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56<!-- End Google Tag Manager (noscript) --><div id="container"><header id="header"><div id="top-nav"><div class="container"><div id="user-bar"><div class="pull-left"><span>Have a website account?<a class="btn-login" href="http://www.chinaphar.com/login">Log In</a> or<a class="btn-login btn-register" href="http://www.chinaphar.com/user/register">Register</a> for exclusive website content.</span></div> 57 <div class="pull-right hidden-phone"> 58 <a class="btn-login" target="_blank" title="Subscribe" href="https://news.amepc.org/h/t/63F6F272C7331020"><span class="icon-envelop"></span> Subscribe</a> 59 </div> 60 </div></div></div><div class="container"><div class="container"><div class="pull-left"><h1 id="logo"><a href="http://www.chinaphar.com/"title="Acta Pharmacologica Sinica" ><img class="img-title" src="//cdn.amegroups.cn/journals/aps/public/journals/26/homeHeaderTitleImage_en_US.png/w1400?v=20261002" alt="" onerror="this.style.display='none'"/></a></h1></div><div id="search-form" class="pull-right"><form method="post" action="http://www.chinaphar.com/search/advancedResults" class="form-horizontal"><input type="hidden" name="searchField" value=""><div class="control-group"><div class="inline-block hidden-phone hidden-tablet"><input type="radio" checked="true" value="title" id="search-title" name="search-type"><label for="search-title">Title</label><input type="radio" value="author" id="search-author" name="search-type"><label for="search-author">Author</label></div><div class="input-append"><input type="text" id="query" name="query" placeholder="Search" maxlength="255" value="" class="span3"/><input type="submit" value="Go" class="btn"/></div><div class="text-right"><a href="http://www.chinaphar.com/search" style="margin-left: 10px;">Advanced Search</a></div></div></form></div></div><nav id="nav"> 61 <ul class="clearfix"> 62 <li><a href="http://www.chinaphar.com/index">Home</a></li> 63 <li> 64 <a href="#">Journal Info</a> 65 <ul class="clearfix"> 66 <li><a href="http://www.chinaphar.com/about">About the Journal</a></li> 67 <li><a target= "_blank" href="/pages/view/aps-instruction-for-authors">Author Instruction</a></li> 68 <li><a href="http://www.chinaphar.com/about/editorInChief">Editor-in-Chief</a></li> 69 <li><a href="http://www.chinaphar.com/about/editorialTeam">Editorial Board</a></li> 70 <li><a href="http://www.chinaphar.com/pages/view/acknowledgementToReviewers">Acknowledgements</a></li> 71 </ul> 72 </li> 73 74 <li><a href="http://www.chinaphar.com/issue/archive">Archives</a></li> 75 <li><a target= "_blank" href="https://www.nature.com/aps/focuses">Special Issue</a></li> 76 <li><a target= "_blank" href="http://www.nature.com/aps/journal/vaop/ncurrent/index.html">Advance Online Publication (AOP)</a></li> 77 78 <li><a href="http://www.chinaphar.com/announcement">Announcements</a></li> 79 <li><a href="http://www.chinaphar.com/pages/view/Contact-US">Contact Us</a></li> 80 81 82 83 84 </ul> 85</nav> 86</div></header><div id="wrapper" role="main"><div class="container"><div id="breadcrumb"> 87 <ul class="breadcrumb"> 88 <li> 89 <a href="http://www.chinaphar.com/index">Home</a> 90 <span class="divider">/</span></li> 91 92 93 <li>Home</li> 94 95 </ul> 96</div> 97 98 <div id="carousel" class="carousel slide hidden-phone"> 99 <ol class="carousel-indicators"> 100 <li data-target="#myCarousel" data-slide-to="0" class="active"></li> 101 <li data-target="#myCarousel" data-slide-to="1" class=""></li>
