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139 <div class="cc-m-spacer" style="height: 50px;"> 140 141</div> 142 143</div><div id="cc-m-16017575925" class="j-module n j-header "><h2 class="" id="cc-m-header-16017575925">H-Guard</h2></div><div id="cc-m-15642716825" class="j-module n j-text "><p> 144 Before a patient can start an extra-corporeal treatment, like dialysis, cardiopulmonary bypass, ECMO and apheresis, the extra-corporeal circuit must be primed. This involves flushing 145 the circuit with saline, or similar solutions, to remove air and any particulates, and to ensure there are no leaks. H-Guard is designed to be added to the existing priming 146 fluid and applied during the existing priming procedures. 147</p> 148 149<p> 150  151</p> 152 153<p> 154 H-Guard contains a potent down-regulator of the innate immune (complement) system, <a href="/our-science/pspcn-complement-regulator/" title="PspCN Complement Regulator">based on our PspCN technology</a>, which is 155 coated on all the blood contact surfaces during the priming procedure. This coating is designed to prevent excessive complement activation being induced by the extracorporeal 156 circuit, and thereby prevent patients suffering the serious symptoms and complications that may arise. 157</p> 158 159<p> 160  161</p> 162 163<p> 164 It is known that the immune responses induced by the extracorporeal circuit varies from patient to patient. Recent research supports the hypothesis that patients with excessive complement 165 activation have an elevated risk of cardiovascular events and other serious complications. Invizius is sponsoring a major non-interventional <a href="/our-science/clinical-trials/" title="Clinical Trials">clinical study</a> to stratify patients and identify those that will benefit from intervention with H-Guard. 166</p> 167 168<p> 169  170</p> 171 172<p> 173 The intended benefits of H-Guard for patients on dialysis: 174</p> 175 176<ul> 177 <li>Preserving Residual Kidney Function 178 </li> 179 180 <li>Preventing Acute Kidney Failure becoming Chronic 181 </li> 182 183 <li>Accelerating recovery from Delayed Graft Function in kidney transplant patients 184 </li> 185 186 <li>Reducing circuit clotting/failure and enabling heparin-free dialysis 187 </li> 188 189 <li>Reducing acute patient complications affecting Quality of Life (fatigue, itching, depression) 190 </li> 191 192 <li>Reducing cardiovascular morbidity & costs 193 </li> 194</ul></div><div id="cc-m-18726319425" class="j-module n j-text "><p> 195 H-Guard<span style="font-family: Calibri, sans-serif;">®</span> is under development and not available for clinical use. 196</p></div></div> 197 198 </div> 199 </div> 200 <!-- END _section-main.sass --> 201 202 </div> 203 204 <!-- _section-aside.sass --> 205 <div class="jtpl-section-aside"> 206 207 <aside class="jtpl-sidebar sidebar-options"><div class="jtpl-sidebar__inner alignment-options"> 208 <div data-container="sidebar"><div id="cc-matrix-4774602225"><div id="cc-m-19696773825" class="j-module n j-htmlCode "><div id="google_translate_element"> 209</div>
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