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655 <span class="list-item-label">PLEGRIDY Intramuscular Prefilled Syringe Administration Pack (PDF)</span> 656 <picture> 657 <source media="(max-width: 991px)"/> 658 <source media="(min-width: 992px)"/> 659 660 </picture> 661 </a> 662 </li> 663 664 <li class="list-item dropdown-item"> 665 <a class="list-item-link" aria-label="list-item-link" href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-titration-kit.pdf" rel="noopener noreferrer" target="_blank"> 666 <span class="list-item-label">PLEGRIDY Intramuscular Prefilled Syringe Titration Kit (PDF)</span> 667 <picture> 668 <source media="(max-width: 991px)"/> 669 <source media="(min-width: 992px)"/> 670 671 </picture> 672 </a> 673 </li> 674 </ul> 675 </div> 676 </div> 677 </div> 678 679 680 681 </div> 682 683 684 685 </div> 686 687 </div> 688 <div class="header-utilitynav-wrapper"> 689 <div class="container"> 690 <div class="d-flex flex-row row py-1"> 691 <div class="col-2 px-lg-0 d-inline-block d-lg-none"> 692 <button type="button" class="cmp-main-nav-btn navbar-toggler"> 693 <span class="sr-only">Toggle navigation</span> 694 <span class="icon-bar"></span> 695 <span class="icon-bar"></span> 696 <span class="icon-bar"></span> 697 </button> 698 </div> 699 <div class="col-8 col-lg-3"> 700 701 702 703 704 705 <div class="logo"> 706 707<div class="cmp-logo"> 708 <a class="cmp-logo-link" aria-label="plegridy logo" href="https://www.plegridy.com" target="_self">
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"></span> 832 <ul class="dropdown-menu active-child-link"> 833 <li class="dropdown-item active-child-innerlink"> 834 <a href="/en_us/home/about/why-plegridy.html" aria-label="Why PLEGRIDY?" class="">Why PLEGRIDY?</a> 835 </li> 836 837 <li class="dropdown-item "> 838 <a href="/en_us/home/about/efficacy.html" aria-label="Efficacy" class="">Efficacy</a> 839 </li> 840 841 <li class="dropdown-item "> 842 <a href="/en_us/home/about/safety-side-effects.html" aria-label="Safety and Side Effects " class="">Safety and Side Effects </a> 843 </li> 844 845 <li class="dropdown-item "> 846 <a href="/en_us/home/about/additional-considerations.html" aria-label="Additional Considerations" class="">Additional Considerations</a> 847 </li> 848 </ul> 849 </li> 850 851 852 853 854 855 856 <li class="nav-item dropdown "> 857 <a class="nav-link child-link" aria-label="Starting PLEGRIDY" href="/en_us/home/starting-plegridy/dosing.html"> 858 Starting PLEGRIDY 859 </a> 860 <span class="icon arrow-down-icon dropdown-toggle-icon" id="dropdownMenuLink-1" role="button" aria-haspopup="true" aria-expanded="true" aria-label="Starting PLEGRIDY"></span> 861 <ul class="dropdown-menu "> 862 <li class="dropdown-item "> 863 <a href="/en_us/home/starting-plegridy/dosing.html" aria-label="Starting PLEGRIDY" class="">Starting PLEGRIDY</a> 864 </li> 865 866 <li class="dropdown-item "> 867 <a href="/en_us/home/starting-plegridy/before-taking-plegridy.html" aria-label="Before Taking PLEGRIDY" class="">Before Taking PLEGRIDY</a> 868 </li> 869 870 <li class="dropdown-item "> 871 <a href="/en_us/home/starting-plegridy/how-to-take-plegridy.html" aria-label="How to Take PLEGRIDY" class="">How to Take PLEGRIDY</a> 872 </li> 873 874 <li class="dropdown-item "> 875 <a href="/en_us/home/starting-plegridy/faq.html" aria-label="FAQ" class="">FAQ</a> 876 </li> 877 </ul> 878 </li> 879 880 881 882 883 884 885 <li class="nav-item dropdown "> 886 <a class="nav-link child-link" aria-label="About RMS" href="/en_us/home/about-rms.html"> 887 About RMS 888 </a> 889 890 891 </li> 892 893 894 895 896 897 898 <li class="nav-item dropdown "> 899 <a class="nav-link child-link" aria-label="Cost Info & Support" href="/en_us/home/support/biogen-support-services.html"> 900 Cost Info & Support 901 </a> 902 <span class="icon arrow-down-icon dropdown-toggle-icon" id="dropdownMenuLink-3" role="button" aria-haspopup="true" aria-expanded="true" aria-label="Cost Info & Support"></span> 903 <ul class="dropdown-menu "> 904 <li class="dropdown-item "> 905 <a href="/en_us/home/support/biogen-support-services.html" aria-label="Biogen Support Services" class="">Biogen Support Services</a> 906 </li> 907 908 <li class="dropdown-item "> 909 <a href="/en_us/home/support/financial-information.html" aria-label="Financial and Insurance Support " class="">Financial and Insurance Support </a> 910 </li> 911 912 <li class="dropdown-item "> 913 <a href="/en_us/home/support/support-resources.html" aria-label="Support Resources" class="">Support Resources</a> 914 </li> 915 </ul> 916 </li> 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 1001 </ul> 1002 1003 <ul class="nav col-lg-2 main-nav-right justify-content-end"> 1004 <li class="nav-item w-lg-75"> 1005 <div class="my-account"> 1006 1007 <div class="myaccount-wrapper float-lg-right" id="9a26082a"> 1008 <div class="signed-out-container"> 1009 <a href="/en_us/home/registration.html" id="signin-link" aria-label="Sign up" class="myaccount-signinLink text-lg-center">Sign up</a> 1010 </div> 1011 <div class="signed-in-container"> 1012 <a id="myaccount-link" class="myaccount-link text-lg-center" aria-label="My Account"> 1013 My Account
