1"use strict";(self.webpackChunk_N_E=self.webpackChunk_N_E||[]).push([[6144],{86144:(e,n,a)=>{a.r(n),a.d(n,{default:()=>h});var i=a(67684),t=a(62701),s=a(37876),r=a(91668),o=a(17691),d=a(6672),l=a(47195);function c(e){var n=(0,i._)({a:"a",br:"br",code:"code",li:"li",p:"p",ul:"ul"},(0,r.R)(),e.components);return(0,s.jsxs)(s.Fragment,{children:[(0,s.jsxs)(n.p,{children:["The Pango lineage ",(0,s.jsx)(n.code,{children:"B.1.617"})," includes both ",(0,s.jsx)(o.Q,{name:"21B (Kappa)"})," and its sister lineage ",(0,s.jsx)(o.Q,{name:"21A (Delta)"}),".",(0,s.jsx)(n.br,{}),"\n",(0,s.jsx)(n.code,{children:"B.1.617"})," was first detected in late 2020 in India, and has appeared to expand rapidly."]}),"\n",(0,s.jsxs)(n.p,{children:["These sequences have Spike mutations at positions ",(0,s.jsx)(d.lZ,{mut:"S:L452R"})," (see ",(0,s.jsx)(o.Q,{name:"21C (Epsilon)"})," page for more details) and ",(0,s.jsx)(l.lG,{name:"S:P681"}),", both of which impact antibody binding."]}),"\n",(0,s.jsxs)(n.p,{children:["In addition, many sequences have mutation ",(0,s.jsx)(d.lZ,{mut:"S:G142D"}),", in the N-terminal domain, which is an escape mutant to some antibodies (",(0,s.jsx)(n.a,{href:"https://www.biorxiv.org/content/10.1101/2021.01.14.426475v1",children:"McCallum et al., bioRxiv"}),") and has appeared in viruses grown in the presence of a monoclonal antibody (",(0,s.jsx)(n.a,{href:"https://www.cell.com/cell/fulltext/S0092-8674(21)00357-3",children:"Suryadevara et al., Cell"}),")."]}),"\n",(0,s.jsx)(n.p,{children:"These sequences therefore have mutations in the N-terminal domain, receptor binding domain (RBD), and furin cleavage site of the spike protein, which could impact a variety of antibodies."}),"\n",(0,s.jsxs)(n.ul,{children:["\n",(0,s.jsxs)(n.li,{children:["A study found that titers against ",(0,s.jsx)(n.code,{children:"B.1.617"})," were reduced roughly 2-fold compared to ",(0,s.jsx)(o.Q,{name:"20I (Alpha, V1)",prefix:""})," and wild-type (",(0,s.jsx)(n.a,{href:"https://www.biorxiv.org/content/10.1101/2021.04.23.441101v1",children:"Yadav et al., bioRxiv"}),")"]}),"\n"]})]})}function h(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{},n=(0,i._)({},(0,r.R)(),e.components).wrapper;return n?(0,s.jsx)(n,(0,t._)((0,i._)({},e),{children:(0,s.jsx)(c,(0,i._)({},e))})):c(e)}}}]); 2//# sourceMappingURL=6144.81e83e9f391b9082.js.map
Line numbers count LF bytes from the start of the resource, as the search results do. Vendor segments are library code the classifier recognised; they are stored but not indexed. Bytes are shown as Latin1 characters, one per byte.