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665                        <a class="list-item-link" aria-label="list-item-link" href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-titration-kit.pdf" rel="noopener noreferrer" target="_blank">
666                             <span class="list-item-label">PLEGRIDY Intramuscular Prefilled Syringe Titration Kit (PDF)</span>
667								<picture>
668									 <source media="(max-width: 991px)"/>
669									 <source media="(min-width: 992px)"/>
670	      							 
671								</picture>	
672                        </a>
673                    </li>
674                </ul>      
675            </div>
676	   </div>
677  </div>
678
679
680    
681 </div>
682
683    
684
685						</div>
686					 
687                </div>
688                <div class="header-utilitynav-wrapper">
689                    <div class="container">
690                        <div class="d-flex flex-row row py-1">
691                                <div class="col-2 px-lg-0 d-inline-block d-lg-none">
692                                    <button type="button" class="cmp-main-nav-btn navbar-toggler">
693                                        <span class="sr-only">Toggle navigation</span>
694                                        <span class="icon-bar"></span>
695                                        <span class="icon-bar"></span>
696                                        <span class="icon-bar"></span>
697                                    </button>
698                                </div>
699                                <div class="col-8 col-lg-3">
700                                    
701    
702    
703    
704    
705        <div class="logo">
706
707<div class="cmp-logo">
708    <a class="cmp-logo-link" aria-label="plegridy logo" href="https://www.plegridy.com" target="_self">
709        <span data-alt="logo">
710			<picture>
711				<source media="(max-width: 991px)" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-new-logo.png"/>
712				<source media="(min-width: 992px)" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-new-logo.png"/>
713				<img src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-new-logo.png" class="cmp-logo-img" alt="plegridy logo"/>
714			</picture>        
715		</span>
716    </a>
717</div>
718
719
720    
721</div>
722
723    
724
725                                </div>
726                                <div class="col-lg-9 d-none d-lg-inline-block px-lg-0">
727                                    
728    
729    
730    
731    
732        <div class="support-contact">
733
734	
735		<div class="contact-support">
736			<div class="d-none d-lg-block contact-support-desktop">
737			<label class="contact-support-label">Biogen Support</label>
738			  <a aria-label="support contact number" class="contact-support-link contact-support-telephone" href="tel:800.456.2255">800.456.2255</a>
739			  
740			</div>
741		</div>
742	
743
744
745    
746
747</div>
748
749    
750
751                                </div>
752                                    <div class="col-2 px-lg-0 d-inline-block d-lg-none">
753                                    
754    
755    
756    
757    
758        <div class="sign-up-logo logo">
759
760<div class="cmp-logo">
761    
762</div>
763
764
765    
766</div>
767
768    
769
770                                </div>
771                        </div>
772                    </div>
773                </div>
774                <div class="header-mainnav-wrapper" id="header-mainnav-wrapper">
775                    <div class="container">
776                        <div class="d-flex flex-row row">
777                            
778    
779    
780    
781    
782        <div class="mainnav parbase">
783
784    
785    <div class="cmp-main-nav-container col-12 px-lg-0 sticky-nav ">
786        <input type="hidden" id="minNumbersOfSearch" value="0"/>
787        <span tabindex="0" class="close-icon d-lg-none navbar-close" style="display: none"></span>
788        <nav id="main-nav" class="cmp-main-nav d-lg-flex flex-row" role="navigation">
789            <ul class="nav main-navigation-list col-lg-10">
790                    <li class="nav-item cmp-search d-block d-lg-none">
791                        <div class="search">
792
793	<span tabindex="0" class="icon search-icon"></span>
794	<div class="search-section hide-search">
795    	
796 		
797	    <form class="search-section-wrapper searchInputForm" method="GET" action="/en_us/home/search.html" role="search">
798	        <div class="dropdown">
799	       		<input aria-label="search" role="searchbox" type="text" inputmode="search" name="q" class="search-section-input" list="myDropdown" autocomplete="off"/>
800            	<datalist id="myDropdown" class="dropdown-content"></datalist>
801            </div>
802			 <div class="hidden search-section-error"></div>
803	        <button type="submit" aria-label="search button" class="search-section-imgLink"></button>
804	    </form>
805	    <a href="#" aria-label="search closebtn" class="search-section-closebtn d-none d-lg-inline-block"></a>
806	</div>
807
808
809    
810</div>
811
812                    </li>
813                    
814                    <li class="nav-item">
815                        <div class="cmp-mini-logo">
816                        	<a aria-label="mini logo" href="https://www.plegridy.com">
817                            	<picture>
818									 <source media="(max-width: 991px)" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-logo.png"/>
819									 <source media="(min-width: 992px)" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-logo.png"/>
820                            		 <img class="mini-logo" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/global/plegridy-logo.png" alt="plegridy logo"/>
821								</picture>	
822                            </a>
823                        </div>
824                    </li>
825                    
826                    
827				<li class="nav-item dropdown active-link">
828                        <a class="nav-link child-link" aria-label="Why PLEGRIDY? " href="/en_us/home/about/why-plegridy.html">