1014 <span class="myaccount-link-icon arrow-down-icon"></span> 1015 </a> 1016 <ul class="myaccount-dropdown" id="myaccount-dropdown-wrapper"> 1017 <li class="myaccount-dropdown-list"> 1018 <a href="/en_us/home/edit-profile.html" aria-label="Edit Profile" class="myaccount-dropdown-link"> 1019 Edit Profile 1020 </a> 1021 </li> 1022 <li class="myaccount-dropdown-list"> 1023 <a href="#" id="logout-link" class="myaccount-dropdown-link" aria-label="Logout">Logout</a> 1024 </li> 1025 </ul> 1026 <input type="hidden" value="/bin/dxp/userprofile.logout.json" id="logoutSession"/> 1027 <input type="hidden" class="ciam-logout" value="/bin/dxp/generic.json" id="ciamlogoutSession"/> 1028 <input type="hidden" name="domain" id="portal_domain" value="www.plegridy.com"/> 1029 <input type="hidden" name="portal" value="PLEGRIDY.COM"/> 1030 <input type="hidden" name="serviceType" id="serviceTypeInp" value="neuro"/> 1031 <input type="hidden" name="siteId" id="siteId"/> 1032 <input type="hidden" name="redirectionURL" id="logoutSuccessUrl"/> 1033 </div> 1034 </div> 1035 1036 1037 1038 1039</div> 1040 1041 </li> 1042 <!--for desktop search--> 1043 <li class="nav-item cmp-search-list-item d-none d-lg-inline-block w-lg-25"> 1044 <span class="cmp-search"> 1045 <div class="search"> 1046 1047 <span tabindex="0" class="icon search-icon"></span> 1048 <div class="search-section hide-search"> 1049 1050 1051 <form class="search-section-wrapper searchInputForm" method="GET" action="/en_us/home/search.html" role="search"> 1052 <div class="dropdown"> 1053 <input aria-label="search" role="searchbox" type="text" inputmode="search" name="q" class="search-section-input" list="myDropdown" autocomplete="off"/> 1054 <datalist id="myDropdown" class="dropdown-content"></datalist> 1055 </div> 1056 <div class="hidden search-section-error"></div> 1057 <button type="submit" aria-label="search button" class="search-section-imgLink"></button> 1058 </form> 1059 <a href="#" aria-label="search closebtn" class="search-section-closebtn d-none d-lg-inline-block"></a> 1060 </div> 1061 1062 1063 1064</div> 1065 1066 </span> 1067 </li> 1068 1069 <li class="nav-item cmp-support contact-support d-inline-block d-lg-none"> 1070 <div class="d-block d-lg-none contact-support-mobile"> 1071 <a class="contact-support-link contact-support-telephone contact-support-withoutphone" aria-label="Biogen Support<span class="contact-number">800.456.2255</span>" href="tel:800.456.2255"> 1072 <span class="contact-support-imgtelephone phone-icon"></span> 1073 <span>Biogen Support<span class="contact-number">800.456.2255</span></span> 1074 </a> 1075 <a class="contact-support-link contact-support-telephone contact-support-withphone" aria-label="Biogen Support<span class="contact-number">800.456.2255</span>" href="tel:800.456.2255"> 1076 <span class="contact-support-text">Biogen Support<span class="contact-number">800.456.2255</span></span> 1077 <span class="contact-support-imgtelephone phone-icon"></span> 1078 <span class="contact-support-number">800.456.2255</span> 1079 </a> 1080 </div> 1081 </li> 1082 1083 1084 </ul> 1085 1086 1087 1088 <ul class="nav cmp-utility-nav-list d-block d-lg-none" data-listsize="11"> 1089 <li class="nav-item cmp-main-nav-utility-link"> 1090 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-prescribing-information.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1091 Prescribing Information 1092 </a> 1093 </li> 1094 1095 <li class="nav-item cmp-main-nav-utility-link"> 1096 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-medication-guide.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1097 Medication Guide 1098 </a> 1099 </li> 1100 1101 <li class="nav-item cmp-main-nav-utility-link"> 1102 <a href="/en_us/home/important-safety-information.html" class="nav-link" target="_self"> 1103 Important Safety Information 1104 </a> 1105 </li> 1106 1107 <li class="nav-item cmp-main-nav-utility-link"> 1108 <a href="https://www.plegridyhcp.com/?cid=aff-plegridy-header_forhealthcareprofessionals-plegridyhcp_hp" class="nav-link" rel="noopener noreferrer" target="_blank"> 1109 For Healthcare Professionals 1110 </a> 1111 </li> 1112 1113 <li class="nav-item cmp-main-nav-utility-link"> 1114 <a href="#" class="nav-link pointer-none" target="_self"> 1115 Instructions For Use 1116 </a> 1117 </li> 1118 1119 <li class="nav-item cmp-main-nav-utility-link"> 1120 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-pen-starter-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1121 PLEGRIDY Subcutaneous Pen Starter Pack (PDF) 1122 </a> 1123 </li> 1124 1125 <li class="nav-item cmp-main-nav-utility-link"> 1126 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-pen-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1127 PLEGRIDY Subcutaneous Pen Administration Pack (PDF) 1128 </a> 1129 </li> 1130 1131 <li class="nav-item cmp-main-nav-utility-link"> 1132 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-prefilled-syringe-starter-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1133 PLEGRIDY Subcutaneous Prefilled Syringe Starter Pack (PDF) 1134 </a> 1135 </li> 1136 1137 <li class="nav-item cmp-main-nav-utility-link"> 1138 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-prefilled-syringe-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1139 PLEGRIDY Subcutaneous Prefilled Syringe Administration Pack (PDF) 1140 </a> 1141 </li> 1142 1143 <li class="nav-item cmp-main-nav-utility-link"> 1144 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-prefilled-syringe-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1145 PLEGRIDY Intramuscular Prefilled Syringe Administration Pack (PDF) 1146 </a> 1147 </li> 1148 1149 <li class="nav-item cmp-main-nav-utility-link"> 1150 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-titration-kit.pdf" class="nav-link" rel="noopener noreferrer" target="_blank"> 1151 PLEGRIDY Intramuscular Prefilled Syringe Titration Kit (PDF) 1152 </a> 1153 </li> 1154 </ul> 1155 1156 1157 </nav> 1158 </div> 1159 1160 1161 1162 1163</div> 1164 1165 1166 1167 </div> 1168 1169 1170 1171 </div> 1172 </div> 1173 </header> 1174 <div class="subnav-horizontal-dropdown-menu"> 1175 <div class="container"> 1176 <ul class="d-none d-lg-block active-child-list"> 1177