102 <li data-target="#myCarousel" data-slide-to="2" class=""></li> 103 <li data-target="#myCarousel" data-slide-to="3" class=""></li> 104 <li data-target="#myCarousel" data-slide-to="4" class=""></li> 105 <li data-target="#myCarousel" data-slide-to="5" class=""></li> 106 <li data-target="#myCarousel" data-slide-to="6" class=""></li> 107 <li data-target="#myCarousel" data-slide-to="7" class=""></li> 108 <li data-target="#myCarousel" data-slide-to="8" class=""></li> 109 <li data-target="#myCarousel" data-slide-to="9" class=""></li> 110 </ol> 111 <div class="carousel-inner"> 112 <div class="item active" id="item-0"> 113 <div class="media"> 114 <div class="media-body"> <h3 class="media-heading"> <a href="http://www.chinaphar.com/announcement/view/157">Call for preprint papers | ChinaXiv-Pharmaceutical Science</a></h3> <p>ChinaXiv-Pharmaceutical Science (<a href="https://phar.chinaxiv.org/" target="_blank">https://phar.chinaxiv.org/</a>) was jointly constructed by Shanghai Institute of Materia Medica, Chinese Academy of Sciences and the ChinaXiv team (ChinaXiv is a national preprint e-infrastructure constructed by National Science Library, Chinese Academy of Sciences in 2016 according to the deployment of Chinese Academy of Sciences). The platform was officially launched and released on November 3, 2023.</p> <p> <a href="http://www.chinaphar.com/announcement/view/157" class="read-more">Read More>></a> </p></div> 115 </div> 116 </div> 117 <div class="item " id="item-1"> 118 <div class="media"> 119 <div class="media-body"><h3 class="media-heading"> <a href="http://www.chinaphar.com/announcement/view/158">2025 APS Outstanding Contribution Awards</a> </h3> <p>APS (<em>Acta Pharmacologica Sinica</em>), published monthly in English, is an international peer-reviewed journal. With the leading by Professor <a href="http://www.chinaphar.com/about/editorInChief">Jian Ding</a>, Editor-in-Chief, and the support from a respected global <a href="http://www.chinaphar.com/about/editorialTeam">editorial board</a>, APS is continuously growing to a high-level journal in the area of pharmacology and related life sciences. We owe all the journal progress to our authors and reviewers. To acknowledge their fine contributions to the journal, we set awards to outstanding papers and reviewers.</p><p> <a href="http://www.chinaphar.com/announcement/view/158" class="read-more">Read More>></a> </p></div> 120 </div> 121 </div> 122 <div class="item " id="item-2"> 123 <div class="media"> 124 <div class="pull-left"> <img src="https://cdn.amegroups.cn/static/image/894e9eb580f2be675ec6577e5b398c73/894e9eb580f2be675ec6577e5b398c73.jpg/w600" alt="" style="height: 224px;" align="left" /></div><div class="media-body"> <h3 class="media-heading"> <a href="http://www.chinaphar.com/article/view/10374">FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy</a> </h3> <p> Schematic diagram of the role of FOXO3a in TMZ-induced BNIP3-mediated mitophagy. </p> <p> <a href="http://www.chinaphar.com/article/view/10374" class="read-more">Read More>></a> </p></div> 125 </div> 126 </div> 127 <div class="item " id="item-3"> 128 <div class="media"> 129 <div class="media-body"> <h3 class="media-heading"> <a href="https://www.nature.com/articles/s41401-020-00539-7">A brief guide to good practices in pharmacological experiments: Western blotting</a> </h3> <p><strong> Lu Tie, Han Xiao, Da-lei Wu, Ye Yang & Pei Wang </strong></p><p>Western blotting (WB) is an antibody-based experimental technique used to detect and quantify target proteins, which are often within a complex mixture extracted from cells or tissue. WB remains the most commonly used methodology in the lab for protein detection. However, concerns about WB have been voiced by many scie