829                            Why PLEGRIDY? 
830                        </a>
831					<span class="icon arrow-down-icon dropdown-toggle-icon" id="dropdownMenuLink-0" role="button" aria-haspopup="true" aria-expanded="true" aria-label="Why PLEGRIDY? "></span>
832					<ul class="dropdown-menu active-child-link">
833                            <li class="dropdown-item active-child-innerlink">
834                                <a href="/en_us/home/about/why-plegridy.html" aria-label="Why PLEGRIDY?" class="">Why PLEGRIDY?</a>
835                            </li>
836                        
837                            <li class="dropdown-item ">
838                                <a href="/en_us/home/about/efficacy.html" aria-label="Efficacy" class="">Efficacy</a>
839                            </li>
840                        
841                            <li class="dropdown-item ">
842                                <a href="/en_us/home/about/safety-side-effects.html" aria-label="Safety and Side Effects " class="">Safety and Side Effects </a>
843                            </li>
844                        
845                            <li class="dropdown-item ">
846                                <a href="/en_us/home/about/additional-considerations.html" aria-label="Additional Considerations" class="">Additional Considerations</a>
847                            </li>
848                        </ul>
849                    </li>
850                
851                    
852                    
853                    
854                    
855                    
856				<li class="nav-item dropdown ">
857                        <a class="nav-link child-link" aria-label="Starting PLEGRIDY" href="/en_us/home/starting-plegridy/dosing.html">
858                            Starting PLEGRIDY
859                        </a>
860					<span class="icon arrow-down-icon dropdown-toggle-icon" id="dropdownMenuLink-1" role="button" aria-haspopup="true" aria-expanded="true" aria-label="Starting PLEGRIDY"></span>
861					<ul class="dropdown-menu ">
862                            <li class="dropdown-item ">
863                                <a href="/en_us/home/starting-plegridy/dosing.html" aria-label="Starting PLEGRIDY" class="">Starting PLEGRIDY</a>
864                            </li>
865                        
866                            <li class="dropdown-item ">
867                                <a href="/en_us/home/starting-plegridy/before-taking-plegridy.html" aria-label="Before Taking PLEGRIDY" class="">Before Taking PLEGRIDY</a>
868                            </li>
869                        
870                            <li class="dropdown-item ">
871                                <a href="/en_us/home/starting-plegridy/how-to-take-plegridy.html" aria-label="How to Take PLEGRIDY" class="">How to Take PLEGRIDY</a>
872                            </li>
873                        
874                            <li class="dropdown-item ">
875                                <a href="/en_us/home/starting-plegridy/faq.html" aria-label="FAQ" class="">FAQ</a>
876                            </li>
877                        </ul>
878                    </li>
879                
880                    
881                    
882                    
883                    
884                    
885				<li class="nav-item dropdown ">
886                        <a class="nav-link child-link" aria-label="About RMS" href="/en_us/home/about-rms.html">
887                            About RMS
888                        </a>
889					
890					
891                    </li>
892                
893                    
894                    
895                    
896                    
897                    
898				<li class="nav-item dropdown ">
899                        <a class="nav-link child-link" aria-label="Cost Info &amp; Support" href="/en_us/home/support/biogen-support-services.html">
900                            Cost Info &amp; Support
901                        </a>
902					<span class="icon arrow-down-icon dropdown-toggle-icon" id="dropdownMenuLink-3" role="button" aria-haspopup="true" aria-expanded="true" aria-label="Cost Info &amp; Support"></span>
903					<ul class="dropdown-menu ">
904                            <li class="dropdown-item ">
905                                <a href="/en_us/home/support/biogen-support-services.html" aria-label="Biogen Support Services" class="">Biogen Support Services</a>
906                            </li>
907                        
908                            <li class="dropdown-item ">
909                                <a href="/en_us/home/support/financial-information.html" aria-label="Financial and Insurance Support " class="">Financial and Insurance Support </a>
910                            </li>
911                        
912                            <li class="dropdown-item ">
913                                <a href="/en_us/home/support/support-resources.html" aria-label="Support Resources" class="">Support Resources</a>
914                            </li>
915                        </ul>
916                    </li>
917                
918                    
919                    
920                    
921                    
922                    
923				
924                
925                    
926                    
927                    
928                    
929                    
930				
931                
932                    
933                    
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936                    
937				
938                
939                    
940                    
941                    
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943                    
944				
945                
946                    
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949                    
950                    
951				
952                
953                    
954                    
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956                    
957                    
958				
959                
960                    
961                    
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963                    
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965				
966                
967                    
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969                    
970                    
971                    
972				
973                
974                    
975                    
976                    
977                    
978                    
979				
980                
981                    
982                    
983                    
984                    
985                    
986				
987                
988                    
989                    
990                    
991                    
992                    
993				
994                
995                    
996                    
997                    
998                    
999                    
1000				
1001                </ul>
1002				 
1003                <ul class="nav col-lg-2 main-nav-right justify-content-end">
1004                    <li class="nav-item w-lg-75">
1005                        <div class="my-account">
1006
1007    <div class="myaccount-wrapper float-lg-right" id="9a26082a">
1008        <div class="signed-out-container">
1009            <a href="/en_us/home/registration.html" id="signin-link" aria-label="Sign up" class="myaccount-signinLink text-lg-center">Sign up</a>
1010        </div>
1011        <div class="signed-in-container">
1012            <a id="myaccount-link" class="myaccount-link text-lg-center" aria-label="My Account">
1013                My Account
1014                <span class="myaccount-link-icon arrow-down-icon"></span>
1015            </a>