1178 <li class="active-subnav-link"> 1179 <a href="/en_us/home/about/why-plegridy.html" class="">Why PLEGRIDY?</a> 1180 </li> 1181 1182 1183 1184 <li> 1185 <a href="/en_us/home/about/efficacy.html" class="">Efficacy</a> 1186 </li> 1187 1188 1189 1190 <li> 1191 <a href="/en_us/home/about/safety-side-effects.html" class="">Safety and Side Effects </a> 1192 </li> 1193 1194 1195 1196 <li> 1197 <a href="/en_us/home/about/additional-considerations.html" class="">Additional Considerations</a> 1198 </li> 1199 1200 </ul> 1201 </div> 1202 </div> 1203 </div> 1204 1205 1206 1207 1208 1209 1210 1211 </div> 1212<div class="responsivegrid aem-GridColumn aem-GridColumn--default--12"> 1213 1214 1215<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> 1216 1217 <div class="image-mobile-support aem-GridColumn cmp_image-mobile-support_style1 aem-GridColumn--default--12"> 1218 1219<div class="img-left-alinged cmp-image-desktop "> 1220 1221 1222 1223 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image.jpg.web.1280.1280.jpeg" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image.jpg.web.1280.1280.jpeg" class="cmp-image"> 1224 <noscript data-cmp-hook-image="noscript"> 1225 <img src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image.jpg.web.1280.1280.jpeg" alt="Woman sketching on canvas" class="cmp-image__image" data-cmp-hook-image="image"/> 1226 </noscript> 1227 </div> 1228 1229 1230 1231</div> 1232 1233<div class="cmp-image-mobile "> 1234 1235 1236 1237 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" class="cmp-image"> 1238 <noscript data-cmp-hook-image="noscript"> 1239 <picture data-cmp-hook-image="image"> 1240 <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg"/> 1241 <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg"/> 1242 <img src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" alt="Woman sketching on canvas" class="cmp-image__image"/> 1243 </picture> 1244 </noscript> 1245 </div> 1246 1247 1248</div> 1249 1250 1251</div> 1252<div class="column-control aem-GridColumn aem-GridColumn--default--12"> 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 1271 1272 1273 1274<div class="container"> 1275 <div class="row "> 1276 1277 <div class="col col-12"> 1278 <div class="column-control-column"> 1279 <div class="dxp-title section cmp--title__style1"> 1280 <h1 class="heading-h1">Why PLEGRIDY?</h1> 1281 1282 1283 1284</div> 1285 1286 1287 </div> 1288 </div> 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 </div> 1312 <!--//row --> 1313</div> 1314 1315 1316</div> 1317<div class="column-control cmp--column-control__style9 aem-GridColumn aem-GridColumn--default--12"> 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 1336 1337 1338 1339<div class="container"> 1340 <div class="row "> 1341 1342 1343 1344 1345 1346 1347 1348 <div class="col col-12 col-lg-8"> 1349 <div class="column-control-column"> 1350 <div class="subtitle section"> 1351 1352<h3 class="heading-h3">Explore if PLEGRIDY could be right for you 1353 </h3> 1354 1355 1356</div> 1357<div class="hr section"> 1358 1359 <div style=" min-height: 20px;"> 1360 </div> 1361 1362 1363 1364 1365</div> 1366<div class="column-control section"> 1367 1368 1369 1370 1371 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 <div class="row "> 1390 1391 <div class="col col-12"> 1392 <div class="column-control-column"> 1393 <div class="rich-text text section"><div class="cmp-text"> 1394 1395 1396 <p>Whether youâre considering a change in therapy or are starting treatment for the first time, weâre pleased youâve decided to learn more about PLEGRIDY.</p> 1397<p>PLEGRIDY (pronounced plegg-rih-dee) is an injectable treatment for relapsing forms of multiple sclerosis (MS) that offers low dosing frequency. <b>That means you inject PLEGRIDY once every 2 weeksâa total of 26 times a year.</b></p> 1398 1399 1400</div> 1401 1402 1403 1404</div> 1405<div class="hr section"> 1406 1407 <div style=" min-height: 20px;"> 1408 </div> 1409 1410 1411 1412 1413</div> 1414<div class="hr section"> 1415 1416 <div style=" min-height: 10px;"> 1417 </div> 1418 1419 1420 1421 1422</div> 1423<div class="subtitle section"> 1424 1425<h3 class="heading-h3">Explore more about PLEGRIDY for relapsing MS 1426 </h3> 1427 1428 1429</div> 1430<div class="hr section"> 1431 1432 <div style=" min-height: 20px;"> 1433 </div> 1434 1435 1436 1437 1438</div> 1439<div class="column-control section"> 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 1460 1461 1462 <div class="row "> 1463 1464 1465 <div class="col col-12 col-lg-6"> 1466 <div class="column-control-column"> 1467 <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy cta-tile cmp--cta-tile__style10"> 1468 1469 1470 1471 <div class="cmp-cta-tile-wrapper"> 1472 <div class="d-flex flex-wrap cmp-cta-tile vertical-alignment make-tile-clickable" data-tile-wrap="true" target="_self"> 1473 <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/en_us/home/about/efficacy.html" target="_self"></a> 1474 <div class="cmp-cta-img-wrapper"> 1475 <a href="/en_us/home/about/efficacy.html" aria-label="PLEGRIDY