129ntific journals in an effort to reduce potential mistakes and increase reproducibility.</p><p>This guide, therefore, aims to provide an updated and more concise and useable reference for future experiments and paper writing.</p> <p> <a href="https://www.nature.com/articles/s41401-020-00539-7" class="read-more">Read More>></a> </p></div> 130 </div> 131 </div> 132 <div class="item " id="item-4"> 133 <div class="media"> 134 <div class="pull-left"> <img src="https://cdn.amegroups.cn/static/image/5ca6f2f117d6d35f53a0386a690894ee/5ca6f2f117d6d35f53a0386a690894ee.jpg/w600" alt="" style="height: 224px;" align="left" /></div><div class="media-body"> <h3 class="media-heading"> <a href="https://www.nature.com/articles/s41401-020-00530-2">The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders</a> </h3> <p> Activation of CB2Rs plays neuroprotective roles, including attenuation of neuroinflammation, amelioration of mitochondrial depolarization and stimulation of neurogenesis, which could eventually reduce deficits in cognition, memory and motor inhibition. In addition, the activation of CB2Rs also modulates ion channel functions, thereby altering neuronal excitability, and leads to neuroprotection. </p> <p> <a href="https://www.nature.com/articles/s41401-020-00530-2" class="read-more">Read More>></a> </p></div> 135 </div> 136 </div> 137 <div class="item " id="item-5"> 138 <div class="media"> 139 <div class="pull-left"> <img src="http://cdn.amegroups.cn/static/image/916f9ba19fd5ed7f32ad3f6258150a8c.png/w600" alt="" style="height: 224px;" align="left" /></div><div class="media-body"> <h3 class="media-heading"> <a href="http://www.chinaphar.com/article/view/10179">FSHR ablation induces depression-like behaviors</a> </h3> <p> The expression of FSHR in depression-related brain regions. a The CA1 region of the mouse hippocampus. b The CA3 region of mouse hippocampus. c The DG of the mouse hippocampus. d The cortex. e The nucleus accumbens. f The amygdala. g The prefrontal cortex. h The bed nucleus of the stria terminalis. i The lateral habenula. FSHR (red), NeuN (green, a marker of neurons), and DAPI (blue) immunofluorescence was detected under a fluorescence microscope. See the article in pages 1033â1040. </p> <p> <a href="http://www.chinaphar.com/article/view/10179" class="read-more">Read More>></a> </p></div> 140 </div> 141 </div> 142 <div class="item " id="item-6"> 143 <div class="media"> 144 <div class="pull-left"> <img src="https://cdn.amegroups.cn/static/image/64002b334b83abf989f3368549038743/64002b334b83abf989f3368549038743.png/w600" alt="" style="height: 224px;" align="left" /></div><div class="media-body"> <h3 class="media-heading"> <a href="https://www.nature.com/articles/s41401-020-0429-z">Nanomedicine-based immunotherapy for central nervous system disorders </a> </h3> <p>Optimal design of nanoparticle-based delivery of drugs, cargoes/or adjuvants, and immunotherapy of glioblastoma. Diverse types of nanoscale materials can serve as vehicles for targeted delivery of tumor-cytotoxic nanomedicines. </p> <p> <a href="https://www.nature.com/articles/s41401-020-0429-z" class="read-more">Read More>></a> </p> </div> 145 </div> 146 </div> 147 <div class="item " id="item-7"> 148 <div class="media"> 149 <div class="pull-left"> <img src="http://cdn.amegroups.cn/static/image/74879515cfb4baef56f26e2f559b4df2.jpg/w600" alt="" style="height: 224px;" align="left" /></div><div class="media-body"> <h3 class="media-heading"> <a href="http://www.chinaphar.com/article/view/10163">Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin</a> </h3> <p> Schematic representation of possible mechanisms of aminoglycosides (AGs)-induced nephrotoxicity and ototoxicity. The schematic diagram mainly includes three parts: (1) AGs are predominantly distributed in the mitochondria of renal tubular cells and inner ear hair cell-like cells; (2) AGs inhibit mitochondrial electron transport chain (ETC) complexes I, IV, and V; and (3) AGs inhibit the PGC-1α-NRF1-TFAM pathway, which may repress mitochondrial biosynthesis. </p> <p> <a href="http://www.chinaphar.com/article/view/10163" class="read-more">Read More>></a> </p></div> 150 </div> 151 </div> 152 <div class="item " id="item-8"> 153 <div class="media"> 154 <div class="pull-left"><img src="/public/attachments/month_1805/201805070637286388.jpg" alt="" align="left" /></div><div class="media-body"><h3 class="media-heading"><a href="https://www.nature.com/articles/aps201833">Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy â an illustration with firsthand examples</a></h3><p>Nanotechnology has been applied extensively in drug delivery to improve the therapeutic outcomes of various diseases. Tremendous efforts have been focused on the development of novel nanoparticles and delineation of the physicochemical properties of nanoparticles in relation to their biological fate and functions. However, in the design and evaluation of these nanotechnology-based drug delivery systems, ...