1016            <ul class="myaccount-dropdown" id="myaccount-dropdown-wrapper">
1017                <li class="myaccount-dropdown-list">
1018					<a href="/en_us/home/edit-profile.html" aria-label="Edit Profile" class="myaccount-dropdown-link">
1019                        Edit Profile
1020                    </a>
1021                </li>
1022                <li class="myaccount-dropdown-list">
1023                    <a href="#" id="logout-link" class="myaccount-dropdown-link" aria-label="Logout">Logout</a>
1024                </li>
1025            </ul>
1026			<input type="hidden" value="/bin/dxp/userprofile.logout.json" id="logoutSession"/>
1027			<input type="hidden" class="ciam-logout" value="/bin/dxp/generic.json" id="ciamlogoutSession"/>
1028			<input type="hidden" name="domain" id="portal_domain" value="www.plegridy.com"/>
1029			<input type="hidden" name="portal" value="PLEGRIDY.COM"/>
1030			<input type="hidden" name="serviceType" id="serviceTypeInp" value="neuro"/>
1031			<input type="hidden" name="siteId" id="siteId"/>
1032			<input type="hidden" name="redirectionURL" id="logoutSuccessUrl"/>
1033        </div>
1034    </div>
1035
1036
1037    
1038
1039</div>
1040
1041                    </li>
1042					<!--for desktop search-->
1043                    <li class="nav-item cmp-search-list-item d-none d-lg-inline-block w-lg-25">
1044                        <span class="cmp-search">
1045                        	<div class="search">
1046
1047	<span tabindex="0" class="icon search-icon"></span>
1048	<div class="search-section hide-search">
1049    	
1050 		
1051	    <form class="search-section-wrapper searchInputForm" method="GET" action="/en_us/home/search.html" role="search">
1052	        <div class="dropdown">
1053	       		<input aria-label="search" role="searchbox" type="text" inputmode="search" name="q" class="search-section-input" list="myDropdown" autocomplete="off"/>
1054            	<datalist id="myDropdown" class="dropdown-content"></datalist>
1055            </div>
1056			 <div class="hidden search-section-error"></div>
1057	        <button type="submit" aria-label="search button" class="search-section-imgLink"></button>
1058	    </form>
1059	    <a href="#" aria-label="search closebtn" class="search-section-closebtn d-none d-lg-inline-block"></a>
1060	</div>
1061
1062
1063    
1064</div>
1065
1066                        </span>
1067                    </li>
1068                    
1069                    <li class="nav-item cmp-support contact-support d-inline-block d-lg-none">
1070                        <div class="d-block d-lg-none contact-support-mobile">
1071                            <a class="contact-support-link contact-support-telephone contact-support-withoutphone" aria-label="Biogen Support&lt;span class=&#34;contact-number&#34;>800.456.2255&lt;/span>" href="tel:800.456.2255">
1072                                <span class="contact-support-imgtelephone phone-icon"></span>
1073                                <span>Biogen Support<span class="contact-number">800.456.2255</span></span>
1074                            </a>
1075                            <a class="contact-support-link contact-support-telephone contact-support-withphone" aria-label="Biogen Support&lt;span class=&#34;contact-number&#34;>800.456.2255&lt;/span>" href="tel:800.456.2255">
1076                                <span class="contact-support-text">Biogen Support<span class="contact-number">800.456.2255</span></span>
1077                                <span class="contact-support-imgtelephone phone-icon"></span>
1078                                <span class="contact-support-number">800.456.2255</span>
1079                            </a>
1080                        </div>
1081                    </li>
1082                     
1083					
1084                </ul>
1085				
1086                
1087                
1088                <ul class="nav cmp-utility-nav-list d-block d-lg-none" data-listsize="11">
1089					<li class="nav-item cmp-main-nav-utility-link">
1090                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-prescribing-information.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1091                            Prescribing Information 
1092                        </a>
1093                    </li>
1094				
1095					<li class="nav-item cmp-main-nav-utility-link">
1096                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-medication-guide.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1097                            Medication Guide 
1098                        </a>
1099                    </li>
1100				
1101					<li class="nav-item cmp-main-nav-utility-link">
1102                        <a href="/en_us/home/important-safety-information.html" class="nav-link" target="_self">
1103                            Important Safety Information 
1104                        </a>
1105                    </li>
1106				
1107					<li class="nav-item cmp-main-nav-utility-link">
1108                        <a href="https://www.plegridyhcp.com/?cid=aff-plegridy-header_forhealthcareprofessionals-plegridyhcp_hp" class="nav-link" rel="noopener noreferrer" target="_blank">
1109                            For Healthcare Professionals 
1110                        </a>
1111                    </li>
1112				
1113					<li class="nav-item cmp-main-nav-utility-link">
1114                        <a href="#" class="nav-link pointer-none" target="_self">
1115                             Instructions For Use
1116                        </a>
1117                    </li>
1118				
1119					<li class="nav-item cmp-main-nav-utility-link">
1120                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-pen-starter-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1121                            PLEGRIDY Subcutaneous Pen Starter Pack (PDF)
1122                        </a>
1123                    </li>
1124				
1125					<li class="nav-item cmp-main-nav-utility-link">
1126                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-pen-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1127                            PLEGRIDY Subcutaneous Pen Administration Pack (PDF)
1128                        </a>
1129                    </li>
1130				
1131					<li class="nav-item cmp-main-nav-utility-link">
1132                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-prefilled-syringe-starter-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1133                            PLEGRIDY Subcutaneous Prefilled Syringe Starter Pack (PDF)
1134                        </a>
1135                    </li>
1136				
1137					<li class="nav-item cmp-main-nav-utility-link">
1138                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/IFU-plegridy-prefilled-syringe-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1139                            PLEGRIDY Subcutaneous Prefilled Syringe Administration Pack (PDF)
1140                        </a>
1141                    </li>
1142				
1143					<li class="nav-item cmp-main-nav-utility-link">
1144                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-prefilled-syringe-administration-pack.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1145                            PLEGRIDY Intramuscular Prefilled Syringe Administration Pack (PDF)
1146                        </a>
1147                    </li>
1148				
1149					<li class="nav-item cmp-main-nav-utility-link">
1150                        <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/ifu-plegridy-intramuscular-titration-kit.pdf" class="nav-link" rel="noopener noreferrer" target="_blank">
1151                            PLEGRIDY Intramuscular Prefilled Syringe Titration Kit (PDF)
1152                        </a>
1153                    </li>
1154				</ul>
1155				 
1156                
1157            </nav>