effectiveness" role="link" class="cmp-cta-img-link" target="_self"> 1476 1477 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" class="cmp-image"> 1478 <noscript data-cmp-hook-image="noscript"> 1479 <picture data-cmp-hook-image="image"> 1480 <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png"/> 1481 <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png"/> 1482 <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" alt="PLEGRIDY effectiveness"/> 1483 </picture> 1484 </noscript> 1485 </div> 1486 </a> 1487 </div> 1488 <div class="cmp-cta-desc-wrapper without-image"> 1489 <div class="cmp-cta-description"> 1490 <a href="/en_us/home/about/efficacy.html" class="cmp-cta-title-link" title="PLEGRIDY effectiveness" aria-hidden="false" target="_self"> 1491 PLEGRIDY effectiveness 1492 </a> 1493 <p>Understand the potential benefits.</p> 1494 1495 </div> 1496 1497 <a href="/en_us/home/about/efficacy.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/efficacy.html" class="cmp-button-link shape-fill-medium-btn" aria-label="See results" target="_self"> 1498 See results 1499 </a> 1500 1501 </div> 1502 </div> 1503 </div> 1504 1505 1506 1507 1508 1509 1510 1511</div> 1512</div> 1513</div> 1514<div class="hr section cmp--horizontal-rule__style2"> 1515 1516 <div style=" width: 100%; min-height: 30px;"> 1517 </div> 1518 1519 1520 1521 1522</div> 1523 1524 1525 </div> 1526 </div> 1527 <!--//col --> 1528 <div class="col col-12 col-lg-6"> 1529 <div class="column-control-column"> 1530 <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy_67233379 cta-tile cmp--cta-tile__style10"> 1531 1532 1533 1534 <div class="cmp-cta-tile-wrapper"> 1535 <div class="d-flex flex-wrap cmp-cta-tile vertical-alignment make-tile-clickable" data-tile-wrap="true" target="_self"> 1536 <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/en_us/home/about/safety-side-effects.html" target="_self"></a> 1537 <div class="cmp-cta-img-wrapper"> 1538 <a href="/en_us/home/about/safety-side-effects.html" aria-label="Life Preserver Safety" role="link" class="cmp-cta-img-link" target="_self"> 1539 1540 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png.web.540.960.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" class="cmp-image"> 1541 <noscript 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<a href="/en_us/home/about/safety-side-effects.html" class="cmp-cta-title-link" title="Safety and side effects" aria-hidden="false" target="_self"> 1554 Safety and side effects 1555 </a> 1556 <p>Get details about the serious and most common side effects.</p> 1557 1558 </div> 1559 1560 <a href="/en_us/home/about/safety-side-effects.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/safety-side-effects.html" class="cmp-button-link shape-fill-medium-btn" aria-label="Take a look" target="_self"> 1561 Take a look 1562 </a> 1563 1564 </div> 1565 </div> 1566 </div> 1567 1568 1569 1570 1571 1572 1573 1574</div> 1575</div> 1576</div> 1577<div class="hr section cmp--horizontal-rule__style2"> 1578 1579 <div style=" width: 100%; min-height: 30px;"> 1580 </div> 1581 1582 1583 1584 1585</div> 1586 1587 1588 </div> 1589 </div> 1590 <!--//col --> 1591 1592 1593 1594 1595 1596 1597 1598 1599 1600 1601 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 </div> 1613 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href="/en_us/home/about/additional-considerations.html" aria-label="Pregn
1663ancy" role="link" class="cmp-cta-img-link" target="_self"> 1664 1665 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" class="cmp-image"> 1666 <noscript data-cmp-hook-image="noscript"> 1667 <picture data-cmp-hook-image="image"> 1668 <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png"/> 1669 <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png"/> 1670 <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" alt="Pregnancy"/> 1671 </picture> 1672 </noscript> 1673 </div> 1674 </a> 1675 </div> 1676 <div class="cmp-cta-desc-wrapper without-image"> 1677 <div class="cmp-cta-description"> 1678 <a href="/en_us/home/about/additional-considerations.html" class="cmp-cta-title-link" title="Specific populations" aria-hidden="false" target="_self"> 1679 Specific populations 1680 </a> 1681 <p>See additional information on use during pregnancy and lactation.</p> 1682 1683 </div> 1684 1685 <a href="/en_us/home/about/additional-considerations.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/additional-considerations.html" class="cmp-button-link shape-fill-medium-btn" aria-label="Get more info " target="_self"> 1686 Get more info 1687 </a> 1688 1689 </div> 1690 </div> 1691 </div> 1692 1693 1694 1695 1696 1697 1698 1699</div> 1700</div> 1701</div> 1702 1703 1704 </div> 1705 </div> 1706 <!--//col --> 1707 <div class="col col-12 col-lg-6"> 1708 <div class="column-control-column"> 1709 1710 1711 </div> 1712 </div> 1713 <!--//col --> 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 </div> 1736 <!--//row --> 1737 1738 1739 1740</div> 1741 1742 1743 </div> 1744 </div> 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 </div> 1768 <!--//row --> 1769 1770 1771 1772</div> 1773<div class="hr section"> 1774 1775 <div style=" min-height: 2px;"> 1776 </div> 1777 1778 1779 1780 1781</div> 1782 1783 1784 </div> 1785 </div> 1786 <!