</p></div> 155 </div> 156 </div> 157 <div class="item " id="item-9"> 158 <div class="media"> 159 <div class="pull-left"><img src="/public/attachments/month_1805/201805070640238414.jpg" alt="" align="left" /></div><div class="media-body"><h3 class="media-heading"><a href="https://www.nature.com/articles/aps20185">Discovery and development of NA-1 for the treatment of acute ischemic stroke</a></h3><p>Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be benef
159icial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. ...<br /></p></div> 160 </div> 161 </div> 162 </div> 163 <a class="left carousel-control" href="#carousel" data-slide="prev">â¹</a> 164 <a class="right carousel-control" href="#carousel" data-slide="next">âº</a> 165</div> 166 167
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171 172 173<div class="row-fluid"> 174 <div class="span3 hidden-phone"> 175 176 <div class="current-issue block"> 177 <div id="issue-cover-image"> 178 <a class="cover" href="http://www.chinaphar.com/issue/current/showToc"> 179 <img src="//cdn.amegroups.cn/journals/aps/public/journals/26/cover_issue_667_11_en_US.jpg/w800?v=20261002" 180 alt="Cover Page" 181 /> 182 </a> 183 <p class="date-published"> 184 <a href="http://www.chinaphar.com/issue/current/showToc">Vol 47, No 9 (September, 2026)</a> 185 </p> 186 </div> 187 188 <p><br/></p> 189 <p> 190 CN 31-1347/R <br /> 191 ISSN 1671-4083 <br /> 192 EISSN 1745-7254 193 </p> 194 <p><br/></p> 195 <p>Editor-in-Chief</p> 196 <p><a href="http://www.chinaphar.com/about/editorInChief">Jian Ding</a></p> 197 <p><br/></p> 198 <p> 199 2025 Impact Factor 10.4* 200 </p> 201 <p> 202 16/356 Pharmacology & Pharmacy (Q1) 203 </p> 204 <p> 205 37/250 Chemistry, Multidisciplinary (Q1) 206 </p> 207 <p><br/></p> 208 209 210 <p> 211 *2026 Journal Citation Reports® Science Edition 212 </p> 213 </div> 214 215 <div class="about block"> 216 <!-- <h3>AME Editing Service</h3> 217 <ul> 218 <li><a href="http://editing.amegroups.cn/" target="_blank"> 219 English Editing</a></li> 220 <li><a href="http://editing.amegroups.cn/" target="_blank"> 221 Translation</a></li> 222 </ul> --> 223 224 </div> 225 226 <div class="block publishing-information"> 227 228 <h3> 229 Society Resources 230 </h3> 231 232 <p></p> 233 234 <a target= "_blank" href="http://english.simm.cas.cn/"> 235 <img src="//cdn.amegroups.cn/journals/aps/public/addition/aps/images/SIMM.png/w300" alt="SIMM" /> 236 </a><br /> 237 238 <a target= "_blank" href="http://www.cnphars.org.cn/"> 239 <img src="//cdn.amegroups.cn/journals/aps/public/addition/aps/images/ZGYLXH.png/w300" alt="ZGYLXH" /> 240 </a> 241 </div> 242 243 <div class="block publishing-information"> 244 245 <h3> 246 Publishing Information 247 </h3> 248 249 <p>Acta Pharmacologica Sinica is published by SPRINGER NATURE </p> 250 251 <a target= "_blank" href="http://www.nature.com/aps/index.html"> 252 <img src="//cdn.amegroups.cn/journals/aps/public/addition/aps/images/springer-nature.png/w300" alt="SPRINGER NATURE" /> 253 </a> 254 </div> 255 256 <div class="block publishing-information"> 257 <h3> 258 Membership 259 </h3> 260 261 <p></p> 262 <p>This journal is a member of and subscribes to the principles of the <a href="http://publicationethics.org/"> Committee on Publication Ethics</a>.