1158        </div>
1159
1160
1161    
1162
1163</div>
1164
1165    
1166
1167                        </div>
1168
1169                        
1170
1171                    </div>
1172                </div>
1173           </header>
1174			<div class="subnav-horizontal-dropdown-menu">
1175				<div class="container">
1176                	<ul class="d-none d-lg-block active-child-list">
1177                  	  	
1178                  		  	<li class="active-subnav-link">
1179                      			<a href="/en_us/home/about/why-plegridy.html" class="">Why PLEGRIDY?</a>
1180                      		</li>
1181                        
1182                	
1183                  	  	
1184                  		  	<li>
1185                      			<a href="/en_us/home/about/efficacy.html" class="">Efficacy</a>
1186                      		</li>
1187                        
1188                	
1189                  	  	
1190                  		  	<li>
1191                      			<a href="/en_us/home/about/safety-side-effects.html" class="">Safety and Side Effects </a>
1192                      		</li>
1193                        
1194                	
1195                  	  	
1196                  		  	<li>
1197                      			<a href="/en_us/home/about/additional-considerations.html" class="">Additional Considerations</a>
1198                      		</li>
1199                        
1200                	</ul>
1201				</div>
1202            </div>
1203        </div>
1204	
1205
1206
1207           	 		
1208        	
1209        
1210     
1211  </div>
1212<div class="responsivegrid aem-GridColumn aem-GridColumn--default--12">
1213
1214
1215<div class="aem-Grid aem-Grid--12 aem-Grid--default--12 ">
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1217    <div class="image-mobile-support aem-GridColumn cmp_image-mobile-support_style1 aem-GridColumn--default--12">
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1219<div class="img-left-alinged cmp-image-desktop ">
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1237         <div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" class="cmp-image">
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1239               <picture data-cmp-hook-image="image">
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1242				 <img src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/pages/effectiveness/woman-sketching-image-mob.jpg.web.540.960.jpeg" alt="Woman sketching on canvas" class="cmp-image__image"/>
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1278                <div class="column-control-column">
1279                    <div class="dxp-title section cmp--title__style1">
1280	<h1 class="heading-h1">Why PLEGRIDY?</h1>
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1348            <div class="col col-12 col-lg-8">
1349                <div class="column-control-column">
1350                    <div class="subtitle section">
1351
1352<h3 class="heading-h3">Explore if PLEGRIDY could be right for you
1353 </h3>
1354
1355    
1356</div>
1357<div class="hr section">
1358	
1359	<div style=" min-height: 20px;">
1360	</div>
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1366<div class="column-control section">
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1392                <div class="column-control-column">
1393                    <div class="rich-text text section"><div class="cmp-text">
1394	
1395	
1396	<p>Whether you’re considering a change in therapy or are starting treatment for the first time, we’re pleased you’ve decided to learn more about PLEGRIDY.</p>
1397<p>PLEGRIDY (pronounced plegg-rih-dee) is an injectable treatment for relapsing forms of multiple sclerosis (MS) that offers low dosing frequency. <b>That means you inject PLEGRIDY once every 2 weeks—a total of 26 times a year.</b></p>
1398
1399
1400</div>
1401
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1404</div>
1405<div class="hr section">
1406	
1407	<div style=" min-height: 20px;">
1408	</div>
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1414<div class="hr section">
1415	
1416	<div style=" min-height: 10px;">
1417	</div>
1418	
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1422</div>
1423<div class="subtitle section">
1424
1425<h3 class="heading-h3">Explore more about PLEGRIDY for relapsing MS
1426 </h3>
1427
1428    
1429</div>
1430<div class="hr section">
1431	
1432	<div style=" min-height: 20px;">
1433	</div>
1434	
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1439<div class="column-control section">
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1465            <div class="col col-12 col-lg-6">
1466                <div class="column-control-column">
1467                    <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy cta-tile cmp--cta-tile__style10">
1468
1469
1470
1471    <div class="cmp-cta-tile-wrapper">
1472		<div class="d-flex flex-wrap cmp-cta-tile vertical-alignment make-tile-clickable" data-tile-wrap="true" target="_self">
1473            <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/en_us/home/about/efficacy.html" target="_self"></a>
1474            <div class="cmp-cta-img-wrapper">
1475           		<a href="/en_us/home/about/efficacy.html" aria-label="PLEGRIDY effectiveness" role="link" class="cmp-cta-img-link" target="_self">
1476					
1477					<div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" class="cmp-image">
1478						<noscript data-cmp-hook-image="noscript">
1479							<picture data-cmp-hook-image="image">
1480					            <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png.web.540.960.png"/>
1481					            <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png"/>
1482					            <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-effectiveness-icon-v2.png" alt="PLEGRIDY effectiveness"/>
1483						   </picture>		
1484						</noscript>
1485					</div>
1486				</a>
1487            </div>
1488            <div class="cmp-cta-desc-wrapper without-image">
1489                <div class="cmp-cta-description">
1490					 <a href="/en_us/home/about/efficacy.html" class="cmp-cta-title-link" title="PLEGRIDY effectiveness" aria-hidden="false" target="_self">
1491                        PLEGRIDY effectiveness
1492                    </a>
1493                    	<p>Understand the potential benefits.</p>
1494
1495                </div>
1496                
1497                    <a href="/en_us/home/about/efficacy.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/efficacy.html" class="cmp-button-link shape-fill-medium-btn" aria-label="See results" target="_self">
1498                        See results
1499                    </a>
1500                
1501            </div>
1502        </div>
1503    </div>
1504
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1507
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1509
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1512</div>
1513</div>
1514<div class="hr section cmp--horizontal-rule__style2">
1515	
1516	<div style=" width: 100%; min-height: 30px;">
1517	</div>
1518	
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1522</div>
1523
1524
1525                </div>
1526            </div>
1527            <!--//col -->
1528            <div class="col col-12 col-lg-6">
1529                <div class="column-control-column">
1530                    <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy_67233379 cta-tile cmp--cta-tile__style10">
1531
1532
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1534    <div class="cmp-cta-tile-wrapper">
1535		<div class="d-flex flex-wrap cmp-cta-tile vertical-alignment make-tile-clickable" data-tile-wrap="true" target="_self">
1536            <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/en_us/home/about/safety-side-effects.html" target="_self"></a>
1537            <div class="cmp-cta-img-wrapper">