--//col --> 1787 <div class="col col-12 col-lg-4"> 1788 <div class="column-control-column"> 1789 <div class="hr section cmp--horizontal-rule__style2"> 1790 1791 <div style=" width: 100%; min-height: 44px;"> 1792 </div> 1793 1794 1795 1796 1797</div> 1798<div class="subtitle section"> 1799 1800<h3 class="heading-h3">More to explore with PLEGRIDY 1801 </h3> 1802 1803 1804</div> 1805<div class="hr cmp--horizontal-rule__style1 section"> 1806 1807 <div style=" min-height: 11px;"> 1808 </div> 1809 1810 1811 1812 1813</div> 1814<div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy cta-tile cmp--cta-tile__style4"> 1815 1816 1817 1818 <div class="cmp-cta-tile-wrapper"> 1819 <div class="d-flex flex-wrap cmp-cta-tile horizontal-alignment make-tile-clickable" data-tile-wrap="true" rel="noopener noreferrer" target="_blank"> 1820 <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" rel="noopener noreferrer" target="_blank"></a> 1821 <div class="cmp-cta-img-wrapper"> 1822 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" aria-label="thought bubble icons" role="link" class="cmp-cta-img-link" rel="noopener noreferrer" target="_blank"> 1823 1824 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" 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alt="thought bubble icons"/> 1830 </picture> 1831 </noscript> 1832 </div> 1833 </a> 1834 </div> 1835 <div class="cmp-cta-desc-wrapper without-image"> 1836 <div class="cmp-cta-description"> 1837 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" class="cmp-cta-title-link" title="Want to know more?" aria-hidden="false" rel="noopener noreferrer" target="_blank"> 1838 Want to know more? 1839 </a> 1840 <p>Download a list of questions to help start a conversation with your healthcare provider about your relapsing MS treatment.<br /> 1841<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf">Download questions</a></p> 1842 1843 </div> 1844 1845 </div> 1846 </div> 1847 </div> 1848 1849 1850 1851 1852 1853 1854 1855</div> 1856</div> 1857</div> 1858<div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy_c cta-tile cmp--cta-tile__style6"> 1859 1860 1861 1862 <div class="cmp-cta-tile-wrapper"> 1863 <div class="d-flex flex-wrap cmp-cta-tile horizontal-alignment make-tile-clickable" data-tile-wrap="true" rel="noopener noreferrer" target="_blank"> 1864 <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-start-form.pdf" rel="noopener noreferrer" target="_blank"></a> 1865 <div class="cmp-cta-img-wrapper"> 1866 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-start-form.pdf" aria-label="Start form" role="link" class="cmp-cta-img-link" rel="noopener noreferrer" target="_blank"> 1867 1868 <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/start-form-icon.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/start-form-icon.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/start-form-icon.png 768w" 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1876 </div> 1877 </a> 1878 </div> 1879 <div class="cmp-cta-desc-wrapper without-image"> 1880 <div class="cmp-cta-description"> 1881 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-start-form.pdf" class="cmp-cta-title-link" title="PLEGRIDY Start Form" aria-hidden="false" rel="noopener noreferrer" target="_blank"> 1882 PLEGRIDY Start Form 1883 </a> 1884 <p>If youâre considering PLEGRIDY, get a head start on the process by taking this form to your next visit. It includes step-by-step instructions for you and your healthcare provider.<br> 1885<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-start-form.pdf" target="_blank">Download Start Form</a></p> 1886 1887 </div> 1888 1889 </div> 1890 </div> 1891 </div> 1892 1893 1894 1895 1896 1897 1898 1899</div> 1900</div> 1901</div> 1902 1903 1904 </div> 1905 </div> 1906 <!--//col --> 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 </div> 1924 <!--//row --> 1925</div> 1926 1927 1928</div> 1929<div class="column-control aem-GridColumn aem-GridColumn--default--12"> 1930 1931 1932 1933 1934 1935 1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951<div class="container"> 1952 <div class="row "> 1953 1954 <div class="col col-12"> 1955 <div class="column-control-column"> 1956 <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="column_control_10045 column-control cmp--column-control__style3"> 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 1973 1974 1975 1976 1977 1978<div class="container"> 1979 <div class="row "> 1980 1981 1982 <div class="col col-12 col-lg-6"> 1983 <div class="column-control-column"> 1984 <div class="subtitle cmp--subtitle__style6 section"> 1985 1986<h2 class="heading-h2">Stay connected 1987 </h2> 1988 1989 1990</div> 1991<div class="rich-text text section"><div class="cmp-text"> 1992 1993 1994 <p>Sign up to receive a free brochure with helpful information about relapsing MS, PLEGRIDY, and personalized support from <b>Biogen Support Services.</b></p> 1995 1996 1997</div> 1998 1999 2000 2001</div> 2002 2003 2004 </div> 2005 </div> 2006 <!--//col --> 2007 <div class="col col-12 col-lg-6"> 2008 <div class="column-control-column"> 2009 <div class="stay-connected section"> 2010 2011 2012<form action="javascript:void(0);"> 2013 <div class="form-group stay-connected-form"> 2014 <input type="email" inputmode="email" placeholder="Your Email Address" aria-label="stay connected form email" name="stay-connected-form-email" class="form-control stay-connected-form-email" data-regex-constraint-message="Email not valid" data-regex="^[^ <>\?\"\']*$" data-min-message="Password must be between 6-50 characters." maxlength="50" minlength="6"/> 2015 <button type="submit" data-refpath="/en_us/home/registration" aria-label="stay connected button" class="stay-connected-form-btn"> 2016 <span class="right-arrow-icon"> </span> 2017 </button> 2018 </div> 2019 <div class="error-msg d-none"><p>Please enter a valid email address.