</p> 263 <a target= "_blank" href="http://publicationethics.org/"> 264 <img src="//cdn.amegroups.cn/journals/aps/public/addition/aps/images/cope-logo.png/w300" alt="COPE" /> 265 </a><br /> 266 </div> 267 268 269 </div> 270 271 <div class="content-main span6"> 272 <ul class="tabs menu" data-tabs="tabs"> 273 <li class="active"><a href="#current-issue" data-toggle="tab">Current Issue</a></li> 274 </ul> 275 276 <div class="pill-content"> 277 <div class="active" id="current-issue"> 278 279 280 <div id="title" style="display: none">Acta Pharmacologica Sinica</div> 281 282 <div class="section"> 283 284 <h3 class="section-title">Research Highlight</h3> 285 286 <div class="article"> 287 288 289 <h5 class="title"> 290 <a class="title" href="http://dx.doi.org/10.1038/s41401-026-01889-4"> 291 Pulsatile FXR activation: Timing bile acid-targeted therapy to physiology 292 </a> 293 294 295 </h5> 296 297 <div class="authors"> 298 Ting-ying Jiao, Yang-tai Li, Frank J. Gonzalez, Cen Xie </div> 299 300 <div class="galleries"> 301 </div> 302 303 </div> 304 </div> 305 <div class="section"> 306 307 <h3 class="section-title">
307Review Article</h3> 308 309 <div class="article"> 310 311 312 <h5 class="title"> 313 <a class="title" href="http://www.chinaphar.com/article/view/11594"> 314 Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions 315 </a> 316 317 <strong style="color:red;">Open</strong> 318 319 320 321 </h5> 322 323 <div class="authors"> 324 Elaine Xue Ning Ong, Chester Yan Jie Ng, Lu-lei Cao, Xuexin Li, Pan P. Li, Nguan Soon Tan, Zehuan Liao, Yan Zhao </div> 325 326 <div class="galleries"> 327 </div> 328 329 </div> 330 331 <div class="article"> 332 333 334 <h5 class="title"> 335 <a class="title" href="http://www.chinaphar.com/article/view/11595"> 336 Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions 337 </a> 338 339 340 </h5> 341 342 <div class="authors"> 343 Ji-zhao Cao, Wei Zhao, Xiao-jun Xia </div> 344 345 <div class="galleries"> 346 </div> 347 348 </div> 349 350 <div class="article"> 351 352 353 <h5 class="title"> 354 <a class="title" href="http://www.chinaphar.com/article/view/11596"> 355 Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease 356 </a> 357 358 <strong style="color:red;">Open</strong> 359 360 361 362 </h5> 363 364 <div class="authors"> 365 Abdallah Iddy Chaurembo, Na Xing, Zi-feng Huang, Baraka Simon Mayamba, Francis Chanda, Yun-tao Liang, Yong-fang Lin, Wen-hui Deng, Jian-yuan Huang, Zeng-yu He, Zheng Tan, Chi Shu, Han-bin Lin </div> 366 367 <div class="galleries"> 368 </div> 369 370 </div> 371 </div> 372 <div class="section"> 373 374 <h3 class="section-title">Article</h3> 375 376 <div class="article"> 377 378 379 <h5 class="title"> 380 <a class="title" href="http://www.chinaphar.com/article/view/11597"> 381 PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress 382 </a> 383 384 <strong style="color:red;">Open</strong> 385 386 387 388 </h5> 389 390 <div class="authors"> 391 Chang-min Wang, Ye Li, Yu-hang Yi, Xiao Chen, Tian Lan, Hai-yan Lou, Wen-cheng Jian, Mei-jian Wang, Shu-yan Yu </div> 392 393 <div class="galleries"> 394 </div> 395 396 </div> 397 398 <div class="article"> 399 400 401 <h5 class="title"> 402 <a class="title" href="http://www.chinaphar.com/article/view/11598"> 403 G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit 404 </a> 405 406 407 </h5> 408 409 <div class="authors"> 410 Hao Wang, Yi-hong Wei, An-qi Gao, Juan-juan Guo, Xin Ding, Jing-jing Yang, Zi-ru Wang, Jun-cheng Da, Yue Kang, Jian-hua Ding, Yi Fan, Ming Lu, Li Zhang, Gang Hu </div> 411 412 <div class="galleries"> 413 </div> 414 415 </div> 416 417 <div class="article"> 418 419 420 <h5 class="title"> 421 <a class="title" href="http://www.chinaphar.com/article/view/11599"> 422 Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation 423 </a> 424 425 426 </h5> 427 428 <div class="authors"> 429 Fang-fang Gao, Yi-fan Xu, Jing Zhang, Shi-meng Qu, Fan Xiao, Jin-qian Cheng, Zhuo-qin Yuan, Guang-ji Wang, Meng-jie Yu, Ji-ye