1538           		<a href="/en_us/home/about/safety-side-effects.html" aria-label="Life Preserver Safety" role="link" class="cmp-cta-img-link" target="_self">
1539					
1540					<div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png.web.540.960.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" class="cmp-image">
1541						<noscript data-cmp-hook-image="noscript">
1542							<picture data-cmp-hook-image="image">
1543					            <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png.web.540.960.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png.web.540.960.png"/>
1544					            <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png"/>
1545					            <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/plegridy-safety-icon.png" alt="Life Preserver Safety"/>
1546						   </picture>		
1547						</noscript>
1548					</div>
1549				</a>
1550            </div>
1551            <div class="cmp-cta-desc-wrapper without-image">
1552                <div class="cmp-cta-description">
1553					 <a href="/en_us/home/about/safety-side-effects.html" class="cmp-cta-title-link" title="Safety and side effects" aria-hidden="false" target="_self">
1554                        Safety and side effects
1555                    </a>
1556                    	<p>Get details about the serious and most common side effects.</p>
1557
1558                </div>
1559                
1560                    <a href="/en_us/home/about/safety-side-effects.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/safety-side-effects.html" class="cmp-button-link shape-fill-medium-btn" aria-label="Take a look" target="_self">
1561                        Take a look
1562                    </a>
1563                
1564            </div>
1565        </div>
1566    </div>
1567
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1571
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1574</div>
1575</div>
1576</div>
1577<div class="hr section cmp--horizontal-rule__style2">
1578	
1579	<div style=" width: 100%; min-height: 30px;">
1580	</div>
1581	
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1584
1585</div>
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1587
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1589            </div>
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1654                <div class="column-control-column">
1655                    <div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy_2002476589 cta-tile cmp--cta-tile__style10">
1656
1657
1658
1659    <div class="cmp-cta-tile-wrapper">
1660		<div class="d-flex flex-wrap cmp-cta-tile vertical-alignment make-tile-clickable" data-tile-wrap="true" target="_self">
1661            <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/en_us/home/about/additional-considerations.html" target="_self"></a>
1662            <div class="cmp-cta-img-wrapper">
1663           		<a href="/en_us/home/about/additional-considerations.html" aria-label="Pregn
1663ancy" role="link" class="cmp-cta-img-link" target="_self">
1664					
1665					<div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" class="cmp-image">
1666						<noscript data-cmp-hook-image="noscript">
1667							<picture data-cmp-hook-image="image">
1668					            <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png"/>
1669					            <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png"/>
1670					            <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/pregnancy-circle-icon.png" alt="Pregnancy"/>
1671						   </picture>		
1672						</noscript>
1673					</div>
1674				</a>
1675            </div>
1676            <div class="cmp-cta-desc-wrapper without-image">
1677                <div class="cmp-cta-description">
1678					 <a href="/en_us/home/about/additional-considerations.html" class="cmp-cta-title-link" title="Specific populations" aria-hidden="false" target="_self">
1679                        Specific populations
1680                    </a>
1681                    	<p>See additional information on use during pregnancy and lactation.</p>
1682
1683                </div>
1684                
1685                    <a href="/en_us/home/about/additional-considerations.html" data-desktop-url="/content/commercial-us/neurology/plegridy/pat/en_us/home/about/additional-considerations.html" class="cmp-button-link shape-fill-medium-btn" aria-label="Get more info " target="_self">
1686                        Get more info 
1687                    </a>
1688                
1689            </div>
1690        </div>
1691    </div>
1692
1693
1694
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1706            <!--//col -->
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1708                <div class="column-control-column">
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1769
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1771    
1772</div>
1773<div class="hr section">
1774	
1775	<div style=" min-height: 2px;">
1776	</div>
1777	
1778    
1779
1780
1781</div>
1782
1783
1784                </div>
1785            </div>
1786            <!--//col -->
1787            <div class="col col-12 col-lg-4">
1788                <div class="column-control-column">
1789                    <div class="hr section cmp--horizontal-rule__style2">
1790	
1791	<div style=" width: 100%; min-height: 44px;">
1792	</div>
1793	
1794    
1795
1796
1797</div>
1798<div class="subtitle section">
1799
1800<h3 class="heading-h3">More to explore with PLEGRIDY
1801 </h3>
1802
1803    
1804</div>
1805<div class="hr cmp--horizontal-rule__style1 section">
1806	
1807	<div style=" min-height: 11px;">
1808	</div>
1809	
1810    
1811
1812
1813</div>
1814<div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy cta-tile cmp--cta-tile__style4">
1815
1816
1817
1818    <div class="cmp-cta-tile-wrapper">
1819		<div class="d-flex flex-wrap cmp-cta-tile horizontal-alignment make-tile-clickable" data-tile-wrap="true" rel="noopener noreferrer" target="_blank">
1820            <a class="cmp-cta-tile-fullview-link" aria-hidden="true" tabindex='-1' href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" rel="noopener noreferrer" target="_blank"></a>
1821            <div class="cmp-cta-img-wrapper">
1822           		<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" aria-label="thought bubble icons" role="link" class="cmp-cta-img-link" rel="noopener noreferrer" target="_blank">
1823					
1824					<div data-cmp-is="image" data-cmp-lazy data-cmp-src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" data-cmp-srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png 1024w, /content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png 768w" data-cmp-widths="128,256,512,1024,1280,1440,1920,2048" data-asset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" class="cmp-image">
1825						<noscript data-cmp-hook-image="noscript">
1826							<picture data-cmp-hook-image="image">
1827					            <source media="(max-width: 991px)" data-srcset-mobile="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png"/>
1828					            <source media="(min-width: 992px)" data-srcset-desktop="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" srcset="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png"/>
1829					            <img class="cmp-cta-img cmp-image__image" src="/content/dam/commercial/multiple-sclerosis/plegridy/pat/en_us/images/icons/doctor-discussion-bubble-icon-v2.png" alt="thought bubble icons"/>
1830						   </picture>		
1831						</noscript>
1832					</div>
1833				</a>
1834            </div>
1835            <div class="cmp-cta-desc-wrapper without-image">
1836                <div class="cmp-cta-description">
1837					 <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf" class="cmp-cta-title-link" title="Want to know more?" aria-hidden="false" rel="noopener noreferrer" target="_blank">