</p> 2020</div> 2021</form> 2022 2023 2024</div> 2025 2026 2027 </div> 2028 </div> 2029 <!--//col --> 2030 2031 2032 2033 2034 2035 2036 2037 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 </div> 2052 <!--//row --> 2053</div> 2054 2055 2056</div> 2057</div> 2058</div> 2059 2060 2061 </div> 2062 </div> 2063 2064 2065 2066 2067 2068 2069 2070 2071 2072 2073 2074 2075 2076 2077 2078 2079 2080 2081 2082 2083 2084 2085 </div> 2086 <!--//row --> 2087</div> 2088 2089 2090</div> 2091<div class="hr aem-GridColumn aem-GridColumn--default--12"> 2092 2093 <div style=" min-height: 15px;"> 2094 </div> 2095 2096 2097 2098 2099</div> 2100<div class="button cmp--button__style5 aem-GridColumn aem-GridColumn--default--12"> 2101 2102 <a aria-label="Next: Efficacy button" href="/en_us/home/about/efficacy.html" class="shape-fill-medium-btn cmp-button-link " target="_self">Next: Efficacy</a> 2103 2104 2105 2106 2107</div> 2108<div class="hr aem-GridColumn aem-GridColumn--default--12"> 2109 2110 <div style=" min-height: 15px;"> 2111 </div> 2112 2113 2114 2115 2116</div> 2117 2118 2119</div> 2120</div> 2121<div class="footer aem-GridColumn aem-GridColumn--default--12"> 2122 2123 2124 2125 2126 2127 <div> 2128 <footer class="footer footer-variation-one my-4"> 2129 2130 2131 2132 2133 <!-- /* ISI Rendering component is only rendered when showIsi property is checked as true on the current page */ --> 2134 2135 <div class="container px-lg-0 cmp-footer-isi-content-element"> 2136 2137 2138 <div class="isi-content"><h2>What is PLEGRIDY<sup>®</sup> (peginterferon beta-1a)?</h2> 2139<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p> 2140<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over
214065 years of age.</p> 2141<h2>Important Safety Information</h2> 2142<h3 class="no-margin">Who should not take PLEGRIDY?</h3> 2143<ul> 2144<li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p> 2145</li> 2146</ul> 2147<h3>What is the most important information I should know about PLEGRIDY?</h3> 2148<h3>PLEGRIDY can cause serious side effects, including:</h3> 2149<ul class="bullet"> 2150<li><p><b>Liver problems, or worsening of liver problems, including liver failure and death.</b> Symptoms may include yellowing of your skin or the white part of your eye, nausea, loss of appetite, tiredness, bleeding more easily than normal, confusion, sleepiness, dark colored urine, and pale stools. During your treatment with PLEGRIDY you will need to see your healthcare provider regularly. You will have regular blood tests to check for these possible side effects</p> 2151</li> 2152<li><p><b>Depression or suicidal thoughts.</b> Symptoms may include new or worsening depression (feeling hopeless or bad about yourself), thoughts of hurting yourself or suicide, irritability (getting upset easily), nervousness, or new or worsening anxiety</p> 2153</li> 2154</ul> 2155<p><b>Call your healthcare provider right away if you have any of the symptoms listed above.</b></p> 2156<h3>Before taking PLEGRIDY, tell your healthcare provider about all of your medical conditions, including if you:</h3> 2157<ul class="bullet"> 2158<li><p>Are being treated for a mental illness or had treatment in the past for any mental illness, including depression and suicidal behavior</p> 2159</li> 2160<li><p>Have or had liver problems, low blood cell counts, bleeding problems, heart problems, seizures (epilepsy), thyroid problems, or any kind of autoimmune disease (where the bodyâs immune system attacks the bodyâs own cells)</p> 2161</li> 2162<li><p>Have or had an allergic reaction to rubber or latex. The tip of the cap of the PLEGRIDY prefilled syringe for intramuscular use is made of natural rubber latex</p> 2163</li> 2164<li><p>Are pregnant or plan to become pregnant. It is not known if PLEGRIDY can harm your unborn baby</p> 2165</li> 2166<li><p>Are breastfeeding or plan to breastfeed. PLEGRIDY may pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take PLEGRIDY</p> 2167</li> 2168</ul> 2169<p class="parrafo_isi">Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.</p> 2170<h3>What are the possible side effects of PLEGRIDY?</h3> 2171<h3>PLEGRIDY may cause serious side effects, including:</h3> 2172<ul class="bullet"> 2173<li><p><b>serious allergic reactions.</b> Serious allergic reactions can happen if you take PLEGRIDY. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps. Get emergency help right away if you have any of these symptoms. Talk to your healthcare provider before taking another dose of PLEGRIDY</p> 2174</li> 2175<li><p><b>injection site reactions.</b> PLEGRIDY may commonly cause redness, pain, itching or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider</p> 2176</li> 2177<li><p><b>heart problems, including congestive heart failure.</b> Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY</p> 2178<ul class="sub-bullet"> 2179<li><p>Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heartbeat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy)</p> 2180</li> 2181</ul> 2182</li> 2183<li><p><b>blood problems and changes in your blood tests.</b> PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding, or anemia and can cause changes in your liver function tests. Your healthcare provider will do tests to monitor for side effects while you use PLEGRIDY</p> 2184</li> 2185<li><p><b>thrombotic microangiopathy (TMA).