=11,j=O/(f-p);k=document.querySelector("#geneLinksPlot"),k.setAttribute("width",E),k.setAttribute("height",D),k.setAttribute("style","width:"+E/2+"px;height:"+D/2+"px;"),M=k.getContext("2d"),M.clearRect(0,0,E,D);var S=o,A=Object.keys(this.renderData).sort();A.map((function(n){var r=t.renderData[n];M.font="28px Arial",M.textAlign="left",M.fillStyle="#00000075",M.fillText(n,L,S);var a=0,i=S+c;S=i;var o=0;t.genesArr.map((function(e){if(r[e]){var n=r[e];M.font="24px Arial",M.textAlign="left",M.fillStyle="#000000",M.fillText(e,L,S+c),o%2==0&&(M.fillStyle="#00000010",M.fillRect(t.plotMargin.leftMargin,S,O,c*Object.keys(n).length)),t.methodsArr.map((function(e){if(n[e]){var r=n[e],i=t.methodsArr.indexOf(e),o=t.methodsColors[i];r.map((function(e){var 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s=_this3.renderConfig["y condition"].combination,l=t[_this3.renderConfig["y axis field"]];"greater than"==s&&l>_this3.renderConfig["y condition"]["greater than"]&&a++,"lower than"==s&&l<_this3.renderConfig["y condition"]["lower than"]&&a++,"and"==s&&l>_this3.renderConfig["y condition"]["greater than"]&&l<_this3.renderConfig["y condition"]["lower than"]&&a++,("or"==s&&l>_this3.renderConfig["y condition"]["greater than"]||l<_this3.renderConfig["y condition"]["lower than"])&&a++}switch(a){case 0:ctx.fillStyle="#00000050";break;case 1:ctx.fillStyle="#09910980";break;case 2:ctx.fillStyle="#ff003780";break}function c(t,e,n,r,a){return(t-e)/(n-e)*(a-r)+r}var u=_this3.renderConfig["dot scale"]?c(t[_this3.renderConfig["dot scale"]],dotScaleMin,dotScaleMax,dotSizeMin,dotSizeMax):dotScaleMin;ctx.lineWidth=0,ctx.beginPath(),ctx.arc(n,r,u,0,2*Math.PI),ctx.fill(),_this3.renderConfig["dot label score"]&&a>=_this3.renderConfig["dot label score"]&&(ctx.font="24px 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a=this.extremeVal(this.config.xField),i=this.extremeVal(this.config.yField),s=this.extremeVal(this.config.xField,!1),l=this.extremeVal(this.config.yField,!1),c=s-a,u=l-i;a=a>0?0:a,i=i>0?0:i,this.xMedian=(a+s)/2,this.xScale=o["scaleLinear"]().domain([a-.01*c,s]).range([0,n]),this.svg.append("g").attr("transform","translate(0,".concat(r,")")).call(o["axisBottom"](this.xScale)),this.svg.append("text").attr("text-anchor","middle").attr("font-size","smaller").attr("y",r+e.top+22).attr("x",n/2).text(this.config.xAxisLabel||this.config.xField),this.yScale=o["scaleLinear"]().domain([i-.05*u,l]).range([r,0]),this.svg.append("g").call(o["axisLeft"](this.yScale)),this.svg.append("text").attr("text-anchor","middle").attr("transform","rotate(-90)").attr("font-size","smaller").attr("y",20-e.left).attr("x",-r/2-e.top).text(this.config.yAxisLabel||this.config.yField),this.svg.append("g").selectAll("dot").data(this.chartData).enter().append("circle").attr("class",(function(e){return t.dotClassId(e[t.config.dotKey])})).attr("cx",(function(e){return void 0===e[t.config.xField]?t.xScale(0):t.xScale(e[t.config.xField])})).attr("cy",(function(e){return void 0===e[t.config.yField]?t.yScale(0):t.yScale(e[t.config.yField])})).attr("r",5).attr("fill",(function(e){return"".concat(t.dotColor(e.phenotype),"aa")})).attr("stroke",this.dotOutlineColor).on("mouseover",(function(e){return t.hoverDot(JSON.stringify(e))})),this.svg.selectAll("circle").on("click",(function(e){t.tooltipPinned||(t.tooltipPinned=!0)}))},extremeVal:function(t){var e=!(arguments.length>1&&void 0!==arguments[1])||arguments[1],n=this.pigeanData.filter((function(e){return void 0!==e[t]&&!Number.isNaN(e[t])})),r=n[0][t];return n.forEach((function(n){(e&&n[t]<r||!e&&n[t]>r)&&(r=n[t])})),r},hoverDot:function(t){var e=this;if(!this.tooltipPinned){this.unHoverDot(),this.$emit("dotsHovered",t);var 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Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.