1838                        Want to know more?
1839                    </a>
1840                    	<p>Download a list of questions to help start a conversation with your healthcare provider about your relapsing MS treatment.<br />
1841<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/DoctorDiscussionGuide_MedGuide_PI_12.17.pdf">Download questions</a></p>
1842
1843                </div>
1844                
1845            </div>
1846        </div>
1847    </div>
1848
1849
1850
1851
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1853
1854    
1855</div>
1856</div>
1857</div>
1858<div class="reference parbase section"><div class="cq-dd-paragraph"><div class="cta_tile_copy_copy_c cta-tile cmp--cta-tile__style6">
1859
1860
1861
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1863		<div class="d-flex flex-wrap cmp-cta-tile horizontal-alignment make-tile-clickable" data-tile-wrap="true" rel="noopener noreferrer" target="_blank">
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1882                        PLEGRIDY Start Form
1883                    </a>
1884                    	<p>If you’re considering PLEGRIDY, get a head start on the process by taking this form to your next visit. It includes step-by-step instructions for you and your healthcare provider.<br>
1885<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-start-form.pdf" target="_blank">Download Start Form</a></p>
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2136
2137                        
2138                            <div class="isi-content"><h2>What is PLEGRIDY<sup>®</sup> (peginterferon beta-1a)?</h2>
2139<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p>
2140<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 
214065 years of age.</p>
2141<h2>Important Safety Information</h2>
2142<h3 class="no-margin">Who should not take PLEGRIDY?</h3>
2143<ul>
2144<li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p>
2145</li>
2146</ul>
2147<h3>What is the most important information I should know about PLEGRIDY?</h3>
2148<h3>PLEGRIDY can cause serious side effects, including:</h3>
2149<ul class="bullet">
2150<li><p><b>Liver problems, or worsening of liver problems, including liver failure and death.</b> Symptoms may include yellowing of your skin or the white part of your eye, nausea, loss of appetite, tiredness, bleeding more easily than normal, confusion, sleepiness, dark colored urine, and pale stools. During your treatment with PLEGRIDY you will need to see your healthcare provider regularly. You will have regular blood tests to check for these possible side effects</p>
2151</li>
2152<li><p><b>Depression or suicidal thoughts.</b> Symptoms may include new or worsening depression (feeling hopeless or bad about yourself), thoughts of hurting yourself or suicide, irritability (getting upset easily), nervousness, or new or worsening anxiety</p>
2153</li>
2154</ul>
2155<p><b>Call your healthcare provider right away if you have any of the symptoms listed above.</b></p>
2156<h3>Before taking PLEGRIDY, tell your healthcare provider about all of your medical conditions, including if you:</h3>
2157<ul class="bullet">
2158<li><p>Are being treated for a mental illness or had treatment in the past for any mental illness, including depression and suicidal behavior</p>
2159</li>
2160<li><p>Have or had liver problems, low blood cell counts, bleeding problems, heart problems, seizures (epilepsy), thyroid problems, or any kind of autoimmune disease (where the body’s immune system attacks the body’s own cells)</p>
2161</li>
2162<li><p>Have or had an allergic reaction to rubber or latex. The tip&nbsp;of the cap of the PLEGRIDY prefilled syringe for intramuscular use is made of natural rubber latex</p>
2163</li>
2164<li><p>Are pregnant or plan to become pregnant. It is not known if PLEGRIDY can harm your unborn baby</p>
2165</li>
2166<li><p>Are breastfeeding or plan to breastfeed. PLEGRIDY may pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take PLEGRIDY</p>
2167</li>
2168</ul>
2169<p class="parrafo_isi">Tell your healthcare provider about all the medicines you take, including prescription and&nbsp;over-the-counter medicines, vitamins, and herbal supplements.</p>
2170<h3>What are the possible side effects of PLEGRIDY?</h3>
2171<h3>PLEGRIDY may cause serious side effects, including:</h3>
2172<ul class="bullet">
2173<li><p><b>serious allergic reactions.</b> Serious allergic reactions can happen if you take PLEGRIDY. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps. Get emergency help right away if you have any of these symptoms. Talk to your healthcare provider before taking another dose of PLEGRIDY</p>
2174</li>
2175<li><p><b>injection site reactions.</b> PLEGRIDY may commonly cause redness, pain, itching or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider</p>
2176</li>
2177<li><p><b>heart problems, including congestive heart failure.</b> Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY</p>
2178<ul class="sub-bullet">
2179<li><p>Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heartbeat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy)</p>
2180</li>
2181</ul>
2182</li>
2183<li><p><b>blood problems and changes in your blood tests.</b> PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding, or anemia and can cause changes in your liver function tests. Your healthcare provider will do tests to monitor for side effects while you use PLEGRIDY</p>
2184</li>
2185<li><p><b>thrombotic microangiopathy (TMA).</b> TMA is a condition that involves injury to the smallest blood vessels in your body. TMA can also cause injury to your red blood cells (the cells that carry oxygen to your organs and tissues) and your platelets (cells that help your blood clot) and can sometimes lead to death. Your healthcare provider may tell you to stop taking PLEGRIDY if you develop TMA</p>
2186</li>
2187<li><p><b>pulmonary arterial hypertension.</b> Pulmonary arterial hypertension can occur with interferon beta products, including PLEGRIDY. Symptoms may include new or increasing fatigue or shortness of breath. Contact your healthcare provider right away if you develop these symptoms</p>