Aa </div> 430 431 <div class="galleries"> 432 </div> 433 434 </div> 435 436 <div class="article"> 437 438 439 <h5 class="title"> 440 <a class="title" href="http://www.chinaphar.com/article/view/11600"> 441 The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit 442 </a> 443 444 445 </h5> 446 447 <div class="authors"> 448 Jun-nan Xu, Jing-ting Li, Ru-xia Xu, Yun-feng Wang, He-wei Gao, Hao-tian He, Han Guo, Yu Liang, Yong-dan Zhu, Xiao-wen Li, Jian-ming Yang, Xiao-ming Li, Yi-hua Chen, Tian-ming Gao </div> 449 450 <div class="galleries"> 451 </div> 452 453 </div> 454 455 <div class="article"> 456 457 458 <h5 class="title"> 459 <a class="title" href="http://www.chinaphar.com/article/view/11601"> 460 Trim47 protects against hypoxicâischaemic brain injury in neonatal rats by reducing brain microvascular endothelial inflammation and BBB disruption by interacting with ZO1 461 </a> 462 463 464 </h5> 465 466 <div class="authors"> 467 Xiao-hui Kong, Zu-bin Zhang, Yu Kong, Da-man Tu, Qian-qian Li, Chen-xi Feng, Xin Ding,
467 Li-xiao Xu, Gen Li, Tao Pan, Zheng-hong Qin, Bin Sun, Xing Feng, Mei Li </div> 468 469 <div class="galleries"> 470 </div> 471 472 </div> 473 474 <div class="article"> 475 476 477 <h5 class="title"> 478 <a class="title" href="http://www.chinaphar.com/article/view/11602"> 479 TIGAR overexpression alleviates intracerebral hemorrhage injury in mice by suppressing ATF4/NOX4/p22phox-mediated oxidative stress and inflammation 480 </a> 481 482 483 </h5> 484 485 <div class="authors"> 486 Yan-yan Li, Jian-rong Yuan, Jie Tang, Lei Chen, Jun-chao Wu, Zheng-hong Qin, Rui Sheng </div> 487 488 <div class="galleries"> 489 </div> 490 491 </div> 492 493 <div class="article"> 494 495 496 <h5 class="title"> 497 <a class="title" href="http://www.chinaphar.com/article/view/11603"> 498 ApoE impairs microglial efferocytosis by targeting Gas6/ MerTK in a mouse model of acute seizure 499 </a> 500 501 502 </h5> 503 504 <div class="authors"> 505 Bo Gao, Si-min Cheng, Yu-yan Zhang, Hui-xia Yang, Ming-ming Hu, Yu Wang, Jian-ming Han, Li Yu, Shun-zhi Cao, Kun Dong, Hua Kong, Wen-ning Wu </div> 506 507 <div class="galleries"> 508 </div> 509 510 </div> 511 512 <div class="article"> 513 514 515 <h5 class="title"> 516 <a class="title" href="http://www.chinaphar.com/article/view/11604"> 517 Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility 518 </a> 519 520 521 </h5> 522 523 <div class="authors"> 524 Cong Wang, Ping-chuan Yuan, Qian Sun, Michael Lazarus, Wei-min Qu, Zhi-li Huang, Feng-fei Ding </div> 525 526 <div class="galleries"> 527 </div> 528 529 </div> 530 531 <div class="article"> 532 533 534 <h5 class="title"> 535 <a class="title" href="http://www.chinaphar.com/article/view/11605"> 536 The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure 537 </a> 538 539 <strong style="color:red;">Open</strong> 540 541 542 543 </h5> 544 545 <div class="authors"> 546 Ke-yu Liu, Ke Gong, Fang Fang, Qing-hua Chen, Jin-rong Xu, Liang-qing Zhang, Wen-liang Chen </div> 547 548 <div class="galleries"> 549 </div> 550 551 </div> 552 553 <div class="article"> 554 555 556 <h5 class="title"> 557 <a class="title" href="http://www.chinaphar.com/article/view/11606"> 558 Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5âVEGF signaling axis in macrophages to alleviate myocardial infarction 559 </a> 560 561 562 </h5> 563 564 <div class="authors"> 565 Ran Wang, Guo-qiang Lin, Fei-yun Wang, Yao Chen, Shou-jiao Peng, Jian-ge Zhang </div> 566 567 <div class="galleries"> 568 </div> 569 570 </div> 571 572 <div class="article"> 573 574 575 <h5 class="title"> 576 <a class="title" href="http://www.chinaphar.com/article/view/11607"> 577 TGF-β2 signaling promotes cardiac fibrosis in arrhythmogenic right ventr
