1"use strict";(self.webpackChunk_N_E=self.webpackChunk_N_E||[]).push([[1355],{1355:(e,t,i)=>{i.r(t),i.d(t,{default:()=>d});var n=i(67684),s=i(62701),r=i(37876),o=i(91668);i(80727);var a=i(33086),l=i(6672),c=i(32996);function h(e){var t=(0,n._)({a:"a",em:"em",h2:"h2",h3:"h3",li:"li",p:"p",strong:"strong",ul:"ul"},(0,o.R)(),e.components),i=t.Mut,s=t.VarOrLin;return i||m("Mut",!0),s||m("VarOrLin",!0),(0,r.jsxs)(r.Fragment,{children:[(0,r.jsx)(t.h2,{id:"mutation-information",children:"Mutation Information"}),"\n",(0,r.jsxs)(t.ul,{children:["\n",(0,r.jsxs)(t.li,{children:[(0,r.jsx)(l.lZ,{mut:"S:H69-"})," (nucleotides: ",(0,r.jsx)(c.x6,{mut:"C21767-"}),", ",(0,r.jsx)(c.x6,{mut:"A21768-"}),", ",(0,r.jsx)(c.x6,{mut:"T21769-"}),")"]}),"\n"]}),"\n",(0,r.jsx)(t.h3,{id:"sh69-",children:"S:H69-"}),"\n",(0,r.jsxs)(t.p,{children:[(0,r.jsx)(l.lZ,{mut:"S:H69-"})," has arisen 3 times in association with other mutations and variants: ",(0,r.jsx)(i,{name:"S:Y453F"}),", ",(0,r.jsx)(s,{name:"20A/S:439K"}),", ",(0,r.jsx)(s,{name:"20I (Alpha, V1)"})," (",(0,r.jsx)(a.e,{href:"https://www.biorxiv.org/content/10.1101/2020.12.14.422555v6",children:"Kemp et al. bioRxiv"}),"); and has additionally arisen multiple times outside of these variants.",(0,r.jsx)("br",{}),(0,r.jsx)("br",{})]}),"\n",(0,r.jsxs)(t.ul,{children:["\n",(0,r.jsxs)(t.li,{children:[(0,r.jsx)(l.lZ,{mut:"S:H69-"})," may alter the recognition by antibodies, possibly impacting some antibody-therapy treatments, or immunity (",(0,r.jsx)(a.e,{href:"https://www.nature.com/articles/s41586-021-03291-y",children:"Kemp et al. - Nature"}),")."]}),"\n",(0,r.jsxs)(t.li,{children:["In particular, the deletion is predicted structurally to 'tuck in' the Spike N-terminal domain (",(0,r.jsx)(a.e,{href:"https://www.biorxiv.org/content/10.1101/2020.12.14.422555v6",children:"Kemp et al. bioRxiv"}),")"]}),"\n",(0,r.jsxs)(t.li,{children:["In one study, was identified as a 'recurrent deletion region' (found multiple times in public sequences), but did not impact the 2 monoclonal antibodies tested (",(0,r.jsx)(t.a,{href:"https://science.sciencemag.org/content/371/6534/1139",children:"McCarthey et al., Science"}),")"]}),"\n",(0,r.jsxs)(t.li,{children:["Appeared in a chronically infected immunosuppressed patient treated with rituximab monoclonal antibodies (along with ",(0,r.jsx)(s,{name:"S:Y453F"}),") (",(0,r.jsx)(t.a,{href:"https://virological.org/t/emergence-of-y453f-and-69-70hv-mutations-in-a-lymphoma-patient-with-long-term-covid-19/580",children:"Bazykin et al., Virological"}),")"]}),"\n"]}),"\n",(0,r.jsxs)(t.p,{children:["Note: the protein figure shows deletions at both positions 69 & 70 (",(0,r.jsx)(l.lZ,{mut:"S:H69-"}),", ",(0,r.jsx)(l.lZ,{mut:"S:V70-"}),")."]}),"\n",(0,r.jsxs)(t.p,{children:[(0,r.jsx)(t.strong,{children:"Important"}),": ",(0,r.jsx)(t.em,{children:"Currently this build detects only the deletion at position 69 in spike, as due to alignment/calling differences, detecting the deletion at position 70 is less reliable. However, they seem to be highly associated."})]})]})}function d(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},t=(0,n._)({},(0,o.R)(),e.components).wrapper;return t?(0,r.jsx)(t,(0,s._)((0,n._)({},e),{children:(0,r.jsx)(h,(0,n._)({},e))})):h(e)}function m(e,t){throw Error("Expected "+(t?"component":"object")+" `"+e+"` to be defined: you likely forgot to import, pass, or provide it.")}}}]); 2//# sourceMappingURL=1355.b7fc79e4d5f496db.js.map
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