2188</li>
2189<li><p><b>autoimmune diseases.</b> Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta</p>
2190</li>
2191<li><p><b>seizures.</b> Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before</p>
2192</li>
2193</ul>
2194<h3>The most common side effects of PLEGRIDY include:</h3>
2195<ul class="bullet">
2196<li><p><b>flu-like symptoms.</b> Many people who take PLEGRIDY have flu-like symptoms especially early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else</p>
2197<ul class="sub-bullet">
2198<li><p>You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water</p>
2199</li>
2200</ul>
2201</li>
2202</ul>
2203<p class="parrafo_isi"><b>Flu-like symptoms or other common side effects of PLEGRIDY may include:</b> headache, muscle and joint aches, fever, chills, or tiredness.</p>
2204<p class="parrafo_isi">These are not all of the possible side effects of PLEGRIDY.</p>
2205<p class="parrafo_isi">Call your doctor for medical advice about side effects. You may report side effects to FDA at <span class="visible-inline-lg">1-800-FDA-1088</span><a href="tel:1-800-332-1088" class="visible-inline-md">1-800-FDA-1088</a>.</p>
2206<p class="parrafo_isi"><b>
2206Please see full <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-prescribing-information.pdf" target="_blank">Prescribing Information</a> and&nbsp;<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-medication-guide.pdf" target="_blank">Medication Guide.</a></b></p>
2207<p class="parrafo_isi">This information does not take the place of talking with your healthcare provider about your&nbsp;medical condition or your treatment.</p>
2208</div>
2209                        
2210                        
2211                    </div>
2212					<div class="isi-master-container">
2213                        
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2227    <div class="cmp-isi hidden sticky-element col-12 is-collapsed">
2228        <div class="isi-container preview-container">
2229            <div class="d-flex flex-row isi-header">
2230                <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div>
2231                <div class="more-text-container text-right px-0 col-3">
2232                    <span class="arrow up-arrow"></span>
2233                </div>
2234            </div>
2235            <div class="isi-content preview-text">
2236                <div class="partial-isi"><div class="important-safety col col-xs-6 col-md-5"><h2>What is PLEGRIDY<sup>®</sup><br />
2237(peginterferon beta-1a)?</h2>
2238<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p>
2239<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p>
2240</div>
2241<div class="indication col col-xs-6 col-md-7"><h2>Important Safety Information</h2>
2242<h3 class="no-margin">Who should not take PLEGRIDY?</h3>
2243<ul><li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p>
2244</li></ul>
2245<h3>What is the most important information...</h3>
2246</div>
2247</div>
2248
2249            </div>
2250        </div>
2251        <div class="isi-container collapse-container">
2252            <div class="d-flex flex-row isi-header">
2253                <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div>
2254                <div class="more-text-container text-right px-0 col-3">
2255                    <span class="arrow up-arrow"></span>
2256                </div>
2257                <div class="hide-text-container text-right px-0 col-3">
2258                    <span class="arrow down-arrow"></span>
2259                </div>
2260            </div>
2261            <div class="isi-content collapse-text">
2262                <div class="partial-isi"><div class="important-safety col col-xs-6 col-md-5"><h2>What is PLEGRIDY<sup>®</sup><br />
2263(peginterferon beta-1a)?</h2>
2264<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p>
2265<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p>
2266</div>
2267<div class="indication col col-xs-6 col-md-7"><h2>Important Safety Information</h2>
2268<h3 class="no-margin">Who should not take PLEGRIDY?</h3>
2269<ul><li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p>
2270</li></ul>
2271<h3>What is the most important information I should know about PLEGRIDY?<br />
2272PLEGRIDY can cause serious side effects, including:</h3>
2273</div>
2274</div>
2275
2276            </div>
2277        </div>
2278        <div class="isi-container expand-container  ">
2279            <div class="d-flex flex-row isi-header">
2280                <div class="isi-container-title col-9 pl-0">Indication and Important <br class="visible-xs" />Safety Information</div>
2281                <div class="hide-text-container text-right px-0 col-3">
2282                    <span class="arrow down-arrow"></span>
2283                </div>
2284            </div>
2285            <div class="isi-content expand-text">
2286                <h2>What is PLEGRIDY<sup>®</sup> (peginterferon beta-1a)?</h2>
2287<p>PLEGRIDY is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.</p>
2288<p>It is not known if PLEGRIDY is safe and effective in people under 18 or over 65 years of age.</p>
2289<h2>Important Safety Information</h2>
2290<h3 class="no-margin">Who should not take PLEGRIDY?</h3>
2291<ul>
2292<li><p><b>Do not take PLEGRIDY if you</b> are allergic to interferon beta or peginterferon, or any of the other ingredients in PLEGRIDY</p>
2293</li>
2294</ul>
2295<h3>What is the most important information I should know about PLEGRIDY?</h3>
2296<h3>PLEGRIDY can cause serious side effects, including:</h3>
2297<ul class="bullet">
2298<li><p><b>Liver problems, or worsening of liver problems, including liver failure and death.</b> Symptoms may include yellowing of your skin or the white part of your eye, nausea, loss of appetite, tiredness, bleeding more easily than normal, confusion, sleepiness, dark colored urine, and pale stools. During your treatment with PLEGRIDY you will need to see your healthcare provider regularly. You will have regular blood tests to check for these possible side effects</p>
2299</li>