577icular cardiomyopathy mediated by DSC2 deficiency 578 </a> 579 580 581 </h5> 582 583 <div class="authors"> 584 Chen-xing Huang, Ke-jia Jin, Lan-qing Xiang, Zhuo-xin Lv, Ying Wang, Jian-guo Jia, Fei-zhen Wu, Yi-zhun Zhu, Yun-zeng Zou, Yu-xiang Dai, Hui Gong </div> 585 586 <div class="galleries"> 587 </div> 588 589 </div> 590 591 <div class="article"> 592 593 594 <h5 class="title"> 595 <a class="title" href="http://www.chinaphar.com/article/view/11608"> 596 S1UTRSP5, a short restructured RNA from SLIT1 3â²UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity 597 </a> 598 599 600 </h5> 601 602 <div class="authors"> 603 Jin-feng Su, Tao Ou, Xiao-yao Liu, Xue-min Su, Ya Wang, Yi-hong Wen, Yuan Gao, Ruo-han Li, Lu-fang Huang, Chuan-meng Zhou, Heng-li Zhao, Jie-ning Zhu, Ning Ma, Xi-long Zheng, Yu-peng Liu, Jin-dong Xu, Hui Li, Xian-hong Fang, Zhi-xin Shan </div> 604 605 <div class="galleries"> 606 </div> 607 608 </div> 609 610 <div class="article"> 611 612 613 <h5 class="title"> 614 <a class="title" href="http://www.chinaphar.com/article/view/11609">
615 Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis 616 </a> 617 618 619 </h5> 620 621 <div class="authors"> 622 Yang-xian Li, Shu-xiang Ding, Hui-ling Hong, Xiao-yun Cao, Yu-meng Han, Jin-wei Tian, Sin-hang Fung, Stephen Kwok-Wing Tsui, Ya-lan Wu, Xiao Yu Tian </div> 623 624 <div class="galleries"> 625 </div> 626 627 </div> 628 629 <div class="article"> 630 631 632 <h5 class="title"> 633 <a class="title" href="http://www.chinaphar.com/article/view/11610"> 634 CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy 635 </a> 636 637 <strong style="color:red;">Open</strong> 638 639 640 641 </h5> 642 643 <div class="authors"> 644 Ming-chen Sun, Fu-wen Zuo, You-zhao Wang, Xiu-li Ren, Hong-shen Lu, Ming-bo Zheng, Hao-ran Zhang, Han-lin Liu, Cui-cui Lu, Cheng-wu Shen, Ji-chao Wu </div> 645 646 <div class="galleries"> 647 </div> 648 649 </div> 650 651 <div class="article"> 652 653 654 <h5 class="title"> 655 <a class="title" href="http://www.chinaphar.com/article/view/11611"> 656 Few-shot learning-driven discovery of Lutein suppresses Th1- mediated inflammation via glucose metabolism 657 </a> 658 659 660 </h5> 661 662 <div class="authors"> 663 Li-jun Yang, Zong-hui Wei, Pei-jian Cao, Zhi-bin Li, Xiang Li, Jun-wei Zhao, Yi-wen Du, Ke-han Wang, Qiao-hong Zheng, Qiao-jun He, Bo Yang, Jia-jia Wang, Qin-jie Weng </div> 664 665 <div class="galleries"> 666 </div> 667 668 </div> 669 670 <div class="article"> 671 672 673 <h5 class="title"> 674 <a class="title" href="http://www.chinaphar.com/article/view/11612"> 675 Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling 676 </a> 677 678 679 </h5> 680 681 <div class="authors"> 682 Jia-yuan Jin, Yu-xuan Song, Jia-bin Lu, Guan-qun Li, Jun-qiang Wang, Xue-jing Feng, Pei-hua Luo, Bo Yang, Zhi-fei Xu, Hao Yan, Qiao-jun He, Xiao-chun Yang </div> 683 684 <div class="galleries"> 685 </div> 686 687 </div> 688 689 <div class="article"> 690 691 692 <h5 class="title"> 693 <a class="title" href="http://www.chinaphar.com/article/view/11613"> 694 PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer 695 </a> 696 697 698 </h5> 699 700 <div class="authors"> 701 Wan-mei Liu, Jia-hui Xu, Chun-yong Ding, Ao Zh
701ang </div> 702 703 <div class="galleries"> 704 </div> 705 706 </div> 707 708 <div class="article"> 709 710 711 <h5 class="title"> 712 <a class="title" href="http://www.chinaphar.com/article/view/11614"> 713 6 METTL16 S-glutathionylation-triggered RNA m A modification of IGF2BP3 inhibits CFTR expression and promotes chemoresistance in colorectal cancer 714 </a> 715 716 717 </h5> 718 719 <div class="authors"> 720 Lu Xu, Yan Ma, Wang Yao, Ya-ju Qiu, Chao Xu, Fang-yue Xu, Zhi-miao Zou, Wu-min Dai, Wan-gang Gong, De-ning Ma, Xiao-wan Chen, Wen-kai Ye, Yi-yun Huang, Hai-tao Chen, Lue Hong, Jia-ping Mo, Jian-guo Feng, En-yan Yu, Wei Chen, Yu-hua Zhang, Qing-hua Yao, Xia Li </div> 721 722 <div class="galleries"> 723 </div> 724 725 </div> 726 727 <div class="article"> 728 729 730 <h5 class="title"> 731 <a class="title" href="http://www.chinaphar.com/article/view/11615"> 732 CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53- mediated expression of SLC7A11 and GPX4 733 </a> 734 735 736 </h5> 737 738 <div class="authors"> 739 Qi Yan, Ming-ming Sun, Xin-ru Zhai, Hong-kai Chang, Xin-yue Geng, Xiao-bo Zhai, Chen-xin Yang, Yan-ping Li, Tao Wang, Jian-guo Zh