</b> TMA is a condition that involves injury to the smallest blood vessels in your body. TMA can also cause injury to your red blood cells (the cells that carry oxygen to your organs and tissues) and your platelets (cells that help your blood clot) and can sometimes lead to death. Your healthcare provider may tell you to stop taking PLEGRIDY if you develop TMA</p> 2186</li> 2187<li><p><b>pulmonary arterial hypertension.</b> Pulmonary arterial hypertension can occur with interferon beta products, including PLEGRIDY. Symptoms may include new or increasing fatigue or shortness of breath. Contact your healthcare provider right away if you develop these symptoms</p> 2188</li> 2189<li><p><b>autoimmune diseases.</b> Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta</p> 2190</li> 2191<li><p><b>seizures.</b> Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before</p> 2192</li> 2193</ul> 2194<h3>The most common side effects of PLEGRIDY include:</h3> 2195<ul class="bullet"> 2196<li><p><b>flu-like symptoms.</b> Many people who take PLEGRIDY have flu-like symptoms especially early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else</p> 2197<ul class="sub-bullet"> 2198<li><p>You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water</p> 2199</li> 2200</ul> 2201</li> 2202</ul> 2203<p class="parrafo_isi"><b>Flu-like symptoms or other common side effects of PLEGRIDY may include:</b> headache, muscle and joint aches, fever, chills, or tiredness.</p> 2204<p class="parrafo_isi">These are not all of the possible side effects of PLEGRIDY.</p> 2205<p class="parrafo_isi">Call your doctor for medical advice about side effects. You may report side effects to FDA at <span class="visible-inline-lg">1-800-FDA-1088</span><a href="tel:1-800-332-1088" class="visible-inline-md">1-800-FDA-1088</a>.</p> 2206<p class="parrafo_isi"><b>
2206Please see full <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-prescribing-information.pdf" target="_blank">Prescribing Information</a> and <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-medication-guide.pdf" target="_blank">Medication Guide.</a></b></p> 2207<p class="parrafo_isi">This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.</p> 2208</div> 2209 2210 2211 </div> 2212 <div class="isi-master-container"> 2213 2214 <div class="isi-rendering-footer isi-rendering"> 2215 <input type="hidden" name="defaultTrayStatus" value="preview"/> 2216<input type="hidden" name="suppressRememberStatus" value="true"/> 2217<input type="hidden" name="enableExpandButton" value="true"/> 2218<input type="hidden" name="enableCollapseButton" value="true"/> 2219 <!-- /* When in Edit mode, showing the help text */--> 2220 2221 <!-- /* When in Preview/Disabled mode, rendering the component */--> 2222 2223 2224 2225 2226 2227 <div class="cmp-isi hidden sticky-element col-12 is-collapsed"> 2228 <div class="isi-container preview-container"> 2229 <div class="d-flex flex-row isi-header"> 2230 <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div> 2231 <div class="more-text-container text-right px-0 col-3"> 2232 <span class="arrow up-arrow"></span> 2233 </div> 2234 </div> 2235 <div class="isi-content preview-text"> 2236 <div class="partial-isi"><div class="important-safety col col-xs-6 col-md-5"><h2>What is PLEGRIDY<sup>®</sup><br /> 2237(peginterferon beta-1a)?</h2> 2238<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p> 2239<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p> 2240</div> 2241<div class="indication col col-xs-6 col-md-7"><h2>Important Safety Information</h2> 2242<h3 class="no-margin">Who should not take PLEGRIDY?</h3> 2243<ul><li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p> 2244</li></ul> 2245<h3>What is the most important information...</h3> 2246</div> 2247</div> 2248 2249 </div> 2250 </div> 2251 <div class="isi-container collapse-container"> 2252 <div class="d-flex flex-row isi-header"> 2253 <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div> 2254 <div class="more-text-container text-right px-0 col-3"> 2255 <span class="arrow up-arrow"></span> 2256 </div> 2257 <div class="hide-text-container text-right px-0 col-3"> 2258 <span class="arrow down-arrow"></span> 2259 </div> 2260 </div> 2261 <div class="isi-content collapse-text"> 2262 <div class="partial-isi"><div class="important-safety col col-xs-6 col-md-5"><h2>What is PLEGRIDY<sup>®</sup><br /> 2263(peginterferon beta-1a)?</h2> 2264<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p> 2265<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p> 2266</div> 2267<div class="indication col col-xs-6 col-md-7"><h2>Important Safety Information</h2> 2268<h3 class="no-margin">Who should not take PLEGRIDY?</h3> 2269<ul><li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p> 2270</li></ul> 2271<h3>What is the most important information I should know about PLEGRIDY?<br /> 2272PLEGRIDY can cause serious side effects, including:</h3> 2273</div> 2274</div> 2275 2276 </div> 2277 </div> 2278 <div class="isi-container expand-container "> 2279 <div class="d-flex flex-row isi-header"> 2280 <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div> 2281 <div class="hide-text-container text-right px-0 col-3">