2300<li><p><b>Depression or suicidal thoughts.</b> Symptoms may include new or worsening depression (feeling hopeless or bad about yourself), thoughts of hurting yourself or suicide, irritability (getting upset easily), nervousness, or new or worsening anxiety</p>
2301</li>
2302</ul>
2303<p><b>Call your healthcare provider right away if you have any of the symptoms listed above.</b></p>
2304<h3>Before taking PLEGRIDY, tell your healthcare provider about all of your medical conditions, including if you:</h3>
2305<ul class="bullet">
2306<li><p>Are being treated for a mental illness or had treatment in the past for any mental illness, including depression and suicidal behavior</p>
2307</li>
2308<li><p>Have or had liver problems, low blood cell counts, bleeding problems, heart problems, seizures (epilepsy), thyroid problems, or any kind of autoimmune disease (where the body’s immune system attacks the body’s own cells)</p>
2309</li>
2310<li><p>Have or had an allergic reaction to rubber or latex. The tip&nbsp;of the cap of the PLEGRIDY prefilled syringe for intramuscular use is made of natural rubber latex</p>
2311</li>
2312<li><p>Are pregnant or plan to become pregnant. It is not known if PLEGRIDY can harm your unborn baby</p>
2313</li>
2314<li><p>Are breastfeeding or plan to breastfeed. PLEGRIDY may pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take PLEGRIDY</p>
2315</li>
2316</ul>
2317<p class="parrafo_isi">Tell your healthcare provider about all the medicines you take, including prescription and&nbsp;over-the-counter medicines, vitamins, and herbal supplements.</p>
2318<h3>What are the possible side effects of PLEGRIDY?</h3>
2319<h3>PLEGRIDY may cause serious side effects, including:</h3>
2320<ul class="bullet">
2321<li><p><b>serious allergic reactions.</b> Serious allergic reactions can happen if you take PLEGRIDY. Symptoms may include itching, swelling of the face, eyes, lips, tongue, or throat, trouble breathing, feeling faint, anxiousness, skin rash, hives, or skin bumps. Get emergency help right away if you have any of these symptoms. Talk to your healthcare provider before taking another dose of PLEGRIDY</p>
2322</li>
2323<li><p><b>injection site reactions.</b> PLEGRIDY may commonly cause redness, pain, itching or swelling at the place where the injection was given. Call your healthcare provider right away if an injection site becomes swollen and painful or the area looks infected. You may have a skin infection or an area of severe skin damage (necrosis) requiring treatment by a healthcare provider</p>
2324</li>
2325<li><p><b>heart problems, including congestive heart failure.</b> Call your healthcare provider right away if you have worsening symptoms of heart failure such as shortness of breath or swelling of your lower legs or feet while using PLEGRIDY</p>
2326<ul class="sub-bullet">
2327<li><p>Some people using PLEGRIDY may have other heart problems, including low blood pressure, fast or abnormal heartbeat, chest pain, heart attack, or a heart muscle problem (cardiomyopathy)</p>
2328</li>
2329</ul>
2330</li>
2331<li><p><b>blood problems and changes in your blood tests.</b> PLEGRIDY can decrease your white blood cells or platelets, which can cause an increased risk of infection, bleeding, or anemia and can cause changes in your liver function tests. Your healthcare provider will do tests to monitor for side effects while you use PLEGRIDY</p>
2332</li>
2333<li><p><b>thrombotic microangiopathy (TMA).</b> TMA is a condition that involves injury to the smallest blood vessels in your body. TMA can also cause injury to your red blood cells (the cells that carry oxygen to your organs and tissues) and your platelets (cells that help your blood clot) and can sometimes lead to death. Your healthcare provider may tell you to stop taking PLEGRIDY if you develop TMA</p>
2334</li>
2335<li><p><b>pulmonary arterial hypertension.</b> Pulmonary arterial hypertension can occur with interferon beta products, including PLEGRIDY. Symptoms may include new or increasing fatigue or shortness of breath. Contact your healthcare provider right away if you develop these symptoms</p>
2336</li>
2337<li><p><b>autoimmune diseases.</b> Problems with easy bleeding or bruising (idiopathic thrombocytopenia), thyroid gland problems (hyperthyroidism and hypothyroidism), and autoimmune hepatitis have happened in some people who use interferon beta</p>
2338</li>
2339<li><p><b>seizures.</b> Some people have had seizures while taking PLEGRIDY, including people who have never had seizures before</p>
2340</li>
2341</ul>
2342<h3>The most common side effects of PLEGRIDY include:</h3>
2343<ul class="bullet">
2344<li><p><b>flu-like symptoms.</b> Many people who take PLEGRIDY have flu-like symptoms especially early in the course of therapy. These symptoms are not really the flu. You cannot pass it on to anyone else</p>
2345<ul class="sub-bullet">
2346<li><p>You may be able to manage these flu-like symptoms by taking over-the-counter pain and fever reducers and drinking plenty of water</p>
2347</li>
2348</ul>
2349</li>
2350</ul>
2351<p class="parrafo_isi"><b>Flu-like symptoms or other common side effects of PLEGRIDY may include:</b> headache, muscle and joint aches, fever, chills, or tiredness.</p>
2352<p class="parrafo_isi">These are not all of the possible side effects of PLEGRIDY.</p>
2353<p class="parrafo_isi">Call your doctor for medical advice about side effects. You may report side effects to FDA at <span class="visible-inline-lg">1-800-FDA-1088</span><a href="tel:1-800-332-1088" class="visible-inline-md">1-800-FDA-1088</a>.</p>
2354<p class="parrafo_isi"><b>
2354Please see full <a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-prescribing-information.pdf" target="_blank">Prescribing Information</a> and&nbsp;<a href="/content/dam/commercial/plegridy/pat/en_us/pdf/plegridy-medication-guide.pdf" target="_blank">Medication Guide.</a></b></p>
2355<p class="parrafo_isi">This information does not take the place of talking with your healthcare provider about your&nbsp;medical condition or your treatment.</p>
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