739ao, Tao He, Chang-liang Shan, Shuai Zhang </div> 740 741 <div class="galleries"> 742 </div> 743 744 </div> 745 746 <div class="article"> 747 748 749 <h5 class="title"> 750 <a class="title" href="http://www.chinaphar.com/article/view/11616"> 751 Time-resolved proteomic and phosphoproteomic analysis reveals convergent and divergent biological perturbations induced by FDA-approved CDK4/6 inhibitors in hormone receptor-positive breast cancers 752 </a> 753 754 755 </h5> 756 757 <div class="authors"> 758 Shi-yu Duan, Lin-hui Zhai, Wei Zhang, Luo-yi Chen, Rui-xi Zhao, Xun Zou, Jia-hui Ni, Xing-long Jia, Tian-yu Liu, Hang Fu, Min Huang, Min-jia Tan, Cheng-yu Chu, Yi-ting Jin </div> 759 760 <div class="galleries"> 761 </div> 762 763 </div> 764 765 <div class="article"> 766 767 768 <h5 class="title"> 769 <a class="title" href="http://www.chinaphar.com/article/view/11617"> 770 Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication 771 </a> 772 773 774 </h5> 775 776 <div class="authors"> 777 Jie-hong Chen, Hong-hui Li, Chao-xin Chen, Cai-xin Yan, Xuan-ming Liang, Cui Guo, Yu Han, Yun-hua Tang, Ying Liu, Jing Cai, Yuan Lin, Jian-kai Liang, Jun Hu, Guang-mei Yan, Jing-jie Li, Wen-bo Zhu </div> 778 779 <div class="galleries"> 780 </div> 781 782 </div> 783 784 <div class="article"> 785 786 787 <h5 class="title"> 788 <a class="title" href="http://www.chinaphar.com/article/view/11618"> 789 Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 + reactivates CD8 T cell immunity and suppresses tumor growth 790 </a> 791 792 793 </h5> 794 795 <div class="authors"> 796 Ju-fei Li, Hao Wang, Ling Kang, Cheng-cheng Xu, Yuan-chun Liu, Zi-xuan
796Li, Shao-hao Lin, Ming-zhi Wang, Xiao-min Xu, Pei-pei Wang, Wan-chao Yin, Yu-bo Zhou, Yu Zhou, Jia Li </div> 797 798 <div class="galleries"> 799 </div> 800 801 </div> 802 </div> 803 <div class="section"> 804 805 <h3 class="section-title">Correction</h3> 806 807 <div class="article"> 808 809 810 <h5 class="title"> 811 <a class="title" href="http://dx.doi.org/10.1038/s41401-026-01837-2"> 812 Correction: Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1âNRG2âHECW1 pathway 813 </a> 814 815 816 </h5> 817 818 <div class="authors"> 819 Qing Wu, Qi Su, Man Zhu, Tian-feng Yang, Wen-juan Tang, Yu Hu, Jia-yan Ren, Xiu-hong Peng, Su-yu Zhang, Yan-min Zhang </div> 820 821 <div class="galleries"> 822 </div> 823 824 </div> 825 826 <div class="article"> 827 828 829 <h5 class="title"> 830 <a class="title" href="http://dx.doi.org/10.1038/s41401-026-01798-6"> 831 Correction: Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis 832 </a> 833 834 835 </h5> 836 837 <div class="authors"> 838 Min Tian, Xi-sha Chen, Lan-ya Li, Hai-zhou Wu, Da Zeng, Xin-luan Wang, Yi Zhang, Song-shu Xiao, Yan Cheng </div> 839 840 <div class="galleries"> 841 </div> 842 843 </div> 844 </div> 845 </div> 846 847 848 <div id="most-read-articles"> 849 </div> 850 851 <div id="featured-articles"> 852 853 </div> 854 855 <div id="nih-funded"> 856 </div> 857 858 <div id="publish-ahead-of-print"> 859 <p>
859Below are the latest Acta Pharmacologica Sinica articles published online ahead of print 860 publication.</p> 861 862 <div class="clearfix"> 863 <div>Currently no content available!</div> 864 </div> 865 866 </div> 867 868 <div id="articles-on-mdlinx"> 869 <div class="clearfix"> 870 <ul> 871 </ul> 872 </div> 873 </div> 874 875 </div> 876 877 </div> 878 879 880 <style> 881 .apsOs{ 882 width: 16px; 883 float: left; 884 margin-right: 10px; 885 } 886 </style> 887
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