2282 <span class="arrow down-arrow"></span> 2283 </div> 2284 </div> 2285 <div class="isi-content expand-text"> 2286 <h2>What is PLEGRIDY<sup>®</sup> (peginterferon beta-1a)?</h2> 2287<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p> 2288<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p> 2289<h2>Important Safety Information</h2> 2290<h3 class="no-margin">Who should not take PLEGRIDY?</h3> 2291<ul> 2292<li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p> 2293</li> 2294</ul> 2295<h3>What is the most important information I should know about PLEGRIDY?</h3> 2296<h3>PLEGRIDY can cause serious side effects, including:</h3> 2297<ul class="bullet"> 2298<li><p><b>Liver problems, or worsening of liver problems, including liver failure and death.</b> Symptoms may include yellowing of your skin or the white part of your eye, nausea, loss of appetite, tiredness, bleeding more easily than normal, confusion, sleepiness, dark colored urine, and pale stools. During your treatment with PLEGRIDY you will need to see your healthcare provider regularly. You will have regular blood tests to check for these possible side effects</p> 2299</li> 2300<li><p><b>Depression or suicidal thoughts.</b> Symptoms may include new or worsening depression (feeling hopeless or bad about yourself), thoughts of hurting yourself or suicide, irritability (getting upset easily), nervousness, or new or worsening anxiety</p> 2301</li> 2302</ul> 2303<p><b>Call your healthcare provider right away if you have any of the symptoms listed above.</b></p> 2304<h3>Before taking PLEGRIDY, tell your healthcare provider about all of your medical conditions, including if you:</h3> 2305<ul class="bullet"> 2306<li><p>Are being treated for a mental illness or had treatment in the past for any mental illness, including depression and suicidal behavior</p> 2307</li> 2308<li><p>Have or had liver problems, low blood cell counts, bleeding problems, heart problems, seizures (epilepsy), thyroid problems, or any kind of autoimmune disease (where the bodyâs immune system attacks the bodyâs own cells)</p> 2309</li> 2310<li><p>Have or had an allergic reaction to rubber or latex. The tip of the cap of the PLEGRIDY prefilled syringe for intramuscular use is made of natural rubber latex</p> 2311</li> 2312<li><p>Are pregnant or plan to become pregnant. It is not known if PLEGRIDY can harm your unborn baby</p> 2313</li> 2314<li><p>Are breastfeeding or plan to breastfeed. PLEGRIDY may pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take PLEGRIDY</p> 2315</li> 2316</ul> 2317<p class="parrafo_isi">Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.</p> 2318<h3>What are the possible side effects of PLEGRIDY?</h3> 2319<h3>PLEGRIDY may cause serious side effects, including:</h3> 2320<ul class="bullet"> 2321<li><p><b>serious allergic reactions.</b> Serious allergic reactions can happen if you take PLEGRIDY. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps. Get emergency help right away if you have any of these symptoms. Talk to your healthcare provider before taking another dose of PLEGRIDY</p> 2322</li> 2323<li><p><b>injection site reactions.</b> PLEGRIDY may commonly cause redness, pain, itching or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider</p> 2324</li> 2325<li><p><b>heart problems, including congestive heart failure.</b> Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY</p> 2326<ul class="sub-bullet"> 2327<li><p>Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heartbeat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy)</p> 2328</li> 2329</ul> 2330</li> 2331<li><p><b>blood problems and changes in your blood tests.</b> PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding, or anemia and can cause changes in your liver function tests. Your healthcare provider will do tests to monitor for side effects while you use PLEGRIDY</p> 2332</li> 2333<li><p><b>thrombotic microangiopathy (TMA).</b> TMA is a condition that involves injury to the smallest blood vessels in your body. TMA can also cause injury to your red blood cells (the cells that carry oxygen to your organs and tissues) and your platelets (cells that help your blood clot) and can sometimes lead to death. Your healthcare provider may tell you to stop taking PLEGRIDY if you develop TMA</p> 2334</li> 2335<li><p><b>pulmonary arterial hypertension.</b> Pulmonary arterial hypertension can occur with interferon beta products, including PLEGRIDY. Symptoms may include new or increasing fatigue or shortness of breath. Contact your healthcare provider right away if you develop these symptoms</p> 2336</li> 2337<li><p><b>autoimmune diseases.</b> Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta</p> 2338</li> 2339<li><p><b>seizures.</b> Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before</p> 2340</li> 2341</ul> 2342<h3>The most common side effects of PLEGRIDY include:</h3> 2343<ul class="bullet"> 2344<li><p><b>flu-like symptoms.</b> Many people who take PLEGRIDY have flu-like symptoms especially early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else</p> 2345<ul class="sub-bullet"> 2346<li><p>You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water</p> 2347</li> 2348</ul> 2349</li> 2350</ul> 2351<p class="parrafo_isi"><b>Flu-like symptoms or other common side effects of PLEGRIDY may include:</b> headache, muscle and joint aches, fever, chills, or tiredness.</p> 2352<p class="parrafo_isi">These are not all of the possible side effects of PLEGRIDY.</p> 2353<p class="parrafo_isi">Call your doctor for medical advice about side effects. You may report side effects to FDA at <span class="visible-inline-lg">1-800-FDA-1088</span><a href="tel:1-800-332-1088" class="visible-inline-md">1-800-FDA-1088</a>.</p> 2354<p class="parrafo_isi"><b>
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